pre-miRNA Information | |
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pre-miRNA | hsa-mir-7161 |
Genomic Coordinates | chr6: 158609707 - 158609790 |
Description | Homo sapiens miR-7161 stem-loop |
Comment | None |
RNA Secondary Structure |
Mature miRNA Information | |||||||||||||||||||||||||
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Mature miRNA | hsa-miR-7161-5p | ||||||||||||||||||||||||
Sequence | 1| UAAAGACUGUAGAGGCAACUGGU |23 | ||||||||||||||||||||||||
Evidence | Experimental | ||||||||||||||||||||||||
Experiments | Illumina | ||||||||||||||||||||||||
SNPs in miRNA |
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Putative Targets |
Gene Information | |||||||||||||||||||||
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Gene Symbol | ADH5 | ||||||||||||||||||||
Synonyms | ADH-3, ADHX, FALDH, FDH, GSH-FDH, GSNOR, HEL-S-60p | ||||||||||||||||||||
Description | alcohol dehydrogenase 5 (class III), chi polypeptide | ||||||||||||||||||||
Transcript | NM_000671 | ||||||||||||||||||||
Expression | |||||||||||||||||||||
Putative miRNA Targets on ADH5 | |||||||||||||||||||||
3'UTR of ADH5 (miRNA target sites are highlighted) |
>ADH5|NM_000671|3'UTR 1 TTCAAAAGAGAAAAATAATGTCCATCCTGTCGTGATGTGATAGGAGCAGCTTAACAGGCAGGGAGAAGCGCCTCCAACCT 81 CACAGCCTCGTAGAGCTTCACAGCTACTCCAGAAAATAGGGTTATGTGTGTCATTCATGAATCTCTATAATCAAGGACAA 161 GGATAATTCAGTCATGAACCTGTTTTCTGGATGCTCCTCCACATAAATAATTGCTAGTTTATTAAGGAATATTTTAACAT 241 AATAAAAGTAATTTCTACATTTGTGTGGAAATTGTCTTGTTTTATGCTGTCATCATTGTCACGGTTTGTCTGCCCATTAT 321 CTTCATTCTGCAAGGGAAAGGGAAAGGAAGCAGGGCAGTGGTGGGTGTCTGAAACCTCAGAAACATAACGTTGAACTTTT 401 AAGGGTCTCAGTCCCCGTTGATTAAAGAACAGATCCTAGCCATCAGTGACAAAGTTAATCAGGACCCAAGTCTGCTTCTG 481 TGATATTATCTTGAAGGGAGGTACTGTGCCTTGTTCATACCTGTACCCCAAATTCCTAGGATGGCATCTGCCCTTCAGGG 561 GGCACTAAAATGTATTATTGAAACAGCATTCTGGGCTTAAATAGGTGTATGTATGTGTTGGTTGTGACTGTACTATTTCT 641 AGTATAGTGAACTACATACTGAATATCCAAGTTCTCAGCACCTACTTTTGTCAAATCTTAACATTTTGCCACTTCGAGAT 721 CACATTGCCATTCCTCCCCTCCAGAGGTAACAATTATCCACAATTTGATGTTTATCATTCCTGTGTTGTTGTACTTTCAC 801 TGTGTATAACCTAAACCATCTACTCTTTAGTACTGTTTTATATATTTTTAAGCCTCATACTTGCTCATTCTACAGCTTTT 881 TTCACTCATTATTGTATAATTATATCTGAAGCTCTCGTTCATTAATTTTAGTCCTGTGTAGCAGAATTCAATTACGGGAA 961 CTACCATAATTTATCTGTTCTCCAGTTGAAGGCATGAAGTTGTTGCCAGTTTCTGTATTATAACACTGTAGTGGAACATT 1041 CTTCTGCATTGGGCTCACTGCGTGTTACCTAAGACGTATCACAGAATAAACACATTTAGCCTTATAGACATTGCCAAATT 1121 GCTCTTCAAAGTAAATGTGAGTTTTTGTGAATTACATGAGTATGGAATGGTGTTTTATTATGACTTTAGTTTGCATTTTC 1201 CTCAATTCTCGTTAAATCCTTCATTCTAATGGACATTTTATTGTGAAGAACCTGTTCATATCCTGTGCTCAACTTTGTAT 1281 TGAATTATTTTTCTCTGAATAATTTTTAGGAGTTCTTTTATTCTAGACATCAATCATTTGTCAGTTTTATATGTTGCAAA 1361 TATCTTCTAGTCTATCTTGTGACTTTTCTTTTTACTTTATGGTATTTTGTTGAATAAAGTTTTAATGTAGTCACATAAA Target sites
Provided by authors
Predicted by miRanda
DRVs
SNPs
DRVs & SNPs
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miRNA-target interactions (Predicted by miRanda) |
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DRVs in gene 3'UTRs | |||||||||||||||||||||
SNPs in gene 3'UTRs |
Experimental Support 1 for Functional miRNA-Target Interaction | |||||||
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miRNA:Target | ---- | ||||||
Validation Method |
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Conditions | BC-1 | ||||||
Location of target site | 3'UTR | ||||||
Tools used in this research | TargetScan , miRTarCLIP , Piranha | ||||||
Original Description (Extracted from the article) |
...
