miRTarBase - #MIRT450265


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pre-miRNA Information
pre-miRNA hsa-mir-4677   
Genomic Coordinates chr1: 243346176 - 243346255
Description Homo sapiens miR-4677 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-4677-5p
Sequence 13| UUGUUCUUUGGUCUUUCAGCCA |34
Evidence Experimental
Experiments Illumina
DRVs in miRNA
Mutant ID Mutant Position Mutant Source
COSN10045564 8 COSMIC
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1050583047 19 dbSNP
rs1425855779 21 dbSNP
Putative Targets

Gene Information
Gene Symbol F2RL2   
Synonyms PAR-3, PAR3
Description coagulation factor II thrombin receptor like 2
Transcript NM_004101   
Expression
Putative miRNA Targets on F2RL2
3'UTR of F2RL2
(miRNA target sites are highlighted)		 
>F2RL2|NM_004101|3'UTR
   1 TGAAATGATCTTAGAGAACAAGGACAGCCATCACAGAGAACGTCTGTTTTCAAGAACAACATAAGCATAGTGCAAGGAGC
  81 TCCATTTCCGAGCTCCTAAGAAATATGCTTCAAAGGTCAAACATTACAAAAGCATTAGTAGTTTGTTTGTTTGTTTTTGA
 161 GACTGAGTCTCACTTTATCACCCAGACTGGCGTGCAGTGGCACTATCTTGGCTCATTGCAACCTCTGCCTCCCAGGTCAG
 241 CCTCCCAAGTAGCTGGGATTACACCACCATGCCCAGCTACTAAAAATACTTGTATTTTTAGTAGAGACGGGGTTTCACCA
 321 TGTTGACCAGGCTGGTCTTGAACTCCTGACCTCAAGTGATCTTCCGGCCTCAGCCTCCCAAAGTGCTGGATTACAGGCGT
 401 GAGCCACTGAGCCAGCCAGCATTAGTAATTTTTAAAAACACTTTATCAGTATTTTAAAAATGTTAATGCAGGAGAAAAGA
 481 TATCACAACTCTATGGAAAATGACATTTCCATTTGCCTTATTGCTACTTCAAGCTCTTTAAATCACCATCTTCCCTATTT
 561 CTGTGAGTGGTATTGCCATCCTTGACATTTGACATCATTTTTTATTCTTTGGTCTCTTTTGACTCTCATGCTGGTGGCTG
 641 CCTCATCAACTGATTCTATCTTTGTAGGGTCCCTCACCAGGGTCTTTTATCTAGTTTCACCTTTGCCTTCTTTTTTCCTT
 721 TTTTTAATAGAGACAGTGTCTCGCTTCGTCACCTGGCTGAAGTGCAGTAGCCTGATCATAGCTCACTTCAGCCTCCAACT
 801 CCTGGGCTCAAGCAATCCTGCTGTCTCAGCCTCCCAAGTAACTAAGACTACAGGCATGCACCACCATACCCAACTAATTT
 881 TATTTTTTATTTTTTGCAGAGATGGAGTCTCACTGTTGCCCAGGCTGGTCTTGAACTCCTGGTCTCGAGTGATCTTCCTA
 961 TCTCAGCCTCCCAAAGTGCTGGGACTACAGGCATGAGCCACTACGTCCAGGCCACCTCTACCTTCTAACCATTCTCTCCA
1041 CTGCCAGCCTACCCTCCACCACTTCACAAGTCCTGCCAGATTAATCTTCCTTAGATATCAGTTAGGATACATCACTAAAA
1121 CATTTCCACTAACTCCACTGTTTCTATAATAAATCATAAATCTTTAGCCTGGCATTCAAGGCTAACTTGCTAATCACACT
1201 TCCCATTAAACCTTGCTTATGATATAGGCACCAACCAAACCTCTTGCTCTGCTATATCTCCACTCTGCCTCAGACTGAAA
1281 AGCTAGTCCTAACGTCTTTGCCTTAATTCTGTTCATTTTTTCAAGTCCTTGAAGGACCATTCTTCCCTGATTCTCAGGCT
1361 AGAAGTGTCACTTTTCTTATCTGTACTTCCAAAGCACTTTCGTATATTTTTATTATGGCATTTATATATAGTTCATTTAT
1441 ATTTAAATTTTAATTCCATGAACAATCAAGTACCAAGTATAATGGAGAAGGTGCTCATCCTCTGCCTTCCTTGAGCTTCT
1521 GGGTGATGCCAGGCCCAAGTCTTTGTGGCACCCAGCTCCATGCTTTGAATACTATGTGGCTGAATGAATTTTTAAAATCT
