miRTarBase - #MIRT450233


—
pre-miRNA Information
pre-miRNA hsa-mir-4526   
Genomic Coordinates chr18: 13611114 - 13611200
Description Homo sapiens miR-4526 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-4526
Sequence 54| GCUGACAGCAGGGCUGGCCGCU |75
Evidence Experimental
Experiments Illumina
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1418307303 1 dbSNP
rs1168108556 5 dbSNP
rs1050044717 6 dbSNP
rs1250280154 7 dbSNP
rs370878033 10 dbSNP
rs1008988805 19 dbSNP
rs536331678 20 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol ZNF25   
Synonyms KOX19, Zfp9
Description zinc finger protein 25
Transcript NM_145011   
Expression
Putative miRNA Targets on ZNF25
3'UTR of ZNF25
(miRNA target sites are highlighted)		 
>ZNF25|NM_145011|3'UTR
   1 GATGAGTTGGGAAATTCTCTTGACTGAATTAATCCTTCAAAACAATCAGATAATTCACACAAGAGGTACACCTTATGAAT
  81 CGCATCAATAGAGGGAAATTTTCAGCTACAATCTTTGCTCTCTCTGTGTATCAGCAAATACATAGAGAGATTCTGTACAT
 161 TTATTTGGGAGAAAATTTTATCATATTTTAGGCTTTTCTAAATATTAGATAATATAGATGGCAGAAGTCATGCAAATTGT
 241 AAAACAGGAAGGAAACCTTTCAGAAGTCATACTTTTGTTTTGCAACATAGAAGTCACACAGGAGAAAAATCCTGTAAGTA
 321 AAACGAATGTCAAGACATTTTCTGTCAGGGCAGCCAGCTGTAGACATCCAAAAGCTCACAAATGAGAAGCTCCTTGAGTA
 401 TCTAGAAATCTCTTTACACAATTGGAGCTCATGTACTAGAGAATTCAAAGGGATAACTGCAAAGACACTGGTAGATATAG
 481 AAGCCTTTATTAAGAATTGATGTTTCATTCAATTTCAGATCACTGGTACTTGGATAGATATTTTAAATATTTGGAAGGTG
 561 TTCAATAAAAATTCAAATAATTTGTACTGAGGGAAACAGTTATACTACAAATCATGTTGCAGATCTGATGCCGAGATTGC
 641 TCTATTTTAAAAGGAAACCTGCAAATGTCTACATATATGAAGCTTTTAAAAAGCACAAGTTATCAGGCAACATCATTAAA
 721 CATACATTAAATGTCTGTTAGCATATAGGATTTTGTGCGTATGTGAGTGTGCTATAACATGTAACTTGCGGATGTTCAGC
 801 GTGCATGTGGAATCCATCCATAATGGTACATAGCGAAATAATATAATCTTAGTTCAGTAACTATTATGTGTATGAAGATG
 881 TTGCACATTAAGTCTCAGTAGTGACTCTGGTTGTTAATATTTGTATTGTAAGTGTAATATTCCTTTTAAATTATAAGGCA
 961 TCTTTTTATCCTTTTTTGTGTTTGTAAATGGATATAGACAGTGGTAATAACTAATCCTTCAAAAATAAGTTAAAATGTTT
1041 TTGTAAAATTTTCAAATGTCAGTCAAGTTTTGCATTAGGGACACATTTATATATAGCAAAAGCCTGAGCTGTTTTTAAAC
1121 AGCTAAAAACAGTAGTATTTATTACAATCTCCACAATGAAAACAAATAGTGCAATGTAAGAAATATTATGTATCTTACTG
1201 TTGATGTGTGAGCAGGGAGCAGAGCTATCTGCATTTGTATTTAGTGTGAGAGTCCTAAATGTTCTTCACCAACTTTTTCT
1281 TCCTCATAGAAGCAACATGGCATAGTTAAGGGTGTGGACTCTGGGCTCCTGCTGCCTGGGCCCCGATTCCAGCATGGGGC
1361 ATGCTACTTAATATCTCTGTGCCTCAGTTCCCATCCCATAAAAGAGTAGTGATAGTGACAACATCTTAGGATTGCTTTGA
1441 GGTCTAAATGAGTTAACATTTTCAAAGCACTTAGAATAGTGTCTGAGACACAAGAGCTATATGTTAGAGGTTATCATCAT
1521 TATTTGTATTTTGTGAATTACGCTGCAAAAAAAAAAAAAATGTTGGCTACCCAACATTCATTCCCCACCTTCTTGCTGCC
1601 AGTGCCTTGATTTGGTTGTTTGTTGTTTGTTTGTTTTCCTACAAGTGATTTAGGGGCAGATCCTGACTACACTAAGTCAG
