pre-miRNA Information | |
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pre-miRNA | hsa-mir-655 |
Genomic Coordinates | chr14: 101049550 - 101049646 |
Synonyms | MIRN655, hsa-mir-655, MIR655 |
Description | Homo sapiens miR-655 stem-loop |
Comment | None |
RNA Secondary Structure | |
Associated Diseases |
Mature miRNA Information | |||||||||||||||||||||||||||||||
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Mature miRNA | hsa-miR-655-5p | ||||||||||||||||||||||||||||||
Sequence | 23| AGAGGUUAUCCGUGUUAUGUUC |44 | ||||||||||||||||||||||||||||||
Evidence | Experimental | ||||||||||||||||||||||||||||||
Experiments | Illumina | ||||||||||||||||||||||||||||||
SNPs in miRNA |
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Putative Targets |
Gene Information | |||||||||||||||||||||
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Gene Symbol | PRPF4 | ||||||||||||||||||||
Synonyms | HPRP4, HPRP4P, PRP4, Prp4p, RP70, SNRNP60 | ||||||||||||||||||||
Description | pre-mRNA processing factor 4 | ||||||||||||||||||||
Transcript | NM_004697 | ||||||||||||||||||||
Expression | |||||||||||||||||||||
Putative miRNA Targets on PRPF4 | |||||||||||||||||||||
3'UTR of PRPF4 (miRNA target sites are highlighted) |
>PRPF4|NM_004697|3'UTR 1 ATGACAATGGGAAAAGGACTTGAACCTCAAGCTCTCTCTAAGGAGCTGTTTTCCTCAAACGAGAAGAATTGAAGTGTTTA 81 GTTCTATCATGTTTTCTGCCAATTACCATGCATAGACCCTCAGTAGAATTGGATTTCCATGTCAGCCCCCACTCCAGGAA 161 GGCAGCCCAATCCCTAGGTGATGGGGAACCCCTCTCACGGTTGAAAATTTATTACCTTTTTACGCCCTGCCACGAACTGT 241 GTAGACATTGTTTTTATTAATCTTTTGTTTGGCCGGGCGTGGTGGCTCACGCCTGTAATCCTAGCACTTTGGGAGGCCGA 321 GGTGGGTAGATCGCTTGAGCTCAGGAGTTCAAGACGAGCCTGGGCAACATGGCAAATGCCGTCTCTGCAAAAAAATACTA 401 AAATTAGCTGGTCGCGGTGGCTTCTGCCTGTGATTCCGGCTACTTGGGAGGCTGAGGTGGGAGGGATTGCTTAAGCCTGG 481 GAGGCAGAGGTTGCAGTGAGCCGAGATTGCGCCATTGCACTCTAGCCTGTGTGACAGAGCAAGACCCTGTCTCAAAAAAA 561 AAAAAAATTTGTTCGAATGCCTTATAGCCTTCCTCACAGCACCCAGGATTGTGACTGACTCTGCATTTTTAATTCTTGAA 641 ACTTGGCTTTCCATAACATGGTACATGCTTCAGGACTACATATGACCCAGAGAGCAAGGTGGCTGAACTATAGTCTGGAA 721 GCCCTCAGGTAAAGAGGCACATCTCACCACTCATTGGTTAAACAATGCATCATAGCGAGCACTTTTCCTTTCCCTGGAGA 801 ATGGGATGTGAAGCAGTAGACCGCAGCCACGCCGATGGTTATACAGTGAAGAAGACTTCACCTCTTCCTATTGAGTTTGC 881 TTGGAATGCTGACAGCATCAGGCAACTCTGAACTGAACATTTGCTTTGTCAGAAAATATCTTTTTTTTTACTTTGAAGTT 961 TGGCAACCTTCATGTTACCCCAAAGCAAAACCATTGTGTCAGGAGTCAAACAAATGTTTAGAAAGCAAACATGACGTCTC 1041 TATTGTACAACCTCCTTTCTCTTGGCTGTTTAAAGGATGTACTTCGTGTATTAAAGGGTACTTTATGTTGAAGTAACGAA 1121 AAAACCCTAATGGGTGTTCCTAAACCTAAACCTTTTCTTTATTCCACATTTGCTACGGTAAAATCCTGTTACAAAACTAC 1201 CCTATAAAGAATTATTTTCTATAGTTAAGCATTTTCTGAATCCTAAAAAAAAAAAAAAAAAA Target sites
Provided by authors
Predicted by miRanda
DRVs
SNPs
DRVs & SNPs
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miRNA-target interactions (Predicted by miRanda) |
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DRVs in gene 3'UTRs | |||||||||||||||||||||
SNPs in gene 3'UTRs |
Experimental Support 1 for Functional miRNA-Target Interaction | |
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miRNA:Target | ---- |
Validation Method |
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Conditions | BC-1 |
Location of target site | 3'UTR |
Tools used in this research | TargetScan , miRTarCLIP , Piranha |
Original Description (Extracted from the article) |
...
