miRTarBase - #MIRT451850


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pre-miRNA Information
pre-miRNA hsa-mir-216b   
Genomic Coordinates chr2: 56000714 - 56000795
Description Homo sapiens miR-216b stem-loop
Comment This sequence was identified as a miRNA candidate by Berezikov et al. using RAKE and MPSS techniques .
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-216b-3p
Sequence 49| ACACACUUACCCGUAGAGAUUCUA |72
Evidence Experimental
Experiments Illumina
Editing Events in miRNAs
Modification Type Position on miR Chromosome DNA Strand Genomic Position (hg38) List of PMIDs Variant details
A-to-I 9 2 - 56000739 29233923 MiREDiBase
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1032185572 4 dbSNP
rs1291886633 6 dbSNP
rs1195180466 10 dbSNP
rs761473579 10 dbSNP
rs751204276 12 dbSNP
rs368125248 13 dbSNP
rs755646560 13 dbSNP
rs1307586870 14 dbSNP
rs907200088 16 dbSNP
rs763696104 22 dbSNP
rs762699560 24 dbSNP
Putative Targets

miRNA Expression profile
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Biomarker Information
Biomarker ID Name Type Discovered From Mode Level Source Testing Methods
B5PHM2 miR-216b Safety Biomarker (SAF) Clinical/Experimental Data Expression Increase Plasma MiRNA qPCR analyses
Gene Information
Gene Symbol TXNDC5   
Synonyms ENDOPDI, ERP46, HCC-2, HCC2, PDIA15, STRF8, UNQ364
Description thioredoxin domain containing 5
Transcript NM_001145549   
Other Transcripts NM_030810   
Expression
Putative miRNA Targets on TXNDC5
3'UTR of TXNDC5
(miRNA target sites are highlighted)		 
>TXNDC5|NM_001145549|3'UTR
   1 GAACACAGTTGGAGGTCACCTCTCCTGCCCAGCTCCCGCACCCTGCGTTTAGGAGTTCAGTCCCACAGAGGCCACTGGGT
  81 TCCCAGTGGTGGCTGTTCAGAAAGCAGAACATACTAAGCGTGAGGTATCTTCTTTGTGTGTGTGTTTTCCAAGCCAACAC
 161 ACTCTACAGATTCTTTATTAAGTTAAGTTTCTCTAAGTAAATGTGTAACTCATGGTCACTGTGTAAACATTTTCAGTGGC
 241 GATATATCCCCTTTGACCTTCTCTTGATGAAATTTACATGGTTTCCTTTGAGACTAAAATAGCGTTGAGGGAAATGAAAT
 321 TGCTGGACTATTTGTGGCTCCTGAGTTGAGTGATTTTGGTGAAAGAAAGCACATCCAAAGCATAGTTTACCTGCCCACGA
 401 GTTCTGGAAAGGTGGCCTTGTGGCAGTATTGACGTTCCTCTGATCTTAAGGTCACAGTTGACTCAATACTGTGTTGGTCC
 481 GTAGCATGGAGCAGATTGAAATGCAAAAACCCACACCTCTGGAAGATACCTTCACGGCCGCTGCTGGAGCTTCTGTTGCT
 561 GTGAATACTTCTCTCAGTGTGAGAGGTTAGCCGTGATGAAAGCAGCGTTACTTCTGACCGTGCCTGAGTAAGAGAATGCT
 641 GATGCCATAACTTTATGTGTCGATACTTGTCAAATCAGTTACTGTTCAGGGGATCCTTCTGTTTCTCACGGGGTGAAACA
 721 TGTCTTTAGTTCCTCATGTTAACACGAAGCCAGAGCCCACATGAACTGTTGGATGTCTTCCTTAGAAAGGGTAGGCATGG
 801 AAAATTCCACGAGGCTCATTCTCAGTATCTCATTAACTCATTGAAAGATTCCAGTTGTATTTGTCACCTGGGGTGACAAG
 881 ACCAGACAGGCTTTCCCAGGCCTGGGTATCCAGGGAGGCTCTGCAGCCCTGCTGAAGGGCCCTAACTAGAGTTCTAGAGT
 961 TTCTGATTCTGTTTCTCAGTAGTCCTTTTAGAGGCTTGCTATACTTGGTCTGCTTCAAGGAGGTCGACCTTCTAATGTAT
1041 GAAGAATGGGATGCATTTGATCTCAAGACCAAAGACAGATGTCAGTGGGCTGCTCTGGCCCTGGTGTGCACGGCTGTGGC
1121 AGCTGTTGATGCCAGTGTCCTCTAACTCATGCTGTCCTTGTGATTAAACACCTCTATCTCCCTTGGGAATAAGCACATAC
1201 AGGCTTAAGCTCTAAGATAGATAGGTGTTTGTCCTTTTACCATCGAGCTACTTCCCATAATAACCACTTTGCATCCAACA
1281 CTCTTCACCCACCTCCCATACGCAAGGGGATGTGGATACTTGGCCCAAAGTAACTGGTGGTAGGAATCTTAGAAACAAGA
1361 CCACTTATACTGTCTGTCTGAGGCAGAAGATAACAGCAGCATCTCGACCAGCCTCTGCCTTAAAGGAAATCTTTATTAAT
1441 CACGTATGGTTCACAGATAATTCTTTTTTTAAAAAAACCCAACCTCCTAGAGAAGCACAACTGTCAAGAGTCTTGTACAC