1681 GGTTTGACAAATGACAGTCCATCAGACAGATCTGGCCCACTACCCATTTTTGTATCCTGCAAGCTAAGAATGGTTTTATA
1761 TTTCTAAATGGTTGAAAGAATCAAAGAATATTGTGACACATGAAAATTATATGATATTCAAATTTCAGTGTCCATAAATA
1841 AAGTTTTGAAAACATGAATACAAACAAAAAACACCTATTTATGTTTGACCTGTGGCTGTCTTTGCACTACCCCAGCAGAG
1921 TTGAGTAGTTGTAGCAGACACCACATGCCCTTGAGCCTAAGATCTAGCACTTTACAAAGTAAGTTTTTCTGTTACTTAGA
2001 GCTGAAAATAAAAGCAATGTAGAGTTACGCTTTTATAAGTATTTCATGTTTCAGAAATGATGCATACAGCAATTTGTAGG
2081 TGGGTGGTTTTTTGCAGTATATTTATTTTGTGCATTATATTTATATGTTAAGAGCCTGAGCTTAGAAGTATTTTTTTCAA
2161 AGAAATGTGTTTTTTACTTGCTAAATTGTCATAACATCAAAACAAGAAATTTCTTGATGGAATGTAGCAGTAAACATATG
2241 AAATAAACATTGTCTAAATTAAGTCGAATTGTTCATTGATACTGCCCCACAGTATTCCTTTGTTTTCTCCCAAATCAATG
2321 GCCAGTTTTCCCTGTATCATTTTATAATTTTCTTTCTATCCCATAAGATACCATTGGTAAGTCATACTTAGCTAACGTAA
2401 CCCAATAACAAAAAACTTACAATACCCAATTCCATCAGCTACATTACTAGTAATCTATAAAATTATTGCCTGCACTTCAT
2481 GTAATTGTCATATGCTGCTACAATCTAAACCTGCCAGCGTCTTACTTCCCCTTCCTAATAAAGACTTTCATTGAT
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' ucGCCGGUCGG--GACGACAGUCg 5'
            :| | || |  :| ||||||| 
Target 5' aaTGTCAAGACATTTTCTGTCAGg 3'
 326 - 349 150.00 -13.30
2 
miRNA  3' ucgccGGUCG--GGACGACAGUCg 5'
               ||| |  |:||||| ||| 
Target 5' attccCCACCTTCTTGCTGCCAGt 3'
 1580 - 1603 131.00 -16.90
3 
miRNA  3' ucgccggucgggAC-GACAGUCg 5'
                      || ||||:|| 
Target 5' acatacattaaaTGTCTGTTAGc 3'
 720 - 742 126.00 -11.80
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN13271930 9 COSMIC
COSN31553899 49 COSMIC
COSN30524513 70 COSMIC
COSN30561147 73 COSMIC
COSN22044723 82 COSMIC
COSN30459007 124 COSMIC
COSN23574923 134 COSMIC
COSN30114555 174 COSMIC
COSN16688276 268 COSMIC
COSN10067104 427 COSMIC
COSN31581682 809 COSMIC
COSN25191017 1094 COSMIC
COSN25791720 1130 COSMIC
COSN6071015 1400 COSMIC
COSN20721177 1439 COSMIC
COSN20107037 1547 COSMIC
COSN8639702 1633 COSMIC
COSN31593259 1705 COSMIC
COSN31588792 1875 COSMIC
COSN32062463 1903 COSMIC
COSN26552794 1968 COSMIC
COSN24303523 1997 COSMIC
COSN6071014 2062 COSMIC
COSN17884949 2142 COSMIC
COSN19660183 2181 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1466154149 1 dbSNP
rs1425879042 3 dbSNP
rs1186070115 4 dbSNP
rs1423518908 5 dbSNP
rs765463116 7 dbSNP
rs966375067 8 dbSNP
rs1184005580 10 dbSNP
rs1175312495 12 dbSNP
rs762239085 13 dbSNP
rs1257926022 17 dbSNP
rs1199841445 19 dbSNP
rs1319309745 20 dbSNP
rs777345062 25 dbSNP
rs1243580232 30 dbSNP
rs764496247 31 dbSNP
rs1314465898 34 dbSNP
rs926124359 40 dbSNP
rs1389408751 45 dbSNP
rs374362998 50 dbSNP
rs769817470 52 dbSNP
rs1041877107 58 dbSNP
rs1238548432 59 dbSNP
rs112851311 61 dbSNP
rs147942111 63 dbSNP
rs745948323 69 dbSNP
