miRTarBase - #MIRT449991


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pre-miRNA Information
pre-miRNA hsa-mir-6787   
Genomic Coordinates chr17: 82236668 - 82236728
Description Homo sapiens miR-6787 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-6787-5p
Sequence 6| UGGCGGGGGUAGAGCUGGCUGC |27
Evidence Experimental
Experiments Meta-analysis
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs778888046 4 dbSNP
rs772018061 5 dbSNP
rs760886644 6 dbSNP
rs776925052 7 dbSNP
rs760060985 8 dbSNP
rs1432528063 9 dbSNP
rs778772390 10 dbSNP
rs924024166 11 dbSNP
rs201523090 13 dbSNP
rs1451075810 17 dbSNP
rs1378844609 18 dbSNP
Putative Targets

Gene Information
Gene Symbol PSMG1   
Synonyms C21LRP, DSCR2, LRPC21, PAC-1, PAC1
Description proteasome assembly chaperone 1
Transcript NM_003720   
Other Transcripts NM_203433   
Expression
Putative miRNA Targets on PSMG1
3'UTR of PSMG1
(miRNA target sites are highlighted)		 
>PSMG1|NM_003720|3'UTR
   1 TCTTAAACATTGTTTTGTAGTGTATATTACTTGTCCATTCCTTTAAGGGGAGCAGCCTGCACTCTTTTGTAGATTACTTT
  81 TGGGGGATATATTTTGAGAATGATGAAACGGAATAAAATTGTAAAAAATTAATTGTAGTTTTAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' cgucggucgagauggGGGCGgu 5'
                         ||:||  
Target 5' ctttaaggggagcagCCTGCac 3'
 41 - 62 84.00 -10.80
2 
miRNA  3' cgucggucgagauggGGGCGGu 5'
                         |::|:| 
Target 5' ttgtagtgtatattaCTTGTCc 3'
 15 - 36 72.00 -8.40
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30119608 2 COSMIC
COSN30489061 40 COSMIC
COSN30122178 62 COSMIC
COSN29262348 155 COSMIC
COSN29539542 267 COSMIC
COSN24266754 514 COSMIC
COSN5986835 569 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs773712591 2 dbSNP
rs866651421 4 dbSNP
rs1250476856 8 dbSNP
rs372999986 9 dbSNP
rs950798371 9 dbSNP
rs1359983153 10 dbSNP
rs372725988 11 dbSNP
rs369293244 12 dbSNP
rs376387960 16 dbSNP
rs770325169 17 dbSNP
rs1307490425 22 dbSNP
rs199591509 23 dbSNP
rs1434126534 25 dbSNP
rs769239406 26 dbSNP
rs1295304132 27 dbSNP
rs540997233 30 dbSNP
rs778498196 32 dbSNP
rs1162203263 33 dbSNP
rs1422109765 36 dbSNP
rs1364735728 37 dbSNP
rs756889109 43 dbSNP
rs749006588 48 dbSNP
rs1036674886 57 dbSNP
rs1018204894 61 dbSNP
rs1235756128 67 dbSNP
rs528472631 76 dbSNP
rs1177371444 81 dbSNP
rs759117074 85 dbSNP
rs559456127 86 dbSNP
rs561959331 91 dbSNP
rs908514658 94 dbSNP
rs1455861778 96 dbSNP
rs1393599390 103 dbSNP
rs546179747 104 dbSNP
rs1457990835 107 dbSNP
rs957883740 109 dbSNP
rs577367826 110 dbSNP
rs112902650 114 dbSNP
rs1431074368 119 dbSNP
rs1252192897 120 dbSNP
rs543848602 123 dbSNP
rs9305670 129 dbSNP
rs1256549788 130 dbSNP
rs902190787 140 dbSNP
rs1454280941 142 dbSNP
rs1024691474 159 dbSNP
rs9305669 187 dbSNP
rs1388621834 198 dbSNP
rs9982122 206 dbSNP
rs999495988 216 dbSNP
rs967675735 221 dbSNP
rs1240559503 226 dbSNP
rs1330390364 236 dbSNP
rs1055397974 247 dbSNP
rs1377988080 262 dbSNP
rs1487198411 265 dbSNP
rs1021673683 267 dbSNP
rs757284873 267 dbSNP
rs1331077063 278 dbSNP
rs1179779259 282 dbSNP
rs555226234 283 dbSNP
rs1050162137 286 dbSNP
rs1413966224 286 dbSNP