1601 CAAAGCAGTTAAACAGCAGGAAAGCCCATTAACTTCGTACTGAAAAAGCAACATACTGTGATGATACGGGATGACATCAT
1681 TTCAGGTTGGGCATACAAAAAAGTAAGGAAGCTAAACTAAGACTATACTCACCAGGCCATTTAGAAGTTTTAAATAATGC
1761 CTCCACTATTTTTTTTCTTAGACATAGCTTTTAATGGGGAAATGGAATTTTGTTATTAATACCCATTATATTCCTGTAAG
1841 TAAATGACTATTTTTCCCTTAACTCAGTGATTAGACAGGAAGGAAGACATTAGTGATTAGACAGGAGGGAAGATATTAGT
1921 GATTAGACAGCAGGGAAGATATTAGTGGTAAAGAGTGAATGATAGTAGTGAATATAAATGGGGCTGAGGAAACTTTAAGC
2001 ATAAAAGATTCCTGAGATGACTTTACAAGTCTGTACGAATCTGCCTTGACTGTATATTTCATACTGCCCAACAAAACAAT
2081 AAAAAACAATTTTAAATGCAAAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' accgACUUU-CUGG--UUUCUUGUu 5'
              ||||| ||:|  |:|||||| 
Target 5' ----TGAAATGATCTTAGAGAACAa 3'
 1 - 21 152.00 -13.80
2 
miRNA  3' accgaCUUUCUGGU-----UUCUUGUu 5'
               ||| | |::     ||||||| 
Target 5' acagaGAACGTCTGTTTTCAAGAACAa 3'
 33 - 59 145.00 -12.10
3 
miRNA  3' accGACUUUCUGGUUUC-UUGUu 5'
             |||||     |||| |||| 
Target 5' gtaCTGAA-----AAAGCAACAt 3'
 1637 - 1654 122.00 -6.70
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30452372 32 COSMIC
COSN31573840 38 COSMIC
COSN30543319 41 COSMIC
COSN30169698 59 COSMIC
COSN30122422 68 COSMIC
COSN30484854 77 COSMIC
COSN30163600 88 COSMIC
COSN14762636 102 COSMIC
COSN31593612 138 COSMIC
COSN31778397 516 COSMIC
COSN26567811 1006 COSMIC
COSN30542054 1198 COSMIC
COSN26688053 1402 COSMIC
COSN27360536 1463 COSMIC
COSN26507507 1493 COSMIC
COSN25765124 1505 COSMIC
COSN30538915 1509 COSMIC
COSN32065281 1636 COSMIC
COSN31587947 1667 COSMIC
COSN31482524 1670 COSMIC
COSN28696273 1692 COSMIC
COSN2117699 1750 COSMIC
COSN20101383 1810 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1244654724 3 dbSNP
rs2069684 6 dbSNP
rs1241043038 10 dbSNP
rs763773916 19 dbSNP
rs762756940 23 dbSNP
rs1283817742 27 dbSNP
rs1222175128 30 dbSNP
rs775317252 32 dbSNP
rs1411038367 33 dbSNP
rs1315766767 34 dbSNP
rs777253204 35 dbSNP
rs2069701 41 dbSNP
rs200098123 42 dbSNP
rs1431917632 43 dbSNP
rs769307910 46 dbSNP
rs1181294111 51 dbSNP
rs1317158672 51 dbSNP
rs572690258 57 dbSNP
rs958682642 64 dbSNP
rs1406474940 65 dbSNP
rs1343573955 67 dbSNP
rs1034676876 68 dbSNP
rs1002234443 69 dbSNP
rs1447584692 77 dbSNP
rs1282590043 78 dbSNP
rs1258272489 85 dbSNP
rs968441631 89 dbSNP
rs1022276477 90 dbSNP
rs1009674089 97 dbSNP
rs1234118607 98 dbSNP
rs2069685 102 dbSNP
rs2069702 106 dbSNP
rs1209015356 109 dbSNP
rs190180917 116 dbSNP
rs1182267834 124 dbSNP
rs1411231068 131 dbSNP
rs1411922939 132 dbSNP
