miRTarBase - #MIRT450346


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pre-miRNA Information
pre-miRNA hsa-mir-8067   
Genomic Coordinates chr15: 62304658 - 62304734
Description Homo sapiens miR-8067 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-8067
Sequence 11| CCUAGAAACUGUAAACUUAGUC |32
Evidence Experimental
Experiments Illumina
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1439702395 3 dbSNP
rs973468045 19 dbSNP
rs1474855764 20 dbSNP
rs183845458 20 dbSNP
Putative Targets

Gene Information
Gene Symbol LHFPL3   
Synonyms LHFPL4
Description LHFPL tetraspan subfamily member 3
Transcript NM_199000   
Expression
Putative miRNA Targets on LHFPL3
3'UTR of LHFPL3
(miRNA target sites are highlighted)		 
>LHFPL3|NM_199000|3'UTR
   1 GCACAAAACAAATCGAATAACAGCTAAACAAATCGAATAACAGCTAAACGAATCGAATAACAGCTTTTGTACATCAACAT
  81 CAAGAAGGAATACGCCTGAGAGAGATCAGAGTATATAGATGAATATGAACAAGAATGGAACATTCACTTGTCAACGCACT
 161 TTCTAAATCTAGATCAGCAGAGATGGGAGTGATTTTCTGGAAAGAGATGTGATCATGGATTAAACACCAGCTCATTGGAA
 241 ACTCATTGGATGAGATCAGAAAACGTTCATGAAAAATCATATTCAGGAAATAAGGAAGAGGAATATAAATGCTCTAGAGT
 321 TAACATGTAAAATATATACGTACTGAGGTTTGTAAACTGTCCTTTTTAAATCAAACTGAAAACAAAAAGCTTTAACCTTT
 401 CAACAGAATTTTTAAAAAGGCAGTTAGTTCTAAATTATTCCTATCTCAATAGCCAAGAGGCTGATCAAGCGTCATTTATT
 481 GAGGAAGCATCTTAGAAAATGCCTCTGAATGTTTTCATAGGAGCCGTGACCTTTGGTTCTTCATCTCTACCATTCATTTA
 561 CTTCACTGTGTAATTAGTTACAACCACTCAGTTATTAAGAGACGTAACGCTTCAAACTTTTTACCAAGTCTGTGTTCTGT
 641 TTAATCTGTCCATACAAGTTATTACTGAGAAAGTGTTTATGCCATATACTATTACTCCATCAAGCTGTATATTACAGGAA
 721 GTACATCTTTACATCATAGGTTCCCAAGCAACATAGATTTCCCTATCTTTCAGGAAACAGCATCAAGGAACTCTGAAAAA
 801 TATAGAAAAAGTTCATTTTCACCTTGGAAGCTCACGTGTAATATTATAGGCTACTATCAAATAAACACTTTTTTTCTAAT
 881 TCTCCCTAGTATATGCATAGGAATTTAATATACTTTATAAATAAGTATCTAAAATGTCTCCTACTTTTTTCCTATTTCTT
 961 TGCCATACATGTTATCAGAAATCCATGTCTTCTATTTCCCTTACTGATGGGCACTCATTTTTATTTTTTTAAAAATCATT
1041 CCATTAAACATATTTCTAAATAATAGTAAGTGGTACTAACAAAATAAATAATAATTTAATAGCCTTAGAAATAAATGACT
1121 GTATACTTATACAGGTTGAAAAAAACTCGGTAGGAATAAGTTACCTTTTTGTTTACTAATGTTGGTTTCAAAAATACTCA
1201 GATTCATTTTAGTTGGCTGACATCTGGAAGTAGTTAACAACTAACCAGTGGACTTCAACAATCATTTGCTCCCAGGCTTC
1281 CCCCATCATCACCCTCACCACATATCCTGCTAATATCCAACAACAAACAAATATTTAATATTGAAATAGCCCATTGCCTG
1361 AGAATGAACACAAGCTAAAATACATGCAAGGGTACTTAATGGAAGCCAAACCATGTTCTATACCTAAGGAGAAAACATGG
1441 ACATGTAGAATGCTTTTATTCATGTATTCAAAATCAGAACAAATCAGTGTATATCACTAGAACATCAGATGGAGGATAAC
1521 ACAAGAAGTGATACAGATCAGGGTTCACTTCTCTTACCCTCTCTCTGTTAGGACCACATTCCTATTTTAGCCAAATGTTT
1601 CTGGTACGGGCCATCTTTTCACCATAAATGGCATTATGTTTCAAATGGCTAAAAGCATATTATGGGTATGCTCAAAGGAG
1681 TAAAACCCAATTCACAGAGATGTGGCTTTTCTAAAGAACCAAATTAAGGGAATACTTAGTATCTACAACTAAAGTATTAG
1761 TCATTCTGAGGATTATTTGTTGCTTTAAGTATTAGCTCCCTACTACATCCATAACACCCTACTTACTAAATTTAATTACA