rs534973342 286 dbSNP
rs997295637 286 dbSNP
rs111692195 293 dbSNP
rs901654880 298 dbSNP
rs1047712191 299 dbSNP
rs572720847 305 dbSNP
rs1036215570 307 dbSNP
rs923275349 310 dbSNP
rs976112434 311 dbSNP
rs1408277432 315 dbSNP
rs943460098 325 dbSNP
rs1437188119 334 dbSNP
rs1228142657 336 dbSNP
rs1311127424 337 dbSNP
rs1324046836 340 dbSNP
rs910706658 354 dbSNP
rs373522857 355 dbSNP
rs1173455908 359 dbSNP
rs1048343989 374 dbSNP
rs146325582 375 dbSNP
rs538257195 381 dbSNP
rs1411516200 382 dbSNP
rs1425553722 386 dbSNP
rs1245287778 387 dbSNP
rs1179178567 395 dbSNP
rs112464948 402 dbSNP
rs1427930965 402 dbSNP
rs977675509 407 dbSNP
rs191982757 423 dbSNP
rs1355344954 425 dbSNP
rs379291 433 dbSNP
rs1301519739 434 dbSNP
rs187226877 436 dbSNP
rs1297538727 451 dbSNP
rs1340789441 456 dbSNP
rs567384866 457 dbSNP
rs1279495857 459 dbSNP
rs577981388 460 dbSNP
rs1307772109 462 dbSNP
rs182069542 463 dbSNP
rs1006499911 469 dbSNP
rs1235561515 487 dbSNP
rs428602 512 dbSNP
rs1184077940 516 dbSNP
rs1047597710 525 dbSNP
rs1447663734 526 dbSNP
rs1170583394 539 dbSNP
rs1420481893 540 dbSNP
rs1414189085 556 dbSNP
rs1174363558 569 dbSNP
rs1237084318 571 dbSNP
rs748083356 572 dbSNP
rs1361210287 574 dbSNP
rs1470523714 575 dbSNP
rs1320387978 584 dbSNP
rs775815760 585 dbSNP
rs1335386477 586 dbSNP
rs929241196 590 dbSNP
rs1271497830 593 dbSNP
rs977623871 596 dbSNP
rs1218327892 605 dbSNP
rs901820541 611 dbSNP
rs1204065112 621 dbSNP
rs1267368036 623 dbSNP
rs1040804538 625 dbSNP
rs779038513 627 dbSNP
rs1011867630 642 dbSNP
rs1477750959 649 dbSNP
rs943466095 650 dbSNP
rs1427526932 652 dbSNP
rs1470472207 655 dbSNP
rs953011662 658 dbSNP
rs910663419 661 dbSNP
rs1387084353 663 dbSNP
rs1028687605 669 dbSNP
rs1319690512 670 dbSNP
rs997242268 676 dbSNP
rs1435171340 686 dbSNP
rs1223886654 688 dbSNP
rs1347024444 688 dbSNP
rs1420731223 688 dbSNP
rs990260948 691 dbSNP
rs771983081 707 dbSNP
rs924792404 709 dbSNP
rs1284904048 710 dbSNP
rs1157176911 714 dbSNP
rs1451038016 715 dbSNP
rs1219477922 719 dbSNP
rs1248655828 722 dbSNP
rs1480924038 725 dbSNP
rs1452684798 729 dbSNP
rs977641352 733 dbSNP
rs971669543 735 dbSNP
rs142162744 736 dbSNP
rs917571794 737 dbSNP
rs148347473 738 dbSNP
rs532595017 743 dbSNP
rs959144162 747 dbSNP
rs894464432 750 dbSNP
rs778812055 752 dbSNP
rs1240917015 760 dbSNP
rs938737719 761 dbSNP
rs928737144 762 dbSNP
rs1226675022 763 dbSNP
rs1294091125 769 dbSNP
rs1490568586 771 dbSNP
rs1005971249 779 dbSNP
rs1249930907 780 dbSNP
rs757248961 781 dbSNP
rs2836932 799 dbSNP
rs1237399754 800 dbSNP
rs1204329312 807 dbSNP
rs1350281811 808 dbSNP
rs1472135966 814 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions BC-1
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM796037. RNA binding protein: AGO2. Condition:4-Thiouridine ...

- Gottwein E; Corcoran DL; Mukherjee N; et al., 2011, Cell host & microbe.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' cgucGGUCGAGAUGGGGGCggu 5'
              | ||| :| ||||||   
Target 5' ---uCAAGCAUUUCCCCCG--- 3'
 		1 - 16
Article - Gottwein E; Corcoran DL; Mukherjee N; et al.