rs756398453 72 dbSNP
rs536281838 76 dbSNP
rs976349689 79 dbSNP
rs182163191 81 dbSNP
rs546963882 87 dbSNP
rs967837083 88 dbSNP
rs911175015 91 dbSNP
rs1011608058 92 dbSNP
rs983992282 93 dbSNP
rs753840132 96 dbSNP
rs1002850023 98 dbSNP
rs952670158 108 dbSNP
rs1277180130 113 dbSNP
rs3167948 116 dbSNP
rs370097559 117 dbSNP
rs1025445472 119 dbSNP
rs1410144068 122 dbSNP
rs527401689 132 dbSNP
rs1219144300 142 dbSNP
rs1235307830 143 dbSNP
rs1442428095 144 dbSNP
rs1328599718 145 dbSNP
rs1332168951 145 dbSNP
rs760814651 147 dbSNP
rs907459127 151 dbSNP
rs1273376999 155 dbSNP
rs1341768340 157 dbSNP
rs1044653116 160 dbSNP
rs948907550 165 dbSNP
rs909373243 181 dbSNP
rs1215629504 182 dbSNP
rs1268039999 185 dbSNP
rs993995300 198 dbSNP
rs781617219 202 dbSNP
rs1024392522 204 dbSNP
rs746204063 208 dbSNP
rs1243583998 209 dbSNP
rs757768078 213 dbSNP
rs1350055358 218 dbSNP
rs1421019653 220 dbSNP
rs918991425 221 dbSNP
rs1014298191 222 dbSNP
rs894467014 224 dbSNP
rs976167117 236 dbSNP
rs570967812 239 dbSNP
rs910492555 245 dbSNP
rs1328606999 252 dbSNP
rs1400956733 257 dbSNP
rs986007947 263 dbSNP
rs145320581 267 dbSNP
rs1338696374 282 dbSNP
rs747459017 285 dbSNP
rs1056081131 288 dbSNP
rs778141400 289 dbSNP
rs1355585688 294 dbSNP
rs1333500999 299 dbSNP
rs140701576 300 dbSNP
rs1386882081 309 dbSNP
rs116213731 321 dbSNP
rs1041856131 324 dbSNP
rs1418172798 325 dbSNP
rs1260611839 328 dbSNP
rs945790123 331 dbSNP
rs1188089318 336 dbSNP
rs1367325879 339 dbSNP
rs190802919 344 dbSNP
rs1162016657 346 dbSNP
rs2472144 348 dbSNP
rs1387770453 351 dbSNP
rs758730138 351 dbSNP
rs922397592 359 dbSNP
rs529316066 362 dbSNP
rs752342074 369 dbSNP
rs185943216 373 dbSNP
rs942400797 375 dbSNP
rs910871036 377 dbSNP
rs984455672 393 dbSNP
rs1044703566 395 dbSNP
rs931209273 414 dbSNP
rs201863197 416 dbSNP
rs1215637556 422 dbSNP
rs181011367 440 dbSNP
rs147247280 445 dbSNP
rs558280906 446 dbSNP
rs970539949 456 dbSNP
rs1255005858 459 dbSNP
rs1421611180 464 dbSNP
rs1183333895 468 dbSNP
rs567943781 475 dbSNP
rs1382713826 478 dbSNP
rs1207177300 481 dbSNP
rs1024423557 485 dbSNP
rs1158451478 485 dbSNP
rs992894410 493 dbSNP
rs919030714 496 dbSNP
rs958712169 500 dbSNP
rs1034323245 502 dbSNP
rs1394381032 509 dbSNP
rs1330904486 511 dbSNP
rs910209602 533 dbSNP
rs1000863817 538 dbSNP
rs545229836 547 dbSNP
rs1283612242 555 dbSNP
rs1349832944 557 dbSNP
rs967940081 565 dbSNP
rs1431417863 571 dbSNP
rs1020953388 573 dbSNP
rs1010439569 575 dbSNP
rs576144667 576 dbSNP
rs901339512 580 dbSNP
rs1238210873 586 dbSNP
rs1458623911 591 dbSNP
rs556452089 593 dbSNP
rs942423369 596 dbSNP
rs889455568 601 dbSNP
rs1048018748 611 dbSNP
