miRTarBase - #MIRT450849


—
pre-miRNA Information
pre-miRNA hsa-mir-4251   
Genomic Coordinates chr1: 3127975 - 3128035
Description Homo sapiens miR-4251 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-4251
Sequence 35| CCUGAGAAAAGGGCCAA |51
Evidence Experimental
Experiments SOLiD
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs529666453 6 dbSNP
rs761641851 13 dbSNP
rs1417009298 15 dbSNP
rs915117785 17 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol HTR2A   
Synonyms 5-HT2A, HTR2
Description 5-hydroxytryptamine receptor 2A
Transcript NM_000621   
Other Transcripts NM_001165947   
Expression
Putative miRNA Targets on HTR2A
3'UTR of HTR2A
(miRNA target sites are highlighted)		 
>HTR2A|NM_000621|3'UTR
   1 TAGGCTAGTTGCCGTGGCAACTGTGGAAGGCACACTGAGCAAGTTTTCACCTATCTGGAAAAAAAAAAATATGAGATTGG
  81 AAAAAATTAGACAAGTCTAGTGGAACCAACGATCATATCTGTATGCCTCATTTTATTCTGTCAATGAAAAGCGGGGTTCA
 161 ATGCTACAAAATGTGTGCTTGGAAAATGTTCTGACAGCATTTCAGCTGTGAGCTTTCTGATACTTATTTATAACATTGTA
 241 AATGATATGTCTTTAAAATGATTCACTTTTATTGTATAATTATGAAGCCCTAAGTAAATCTAAATTAACTTCTATTTTCA
 321 AGTGGAAACCTTGCTGCTATGCTGTTCATTGATGACATGGGATTGAGTTGGTTACCTATTGCTGTAAATAAAAATAGCTA
 401 TAAATAGTGAAAATTTTATTGAATATAATGGCCTCTTAAAAATTATCTTTAAAACTTACTATGGTATATATTTTGAAAGG
 481 AGAAAAAAAAAGCCACTAAGGTCAGTGTTATAAAATCTGTATTGCTAAGATAATTAAATGAAATACTTGACAACATTTTT
 561 CATTCCTGCTTTTTCATAGATACCATTTTGAAATATTCACAAGGTTGCTGGCATTTGCTGCATTTCAAGTTAATTCTCAG
 641 AAGTGAAAAAGACTTCAAATGTTATTCAATAACTATTGCTGCTTTCTCTTCTACTTCTTGTGCTTTACTCTGAATTTCCA
 721 GTGTGGTCTTGTTTAATATTTGTTCCTCTAGGTAAACTAGCAAAAGGATGATTTAACATTACCAAATGCCTTTCTAGCAA
 801 TTGCTTCTCTAAAACAGCACTATCGAGGTATTTGGTAACTTGCTGTGAAATGACTGCATCATGCATGCACTCTTTTGAGC
 881 AGTAAATGTATATTGATGTAACTGTGTCAGGATTGAGGATGAACTCAGGTTTCCGGCTACTGACAGTGGTAGAGTCCTAG
 961 GACATCTCTGTAAAAAGCAGGTGACTTTCCTATGACACTCATCAGGTAAACTGATGCTTTCAGATCCATCGGTTTATACT
1041 ATTTATTAAAACCATTCTGCTTGGTTCCACAATCATCTATTGAGTGTACATTTATGTGTGAAGCAAATTTCTAGATATGA
1121 GAAATATAAAAATAATTAAAACAAAATCCTTGCCTTCAAACGAAATGGCTCGGCCAGGCACGGAGGCTCGTGCATGTAAT
1201 CCTAGCACTTTGGGAGGCTGAGATGGGAGGATCACTTGAGGCCAAGAGTTTGAGACCAACCTGGGTAACAAAGTGAGACC
1281 TCCCTGTCTCTACAAAAAAAATCAAAAAATTATCTGATCCTTGTGGCACACAACTGTGGTCCCAGCTACAGGGGAGGCTG
1361 AGACGCAAGGATCACTTGAGCCCAGAAGCTCAAGGCTGCAGTGAGCCAAGTTCACACCACTGCCATTTCCTCCTGGGCAA
1441 CAGAGTGAGACCCTATCACAAAAAAAAAGAAAGAAAAAAAGAAAATGACTAAACTGAAATGGTCTTAGTCAAAAAATATA
1521 TACAGACTTATTTTTAGAATCATTTCAACTTATTTCCTTCTTACCTGGTTCAGAAACAAGTTTGTTTCAACTGTGAGAGT
1601 AGTTTTAAAAATAAGTTTTCCTGATTGGTTACCAATAAACACCAAACAAATAAAGGAGGGGGAAAATATCACTTGAGGCT
1681 TAACATTGCAATTAATTTAGAAATACGCACCTCAATCTCAAGCCAGTTTATAACTACCATAGTTTTGAGCAAAATTTTTC
1761 TTCTATTTCTCCAAAAACTCACTCATTTCAGTATTACTCATTGACACTGGGCTCCCTAATAGAAAAGCAGATATTATAAT
1841 ATTTCATTGAAATGGTTACTAAAGAGAAAAAGAGATTAACAACAGTTAATCCACCTTGATATTATAACACTCAAGGTTAA
1921 ATTGCATGTTGTTATTAGAATCAATGTTATATATATGATTACAATGCTGAAGCATTTCTATTGAATGAGAAATAGTGTTT
2001 GCCCTAAACCTTTGGGAAAAAAATACAGATTTGAAAACTAAAGAATGTGGGAAGTGTCATTGTGTAATTTGGAAATGCAT
2081 AAAATTCTCATTATGTCCTCATAGATATGTTGAAAGATGGTTCACTGTTTCAAAGATAGAATGTATAATATGCTGCTAGT
2161 ACCAAGGCTGCATTTGAACTGAACTACTCCTTATGATATACCATACTAACTGATGAAAATATAAATGTTAAAATGTCTCC
2241 ACTCTAATGTATTTTGCCTTCACTTGTAACTCTGCACATTTCATTATATATTAGGGAAAAGATTACAGATTCTACCCCCA
2321 TATACTCAATCTTGATCAGAATGTACATTAATGTTGCCTGATAGATGTCTTTTGACTACCTATATATTACAAATGTGTAT
2401 GTGTTTTTTTCTTCCATAAGTATCTATTCAAGTGTATACTGTATAGGCAAATGTGTAGCTGTATATATGTACAGACATGT
2481 TCTCATGCACTTTATTCAATATTTATATATTTATATGGACGAAAAGCAAGTCAATGAAAACACTCAGTATATACACATGT
2561 GTGCATGTTTGTATCATGTTTATTTAAATGTGAATTCATGTTCTAATATTTCTATGACCTTCCATTGCTGCAAAGCAGAT