- Cell host & microbe, 2011
Primary effusion lymphoma (PEL) is caused by Kaposi's sarcoma-associated herpesvirus (KSHV) and frequently also harbors Epstein-Barr virus (EBV). The expression of KSHV- and EBV-encoded microRNAs (miRNAs) in PELs suggests a role for these miRNAs in latency and lymphomagenesis. Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites. In addition to a known viral analog of cellular miR-155, we show that KSHV encodes a viral miRNA that mimics cellular miR-142-3p function. In summary, this study identifies an extensive list of KSHV miRNA targets, which are likely to influence viral replication and pathogenesis.
LinkOut: [PMID: 22100165]
CLIP-seq Support 1 for dataset GSM796037
Method / RBP PAR-CLIP / AGO2
Cell line / Condition BC-1 / 4-Thiouridine
Location of target site ENST00000331573.3 | 3UTR | UCAAGCAUUUCCCCCG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 22100165 / GSE32109
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
90 hsa-miR-6787-5p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT449091 XPO6 exportin 6 2 2
MIRT449991 PSMG1 proteasome assembly chaperone 1 2 2
MIRT454608 MYADM myeloid associated differentiation marker 2 2
MIRT456116 VAV3 vav guanine nucleotide exchange factor 3 2 6
MIRT457064 TOR4A torsin family 4 member A 2 2
MIRT461023 SDF4 stromal cell derived factor 4 2 2
MIRT467197 SPRY4 sprouty RTK signaling antagonist 4 2 2
MIRT471711 OTUB1 OTU deubiquitinase, ubiquitin aldehyde binding 1 2 2
MIRT472566 NACC1 nucleus accumbens associated 1 2 2
MIRT476079 GRB2 growth factor receptor bound protein 2 2 2
MIRT480150 CALR calreticulin 2 2
MIRT483027 KHSRP KH-type splicing regulatory protein 2 4
MIRT483498 STMN3 stathmin 3 2 4
MIRT483728 THSD4 thrombospondin type 1 domain containing 4 2 2
MIRT484550 BARHL1 BarH like homeobox 1 2 6
MIRT484684 PACSIN1 protein kinase C and casein kinase substrate in neurons 1 2 2
MIRT486059 CTDNEP1 CTD nuclear envelope phosphatase 1 2 2
MIRT486116 INO80E INO80 complex subunit E 2 2
MIRT486313 SIPA1 signal-induced proliferation-associated 1 2 2
MIRT486525 CLCN7 chloride voltage-gated channel 7 2 2
MIRT486857 DPF1 double PHD fingers 1 2 2
MIRT487352 PHF15 jade family PHD finger 2 1 1
MIRT487582 FAM83H family with sequence similarity 83 member H 2 4
MIRT487792 GPR20 G protein-coupled receptor 20 2 4
MIRT488104 POU3F1 POU class 3 homeobox 1 2 2
MIRT488786 POFUT2 protein O-fucosyltransferase 2 2 2
MIRT489361 SYNGR1 synaptogyrin 1 2 4
MIRT489387 RAB11B RAB11B, member RAS oncogene family 2 2
MIRT489680 SCAMP4 secretory carrier membrane protein 4 2 2
MIRT489731 GNAI2 G protein subunit alpha i2 2 4
MIRT489750 TACC3 transforming acidic coiled-coil containing protein 3 2 2
MIRT490029 PCSK4 proprotein convertase subtilisin/kexin type 4 2 2
MIRT490379 LHFPL3 LHFPL tetraspan subfamily member 3 2 2
MIRT490580 SLC47A1 solute carrier family 47 member 1 2 2
MIRT490753 SRCIN1 SRC kinase signaling inhibitor 1 2 2
MIRT491187 JUND JunD proto-oncogene, AP-1 transcription factor subunit 2 4
MIRT491301 VGF VGF nerve growth factor inducible 2 2
MIRT491462 HOXB8 homeobox B8 2 2
MIRT491702 PDZD4 PDZ domain containing 4 2 2
MIRT491724 RTN4R reticulon 4 receptor 2 2
MIRT491737 SEMA3F semaphorin 3F 2 2
MIRT491984 UNK unkempt family zinc finger 2 2
MIRT492844 NRGN neurogranin 2 2
