miRTarBase - #MIRT449987


—
pre-miRNA Information
pre-miRNA hsa-mir-4524b   
Genomic Coordinates chr17: 69099542 - 69099656
Description Homo sapiens miR-4524b stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-4524b-3p
Sequence 66| GAGACAGGUUCAUGCUGCUA |85
Evidence Experimental
Experiments SOLiD
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1263495678 1 dbSNP
rs1350790266 9 dbSNP
rs1322445998 14 dbSNP
Putative Targets

Gene Information
Gene Symbol AEN   
Synonyms ISG20L1, pp12744
Description apoptosis enhancing nuclease
Transcript NM_022767   
Expression
Putative miRNA Targets on AEN
3'UTR of AEN
(miRNA target sites are highlighted)		 
>AEN|NM_022767|3'UTR
   1 GAAGGGGGCGGGGCTCCCTGGCTGGGCTTCCGGTGTGGCCGGTAGGAAGTGGGGGCCAGGAGAGCAGCGGGCACTCCTTC
  81 CTGGGCAGGGTGGGGCAGGATGCAGTGAGCCAGCCCCAGGGCCAGAGGAGTAGGGGTCATCTGTTACCTTGACACCCTCT
 161 GCACACAGCATAGCCCTCTCTCTCTCCAGGGCTGTTGGTTCTTTCTCCTGACTCCTGTGGTTTTGCTAATGGCACTTTAC
 241 AGACTCCATGGAGATGTCAGGTGGACCATCTTCTAGGGCCCAGCAGGAGTAGGGAATGTGCCAACAGACTGCCCAGGTTG
 321 CCGTGGCCTTCCCCACCCCCCAGATCTCCTGAGTCATCATGCTGTGCTAATGAAAGGGATCATATCATCCTCTCTGGGGA
 401 TGGTGGGTGGGGGTGTCAATATCCTGGAGCTCCCTTACCCCAACTCAATGACTTGGGGGTAAAGTTCTCTTCCTTTTGTT
 481 GCCTACCTCTTCCTCCACTCATTTGGGTTCAGAATAAACATGCCCTGAAGTTAAAGAGGAGTTAAGTCCTAAAGGAGGCA
 561 TTTCTTCCCCACCTCCCTGACCTGGAACTCTGGCTACAGCCATTGTAGGAACTCCGTGCCTGGCCTGTCAGCTCCCTGCT
 641 AGGCTACAGTGGAATAGCAGAGCCCACAGGCTTCTCGTGGGGAGTTGGCTCCTTAACATTTCTTGGCAACAGAAAGCCCC
 721 AGGCACAGCTCAGGGAGGAGGGAAGGCAGGTAAGCTTTGGACGAGAACTGGCATATTTATTTTGACCCAAATCAGGGATT
 801 TCCCCAGTCCACCCAGTACTGGGCTCTTAAGCAAAAGTCTGAGAAACAAGACAGTGGTTTGAATTCTGGGGCCTTTGTGT
 881 AGGATTGTGCCTGACCTTTATTTATTTATTAACAGCAGGGCCACTCGTCTAGGGCAGTGGAGTCTGCGTGTCTCCTGGGG
 961 CTGGGGCAGGGCATTGGCAGTTACGCAGTGGCCCTGAACCTGGTCTGGTGCCCCCGAACCTGGTCTGATGCCCCCTCAGC
1041 TCTTTGACAATCACTGTGGCTGTTGGGTTTTCTCCTATTTCTAAAAATGTTCTCTTCTTTCCTAAGTGACAGTTTTGAAG
1121 TATTGGATAACCAAGAGCTCAGGTCACACAGACCTTGGAGCCCCATCTTTGCTTGCAGCTTAGCTTTGAGATACTAAGCA
1201 AGCGAGGGACTTCACTCTTGAGGCTGTTTTTTCCTCATCTGTAAAGTGGGGATAGTGGTACGGCCTACCTCATAGGGTTG
1281 TAATGAGCACTAAATGTGAAGTGCTTGGCACAGTGCCTGGCACATGGTGAGCCACAGCTACTGTGAGTTTCTGTTTATCC
1361 CCCTTTTTTTTTTTTAAGCCCATTGTTTATTCTTTGAGAATTTGTTGTAACTTCTTCAGGATAACACCTGAGTCCACAGG
1441 CTGAGCAGCTGTGGCCCAGACAGAACTGCTCCGGCTTGGCTGTTCCAGCAGGTGGGGCGCTGGCCTCGGTGAGGGCACAG
1521 CAGCAAGGTTCACGGATATCCGTGTGTCTTGTCTGTGGCCACCAGGCACAGGTTTGGCTTCCGGTCAGTGTCCCGACACT
1601 GTGCGGGAGGTGACAACAGAGCAAAGCAGCGCAGGGGTCAGGGAGGTACAGACACTGCTGAAATCACACTACCCCACCCT
1681 CAGCTGAAGCCCCACGTTCCACAAACTTGGGGTCATAGATTGTCCAGTCACTGGCTCCCTCCCTGTCAGCACAGCACAGA
1761 GGAAGGGGCTAACTGAATCTTTTACCACTTCTGGCCTGGCTCCAGAACTTTGTTCTAGATTCCTTAAAAGTCGGTAGCTG
1841 ATGTCAAACTCAATTGAGCAGTAGCTTTGATCCCTTGGTCTGGGGGTCGAAGGAAGATGGTGCTGTTATCAGCGGGGAAA
1921 TGTACTATTTAAGATCAGCTTTGTTGTAAAACCATTTGTTCTAGAATAAAACTCAATTGGAAACGTGAAAAAAAAAAAAA
2001 AAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' auCGUC----GUACUUGGA-CAGAg 5'
            ||||    | ||||||| |||| 
Target 5' acGCAGTGGCCCTGAACCTGGTCTg 3'
 983 - 1007 136.00 -16.30
2 
miRNA  3' aucGUCGUACUUGGACAGAg 5'
             |||||| : ||| ||| 
Target 5' acaCAGCATAGCCCTCTCTc 3'
 163 - 182 133.00 -15.90
3 
miRNA  3' aucGUCGUACUUGGACAGAg 5'
             | |::||  |:||||| 
Target 5' tatCCGTGTG-TCTTGTCTg 3'
 1537 - 1555 132.00 -11.30