PAR-CLIP data was present in GSM796037. RNA binding protein: AGO2. Condition:4-Thiouridine
... - Gottwein E; Corcoran DL; Mukherjee N; et al., 2011, Cell host & microbe. |
Article |
- Gottwein E; Corcoran DL; Mukherjee N; et al. - Cell host & microbe, 2011
Primary effusion lymphoma (PEL) is caused by Kaposi's sarcoma-associated herpesvirus (KSHV) and frequently also harbors Epstein-Barr virus (EBV). The expression of KSHV- and EBV-encoded microRNAs (miRNAs) in PELs suggests a role for these miRNAs in latency and lymphomagenesis. Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites. In addition to a known viral analog of cellular miR-155, we show that KSHV encodes a viral miRNA that mimics cellular miR-142-3p function. In summary, this study identifies an extensive list of KSHV miRNA targets, which are likely to influence viral replication and pathogenesis.
LinkOut: [PMID: 22100165]
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CLIP-seq Support 1 for dataset GSM796037 | |
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Method / RBP | PAR-CLIP / AGO2 |
Cell line / Condition | BC-1 / 4-Thiouridine |
Location of target site | ENST00000374199.4 | 3UTR | UCAAGCUCUCUCUAAG |
Tools used in this analysis | TargetScan, miRTarCLIP, and Piranha |
Article / Accession Series | PMID: 22100165 / GSE32109 |
CLIP-seq Viewer | Link |
MiRNA-Target Expression Profile | |||||||
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MiRNA-Target Expression Profile (TCGA) | |||||||
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91 hsa-miR-655-5p Target Genes:
Functional analysis:
ID | Target | Description | Validation methods | |||||||||
Strong evidence | Less strong evidence | |||||||||||
MIRT080691 | KIAA1468 | KIAA1468 | 2 | 2 | ||||||||
MIRT095086 | SEC24A | SEC24 homolog A, COPII coat complex component | 2 | 4 | ||||||||
MIRT122450 | SMIM13 | small integral membrane protein 13 | 2 | 2 | ||||||||
MIRT214635 | SMAD5 | SMAD family member 5 | 2 | 4 | ||||||||
MIRT268267 | CCND1 | cyclin D1 | 2 | 2 | ||||||||
MIRT312418 | GRPEL2 | GrpE like 2, mitochondrial | 2 | 2 | ||||||||
MIRT329008 | DSTN | destrin, actin depolymerizing factor | 2 | 2 | ||||||||
MIRT329824 | PDCD4 | programmed cell death 4 | 2 | 4 | ||||||||
MIRT389635 | LRRC58 | leucine rich repeat containing 58 | 2 | 6 | ||||||||
MIRT443969 | FAM198B | family with sequence similarity 198 member B | 2 | 2 | ||||||||
MIRT444080 | C12orf73 | chromosome 12 open reading frame 73 | 2 | 2 | ||||||||
MIRT444886 | TMEM196 | transmembrane protein 196 | 2 | 2 | ||||||||
MIRT445506 | CRNKL1 | crooked neck pre-mRNA splicing factor 1 | 2 | 4 | ||||||||
MIRT446292 | ACSL3 | acyl-CoA synthetase long chain family member 3 | 2 | 2 | ||||||||
MIRT446462 | THAP1 | THAP domain containing 1 | 2 | 2 | ||||||||
MIRT446472 | THUMPD3 | THUMP domain containing 3 | 2 | 2 | ||||||||