rs2069686 135 dbSNP
rs1040345188 139 dbSNP
rs1425633089 142 dbSNP
rs1308416175 150 dbSNP
rs1332484827 153 dbSNP
rs372139148 154 dbSNP
rs1413932615 157 dbSNP
rs1400047555 159 dbSNP
rs757460096 162 dbSNP
rs1174221794 165 dbSNP
rs1356486659 167 dbSNP
rs759254142 182 dbSNP
rs551078614 191 dbSNP
rs1046672204 192 dbSNP
rs1348638938 203 dbSNP
rs1407330875 205 dbSNP
rs368607249 216 dbSNP
rs567479800 219 dbSNP
rs929735134 220 dbSNP
rs1344811894 221 dbSNP
rs1217803430 223 dbSNP
rs1276153310 225 dbSNP
rs1473373181 227 dbSNP
rs947790955 235 dbSNP
rs550301042 238 dbSNP
rs916989729 242 dbSNP
rs530516675 250 dbSNP
rs1205359798 267 dbSNP
rs1252089192 272 dbSNP
rs1187751434 280 dbSNP
rs1441028319 286 dbSNP
rs1250433642 294 dbSNP
rs992713069 298 dbSNP
rs1201559831 302 dbSNP
rs1247179150 303 dbSNP
rs753600254 308 dbSNP
rs927262691 309 dbSNP
rs979101098 312 dbSNP
rs1168153575 319 dbSNP
rs1368816262 321 dbSNP
rs989244760 327 dbSNP
rs1324829807 329 dbSNP
rs968600230 330 dbSNP
rs766140776 345 dbSNP
rs570072931 348 dbSNP
rs1022308877 354 dbSNP
rs1350525410 365 dbSNP
rs1266328383 366 dbSNP
rs1339498699 371 dbSNP
rs1224061122 373 dbSNP
rs1290575020 374 dbSNP
rs186008904 378 dbSNP
rs956812462 384 dbSNP
rs1196572408 399 dbSNP
rs181385728 404 dbSNP
rs998390675 412 dbSNP
rs2069687 415 dbSNP
rs1447078916 422 dbSNP
rs188551970 424 dbSNP
rs1426699892 425 dbSNP
rs760829267 433 dbSNP
rs772808862 441 dbSNP
rs1390035650 443 dbSNP
rs1404105270 455 dbSNP
rs2069703 467 dbSNP
rs888663492 469 dbSNP
rs1046748816 470 dbSNP
rs1318034262 471 dbSNP
rs573925844 478 dbSNP
rs1296497132 480 dbSNP
rs1458346023 481 dbSNP
rs929641843 488 dbSNP
rs895592683 489 dbSNP
rs1057270896 490 dbSNP
rs1246456128 491 dbSNP
rs1284279394 494 dbSNP
rs1027667151 496 dbSNP
rs1208012193 502 dbSNP
rs937077994 507 dbSNP
rs1471584415 515 dbSNP
rs994899810 516 dbSNP
rs897644207 521 dbSNP
rs927139463 544 dbSNP
rs1246486160 546 dbSNP
rs1446689354 547 dbSNP
rs1188431923 556 dbSNP
rs1446930419 557 dbSNP
rs961536 564 dbSNP
rs544747148 573 dbSNP
rs947296414 580 dbSNP
rs913145916 584 dbSNP
rs1390007023 587 dbSNP
rs988182741 589 dbSNP
rs1272830200 600 dbSNP
rs1457094773 606 dbSNP
rs1226851787 607 dbSNP
rs956675626 609 dbSNP
rs575678994 617 dbSNP
rs1397447120 621 dbSNP
rs774013674 627 dbSNP
rs1285738932 633 dbSNP
rs1339415763 646 dbSNP
rs977257954 648 dbSNP
rs964120584 651 dbSNP
rs1245240497 656 dbSNP
rs1364445093 657 dbSNP
rs1241948275 660 dbSNP
rs570686103 665 dbSNP
rs1018864510 675 dbSNP
rs1290212341 677 dbSNP