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30126563 11 COSMIC
COSN30090970 12 COSMIC
COSN30116965 23 COSMIC
COSN30117478 25 COSMIC
COSN6643388 32 COSMIC
COSN28774667 42 COSMIC
COSN16671588 73 COSMIC
COSM6025642 86 COSMIC
COSM7341076 91 COSMIC
COSN31592366 136 COSMIC
COSN17037619 221 COSMIC
COSN31779080 605 COSMIC
COSN25823432 755 COSMIC
COSN31589348 766 COSMIC
COSM1629734 829 COSMIC
COSN5402550 937 COSMIC
COSN13646004 948 COSMIC
COSN28824577 966 COSMIC
COSN23094722 1365 COSMIC
COSN27230749 1376 COSMIC
COSN27598454 1376 COSMIC
COSN5757504 1383 COSMIC
COSN32062482 1430 COSMIC
COSN7253147 1534 COSMIC
COSN8481362 1631 COSMIC
COSN23076557 1835 COSMIC
COSN20093032 1950 COSMIC
COSN21524693 1985 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1461234699 3 dbSNP
rs1356819960 4 dbSNP
rs764732027 4 dbSNP
rs751853313 6 dbSNP
rs745506587 7 dbSNP
rs1438625146 8 dbSNP
rs757651205 10 dbSNP
rs781200131 11 dbSNP
rs746120783 12 dbSNP
rs1224238948 14 dbSNP
rs1286163611 17 dbSNP
rs1326796922 18 dbSNP
rs1207726033 20 dbSNP
rs1253166128 22 dbSNP
rs756213497 23 dbSNP
rs780258779 24 dbSNP
rs147335655 26 dbSNP
rs186259223 29 dbSNP
rs17777460 32 dbSNP
rs1159649907 33 dbSNP
rs1414728114 34 dbSNP
rs1455925731 38 dbSNP
rs1158716070 40 dbSNP
rs773216515 41 dbSNP
rs370022294 42 dbSNP
rs1046587515 46 dbSNP
rs1407268262 48 dbSNP
rs1444336611 52 dbSNP
rs771813576 54 dbSNP
rs373412213 56 dbSNP
rs386786162 56 dbSNP
rs770791689 59 dbSNP
rs1442908227 64 dbSNP
rs988323816 65 dbSNP
rs140899692 69 dbSNP
rs759169829 70 dbSNP
rs775345426 71 dbSNP
rs899080269 71 dbSNP
rs1245552534 72 dbSNP
rs1336559426 75 dbSNP
rs1207668713 76 dbSNP
rs1288612841 77 dbSNP
rs1437894165 78 dbSNP
rs1199254862 84 dbSNP
rs996072467 94 dbSNP
rs1254516054 100 dbSNP
rs1471835297 103 dbSNP
rs949514466 108 dbSNP
rs1456503476 111 dbSNP
rs1045245593 112 dbSNP
rs1195666282 113 dbSNP
rs1473933548 114 dbSNP
rs1161662249 115 dbSNP
rs1390122399 118 dbSNP
rs757164209 120 dbSNP
rs1410535432 122 dbSNP
rs1309809270 124 dbSNP
rs1368576163 129 dbSNP
rs1409110944 130 dbSNP
rs114926971 131 dbSNP
rs561628527 132 dbSNP
rs3826038 133 dbSNP
rs752107672 136 dbSNP
rs1339488344 137 dbSNP
rs1020788016 138 dbSNP
rs1277427892 139 dbSNP
rs565627249 140 dbSNP
rs1000355738 143 dbSNP
rs1033216186 144 dbSNP
rs1426066961 150 dbSNP
rs764988881 158 dbSNP
rs958927218 160 dbSNP
rs1464208618 162 dbSNP
rs769592866 166 dbSNP
rs1222998872 168 dbSNP
rs1330805473 176 dbSNP
rs916222551 176 dbSNP
rs1406862889 177 dbSNP
rs898133781 178 dbSNP
rs970820738 179 dbSNP
rs1277645306 181 dbSNP
rs1241110420 183 dbSNP
rs981846077 192 dbSNP
rs3743474 208 dbSNP
rs752664845 214 dbSNP
rs1402703111 230 dbSNP
rs1037478779 233 dbSNP
rs920456347 241 dbSNP
rs551263710 247 dbSNP
rs931871010 256 dbSNP
rs1305309203 260 dbSNP
rs1406281711 266 dbSNP
rs1384729169 282 dbSNP
rs1157284088 288 dbSNP
rs1280423395 296 dbSNP
rs1470006525 297 dbSNP
rs1319561011 310 dbSNP
rs1050322284 315 dbSNP
rs1198867176 322 dbSNP
rs1008063022 323 dbSNP
rs890420227 324 dbSNP
rs1200442683 328 dbSNP
rs1018154909 333 dbSNP
rs964148397 334 dbSNP
rs1206819215 338 dbSNP
rs1351381729 340 dbSNP
rs1001333505 341 dbSNP
rs1032440074 343 dbSNP
rs1345169330 343 dbSNP
rs956885158 344 dbSNP
rs1201672385 350 dbSNP
rs988103147 353 dbSNP
rs748849975 357 dbSNP
rs918165251 358 dbSNP
rs1009319096 360 dbSNP