rs988390345 613 dbSNP
rs547908758 614 dbSNP
rs918545182 620 dbSNP
rs1172940679 627 dbSNP
rs536179837 632 dbSNP
rs971438957 633 dbSNP
rs1373075956 638 dbSNP
rs1387147607 638 dbSNP
rs567191505 639 dbSNP
rs1310105400 650 dbSNP
rs973047676 659 dbSNP
rs1394925649 661 dbSNP
rs1196196884 669 dbSNP
rs1236902578 672 dbSNP
rs1489717043 677 dbSNP
rs763524050 678 dbSNP
rs553358508 683 dbSNP
rs888043491 693 dbSNP
rs533496375 696 dbSNP
rs1459485641 702 dbSNP
rs917732372 703 dbSNP
rs1431785060 710 dbSNP
rs992925779 720 dbSNP
rs571054110 722 dbSNP
rs897990282 723 dbSNP
rs1040561148 724 dbSNP
rs1186546010 726 dbSNP
rs1458309655 730 dbSNP
rs1476046836 731 dbSNP
rs1244375565 735 dbSNP
rs944478549 743 dbSNP
rs1365288464 758 dbSNP
rs41314970 759 dbSNP
rs1278509943 762 dbSNP
rs1339382238 765 dbSNP
rs531966328 767 dbSNP
rs866867131 771 dbSNP
rs1223014073 778 dbSNP
rs1265345351 781 dbSNP
rs969117016 789 dbSNP
rs7095006 790 dbSNP
rs143887449 796 dbSNP
rs753389255 800 dbSNP
rs529629232 801 dbSNP
rs1415993412 804 dbSNP
rs555205141 805 dbSNP
rs1364141960 820 dbSNP
rs1348035522 826 dbSNP
rs1295389644 830 dbSNP
rs1298510770 832 dbSNP
rs1359530254 833 dbSNP
rs540679712 834 dbSNP
rs889570899 835 dbSNP
rs1371466236 838 dbSNP
rs1327601539 843 dbSNP
rs41306330 848 dbSNP
rs1348901845 855 dbSNP
rs1320386056 859 dbSNP
rs1170674314 863 dbSNP
rs1411205913 865 dbSNP
rs971491049 867 dbSNP
rs537618915 868 dbSNP
rs931021662 872 dbSNP
rs1214783449 878 dbSNP
rs1239401108 879 dbSNP
rs796188959 892 dbSNP
rs1181294420 905 dbSNP
rs760708317 912 dbSNP
rs896795427 923 dbSNP
rs1379505636 926 dbSNP
rs570284050 928 dbSNP
rs1036969534 934 dbSNP
rs949254389 936 dbSNP
rs917764872 937 dbSNP
rs1054927029 940 dbSNP
rs1446674223 951 dbSNP
rs1300501466 969 dbSNP
rs759150342 971 dbSNP
rs1310603995 978 dbSNP
rs762173800 978 dbSNP
rs1353488934 980 dbSNP
rs1205472000 984 dbSNP
rs927436047 985 dbSNP
rs979243483 987 dbSNP
rs564638336 988 dbSNP
rs1312923483 993 dbSNP
rs1209542562 996 dbSNP
rs1235755464 999 dbSNP
rs767462493 1003 dbSNP
rs1179218290 1004 dbSNP
rs1237485956 1006 dbSNP
rs1019114177 1009 dbSNP
rs1008994840 1012 dbSNP
rs544359299 1013 dbSNP
rs1208605 1020 dbSNP
rs1348441891 1030 dbSNP
rs946406574 1031 dbSNP
rs774681865 1034 dbSNP
rs1446845200 1036 dbSNP
rs965558845 1042 dbSNP
rs1305398027 1052 dbSNP
rs148118460 1056 dbSNP
rs1366619332 1058 dbSNP
rs1298452769 1059 dbSNP
rs1208604 1063 dbSNP
rs1218910190 1066 dbSNP
rs1368174763 1073 dbSNP
rs954340767 1079 dbSNP
rs543308758 1086 dbSNP
rs1429705414 1089 dbSNP
rs1320172314 1098 dbSNP
rs12572117 1104 dbSNP
rs995640274 1105 dbSNP
rs927849276 1117 dbSNP
rs776705962 1120 dbSNP
