miRTarBase - #MIRT451488


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pre-miRNA Information
pre-miRNA hsa-mir-3678   
Genomic Coordinates chr17: 75406069 - 75406162
Description Homo sapiens miR-3678 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-3678-3p
Sequence 69| CUGCAGAGUUUGUACGGACCGG |90
Evidence Experimental
Experiments Illumina
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs988363493 1 dbSNP
rs753118178 5 dbSNP
rs1424776090 14 dbSNP
rs1475188526 15 dbSNP
rs1163369708 17 dbSNP
rs1174219930 19 dbSNP
rs915488824 20 dbSNP
rs1273558782 21 dbSNP
rs755095016 22 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol FOPNL   
Synonyms C16orf63, FOR20, PHSECRG2
Description FGFR1OP N-terminal like
Transcript NM_144600   
Expression
Putative miRNA Targets on FOPNL
3'UTR of FOPNL
(miRNA target sites are highlighted)		 
>FOPNL|NM_144600|3'UTR
   1 TGCTTTGTTTGGGGTATCTTTTGTCTTAAAATTGTATTATTAATTAAATAACTTATTTATTGTCCCAATGTTACCAAAAT
  81 GCACCACTAATGTTTGTAGAAATTGGAGTTTCTACAAAACACCCCTCATGTTTAACTACATTTGTGAATAAAAGCTAACT
 161 CTTGTCATCTAGCTTATTGGATTTGACTTGAAAAAAAAAGTATTGTTTTTACGAAGTATTTTTTGTTTTTTTGAGATGGA
 241 GTCTCGCTCTGTCACCCAGACTGGAGTGCAGTGGCACGATCTCGGCTCACTGCAATCTCTGCCTCCCGGATTCAAGTGAT
 321 TCTCCTGCCTCAGCCTCCCAAGTAGCTGGGAAAACAGGCCTGTGCCACCACACCGGAGTAGTTTTTGTATTTTTAGTAGA
 401 GATGGGGTTTCACCATGCTGGCCAGGCTGGTCTTGAACTCCTGACCTCAGGTGATCTGTGTGCCCCAGCCTCCCAAAGCG
 481 CTGGGATTACAGGTGTGAGCCACTGAGCCCAGCCATTTAGGAAGTATTATAAAGGCCCTTAAAGTTTGTAAGGAAATGAA
 561 AGGGCTTTGTATTACCTTTTCAATAGGCAACAATGTACTTTTTCTTTCCTTAGACTTTGGCTTACTGGAAGATTTAATTA
 641 AAAGGTAGAGGAGAAGTAAATTTGCTGTAATAATTTTGCTGTAAATAAAACAAAGAGTTTATTTTATTAGATAAAGAATG
 721 TGAAGTAAGCATGAAGAGACAGGCTTTGGGAGAAATACCAGAAAGGGATTTTTCAAAGATGGCATTGTTTAATCTCCGTG
 801 TGGCCCTCGGTTGTGCAATCACAGATGAGCCAGAAGAGGGCCAGCCCCCTACTTGTTTGGGCTCCGAAACTCTTACCAAA
 881 CATCAATTTTTATTCTTGGGATAGAAAAATAGTATGTGCTATCTCTAATACGCTACTTCGATATTTATTAAAGAAGTATT
 961 TTTAATGTAGTGTCCACAGGCTCATTTCATTGAAAACAACTGACTATGATGATAGACAGCTCCTGATTGGCAAAAGTTCG
1041 ATGGTATATTCAGAATTAAATTTTGCCTGCACACCTAAACACTGACAACATTTAGCTTAAAGGTTTTCCATGGAGAAGAG
1121 TGGTAAGAGCTGTAGTTAGCAAAATTGGCATCCTCTTTAGGGTGTCAATTCTGTGCTGCTTTGCAAATTGTTGAAACTTT
1201 TGATTTTCTGTTTGGCAATGCTAGTCAGTGTTCACTTCTTACAGATTAGCCAAGAATTTTTATCTAAATGCAGAAACTTA
1281 TTAATGAAATCCATTTAAACTATACTTACACAACATTTTGGGAGGCCCTGCTGGTAAAATTATATATGGATGCAGAAGTA
1361 TTGCAAGAGTCCATTTTCCATTTTTAAATCTGCAATATCTGATTACATTGATGAATTCCGTTGTATTGTATGTGTGAATA
1441 TAAATATCTGAATTCTCCCGGGGGACTTGGTTTTCGTCCAAGGATGTTGGCAGTGGACACTTAGTTTACCTCAGGAATTG
1521 CAATCATGTAAGACTATATTCGGAAAAAATGCTGGAGTATATAATTTTGGATACTGATATAAAATCATCAAGATGGAAGT