1841 CACAACTTTTCAAGAATTCGTATTTTATTTGAAGGGAGGTACCTGTCTACTTTATCTACAATAAAAACAAAGGGTATTGG
1921 CTTTCTCTAATCCATGCAAACTACAAATTCCATCGGGAGTCCTACATCACTAACAGTGGTATGAACAAAACTAAGAAAGT
2001 ACTTCCTATCCACATGTGAATGTTTTAAAAAAGTTTTTGCCATAAAACCTAAGTGTAATTTAGCATACCACAGTGCTCTG
2081 AAGATGGGTCATTGACGATGTACCATTTGTATATAGGTAATACACATGTAAATCACTAATTGTTAATTAAATATAAGAAG
2161 TAGGTTTTTATCTTTTTAAAAAAAAAACAAAAAAGGTGACTCCCTTTCTCATTCTGTTCTGTTGTATTGCGTCCAAAAGT
2241 TGTGTGTAATTTTTTTAAGGTCCAAGAAATGTAAAGAAATTTGTTGGAATACCTGAATTTCTGTAAAAAAATAAAAATAA
2321 AAATAAGATTTTGTTACTTAAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' cuGAUUCAAAU--GU---CAAAGAUCc 5'
            || | ||||  ||   ||||||:| 
Target 5' tcCT-ATTTTAGCCAAATGTTTCTGGt 3'
 1580 - 1605 141.00 -6.40
2 
miRNA  3' cugAUUCAAAUGUCAAAGAUCc 5'
             |::|  |: | |||||:| 
Target 5' agaTGGGAGTG-ATTTTCTGGa 3'
 181 - 201 130.00 -7.80
3 
miRNA  3' cuGAUUCAAAUGUCAAAG-AUCc 5'
            ||:|    |:: |||| ||| 
Target 5' ctCTGA----ATGTTTTCATAGg 3'
 503 - 521 114.00 -5.70
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30136312 15 COSMIC
COSN31488230 16 COSMIC
COSN14249707 35 COSMIC
COSN31520447 35 COSMIC
COSN30136654 55 COSMIC
COSN20967418 58 COSMIC
COSN31511732 79 COSMIC
COSN31487428 85 COSMIC
COSN18722797 99 COSMIC
COSN2189876 126 COSMIC
COSN18722798 128 COSMIC
COSN30125293 131 COSMIC
COSN8515130 142 COSMIC
COSN31481807 150 COSMIC
COSN31606039 156 COSMIC
COSN31537496 174 COSMIC
COSN8515131 215 COSMIC
COSN31571656 245 COSMIC
COSN31577679 247 COSMIC
COSN31484148 300 COSMIC
COSN31529236 313 COSMIC
COSN31584610 412 COSMIC
COSN31549099 446 COSMIC
COSN20420683 526 COSMIC
COSN31482063 529 COSMIC
COSN31485508 556 COSMIC
COSN4930180 609 COSMIC
COSN31579261 767 COSMIC
COSN31590417 782 COSMIC
COSN29564208 908 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1390979397 3 dbSNP
rs1394785639 4 dbSNP
rs1167579494 5 dbSNP
rs758901902 6 dbSNP
rs1440334124 11 dbSNP
rs1323966141 14 dbSNP
rs368474937 15 dbSNP
rs773080259 16 dbSNP
rs1467122859 18 dbSNP
rs370934861 20 dbSNP
rs1180655073 21 dbSNP
rs762922734 22 dbSNP
rs1372288453 29 dbSNP
rs13307747 31 dbSNP
rs1388991867 31 dbSNP
rs778309233 31 dbSNP
rs1221825449 35 dbSNP
rs372641296 36 dbSNP
rs1335389816 38 dbSNP
rs1239801751 39 dbSNP
rs774085195 42 dbSNP
rs947761866 46 dbSNP
rs377263841 50 dbSNP
rs747338695 51 dbSNP
rs767023615 51 dbSNP
rs557833963 55 dbSNP
rs993127987 56 dbSNP
rs1256593106 60 dbSNP
rs1286542009 68 dbSNP
rs1053315508 69 dbSNP
rs577978343 71 dbSNP
rs1447985118 73 dbSNP
rs1264597722 74 dbSNP
rs1335338089 88 dbSNP
rs146703164 92 dbSNP
rs554288975 94 dbSNP
rs574268515 95 dbSNP
rs543271674 98 dbSNP
rs1381747484 101 dbSNP
rs775531217 103 dbSNP
rs74700377 104 dbSNP
rs764353262 119 dbSNP
rs1017222304 126 dbSNP
rs1240975974 131 dbSNP
rs1189537882 142 dbSNP
rs1442890952 145 dbSNP