PAR-CLIP data was present in GSM796037. RNA binding protein: AGO2. Condition:4-Thiouridine
... - Gottwein E; Corcoran DL; Mukherjee N; et al., 2011, Cell host & microbe. |
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miRNA-target interactions (Provided by authors) |
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Article |
- Gottwein E; Corcoran DL; Mukherjee N; et al. - Cell host & microbe, 2011
Primary effusion lymphoma (PEL) is caused by Kaposi's sarcoma-associated herpesvirus (KSHV) and frequently also harbors Epstein-Barr virus (EBV). The expression of KSHV- and EBV-encoded microRNAs (miRNAs) in PELs suggests a role for these miRNAs in latency and lymphomagenesis. Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites. In addition to a known viral analog of cellular miR-155, we show that KSHV encodes a viral miRNA that mimics cellular miR-142-3p function. In summary, this study identifies an extensive list of KSHV miRNA targets, which are likely to influence viral replication and pathogenesis.
LinkOut: [PMID: 22100165]
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CLIP-seq Support 1 for dataset GSM796037 | |
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Method / RBP | PAR-CLIP / AGO2 |
Cell line / Condition | BC-1 / 4-Thiouridine |
Location of target site | ENST00000296412.8 | 3UTR | UCAAGUCUUUUUUUUUUUUUG |
Tools used in this analysis | TargetScan, miRTarCLIP, and Piranha |
Article / Accession Series | PMID: 22100165 / GSE32109 |
CLIP-seq Viewer | Link |
MiRNA-Target Expression Profile | |||||||
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MiRNA-Target Expression Profile (TCGA) | |||||||
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94 hsa-miR-7161-5p Target Genes:
Functional analysis:
ID | Target | Description | Validation methods | |||||||||
Strong evidence | Less strong evidence | |||||||||||
MIRT131193 | INCENP | inner centromere protein | 2 | 4 | ||||||||
MIRT318016 | CENPQ | centromere protein Q | 2 | 2 | ||||||||
MIRT405275 | ZNF678 | zinc finger protein 678 | 2 | 2 | ||||||||
MIRT442570 | CCDC59 | coiled-coil domain containing 59 | 2 | 2 | ||||||||
MIRT442611 | CRIPT | CXXC repeat containing interactor of PDZ3 domain | 2 | 2 | ||||||||
MIRT444013 | GOLGA8H | golgin A8 family member H | 2 | 2 | ||||||||
MIRT444024 | GOLGA8M | golgin A8 family member M | 2 | 2 | ||||||||
MIRT444339 | GOLGA6L4 | golgin A6 family-like 4 | 2 | 2 | ||||||||
MIRT444611 | GOLGA6L10 | golgin A6 family-like 10 | 2 | 2 | ||||||||
MIRT446342 | MAN1A2 | mannosidase alpha class 1A member 2 | 2 | 2 | ||||||||
MIRT446558 | GOLGA8J | golgin A8 family member J | 2 | 2 | ||||||||
MIRT447671 | PACSIN2 | protein kinase C and casein kinase substrate in neurons 2 | 2 | 2 | ||||||||
MIRT447975 | MSH6 | mutS homolog 6 | 2 | 2 | ||||||||
MIRT448895 | CNNM3 | cyclin and CBS domain divalent metal cation transport mediator 3 | 2 | 2 | ||||||||
MIRT448936 | CHD7 | chromodomain helicase DNA binding protein 7 | 2 | 2 | ||||||||