1601 TAAGCAGAATTGTCACGTGTAGTCCATAGCGCTTTTATATGCATTATTCTGTAATTTGTTTGTACTGCGGCAACTTTTTA
1681 TACTTTCAATGTATCATTTAATAAAAAAAATAAGCAAGTCAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' ggCCAGGCAUGUUUGAGACGuc 5'
            | ||  |:||| ||||||  
Target 5' cgGCTCACTGCAATCTCTGCct 3'
 283 - 304 144.00 -16.70
2 
miRNA  3' ggccAGGCAUGUUUGAGACGUc 5'
              ||:||:|  :||:|||| 
Target 5' caatTCTGTGC-TGCTTTGCAa 3'
 1166 - 1186 141.00 -15.20
3 
miRNA  3' ggccAGG-CAUGUUUGAGACGUc 5'
              |||  | : || |||||| 
Target 5' atttTCCATTTTTAAATCTGCAa 3'
 1373 - 1395 122.00 -7.80
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30130215 17 COSMIC
COSN30500838 39 COSMIC
COSN30506771 42 COSMIC
COSN26976621 44 COSMIC
COSN30524777 48 COSMIC
COSN30752187 49 COSMIC
COSN19628337 105 COSMIC
COSN1183596 190 COSMIC
COSN22669349 308 COSMIC
COSN17290820 862 COSMIC
COSN22313235 925 COSMIC
COSN20093084 970 COSMIC
COSN26407862 1168 COSMIC
COSN20112689 1303 COSMIC
COSN23767691 1644 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs761558979 1 dbSNP
rs1266190526 7 dbSNP
rs1205540888 16 dbSNP
rs1411735300 17 dbSNP
rs928389059 19 dbSNP
rs762989983 23 dbSNP
rs1296166990 34 dbSNP
rs375107915 36 dbSNP
rs769862239 38 dbSNP
rs552134239 41 dbSNP
rs781347674 42 dbSNP
rs916067425 43 dbSNP
rs557751461 44 dbSNP
rs1470625763 48 dbSNP
rs539524219 50 dbSNP
rs375461458 52 dbSNP
rs1356239536 55 dbSNP
rs916801856 56 dbSNP
rs984431385 58 dbSNP
rs1285808675 61 dbSNP
rs1486285098 64 dbSNP
rs115567967 65 dbSNP
rs560415453 68 dbSNP
rs1471539388 69 dbSNP
rs1447192833 71 dbSNP
rs972732292 75 dbSNP
rs965430730 77 dbSNP
rs1441204751 87 dbSNP
rs112609106 103 dbSNP
rs12598941 105 dbSNP
rs530055379 108 dbSNP
rs1435198740 115 dbSNP
rs889649955 116 dbSNP
rs953324803 120 dbSNP
rs1021958876 122 dbSNP
rs1447423933 124 dbSNP
rs1298871171 128 dbSNP
rs113494388 130 dbSNP
rs997346226 134 dbSNP
rs901594940 138 dbSNP
rs1308976033 139 dbSNP
rs1349049217 150 dbSNP
rs1221393604 158 dbSNP
rs1429525434 164 dbSNP
rs891712553 177 dbSNP
rs1236435771 191 dbSNP
rs1340089791 196 dbSNP
rs1030718378 200 dbSNP
rs999175456 200 dbSNP
rs1052678867 202 dbSNP
rs80132181 212 dbSNP
rs7498734 213 dbSNP
rs1310847354 218 dbSNP
rs1174202126 223 dbSNP
rs1413882147 225 dbSNP
rs1422949092 225 dbSNP
rs28564648 226 dbSNP
rs1171220653 227 dbSNP
rs1395747705 233 dbSNP
rs1444768506 233 dbSNP
rs1044150486 245 dbSNP
rs948223125 246 dbSNP
rs377651531 249 dbSNP
rs528419784 260 dbSNP
rs1049047379 261 dbSNP
rs1215730117 264 dbSNP
rs894767903 268 dbSNP
rs1319395072 269 dbSNP
rs772178143 277 dbSNP
rs931544010 278 dbSNP
rs745762635 281 dbSNP
rs1200700283 283 dbSNP
rs1244835114 284 dbSNP
rs1477651611 289 dbSNP