MIRT447413 | MED21 | mediator complex subunit 21 | 2 | 2 | ||||||||
MIRT447491 | KIAA1715 | lunapark, ER junction formation factor | 2 | 2 | ||||||||
MIRT448965 | CDADC1 | cytidine and dCMP deaminase domain containing 1 | 2 | 2 | ||||||||
MIRT449602 | INIP | INTS3 and NABP interacting protein | 2 | 2 | ||||||||
MIRT449607 | PRPF4 | pre-mRNA processing factor 4 | 2 | 2 | ||||||||
MIRT449737 | TAB2 | TGF-beta activated kinase 1/MAP3K7 binding protein 2 | 2 | 2 | ||||||||
MIRT451668 | KRT8 | keratin 8 | 2 | 4 | ||||||||
MIRT452424 | QDPR | quinoid dihydropteridine reductase | 2 | 2 | ||||||||
MIRT455187 | AGTRAP | angiotensin II receptor associated protein | 2 | 2 | ||||||||
MIRT456059 | SLC25A28 | solute carrier family 25 member 28 | 2 | 2 | ||||||||
MIRT456488 | SERAC1 | serine active site containing 1 | 2 | 2 | ||||||||
MIRT456631 | ARMCX6 | armadillo repeat containing, X-linked 6 | 2 | 2 | ||||||||
MIRT459621 | SLC25A33 | solute carrier family 25 member 33 | 2 | 2 | ||||||||
MIRT461162 | SLC11A2 | solute carrier family 11 member 2 | 2 | 4 | ||||||||
MIRT461990 | PACSIN1 | protein kinase C and casein kinase substrate in neurons 1 | 2 | 2 | ||||||||
MIRT463149 | ZNF385A | zinc finger protein 385A | 2 | 4 | ||||||||
MIRT463465 | ZC3HAV1L | zinc finger CCCH-type containing, antiviral 1 like | 2 | 2 | ||||||||
MIRT463801 | XPOT | exportin for tRNA | 2 | 2 | ||||||||
MIRT464010 | WDR26 | WD repeat domain 26 | 2 | 2 | ||||||||
MIRT465302 | TRIB1 | tribbles pseudokinase 1 | 2 | 2 | ||||||||
MIRT468837 | RRM2 | ribonucleotide reductase regulatory subunit M2 | 2 | 2 | ||||||||
MIRT469132 | RNF126 | ring finger protein 126 | 2 | 2 | ||||||||
MIRT469244 | RHOB | ras homolog family member B | 2 | 2 | ||||||||
MIRT472414 | NCKAP1 | NCK associated protein 1 | 2 | 2 | ||||||||
MIRT472432 | NCBP2 | nuclear cap binding protein subunit 2 | 2 | 2 | ||||||||
MIRT472808 | MTMR12 | myotubularin related protein 12 | 2 | 2 | ||||||||
MIRT477893 | DVL3 | dishevelled segment polarity protein 3 | 2 | 4 | ||||||||
MIRT477963 | DPM2 | dolichyl-phosphate mannosyltransferase subunit 2, regulatory | 2 | 2 | ||||||||
MIRT479258 | CHSY1 | chondroitin sulfate synthase 1 | 2 | 2 | ||||||||
MIRT479718 | CCNF | cyclin F | 2 | 2 | ||||||||
MIRT480231 | C9orf41 | carnosine N-methyltransferase 1 | 2 | 2 | ||||||||
MIRT482600 | ABHD14B | abhydrolase domain containing 14B | 2 | 2 | ||||||||
MIRT483096 | TFPI | tissue factor pathway inhibitor | 2 | 2 | ||||||||
MIRT484644 | TBC1D5 | TBC1 domain family member 5 | 2 | 4 | ||||||||
MIRT488899 | CLDND1 | claudin domain containing 1 | 2 | 2 | ||||||||
MIRT491954 | VPS52 | VPS52, GARP complex subunit | 2 | 2 | ||||||||
MIRT496937 | LBR | lamin B receptor | 2 | 2 | ||||||||
MIRT498546 | TMEM30B | transmembrane protein 30B | 2 | 2 | ||||||||
MIRT501778 | NRBF2 | nuclear receptor binding factor 2 | 2 | 6 | ||||||||