rs1037071479 1130 dbSNP
rs1247021337 1132 dbSNP
rs947857229 1141 dbSNP
rs1189139507 1145 dbSNP
rs144752614 1147 dbSNP
rs952059250 1150 dbSNP
rs747553011 1156 dbSNP
rs1326079729 1167 dbSNP
rs972434041 1170 dbSNP
rs1436196499 1172 dbSNP
rs1281676191 1178 dbSNP
rs749420476 1192 dbSNP
rs1481708109 1198 dbSNP
rs1277605325 1200 dbSNP
rs533580039 1203 dbSNP
rs937857676 1210 dbSNP
rs13503 1212 dbSNP
rs1043168382 1216 dbSNP
rs1450888672 1217 dbSNP
rs1486024190 1218 dbSNP
rs1282450369 1225 dbSNP
rs770037844 1226 dbSNP
rs1230964657 1238 dbSNP
rs1477920110 1243 dbSNP
rs758746260 1245 dbSNP
rs1192327227 1252 dbSNP
rs56963126 1261 dbSNP
rs1473474307 1285 dbSNP
rs913233148 1286 dbSNP
rs1392063125 1287 dbSNP
rs1028735642 1288 dbSNP
rs1348194645 1296 dbSNP
rs1362729118 1297 dbSNP
rs988809120 1300 dbSNP
rs1297801006 1302 dbSNP
rs1324803487 1307 dbSNP
rs1414919263 1317 dbSNP
rs1284770217 1320 dbSNP
rs1376727320 1320 dbSNP
rs1208603 1321 dbSNP
rs1355472748 1323 dbSNP
rs1243539000 1324 dbSNP
rs1287830711 1325 dbSNP
rs965339832 1331 dbSNP
rs1052128006 1332 dbSNP
rs1259226119 1337 dbSNP
rs1443695687 1341 dbSNP
rs541156229 1343 dbSNP
rs1369556814 1344 dbSNP
rs999569470 1345 dbSNP
rs1162089461 1347 dbSNP
rs1358962961 1349 dbSNP
rs1420661016 1356 dbSNP
rs537565430 1357 dbSNP
rs906479809 1359 dbSNP
rs1397873713 1361 dbSNP
rs1046329365 1366 dbSNP
rs954254595 1371 dbSNP
rs568899161 1372 dbSNP
rs1311325227 1374 dbSNP
rs1735585 1375 dbSNP
rs1048223230 1376 dbSNP
rs1735584 1377 dbSNP
rs1258592249 1396 dbSNP
rs1259702982 1398 dbSNP
rs961378027 1400 dbSNP
rs113995300 1403 dbSNP
rs1254813685 1404 dbSNP
rs1261122185 1404 dbSNP
rs1345098403 1412 dbSNP
rs1182336942 1422 dbSNP
rs920651723 1424 dbSNP
rs11011410 1425 dbSNP
rs1326784851 1435 dbSNP
rs1267165668 1437 dbSNP
rs779076244 1444 dbSNP
rs1467730338 1449 dbSNP
rs1173353197 1463 dbSNP
rs972102128 1467 dbSNP
rs567212736 1469 dbSNP
rs896141943 1470 dbSNP
rs1055072718 1474 dbSNP
rs1468292120 1476 dbSNP
rs754670303 1480 dbSNP
rs1377468671 1491 dbSNP
rs7477328 1497 dbSNP
rs1445774702 1500 dbSNP
rs1233515988 1501 dbSNP
rs1241593887 1502 dbSNP
rs34781020 1507 dbSNP
rs1332487678 1508 dbSNP
rs1255023813 1510 dbSNP
rs1336748054 1514 dbSNP
rs1320882523 1521 dbSNP
rs1356819850 1523 dbSNP
rs1309887700 1525 dbSNP
rs753380532 1530 dbSNP
rs1002508658 1537 dbSNP
rs868125243 1541 dbSNP
rs547299171 1542 dbSNP
rs1379032525 1546 dbSNP
rs1289932402 1558 dbSNP
rs1435245790 1558 dbSNP
rs374283144 1559 dbSNP
rs1413476655 1561 dbSNP
rs1468308557 1561 dbSNP
rs34503699 1561 dbSNP
rs35754665 1561 dbSNP
rs369819631 1561 dbSNP
rs397845420 1561 dbSNP
rs397846670 1561 dbSNP