1521 ACAACTTCAGCTTTGCATCACGAGTCTTGTATTCCAAGAAAATCAAAGTGGTACAATTTGTTTGTTTACACTATGATACT
1601 TTCTAAATAAACTCTTTTTTTTTAAAAGTCAAAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' aucUUAGAGAUGCCCAUUCACACa 5'
             |:|:||| :  |||| |||| 
Target 5' ttaAGTTTCTCTAAGTAAATGTGt 3'
 183 - 206 137.00 -15.80
2 
miRNA  3' aucUUAGAGAUGC---CCAUUCACAca 5'
             || ||||| |   | ||:||||  
Target 5' cttAAGCTCTAAGATAGATAGGTGTtt 3'
 1204 - 1230 133.00 -9.40
3 
miRNA  3' auCUUA--GAGAUGCCCAUUCACACa 5'
            ||||  :||| |   | |||||| 
Target 5' gtGAATACTTCT-C---TCAGTGTGa 3'
 561 - 582 124.00 -8.70
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN31577950 6 COSMIC
COSN30457179 38 COSMIC
COSN30102934 44 COSMIC
COSN26967909 47 COSMIC
COSN2505575 48 COSMIC
COSN30467690 52 COSMIC
COSN30469318 58 COSMIC
COSN30497144 61 COSMIC
COSN30484171 63 COSMIC
COSN30528575 72 COSMIC
COSN30449015 73 COSMIC
COSN27847494 133 COSMIC
COSN18720510 151 COSMIC
COSN5091386 228 COSMIC
COSN15456680 424 COSMIC
COSN31962565 593 COSMIC
COSN31606871 964 COSMIC
COSN26563211 969 COSMIC
COSN31582767 975 COSMIC
COSN8514780 1012 COSMIC
COSN28666878 1026 COSMIC
COSN24156948 1088 COSMIC
COSN30543499 1095 COSMIC
COSN31518183 1135 COSMIC
COSN31534132 1182 COSMIC
COSN20102371 1215 COSMIC
COSN28640562 1255 COSMIC
COSN28160277 1285 COSMIC
COSN7898739 1296 COSMIC
COSN30053829 1439 COSMIC
COSN31526776 1614 COSMIC
COSN20500128 1623 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs765165338 2 dbSNP
rs778704840 9 dbSNP
rs1309967122 11 dbSNP
rs200743863 13 dbSNP
rs745628771 14 dbSNP
rs969711118 15 dbSNP
rs563361745 20 dbSNP
rs757105073 25 dbSNP
rs749259918 27 dbSNP
rs777744119 28 dbSNP
rs1490659800 35 dbSNP
rs373388814 37 dbSNP
rs1220436508 38 dbSNP
rs1355866669 39 dbSNP
rs1254142681 40 dbSNP
rs1425840593 41 dbSNP
rs368907925 42 dbSNP
rs780867683 42 dbSNP
rs1280404989 43 dbSNP
rs374749063 45 dbSNP
rs372103288 46 dbSNP
rs987483214 47 dbSNP
rs1036059451 56 dbSNP
rs1371752491 56 dbSNP
rs192509951 62 dbSNP
rs890607499 78 dbSNP
rs1397327410 80 dbSNP
rs1406101453 81 dbSNP
rs1319482176 85 dbSNP
rs1362515193 95 dbSNP
rs753763395 96 dbSNP
rs759400006 98 dbSNP
rs1298022754 104 dbSNP
rs530300937 105 dbSNP
rs559272939 113 dbSNP
rs1230956884 114 dbSNP
rs968950944 114 dbSNP
rs1201051665 118 dbSNP
rs751062028 119 dbSNP
rs988543476 120 dbSNP
rs777552387 125 dbSNP
rs1433176231 132 dbSNP
rs148798713 135 dbSNP
rs1174578246 136 dbSNP
rs1319249542 146 dbSNP
rs926190584 146 dbSNP
rs932219046 146 dbSNP
rs1386049048 149 dbSNP
rs1427662864 153 dbSNP
rs1321045221 155 dbSNP
rs1366641207 158 dbSNP
rs1035297182 161 dbSNP
rs1384798864 163 dbSNP
rs540872930 165 dbSNP
rs1312654097 166 dbSNP
rs1234098617 173 dbSNP
rs1267555092 176 dbSNP
rs1327406897 177 dbSNP
rs1210810781 179 dbSNP
rs1470697455 180 dbSNP
rs1248803448 181 dbSNP
rs147425159 182 dbSNP
rs1189789742 185 dbSNP
rs1270129505 187 dbSNP
rs202243956 190 dbSNP
rs913263575 190 dbSNP
rs992883043 193 dbSNP
rs1458548406 199 dbSNP
rs1348882932 201 dbSNP
rs1456220487 201 dbSNP
rs554548444 201 dbSNP
rs751637756 202 dbSNP
rs1368271441 206 dbSNP
rs1409117255 211 dbSNP
rs1287878151 215 dbSNP
rs200153798 217 dbSNP
rs1203312469 227 dbSNP
rs927779758 235 dbSNP
rs1321301714 239 dbSNP
rs995744940 240 dbSNP
rs981019478 241 dbSNP
