miRTarBase - #MIRT451792


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pre-miRNA Information
pre-miRNA hsa-mir-4271   
Genomic Coordinates chr3: 49274120 - 49274186
Description Homo sapiens miR-4271 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-4271
Sequence 39| GGGGGAAGAAAAGGUGGGG |57
Evidence Experimental
Experiments SOLiD
DRVs in miRNA
Mutant ID Mutant Position Mutant Source
COSN30481495 1 COSMIC
COSN31532060 5 COSMIC
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs760829741 1 dbSNP
rs1277951968 2 dbSNP
rs189148716 3 dbSNP
rs757021935 4 dbSNP
rs1285201145 6 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol TLR5   
Synonyms MELIOS, SLE1, SLEB1, TIL3
Description toll like receptor 5
Transcript NM_003268   
Expression
Putative miRNA Targets on TLR5
3'UTR of TLR5
(miRNA target sites are highlighted)		 
>TLR5|NM_003268|3'UTR
   1 TCAAAGGAGCAATTTCCAACTTATCTCAAGCCACAAATAACTCTTCACTTTGTATTTGCACCAAGTTATCATTTTGGGGT
  81 CCTCTCTGGAGGTTTTTTTTTTCTTTTTGCTACTATGAAAACAACATAAATCTCTCAATTTTCGTATCAACACCATGTTC
 161 TGTCTCACTAACCTCCAAATGGAAAATAATAGATCTAGAAAATTGCAACTGCCCTTAGAGGTTTCCAGTCTCCATTGATT
 241 TTCTTTCAGATCCAATAATACCGTTCTGTCCTGCTGTGTTGATTATGGAATGTATCCTAATCATGGGAAGGGCACCTTGG
 321 GAGAAGTTGCAGATGGCTGACGTGCTTTCTCTAGCATTCAGCTAAAAAATGGGATGGTCCATGATTCTGCGTTCTCTGTG
 401 TTCTGCAAAACAACATTAAGTAGAAAACAAACAGAAGCAGAGGCACATTTCCTTCTTTTGCCACAGAAACAATGCCACTG
 481 TTGAGTGCAAGTCACACTTTGTCTCATAGATAAGAGGTGGCCCCAAAGAAGCTGGGATGAATGAGTCACTACCTGTCTTG
 561 TGACTGTACTGCACTTCATGTTCTTACCTTCGGCTTCTCCAGGTCTCGCCCTAGTGAGCCAAGAACTTTCTCTCACATGC
 641 TGCCTTTATTTAAGCCTGGCCTTCAAGACCTTCCATGATTTATCACCAACCTACCTTTTCAGCTTTGTTTCCTAGCACAC
 721 CTCATTGATCAGCTGCTCAGGCTGTTGCATGAAGAACATGGACTTTGCACACAGATCCTGGGTTGAGTTCTGAGTCAGCT
 801 GTGTATTAGCCATGTAACCTTGGCCTTGGTATGCCCTTGCTGGACCTACATTTTCTCACGTAACAGCATCTATGTCATAG
 881 AATTCCTGTGAAAATTAAATTGGCCAAGGATGTCAGGGCTTCTCAGATCTTTTCCTTCGTTGCCCTAATGACCACAAGAG
 961 AACACATACACTGAAGGCCTCCTGGGGGGCAGTTGCAATTTCACTGAAGTTGTATTTTTTTATCTTAAATGAAATCTATG
1041 TGTATTTTCAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' ggGGUGGAA-AAGAAGGGGg 5'
            ::|||||   ||||:|| 
Target 5' tcTTACCTTCGGCTTCTCCa 3'
 582 - 601 137.00 -20.10
2 
miRNA  3' gggGUGGAAAAGAAGGGGg 5'
             ||| ||| ||||::: 
Target 5' aggCACATTTCCTTCTTTt 3'
 441 - 459 116.00 -9.40
3 
miRNA  3' ggGGUGGAAAAGAAGGGgg 5'
            :|| |||| :||||:  
Target 5' ttTCAGCTTTGTTTCCTag 3'
 697 - 715 113.00 -11.70
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30165861 1 COSMIC
COSN30165573 25 COSMIC
COSN31520226 56 COSMIC
COSN31581672 59 COSMIC
COSN30473901 77 COSMIC
COSN30487092 82 COSMIC
COSN30455835 84 COSMIC
COSN30178585 88 COSMIC
COSN30178611 89 COSMIC
COSN30532685 92 COSMIC
COSN28867206 93 COSMIC
COSN30112048 103 COSMIC
COSN13519349 143 COSMIC
COSN4748316 320 COSMIC