rs1043908454 1562 dbSNP
rs1491447029 1562 dbSNP
rs912169327 1570 dbSNP
rs1392672135 1577 dbSNP
rs1300238507 1585 dbSNP
rs1343194354 1586 dbSNP
rs1219939853 1587 dbSNP
rs533395964 1614 dbSNP
rs987678885 1615 dbSNP
rs988527651 1619 dbSNP
rs1462106211 1621 dbSNP
rs953597634 1625 dbSNP
rs1250122314 1631 dbSNP
rs1489703307 1637 dbSNP
rs1210748499 1663 dbSNP
rs1370288411 1671 dbSNP
rs1479554220 1681 dbSNP
rs1195966875 1692 dbSNP
rs572151153 1694 dbSNP
rs1427964276 1696 dbSNP
rs1168324243 1701 dbSNP
rs1370106397 1704 dbSNP
rs1458234029 1705 dbSNP
rs1302232389 1710 dbSNP
rs1011008160 1712 dbSNP
rs1423283388 1719 dbSNP
rs957827573 1720 dbSNP
rs1262400185 1726 dbSNP
rs35673794 1734 dbSNP
rs891908296 1742 dbSNP
rs1190417157 1756 dbSNP
rs755656310 1765 dbSNP
rs1294074407 1766 dbSNP
rs944064846 1771 dbSNP
rs750438443 1772 dbSNP
rs767552317 1784 dbSNP
rs149398616 1796 dbSNP
rs550919789 1799 dbSNP
rs1264169387 1807 dbSNP
rs1263203957 1818 dbSNP
rs1184798743 1829 dbSNP
rs1243485670 1835 dbSNP
rs920109596 1838 dbSNP
rs147787958 1843 dbSNP
rs367549565 1843 dbSNP
rs974686718 1854 dbSNP
rs1162721717 1860 dbSNP
rs906189199 1861 dbSNP
rs961560940 1871 dbSNP
rs1421283877 1875 dbSNP
rs1015381898 1876 dbSNP
rs1344175624 1880 dbSNP
rs1428039980 1885 dbSNP
rs1304036888 1889 dbSNP
rs991891297 1896 dbSNP
rs1381992374 1898 dbSNP
rs201819379 1904 dbSNP
rs960381082 1905 dbSNP
rs1363477345 1908 dbSNP
rs530592890 1924 dbSNP
rs1357834446 1931 dbSNP
rs1033318636 1932 dbSNP
rs1242754977 1941 dbSNP
rs1287028169 1943 dbSNP
rs778361556 1946 dbSNP
rs757806042 1947 dbSNP
rs1022202011 1951 dbSNP
rs1009842201 1953 dbSNP
rs920717250 1957 dbSNP
rs1457517743 1961 dbSNP
rs1441328429 1963 dbSNP
rs1373711328 1970 dbSNP
rs530920669 1982 dbSNP
rs1406827091 1988 dbSNP
rs1398541054 1989 dbSNP
rs866080748 1989 dbSNP
rs1177759252 1991 dbSNP
rs1359279986 2004 dbSNP
rs1170416127 2019 dbSNP
rs1447520294 2020 dbSNP
rs138917455 2028 dbSNP
rs145158076 2029 dbSNP
rs911902435 2033 dbSNP
rs1453085200 2036 dbSNP
rs944096028 2046 dbSNP
rs573488321 2054 dbSNP
rs1264890136 2059 dbSNP
rs141438573 2067 dbSNP
rs540113835 2072 dbSNP
rs188539712 2078 dbSNP
rs932665823 2079 dbSNP
rs184257055 2080 dbSNP
rs1459001051 2086 dbSNP
rs958429710 2087 dbSNP
rs974339736 2102 dbSNP
rs1468384181 2103 dbSNP
rs1192636690 2106 dbSNP
rs1030790247 2110 dbSNP
rs1297468336 2114 dbSNP
rs1235534923 2116 dbSNP
rs1173547610 2123 dbSNP
rs978239114 2127 dbSNP
rs1467600196 2133 dbSNP
rs556940890 2138 dbSNP
rs1024647858 2158 dbSNP
rs1330117557 2158 dbSNP
rs970469136 2158 dbSNP
rs1276842704 2160 dbSNP
rs940208328 2170 dbSNP
rs908689058 2174 dbSNP