rs896947709 245 dbSNP
rs11541846 251 dbSNP
rs1491240582 252 dbSNP
rs1491553360 253 dbSNP
rs564845338 254 dbSNP
rs1027980685 255 dbSNP
rs1412660979 259 dbSNP
rs1166722991 266 dbSNP
rs563783394 266 dbSNP
rs1350240703 269 dbSNP
rs940757430 271 dbSNP
rs1014564426 277 dbSNP
rs1372274774 279 dbSNP
rs1280176722 280 dbSNP
rs545755988 282 dbSNP
rs1226807976 290 dbSNP
rs1315352438 294 dbSNP
rs1277715894 297 dbSNP
rs536912595 299 dbSNP
rs1360621072 300 dbSNP
rs112273125 303 dbSNP
rs8643 304 dbSNP
rs1484301026 312 dbSNP
rs1205304456 314 dbSNP
rs996746209 317 dbSNP
rs1335428008 334 dbSNP
rs904713500 342 dbSNP
rs765594405 347 dbSNP
rs557351718 348 dbSNP
rs1390431020 361 dbSNP
rs1413989741 362 dbSNP
rs377347877 366 dbSNP
rs1318559379 370 dbSNP
rs978967941 372 dbSNP
rs541940577 380 dbSNP
rs1430303496 382 dbSNP
rs891776753 387 dbSNP
rs574919872 395 dbSNP
rs1358645942 398 dbSNP
rs1407645981 399 dbSNP
rs1304821999 401 dbSNP
rs1383739188 410 dbSNP
rs1157348190 416 dbSNP
rs1228173102 422 dbSNP
rs913369083 429 dbSNP
rs1295820916 431 dbSNP
rs776463103 433 dbSNP
rs187157283 434 dbSNP
rs1277389591 437 dbSNP
rs1440203422 438 dbSNP
rs959800373 440 dbSNP
rs1211552305 451 dbSNP
rs1243405429 455 dbSNP
rs1464135853 456 dbSNP
rs1183118649 457 dbSNP
rs928418489 464 dbSNP
rs938745541 469 dbSNP
rs979731897 471 dbSNP
rs535238557 480 dbSNP
rs571120732 481 dbSNP
rs1026611226 487 dbSNP
rs769254895 488 dbSNP
rs867612134 490 dbSNP
rs995402156 501 dbSNP
rs1178277193 504 dbSNP
rs1407165802 504 dbSNP
rs761331592 510 dbSNP
rs961604844 513 dbSNP
rs1015405331 515 dbSNP
rs1446216526 524 dbSNP
rs1274793864 526 dbSNP
rs1296882327 526 dbSNP
rs973272402 529 dbSNP
rs1008506107 533 dbSNP
rs961940676 535 dbSNP
rs775084189 536 dbSNP
rs1051889194 539 dbSNP
rs996263741 540 dbSNP
rs900468269 541 dbSNP
rs1360130004 545 dbSNP
rs987535047 551 dbSNP
rs1243222554 552 dbSNP
rs954442056 554 dbSNP
rs1043090483 569 dbSNP
rs1029142249 576 dbSNP
rs1430060803 577 dbSNP
rs1456978427 577 dbSNP
rs1157229798 578 dbSNP
rs995969908 579 dbSNP
rs904660066 584 dbSNP
rs749993468 586 dbSNP
rs1366728771 591 dbSNP
rs1401678494 592 dbSNP
rs568880503 593 dbSNP
rs771714345 600 dbSNP
rs947638761 606 dbSNP
rs1349339559 607 dbSNP
rs1225978548 614 dbSNP
rs373039433 618 dbSNP
rs913499602 619 dbSNP
rs1053279997 620 dbSNP
rs1057414583 622 dbSNP
rs746980547 623 dbSNP
rs370179919 625 dbSNP
rs1366780227 631 dbSNP
rs1163502430 634 dbSNP
rs1200060645 634 dbSNP
rs1180048245 636 dbSNP
rs1442869459 636 dbSNP
rs1365799865 638 dbSNP
rs928387616 642 dbSNP
rs1187360144 643 dbSNP
rs374697218 645 dbSNP
rs559308544 647 dbSNP
rs1223541074 648 dbSNP
rs1407490201 649 dbSNP
rs1289648455 653 dbSNP
rs1490450460 655 dbSNP
rs181032688 655 dbSNP
rs1291018142 657 dbSNP
rs1358210257 657 dbSNP
rs974165368 659 dbSNP
rs1222883278 661 dbSNP
rs552268749 661 dbSNP
rs1295634592 662 dbSNP
rs777615307 662 dbSNP
rs756028998 663 dbSNP
rs1203165252 664 dbSNP
rs557736326 666 dbSNP
rs920390817 674 dbSNP
rs1359494870 677 dbSNP
rs1187112116 689 dbSNP
rs1438673254 689 dbSNP
rs1366877602 692 dbSNP
rs1446844022 696 dbSNP
rs569529930 697 dbSNP
rs1390146592 709 dbSNP
rs940564049 718 dbSNP
rs955151401 721 dbSNP
rs1396588574 722 dbSNP
rs907795065 728 dbSNP
rs1028165898 730 dbSNP
rs1341844408 732 dbSNP