2641 TAAAGTGTAACAAAAATATCAGCTCTTTAAATAAACTGGAAATTAATCTAATTTTGTGGAAGAACTTTAAGACAAGTCTA
2721 TGAGGATGGCGAAAACAATGGTCCACATATATAGTTTCTTGATCCTAAATAAAATGGTACCTTTGGGCCCTTTGTTTAGT
2801 CTGGCAATTTTCTGACTACTATGGCTTTTTAAACAGACTCACACCTAAGTGAAACACAGTTGTCAAATGATTTATGGATC
2881 TGTGATTAAAGGATTCACTTTTAATGAATACTATTAAAACGGAGTAACAAACCTTGCTCTACTTTAAGTTGAATGATAGA
2961 TTCCTCTATATTCAAAAAAAAGCAATTAACTGCCATAATTAGGGAAAACTGTTTAAAGCATACTGCATTTACTTGGCCAC
3041 AGCGCCATCTCATGGTAATTTTTTAAAGTGCTACCGTAGCCAAATTGAACTAAGTCACTGTACTGCTTTCAGCAAAGGGT
3121 GCTCCTCCCATTTGTGCATCAATGAGACATATTTATAAAGTGCTAAATTATTCTGTGCCATATGTAACAAATACAGTGAA
3201 GATTATTTTATGAACTTATTTTAATCAAGGCGATGCTAAAAGTTTTCAAGAAAGGATAAATAACTGTAAATAAAGTAGAC
3281 TCAAAAATGAATGAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' aaccgggaaAAGAGUCc 5'
                   ||||||| 
Target 5' tcaagttaaTTCTCAGa 3'
 625 - 641 140.00 -7.40
2 
miRNA  3' aacCGGGAAAAGAGUcc 5'
             | | | ||||||  
Target 5' acaGACATGTTCTCAtg 3'
 2471 - 2487 126.00 -6.80
3 
miRNA  3' aaccGGGA--AAAGAGUcc 5'
              :|||  |||:|||  
Target 5' tcatTCCTGCTTTTTCAta 3'
 560 - 578 115.00 -5.30
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30162967 2 COSMIC
COSN26979474 12 COSMIC
COSN8593285 14 COSMIC
COSN31496368 30 COSMIC
COSN31495584 32 COSMIC
COSN30508187 42 COSMIC
COSN20110691 58 COSMIC
COSN1158956 59 COSMIC
COSN30462711 61 COSMIC
COSN30167767 67 COSMIC
COSN30165255 75 COSMIC
COSN31543196 76 COSMIC
COSN30475354 80 COSMIC
COSN18737549 121 COSMIC
COSN31574478 191 COSMIC
COSN30159846 193 COSMIC
COSN154960 339 COSMIC
COSN32058466 419 COSMIC
COSN31517185 517 COSMIC
COSN31540115 678 COSMIC
COSN25976318 906 COSMIC
COSN23002589 1275 COSMIC
COSN29748572 1293 COSMIC
COSN24046205 1496 COSMIC
COSN16203111 1588 COSMIC
COSN24992627 1660 COSMIC
COSN30615962 1955 COSMIC
COSN30715666 2016 COSMIC
COSN30756496 2017 COSMIC
COSN27143211 2281 COSMIC
COSN24428255 2430 COSMIC
COSN1158955 2466 COSMIC
COSN6230295 2468 COSMIC
COSN1158954 2530 COSMIC
COSN29151172 2591 COSMIC
COSN22101345 2864 COSMIC
COSN30551414 2974 COSMIC
COSN17276184 3059 COSMIC
COSN30707367 3111 COSMIC
COSN5338784 3174 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1372407863 5 dbSNP
rs1226277397 12 dbSNP
rs756869129 13 dbSNP
rs140353574 14 dbSNP
rs1365983498 17 dbSNP
rs1424188475 18 dbSNP
rs778337563 21 dbSNP
rs201890406 22 dbSNP
rs370829834 26 dbSNP
rs1340753055 27 dbSNP
rs200080463 28 dbSNP
rs1416933556 29 dbSNP
rs755032042 30 dbSNP
rs765043077 32 dbSNP
rs1401862845 40 dbSNP
rs901502180 49 dbSNP
rs79674499 57 dbSNP
rs397947348 59 dbSNP
rs1359182406 68 dbSNP
rs1040701743 69 dbSNP
rs1289126607 70 dbSNP
rs58145637 70 dbSNP
rs938876144 70 dbSNP
rs1426615604 72 dbSNP
rs886289270 72 dbSNP
rs370237853 79 dbSNP
rs1443771714 87 dbSNP
rs1161502476 90 dbSNP
rs1374418807 91 dbSNP
rs930448030 101 dbSNP
rs927402319 109 dbSNP
rs200127940 111 dbSNP
rs906206495 112 dbSNP
rs1167782898 115 dbSNP
rs1448350244 116 dbSNP
rs3125 121 dbSNP
rs1318305639 123 dbSNP
rs564086363 124 dbSNP
rs1259570229 127 dbSNP
rs1484607722 135 dbSNP
rs916320431 144 dbSNP
rs1195450692 151 dbSNP
rs544505018 152 dbSNP
rs931160436 153 dbSNP
rs1362348429 154 dbSNP
rs778402317 160 dbSNP
rs1196139872 161 dbSNP
rs878965083 167 dbSNP
rs1470989641 173 dbSNP
rs1481116602 175 dbSNP
rs1337528345 177 dbSNP
rs972634511 178 dbSNP
rs575310515 181 dbSNP
rs1300211491 182 dbSNP
rs1374525301 192 dbSNP
rs752780609 205 dbSNP
rs1305842530 209 dbSNP
rs1341561255 213 dbSNP
rs1304205555 219 dbSNP
rs1019589889 222 dbSNP
rs1237196537 223 dbSNP