MIRT449414 | TRIM5 | tripartite motif containing 5 | 2 | 2 | ||||||||
MIRT450291 | ADH5 | alcohol dehydrogenase 5 (class III), chi polypeptide | 2 | 2 | ||||||||
MIRT454877 | PCNA | proliferating cell nuclear antigen | 2 | 4 | ||||||||
MIRT456615 | SFMBT2 | Scm like with four mbt domains 2 | 2 | 2 | ||||||||
MIRT462108 | TMEM214 | transmembrane protein 214 | 2 | 2 | ||||||||
MIRT471923 | NRAS | NRAS proto-oncogene, GTPase | 2 | 4 | ||||||||
MIRT474437 | KLHL21 | kelch like family member 21 | 2 | 2 | ||||||||
MIRT476600 | G3BP1 | G3BP stress granule assembly factor 1 | 2 | 2 | ||||||||
MIRT480573 | BZW1 | basic leucine zipper and W2 domains 1 | 2 | 2 | ||||||||
MIRT483890 | IL20RB | interleukin 20 receptor subunit beta | 2 | 6 | ||||||||
MIRT493363 | KIF5B | kinesin family member 5B | 2 | 2 | ||||||||
MIRT494934 | TMEM167A | transmembrane protein 167A | 2 | 2 | ||||||||
MIRT495915 | CLDN1 | claudin 1 | 2 | 2 | ||||||||
MIRT501574 | PLEKHF2 | pleckstrin homology and FYVE domain containing 2 | 2 | 4 | ||||||||
MIRT502193 | IGF1R | insulin like growth factor 1 receptor | 2 | 4 | ||||||||
MIRT502928 | CDC42SE1 | CDC42 small effector 1 | 2 | 4 | ||||||||
MIRT506393 | NUCKS1 | nuclear casein kinase and cyclin dependent kinase substrate 1 | 2 | 4 | ||||||||
MIRT506570 | MNX1 | motor neuron and pancreas homeobox 1 | 2 | 4 | ||||||||
MIRT509478 | GNL3L | G protein nucleolar 3 like | 2 | 6 | ||||||||
MIRT518537 | FLCN | folliculin | 2 | 6 | ||||||||
MIRT519577 | ZNFX1 | zinc finger NFX1-type containing 1 | 2 | 4 | ||||||||
MIRT524088 | DNAJC10 | DnaJ heat shock protein family (Hsp40) member C10 | 2 | 4 | ||||||||
MIRT524146 | LDHD | lactate dehydrogenase D | 2 | 4 | ||||||||
MIRT524659 | C1orf50 | chromosome 1 open reading frame 50 | 2 | 10 | ||||||||
MIRT526324 | UGT2A1 | UDP glucuronosyltransferase family 2 member A1 complex locus | 2 | 2 | ||||||||
MIRT526566 | UGT2A2 | UDP glucuronosyltransferase family 2 member A2 | 2 | 2 | ||||||||
MIRT526612 | ZNF780A | zinc finger protein 780A | 2 | 4 | ||||||||
MIRT526889 | PLEKHG2 | pleckstrin homology and RhoGEF domain containing G2 | 2 | 2 | ||||||||
MIRT527115 | ARHGAP15 | Rho GTPase activating protein 15 | 2 | 2 | ||||||||
MIRT528023 | ACOT9 | acyl-CoA thioesterase 9 | 2 | 2 | ||||||||
MIRT529589 | TMEM220 | transmembrane protein 220 | 2 | 2 | ||||||||
MIRT532797 | STYK1 | serine/threonine/tyrosine kinase 1 | 2 | 2 | ||||||||
MIRT537099 | GPC6 | glypican 6 | 2 | 2 | ||||||||
MIRT539070 | ATP6V1C1 | ATPase H+ transporting V1 subunit C1 | 2 | 2 | ||||||||
MIRT545495 | DAPK2 | death associated protein kinase 2 | 2 | 2 | ||||||||
MIRT545814 | ZNF608 | zinc finger protein 608 | 2 | 4 | ||||||||
MIRT553533 | TMEM185B | transmembrane protein 185B | 2 | 4 | ||||||||
MIRT557285 | HIST2H2BE | histone cluster 2 H2B family member e | 2 | 2 | ||||||||
MIRT559552 | ARGLU1 | arginine and glutamate rich 1 | 2 | 4 | ||||||||