COSN15567196 343 COSMIC
COSN25998601 465 COSMIC
COSN20165530 747 COSMIC
COSN7205517 859 COSMIC
COSN20936930 950 COSMIC
COSN7205516 982 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1264358299 2 dbSNP
rs1199216719 4 dbSNP
rs752097284 11 dbSNP
rs1278979017 22 dbSNP
rs1200759749 24 dbSNP
rs1210999489 26 dbSNP
rs1349519705 27 dbSNP
rs753877623 29 dbSNP
rs764529751 34 dbSNP
rs759055505 35 dbSNP
rs5744178 36 dbSNP
rs550570603 37 dbSNP
rs766066480 44 dbSNP
rs1374783623 45 dbSNP
rs1259359261 46 dbSNP
rs1019520262 48 dbSNP
rs1336588414 61 dbSNP
rs1181428984 69 dbSNP
rs1405125163 73 dbSNP
rs539847930 79 dbSNP
rs1008165980 80 dbSNP
rs892443937 81 dbSNP
rs918753955 83 dbSNP
rs1376661188 86 dbSNP
rs1037317070 92 dbSNP
rs1052878464 93 dbSNP
rs1000924037 94 dbSNP
rs903939088 101 dbSNP
rs1311757827 103 dbSNP
rs533301769 103 dbSNP
rs748851240 103 dbSNP
rs927081386 103 dbSNP
rs958365286 103 dbSNP
rs1223128948 109 dbSNP
rs572130714 112 dbSNP
rs1282171080 116 dbSNP
rs1348374967 120 dbSNP
rs1372775869 133 dbSNP
rs1471355544 136 dbSNP
rs1280191488 143 dbSNP
rs5744179 144 dbSNP
rs1481585129 148 dbSNP
rs971228259 150 dbSNP
rs948236504 151 dbSNP
rs1392596683 154 dbSNP
rs1452176462 155 dbSNP
rs1325395586 166 dbSNP
rs1397233840 168 dbSNP
rs765456726 172 dbSNP
rs1056755711 173 dbSNP
rs1168374030 173 dbSNP
rs561329538 187 dbSNP
rs1353206344 190 dbSNP
rs1463982841 194 dbSNP
rs1298814083 197 dbSNP
rs866853507 201 dbSNP
rs183724766 203 dbSNP
rs762013954 205 dbSNP
rs1367058950 206 dbSNP
rs1438943716 213 dbSNP
rs1305853792 227 dbSNP
rs1351971889 234 dbSNP
rs908172093 235 dbSNP
rs982862115 237 dbSNP
rs957534200 238 dbSNP
rs1309185227 255 dbSNP
rs562813188 257 dbSNP
rs1007309036 262 dbSNP
rs528324510 263 dbSNP
rs1179993851 270 dbSNP
rs1451987765 274 dbSNP
rs5744180 278 dbSNP
rs143922768 284 dbSNP
rs5744181 287 dbSNP
rs562869567 290 dbSNP
rs1417895876 292 dbSNP
rs963871313 300 dbSNP
rs1037625775 304 dbSNP
rs1394436617 315 dbSNP
rs941501281 318 dbSNP
rs774889989 320 dbSNP
rs777082049 327 dbSNP
rs1258732059 334 dbSNP
rs146126096 336 dbSNP
rs1268188472 337 dbSNP
rs764455534 341 dbSNP
rs574123901 342 dbSNP
rs761218460 354 dbSNP
rs1286212943 365 dbSNP
rs1055375375 372 dbSNP
rs1368805821 378 dbSNP
rs1214949261 381 dbSNP
rs555793815 384 dbSNP
rs5744182 389 dbSNP
rs917949 390 dbSNP
rs1213285066 391 dbSNP
rs1370233539 402 dbSNP
rs1476571879 406 dbSNP
rs1287462624 413 dbSNP
rs1417704974 414 dbSNP
rs368541999 415 dbSNP
rs1346336007 421 dbSNP
rs1167192046 428 dbSNP
rs1418744451 432 dbSNP
rs1045202639 462 dbSNP
rs1432338110 465 dbSNP
rs1316546177 468 dbSNP
rs1393938490 470 dbSNP
rs1012402159 477 dbSNP
rs1431129379 481 dbSNP
rs896630905 491 dbSNP
rs5744183 497 dbSNP
rs940917564 501 dbSNP
rs34348716 504 dbSNP
rs908120497 505 dbSNP
rs957192412 509 dbSNP
rs1293354302 511 dbSNP