rs972701050 290 dbSNP
rs965398355 293 dbSNP
rs12596676 300 dbSNP
rs1167398111 302 dbSNP
rs1475493458 303 dbSNP
rs1170119987 305 dbSNP
rs757353164 307 dbSNP
rs954003499 308 dbSNP
rs1321971390 310 dbSNP
rs1330898840 316 dbSNP
rs1374373082 322 dbSNP
rs938838613 327 dbSNP
rs1216231404 328 dbSNP
rs1256916588 333 dbSNP
rs1021422989 334 dbSNP
rs1268895256 337 dbSNP
rs545852143 342 dbSNP
rs940674047 343 dbSNP
rs1450830759 349 dbSNP
rs955957498 355 dbSNP
rs984832904 359 dbSNP
rs1476821626 360 dbSNP
rs1482022519 361 dbSNP
rs1369184271 366 dbSNP
rs1031580157 371 dbSNP
rs1002478505 373 dbSNP
rs921890046 374 dbSNP
rs1196454935 375 dbSNP
rs1341573725 377 dbSNP
rs1401674793 377 dbSNP
rs1263850893 378 dbSNP
rs975855953 381 dbSNP
rs965855399 391 dbSNP
rs1340568761 402 dbSNP
rs1030719692 405 dbSNP
rs906919717 411 dbSNP
rs781590879 413 dbSNP
rs1355262264 414 dbSNP
rs1217026287 417 dbSNP
rs1244369522 426 dbSNP
rs1215822704 431 dbSNP
rs1256870463 432 dbSNP
rs1341335649 435 dbSNP
rs1295475634 440 dbSNP
rs1368093447 444 dbSNP
rs1440594344 448 dbSNP
rs1160821091 478 dbSNP
rs530614010 479 dbSNP
rs1044119142 480 dbSNP
rs1402247587 492 dbSNP
rs1012634800 493 dbSNP
rs1309177018 504 dbSNP
rs887527465 506 dbSNP
rs1339500835 512 dbSNP
rs1240493660 519 dbSNP
rs1311103908 520 dbSNP
rs563287328 527 dbSNP
rs867324110 534 dbSNP
rs754011057 535 dbSNP
rs1484223563 536 dbSNP
rs1198773184 537 dbSNP
rs894696160 538 dbSNP
rs1458375489 541 dbSNP
rs1180760776 550 dbSNP
rs1236662709 552 dbSNP
rs769202559 556 dbSNP
rs1003018081 569 dbSNP
rs1379843520 571 dbSNP
rs1465039977 576 dbSNP
rs115579688 583 dbSNP
rs1487271384 587 dbSNP
rs1252750310 601 dbSNP
rs560339893 609 dbSNP
rs1332988071 610 dbSNP
rs1374320714 613 dbSNP
rs944016729 619 dbSNP
rs912601038 621 dbSNP
rs543229494 631 dbSNP
rs940752950 645 dbSNP
rs574112140 649 dbSNP
rs1313879212 657 dbSNP
rs768330112 660 dbSNP
rs1255431891 664 dbSNP
rs909338368 673 dbSNP
rs7206519 677 dbSNP
rs914658502 680 dbSNP
rs1457513047 686 dbSNP
rs1182463327 695 dbSNP
rs931995096 701 dbSNP
rs1431883287 702 dbSNP
rs989969659 703 dbSNP
rs921814120 706 dbSNP
rs956092244 708 dbSNP
rs1335710669 709 dbSNP
rs756273679 711 dbSNP
rs1397635980 716 dbSNP
rs975991807 720 dbSNP
rs540851166 728 dbSNP
rs1280599934 729 dbSNP
rs1384942354 731 dbSNP
rs1397222592 739 dbSNP
rs1341161700 743 dbSNP
rs971298486 744 dbSNP
rs540495500 767 dbSNP
rs1256309534 783 dbSNP
rs1329900713 790 dbSNP
rs1222602331 792 dbSNP
rs923749749 794 dbSNP
rs1385794106 797 dbSNP
rs753150410 798 dbSNP
rs968194553 804 dbSNP
rs1479111922 806 dbSNP
rs1013016228 808 dbSNP
rs887507124 809 dbSNP
rs1011879094 813 dbSNP
rs1427484366 816 dbSNP