rs970985667 381 dbSNP
rs1254069661 384 dbSNP
rs1402941754 385 dbSNP
rs1441716134 390 dbSNP
rs1041753690 397 dbSNP
rs1176371586 409 dbSNP
rs67426590 414 dbSNP
rs1476979578 416 dbSNP
rs1170301387 421 dbSNP
rs1430210892 425 dbSNP
rs1475247084 430 dbSNP
rs942233016 433 dbSNP
rs773826202 439 dbSNP
rs1033167130 440 dbSNP
rs1242411819 442 dbSNP
rs1201715170 444 dbSNP
rs1324999776 470 dbSNP
rs757563706 474 dbSNP
rs1401725036 478 dbSNP
rs919696665 483 dbSNP
rs1268769550 484 dbSNP
rs1433383096 485 dbSNP
rs1366400629 486 dbSNP
rs929590764 490 dbSNP
rs1013153895 492 dbSNP
rs1300466123 496 dbSNP
rs1408378963 504 dbSNP
rs75834418 508 dbSNP
rs891041947 511 dbSNP
rs866736825 522 dbSNP
rs1169901795 523 dbSNP
rs3743473 524 dbSNP
rs568067246 526 dbSNP
rs1181609676 533 dbSNP
rs1462652630 535 dbSNP
rs1237539197 541 dbSNP
rs1203273380 543 dbSNP
rs1274613044 548 dbSNP
rs1331313609 548 dbSNP
rs1214806577 549 dbSNP
rs1343232797 556 dbSNP
rs1314868352 559 dbSNP
rs1244404977 560 dbSNP
rs1385682689 563 dbSNP
rs1303468696 566 dbSNP
rs376449113 569 dbSNP
rs73465625 576 dbSNP
rs1331069560 583 dbSNP
rs1344265425 586 dbSNP
rs956824597 591 dbSNP
rs973139087 594 dbSNP
rs1288053283 595 dbSNP
rs562842750 597 dbSNP
rs189668489 606 dbSNP
rs1268388112 616 dbSNP
rs539945987 617 dbSNP
rs1196846031 624 dbSNP
rs1377098495 630 dbSNP
rs1234115412 632 dbSNP
rs765489658 634 dbSNP
rs1490100190 635 dbSNP
rs944678024 636 dbSNP
rs1161023350 640 dbSNP
rs1359150932 646 dbSNP
rs1042090480 647 dbSNP
rs558036327 655 dbSNP
rs1304072404 656 dbSNP
rs1314001710 658 dbSNP
rs1223728609 661 dbSNP
rs576590228 676 dbSNP
rs1281415207 677 dbSNP
rs1410655829 677 dbSNP
rs1388110412 678 dbSNP
rs1345171500 683 dbSNP
rs926911379 686 dbSNP
rs1426276611 689 dbSNP
rs1350264246 691 dbSNP
rs1398946177 699 dbSNP
rs371132509 699 dbSNP
rs562368176 706 dbSNP
rs760337273 718 dbSNP
rs973601949 719 dbSNP
rs919668407 732 dbSNP
rs1013099973 738 dbSNP
rs1024510818 740 dbSNP
rs536868202 745 dbSNP
rs1266410109 746 dbSNP
rs1205066267 760 dbSNP
rs16942129 763 dbSNP
rs559327050 764 dbSNP
rs1270073133 769 dbSNP
rs943697737 773 dbSNP
rs532858265 774 dbSNP
rs997110106 776 dbSNP
rs750867305 781 dbSNP
rs1475794979 783 dbSNP
rs1170618670 788 dbSNP
rs1388367920 789 dbSNP
rs1001104287 792 dbSNP
rs764097458 795 dbSNP
rs1429104287 804 dbSNP
rs1313397302 805 dbSNP
rs756371212 807 dbSNP
rs1404105008 811 dbSNP
rs1394005071 814 dbSNP
rs114077513 815 dbSNP
rs749270685 818 dbSNP
rs1230137643 820 dbSNP
rs961705482 823 dbSNP
rs973086750 835 dbSNP
rs78102484 836 dbSNP
rs751595016 839 dbSNP
rs372130562 846 dbSNP
rs757177000 848 dbSNP
rs1484459931 851 dbSNP
rs1199042576 853 dbSNP
rs1219090226 862 dbSNP
rs1255877478 867 dbSNP
rs1447839537 868 dbSNP
rs986364275 871 dbSNP
rs1186353877 872 dbSNP
rs377352582 873 dbSNP
rs1250407276 875 dbSNP
rs1246327283 878 dbSNP
rs944609675 881 dbSNP
rs1448882178 882 dbSNP
rs1261409032 883 dbSNP
rs1235675604 884 dbSNP
rs370309303 885 dbSNP
rs1174193809 886 dbSNP
rs1215666384 888 dbSNP
rs1379259632 890 dbSNP
rs1464379919 891 dbSNP
rs1025031598 893 dbSNP
rs1290724450 894 dbSNP
rs148957684 896 dbSNP
rs1385367853 897 dbSNP
rs781136373 901 dbSNP
rs1212545363 902 dbSNP
rs1436898871 906 dbSNP
rs1318050512 907 dbSNP
rs1363831734 908 dbSNP
rs548811085 909 dbSNP
rs1302611709 914 dbSNP
rs561166443 918 dbSNP
rs1231669849 921 dbSNP