rs987430276 734 dbSNP
rs1296564685 735 dbSNP
rs1340035850 737 dbSNP
rs1230512257 740 dbSNP
rs548204194 745 dbSNP
rs996232709 746 dbSNP
rs1254370961 750 dbSNP
rs1462799200 754 dbSNP
rs1423244882 755 dbSNP
rs775574531 756 dbSNP
rs974873692 763 dbSNP
rs113801312 764 dbSNP
rs1171283333 766 dbSNP
rs772058878 769 dbSNP
rs900604301 770 dbSNP
rs1465131113 771 dbSNP
rs559540684 771 dbSNP
rs1407902927 773 dbSNP
rs1452893873 779 dbSNP
rs1409416222 780 dbSNP
rs1417716961 782 dbSNP
rs1043042023 786 dbSNP
rs1021766889 791 dbSNP
rs142929565 793 dbSNP
rs956229368 801 dbSNP
rs746016998 805 dbSNP
rs1480650266 808 dbSNP
rs139862835 810 dbSNP
rs547149119 811 dbSNP
rs1254309920 821 dbSNP
rs377716853 827 dbSNP
rs1251796575 829 dbSNP
rs1204542529 838 dbSNP
rs532188939 841 dbSNP
rs778691072 841 dbSNP
rs753542991 845 dbSNP
rs1188606017 849 dbSNP
rs1263088646 851 dbSNP
rs938942387 852 dbSNP
rs1196197267 857 dbSNP
rs1430777118 858 dbSNP
rs1469804808 859 dbSNP
rs1003153629 863 dbSNP
rs76441262 868 dbSNP
rs1324753240 876 dbSNP
rs1289198110 877 dbSNP
rs1282984201 878 dbSNP
rs1062680 879 dbSNP
rs1403469333 894 dbSNP
rs1044407935 896 dbSNP
rs995965152 901 dbSNP
rs1347475327 912 dbSNP
rs898579732 916 dbSNP
rs750607635 919 dbSNP
rs1327296030 929 dbSNP
rs1218437765 931 dbSNP
rs948450654 931 dbSNP
rs919701908 933 dbSNP
rs1208579913 934 dbSNP
rs907742967 937 dbSNP
rs973755870 938 dbSNP
rs1352776995 940 dbSNP
rs1052089072 948 dbSNP
rs1180773657 951 dbSNP
rs543289092 954 dbSNP
rs1178860756 955 dbSNP
rs1470404156 957 dbSNP
rs150837271 962 dbSNP
rs1456137494 965 dbSNP
rs563525344 967 dbSNP
rs974442907 969 dbSNP
rs1366064284 984 dbSNP
rs1405663933 985 dbSNP
rs1038835996 990 dbSNP
rs914319199 991 dbSNP
rs1307888244 998 dbSNP
rs762135491 998 dbSNP
rs542257315 999 dbSNP
rs1321506788 1001 dbSNP
rs956178499 1005 dbSNP
rs1479380616 1006 dbSNP
rs1035874683 1009 dbSNP
rs1294624214 1011 dbSNP
rs1244399588 1015 dbSNP
rs1003499128 1021 dbSNP
rs1203875414 1022 dbSNP
rs574795729 1025 dbSNP
rs553516053 1026 dbSNP
rs1260830377 1033 dbSNP
rs975266222 1035 dbSNP
rs1412550539 1038 dbSNP
rs964778397 1043 dbSNP
rs567048562 1044 dbSNP
rs1011577139 1049 dbSNP
rs898525660 1051 dbSNP
rs1307566293 1053 dbSNP
rs1352839469 1058 dbSNP
rs891754894 1063 dbSNP
rs1378590813 1064 dbSNP
rs1223655665 1072 dbSNP
rs188067697 1074 dbSNP
rs1007359346 1075 dbSNP
rs1360543593 1076 dbSNP
rs1003051290 1077 dbSNP
rs1228130067 1082 dbSNP
rs764567114 1084 dbSNP
rs1271408592 1085 dbSNP
rs1204834841 1089 dbSNP
rs577534909 1096 dbSNP
rs1338730556 1098 dbSNP
rs907484310 1107 dbSNP
rs866934597 1109 dbSNP
rs559224887 1111 dbSNP
rs933198961 1112 dbSNP
rs761197070 1118 dbSNP
rs1166473835 1119 dbSNP
rs1421456068 1128 dbSNP
rs1411838533 1140 dbSNP
rs921863848 1144 dbSNP
rs890287192 1147 dbSNP
rs1358600427 1148 dbSNP
rs948922569 1149 dbSNP
rs1339192470 1150 dbSNP
rs898240677 1156 dbSNP
rs1455207941 1159 dbSNP
rs1384177383 1163 dbSNP
rs914266973 1164 dbSNP
rs7764128 1172 dbSNP
rs1364570895 1176 dbSNP
rs570373103 1176 dbSNP
rs767088275 1178 dbSNP
rs1320721380 1180 dbSNP
rs1205018357 1184 dbSNP
rs955778909 1186 dbSNP
rs1464371783 1193 dbSNP
rs554220181 1197 dbSNP
rs1190987624 1204 dbSNP
rs928763725 1209 dbSNP
rs536253196 1214 dbSNP
rs565603569 1215 dbSNP