rs776209518 517 dbSNP
rs35942519 519 dbSNP
rs144752838 522 dbSNP
rs1046722576 541 dbSNP
rs556812460 545 dbSNP
rs1285858099 547 dbSNP
rs867439281 552 dbSNP
rs1033375065 555 dbSNP
rs985389225 558 dbSNP
rs1257342450 561 dbSNP
rs1861172 563 dbSNP
rs919669836 564 dbSNP
rs1418630803 565 dbSNP
rs998165489 573 dbSNP
rs1156914834 577 dbSNP
rs1410363591 577 dbSNP
rs5744184 579 dbSNP
rs1208627146 580 dbSNP
rs1015646208 581 dbSNP
rs1416520962 587 dbSNP
rs546150029 591 dbSNP
rs528387974 592 dbSNP
rs912362711 593 dbSNP
rs149345961 607 dbSNP
rs1234302508 611 dbSNP
rs139063884 623 dbSNP
rs1031369811 627 dbSNP
rs1293648471 632 dbSNP
rs1346222099 641 dbSNP
rs1213503138 642 dbSNP
rs1055809081 652 dbSNP
rs938253345 655 dbSNP
rs1000860156 657 dbSNP
rs370349085 666 dbSNP
rs530652147 673 dbSNP
rs1470626960 675 dbSNP
rs1193294865 676 dbSNP
rs1393003934 682 dbSNP
rs1436301557 683 dbSNP
rs1174045327 695 dbSNP
rs563490386 697 dbSNP
rs1300649091 700 dbSNP
rs1045391355 701 dbSNP
rs1408206152 703 dbSNP
rs191365862 704 dbSNP
rs5744185 713 dbSNP
rs748823497 715 dbSNP
rs1012307402 716 dbSNP
rs5744186 718 dbSNP
rs5744187 719 dbSNP
rs386639724 720 dbSNP
rs935869468 720 dbSNP
rs1370991444 724 dbSNP
rs779819255 725 dbSNP
rs1169242264 747 dbSNP
rs1005498724 749 dbSNP
rs1194649830 775 dbSNP
rs886683103 778 dbSNP
rs925788350 781 dbSNP
rs1185765641 790 dbSNP
rs1485292121 818 dbSNP
rs1251310857 821 dbSNP
rs1455750942 822 dbSNP
rs1194026761 825 dbSNP
rs188634935 831 dbSNP
rs1049804096 843 dbSNP
rs558191956 844 dbSNP
rs898139513 859 dbSNP
rs1039354033 860 dbSNP
rs1323330764 864 dbSNP
rs1396140035 866 dbSNP
rs1249847490 871 dbSNP
rs1302399174 871 dbSNP
rs756872755 873 dbSNP
rs942415350 874 dbSNP
rs1225836849 879 dbSNP
rs41444749 881 dbSNP
rs1272393189 884 dbSNP
rs41497053 885 dbSNP
rs912351857 888 dbSNP
rs1226946496 889 dbSNP
rs546459059 905 dbSNP
rs1016134632 907 dbSNP
rs1469980914 912 dbSNP
rs575786298 935 dbSNP
rs76220310 938 dbSNP
rs184083581 939 dbSNP
rs1355422821 946 dbSNP
rs1002303820 948 dbSNP
rs5744188 949 dbSNP
rs1397287351 954 dbSNP
rs968004074 956 dbSNP
rs1419466349 957 dbSNP
rs1461619907 964 dbSNP
rs1046597796 973 dbSNP
rs56158064 978 dbSNP
rs144352331 981 dbSNP
rs373203440 981 dbSNP
rs45508499 981 dbSNP
rs5744189 982 dbSNP
rs386639723 983 dbSNP
rs398103748 984 dbSNP
rs5744190 984 dbSNP
rs368623264 988 dbSNP
rs5744191 993 dbSNP
rs772935836 1005 dbSNP
rs960776614 1007 dbSNP
rs1162553519 1012 dbSNP
rs372855080 1013 dbSNP
rs567977101 1014 dbSNP
rs1291485423 1022 dbSNP
rs925673249 1022 dbSNP
rs114816133 1036 dbSNP
rs769517713 1038 dbSNP
rs1348832864 1044 dbSNP
rs530833199 1052 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions TZM-bl
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM1462574. RNA binding protein: AGO2. Condition:TZM-bl ami BaL ...