rs770826299 923 dbSNP
rs1451830669 925 dbSNP
rs776384576 927 dbSNP
rs973972688 928 dbSNP
rs1246354119 932 dbSNP
rs935991969 937 dbSNP
rs1026513794 938 dbSNP
rs745707462 948 dbSNP
rs894556965 949 dbSNP
rs1167922768 954 dbSNP
rs1427063293 956 dbSNP
rs948822780 963 dbSNP
rs1189765527 964 dbSNP
rs1239283163 970 dbSNP
rs1046301528 974 dbSNP
rs1461306536 975 dbSNP
rs1241328615 983 dbSNP
rs11559060 985 dbSNP
rs534630196 986 dbSNP
rs1250920953 987 dbSNP
rs1202709991 988 dbSNP
rs1343958954 992 dbSNP
rs1028018954 996 dbSNP
rs183264317 998 dbSNP
rs1380559598 1003 dbSNP
rs566082438 1005 dbSNP
rs1396070928 1008 dbSNP
rs1395178144 1009 dbSNP
rs539510987 1009 dbSNP
rs1296038121 1014 dbSNP
rs73465626 1016 dbSNP
rs576511005 1017 dbSNP
rs1169675431 1031 dbSNP
rs1054007897 1032 dbSNP
rs115947402 1035 dbSNP
rs985926279 1036 dbSNP
rs1046433131 1037 dbSNP
rs1194291839 1040 dbSNP
rs1183005479 1045 dbSNP
rs1275060211 1049 dbSNP
rs11852656 1054 dbSNP
rs556026974 1061 dbSNP
rs143562521 1062 dbSNP
rs1019165981 1066 dbSNP
rs1164507453 1067 dbSNP
rs768295246 1077 dbSNP
rs574364213 1078 dbSNP
rs1172227439 1085 dbSNP
rs924532853 1093 dbSNP
rs935938044 1094 dbSNP
rs990147341 1109 dbSNP
rs1440806251 1113 dbSNP
rs1350767418 1115 dbSNP
rs543101779 1124 dbSNP
rs915938347 1130 dbSNP
rs948784507 1132 dbSNP
rs1045832817 1134 dbSNP
rs1381245621 1138 dbSNP
rs1389040657 1139 dbSNP
rs532149008 1144 dbSNP
rs928755719 1149 dbSNP
rs940211330 1150 dbSNP
rs142747428 1155 dbSNP
rs1019371096 1164 dbSNP
rs115789711 1165 dbSNP
rs1473678672 1169 dbSNP
rs1252763742 1181 dbSNP
rs577574131 1186 dbSNP
rs1048696182 1199 dbSNP
rs1489770658 1203 dbSNP
rs1269212481 1204 dbSNP
rs888796097 1205 dbSNP
rs1349927206 1208 dbSNP
rs1256377673 1214 dbSNP
rs1258396468 1215 dbSNP
rs1317421237 1215 dbSNP
rs1229654342 1220 dbSNP
rs2278598 1224 dbSNP
rs936350955 1227 dbSNP
rs1402721979 1233 dbSNP
rs146546255 1236 dbSNP
rs1326014728 1238 dbSNP
rs989381446 1239 dbSNP
rs371680691 1248 dbSNP
rs1157632254 1255 dbSNP
rs966240018 1256 dbSNP
rs945176364 1259 dbSNP
rs1264292340 1261 dbSNP
rs747654696 1262 dbSNP
rs1031548511 1263 dbSNP
rs1195460915 1269 dbSNP
rs568875863 1286 dbSNP
rs1259511431 1293 dbSNP
rs957256953 1299 dbSNP
rs1055517997 1302 dbSNP
rs1262040356 1307 dbSNP
rs1221289861 1311 dbSNP
rs1420982281 1317 dbSNP
rs1276943655 1320 dbSNP
rs899141699 1325 dbSNP
rs1326235162 1326 dbSNP
rs115459440 1330 dbSNP
rs1437912126 1341 dbSNP
rs1047969707 1343 dbSNP
rs886730660 1345 dbSNP
rs1360834811 1351 dbSNP
rs1427475329 1353 dbSNP
rs1173396995 1355 dbSNP
rs1009061404 1360 dbSNP
rs1491407302 1363 dbSNP
rs1241952204 1364 dbSNP
rs1443664173 1364 dbSNP
rs576578123 1364 dbSNP
rs778133763 1364 dbSNP
rs965481625 1364 dbSNP
rs560770899 1365 dbSNP
rs915889364 1367 dbSNP
rs1339074825 1372 dbSNP
rs1028501078 1375 dbSNP
rs957691310 1382 dbSNP
rs1366627856 1383 dbSNP
rs771359728 1390 dbSNP
rs913819790 1394 dbSNP
rs1360975427 1402 dbSNP
rs966634662 1408 dbSNP
rs528336609 1410 dbSNP
rs1368467041 1421 dbSNP
rs928727568 1422 dbSNP
rs981897903 1425 dbSNP
rs1361517032 1426 dbSNP
rs780464770 1429 dbSNP
rs940137002 1437 dbSNP
rs1280741868 1447 dbSNP
rs1473454446 1450 dbSNP
rs1037141023 1451 dbSNP
rs1310987112 1459 dbSNP
rs1435783135 1462 dbSNP
rs937860083 1471 dbSNP
rs1055187260 1472 dbSNP
rs777169791 1474 dbSNP