rs1187274149 1217 dbSNP
rs201545469 1221 dbSNP
rs1460479374 1222 dbSNP
rs970672770 1223 dbSNP
rs1023198340 1224 dbSNP
rs1015568569 1225 dbSNP
rs34795283 1225 dbSNP
rs59341852 1225 dbSNP
rs750210640 1225 dbSNP
rs962657390 1225 dbSNP
rs1206464703 1227 dbSNP
rs778300704 1231 dbSNP
rs554247178 1233 dbSNP
rs986481408 1233 dbSNP
rs1273807701 1239 dbSNP
rs1261641884 1241 dbSNP
rs1343245254 1243 dbSNP
rs1283337647 1244 dbSNP
rs1327904094 1245 dbSNP
rs1203261718 1251 dbSNP
rs933876904 1257 dbSNP
rs1447297209 1262 dbSNP
rs1220552110 1269 dbSNP
rs1352219044 1272 dbSNP
rs759530828 1286 dbSNP
rs921209924 1289 dbSNP
rs975237999 1290 dbSNP
rs1201913260 1292 dbSNP
rs1004212177 1298 dbSNP
rs1469710080 1299 dbSNP
rs1157278963 1300 dbSNP
rs547110108 1301 dbSNP
rs1022133212 1302 dbSNP
rs891216943 1305 dbSNP
rs990608594 1306 dbSNP
rs901318881 1309 dbSNP
rs1303404474 1311 dbSNP
rs1349274915 1316 dbSNP
rs900356752 1323 dbSNP
rs1280850634 1325 dbSNP
rs1038956464 1329 dbSNP
rs947299492 1330 dbSNP
rs758950048 1335 dbSNP
rs1288119325 1336 dbSNP
rs1289282874 1337 dbSNP
rs1490787882 1339 dbSNP
rs892781741 1342 dbSNP
rs368795961 1346 dbSNP
rs1224942801 1353 dbSNP
rs75092157 1356 dbSNP
rs1437241161 1357 dbSNP
rs1179741033 1360 dbSNP
rs544890940 1361 dbSNP
rs1164113721 1366 dbSNP
rs774471884 1367 dbSNP
rs770488987 1368 dbSNP
rs1023211716 1373 dbSNP
rs1013124054 1374 dbSNP
rs1163753496 1381 dbSNP
rs898625649 1383 dbSNP
rs1389376955 1386 dbSNP
rs928401940 1390 dbSNP
rs1038545582 1391 dbSNP
rs981622782 1393 dbSNP
rs368098281 1395 dbSNP
rs1312858440 1396 dbSNP
rs1361259285 1396 dbSNP
rs571092452 1397 dbSNP
rs886884546 1401 dbSNP
rs1186345997 1405 dbSNP
rs1050735299 1406 dbSNP
rs933679330 1414 dbSNP
rs1194336486 1415 dbSNP
rs549603817 1426 dbSNP
rs916080150 1435 dbSNP
rs974275063 1443 dbSNP
rs531505619 1444 dbSNP
rs1043784 1446 dbSNP
rs1164593382 1454 dbSNP
rs1372916667 1455 dbSNP
rs1460125002 1459 dbSNP
rs1169313852 1462 dbSNP
rs1358826076 1463 dbSNP
rs1468843645 1466 dbSNP
rs1051664040 1468 dbSNP
rs946665344 1470 dbSNP
rs1453355499 1471 dbSNP
rs548252162 1471 dbSNP
rs1225458094 1478 dbSNP
rs1324503651 1478 dbSNP
rs867808688 1478 dbSNP
rs1253314280 1480 dbSNP
rs1340078244 1484 dbSNP
rs184067041 1486 dbSNP
rs1029725614 1489 dbSNP
rs988010883 1495 dbSNP
rs900304958 1500 dbSNP
rs879244194 1502 dbSNP
rs1261422219 1506 dbSNP
rs1011466644 1508 dbSNP
rs1017466802 1508 dbSNP
rs956301306 1508 dbSNP
rs924749153 1509 dbSNP
rs1407717081 1511 dbSNP
rs200689151 1512 dbSNP
rs201000429 1512 dbSNP
rs199740442 1513 dbSNP
rs1382443092 1515 dbSNP
rs3031019 1515 dbSNP
rs138941954 1525 dbSNP
rs3031020 1525 dbSNP
rs71548169 1525 dbSNP
rs776160154 1526 dbSNP
rs893052316 1526 dbSNP
rs181054259 1531 dbSNP
rs1223184543 1534 dbSNP
rs1303689801 1535 dbSNP
rs1281418258 1539 dbSNP
rs1325793985 1540 dbSNP
rs1204810102 1541 dbSNP
rs188947034 1542 dbSNP
rs561493893 1548 dbSNP
rs544574218 1550 dbSNP
rs1169197142 1553 dbSNP
rs1262934626 1555 dbSNP
rs565470149 1556 dbSNP
rs1490077045 1559 dbSNP
rs1196881365 1566 dbSNP
rs1462025998 1567 dbSNP
rs1480487397 1570 dbSNP
rs1158205002 1571 dbSNP
rs879772311 1576 dbSNP
rs1455337931 1584 dbSNP
rs564950670 1588 dbSNP
rs1477054760 1591 dbSNP
rs1404526241 1593 dbSNP
rs963010726 1594 dbSNP
rs1017500918 1597 dbSNP