- Whisnant AW; Bogerd HP; Flores O; Ho P; et al., 2013, mBio.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' ggggUGGAAAAGAAGGGGg 5'
              |||  ||||||||| 
Target 5' ----ACC--UUCUUCCCCu 3'
 		1 - 13
Article - Whisnant AW; Bogerd HP; Flores O; Ho P; et al.
- mBio, 2013
UNLABELLED: The question of how HIV-1 interfaces with cellular microRNA (miRNA) biogenesis and effector mechanisms has been highly controversial. Here, we first used deep sequencing of small RNAs present in two different infected cell lines (TZM-bl and C8166) and two types of primary human cells (CD4(+) peripheral blood mononuclear cells [PBMCs] and macrophages) to unequivocally demonstrate that HIV-1 does not encode any viral miRNAs. Perhaps surprisingly, we also observed that infection of T cells by HIV-1 has only a modest effect on the expression of cellular miRNAs at early times after infection. Comprehensive analysis of miRNA binding to the HIV-1 genome using the photoactivatable ribonucleoside-induced cross-linking and immunoprecipitation (PAR-CLIP) technique revealed several binding sites for cellular miRNAs, a subset of which were shown to be capable of mediating miRNA-mediated repression of gene expression. However, the main finding from this analysis is that HIV-1 transcripts are largely refractory to miRNA binding, most probably due to extensive viral RNA secondary structure. Together, these data demonstrate that HIV-1 neither encodes viral miRNAs nor strongly influences cellular miRNA expression, at least early after infection, and imply that HIV-1 transcripts have evolved to avoid inhibition by preexisting cellular miRNAs by adopting extensive RNA secondary structures that occlude most potential miRNA binding sites. IMPORTANCE: MicroRNAs (miRNAs) are a ubiquitous class of small regulatory RNAs that serve as posttranscriptional regulators of gene expression. Previous work has suggested that HIV-1 might subvert the function of the cellular miRNA machinery by expressing viral miRNAs or by dramatically altering the level of cellular miRNA expression. Using very sensitive approaches, we now demonstrate that neither of these ideas is in fact correct. Moreover, HIV-1 transcripts appear to largely avoid regulation by cellular miRNAs by adopting an extensive RNA secondary structure that occludes the ability of cellular miRNAs to interact with viral mRNAs. Together, these data suggest that HIV-1, rather than seeking to control miRNA function in infected cells, has instead evolved a mechanism to become largely invisible to cellular miRNA effector mechanisms.