rs1460780547 226 dbSNP
rs985457631 227 dbSNP
rs781353528 232 dbSNP
rs1329832636 242 dbSNP
rs1021703340 244 dbSNP
rs1480836245 246 dbSNP
rs1456950151 248 dbSNP
rs1301081999 249 dbSNP
rs1176466828 265 dbSNP
rs1012196644 272 dbSNP
rs891972428 274 dbSNP
rs1029192862 277 dbSNP
rs1395463217 282 dbSNP
rs995905943 299 dbSNP
rs901507668 307 dbSNP
rs1031810028 310 dbSNP
rs1468644749 313 dbSNP
rs867975165 319 dbSNP
rs1173168590 321 dbSNP
rs1355696606 322 dbSNP
rs1003145724 325 dbSNP
rs1296855792 348 dbSNP
rs1348204042 365 dbSNP
rs1406418284 373 dbSNP
rs1283306652 374 dbSNP
rs1398999478 381 dbSNP
rs1322228013 389 dbSNP
rs3803189 402 dbSNP
rs551111749 404 dbSNP
rs751860795 407 dbSNP
rs1174943611 416 dbSNP
rs1203521245 421 dbSNP
rs529560726 426 dbSNP
rs151187004 431 dbSNP
rs1376988944 432 dbSNP
rs547303666 444 dbSNP
rs894929982 447 dbSNP
rs1200429199 458 dbSNP
rs1048147958 460 dbSNP
rs1479494591 468 dbSNP
rs931025541 473 dbSNP
rs918435247 475 dbSNP
rs1420661180 479 dbSNP
rs1248082786 480 dbSNP
rs1203307854 481 dbSNP
rs1482833826 482 dbSNP
rs528125789 483 dbSNP
rs1281190998 484 dbSNP
rs905664046 490 dbSNP
rs1044878654 492 dbSNP
rs1168723259 492 dbSNP
rs1367866600 492 dbSNP
rs1344543433 509 dbSNP
rs972514603 510 dbSNP
rs1433648702 517 dbSNP
rs758284718 519 dbSNP
rs1343572147 521 dbSNP
rs142119527 523 dbSNP
rs1213940615 547 dbSNP
rs988802498 548 dbSNP
rs542732421 556 dbSNP
rs1361332653 561 dbSNP
rs1223036104 563 dbSNP
rs1240312192 578 dbSNP
rs1489934107 579 dbSNP
rs985896789 599 dbSNP
rs754837096 600 dbSNP
rs1217998481 617 dbSNP
rs1242804110 620 dbSNP
rs17069218 622 dbSNP
rs978974243 634 dbSNP
rs753789790 644 dbSNP
rs1286809616 666 dbSNP
rs1163399332 672 dbSNP
rs182944696 680 dbSNP
rs1022004359 681 dbSNP
rs1355675306 684 dbSNP
rs1028451455 692 dbSNP
rs1319664937 699 dbSNP
rs190839539 703 dbSNP
rs542054192 708 dbSNP
rs1295307320 710 dbSNP
rs1384978446 720 dbSNP
rs148625875 723 dbSNP
rs552886187 726 dbSNP
rs965792307 742 dbSNP
rs77274377 746 dbSNP
rs1225703778 751 dbSNP
rs1199135255 770 dbSNP
rs1284967135 772 dbSNP
rs1004573817 775 dbSNP
rs1003029566 778 dbSNP
rs1206973009 779 dbSNP
rs1245491432 790 dbSNP
rs75604221 795 dbSNP
rs1183328040 800 dbSNP
rs1159088784 801 dbSNP
rs1455239708 804 dbSNP
rs1023214751 818 dbSNP
rs557694225 819 dbSNP
rs776309770 821 dbSNP
rs894819801 825 dbSNP
rs1399601557 828 dbSNP
rs994719735 838 dbSNP
rs766444467 840 dbSNP
rs1361889395 842 dbSNP
rs539553503 844 dbSNP
rs905711864 856 dbSNP
rs1181160970 864 dbSNP
rs1453322458 866 dbSNP
rs1335778448 870 dbSNP
rs1338493477 871 dbSNP
rs760491424 877 dbSNP
rs995237387 881 dbSNP
rs1258479509 884 dbSNP
rs1280349296 886 dbSNP
rs1190243855 890 dbSNP
rs1440780840 895 dbSNP
rs1350299417 902 dbSNP
rs1226617083 907 dbSNP
rs896889559 909 dbSNP
rs1255494776 918 dbSNP
rs569285914 924 dbSNP
rs1036851852 927 dbSNP
rs1324838494 928 dbSNP
rs557169652 934 dbSNP
rs1254423827 935 dbSNP
rs575813702 947 dbSNP
rs1439913757 949 dbSNP
rs574217885 955 dbSNP
rs943865185 960 dbSNP
rs1014491709 967 dbSNP
rs912507917 968 dbSNP
rs1156262576 969 dbSNP
rs1430813916 970 dbSNP
rs1049668227 972 dbSNP
rs932526639 979 dbSNP
rs1353435149 989 dbSNP
rs1053130512 1001 dbSNP
rs914591173 1006 dbSNP
rs934694804 1015 dbSNP
rs1329346384 1023 dbSNP
rs1335357039 1028 dbSNP
rs143950250 1030 dbSNP
rs149887481 1031 dbSNP
rs547343985 1036 dbSNP
rs528765432 1038 dbSNP
rs1346237947 1040 dbSNP
rs932895209 1041 dbSNP
rs1294752416 1060 dbSNP
rs924682901 1068 dbSNP
rs1339388877 1072 dbSNP
rs1342145893 1075 dbSNP
rs1196716117 1087 dbSNP
rs976973504 1089 dbSNP
rs981646447 1092 dbSNP