rs1256975757 156 dbSNP
rs115201492 157 dbSNP
rs545723740 160 dbSNP
rs192129150 161 dbSNP
rs890095107 173 dbSNP
rs1472688593 185 dbSNP
rs532988136 207 dbSNP
rs1368229369 215 dbSNP
rs960548460 217 dbSNP
rs1450845448 219 dbSNP
rs992291069 227 dbSNP
rs1023394427 236 dbSNP
rs1397585029 237 dbSNP
rs1038992019 242 dbSNP
rs546366637 243 dbSNP
rs969421914 246 dbSNP
rs1298444331 247 dbSNP
rs560230596 249 dbSNP
rs979160446 265 dbSNP
rs527974383 266 dbSNP
rs994641821 271 dbSNP
rs770874923 272 dbSNP
rs1473111580 289 dbSNP
rs1027420761 291 dbSNP
rs1372394378 292 dbSNP
rs1192642838 294 dbSNP
rs1487359282 295 dbSNP
rs184677653 301 dbSNP
rs988958868 311 dbSNP
rs913379490 327 dbSNP
rs1004216872 337 dbSNP
rs1016084121 340 dbSNP
rs960106190 341 dbSNP
rs1410634821 342 dbSNP
rs934188989 345 dbSNP
rs1270114186 367 dbSNP
rs1217276662 369 dbSNP
rs1341838965 373 dbSNP
rs993220571 388 dbSNP
rs916195911 397 dbSNP
rs1403975305 415 dbSNP
rs1051582294 425 dbSNP
rs1325323333 431 dbSNP
rs1405731633 441 dbSNP
rs1395437244 447 dbSNP
rs549222350 451 dbSNP
rs1166095433 460 dbSNP
rs970271502 471 dbSNP
rs928533102 472 dbSNP
rs1194452586 473 dbSNP
rs926071780 480 dbSNP
rs1480255839 485 dbSNP
rs568729158 519 dbSNP
rs148849518 526 dbSNP
rs777696929 527 dbSNP
rs1483123404 547 dbSNP
rs1180913780 548 dbSNP
rs1272657377 548 dbSNP
rs1320558473 571 dbSNP
rs1278330121 576 dbSNP
rs1222336193 578 dbSNP
rs1365126451 583 dbSNP
rs1253728231 584 dbSNP
rs551658503 593 dbSNP
rs1276266060 599 dbSNP
rs1436674102 602 dbSNP
rs944414774 604 dbSNP
rs1189986443 605 dbSNP
rs755713467 605 dbSNP
rs567545006 609 dbSNP
rs534240132 610 dbSNP
rs898404375 615 dbSNP
rs994023384 616 dbSNP
rs1167310174 631 dbSNP
rs1372461862 633 dbSNP
rs1462619952 640 dbSNP
rs1302336979 644 dbSNP
rs1478454996 647 dbSNP
rs1400264613 648 dbSNP
rs1046981205 650 dbSNP
rs867060756 651 dbSNP
rs779651679 664 dbSNP
rs947997488 687 dbSNP
rs1048886470 689 dbSNP
rs1309942228 710 dbSNP
rs553952223 711 dbSNP
rs1005119244 713 dbSNP
rs1398027672 719 dbSNP
rs1280084263 731 dbSNP
rs1219474087 732 dbSNP
rs574154312 733 dbSNP
rs1349479445 743 dbSNP
rs1313106543 748 dbSNP
rs1364236865 750 dbSNP
rs1013423366 751 dbSNP
rs1015700127 753 dbSNP
rs1377631984 758 dbSNP
rs1023803141 766 dbSNP
rs1445644022 773 dbSNP
rs960388744 774 dbSNP
rs749155074 782 dbSNP
rs1415303574 783 dbSNP
rs1023366205 801 dbSNP
rs970302765 802 dbSNP
rs1253758444 803 dbSNP
rs978974681 821 dbSNP
rs1183552359 824 dbSNP
rs1484001699 824 dbSNP
rs926185488 831 dbSNP
rs536757146 832 dbSNP
rs1032033488 836 dbSNP
rs142530941 837 dbSNP
rs1449296203 840 dbSNP
rs1187220254 847 dbSNP
rs576711103 859 dbSNP
rs989032189 861 dbSNP
rs956232638 867 dbSNP
rs1429642718 868 dbSNP
rs1381225211 869 dbSNP
rs989368469 876 dbSNP
rs1175387809 882 dbSNP
rs911656710 889 dbSNP
rs1304699371 890 dbSNP