MIRT561069 | EIF4A3 | eukaryotic translation initiation factor 4A3 | 2 | 2 | ||||||||
MIRT561710 | PTP4A1 | protein tyrosine phosphatase type IVA, member 1 | 2 | 2 | ||||||||
MIRT561995 | LRRC58 | leucine rich repeat containing 58 | 2 | 2 | ||||||||
MIRT565896 | NHS | NHS actin remodeling regulator | 2 | 2 | ||||||||
MIRT567333 | HMGB1 | high mobility group box 1 | 2 | 2 | ||||||||
MIRT568042 | CLDN12 | claudin 12 | 2 | 2 | ||||||||
MIRT568315 | BAG4 | BCL2 associated athanogene 4 | 2 | 2 | ||||||||
MIRT570677 | GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | 2 | 2 | ||||||||
MIRT571047 | YRDC | yrdC N6-threonylcarbamoyltransferase domain containing | 2 | 2 | ||||||||
MIRT571359 | SFT2D2 | SFT2 domain containing 2 | 2 | 2 | ||||||||
MIRT571935 | LCOR | ligand dependent nuclear receptor corepressor | 2 | 2 | ||||||||
MIRT572786 | ZNF277 | zinc finger protein 277 | 2 | 2 | ||||||||
MIRT573936 | CNTNAP2 | contactin associated protein like 2 | 2 | 2 | ||||||||
MIRT576962 | Anxa4 | annexin A4 | 2 | 3 | ||||||||
MIRT608297 | KATNAL1 | katanin catalytic subunit A1 like 1 | 2 | 2 | ||||||||
MIRT613342 | AFF1 | AF4/FMR2 family member 1 | 2 | 2 | ||||||||
MIRT613529 | ANAPC7 | anaphase promoting complex subunit 7 | 2 | 2 | ||||||||
MIRT614705 | TOR1AIP2 | torsin 1A interacting protein 2 | 2 | 2 | ||||||||
MIRT616658 | ORAI1 | ORAI calcium release-activated calcium modulator 1 | 2 | 2 | ||||||||
MIRT624731 | ANXA4 | annexin A4 | 2 | 3 | ||||||||
MIRT626525 | TSC1 | TSC complex subunit 1 | 2 | 2 | ||||||||
MIRT627647 | SCN1A | sodium voltage-gated channel alpha subunit 1 | 2 | 2 | ||||||||
MIRT637423 | EPB41L3 | erythrocyte membrane protein band 4.1 like 3 | 2 | 2 | ||||||||
MIRT641059 | TCP11L1 | t-complex 11 like 1 | 2 | 4 | ||||||||
MIRT645591 | SAR1A | secretion associated Ras related GTPase 1A | 2 | 2 | ||||||||
MIRT646455 | ZNF705A | zinc finger protein 705A | 2 | 2 | ||||||||
MIRT656454 | MAPK6 | mitogen-activated protein kinase 6 | 2 | 2 | ||||||||
MIRT676551 | TMPPE | transmembrane protein with metallophosphoesterase domain | 2 | 4 | ||||||||
MIRT682720 | KIAA1456 | KIAA1456 | 2 | 2 | ||||||||
MIRT698307 | TMEM2 | transmembrane protein 2 | 2 | 2 | ||||||||
MIRT701906 | MMGT1 | membrane magnesium transporter 1 | 2 | 2 | ||||||||
MIRT702228 | LONRF3 | LON peptidase N-terminal domain and ring finger 3 | 2 | 2 | ||||||||
MIRT708642 | UBE2W | ubiquitin conjugating enzyme E2 W | 2 | 2 | ||||||||
MIRT709326 | HMBOX1 | homeobox containing 1 | 2 | 2 | ||||||||
MIRT711400 | RANBP2 | RAN binding protein 2 | 2 | 2 | ||||||||
MIRT712130 | TGFBR2 | transforming growth factor beta receptor 2 | 2 | 2 | ||||||||
MIRT714226 | ARMC10 | armadillo repeat containing 10 | 2 | 2 | ||||||||
MIRT716914 | CACNB2 | calcium voltage-gated channel auxiliary subunit beta 2 | 2 | 2 | ||||||||
MIRT723060 | FGD6 | FYVE, RhoGEF and PH domain containing 6 | 2 | 2 | ||||||||
MIRT723846 | MN1 | MN1 proto-oncogene, transcriptional regulator | 2 | 2 |