rs1386343876 1098 dbSNP
rs775248657 1102 dbSNP
rs911681185 1103 dbSNP
rs1461772079 1114 dbSNP
rs983166852 1119 dbSNP
rs1167396930 1121 dbSNP
rs1471908379 1124 dbSNP
rs950368602 1126 dbSNP
rs1463490893 1127 dbSNP
rs1193970438 1132 dbSNP
rs1395525391 1133 dbSNP
rs1427991935 1143 dbSNP
rs1305181009 1151 dbSNP
rs1027302440 1153 dbSNP
rs771186172 1161 dbSNP
rs1299334335 1162 dbSNP
rs1023521815 1171 dbSNP
rs970029056 1172 dbSNP
rs1013183731 1181 dbSNP
rs534230386 1182 dbSNP
rs139431449 1189 dbSNP
rs552156442 1190 dbSNP
rs995118037 1194 dbSNP
rs1264681190 1202 dbSNP
rs1430176576 1204 dbSNP
rs187932958 1206 dbSNP
rs1193817084 1211 dbSNP
rs563437455 1214 dbSNP
rs895630931 1216 dbSNP
rs1007892193 1224 dbSNP
rs890968531 1228 dbSNP
rs541548326 1232 dbSNP
rs1049997556 1234 dbSNP
rs1366393138 1239 dbSNP
rs147331468 1240 dbSNP
rs767274319 1249 dbSNP
rs773640840 1260 dbSNP
rs1270327649 1261 dbSNP
rs1291807064 1263 dbSNP
rs1387250440 1266 dbSNP
rs1383201166 1269 dbSNP
rs914461239 1271 dbSNP
rs1228966827 1274 dbSNP
rs770314789 1283 dbSNP
rs1316209313 1288 dbSNP
rs998856562 1292 dbSNP
rs1243632068 1294 dbSNP
rs182787658 1301 dbSNP
rs904551260 1302 dbSNP
rs1319821159 1311 dbSNP
rs1181154764 1318 dbSNP
rs1205262501 1322 dbSNP
rs1247315478 1324 dbSNP
rs1054494613 1331 dbSNP
rs1463517617 1339 dbSNP
rs1185153561 1342 dbSNP
rs1043005791 1350 dbSNP
rs1441482884 1361 dbSNP
rs371900593 1364 dbSNP
rs190609503 1365 dbSNP
rs1454357228 1366 dbSNP
rs924568727 1381 dbSNP
rs781223602 1388 dbSNP
rs1455076257 1395 dbSNP
rs1403865461 1401 dbSNP
rs1413335859 1403 dbSNP
rs1337741271 1418 dbSNP
rs1041689913 1420 dbSNP
rs971445197 1432 dbSNP
rs1394725481 1440 dbSNP
rs367742222 1445 dbSNP
rs944229006 1451 dbSNP
rs186085133 1454 dbSNP
rs1476436805 1456 dbSNP
rs1388341367 1457 dbSNP
rs1188513694 1458 dbSNP
rs1455053879 1459 dbSNP
rs1205497771 1460 dbSNP
rs908672922 1464 dbSNP
rs138503618 1469 dbSNP
rs1491010517 1469 dbSNP
rs540338469 1469 dbSNP
rs983219760 1470 dbSNP
rs950421244 1476 dbSNP
rs56054677 1480 dbSNP
rs1177786404 1481 dbSNP
rs1359156610 1481 dbSNP
rs564141222 1482 dbSNP
rs1273273339 1485 dbSNP
rs1197121356 1486 dbSNP
rs768170546 1500 dbSNP
rs546222352 1501 dbSNP
rs1022916782 1502 dbSNP
rs181176511 1508 dbSNP
rs73473860 1510 dbSNP
rs1373071945 1515 dbSNP
rs1311575260 1516 dbSNP
rs535554765 1518 dbSNP
rs998908857 1519 dbSNP
rs575106493 1520 dbSNP
rs1015179268 1525 dbSNP
rs538548214 1531 dbSNP
rs1354834637 1541 dbSNP
rs9595552 1542 dbSNP
rs35865007 1547 dbSNP
rs996895285 1573 dbSNP
rs1481453802 1577 dbSNP
rs890846437 1584 dbSNP
rs371981599 1590 dbSNP
rs1425040962 1596 dbSNP
rs775917336 1597 dbSNP
rs1368826062 1599 dbSNP
rs1168004638 1602 dbSNP
rs1429919124 1603 dbSNP
rs770290069 1624 dbSNP
rs997075978 1628 dbSNP
rs893093574 1635 dbSNP
rs1368378109 1636 dbSNP
rs1406221713 1639 dbSNP
rs535340943 1641 dbSNP
rs1427861168 1652 dbSNP
rs1274961586 1655 dbSNP
rs1366762028 1657 dbSNP
rs758075452 1661 dbSNP
rs944265432 1667 dbSNP
rs1297374811 1670 dbSNP
rs1054377755 1687 dbSNP
rs934532335 1694 dbSNP
rs903198579 1695 dbSNP
rs1045741028 1706 dbSNP
rs1490912774 1707 dbSNP
rs1223259668 1708 dbSNP
rs950187780 1709 dbSNP
rs1477290848 1715 dbSNP
rs1188804727 1717 dbSNP
rs915965840 1735 dbSNP
rs1449226978 1748 dbSNP
rs1167154687 1751 dbSNP
rs571209902 1754 dbSNP
rs1387896692 1755 dbSNP
rs1047289978 1761 dbSNP
rs1477912263 1763 dbSNP
rs867555402 1765 dbSNP
rs1233759094 1767 dbSNP
rs7324942 1771 dbSNP
rs1290550174 1778 dbSNP
rs930802372 1780 dbSNP
rs1227360756 1784 dbSNP
rs1295165821 1790 dbSNP
rs765229080 1791 dbSNP