MIRT516286 | DBT | dihydrolipoamide branched chain transacylase E2 | 2 | 2 | ||||||||
MIRT516351 | GABPB1 | GA binding protein transcription factor beta subunit 1 | 2 | 2 | ||||||||
MIRT516751 | ZNF100 | zinc finger protein 100 | 2 | 2 | ||||||||
MIRT517939 | ZNF431 | zinc finger protein 431 | 2 | 4 | ||||||||
MIRT518295 | ZNF514 | zinc finger protein 514 | 2 | 4 | ||||||||
MIRT518515 | CASP10 | caspase 10 | 2 | 2 | ||||||||
MIRT519017 | NOA1 | nitric oxide associated 1 | 2 | 2 | ||||||||
MIRT519171 | SCO1 | SCO1, cytochrome c oxidase assembly protein | 2 | 2 | ||||||||
MIRT519470 | SPTLC2 | serine palmitoyltransferase long chain base subunit 2 | 2 | 2 | ||||||||
MIRT521029 | SLC30A5 | solute carrier family 30 member 5 | 2 | 2 | ||||||||
MIRT521251 | SAMD8 | sterile alpha motif domain containing 8 | 2 | 2 | ||||||||
MIRT521682 | PRKAR2A | protein kinase cAMP-dependent type II regulatory subunit alpha | 2 | 2 | ||||||||
MIRT529386 | SKP1 | S-phase kinase associated protein 1 | 2 | 2 | ||||||||
MIRT545507 | NAP1L1 | nucleosome assembly protein 1 like 1 | 2 | 2 | ||||||||
MIRT549655 | RSL1D1 | ribosomal L1 domain containing 1 | 2 | 2 | ||||||||
MIRT551041 | CTSB | cathepsin B | 2 | 4 | ||||||||
MIRT551441 | ZNF490 | zinc finger protein 490 | 2 | 4 | ||||||||
MIRT554778 | RHEBP1 | RHEB pseudogene 1 | 2 | 4 | ||||||||
MIRT565793 | SEC14L5 | SEC14 like lipid binding 5 | 2 | 2 | ||||||||
MIRT566727 | MSL2 | MSL complex subunit 2 | 2 | 2 | ||||||||
MIRT574668 | HNRNPDL | heterogeneous nuclear ribonucleoprotein D like | 2 | 2 | ||||||||
MIRT610128 | DENND5B | DENN domain containing 5B | 2 | 2 | ||||||||
MIRT624919 | FBXW2 | F-box and WD repeat domain containing 2 | 2 | 2 | ||||||||
MIRT641830 | TRIM71 | tripartite motif containing 71 | 2 | 2 | ||||||||
MIRT662165 | IFNAR2 | interferon alpha and beta receptor subunit 2 | 2 | 2 | ||||||||
MIRT667150 | NRXN3 | neurexin 3 | 2 | 2 | ||||||||
MIRT689085 | ADNP2 | ADNP homeobox 2 | 2 | 2 | ||||||||
MIRT696322 | DCAF15 | DDB1 and CUL4 associated factor 15 | 2 | 2 | ||||||||
MIRT699062 | SNX4 | sorting nexin 4 | 2 | 2 | ||||||||
MIRT703229 | GOLGA1 | golgin A1 | 2 | 2 | ||||||||
MIRT705743 | AMD1 | adenosylmethionine decarboxylase 1 | 2 | 2 | ||||||||
MIRT706087 | HNRNPU | heterogeneous nuclear ribonucleoprotein U | 2 | 2 | ||||||||
MIRT709288 | MAPK8IP2 | mitogen-activated protein kinase 8 interacting protein 2 | 2 | 2 | ||||||||
MIRT711457 | RNF145 | ring finger protein 145 | 2 | 2 | ||||||||
MIRT714708 | PPP3CC | protein phosphatase 3 catalytic subunit gamma | 2 | 2 | ||||||||
MIRT719871 | CYP4F11 | cytochrome P450 family 4 subfamily F member 11 | 2 | 2 |
miRNA-Drug Associations | ||||||||||||||||||
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miRNA-Drug Resistance Associations | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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