rs920677991 1475 dbSNP
rs546883482 1479 dbSNP
rs1191949432 1486 dbSNP
rs1227122159 1489 dbSNP
rs1381413437 1493 dbSNP
rs1284925081 1497 dbSNP
rs1047793717 1499 dbSNP
rs1049986450 1500 dbSNP
rs1310111202 1508 dbSNP
rs770132836 1508 dbSNP
rs1162526737 1509 dbSNP
rs775778085 1510 dbSNP
rs1413877550 1513 dbSNP
rs141259959 1515 dbSNP
rs1471338930 1516 dbSNP
rs764340767 1519 dbSNP
rs529769772 1525 dbSNP
rs1483554848 1533 dbSNP
rs374237404 1534 dbSNP
rs1220000880 1535 dbSNP
rs1172982348 1538 dbSNP
rs999034691 1541 dbSNP
rs1361089008 1542 dbSNP
rs1421351583 1543 dbSNP
rs144859537 1545 dbSNP
rs1296057798 1549 dbSNP
rs754064749 1554 dbSNP
rs1437402314 1555 dbSNP
rs1031497449 1560 dbSNP
rs1365639635 1562 dbSNP
rs957206790 1564 dbSNP
rs1291633208 1566 dbSNP
rs1438478667 1569 dbSNP
rs570147012 1572 dbSNP
rs1158336311 1582 dbSNP
rs761931693 1583 dbSNP
rs116836487 1584 dbSNP
rs1479945588 1585 dbSNP
rs778916238 1592 dbSNP
rs981461616 1595 dbSNP
rs928648687 1596 dbSNP
rs1020608690 1599 dbSNP
rs1247758785 1604 dbSNP
rs961470090 1606 dbSNP
rs1208653260 1617 dbSNP
rs1463551954 1618 dbSNP
rs1270156188 1620 dbSNP
rs1229236952 1622 dbSNP
rs555967320 1631 dbSNP
rs1311867217 1632 dbSNP
rs1298888183 1643 dbSNP
rs35553918 1648 dbSNP
rs879363807 1648 dbSNP
rs1047276 1649 dbSNP
rs1047278 1650 dbSNP
rs927883786 1654 dbSNP
rs1248063218 1668 dbSNP
rs1468948158 1673 dbSNP
rs1357023459 1674 dbSNP
rs558866435 1675 dbSNP
rs1177830497 1691 dbSNP
rs959202713 1693 dbSNP
rs1426328020 1696 dbSNP
rs111477109 1697 dbSNP
rs553631284 1707 dbSNP
rs1192456148 1708 dbSNP
rs911473196 1714 dbSNP
rs1482987147 1716 dbSNP
rs1254420223 1719 dbSNP
rs867941901 1723 dbSNP
rs868253143 1725 dbSNP
rs1312544713 1731 dbSNP
rs570761016 1732 dbSNP
rs1156644405 1733 dbSNP
rs578220419 1733 dbSNP
rs1298272838 1736 dbSNP
rs1406910766 1737 dbSNP
rs1399440548 1745 dbSNP
rs1304160809 1746 dbSNP
rs1047741929 1757 dbSNP
rs1360103013 1763 dbSNP
rs376688586 1766 dbSNP
rs1428353131 1768 dbSNP
rs1189783833 1780 dbSNP
rs556710629 1780 dbSNP
rs375441387 1799 dbSNP
rs542330482 1808 dbSNP
rs760862885 1812 dbSNP
rs1183815819 1816 dbSNP
rs1483725207 1817 dbSNP
rs138770021 1820 dbSNP
rs1040613779 1822 dbSNP
rs1344084437 1826 dbSNP
rs1011407085 1833 dbSNP
rs1243992961 1835 dbSNP
rs1379767102 1839 dbSNP
rs769623690 1842 dbSNP
rs1023259856 1844 dbSNP
rs528275379 1850 dbSNP
rs1396217212 1851 dbSNP
rs78334104 1854 dbSNP
rs753620614 1855 dbSNP
rs932168741 1859 dbSNP
rs754618288 1863 dbSNP
rs1372815657 1865 dbSNP
rs1169771438 1881 dbSNP
rs1457904490 1884 dbSNP
rs1366764577 1886 dbSNP
rs1035664653 1887 dbSNP
rs116004933 1890 dbSNP
rs972753946 1897 dbSNP
rs8031562 1902 dbSNP
rs1483880996 1903 dbSNP
rs551727540 1910 dbSNP
rs952834666 1914 dbSNP
rs561261389 1915 dbSNP
rs1432439092 1916 dbSNP
rs1266671401 1925 dbSNP
rs1244813216 1926 dbSNP
rs1212532188 1928 dbSNP
rs1238207589 1929 dbSNP
rs1459049348 1932 dbSNP
rs1176751088 1933 dbSNP
rs911404152 1935 dbSNP
rs1286013665 1938 dbSNP
rs1229915577 1940 dbSNP
rs201586443 1942 dbSNP
rs1330019686 1944 dbSNP
rs371284839 1950 dbSNP
rs187647206 1955 dbSNP
rs1034939983 1978 dbSNP
rs922940352 1985 dbSNP
rs76070174 1986 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions BC-1
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM796037. RNA binding protein: AGO2. Condition:4-Thiouridine ...