rs1455398140 817 dbSNP
rs1410995687 821 dbSNP
rs1158968344 823 dbSNP
rs959045195 825 dbSNP
rs1034572406 827 dbSNP
rs1401844133 828 dbSNP
rs1049314835 845 dbSNP
rs995670748 855 dbSNP
rs1471105596 865 dbSNP
rs1229058290 866 dbSNP
rs1315145799 872 dbSNP
rs3743520 876 dbSNP
rs563625925 876 dbSNP
rs1244489224 877 dbSNP
rs1037279091 883 dbSNP
rs369665117 886 dbSNP
rs1215089141 891 dbSNP
rs1005087341 892 dbSNP
rs1198243757 898 dbSNP
rs891384446 899 dbSNP
rs1468968462 901 dbSNP
rs887828476 909 dbSNP
rs1255055998 911 dbSNP
rs1421751734 916 dbSNP
rs1049724016 918 dbSNP
rs932656119 921 dbSNP
rs760064949 927 dbSNP
rs557712505 931 dbSNP
rs931962499 932 dbSNP
rs1285353692 938 dbSNP
rs1225883056 939 dbSNP
rs377756936 940 dbSNP
rs900496804 941 dbSNP
rs752007763 942 dbSNP
rs1304713500 960 dbSNP
rs924416116 962 dbSNP
rs539485288 966 dbSNP
rs981244047 972 dbSNP
rs1310360472 976 dbSNP
rs978294916 977 dbSNP
rs1371116873 980 dbSNP
rs1283953279 983 dbSNP
rs1238545116 986 dbSNP
rs1284214462 987 dbSNP
rs946573694 988 dbSNP
rs569329185 992 dbSNP
rs557126932 999 dbSNP
rs991159059 1004 dbSNP
rs1432396048 1006 dbSNP
rs535963131 1006 dbSNP
rs761453527 1013 dbSNP
rs914950869 1016 dbSNP
rs1482034592 1020 dbSNP
rs1238512666 1023 dbSNP
rs188141011 1025 dbSNP
rs775991752 1039 dbSNP
rs3743519 1040 dbSNP
rs1407136069 1041 dbSNP
rs760217682 1047 dbSNP
rs1034668027 1053 dbSNP
rs897585855 1065 dbSNP
rs1444981841 1066 dbSNP
rs1015728696 1070 dbSNP
rs3743518 1071 dbSNP
rs891353365 1077 dbSNP
rs1221443565 1080 dbSNP
rs1186799332 1087 dbSNP
rs1320834082 1095 dbSNP
rs1050459196 1096 dbSNP
rs1258270603 1101 dbSNP
rs932667415 1106 dbSNP
rs1176531320 1110 dbSNP
rs1232156920 1115 dbSNP
rs1478276512 1118 dbSNP
rs1464596287 1122 dbSNP
rs893163121 1129 dbSNP
rs1027668860 1130 dbSNP
rs184836604 1142 dbSNP
rs115911907 1147 dbSNP
rs1402694951 1150 dbSNP
rs1464312572 1174 dbSNP
rs552199327 1186 dbSNP
rs572501483 1189 dbSNP
rs1040343089 1191 dbSNP
rs777382593 1198 dbSNP
rs192523617 1200 dbSNP
rs902389420 1201 dbSNP
rs1345482395 1202 dbSNP
rs771941369 1218 dbSNP
rs1278343921 1220 dbSNP
rs1212261255 1229 dbSNP
rs745811484 1232 dbSNP
rs1193722649 1235 dbSNP
rs867989392 1238 dbSNP
rs951737297 1241 dbSNP
rs1223618150 1244 dbSNP
rs1266643728 1246 dbSNP
rs1027698998 1250 dbSNP
rs148935179 1256 dbSNP
rs1425884474 1262 dbSNP
rs1360830235 1264 dbSNP
rs961765443 1266 dbSNP
rs937741328 1270 dbSNP
rs1432565540 1277 dbSNP
rs927733404 1281 dbSNP
rs1312158301 1287 dbSNP
rs1018717431 1294 dbSNP
rs981741350 1301 dbSNP
rs112324548 1303 dbSNP
rs1008385454 1305 dbSNP
rs78867389 1307 dbSNP
rs3833040 1308 dbSNP
rs764345722 1308 dbSNP
rs1015569529 1309 dbSNP