rs1361792575 1792 dbSNP
rs920721413 1799 dbSNP
rs1289151335 1803 dbSNP
rs150864801 1807 dbSNP
rs962239396 1809 dbSNP
rs1243176061 1811 dbSNP
rs1015231606 1818 dbSNP
rs1210968594 1827 dbSNP
rs1187014879 1832 dbSNP
rs1245370871 1833 dbSNP
rs986411796 1839 dbSNP
rs1350051525 1843 dbSNP
rs915522455 1860 dbSNP
rs1163479854 1876 dbSNP
rs746222657 1882 dbSNP
rs1412701327 1883 dbSNP
rs879542127 1884 dbSNP
rs757284317 1886 dbSNP
rs1160714723 1888 dbSNP
rs1389233807 1891 dbSNP
rs375708588 1894 dbSNP
rs1318225454 1896 dbSNP
rs548290059 1901 dbSNP
rs1281034472 1903 dbSNP
rs892968970 1904 dbSNP
rs1225509455 1910 dbSNP
rs1268875664 1915 dbSNP
rs1032818945 1919 dbSNP
rs529721605 1921 dbSNP
rs1207394198 1924 dbSNP
rs1265616087 1926 dbSNP
rs998792037 1928 dbSNP
rs7325801 1937 dbSNP
rs1187348655 1952 dbSNP
rs1236505640 1956 dbSNP
rs968518269 1957 dbSNP
rs1178377657 1959 dbSNP
rs1045793000 1962 dbSNP
rs950083370 1963 dbSNP
rs1456574862 1968 dbSNP
rs1156847118 1979 dbSNP
rs532074960 1980 dbSNP
rs1414802243 1997 dbSNP
rs997301212 2002 dbSNP
rs1056283377 2009 dbSNP
rs899851298 2013 dbSNP
rs7324218 2016 dbSNP
rs1444658081 2022 dbSNP
rs532170461 2031 dbSNP
rs1008217560 2036 dbSNP
rs972181903 2040 dbSNP
rs760300386 2051 dbSNP
rs564874009 2053 dbSNP
rs912138689 2055 dbSNP
rs887381628 2065 dbSNP
rs1346378274 2068 dbSNP
rs868575916 2074 dbSNP
rs191481876 2080 dbSNP
rs955218390 2081 dbSNP
rs1027955851 2086 dbSNP
rs1440281393 2089 dbSNP
rs1047341917 2091 dbSNP
rs975583528 2100 dbSNP
rs1409221598 2102 dbSNP
rs1161793391 2103 dbSNP
rs1471437065 2108 dbSNP
rs1471970250 2109 dbSNP
rs978020130 2119 dbSNP
rs957122580 2121 dbSNP
rs7324017 2127 dbSNP
rs575622041 2136 dbSNP
rs967320448 2146 dbSNP
rs1024224026 2151 dbSNP
rs1014132161 2154 dbSNP
rs1399805518 2159 dbSNP
rs1395535850 2168 dbSNP
rs7323693 2169 dbSNP
rs763185752 2187 dbSNP
rs7325200 2193 dbSNP
rs1285312437 2194 dbSNP
rs770190084 2199 dbSNP
rs899237574 2200 dbSNP
rs1036517027 2203 dbSNP
rs1233173220 2206 dbSNP
rs748620067 2214 dbSNP
rs912021860 2226 dbSNP
rs1052455913 2229 dbSNP
rs1301131818 2235 dbSNP
rs1274883394 2237 dbSNP
rs7325168 2241 dbSNP
rs1346290556 2243 dbSNP
rs1202357053 2244 dbSNP
rs1323054181 2251 dbSNP
rs1452046358 2261 dbSNP
rs1198075977 2264 dbSNP
rs1375916986 2265 dbSNP
rs1451075534 2267 dbSNP
rs1169032905 2274 dbSNP
rs1389741542 2275 dbSNP
rs1428092134 2300 dbSNP
rs968529137 2303 dbSNP
rs1455980809 2312 dbSNP
rs117222059 2315 dbSNP
rs1165226297 2317 dbSNP
rs747130005 2318 dbSNP
rs77955866 2319 dbSNP
rs780076744 2322 dbSNP
rs957139677 2325 dbSNP
rs1297361399 2326 dbSNP
rs1340958129 2326 dbSNP
rs1225734555 2329 dbSNP
rs1266912509 2332 dbSNP
rs925687601 2334 dbSNP
rs1356422070 2343 dbSNP
rs7323441 2344 dbSNP
rs1265150487 2346 dbSNP
rs1466227129 2349 dbSNP
rs1486187674 2350 dbSNP
rs745611455 2351 dbSNP
rs1447812980 2353 dbSNP
rs778830071 2362 dbSNP
rs1167167622 2365 dbSNP
rs1024106498 2368 dbSNP
rs200776063 2372 dbSNP
rs1161575566 2375 dbSNP
rs1391418063 2384 dbSNP
rs1206675199 2389 dbSNP
rs1014598342 2399 dbSNP
rs1464290585 2404 dbSNP
rs757159451 2412 dbSNP
rs1454969962 2416 dbSNP
rs1314409442 2418 dbSNP
rs1340741251 2422 dbSNP
rs753822756 2426 dbSNP
rs78215834 2428 dbSNP
rs1263195664 2431 dbSNP
rs1331064695 2437 dbSNP
rs1234171638 2440 dbSNP
rs994835133 2444 dbSNP
rs186026796 2454 dbSNP
rs1025911330 2455 dbSNP
rs1323703382 2477 dbSNP
rs181685677 2479 dbSNP
rs1227802969 2485 dbSNP
rs1423491948 2501 dbSNP
rs564123995 2510 dbSNP
rs1045611571 2515 dbSNP
rs1004890158 2520 dbSNP
rs1012403517 2521 dbSNP
rs542118167 2526 dbSNP
rs890638040 2527 dbSNP