- Gottwein E; Corcoran DL; Mukherjee N; et al., 2011, Cell host & microbe.

Article - Gottwein E; Corcoran DL; Mukherjee N; et al.
- Cell host & microbe, 2011
Primary effusion lymphoma (PEL) is caused by Kaposi's sarcoma-associated herpesvirus (KSHV) and frequently also harbors Epstein-Barr virus (EBV). The expression of KSHV- and EBV-encoded microRNAs (miRNAs) in PELs suggests a role for these miRNAs in latency and lymphomagenesis. Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites. In addition to a known viral analog of cellular miR-155, we show that KSHV encodes a viral miRNA that mimics cellular miR-142-3p function. In summary, this study identifies an extensive list of KSHV miRNA targets, which are likely to influence viral replication and pathogenesis.
LinkOut: [PMID: 22100165]
CLIP-seq Support 1 for dataset GSM796037
Method / RBP PAR-CLIP / AGO2
Cell line / Condition BC-1 / 4-Thiouridine
Location of target site ENST00000332810.3 | 3UTR | UCAAGCUAUUCCCCU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 22100165 / GSE32109
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
175 hsa-miR-4524b-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT064889 ZBTB18 zinc finger and BTB domain containing 18 2 2
MIRT075345 SF3B3 splicing factor 3b subunit 3 2 2
MIRT094174 PCGF3 polycomb group ring finger 3 2 6
MIRT100109 ABT1 activator of basal transcription 1 2 8
MIRT102242 HBP1 HMG-box transcription factor 1 2 2
MIRT124918 HCCS holocytochrome c synthase 2 2
MIRT140195 CHAC1 ChaC glutathione specific gamma-glutamylcyclotransferase 1 2 2
MIRT193891 HACD3 3-hydroxyacyl-CoA dehydratase 3 2 2
MIRT265634 LDHA lactate dehydrogenase A 2 2
MIRT303878 VAMP8 vesicle associated membrane protein 8 2 2
MIRT409756 CRTAP cartilage associated protein 2 4
MIRT441503 SPG20 spartin 2 6
MIRT446882 ZNF554 zinc finger protein 554 2 2
MIRT447093 COPRS coordinator of PRMT5 and differentiation stimulator 2 2
MIRT449987 AEN apoptosis enhancing nuclease 2 2
MIRT452116 IFITM1 interferon induced transmembrane protein 1 2 2
MIRT452654 ZNF33A zinc finger protein 33A 2 2
MIRT453886 IFRD1 interferon related developmental regulator 1 2 12
MIRT454143 FOXRED2 FAD dependent oxidoreductase domain containing 2 2 2
MIRT454501 SLC29A1 solute carrier family 29 member 1 (Augustine blood group) 2 2
MIRT456633 ARMCX6 armadillo repeat containing, X-linked 6 2 2
MIRT457021 ACADSB acyl-CoA dehydrogenase, short/branched chain 2 2
MIRT457055 NEGR1 neuronal growth regulator 1 2 2
MIRT457335 REG4 regenerating family member 4 2 2
MIRT457421 CASC5 kinetochore scaffold 1 2 2
MIRT457940 LCE1A late cornified envelope 1A 2 2
MIRT458486 RMI1 RecQ mediated genome instability 1 2 10
MIRT458662 PAGR1 PAXIP1 associated glutamate rich protein 1 2 12
MIRT459784 IDH3A isocitrate dehydrogenase 3 (NAD(+)) alpha 2 2
MIRT459864 SVOP SV2 related protein 2 2
MIRT460575 FEM1A fem-1 homolog A 2 2
MIRT460987 STK17B serine/threonine kinase 17b 2 2
MIRT462315 TMEM109 transmembrane protein 109 2 2
MIRT464407 URM1 ubiquitin related modifier 1 2 2
MIRT465148 TSC22D2 TSC22 domain family member 2 2 2
MIRT466312 TIMM22 translocase of inner mitochondrial membrane 22 2 2
MIRT466718 SYNJ2BP synaptojanin 2 binding protein 2 2
MIRT468258 SFXN4 sideroflexin 4 2 2
MIRT469140 RNF126 ring finger protein 126 2 2
MIRT471783 NUP153 nucleoporin 153 2 2
MIRT472506 NACC2 NACC family member 2 2 2
MIRT474588 KLF6 Kruppel like factor 6 2 2
MIRT475049 JOSD1 Josephin domain containing 1 2 2
MIRT476900 FBXO21 F-box protein 21 2 2
MIRT476972 FAM83G family with sequence similarity 83 member G 2 4
MIRT477433 EMP1 epithelial membrane protein 1 2 2
MIRT480334 C5orf51 chromosome 5 open reading frame 51 2 10