rs1224725526 1309 dbSNP
rs983736143 1311 dbSNP
rs1377254422 1314 dbSNP
rs529816991 1315 dbSNP
rs952419500 1318 dbSNP
rs3743517 1319 dbSNP
rs1449013769 1327 dbSNP
rs554559011 1332 dbSNP
rs1217268921 1344 dbSNP
rs1188523652 1347 dbSNP
rs996333263 1351 dbSNP
rs997475709 1353 dbSNP
rs777691635 1358 dbSNP
rs964728951 1360 dbSNP
rs1237228234 1365 dbSNP
rs893393144 1369 dbSNP
rs1471218782 1370 dbSNP
rs1054843269 1383 dbSNP
rs998828562 1385 dbSNP
rs1420780614 1390 dbSNP
rs1160997933 1393 dbSNP
rs1361848840 1394 dbSNP
rs1009289778 1397 dbSNP
rs1486931496 1402 dbSNP
rs903264803 1404 dbSNP
rs902524346 1406 dbSNP
rs145842984 1408 dbSNP
rs1273188535 1415 dbSNP
rs1045818989 1419 dbSNP
rs949883651 1420 dbSNP
rs1042810604 1429 dbSNP
rs1273208997 1431 dbSNP
rs1215994670 1432 dbSNP
rs1257032991 1435 dbSNP
rs1376569759 1436 dbSNP
rs1444275506 1438 dbSNP
rs915761471 1446 dbSNP
rs149855063 1451 dbSNP
rs1054957770 1453 dbSNP
rs756398052 1455 dbSNP
rs1415231077 1459 dbSNP
rs752820605 1460 dbSNP
rs971694227 1463 dbSNP
rs961734550 1464 dbSNP
rs189137827 1465 dbSNP
rs1415776629 1469 dbSNP
rs372897414 1475 dbSNP
rs987254136 1476 dbSNP
rs575506753 1480 dbSNP
rs908191716 1483 dbSNP
rs781551692 1485 dbSNP
rs1355212480 1498 dbSNP
rs1028871069 1499 dbSNP
rs1172668865 1500 dbSNP
rs1333905777 1504 dbSNP
rs997042847 1507 dbSNP
rs1238249852 1509 dbSNP
rs984231479 1511 dbSNP
rs11129 1521 dbSNP
rs1033298331 1526 dbSNP
rs751917716 1529 dbSNP
rs974842460 1536 dbSNP
rs140202606 1538 dbSNP
rs3743515 1541 dbSNP
rs553197810 1542 dbSNP
rs1200233250 1548 dbSNP
rs1377662819 1552 dbSNP
rs1481115675 1553 dbSNP
rs1250171625 1555 dbSNP
rs1008969926 1557 dbSNP
rs1404885935 1560 dbSNP
rs751319305 1569 dbSNP
rs1045783229 1572 dbSNP
rs1299603506 1574 dbSNP
rs1394086665 1576 dbSNP
rs534862412 1589 dbSNP
rs1390698619 1591 dbSNP
rs1301932416 1598 dbSNP
rs1048813 1604 dbSNP
rs1221737764 1611 dbSNP
rs375553573 1616 dbSNP
rs894560998 1617 dbSNP
rs753432212 1619 dbSNP
rs1200759523 1621 dbSNP
rs1056008962 1626 dbSNP
rs1249914135 1627 dbSNP
rs1210858910 1630 dbSNP
rs774693529 1630 dbSNP
rs1206070756 1631 dbSNP
rs1270072377 1658 dbSNP
rs893694228 1659 dbSNP
rs1319541042 1664 dbSNP
rs11642 1668 dbSNP
rs760400607 1669 dbSNP
rs1233607049 1680 dbSNP
rs1172119510 1683 dbSNP
rs1336693932 1687 dbSNP
rs763294650 1689 dbSNP
rs940331715 1691 dbSNP
rs1367353909 1696 dbSNP
rs537369384 1700 dbSNP
rs911526680 1703 dbSNP
rs1046690145 1711 dbSNP
rs1299951840 1712 dbSNP
rs1434484724 1719 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions TZM-bl
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM1462574. RNA binding protein: AGO2. Condition:TZM-bl ami BaL ...