rs1200822454 1599 dbSNP
rs1347407495 1602 dbSNP
rs1219890931 1603 dbSNP
rs1315640586 1607 dbSNP
rs948495919 1612 dbSNP
rs543997553 1613 dbSNP
rs200877924 1614 dbSNP
rs148064346 1616 dbSNP
rs916043781 1618 dbSNP
rs576618139 1622 dbSNP
rs41302895 1623 dbSNP
rs535844593 1624 dbSNP
rs548593250 1624 dbSNP
rs908794350 1624 dbSNP
rs955388194 1624 dbSNP
rs983017080 1624 dbSNP
rs1039401782 1625 dbSNP
rs1367674892 1628 dbSNP
rs201060827 1628 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions TZM-bl
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM1462574. RNA binding protein: AGO2. Condition:TZM-bl ami BaL ...

- Whisnant AW; Bogerd HP; Flores O; Ho P; et al., 2013, mBio.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' aucuuagagaugcccauucACACa 5'
                             |||| 
Target 5' cugcuggagcuucuguugcUGUGa 3'
 		4 - 27
Article - Whisnant AW; Bogerd HP; Flores O; Ho P; et al.
- mBio, 2013
UNLABELLED: The question of how HIV-1 interfaces with cellular microRNA (miRNA) biogenesis and effector mechanisms has been highly controversial. Here, we first used deep sequencing of small RNAs present in two different infected cell lines (TZM-bl and C8166) and two types of primary human cells (CD4(+) peripheral blood mononuclear cells [PBMCs] and macrophages) to unequivocally demonstrate that HIV-1 does not encode any viral miRNAs. Perhaps surprisingly, we also observed that infection of T cells by HIV-1 has only a modest effect on the expression of cellular miRNAs at early times after infection. Comprehensive analysis of miRNA binding to the HIV-1 genome using the photoactivatable ribonucleoside-induced cross-linking and immunoprecipitation (PAR-CLIP) technique revealed several binding sites for cellular miRNAs, a subset of which were shown to be capable of mediating miRNA-mediated repression of gene expression. However, the main finding from this analysis is that HIV-1 transcripts are largely refractory to miRNA binding, most probably due to extensive viral RNA secondary structure. Together, these data demonstrate that HIV-1 neither encodes viral miRNAs nor strongly influences cellular miRNA expression, at least early after infection, and imply that HIV-1 transcripts have evolved to avoid inhibition by preexisting cellular miRNAs by adopting extensive RNA secondary structures that occlude most potential miRNA binding sites. IMPORTANCE: MicroRNAs (miRNAs) are a ubiquitous class of small regulatory RNAs that serve as posttranscriptional regulators of gene expression. Previous work has suggested that HIV-1 might subvert the function of the cellular miRNA machinery by expressing viral miRNAs or by dramatically altering the level of cellular miRNA expression. Using very sensitive approaches, we now demonstrate that neither of these ideas is in fact correct. Moreover, HIV-1 transcripts appear to largely avoid regulation by cellular miRNAs by adopting an extensive RNA secondary structure that occludes the ability of cellular miRNAs to interact with viral mRNAs. Together, these data suggest that HIV-1, rather than seeking to control miRNA function in infected cells, has instead evolved a mechanism to become largely invisible to cellular miRNA effector mechanisms.