MIRT481179 AVL9 AVL9 cell migration associated 2 6
MIRT481693 AR androgen receptor 2 2
MIRT483280 HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 2 4
MIRT485775 B4GALT5 beta-1,4-galactosyltransferase 5 2 2
MIRT487424 CACNB1 calcium voltage-gated channel auxiliary subunit beta 1 2 2
MIRT488002 RXRB retinoid X receptor beta 2 2
MIRT488259 DNLZ DNL-type zinc finger 2 4
MIRT490360 DPYSL5 dihydropyrimidinase like 5 2 2
MIRT491593 USB1 U6 snRNA biogenesis phosphodiesterase 1 2 2
MIRT495269 IGF2BP1 insulin like growth factor 2 mRNA binding protein 1 2 4
MIRT495619 ZNF736 zinc finger protein 736 2 2
MIRT496167 ELP3 elongator acetyltransferase complex subunit 3 2 2
MIRT496250 GJB2 gap junction protein beta 2 2 2
MIRT496915 RTKN rhotekin 2 2
MIRT498713 PGAM5 PGAM family member 5, mitochondrial serine/threonine protein phosphatase 2 10
MIRT501106 SLC5A6 solute carrier family 5 member 6 2 4
MIRT501831 NCOA3 nuclear receptor coactivator 3 2 2
MIRT507142 GIGYF1 GRB10 interacting GYF protein 1 2 2
MIRT510991 PER1 period circadian clock 1 2 4
MIRT512283 ARHGDIA Rho GDP dissociation inhibitor alpha 2 6
MIRT513152 CSDC2 cold shock domain containing C2 2 2
MIRT513327 KCNMB1 potassium calcium-activated channel subfamily M regulatory beta subunit 1 2 6
MIRT515090 FAM120AOS family with sequence similarity 120A opposite strand 2 2
MIRT516113 OARD1 O-acyl-ADP-ribose deacylase 1 2 8
MIRT516657 PIGP phosphatidylinositol glycan anchor biosynthesis class P 2 2
MIRT516892 PLEKHS1 pleckstrin homology domain containing S1 2 2
MIRT517966 ZMIZ2 zinc finger MIZ-type containing 2 2 4
MIRT519492 PNPLA3 patatin like phospholipase domain containing 3 2 2
MIRT519799 ZNF226 zinc finger protein 226 2 2
MIRT524309 CTC1 CST telomere replication complex component 1 2 8
MIRT524425 CNKSR3 CNKSR family member 3 2 2
MIRT525927 KIAA0391 KIAA0391 2 2
MIRT528022 ACOT9 acyl-CoA thioesterase 9 2 2
MIRT528227 METTL8 methyltransferase like 8 2 2
MIRT528686 CEP57L1 centrosomal protein 57 like 1 2 2
MIRT528774 CD1D CD1d molecule 2 2
MIRT529935 P2RX7 purinergic receptor P2X 7 2 2
MIRT530642 PPIC peptidylprolyl isomerase C 2 4
MIRT530683 CHRNB1 cholinergic receptor nicotinic beta 1 subunit 2 4
MIRT531922 SLC4A1 solute carrier family 4 member 1 (Diego blood group) 2 2
MIRT532181 SEC14L5 SEC14 like lipid binding 5 2 4
MIRT534996 PRR11 proline rich 11 2 6
MIRT535452 PDCL phosducin like 2 4
MIRT544682 AP1S1 adaptor related protein complex 1 sigma 1 subunit 2 2
MIRT553757 TARBP2 TARBP2, RISC loading complex RNA binding subunit 2 4
MIRT560724 ZNF749 zinc finger protein 749 2 2
MIRT561518 SPTY2D1 SPT2 chromatin protein domain containing 1 2 2
MIRT561578 SLC30A1 solute carrier family 30 member 1 2 2
MIRT562483 CHORDC1 cysteine and histidine rich domain containing 1 2 2
MIRT565039 VAV2 vav guanine nucleotide exchange factor 2 2 2
MIRT565348 TMED4 transmembrane p24 trafficking protein 4 2 2
MIRT567104 KANSL1 KAT8 regulatory NSL complex subunit 1 2 2
MIRT568879 LY6H lymphocyte antigen 6 family member H 2 2
MIRT569141 NAP1L4 nucleosome assembly protein 1 like 4 2 2
MIRT569199 LRRC3C leucine rich repeat containing 3C 2 2
MIRT573559 TMEM120B transmembrane protein 120B 2 2
MIRT575931 Mrrf mitochondrial ribosome recycling factor 2 6
MIRT607035 MRRF mitochondrial ribosome recycling factor 2 9
MIRT607194 SPRY4 sprouty RTK signaling antagonist 4 2 2
MIRT609682 TMEM213 transmembrane protein 213 2 2
MIRT611227 ZNF274 zinc finger protein 274 2 2
MIRT611370 PLXDC1 plexin domain containing 1 2 4
MIRT611640 SCRG1 stimulator of chondrogenesis 1 2 2
MIRT613011 GABRB1 gamma-aminobutyric acid type A receptor beta1 subunit 2 2
MIRT613532 GTSE1 G2 and S-phase expressed 1 2 2