LinkOut: [PMID: 23592263]
CLIP-seq Support 1 for dataset GSM1462574
Method / RBP PAR-CLIP / AGO2
Cell line / Condition TZM-bl / TZM-bl ami BaL
Location of target site ENST00000540964.1 | 3UTR | ACCUUCUUCCCCUCACUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23592263 / GSE59944
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
181 hsa-miR-4271 Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT066209 MARCH9 membrane associated ring-CH-type finger 9 2 2
MIRT079367 CCDC137 coiled-coil domain containing 137 2 2
MIRT081183 MIDN midnolin 2 4
MIRT083278 ZCCHC3 zinc finger CCHC-type containing 3 2 6
MIRT086207 HOXD13 homeobox D13 2 2
MIRT133713 SKI SKI proto-oncogene 2 4
MIRT150653 SLC27A1 solute carrier family 27 member 1 2 2
MIRT159166 NRBP1 nuclear receptor binding protein 1 2 2
MIRT160059 TET3 tet methylcytosine dioxygenase 3 2 4
MIRT180856 RPRD2 regulation of nuclear pre-mRNA domain containing 2 2 2
MIRT181931 MARK2 microtubule affinity regulating kinase 2 2 2
MIRT190628 BCL2L2-PABPN1 BCL2L2-PABPN1 readthrough 2 2
MIRT190654 PABPN1 poly(A) binding protein nuclear 1 2 2
MIRT196107 MPRIP myosin phosphatase Rho interacting protein 2 2
MIRT263248 SGPL1 sphingosine-1-phosphate lyase 1 2 2
MIRT321168 EIF4H eukaryotic translation initiation factor 4H 2 2
MIRT338624 SHMT2 serine hydroxymethyltransferase 2 2 2
MIRT366301 GDI1 GDP dissociation inhibitor 1 2 4
MIRT375172 ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 2 2
MIRT441488 NCEH1 neutral cholesterol ester hydrolase 1 2 2
MIRT442333 WNT9B Wnt family member 9B 2 2
MIRT443889 CNKSR3 CNKSR family member 3 2 2
MIRT445880 WBP1L WW domain binding protein 1 like 2 2
MIRT449312 MRO maestro 2 2
MIRT449844 BCL2L13 BCL2 like 13 2 2
MIRT450304 DRAXIN dorsal inhibitory axon guidance protein 2 2
MIRT450515 EMX1 empty spiracles homeobox 1 2 2
MIRT451243 ZNF444 zinc finger protein 444 2 2
MIRT451713 OLR1 oxidized low density lipoprotein receptor 1 2 2
MIRT451792 TLR5 toll like receptor 5 2 2
MIRT451823 ALDH3B1 aldehyde dehydrogenase 3 family member B1 2 2
MIRT451906 ILK integrin linked kinase 2 2
MIRT452181 KIAA1456 KIAA1456 2 4
MIRT452242 TRAM1 translocation associated membrane protein 1 2 2
MIRT452544 ZNF467 zinc finger protein 467 2 2
MIRT452605 REPIN1 replication initiator 1 2 2
MIRT454505 ZFYVE27 zinc finger FYVE-type containing 27 2 2
MIRT454657 FBXL18 F-box and leucine rich repeat protein 18 2 2
MIRT455354 KDM5C lysine demethylase 5C 2 2
MIRT455452 EPB41L4B erythrocyte membrane protein band 4.1 like 4B 2 2
MIRT455587 TAF12 TATA-box binding protein associated factor 12 2 2
MIRT456501 PFKFB2 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 2 2
MIRT456815 PIGP phosphatidylinositol glycan anchor biosynthesis class P 2 2
MIRT457425 NOL10 nucleolar protein 10 2 2
MIRT457468 SLC35F6 solute carrier family 35 member F6 2 2
MIRT457660 SERINC1 serine incorporator 1 2 2
MIRT458231 NXPH3 neurexophilin 3 2 2
MIRT458374 ITM2C integral membrane protein 2C 2 2
MIRT458667 GPR35 G protein-coupled receptor 35 2 2
MIRT459665 VPS37C VPS37C, ESCRT-I subunit 2 2
MIRT459825 TPP1 tripeptidyl peptidase 1 2 2
MIRT460564 FEM1A fem-1 homolog A 2 2
MIRT460725 ASXL3 additional sex combs like 3, transcriptional regulator 2 2