- Whisnant AW; Bogerd HP; Flores O; Ho P; et al., 2013, mBio.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' ggccAGG-CAUGUUUGAGACGUc 5'
              |||  | : || |||||| 
Target 5' auuuUCCAUUUUUAAAUCUGCAa 3'
 		4 - 26
Article - Whisnant AW; Bogerd HP; Flores O; Ho P; et al.
- mBio, 2013
UNLABELLED: The question of how HIV-1 interfaces with cellular microRNA (miRNA) biogenesis and effector mechanisms has been highly controversial. Here, we first used deep sequencing of small RNAs present in two different infected cell lines (TZM-bl and C8166) and two types of primary human cells (CD4(+) peripheral blood mononuclear cells [PBMCs] and macrophages) to unequivocally demonstrate that HIV-1 does not encode any viral miRNAs. Perhaps surprisingly, we also observed that infection of T cells by HIV-1 has only a modest effect on the expression of cellular miRNAs at early times after infection. Comprehensive analysis of miRNA binding to the HIV-1 genome using the photoactivatable ribonucleoside-induced cross-linking and immunoprecipitation (PAR-CLIP) technique revealed several binding sites for cellular miRNAs, a subset of which were shown to be capable of mediating miRNA-mediated repression of gene expression. However, the main finding from this analysis is that HIV-1 transcripts are largely refractory to miRNA binding, most probably due to extensive viral RNA secondary structure. Together, these data demonstrate that HIV-1 neither encodes viral miRNAs nor strongly influences cellular miRNA expression, at least early after infection, and imply that HIV-1 transcripts have evolved to avoid inhibition by preexisting cellular miRNAs by adopting extensive RNA secondary structures that occlude most potential miRNA binding sites. IMPORTANCE: MicroRNAs (miRNAs) are a ubiquitous class of small regulatory RNAs that serve as posttranscriptional regulators of gene expression. Previous work has suggested that HIV-1 might subvert the function of the cellular miRNA machinery by expressing viral miRNAs or by dramatically altering the level of cellular miRNA expression. Using very sensitive approaches, we now demonstrate that neither of these ideas is in fact correct. Moreover, HIV-1 transcripts appear to largely avoid regulation by cellular miRNAs by adopting an extensive RNA secondary structure that occludes the ability of cellular miRNAs to interact with viral mRNAs. Together, these data suggest that HIV-1, rather than seeking to control miRNA function in infected cells, has instead evolved a mechanism to become largely invisible to cellular miRNA effector mechanisms.