rs944429583 895 dbSNP
rs955687942 896 dbSNP
rs1296594772 899 dbSNP
rs545373272 912 dbSNP
rs377023325 913 dbSNP
rs749027052 914 dbSNP
rs911287871 919 dbSNP
rs921567074 928 dbSNP
rs942826573 945 dbSNP
rs1416586205 946 dbSNP
rs1387615508 952 dbSNP
rs1432719975 953 dbSNP
rs1322307129 955 dbSNP
rs930301361 958 dbSNP
rs1362506389 959 dbSNP
rs1049005503 964 dbSNP
rs56007018 972 dbSNP
rs57770518 973 dbSNP
rs1260321998 981 dbSNP
rs1298508584 991 dbSNP
rs919899476 995 dbSNP
rs1367188913 1002 dbSNP
rs929987110 1007 dbSNP
rs940565730 1009 dbSNP
rs577552305 1012 dbSNP
rs1290824041 1014 dbSNP
rs1056674347 1015 dbSNP
rs1046925758 1017 dbSNP
rs1323497188 1017 dbSNP
rs1213858254 1025 dbSNP
rs895921802 1031 dbSNP
rs1014717691 1032 dbSNP
rs1250313883 1048 dbSNP
rs1486456291 1052 dbSNP
rs1402136176 1054 dbSNP
rs1022979870 1055 dbSNP
rs905897416 1072 dbSNP
rs1293378282 1074 dbSNP
rs1456703313 1076 dbSNP
rs1423120992 1077 dbSNP
rs1435036586 1083 dbSNP
rs1166117382 1085 dbSNP
rs1477757306 1092 dbSNP
rs778509903 1098 dbSNP
rs1177409769 1102 dbSNP
rs1411430174 1104 dbSNP
rs145958309 1109 dbSNP
rs1195181880 1116 dbSNP
rs904923934 1123 dbSNP
rs1266223006 1124 dbSNP
rs1345604586 1128 dbSNP
rs1000194989 1135 dbSNP
rs1000595695 1139 dbSNP
rs1435633713 1139 dbSNP
rs58052615 1147 dbSNP
rs371220571 1149 dbSNP
rs374395270 1150 dbSNP
rs528923755 1157 dbSNP
rs1315966184 1159 dbSNP
rs1256284424 1160 dbSNP
rs1404957496 1163 dbSNP
rs1220543237 1164 dbSNP
rs1341426348 1168 dbSNP
rs1287172312 1171 dbSNP
rs1300862118 1184 dbSNP
rs1385241401 1189 dbSNP
rs1370218580 1190 dbSNP
rs1294436041 1199 dbSNP
rs1009236365 1202 dbSNP
rs1229885103 1211 dbSNP
rs771095524 1228 dbSNP
rs1020545515 1233 dbSNP
rs1317944877 1239 dbSNP
rs1196307498 1249 dbSNP
rs1434498220 1251 dbSNP
rs1267859749 1263 dbSNP
rs189148435 1276 dbSNP
rs1456443917 1277 dbSNP
rs1239922438 1282 dbSNP
rs987360756 1284 dbSNP
rs965830593 1287 dbSNP
rs79039929 1294 dbSNP
rs1200167627 1298 dbSNP
rs1251208119 1299 dbSNP
rs1314139578 1322 dbSNP
rs1302458379 1343 dbSNP
rs1446501310 1366 dbSNP
rs1375400017 1369 dbSNP
rs1333961842 1378 dbSNP
rs964574861 1381 dbSNP
rs1400906525 1390 dbSNP
rs1471713189 1390 dbSNP
rs1467298872 1391 dbSNP
rs1377843587 1392 dbSNP
rs1157891872 1394 dbSNP
rs1437610291 1397 dbSNP
rs1184661683 1412 dbSNP
rs1408416962 1415 dbSNP
rs1404612316 1422 dbSNP
rs1441722007 1425 dbSNP
rs974095610 1428 dbSNP
rs1198771908 1430 dbSNP
rs1484398020 1437 dbSNP
rs921681841 1444 dbSNP
rs1281287931 1446 dbSNP
rs920014296 1460 dbSNP
rs1351964222 1462 dbSNP
rs1351487416 1465 dbSNP
rs929978891 1468 dbSNP
rs1240452751 1474 dbSNP
rs1340365658 1477 dbSNP
rs1331709986 1483 dbSNP
rs531448805 1487 dbSNP
rs551378006 1488 dbSNP
rs571545728 1496 dbSNP
rs533865532 1500 dbSNP
rs1279826800 1505 dbSNP
rs547734486 1524 dbSNP