rs1281396591 2176 dbSNP
rs776801819 2177 dbSNP
rs1320063100 2185 dbSNP
rs537807025 2194 dbSNP
rs1272201504 2196 dbSNP
rs1435925342 2201 dbSNP
rs764700542 2203 dbSNP
rs1246934527 2206 dbSNP
rs749566092 2206 dbSNP
rs1427774763 2213 dbSNP
rs1389524498 2228 dbSNP
rs771046340 2231 dbSNP
rs991922573 2235 dbSNP
rs1477845450 2238 dbSNP
rs1169055938 2249 dbSNP
rs1419352967 2265 dbSNP
rs191960056 2266 dbSNP
rs1026888584 2267 dbSNP
rs1366448711 2275 dbSNP
rs1033351134 2277 dbSNP
rs995372758 2279 dbSNP
rs1478921059 2289 dbSNP
rs1342528556 2290 dbSNP
rs896975967 2292 dbSNP
rs555432494 2294 dbSNP
rs1197734354 2296 dbSNP
rs967724843 2311 dbSNP
rs1208602 2319 dbSNP
rs772633315 2330 dbSNP
rs1009461695 2345 dbSNP
rs892312511 2358 dbSNP
rs1018698589 2363 dbSNP
rs1358438742 2373 dbSNP
rs1219849382 2381 dbSNP
rs1264862230 2383 dbSNP
rs1202456011 2391 dbSNP
rs1191764920 2396 dbSNP
rs890518310 2397 dbSNP
rs1008268881 2402 dbSNP
rs1482427725 2409 dbSNP
rs1274620735 2412 dbSNP
rs1201522402 2416 dbSNP
rs1474682928 2416 dbSNP
rs891250554 2417 dbSNP
rs544864107 2419 dbSNP
rs567048701 2420 dbSNP
rs931973837 2421 dbSNP
rs997284826 2425 dbSNP
rs779353939 2426 dbSNP
rs1382855136 2432 dbSNP
rs1317684874 2440 dbSNP
rs1324642331 2442 dbSNP
rs1450187341 2446 dbSNP
rs1315610414 2448 dbSNP
rs990136443 2455 dbSNP
rs1243421775 2457 dbSNP
rs137858502 2463 dbSNP
rs940228700 2467 dbSNP
rs924113433 2473 dbSNP
rs908720381 2503 dbSNP
rs1204060120 2516 dbSNP
rs1281580606 2518 dbSNP
rs1056608719 2519 dbSNP
rs1408132529 2525 dbSNP
rs939490183 2528 dbSNP
rs1444416715 2529 dbSNP
rs753547114 2534 dbSNP
rs1182064563 2536 dbSNP
rs1382437657 2551 dbSNP
rs1454457194 2552 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions BC-1
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM796037. RNA binding protein: AGO2. Condition:4-Thiouridine ...

- Gottwein E; Corcoran DL; Mukherjee N; et al., 2011, Cell host & microbe.

Article - Gottwein E; Corcoran DL; Mukherjee N; et al.
- Cell host & microbe, 2011
Primary effusion lymphoma (PEL) is caused by Kaposi's sarcoma-associated herpesvirus (KSHV) and frequently also harbors Epstein-Barr virus (EBV). The expression of KSHV- and EBV-encoded microRNAs (miRNAs) in PELs suggests a role for these miRNAs in latency and lymphomagenesis. Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites. In addition to a known viral analog of cellular miR-155, we show that KSHV encodes a viral miRNA that mimics cellular miR-142-3p function. In summary, this study identifies an extensive list of KSHV miRNA targets, which are likely to influence viral replication and pathogenesis.