LinkOut: [PMID: 23592263]
CLIP-seq Support 1 for dataset GSM1462574
Method / RBP PAR-CLIP / AGO2
Cell line / Condition TZM-bl / TZM-bl ami BaL
Location of target site ENST00000573396.1 | 3UTR | UCCAUUUUCCAUUUUUAAAUCUGCAAUAUCUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23592263 / GSE59944
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
LUSC -0.714 0.14 -0.600 0.2 4 Click to see details
HNSC 0.351 0.14 0.200 0.28 11 Click to see details
LIHC 0.028 0.47 -0.050 0.45 9 Click to see details
LIHC 0.028 0.47 -0.050 0.45 9 Click to see details
LIHC 0.028 0.47 -0.050 0.45 9 Click to see details
LIHC 0.028 0.47 -0.050 0.45 9 Click to see details
LIHC 0.028 0.47 -0.050 0.45 9 Click to see details
LIHC 0.028 0.47 -0.050 0.45 9 Click to see details
LIHC 0.028 0.47 -0.050 0.45 9 Click to see details
LIHC 0.028 0.47 -0.050 0.45 9 Click to see details
LIHC 0.028 0.47 -0.050 0.45 9 Click to see details
LIHC 0.028 0.47 -0.050 0.45 9 Click to see details
86 hsa-miR-3678-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT074327 TNRC6A trinucleotide repeat containing 6A 2 10
MIRT107705 CLTA clathrin light chain A 2 2
MIRT114113 AGO1 argonaute 1, RISC catalytic component 2 2
MIRT155293 IFNAR2 interferon alpha and beta receptor subunit 2 2 4
MIRT159171 NRBP1 nuclear receptor binding protein 1 2 2
MIRT185795 ZNF678 zinc finger protein 678 2 2
MIRT282672 SYNM synemin 2 2
MIRT294386 ZNF264 zinc finger protein 264 2 2
MIRT295818 CHMP4B charged multivesicular body protein 4B 2 2
MIRT332777 CAPRIN1 cell cycle associated protein 1 2 4
MIRT334112 PPP6R3 protein phosphatase 6 regulatory subunit 3 2 2
MIRT340971 IPO5 importin 5 2 2
MIRT354679 CDV3 CDV3 homolog 2 2
MIRT366662 PLP2 proteolipid protein 2 2 2
MIRT404272 PLEKHA8 pleckstrin homology domain containing A8 2 2
MIRT447536 RNF165 ring finger protein 165 2 2
MIRT449139 UQCRB ubiquinol-cytochrome c reductase binding protein 2 2
MIRT451301 LGALS3BP galectin 3 binding protein 2 2
MIRT451488 FOPNL FGFR1OP N-terminal like 2 2
MIRT455198 GNL1 G protein nucleolar 1 (putative) 2 2
MIRT459215 MRPS21 mitochondrial ribosomal protein S21 2 2
MIRT461764 MPDU1 mannose-P-dolichol utilization defect 1 2 2
MIRT463273 ZFX zinc finger protein, X-linked 2 2
MIRT464862 UBB ubiquitin B 2 8
MIRT464950 TWIST1 twist family bHLH transcription factor 1 2 2
MIRT467378 SON SON DNA binding protein 2 4
MIRT469282 RHOA ras homolog family member A 2 2
MIRT470293 PPTC7 PTC7 protein phosphatase homolog 2 2
MIRT470639 POM121C POM121 transmembrane nucleoporin C 2 2
MIRT477163 FABP3 fatty acid binding protein 3 2 2
MIRT477686 EFHD2 EF-hand domain family member D2 2 2
MIRT479725 CCNF cyclin F 2 2
MIRT481726 APH1A aph-1 homolog A, gamma-secretase subunit 2 2
MIRT485673 CCDC64 BICD family like cargo adaptor 1 2 2
MIRT498280 PADI2 peptidyl arginine deiminase 2 2 2
MIRT499921 GPX8 glutathione peroxidase 8 (putative) 2 2
MIRT503616 SLC25A36 solute carrier family 25 member 36 2 4
MIRT506927 IGDCC4 immunoglobulin superfamily DCC subclass member 4 2 6
MIRT507348 FAM129A family with sequence similarity 129 member A 2 6