LinkOut: [PMID: 23592263]
CLIP-seq Support 1 for dataset GSM1462574
Method / RBP PAR-CLIP / AGO2
Cell line / Condition TZM-bl / TZM-bl ami BaL
Location of target site ENST00000539054.1 | 3UTR | CCGCUGCUGGAGCUUCUGUUGCUGUGAAUACUUCUCUCAG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23592263 / GSE59944
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
111 hsa-miR-216b-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT071722 CCNK cyclin K 2 2
MIRT074768 CNEP1R1 CTD nuclear envelope phosphatase 1 regulatory subunit 1 2 2
MIRT101407 SSR1 signal sequence receptor subunit 1 2 2
MIRT241289 AASDHPPT aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 2 4
MIRT268292 CCND1 cyclin D1 2 8
MIRT445347 IFNA6 interferon alpha 6 2 2
MIRT446663 MXI1 MAX interactor 1, dimerization protein 2 4
MIRT447595 MSH3 mutS homolog 3 2 2
MIRT448485 SEMA4F ssemaphorin 4F 2 2
MIRT450309 DRAXIN dorsal inhibitory axon guidance protein 2 2
MIRT451850 TXNDC5 thioredoxin domain containing 5 2 2
MIRT483613 SMC5 structural maintenance of chromosomes 5 2 2
MIRT485633 EEPD1 endonuclease/exonuclease/phosphatase family domain containing 1 2 2
MIRT499766 CIRH1A UTP4, small subunit processome component 2 6
MIRT503337 MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 2 2
MIRT513007 MAN1A2 mannosidase alpha class 1A member 2 2 2
MIRT513529 RHOQ ras homolog family member Q 2 4
MIRT521499 RAB11B RAB11B, member RAS oncogene family 2 2
MIRT524335 CRK CRK proto-oncogene, adaptor protein 2 4
MIRT524731 BRI3BP BRI3 binding protein 2 8
MIRT525326 SNX29 sorting nexin 29 2 2
MIRT526264 CCDC169 coiled-coil domain containing 169 2 2
MIRT527428 NRL neural retina leucine zipper 2 2
MIRT527512 ZNF134 zinc finger protein 134 2 2
MIRT528881 ATF3 activating transcription factor 3 2 2
MIRT529578 IGBP1 immunoglobulin binding protein 1 2 4
MIRT531122 ZYG11B zyg-11 family member B, cell cycle regulator 2 2
MIRT531341 TGIF2LX TGFB induced factor homeobox 2 like, X-linked 2 2
MIRT532433 DHX33 DEAH-box helicase 33 2 2
MIRT534032 STX7 syntaxin 7 2 2
MIRT534538 SACS sacsin molecular chaperone 2 4
MIRT538886 BRWD3 bromodomain and WD repeat domain containing 3 2 2
MIRT539628 CD19 CD19 molecule 2 8
MIRT540327 ATAT1 alpha tubulin acetyltransferase 1 2 8
MIRT540353 OCLN occludin 2 6
MIRT540699 ATG10 autophagy related 10 2 4
MIRT541033 STRBP spermatid perinuclear RNA binding protein 2 8
MIRT541945 NBPF10 NBPF member 10 2 4
MIRT543505 PLS1 plastin 1 2 2
MIRT551164 UBTF upstream binding transcription factor, RNA polymerase I 2 4
MIRT551790 ZNF117 zinc finger protein 117 2 4
MIRT553227 TWF1 twinfilin actin binding protein 1 2 2
MIRT559622 AKIRIN2 akirin 2 2 2
MIRT559719 ADORA2B adenosine A2b receptor 2 2
MIRT564600 ZNF781 zinc finger protein 781 2 2
MIRT567015 KLHL15 kelch like family member 15 2 2
MIRT569564 C7orf26 chromosome 7 open reading frame 26 2 2
MIRT572155 DDX3X DEAD-box helicase 3, X-linked 2 2
MIRT575399 Zdhhc22 zinc finger, DHHC-type containing 22 2 5
MIRT607322 PKNOX1 PBX/knotted 1 homeobox 1 2 4
MIRT607953 NFAM1 NFAT activating protein with ITAM motif 1 2 10
MIRT607979 ZDHHC22 zinc finger DHHC-type containing 22 2 7
MIRT609145 ZNF610 zinc finger protein 610 2 4
MIRT609206 GOSR2 golgi SNAP receptor complex member 2 2 4
MIRT609338 HRASLS5 HRAS like suppressor family member 5 2 2
MIRT609725 KIF5C kinesin family member 5C 2 4
MIRT610014 MED24 mediator complex subunit 24 2 4
MIRT610407 TMEM245 transmembrane protein 245 2 2
MIRT610559 NBPF14 NBPF member 14 2 2
MIRT611291 PAGR1 PAXIP1 associated glutamate rich protein 1 2 2
MIRT611399 ATP9A ATPase phospholipid transporting 9A (putative) 2 2
MIRT611432 C11orf45 chromosome 11 open reading frame 45 2 4
MIRT611710 SLFN13 schlafen family member 13 2 2
MIRT611721 ANK3 ankyrin 3 2 2
MIRT611830 CACNG8 calcium voltage-gated channel auxiliary subunit gamma 8 2 4