MIRT461121 RAB36 RAB36, member RAS oncogene family 2 2
MIRT461529 C14orf1 ergosterol biosynthesis 28 homolog 2 2
MIRT461750 DDX11 DEAD/H-box helicase 11 2 2
MIRT462570 STS steroid sulfatase 2 2
MIRT462798 NTN1 netrin 1 2 2
MIRT463030 ZNF689 zinc finger protein 689 2 2
MIRT463991 WDTC1 WD and tetratricopeptide repeats 1 2 2
MIRT464684 UBE2V1 ubiquitin conjugating enzyme E2 V1 2 2
MIRT465439 TP53 tumor protein p53 2 2
MIRT465512 PRICKLE4 prickle planar cell polarity protein 4 2 2
MIRT465649 TNPO2 transportin 2 2 10
MIRT465947 TMEM189-UBE2V1 TMEM189-UBE2V1 readthrough 2 2
MIRT466028 TMEM189 transmembrane protein 189 2 2
MIRT468076 SHOC2 SHOC2, leucine rich repeat scaffold protein 2 6
MIRT468131 SH3PXD2A SH3 and PX domains 2A 2 2
MIRT468498 SESN2 sestrin 2 2 2
MIRT468879 RREB1 ras responsive element binding protein 1 2 2
MIRT469318 RGP1 RGP1 homolog, RAB6A GEF complex partner 1 2 2
MIRT469558 RARA retinoic acid receptor alpha 2 2
MIRT469793 RAB15 RAB15, member RAS oncogene family 2 2
MIRT469896 PTRF caveolae associated protein 1 2 2
MIRT470235 PRRC2A proline rich coiled-coil 2A 2 2
MIRT470808 PLXND1 plexin D1 2 2
MIRT471597 PAQR5 progestin and adipoQ receptor family member 5 2 10
MIRT471710 OTUB1 OTU deubiquitinase, ubiquitin aldehyde binding 1 2 2
MIRT471752 OGT O-linked N-acetylglucosamine (GlcNAc) transferase 2 2
MIRT472978 MRRF mitochondrial ribosome recycling factor 2 2
MIRT473538 MAX MYC associated factor X 2 2
MIRT473581 MAT2A methionine adenosyltransferase 2A 2 2
MIRT473970 LRRC58 leucine rich repeat containing 58 2 2
MIRT474223 LCOR ligand dependent nuclear receptor corepressor 2 4
MIRT474553 KLHDC3 kelch domain containing 3 2 2
MIRT474777 KIAA0895L KIAA0895 like 2 2
MIRT476042 GRSF1 G-rich RNA sequence binding factor 1 2 2
MIRT476438 GBA2 glucosylceramidase beta 2 2 2
MIRT477773 E2F3 E2F transcription factor 3 2 4
MIRT477946 DPM2 dolichyl-phosphate mannosyltransferase subunit 2, regulatory 2 2
MIRT478782 CRTC2 CREB regulated transcription coactivator 2 2 2
MIRT479320 VPS72 vacuolar protein sorting 72 homolog 2 2
MIRT480405 C19orf47 chromosome 19 open reading frame 47 2 2
MIRT480593 BTRC beta-transducin repeat containing E3 ubiquitin protein ligase 2 2
MIRT480963 BBC3 BCL2 binding component 3 2 2
MIRT481127 AZIN1 antizyme inhibitor 1 2 4
MIRT481444 ARRB2 arrestin beta 2 2 2
MIRT481687 AR androgen receptor 2 2
MIRT481730 APH1A aph-1 homolog A, gamma-secretase subunit 2 2
MIRT482386 AEN apoptosis enhancing nuclease 2 2
MIRT482564 ABHD2 abhydrolase domain containing 2 2 2
MIRT482605 ABHD14B abhydrolase domain containing 14B 2 2
MIRT483256 CITED4 Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 4 2 4
MIRT483531 TAGLN2 transgelin 2 2 2
MIRT483840 UNC5B unc-5 netrin receptor B 2 4
MIRT483935 LENG8 leukocyte receptor cluster member 8 2 4
MIRT484414 SNX19 sorting nexin 19 2 2
MIRT484487 SLC9A1 solute carrier family 9 member A1 2 2
MIRT484609 SIX3 SIX homeobox 3 2 6
MIRT484703 RNF11 ring finger protein 11 2 2
MIRT485244 POGZ pogo transposable element derived with ZNF domain 2 2
MIRT485607 FOSL1 FOS like 1, AP-1 transcription factor subunit 2 4
MIRT485965 RTBDN retbindin 2 2