rs1295289494 681 dbSNP
rs1329763419 688 dbSNP
rs1227653087 689 dbSNP
rs768498680 696 dbSNP
rs1436700898 713 dbSNP
rs1201272442 717 dbSNP
rs947709592 723 dbSNP
rs1440831496 725 dbSNP
rs34421679 726 dbSNP
rs1184059336 730 dbSNP
rs1412720963 736 dbSNP
rs558749688 742 dbSNP
rs150370480 743 dbSNP
rs1025834078 747 dbSNP
rs759571869 748 dbSNP
rs1164263608 759 dbSNP
rs1475281417 767 dbSNP
rs1172842115 773 dbSNP
rs993822293 777 dbSNP
rs935098521 797 dbSNP
rs1393851365 799 dbSNP
rs1309332818 806 dbSNP
rs1350499330 820 dbSNP
rs1409171514 827 dbSNP
rs1388914331 829 dbSNP
rs1313792545 853 dbSNP
rs749097235 855 dbSNP
rs895499507 866 dbSNP
rs1255683982 869 dbSNP
rs2069688 877 dbSNP
rs141376959 882 dbSNP
rs1252665840 886 dbSNP
rs547273908 887 dbSNP
rs1180708203 889 dbSNP
rs1482740595 889 dbSNP
rs977626684 889 dbSNP
rs879564631 894 dbSNP
rs905578728 899 dbSNP
rs1252473650 906 dbSNP
rs1376214262 907 dbSNP
rs1464241013 914 dbSNP
rs1170040520 925 dbSNP
rs1370667064 926 dbSNP
rs1428501744 927 dbSNP
rs1306155373 933 dbSNP
rs536537852 946 dbSNP
rs947202991 947 dbSNP
rs567566627 960 dbSNP
rs1290844504 962 dbSNP
rs2069704 967 dbSNP
rs1230930841 973 dbSNP
rs1027635107 983 dbSNP
rs973446030 985 dbSNP
rs536782543 991 dbSNP
rs571332772 995 dbSNP
rs551159409 998 dbSNP
rs922594150 1004 dbSNP
rs976744367 1005 dbSNP
rs2069689 1006 dbSNP
rs911306878 1023 dbSNP
rs2069690 1031 dbSNP
rs1448426060 1039 dbSNP
rs1166184260 1045 dbSNP
rs952868630 1047 dbSNP
rs1025739366 1052 dbSNP
rs1458370197 1056 dbSNP
rs1292833064 1059 dbSNP
rs72777533 1065 dbSNP
rs79486762 1067 dbSNP
rs192155471 1071 dbSNP
rs1429557782 1072 dbSNP
rs1369128791 1075 dbSNP
rs758795409 1086 dbSNP
rs753309756 1089 dbSNP
rs547902182 1095 dbSNP
rs1226373243 1098 dbSNP
rs35656371 1099 dbSNP
rs1314955999 1109 dbSNP
rs1430961588 1111 dbSNP
rs1221515088 1115 dbSNP
rs1001203235 1119 dbSNP
rs905650002 1129 dbSNP
rs1395005963 1132 dbSNP
rs1209732124 1138 dbSNP
rs1247728074 1145 dbSNP
rs1448518409 1157 dbSNP
rs935067206 1168 dbSNP
rs1189606090 1169 dbSNP
rs1423860601 1172 dbSNP
rs531305010 1181 dbSNP
rs1041201082 1211 dbSNP
rs1458680018 1213 dbSNP
rs1181402973 1220 dbSNP
rs1482170978 1221 dbSNP
rs755333358 1225 dbSNP
rs1206943471 1228 dbSNP
rs543659800 1236 dbSNP
rs754257062 1246 dbSNP
rs145910089 1247 dbSNP
rs117606150 1254 dbSNP
rs1227785843 1255 dbSNP
rs1311274480 1256 dbSNP
rs891651103 1261 dbSNP
rs1346467166 1262 dbSNP
rs565383150 1264 dbSNP
rs1229493217 1273 dbSNP
rs1050680563 1282 dbSNP
rs1463795491 1289 dbSNP
rs1274882735 1293 dbSNP