rs567671975 1544 dbSNP
rs1289748736 1545 dbSNP
rs536696399 1547 dbSNP
rs1045403823 1557 dbSNP
rs769741679 1558 dbSNP
rs936495502 1559 dbSNP
rs1425644681 1560 dbSNP
rs1288187407 1576 dbSNP
rs1258227105 1579 dbSNP
rs1216200336 1589 dbSNP
rs556740422 1598 dbSNP
rs10253341 1605 dbSNP
rs1273977175 1606 dbSNP
rs537148026 1609 dbSNP
rs1056305420 1611 dbSNP
rs896277008 1622 dbSNP
rs146199017 1623 dbSNP
rs1355577893 1626 dbSNP
rs1276968510 1631 dbSNP
rs1397806159 1648 dbSNP
rs17706864 1658 dbSNP
rs1298652187 1659 dbSNP
rs1472598712 1660 dbSNP
rs1388232688 1669 dbSNP
rs1179850862 1682 dbSNP
rs1044538760 1696 dbSNP
rs1458308394 1707 dbSNP
rs1418689849 1711 dbSNP
rs905929979 1721 dbSNP
rs191656562 1725 dbSNP
rs541378806 1752 dbSNP
rs1265599520 1754 dbSNP
rs1194102675 1763 dbSNP
rs1018951212 1766 dbSNP
rs1445135522 1767 dbSNP
rs553313382 1773 dbSNP
rs964206766 1780 dbSNP
rs1212177463 1792 dbSNP
rs567511632 1807 dbSNP
rs1032987300 1808 dbSNP
rs1431171483 1811 dbSNP
rs1342051484 1812 dbSNP
rs974250912 1812 dbSNP
rs573306958 1818 dbSNP
rs892050152 1819 dbSNP
rs951497103 1821 dbSNP
rs1399456209 1830 dbSNP
rs982730773 1839 dbSNP
rs542312202 1841 dbSNP
rs1010870842 1844 dbSNP
rs917903509 1860 dbSNP
rs548267161 1861 dbSNP
rs949426119 1865 dbSNP
rs1019184882 1875 dbSNP
rs966648534 1885 dbSNP
rs1201423902 1888 dbSNP
rs138891337 1897 dbSNP
rs1238089448 1903 dbSNP
rs1028727289 1913 dbSNP
rs936484220 1927 dbSNP
rs1273045150 1928 dbSNP
rs951768778 1935 dbSNP
rs984442036 1936 dbSNP
rs907512003 1938 dbSNP
rs1218299155 1941 dbSNP
rs1197562708 1954 dbSNP
rs1273828284 1955 dbSNP
rs940628156 1956 dbSNP
rs992520147 1958 dbSNP
rs535355460 1962 dbSNP
rs2430483 1971 dbSNP
rs1383572979 1974 dbSNP
rs1356376555 1978 dbSNP
rs1244723320 1980 dbSNP
rs1414162028 1981 dbSNP
rs545160160 1983 dbSNP
rs1044908598 1987 dbSNP
rs184798368 1997 dbSNP
rs1454991835 1998 dbSNP
rs1380001332 2024 dbSNP
rs1177343816 2029 dbSNP
rs141366167 2030 dbSNP
rs547377930 2031 dbSNP
rs1459440623 2035 dbSNP
rs1451265717 2044 dbSNP
rs936031190 2051 dbSNP
rs1208773720 2053 dbSNP
rs578245857 2055 dbSNP
rs1167943313 2064 dbSNP
rs1054467735 2067 dbSNP
rs1423898182 2069 dbSNP
rs1352760549 2073 dbSNP
rs891824836 2085 dbSNP
rs1412373353 2097 dbSNP
rs762288475 2100 dbSNP
rs772023737 2101 dbSNP
rs1007640742 2106 dbSNP
rs1041047075 2122 dbSNP
rs902078329 2124 dbSNP
rs767235545 2141 dbSNP
rs995621367 2143 dbSNP
rs1435524154 2166 dbSNP
rs1029095544 2167 dbSNP
rs951801215 2175 dbSNP
rs567659997 2176 dbSNP
rs1248212908 2178 dbSNP
rs139211927 2178 dbSNP
rs530155493 2178 dbSNP
rs550279684 2179 dbSNP
rs1238666019 2189 dbSNP
rs962056681 2189 dbSNP
rs1211184011 2194 dbSNP
rs991822916 2197 dbSNP
rs1344463296 2219 dbSNP
rs1487745614 2224 dbSNP
rs146983550 2225 dbSNP
rs372536670 2226 dbSNP
rs538782272 2232 dbSNP