LinkOut: [PMID: 22100165]
CLIP-seq Support 1 for dataset GSM796037
Method / RBP PAR-CLIP / AGO2
Cell line / Condition BC-1 / 4-Thiouridine
Location of target site ENST00000302609.7 | 3UTR | UCAAGACAUUUUCUGU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 22100165 / GSE32109
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
60 hsa-miR-4526 Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT080216 PRKACB protein kinase cAMP-activated catalytic subunit beta 2 2
MIRT100350 DDX39B DExD-box helicase 39B 2 2
MIRT445480 KDM6A lysine demethylase 6A 2 2
MIRT450233 ZNF25 zinc finger protein 25 2 2
MIRT465783 TMOD3 tropomodulin 3 2 8
MIRT466253 TMBIM6 transmembrane BAX inhibitor motif containing 6 2 2
MIRT470395 PPP1R16B protein phosphatase 1 regulatory subunit 16B 2 2
MIRT470442 PPP1R15B protein phosphatase 1 regulatory subunit 15B 2 8
MIRT476323 GLTSCR1L BRD4 interacting chromatin remodeling complex associated protein like 2 2
MIRT479706 CCNT1 cyclin T1 2 2
MIRT481925 ANKRD33B ankyrin repeat domain 33B 2 2
MIRT484016 ZNF776 zinc finger protein 776 2 4
MIRT497022 INO80B INO80 complex subunit B 2 2
MIRT502526 EPHA2 EPH receptor A2 2 4
MIRT513497 SSR1 signal sequence receptor subunit 1 2 6
MIRT517846 RPS4X ribosomal protein S4, X-linked 2 4
MIRT533734 TMEM200C transmembrane protein 200C 2 2
MIRT535904 MKNK2 MAP kinase interacting serine/threonine kinase 2 2 2
MIRT537537 EZR ezrin 2 2
MIRT538756 CACUL1 CDK2 associated cullin domain 1 2 2
MIRT540307 GFPT1 glutamine--fructose-6-phosphate transaminase 1 2 2
MIRT545510 EPT1 selenoprotein I 2 2
MIRT548829 CHIC1 cysteine rich hydrophobic domain 1 2 2
MIRT569600 TRIM29 tripartite motif containing 29 2 2
MIRT572462 ZNF516 zinc finger protein 516 2 2
MIRT575457 Ints2 integrator complex subunit 2 2 3
MIRT609411 SLC25A45 solute carrier family 25 member 45 2 2
MIRT609622 TRPC4AP transient receptor potential cation channel subfamily C member 4 associated protein 2 2
MIRT609666 INTS2 integrator complex subunit 2 2 3
MIRT609994 PIGS phosphatidylinositol glycan anchor biosynthesis class S 2 2
MIRT611691 NODAL nodal growth differentiation factor 2 2
MIRT615720 BACE2 beta-site APP-cleaving enzyme 2 2 2
MIRT616383 C1orf87 chromosome 1 open reading frame 87 2 2
MIRT616593 KLHL9 kelch like family member 9 2 2
MIRT628162 HIP1 huntingtin interacting protein 1 2 2
MIRT628376 CAMK2N1 calcium/calmodulin dependent protein kinase II inhibitor 1 2 2
MIRT629203 PAPOLA poly(A) polymerase alpha 2 2
MIRT635006 ADPRH ADP-ribosylarginine hydrolase 2 2
MIRT645493 TRIM63 tripartite motif containing 63 2 2
MIRT646750 MUC4 mucin 4, cell surface associated 2 2
MIRT649613 ITPKC inositol-trisphosphate 3-kinase C 2 2
MIRT656228 MFSD6 major facilitator superfamily domain containing 6 2 2
MIRT658196 FBXO44 F-box protein 44 2 2
MIRT661757 MICA MHC class I polypeptide-related sequence A 2 2
MIRT662866 UPF3A UPF3A, regulator of nonsense mediated mRNA decay 2 2
MIRT666738 RALY RALY heterogeneous nuclear ribonucleoprotein 2 2
MIRT690391 PARP15 poly(ADP-ribose) polymerase family member 15 2 2
MIRT699795 SEC24A SEC24 homolog A, COPII coat complex component 2 2
MIRT700033 RPL22 ribosomal protein L22 2 2
MIRT701741 MTDH metadherin 2 2
MIRT702330 KMT2A lysine methyltransferase 2A 2 2
MIRT702672 IRS2 insulin receptor substrate 2 2 2
MIRT708730 LSAMP limbic system-associated membrane protein 2 2
MIRT709230 GPSM2 G protein signaling modulator 2 2 2
MIRT717503 UFL1 UFM1 specific ligase 1 2 2
MIRT718533 PIGQ phosphatidylinositol glycan anchor biosynthesis class Q 2 2
MIRT719845 MON1B MON1 homolog B, secretory trafficking associated 2 2
MIRT720957 TMEM151B transmembrane protein 151B 2 2
MIRT724816 MSX2 msh homeobox 2 2 2
MIRT725369 MTF2 metal response element binding transcription factor 2 2 2
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-4 Dexamethasone approved 5743 Microarray primary rat thymocytes 20847043 2010 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-4526 Cisplatin 5460033 NSC119875 approved resistant cell line (BxPC3)
hsa-miR-4526 Gefitinib 123631 NSC715055 approved resistant cell line (PC9)
hsa-miR-4526 Osimertinib 71496458 NSC779217 approved resistant cell line (PC9)
hsa-miR-4526 Platinum 23939 resistant tissue (non-small cell lung cancer)
hsa-miR-4526 Gemcitabine 60750 NSC613327 approved sensitive cell line (PANC-1) (100 ng/ml)

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