rs1238824364 1294 dbSNP
rs760425620 1297 dbSNP
rs920587002 1314 dbSNP
rs1254687614 1325 dbSNP
rs1267489993 1328 dbSNP
rs933231332 1333 dbSNP
rs142445825 1339 dbSNP
rs1473539546 1342 dbSNP
rs1159751050 1343 dbSNP
rs1408862345 1347 dbSNP
rs923203812 1349 dbSNP
rs1310312594 1362 dbSNP
rs1178562569 1364 dbSNP
rs1359946687 1365 dbSNP
rs1410816167 1373 dbSNP
rs151054502 1387 dbSNP
rs749877946 1395 dbSNP
rs907929951 1396 dbSNP
rs562130982 1401 dbSNP
rs911324226 1402 dbSNP
rs984183531 1404 dbSNP
rs952775708 1406 dbSNP
rs1312415611 1412 dbSNP
rs1416621979 1418 dbSNP
rs1425994243 1419 dbSNP
rs1047494 1420 dbSNP
rs1182857626 1424 dbSNP
rs1471734647 1428 dbSNP
rs1250955310 1432 dbSNP
rs972843575 1435 dbSNP
rs536575075 1446 dbSNP
rs1425541602 1470 dbSNP
rs1012159767 1479 dbSNP
rs1171969604 1482 dbSNP
rs1483245274 1486 dbSNP
rs1236876042 1490 dbSNP
rs573977751 1491 dbSNP
rs1313831832 1509 dbSNP
rs960602931 1511 dbSNP
rs1439142952 1514 dbSNP
rs1227242584 1523 dbSNP
rs1367282417 1527 dbSNP
rs1326710511 1529 dbSNP
rs1277709448 1533 dbSNP
rs1343736531 1534 dbSNP
rs1035946148 1548 dbSNP
rs774288695 1556 dbSNP
rs557195493 1563 dbSNP
rs190680932 1570 dbSNP
rs1436008763 1575 dbSNP
rs1021273607 1577 dbSNP
rs866974005 1586 dbSNP
rs1229440624 1607 dbSNP
rs1247103804 1612 dbSNP
rs1477557750 1614 dbSNP
rs1192045331 1615 dbSNP
rs1392243309 1624 dbSNP
rs1450243279 1630 dbSNP
rs1011331469 1636 dbSNP
rs2069691 1637 dbSNP
rs1301414974 1647 dbSNP
rs185732573 1653 dbSNP
rs1360187240 1656 dbSNP
rs997355382 1665 dbSNP
rs901780728 1667 dbSNP
rs1414522729 1668 dbSNP
rs193230021 1672 dbSNP
rs1423424017 1673 dbSNP
rs1228594236 1674 dbSNP
rs762699223 1675 dbSNP
rs2069692 1677 dbSNP
rs565699692 1680 dbSNP
rs1230000067 1681 dbSNP
rs1290482934 1686 dbSNP
rs943252092 1687 dbSNP
rs2069693 1692 dbSNP
rs1249592500 1694 dbSNP
rs1465526439 1696 dbSNP
rs1207613613 1697 dbSNP
rs187480998 1702 dbSNP
rs1473799290 1704 dbSNP
rs940664740 1706 dbSNP
rs1413683327 1708 dbSNP
rs1460265207 1726 dbSNP
rs1048343742 1730 dbSNP
rs1463137056 1731 dbSNP
rs528861543 1736 dbSNP
rs1435406631 1751 dbSNP
rs878963131 1758 dbSNP
rs1269436720 1760 dbSNP
rs907892648 1765 dbSNP
rs1284779408 1769 dbSNP
rs1320686134 1771 dbSNP
rs982207691 1777 dbSNP
rs369823004 1779 dbSNP
rs116836657 1781 dbSNP
rs1329552572 1785 dbSNP
rs1208391012 1788 dbSNP
rs1259885760 1794 dbSNP
rs1444253056 1798 dbSNP
rs938846548 1802 dbSNP
rs991022670 1803 dbSNP
rs1236906531 1815 dbSNP
rs1474518588 1817 dbSNP
rs1380599297 1823 dbSNP