MIRT487308 GLTSCR1 BRD4 interacting chromatin remodeling complex associated protein 2 2
MIRT487329 SREBF1 sterol regulatory element binding transcription factor 1 2 4
MIRT487410 CACNB1 calcium voltage-gated channel auxiliary subunit beta 1 2 2
MIRT487607 C20orf96 chromosome 20 open reading frame 96 2 2
MIRT487689 CDK14 cyclin dependent kinase 14 2 2
MIRT487787 GPR20 G protein-coupled receptor 20 2 4
MIRT488026 ADO 2-aminoethanethiol dioxygenase 2 2
MIRT488476 B3GALNT2 beta-1,3-N-acetylgalactosaminyltransferase 2 2 2
MIRT488761 FXYD1 FXYD domain containing ion transport regulator 1 2 2
MIRT489161 MRPL12 mitochondrial ribosomal protein L12 2 4
MIRT489529 MRE11A MRE11 homolog, double strand break repair nuclease 2 8
MIRT489774 GRINA glutamate ionotropic receptor NMDA type subunit associated protein 1 2 2
MIRT489878 MPLKIP M-phase specific PLK1 interacting protein 2 2
MIRT490094 FN3K fructosamine 3 kinase 2 2
MIRT490202 PKNOX2 PBX/knotted 1 homeobox 2 2 2
MIRT490283 ISL2 ISL LIM homeobox 2 2 2
MIRT490377 LHFPL3 LHFPL tetraspan subfamily member 3 2 2
MIRT491035 ALPK3 alpha kinase 3 2 2
MIRT491186 JUND JunD proto-oncogene, AP-1 transcription factor subunit 2 4
MIRT491766 ZNF385A zinc finger protein 385A 2 2
MIRT491888 YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon 2 2
MIRT491981 UNK unkempt family zinc finger 2 2
MIRT492400 SDK1 sidekick cell adhesion molecule 1 2 2
MIRT493647 HDLBP high density lipoprotein binding protein 2 2
MIRT494010 DUSP9 dual specificity phosphatase 9 2 2
MIRT494167 CNOT6L CCR4-NOT transcription complex subunit 6 like 2 2
MIRT495712 PADI1 peptidyl arginine deiminase 1 2 2
MIRT496873 AHCYL2 adenosylhomocysteinase like 2 2 2
MIRT499175 RBPJL recombination signal binding protein for immunoglobulin kappa J region like 2 2
MIRT501652 PHLDA3 pleckstrin homology like domain family A member 3 2 2
MIRT506645 MAPK1 mitogen-activated protein kinase 1 2 4
MIRT510590 TUBB2A tubulin beta 2A class IIa 2 6
MIRT511907 FKBP1A FK506 binding protein 1A 2 2
MIRT513063 ANKRD45 ankyrin repeat domain 45 2 2
MIRT513104 DYNAP dynactin associated protein 2 2
MIRT521804 POM121C POM121 transmembrane nucleoporin C 2 2
MIRT523520 GLUL glutamate-ammonia ligase 2 2
MIRT525085 FRK fyn related Src family tyrosine kinase 2 2
MIRT530930 SCIN scinderin 2 2
MIRT533501 TRIM71 tripartite motif containing 71 2 2
MIRT538560 CECR2 CECR2, histone acetyl-lysine reader 2 2
MIRT544556 CSNK2A1 casein kinase 2 alpha 1 2 2
MIRT555912 ORMDL3 ORMDL sphingolipid biosynthesis regulator 3 2 2
MIRT560405 TMEM69 transmembrane protein 69 2 2
MIRT560664 RTN3 reticulon 3 2 2
MIRT564061 CDT1 chromatin licensing and DNA replication factor 1 2 2
MIRT565504 SP1 Sp1 transcription factor 2 2
MIRT570014 COL1A2 collagen type I alpha 2 chain 2 2
MIRT572321 HSPB6 heat shock protein family B (small) member 6 2 2
MIRT573229 TRIM21 tripartite motif containing 21 2 2
MIRT573487 IQSEC3 IQ motif and Sec7 domain 3 2 2
MIRT574137 MARVELD1 MARVEL domain containing 1 2 2
MIRT574323 ZNF703 zinc finger protein 703 2 2
MIRT620939 OSMR oncostatin M receptor 2 2
MIRT650080 MTL5 testis expressed metallothionein like protein 2 2
MIRT684553 ZNF708 zinc finger protein 708 2 2
MIRT685841 ANGEL1 angel homolog 1 2 2