MIRT492936 NEUROD2 neuronal differentiation 2 2 4
MIRT493713 H2AFX H2A histone family member X 2 2
MIRT494623 ASB6 ankyrin repeat and SOCS box containing 6 2 4
MIRT494703 ARHGAP31 Rho GTPase activating protein 31 2 2
MIRT495602 NKX2-5 NK2 homeobox 5 2 2
MIRT495750 PDE4C phosphodiesterase 4C 2 4
MIRT500367 ZNF385A zinc finger protein 385A 2 2
MIRT501161 SLC10A7 solute carrier family 10 member 7 2 6
MIRT501702 PCGF3 polycomb group ring finger 3 2 6
MIRT504922 PDRG1 p53 and DNA damage regulated 1 2 2
MIRT517945 TRIM59 tripartite motif containing 59 2 2
MIRT524212 DDI2 DNA damage inducible 1 homolog 2 2 6
MIRT531186 SIGLEC12 sialic acid binding Ig like lectin 12 (gene/pseudogene) 2 2
MIRT531972 C12orf49 chromosome 12 open reading frame 49 2 2
MIRT558055 EVI5L ecotropic viral integration site 5 like 2 2
MIRT560482 LACE1 AFG1 like ATPase 2 2
MIRT563217 FXN frataxin 2 2
MIRT569095 FSCN1 fascin actin-bundling protein 1 2 2
MIRT569522 AP5Z1 adaptor related protein complex 5 zeta 1 subunit 2 2
MIRT569531 CTTN cortactin 2 2
MIRT569848 RGS5 regulator of G protein signaling 5 2 2
MIRT570738 ANKRD52 ankyrin repeat domain 52 2 2
MIRT574140 MARVELD1 MARVEL domain containing 1 2 2
MIRT615994 DHTKD1 dehydrogenase E1 and transketolase domain containing 1 2 2
MIRT628493 ZNF556 zinc finger protein 556 2 2
MIRT633451 KLLN killin, p53-regulated DNA replication inhibitor 2 2
MIRT649054 SLC1A2 solute carrier family 1 member 2 2 2
MIRT649340 HEXA hexosaminidase subunit alpha 2 2
MIRT670226 PTCHD1 patched domain containing 1 2 2
MIRT670666 KIAA1551 KIAA1551 2 2
MIRT671452 CDH7 cadherin 7 2 2
MIRT671729 ZNF451 zinc finger protein 451 2 2
MIRT690285 ZNF154 zinc finger protein 154 2 2
MIRT700575 PRSS22 protease, serine 22 2 2
MIRT701411 NKRF NFKB repressing factor 2 2
MIRT711877 VASP vasodilator stimulated phosphoprotein 2 2
MIRT712082 UNC13A unc-13 homolog A 2 2
MIRT712523 CYTH2 cytohesin 2 2 2
MIRT712751 GMDS GDP-mannose 4,6-dehydratase 2 2
MIRT714681 PRX periaxin 2 2
MIRT714718 VPS8 VPS8, CORVET complex subunit 2 2
MIRT717508 HRNR hornerin 2 2
MIRT717650 THBS2 thrombospondin 2 2 2
MIRT719592 PIAS4 protein inhibitor of activated STAT 4 2 2
MIRT720521 PTGR2 prostaglandin reductase 2 2 2
MIRT721295 C3orf36 chromosome 3 open reading frame 36 2 2
MIRT724922 VPS18 VPS18, CORVET/HOPS core subunit 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-6787 Ceritinib 57379345 NSC776422 approved sensitive High Non-Small Cell Lung Cancer cell line (H3122, H2228)
hsa-miR-6787-5p Dabrafenib 44462760 NSC764134 approved resistant High Melanoma cell line (A375, IGR37, 501Mel)
hsa-miR-6787-5p Vemurafenib 42611257 NSC761431 approved resistant High Melanoma cell line (A375, IGR37, 501Mel)
hsa-miR-6787-5p Cisplatin 5460033 NSC119875 approved sensitive cell line
hsa-miR-6787-5p Gefitinib 123631 NSC715055 approved resistant cell line (HCC827)
hsa-miR-6787-5p Tamoxifen 2733525 NSC180973 approved sensitive cell line (LCC2)
hsa-miR-6787-5p Osimertinib 71496458 NSC779217 approved sensitive cell line (H1975)
hsa-miR-6787-5p Paclitaxel 36314 NSC125973 approved resistant cell line (A2780)
hsa-miR-6787-5p Cisplatin 5460033 NSC119875 approved resistant cell line (A2780)
hsa-miR-6787-5p Docetaxel+Cisplatin+5-Fluorouracil resistant tissue (hypopharyngeal squamous cell carcinoma)

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