rs1297476508 1828 dbSNP
rs928912644 1829 dbSNP
rs1457026745 1832 dbSNP
rs1157697341 1836 dbSNP
rs139687205 1839 dbSNP
rs200663845 1840 dbSNP
rs2069694 1840 dbSNP
rs550055000 1843 dbSNP
rs1390964729 1844 dbSNP
rs1321246445 1845 dbSNP
rs1032232282 1856 dbSNP
rs533162021 1865 dbSNP
rs564118159 1869 dbSNP
rs970672954 1871 dbSNP
rs1350933822 1876 dbSNP
rs35717158 1880 dbSNP
rs1162501451 1884 dbSNP
rs1425314483 1894 dbSNP
rs999462171 1897 dbSNP
rs966347806 1900 dbSNP
rs1385832648 1903 dbSNP
rs1021306467 1913 dbSNP
rs989805445 1914 dbSNP
rs747299845 1917 dbSNP
rs1249367233 1918 dbSNP
rs1253153705 1924 dbSNP
rs1205138858 1930 dbSNP
rs773156893 1931 dbSNP
rs78370291 1935 dbSNP
rs1047529 1943 dbSNP
rs889572067 1944 dbSNP
rs182754102 1953 dbSNP
rs1374361052 1954 dbSNP
rs191769621 1955 dbSNP
rs1412192002 1963 dbSNP
rs899350679 1982 dbSNP
rs1351028098 1985 dbSNP
rs1390680009 1987 dbSNP
rs1322660120 1998 dbSNP
rs1047530 2008 dbSNP
rs371304065 2022 dbSNP
rs1007478901 2036 dbSNP
rs1345892510 2037 dbSNP
rs1207380942 2044 dbSNP
rs1046873750 2045 dbSNP
rs779408725 2046 dbSNP
rs1048417185 2047 dbSNP
rs1226866603 2061 dbSNP
rs949417559 2062 dbSNP
rs1394087151 2067 dbSNP
rs541873066 2072 dbSNP
rs1370569151 2080 dbSNP
rs1461438145 2084 dbSNP
rs931311626 2087 dbSNP
rs1392682908 2088 dbSNP
rs1387126541 2094 dbSNP
rs1298425921 2099 dbSNP
rs573669261 2100 dbSNP
rs1369061320 2101 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions BC-1
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM796037. RNA binding protein: AGO2. Condition:4-Thiouridine ...

- Gottwein E; Corcoran DL; Mukherjee N; et al., 2011, Cell host & microbe.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' accgacuuucugguUUCUUGUu 5'
                        ||||||| 
Target 5' ------------ucAAGAACAa 3'
 		1 - 10
Article - Gottwein E; Corcoran DL; Mukherjee N; et al.
- Cell host & microbe, 2011
Primary effusion lymphoma (PEL) is caused by Kaposi's sarcoma-associated herpesvirus (KSHV) and frequently also harbors Epstein-Barr virus (EBV). The expression of KSHV- and EBV-encoded microRNAs (miRNAs) in PELs suggests a role for these miRNAs in latency and lymphomagenesis. Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites. In addition to a known viral analog of cellular miR-155, we show that KSHV encodes a viral miRNA that mimics cellular miR-142-3p function. In summary, this study identifies an extensive list of KSHV miRNA targets, which are likely to influence viral replication and pathogenesis.