rs1388408284 2534 dbSNP
rs1326960271 2536 dbSNP
rs1387160878 2539 dbSNP
rs1467874097 2547 dbSNP
rs1051916541 2554 dbSNP
rs371208348 2556 dbSNP
rs1459168488 2559 dbSNP
rs569651540 2559 dbSNP
rs73473857 2560 dbSNP
rs938382634 2561 dbSNP
rs376652404 2568 dbSNP
rs924244668 2577 dbSNP
rs1256389229 2578 dbSNP
rs1483015080 2583 dbSNP
rs1391427917 2593 dbSNP
rs1041636738 2602 dbSNP
rs947278896 2614 dbSNP
rs914484587 2619 dbSNP
rs767027670 2637 dbSNP
rs1039813789 2647 dbSNP
rs1181604482 2648 dbSNP
rs1253442386 2656 dbSNP
rs975678551 2658 dbSNP
rs1489625704 2666 dbSNP
rs373388872 2680 dbSNP
rs1177171002 2682 dbSNP
rs935648358 2684 dbSNP
rs925567963 2686 dbSNP
rs912673159 2694 dbSNP
rs977175445 2715 dbSNP
rs1372072712 2725 dbSNP
rs565483580 2726 dbSNP
rs547077793 2729 dbSNP
rs1221039259 2730 dbSNP
rs1342996198 2731 dbSNP
rs1299872599 2738 dbSNP
rs986849321 2739 dbSNP
rs967089762 2742 dbSNP
rs917086943 2749 dbSNP
rs1311376766 2754 dbSNP
rs951364715 2756 dbSNP
rs1277003232 2760 dbSNP
rs1483523586 2761 dbSNP
rs1204467164 2766 dbSNP
rs1025625352 2775 dbSNP
rs1226894711 2777 dbSNP
rs1365074050 2778 dbSNP
rs1425152106 2780 dbSNP
rs143283300 2783 dbSNP
rs1170918007 2786 dbSNP
rs958901265 2788 dbSNP
rs963318667 2790 dbSNP
rs1023870741 2794 dbSNP
rs759201672 2801 dbSNP
rs1306808560 2804 dbSNP
rs973254575 2821 dbSNP
rs564715461 2822 dbSNP
rs1012866183 2825 dbSNP
rs1294017536 2839 dbSNP
rs1438069659 2839 dbSNP
rs896642608 2840 dbSNP
rs963356290 2844 dbSNP
rs1343071485 2859 dbSNP
rs751250647 2875 dbSNP
rs1014850408 2877 dbSNP
rs1004942507 2883 dbSNP
rs1271233987 2891 dbSNP
rs1371911512 2893 dbSNP
rs1222460752 2908 dbSNP
rs1246602898 2909 dbSNP
rs1002537486 2920 dbSNP
rs1166145014 2921 dbSNP
rs890528796 2928 dbSNP
rs142795977 2932 dbSNP
rs902871955 2934 dbSNP
rs1030946861 2941 dbSNP
rs996352825 2952 dbSNP
rs900793038 2960 dbSNP
rs1406568938 2961 dbSNP
rs1054040603 2966 dbSNP
rs914513407 2967 dbSNP
rs1459825379 2970 dbSNP
rs936871693 2982 dbSNP
rs942536217 2982 dbSNP
rs1434173445 2986 dbSNP
rs531470747 2995 dbSNP
rs563709921 2997 dbSNP
rs1190866644 3008 dbSNP
rs1483487584 3019 dbSNP
rs1041380515 3020 dbSNP
rs541905869 3021 dbSNP
rs1289266962 3026 dbSNP
rs1333253497 3028 dbSNP
rs1211129250 3038 dbSNP
rs916992633 3043 dbSNP
rs993104259 3052 dbSNP
rs1464718522 3059 dbSNP
rs937187326 3060 dbSNP
rs1048952 3065 dbSNP
rs762219821 3074 dbSNP
rs930014473 3075 dbSNP
rs879894746 3076 dbSNP
rs1181879154 3079 dbSNP
rs974091527 3082 dbSNP
rs1473979634 3086 dbSNP
rs973308250 3089 dbSNP
rs1389354234 3098 dbSNP
rs1203096801 3102 dbSNP
rs963242471 3106 dbSNP
rs1257110723 3110 dbSNP
rs1361060944 3114 dbSNP
rs1024341027 3119 dbSNP
rs777069918 3130 dbSNP
rs769214879 3135 dbSNP
rs114038752 3138 dbSNP
rs1230373985 3143 dbSNP
rs954995059 3144 dbSNP
rs961161919 3149 dbSNP
rs1030415573 3153 dbSNP
rs189458400 3159 dbSNP
rs996622862 3173 dbSNP
rs1391660293 3175 dbSNP
rs1203707636 3180 dbSNP
rs900674898 3196 dbSNP
rs1281188536 3199 dbSNP
rs1035123423 3201 dbSNP
rs999636202 3206 dbSNP
rs1305712686 3208 dbSNP
rs1032485327 3213 dbSNP
rs1001136892 3214 dbSNP
rs544149183 3215 dbSNP
rs1412566048 3227 dbSNP
rs541518530 3231 dbSNP
rs138191230 3232 dbSNP
rs558852850 3234 dbSNP
rs61948307 3236 dbSNP
rs1376901342 3241 dbSNP
rs1159535094 3242 dbSNP
rs892770886 3246 dbSNP
rs145579064 3250 dbSNP
rs1373926871 3256 dbSNP
rs1411694954 3275 dbSNP
rs942610940 3285 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions BC-1
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM796037. RNA binding protein: AGO2. Condition:4-Thiouridine ...