rs1317504804 2245 dbSNP
rs1311938149 2260 dbSNP
rs980601309 2261 dbSNP
rs1226469801 2266 dbSNP
rs981217218 2271 dbSNP
rs1295146654 2273 dbSNP
rs1207813789 2274 dbSNP
rs926552663 2280 dbSNP
rs1340080338 2282 dbSNP
rs1296805180 2284 dbSNP
rs1455689016 2290 dbSNP
rs957970016 2291 dbSNP
rs989293827 2300 dbSNP
rs765789573 2304 dbSNP
rs189265042 2306 dbSNP
rs1193865962 2307 dbSNP
rs1245607642 2312 dbSNP
rs199900896 2313 dbSNP
rs936479250 2324 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions BC-1
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM796037. RNA binding protein: AGO2. Condition:4-Thiouridine ...

- Gottwein E; Corcoran DL; Mukherjee N; et al., 2011, Cell host & microbe.

Article - Gottwein E; Corcoran DL; Mukherjee N; et al.
- Cell host & microbe, 2011
Primary effusion lymphoma (PEL) is caused by Kaposi's sarcoma-associated herpesvirus (KSHV) and frequently also harbors Epstein-Barr virus (EBV). The expression of KSHV- and EBV-encoded microRNAs (miRNAs) in PELs suggests a role for these miRNAs in latency and lymphomagenesis. Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites. In addition to a known viral analog of cellular miR-155, we show that KSHV encodes a viral miRNA that mimics cellular miR-142-3p function. In summary, this study identifies an extensive list of KSHV miRNA targets, which are likely to influence viral replication and pathogenesis.
LinkOut: [PMID: 22100165]
CLIP-seq Support 1 for dataset GSM796037
Method / RBP PAR-CLIP / AGO2
Cell line / Condition BC-1 / 4-Thiouridine
Location of target site ENST00000287585.6 | 3UTR | UCAAGAAAUUUAUUCU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 22100165 / GSE32109
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
68 hsa-miR-8067 Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT084581 BCL2L11 BCL2 like 11 2 4
MIRT088215 NUP50 nucleoporin 50 2 2
MIRT092085 ABHD5 abhydrolase domain containing 5 2 2
MIRT135269 TMBIM6 transmembrane BAX inhibitor motif containing 6 2 8
MIRT175259 PSAT1 phosphoserine aminotransferase 1 2 6
MIRT182508 KLHL20 kelch like family member 20 2 2
MIRT286224 TMEM97 transmembrane protein 97 2 4
MIRT301718 TEF TEF, PAR bZIP transcription factor 2 2
MIRT329381 CCNG1 cyclin G1 2 2
MIRT362146 MTRNR2L6 MT-RNR2-like 6 2 4
MIRT366561 EIF2S3 eukaryotic translation initiation factor 2 subunit gamma 2 2
MIRT442002 NDUFV3 NADH:ubiquinone oxidoreductase subunit V3 2 2
MIRT442039 TRPV2 transient receptor potential cation channel subfamily V member 2 2 2
MIRT443045 HPS4 HPS4, biogenesis of lysosomal organelles complex 3 subunit 2 2 2
MIRT446861 SAMD9L sterile alpha motif domain containing 9 like 2 2
MIRT450346 LHFPL3 LHFPL tetraspan subfamily member 3 2 2
MIRT454306 ZNF134 zinc finger protein 134 2 2