LinkOut: [PMID: 22100165]
CLIP-seq Support 1 for dataset GSM796037
Method / RBP PAR-CLIP / AGO2
Cell line / Condition BC-1 / 4-Thiouridine
Location of target site ENST00000296641.4 | 3UTR | UCAAGAACAACAUAAG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 22100165 / GSE32109
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
84 hsa-miR-4677-5p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT080553 PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1 2 2
MIRT089446 STAMBP STAM binding protein 2 2
MIRT135057 ADSS adenylosuccinate synthase 2 4
MIRT263519 RPS24 ribosomal protein S24 2 2
MIRT357966 GRPEL2 GrpE like 2, mitochondrial 2 2
MIRT384298 GOLT1B golgi transport 1B 2 2
MIRT407003 CEBPB CCAAT/enhancer binding protein beta 2 2
MIRT442312 UBE2Q1 ubiquitin conjugating enzyme E2 Q1 2 2
MIRT443782 ST13 ST13, Hsp70 interacting protein 2 2
MIRT446864 NBPF3 NBPF member 3 2 2
MIRT447642 RAB3GAP1 RAB3 GTPase activating protein catalytic subunit 1 2 2
MIRT448464 SLC45A4 solute carrier family 45 member 4 2 2
MIRT449117 XRRA1 X-ray radiation resistance associated 1 2 2
MIRT450240 TRIM66 tripartite motif containing 66 2 2
MIRT450265 F2RL2 coagulation factor II thrombin receptor like 2 2 2
MIRT450682 RPN2 ribophorin II 2 2
MIRT465594 TNRC6A trinucleotide repeat containing 6A 2 2
MIRT481118 AZIN1 antizyme inhibitor 1 2 4
MIRT497203 CDH7 cadherin 7 2 4
MIRT502954 CCNT2 cyclin T2 2 2
MIRT506337 NUP54 nucleoporin 54 2 4
MIRT509224 KIF14 kinesin family member 14 2 6
MIRT514595 NDUFA12 NADH:ubiquinone oxidoreductase subunit A12 2 4
MIRT515392 ARHGAP21 Rho GTPase activating protein 21 2 4
MIRT525555 MTRNR2L7 MT-RNR2-like 7 2 6
MIRT525604 MTRNR2L3 MT-RNR2-like 3 2 4
MIRT533249 VCAM1 vascular cell adhesion molecule 1 2 2
MIRT535778 MTRNR2L11 MT-RNR2-like 11 2 6
MIRT535799 MTRNR2L10 MT-RNR2-like 10 2 4
MIRT552784 YAF2 YY1 associated factor 2 2 2
MIRT556213 MB21D2 Mab-21 domain containing 2 2 2
MIRT558192 EIF2S1 eukaryotic translation initiation factor 2 subunit alpha 2 4
MIRT565809 SDCCAG3 serologically defined colon cancer antigen 3 2 2
MIRT566341 POLDIP2 DNA polymerase delta interacting protein 2 2 2
MIRT567792 DEK DEK proto-oncogene 2 2
MIRT572455 ZNF516 zinc finger protein 516 2 2
MIRT572582 HGFAC HGF activator 2 2
MIRT573357 PDE3A phosphodiesterase 3A 2 2
MIRT574649 LMAN2 lectin, mannose binding 2 2 2
MIRT608164 ERBB2 erb-b2 receptor tyrosine kinase 2 2 2
MIRT610690 FAM89A family with sequence similarity 89 member A 2 2
MIRT618457 TMCO1 transmembrane and coiled-coil domains 1 2 2
MIRT621924 SYAP1 synapse associated protein 1 2 4
MIRT622279 SH3TC2 SH3 domain and tetratricopeptide repeats 2 2 2
MIRT624610 B3GALT5 beta-1,3-galactosyltransferase 5 2 2
MIRT631040 TAS2R30 taste 2 receptor member 30 2 2
MIRT636153 TRPS1 transcriptional repressor GATA binding 1 2 2
MIRT638255 SIX1 SIX homeobox 1 2 2