MIRT508265 DYNLL2 dynein light chain LC8-type 2 2 4
MIRT508284 YES1 YES proto-oncogene 1, Src family tyrosine kinase 2 4
MIRT509353 COPS8 COP9 signalosome subunit 8 2 2
MIRT510892 RAB1A RAB1A, member RAS oncogene family 2 4
MIRT511882 GAS1 growth arrest specific 1 2 6
MIRT511990 E2F1 E2F transcription factor 1 2 4
MIRT512239 ARPP19 cAMP regulated phosphoprotein 19 2 4
MIRT512392 BUB1 BUB1 mitotic checkpoint serine/threonine kinase 2 4
MIRT514086 EPS15L1 epidermal growth factor receptor pathway substrate 15 like 1 2 6
MIRT514358 UBBP4 ubiquitin B pseudogene 4 2 6
MIRT523149 HNRNPU heterogeneous nuclear ribonucleoprotein U 2 2
MIRT525511 FSIP2 fibrous sheath interacting protein 2 2 2
MIRT526333 SH3TC2 SH3 domain and tetratricopeptide repeats 2 2 2
MIRT529962 ZNF71 zinc finger protein 71 2 2
MIRT530337 GABRB3 gamma-aminobutyric acid type A receptor beta3 subunit 2 2
MIRT530884 PHOX2A paired like homeobox 2a 2 2
MIRT533097 YOD1 YOD1 deubiquitinase 2 2
MIRT533250 VCAM1 vascular cell adhesion molecule 1 2 2
MIRT534786 RAB8B RAB8B, member RAS oncogene family 2 2
MIRT537917 DSTYK dual serine/threonine and tyrosine protein kinase 2 2
MIRT547799 JARID2 jumonji and AT-rich interaction domain containing 2 2 2
MIRT548714 CRK CRK proto-oncogene, adaptor protein 2 2
MIRT555509 PMEPA1 prostate transmembrane protein, androgen induced 1 2 2
MIRT555984 NFYB nuclear transcription factor Y subunit beta 2 2
MIRT557942 FAM222B family with sequence similarity 222 member B 2 2
MIRT560830 ZNF786 zinc finger protein 786 2 2
MIRT562720 ZNF714 zinc finger protein 714 2 2
MIRT565337 TMEM104 transmembrane protein 104 2 2
MIRT614453 REL REL proto-oncogene, NF-kB subunit 2 2
MIRT639474 SLC6A4 solute carrier family 6 member 4 2 2
MIRT644056 IQCE IQ motif containing E 2 2
MIRT651652 VWA1 von Willebrand factor A domain containing 1 2 2
MIRT651866 UNC119B unc-119 lipid binding chaperone B 2 2
MIRT653490 SLC43A2 solute carrier family 43 member 2 2 2
MIRT657039 KCNJ6 potassium voltage-gated channel subfamily J member 6 2 2
MIRT657985 GAN gigaxonin 2 2
MIRT672117 ATP6V0A2 ATPase H+ transporting V0 subunit a2 2 2
MIRT683583 GSTCD glutathione S-transferase C-terminal domain containing 2 2
MIRT688689 CPS1 carbamoyl-phosphate synthase 1 2 2
MIRT695375 NSA2 NSA2, ribosome biogenesis homolog 2 2
MIRT696351 EIF2S3 eukaryotic translation initiation factor 2 subunit gamma 2 2
MIRT700614 PRKAA2 protein kinase AMP-activated catalytic subunit alpha 2 2 2
MIRT703512 FKBP15 FK506 binding protein 15 2 2
MIRT705051 C5orf15 chromosome 5 open reading frame 15 2 2
MIRT705180 BTG1 BTG anti-proliferation factor 1 2 2
MIRT709409 FBXL20 F-box and leucine rich repeat protein 20 2 2
MIRT721053 DCC DCC netrin 1 receptor 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-3678-3p Platinum 23939 resistant tissue
hsa-miR-3678-3p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-3678-3p Gemcitabine 60750 NSC613327 approved resistant cell line (PANC-1) (1500 ng/ml)
hsa-miR-3678-3p Paclitaxel/Docetaxel/Vinorelbine/Doxorubicin/Etoposide resistant cell line (Bads-200)

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