MIRT688551 DCAF16 DDB1 and CUL4 associated factor 16 2 2
MIRT701985 MIER3 MIER family member 3 2 2
MIRT703899 EPT1 selenoprotein I 2 2
MIRT706388 MC2R melanocortin 2 receptor 2 2
MIRT707487 UGT2B4 UDP glucuronosyltransferase family 2 member B4 2 2
MIRT711885 INSIG2 insulin induced gene 2 2 2
MIRT719164 KIF6 kinesin family member 6 2 2
MIRT721294 C3orf36 chromosome 3 open reading frame 36 2 2
MIRT721775 ARL6IP4 ADP ribosylation factor like GTPase 6 interacting protein 4 2 2
MIRT723763 NKIRAS2 NFKB inhibitor interacting Ras like 2 2 2
MIRT725485 GPR26 G protein-coupled receptor 26 2 2
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-4 Dexamethasone approved 5743 Microarray primary rat thymocytes 20847043 2010 up-regulated
miR-4271 5-Fluorouracil approved 3385 Microarray CNE cells 22614822 2012 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-4271 Cisplatin 5460033 NSC119875 approved sensitive High Gastric Cancer cell line (BGC823)
hsa-miR-4271 Platinum-based doublet chemotherapy sensitive High Lung Adenocarcinoma tissue
hsa-miR-4271 Platinum 23939 sensitive High Ovarian Cancer tissue
hsa-miR-4271 Fluorouracil 3385 NSC19893 approved sensitive High Pancreatic Cancer cell line (PATU8988)
hsa-miR-4271 Cisplatin 5460033 NSC119875 approved resistant Low Tongue Squamous Cell Carcinoma cell line (CAL-27, SCC-9)
hsa-miR-4271 Paclitaxel 36314 NSC125973 approved resistant High Non-Small Cell Lung Cancer cell line (H460)
hsa-miR-4271 Anlotinib 25017411 NSC832523 sensitive Low Non-Small Cell Lung Cancer cell line (A549, PDC, H460)
hsa-miR-4271 Gefitinib 123631 NSC715055 approved sensitive Low Non-Small Cell Lung Cancer cell line (A549, PDC, H460)
hsa-miR-4271 Icotinib 22024915 NSC800770 sensitive Low Non-Small Cell Lung Cancer cell line (A549, PDC, H460)
hsa-miR-4271 Erlotinib 176870 NSC718781 approved sensitive Low Non-Small Cell Lung Cancer cell line (A549, PDC, H460)
hsa-mir-4271 Cisplatin 5460033 NSC119875 approved resistant cell line (W1)
hsa-mir-4271 Cisplatin 5460033 NSC119875 approved sensitive cell line (A2780)
hsa-mir-4271 Androstenedione+Anastrozole resistant cell line (MCF-7)
hsa-mir-4271 Androstenedione+Letrozole resistant cell line (MCF-7)
hsa-mir-4271 Cisplatin 5460033 NSC119875 approved resistant cell line (BxPC3)
hsa-mir-4271 Cisplatin 5460033 NSC119875 approved sensitive cell line (BGC-823)
hsa-miR-4271 Cisplatin 5460033 NSC119875 approved resistant cell line (CAL-27) (cytosolic RNA)
hsa-miR-4271 Cisplatin 5460033 NSC119875 approved resistant cell line (CAL-27) (total RNA)
hsa-miR-4271 Osimertinib 71496458 NSC779217 approved resistant cell line (H1975)
hsa-miR-4271 Platinum-based doublet chemotherapy sensitive tissue (lung adenocarcinoma)
hsa-miR-4271 Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-4271 Vemurafenib 42611257 NSC761431 approved sensitive cell line (LM16)
hsa-miR-4271 Gemcitabine 60750 NSC613327 approved resistant cell line (PANC-1) (1500 ng/ml)
hsa-miR-4271 Gemcitabine 60750 NSC613327 approved resistant cell line (PANC-1) (100 ng/ml)
hsa-miR-4271 Paclitaxel/Docetaxel/Vinorelbine/Doxorubicin/Etoposide resistant cell line (Bads-200)

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