MIRT481951 ANKRD11 ankyrin repeat domain 11 2 2
MIRT484816 ZNFX1 zinc finger NFX1-type containing 1 2 2
MIRT497596 EBAG9 estrogen receptor binding site associated, antigen, 9 2 2
MIRT498620 MTRNR2L10 MT-RNR2-like 10 2 12
MIRT501852 MTRNR2L8 MT-RNR2-like 8 2 15
MIRT502628 DDX3X DEAD-box helicase 3, X-linked 2 8
MIRT503298 GTF2A1 general transcription factor IIA subunit 1 2 6
MIRT506789 KLHL15 kelch like family member 15 2 6
MIRT515069 PLA2G2C phospholipase A2 group IIC 2 2
MIRT521334 RPRD2 regulation of nuclear pre-mRNA domain containing 2 2 2
MIRT523692 FHL2 four and a half LIM domains 2 2 4
MIRT524416 CNOT6L CCR4-NOT transcription complex subunit 6 like 2 4
MIRT525526 FSIP2 fibrous sheath interacting protein 2 2 2
MIRT525771 SOD2 superoxide dismutase 2 2 2
MIRT526262 CCDC169 coiled-coil domain containing 169 2 2
MIRT526545 MDM2 MDM2 proto-oncogene 2 2
MIRT527522 CD59 CD59 molecule (CD59 blood group) 2 2
MIRT530875 TRUB1 TruB pseudouridine synthase family member 1 2 4
MIRT532991 ZKSCAN8 zinc finger with KRAB and SCAN domains 8 2 2
MIRT535581 NUP35 nucleoporin 35 2 2
MIRT536922 HEPHL1 hephaestin like 1 2 2
MIRT540004 NT5DC3 5'-nucleotidase domain containing 3 2 2
MIRT540779 SCO1 SCO1, cytochrome c oxidase assembly protein 2 2
MIRT541006 ZNF136 zinc finger protein 136 2 2
MIRT542072 ASS1 argininosuccinate synthase 1 2 6
MIRT544103 IPMK inositol polyphosphate multikinase 2 2
MIRT547669 KPNA1 karyopherin subunit alpha 1 2 4
MIRT549914 MRPS30 mitochondrial ribosomal protein S30 2 2
MIRT551741 HIST1H2BD histone cluster 1 H2B family member d 2 2
MIRT556374 LUZP1 leucine zipper protein 1 2 2
MIRT557320 HIC2 HIC ZBTB transcriptional repressor 2 2 2
MIRT561442 TOB2 transducer of ERBB2, 2 2 2
MIRT563938 TAF7 TATA-box binding protein associated factor 7 2 2
MIRT622315 SEH1L SEH1 like nucleoporin 2 2
MIRT622334 SEC63 SEC63 homolog, protein translocation regulator 2 2
MIRT627928 KANSL1 KAT8 regulatory NSL complex subunit 1 2 2
MIRT636122 YPEL1 yippee like 1 2 2
MIRT644871 C2orf48 chromosome 2 open reading frame 48 2 2
MIRT645105 LANCL3 LanC like 3 2 2
MIRT650430 BBS9 Bardet-Biedl syndrome 9 2 2
MIRT653330 SMIM18 small integral membrane protein 18 2 2
MIRT658101 FOXN3 forkhead box N3 2 2
MIRT690032 CCDC90B coiled-coil domain containing 90B 2 2
MIRT697283 ZNF800 zinc finger protein 800 2 2
MIRT700266 RAP2B RAP2B, member of RAS oncogene family 2 2
MIRT700310 RABGEF1 RAB guanine nucleotide exchange factor 1 2 2
MIRT705431 ATP11A ATPase phospholipid transporting 11A 2 2
MIRT706193 MED24 mediator complex subunit 24 2 2
MIRT707928 PPP1R3D protein phosphatase 1 regulatory subunit 3D 2 2
MIRT716123 RPL24 ribosomal protein L24 2 2
MIRT720940 PPP1R3E protein phosphatase 1 regulatory subunit 3E 2 2

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