MIRT638330 RCAN1 regulator of calcineurin 1 2 2
MIRT641621 KIAA1244 ARFGEF family member 3 3 3
MIRT644556 SPOP speckle type BTB/POZ protein 2 2
MIRT645900 LRIF1 ligand dependent nuclear receptor interacting factor 1 2 2
MIRT649115 SRD5A1 steroid 5 alpha-reductase 1 2 2
MIRT652244 TPI1 triosephosphate isomerase 1 2 2
MIRT657249 ICOSLG inducible T-cell costimulator ligand 2 2
MIRT659857 CAPRIN1 cell cycle associated protein 1 2 4
MIRT665369 XIAP X-linked inhibitor of apoptosis 2 2
MIRT669214 CAND1 cullin associated and neddylation dissociated 1 2 2
MIRT682579 CPA4 carboxypeptidase A4 2 2
MIRT698725 STX6 syntaxin 6 2 4
MIRT699788 SEC24A SEC24 homolog A, COPII coat complex component 2 2
MIRT700290 RABGEF1 RAB guanine nucleotide exchange factor 1 2 2
MIRT710374 LMBR1 limb development membrane protein 1 2 2
MIRT710407 YTHDC1 YTH domain containing 1 2 2
MIRT710569 TNPO1 transportin 1 2 2
MIRT711384 PLEKHG4B pleckstrin homology and RhoGEF domain containing G4B 2 2
MIRT712042 STYK1 serine/threonine/tyrosine kinase 1 2 2
MIRT712717 NCAPG2 non-SMC condensin II complex subunit G2 2 2
MIRT713288 ADAMTS20 ADAM metallopeptidase with thrombospondin type 1 motif 20 2 2
MIRT715649 USP6NL USP6 N-terminal like 2 2
MIRT716167 FAM71F2 family with sequence similarity 71 member F2 2 2
MIRT716756 TRABD2A TraB domain containing 2A 2 2
MIRT718209 TNRC6C trinucleotide repeat containing 6C 2 2
MIRT718361 SOX1 SRY-box 1 2 2
MIRT718806 SLC25A33 solute carrier family 25 member 33 2 2
MIRT719339 VGLL4 vestigial like family member 4 2 2
MIRT719671 SPDYE1 speedy/RINGO cell cycle regulator family member E1 2 2
MIRT720827 C1orf52 chromosome 1 open reading frame 52 2 2
MIRT722184 DNAJC9 DnaJ heat shock protein family (Hsp40) member C9 2 2
MIRT722398 BCAS2 BCAS2, pre-mRNA processing factor 2 2
MIRT723460 ST8SIA3 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3 2 2
MIRT724072 NCKAP1L NCK associated protein 1 like 2 2
MIRT724594 AP3B1 adaptor related protein complex 3 beta 1 subunit 2 2
MIRT725234 PDE1B phosphodiesterase 1B 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-4677 Doxorubicin 31703 NSC123127 approved resistant High Triple-Negative Breast Cancer cell line (MDA-MB-231, MDA-MB-468)
hsa-mir-4677 Ceritinib 57379345 NSC776422 approved resistant High Non-Small Cell Lung Cancer cell line (H3122, H2228)
hsa-mir-4677 Ceritinib 57379345 NSC776422 approved resistant cell line (H3122)
hsa-miR-4677-5p Gefitinib 123631 NSC715055 approved sensitive cell line (HCC827)
hsa-miR-4677-5p Gefitinib 123631 NSC715055 approved resistant cell line (HCC827)
hsa-miR-4677-5p Platinum 23939 sensitive tissue (non-small cell lung cancer)
hsa-miR-4677-5p Vemurafenib 42611257 NSC761431 approved resistant cell line (LM16)
hsa-miR-4677-5p Neoadjuvant chemotherapy resistant tissue (breast cancer)

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