- Gottwein E; Corcoran DL; Mukherjee N; et al., 2011, Cell host & microbe.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' aaccgggaaAAGAGUCc 5'
                   ||||||| 
Target 5' ucaaguuaaUUCUCAG- 3'
 		1 - 16
Article - Gottwein E; Corcoran DL; Mukherjee N; et al.
- Cell host & microbe, 2011
Primary effusion lymphoma (PEL) is caused by Kaposi's sarcoma-associated herpesvirus (KSHV) and frequently also harbors Epstein-Barr virus (EBV). The expression of KSHV- and EBV-encoded microRNAs (miRNAs) in PELs suggests a role for these miRNAs in latency and lymphomagenesis. Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites. In addition to a known viral analog of cellular miR-155, we show that KSHV encodes a viral miRNA that mimics cellular miR-142-3p function. In summary, this study identifies an extensive list of KSHV miRNA targets, which are likely to influence viral replication and pathogenesis.
LinkOut: [PMID: 22100165]
CLIP-seq Support 1 for dataset GSM796037
Method / RBP PAR-CLIP / AGO2
Cell line / Condition BC-1 / 4-Thiouridine
Location of target site ENST00000378688.4 | 3UTR | UCAAGUUAAUUCUCAG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 22100165 / GSE32109
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
98 hsa-miR-4251 Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT056156 OTUD1 OTU deubiquitinase 1 2 2
MIRT080004 MYL12B myosin light chain 12B 2 2
MIRT080407 ONECUT2 one cut homeobox 2 2 2
MIRT081901 KCTD15 potassium channel tetramerization domain containing 15 2 2
MIRT090342 SEC61A1 Sec61 translocon alpha 1 subunit 2 8
MIRT096824 ZSWIM6 zinc finger SWIM-type containing 6 2 4
MIRT140185 CHAC1 ChaC glutathione specific gamma-glutamylcyclotransferase 1 2 2
MIRT149716 LDLR low density lipoprotein receptor 2 6
MIRT205293 STK11IP serine/threonine kinase 11 interacting protein 2 2
MIRT213265 REST RE1 silencing transcription factor 2 6
MIRT254069 BACH1 BTB domain and CNC homolog 1 2 2
MIRT256251 ANKRD33B ankyrin repeat domain 33B 2 2
MIRT264966 TMEM136 transmembrane protein 136 2 2
MIRT267496 FEN1 flap structure-specific endonuclease 1 2 2
MIRT285077 MIER1 MIER1 transcriptional regulator 2 2
MIRT296167 NCOA3 nuclear receptor coactivator 3 2 2
MIRT316073 ABRACL ABRA C-terminal like 2 2
MIRT360286 HIST1H3E histone cluster 1 H3 family member e 2 2
MIRT364793 PRRC2B proline rich coiled-coil 2B 2 2
MIRT443277 TSPAN15 tetraspanin 15 2 2
MIRT443453 CLIC5 chloride intracellular channel 5 2 2
MIRT445938 KLHL32 kelch like family member 32 2 2
MIRT448012 HLA-DOA major histocompatibility complex, class II, DO alpha 2 2
MIRT448382 TP53INP1 tumor protein p53 inducible nuclear protein 1 2 4
MIRT448499 RYBP RING1 and YY1 binding protein 2 2
MIRT449896 C11orf34 placenta expressed transcript 1 1 2
MIRT450457 ZDHHC2 zinc finger DHHC-type containing 2 2 2
MIRT450849 HTR2A 5-hydroxytryptamine receptor 2A 2 2
MIRT453774 NUCB1 nucleobindin 1 2 10
MIRT464399 URM1 ubiquitin related modifier 1 2 2
MIRT465008 TUBB2A tubulin beta 2A class IIa 2 8
MIRT465145 TSC22D2 TSC22 domain family member 2 2 2
MIRT467799 SLC2A14 solute carrier family 2 member 14 2 2
MIRT472597 NACC1 nucleus accumbens associated 1 2 2
MIRT477969 DPM2 dolichyl-phosphate mannosyltransferase subunit 2, regulatory 2 2
MIRT486586 ZNF619 zinc finger protein 619 2 2
MIRT487739 MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 2 4
MIRT492529 PTMA prothymosin, alpha 2 6
MIRT496845 KCNIP2 potassium voltage-gated channel interacting protein 2 2 2
MIRT499064 CTBP1 C-terminal binding protein 1 2 4
MIRT502046 LAMTOR1 late endosomal/lysosomal adaptor, MAPK and MTOR activator 1 2 6
MIRT503907 ZSCAN25 zinc finger and SCAN domain containing 25 2 2
MIRT506776 KLHL15 kelch like family member 15 2 4
MIRT510003 UCP1 uncoupling protein 1 2 6