MIRT614459 REL REL proto-oncogene, NF-kB subunit 2 2
MIRT616492 CD300E CD300e molecule 2 2
MIRT617288 GTF2H3 general transcription factor IIH subunit 3 2 2
MIRT618356 CDKL1 cyclin dependent kinase like 1 2 2
MIRT619529 ZNF74 zinc finger protein 74 2 2
MIRT619990 ZSCAN22 zinc finger and SCAN domain containing 22 2 2
MIRT621286 ATP5E ATP synthase, H+ transporting, mitochondrial F1 complex, epsilon subunit 2 2
MIRT621482 GPKOW G-patch domain and KOW motifs 2 2
MIRT625456 RANGAP1 Ran GTPase activating protein 1 2 2
MIRT626757 NDUFA9 NADH:ubiquinone oxidoreductase subunit A9 2 2
MIRT629138 CTCFL CCCTC-binding factor like 2 2
MIRT630092 DCAF10 DDB1 and CUL4 associated factor 10 2 2
MIRT633501 RNF14 ring finger protein 14 2 2
MIRT633604 APCDD1 APC down-regulated 1 2 2
MIRT633772 F2 coagulation factor II, thrombin 2 2
MIRT635605 ADAT1 adenosine deaminase, tRNA specific 1 2 2
MIRT637422 EPB41L3 erythrocyte membrane protein band 4.1 like 3 2 2
MIRT637822 PLA2G7 phospholipase A2 group VII 2 2
MIRT637978 RRP36 ribosomal RNA processing 36 2 2
MIRT638385 RABL3 RAB, member of RAS oncogene family like 3 2 2
MIRT638547 KIAA1549 KIAA1549 2 2
MIRT642019 NCKIPSD NCK interacting protein with SH3 domain 2 2
MIRT643342 MICA MHC class I polypeptide-related sequence A 2 2
MIRT644281 LRRC57 leucine rich repeat containing 57 2 2
MIRT646818 COX19 COX19, cytochrome c oxidase assembly factor 2 2
MIRT646839 TLDC1 TBC/LysM-associated domain containing 1 2 2
MIRT646976 CYP2W1 cytochrome P450 family 2 subfamily W member 1 2 2
MIRT647735 CXCR2 C-X-C motif chemokine receptor 2 2 2
MIRT648598 ZYG11B zyg-11 family member B, cell cycle regulator 2 2
MIRT649843 LIPG lipase G, endothelial type 2 2
MIRT650031 VHL von Hippel-Lindau tumor suppressor 2 2
MIRT652082 TSPAN14 tetraspanin 14 2 2
MIRT652103 TRUB2 TruB pseudouridine synthase family member 2 2 2
MIRT652902 SYNPO2L synaptopodin 2 like 2 2
MIRT653549 SLC38A7 solute carrier family 38 member 7 2 2
MIRT653981 SEMA6B semaphorin 6B 2 2
MIRT654287 RCAN1 regulator of calcineurin 1 2 2
MIRT658372 FAM63B MINDY lysine 48 deubiquitinase 2 2 2
MIRT660321 BDP1 B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB 2 2
MIRT663063 LRIF1 ligand dependent nuclear receptor interacting factor 1 2 2
MIRT663269 ATP1A2 ATPase Na+/K+ transporting subunit alpha 2 2 2
MIRT664076 ZNF417 zinc finger protein 417 2 2
MIRT664193 MYOZ2 myozenin 2 2 2
MIRT664512 POLR3K RNA polymerase III subunit K 2 2
MIRT667025 PDF peptide deformylase, mitochondrial 2 2
MIRT669621 ACSL6 acyl-CoA synthetase long chain family member 6 2 2
MIRT670530 MLLT6 MLLT6, PHD finger containing 2 2
MIRT673050 SGPL1 sphingosine-1-phosphate lyase 1 2 2
MIRT683339 ZNF581 zinc finger protein 581 2 2
MIRT689264 WDR83OS WD repeat domain 83 opposite strand 2 2
MIRT690902 TOP2A DNA topoisomerase II alpha 2 2
MIRT699196 SLX4IP SLX4 interacting protein 2 2
MIRT702223 LONRF3 LON peptidase N-terminal domain and ring finger 3 2 2
MIRT707053 TRPV2 transient receptor potential cation channel subfamily V member 2 2 2
MIRT707080 MED29 mediator complex subunit 29 2 2
MIRT712347 NLN neurolysin 2 2
MIRT714715 KIT KIT proto-oncogene receptor tyrosine kinase 2 2
MIRT715963 CES4A carboxylesterase 4A 2 2
MIRT718224 DEFB105B defensin beta 105B 2 2
MIRT718244 DEFB105A defensin beta 105A 2 2
MIRT721960 GCK glucokinase 2 2
MIRT723098 SERINC3 serine incorporator 3 2 2
MIRT725207 PTPRT protein tyrosine phosphatase, receptor type T 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-4524b Tripterygium wilfordii Hook F resistant tissue
hsa-miR-4524b-3p Tamoxifen 2733525 NSC180973 approved sensitive cell line (LCC2)

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