MIRT611977 ZNF175 zinc finger protein 175 2 2
MIRT612073 CEP135 centrosomal protein 135 2 4
MIRT612195 CCDC77 coiled-coil domain containing 77 2 2
MIRT612320 UBE2H ubiquitin conjugating enzyme E2 H 2 2
MIRT612354 TNRC6C trinucleotide repeat containing 6C 2 4
MIRT612635 PTEN phosphatase and tensin homolog 2 2
MIRT612773 MLXIP MLX interacting protein 2 4
MIRT612788 MAP3K9 mitogen-activated protein kinase kinase kinase 9 2 4
MIRT612853 JAZF1 JAZF zinc finger 1 2 2
MIRT612965 GID4 GID complex subunit 4 homolog 2 6
MIRT613132 DUSP6 dual specificity phosphatase 6 2 2
MIRT613388 AAK1 AP2 associated kinase 1 2 2
MIRT615058 CRY2 cryptochrome circadian clock 2 2 4
MIRT616046 HSPA12B heat shock protein family A (Hsp70) member 12B 2 2
MIRT617962 SEPT9 septin 9 2 2
MIRT618413 ATP2A2 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 2 2
MIRT622448 RNF213 ring finger protein 213 2 2
MIRT623611 IPCEF1 interaction protein for cytohesin exchange factors 1 2 2
MIRT625709 SHROOM1 shroom family member 1 2 2
MIRT630646 ELK1 ELK1, ETS transcription factor 2 2
MIRT630970 KIAA2022 neurite extension and migration factor 2 2
MIRT631003 SPAG7 sperm associated antigen 7 2 2
MIRT640385 EMC1 ER membrane protein complex subunit 1 2 4
MIRT641064 WBSCR17 polypeptide N-acetylgalactosaminyltransferase 17 2 2
MIRT641780 ZDHHC7 zinc finger DHHC-type containing 7 2 4
MIRT646310 MPHOSPH8 M-phase phosphoprotein 8 2 2
MIRT646624 CENPL centromere protein L 2 2
MIRT659653 CDH2 cadherin 2 2 2
MIRT666161 SP1 Sp1 transcription factor 2 2
MIRT667638 LHFPL2 LHFPL tetraspan subfamily member 2 2 2
MIRT668988 CHRFAM7A CHRNA7 (exons 5-10) and FAM7A (exons A-E) fusion 2 2
MIRT680949 PLCXD1 phosphatidylinositol specific phospholipase C X domain containing 1 2 2
MIRT695238 PBK PDZ binding kinase 2 2
MIRT700036 RPL22 ribosomal protein L22 2 2
MIRT707685 GPR50 G protein-coupled receptor 50 2 2
MIRT709324 HMBOX1 homeobox containing 1 2 2
MIRT710176 MTRF1L mitochondrial translational release factor 1 like 2 2
MIRT712007 F9 coagulation factor IX 2 2
MIRT714219 C10orf71 chromosome 10 open reading frame 71 2 2
MIRT714496 HSPA4 heat shock protein family A (Hsp70) member 4 2 2
MIRT714575 GALNT10 polypeptide N-acetylgalactosaminyltransferase 10 2 2
MIRT715982 TFRC transferrin receptor 2 2
MIRT717870 TRAPPC3L trafficking protein particle complex 3 like 2 2
MIRT718289 MINA ribosomal oxygenase 2 2 2
MIRT725200 PTRF caveolae associated protein 1 2 2
MIRT737338 TPX2 TPX2, microtubule nucleation factor 3 0
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-216b Perfluorooctane sulfonate NULL 74483 Microarray zebrafish embryos 20878907 2011 up-regulated
miR-216b 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) NULL 15625 Microarray embryos 22921993 2012 up-regulated
miR-216b Reversine NULL 210332 Microarray C2C12 myoblast cells 24513286 2014 up-regulated
miR-216b Hydroxycamptothecin (HCPT) NULL 97226 Microarray human Tenon's fibroblasts (HTFs) 24681041 2014 down-regulated
miR-216b Hydroxycamptothecin (HCPT) NULL 97226 Quantitative real-time PCR human Tenon's fibroblasts (HTFs) 24681041 2014 down-regulated
miR-216b Curcumin NULL 969516 Quantitative real-time PCR Y79 RB cells. 22510010 2012 down-regulated
miR-216b Doxorubicin approved 31703 Quantitative real-time PCR heart 22859947 2012 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-216b Paclitaxel 36314 NSC125973 approved sensitive cell line (A2780)
hsa-mir-216b Cisplatin 5460033 NSC119875 approved sensitive cell line (A2780)
hsa-miR-216b-3p Tripterygium wilfordii Hook F resistant tissue
hsa-miR-216b-3p Gefitinib 123631 NSC715055 approved sensitive cell line (HCC827)
hsa-miR-216b-3p Cisplatin 5460033 NSC119875 approved sensitive cell line (MGC-803)

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