MIRT513040 BRIX1 BRX1, biogenesis of ribosomes 2 2
MIRT513174 MOAP1 modulator of apoptosis 1 2 6
MIRT517592 ZNF579 zinc finger protein 579 2 4
MIRT521825 POLR1D RNA polymerase I subunit D 2 2
MIRT530663 TRIM56 tripartite motif containing 56 2 2
MIRT531718 TARS threonyl-tRNA synthetase 2 2
MIRT535154 PLEKHG5 pleckstrin homology and RhoGEF domain containing G5 2 2
MIRT536385 LEFTY1 left-right determination factor 1 2 2
MIRT543847 APIP APAF1 interacting protein 2 2
MIRT546973 PRKAB2 protein kinase AMP-activated non-catalytic subunit beta 2 2 2
MIRT548667 CSRNP3 cysteine and serine rich nuclear protein 3 2 2
MIRT548799 CLIP4 CAP-Gly domain containing linker protein family member 4 2 4
MIRT549610 TMEM101 transmembrane protein 101 2 2
MIRT549716 NUP37 nucleoporin 37 2 4
MIRT549873 ZNF260 zinc finger protein 260 2 2
MIRT555383 PPP1CC protein phosphatase 1 catalytic subunit gamma 2 2
MIRT566976 LBR lamin B receptor 2 2
MIRT568052 CHSY1 chondroitin sulfate synthase 1 2 2
MIRT570970 TMBIM4 transmembrane BAX inhibitor motif containing 4 2 2
MIRT571174 ZNF85 zinc finger protein 85 2 2
MIRT571364 ZNF45 zinc finger protein 45 2 2
MIRT572309 LSM4 LSM4 homolog, U6 small nuclear RNA and mRNA degradation associated 2 2
MIRT572493 BTN2A2 butyrophilin subfamily 2 member A2 2 2
MIRT606783 KIAA0040 KIAA0040 2 5
MIRT607952 NFAM1 NFAT activating protein with ITAM motif 1 2 10
MIRT609978 HERPUD2 HERPUD family member 2 2 2
MIRT610069 CD300E CD300e molecule 2 2
MIRT610118 IL17REL interleukin 17 receptor E like 2 2
MIRT610151 PRMT8 protein arginine methyltransferase 8 2 4
MIRT611075 ZNF621 zinc finger protein 621 2 2
MIRT612011 COX17 COX17, cytochrome c oxidase copper chaperone 2 2
MIRT617901 PTCHD3 patched domain containing 3 2 2
MIRT618052 MRVI1 murine retrovirus integration site 1 homolog 2 2
MIRT619526 ZNF74 zinc finger protein 74 2 2
MIRT624276 CRISPLD2 cysteine rich secretory protein LCCL domain containing 2 2 2
MIRT625357 MGLL monoglyceride lipase 2 2
MIRT626756 NDUFA9 NADH:ubiquinone oxidoreductase subunit A9 2 2
MIRT628851 FAM151B family with sequence similarity 151 member B 2 2
MIRT630458 GMPS guanine monophosphate synthase 2 2
MIRT634536 MRPS17 mitochondrial ribosomal protein S17 2 2
MIRT638806 DCTN3 dynactin subunit 3 2 2
MIRT647607 TMTC2 transmembrane and tetratricopeptide repeat containing 2 2 2
MIRT650885 PPP1R15A protein phosphatase 1 regulatory subunit 15A 2 2
MIRT653507 SLC43A2 solute carrier family 43 member 2 2 2
MIRT658608 ENTPD5 ectonucleoside triphosphate diphosphohydrolase 5 2 2
MIRT666345 SKAP2 src kinase associated phosphoprotein 2 2 2
MIRT693743 ACACA acetyl-CoA carboxylase alpha 2 2
MIRT704049 EDEM3 ER degradation enhancing alpha-mannosidase like protein 3 2 2
MIRT709789 CYBRD1 cytochrome b reductase 1 2 2
MIRT711837 AMOTL2 angiomotin like 2 2 2
MIRT711875 VASP vasodilator stimulated phosphoprotein 2 2
MIRT717349 RAB40A RAB40A, member RAS oncogene family 2 2
MIRT717746 MYLK myosin light chain kinase 2 2
MIRT725398 LRIG2 leucine rich repeats and immunoglobulin like domains 2 2 2
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-4 Dexamethasone approved 5743 Microarray primary rat thymocytes 20847043 2010 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-4251 Imatinib 5291 NSC743414 approved sensitive High Gastrointestinal Stromal Tumor cell line (882R-NC, 882R-OE, 882R-KD)
hsa-miR-4251 Doxorubicin 31703 NSC123127 approved resistant High Triple-Negative Breast Cancer cell line (MDA-MB-231, MDA-MB-468)
hsa-mir-4251 Paclitaxel 36314 NSC125973 approved sensitive cell line (A2780)
hsa-miR-4251 Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-4251 Gemcitabine 60750 NSC613327 approved resistant cell line (PANC-1) (100 ng/ml)

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