miRTarBase - #MIRT452324


—
pre-miRNA Information
pre-miRNA hsa-mir-4728   
Genomic Coordinates chr17: 39726495 - 39726561
Description Homo sapiens miR-4728 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-4728-5p
Sequence 2| UGGGAGGGGAGAGGCAGCAAGCA |24
Evidence Experimental
Experiments Illumina
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1419589985 1 dbSNP
rs778443386 2 dbSNP
rs1275042409 3 dbSNP
rs748675090 6 dbSNP
rs772543431 17 dbSNP
rs773610056 18 dbSNP
rs747372658 21 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
Circulating MicroRNA Expression Profiling
Biomarker Information
Biomarker ID Name Type Discovered From Mode Level Source Testing Methods
BQA97X miR-4728 Predictive Biomarker (PRD) Transcriptomic Data . . . .
Gene Information
Gene Symbol EIF5AL1   
Synonyms EIF5AP1, bA342M3.3
Description eukaryotic translation initiation factor 5A-like 1
Transcript NM_001099692   
Expression
Putative miRNA Targets on EIF5AL1
3'UTR of EIF5AL1
(miRNA target sites are highlighted)		 
>EIF5AL1|NM_001099692|3'UTR
   1 CTGGCTCCCAAGGTGGCAGTGGTGGCAGCAGTGATCCTCCGAACCTGCAGAGGCCCCCTCCCCCAGCCTGGCCTGGCTCT
  81 GGCCTGGTCCTAGGTTGGACTCCTCCTACACAATTTATTTGACGTTTTATTTTGGTTTTCCCCACCCCCTCAATCTGTCA
 161 GGGAGCCCCTGCCCTTCACCTAGCTCCCTTGGCCAGGAGCGAGCGAAGCCATGGCCTTGGTGAAGCTGCCCTCCTCTTCT
 241 CCCCTCACACTACAGCCCTGGTGGGGGAGAAGGGGGTGGGTGCTGCTTGTGGTTTAGTCTTTTTTTTTTTTTTAAATTCA
 321 ATCTGGAATCAGAAAGCGGTGGATTCTGGCAAATGGTCCTTGTGCCCTCCCCACTCATCCTTGGTCTGGTCCCCTGTTGC
 401 CCATAGCCCTTTACCCTGAGCACCACCCAACAGACTGGGGACCAGCCCCCTCGCCTGCCTGTGTCTCTCCCCAAACCCCT
 481 TTAGATGGGGAGGGAAGAAGAGGAGAGGGGAGGGGACCTGCCCCCTCCTCAGGCATCTGGGAAGGGCCTGCCCCCATGGG
 561 CTTTACCCTTCCCTGCGGGCTCTCTCCCCGACACATTTGTTAAAATCAAACCTGAATAAAACTACAAGTTTAATATGAAA
 641 AAAAAAAAAAAAGAAAGAAAGACGTGTAAAATGCCAAGAACTCTAGGAAACAGGGACAAAAACACTTCAAAGAGAAAGTT
 721 CATGCACTTGTTTCTGACCACCCAGGGCACCCTTCAGCACACGCTGTCTGGAGTGGCCTGAAGCAAGGAGTGTCTTGTGA
 801 GGTGCAGAGGATGCAATGGGAGCAGGGTCCTGTCCCCACCCTAAAGGAGTTCACAGTTTAACGCAAATGAGAAGCCAGTG
 881 AGGACATCACTACTCCTGCTGTGAACTTGGGAACTAGAAACACAAAACCTGAGTCTGGAGGGAAGCTAAGGAAGCATTCT
 961 GCTCTGGAGTAGACATGAGTGCGTGTGAAGCTTCTGATCTCCCATGAGAGCAATGGGGACATGGGGCAGAATCTAAAACC
1041 CATGACTGAAAGCACCAAATTGCTAAAATGGCAATAAAGAGACATGAGGCCAAGATGGAGAAGAAGGAACCCAGGACGAG
1121 GGTCAGCCTCACATTTGGGGCTCATTTCCCTCAGTTTCCTCACTGAATTTCAGAAGGGACTAACTGAGATGCAAAGAAGC
1201 AGAGCAGCTTTTGCACCATGTGGAGGACTAGATGGAAAACAAGTAGACTGAGGGTCTGCTAGTGAAGGTGACCCCTACTG
1281 AAGTCCACTGGCTTTGGTTGGGACCCAGAAGAGTCACACGCCAGGAATAGAGGTGGACAGGAAACACCCTGACTTTTGTA
1361 GGGACTGAACCTCACTGATAACCTCAATTGCGGATGGTATGGAGGGTGTCTAGGTGTGCTAGGACCCCTGCCCATTCCCC
1441 AGAAATAGACTCCCATCTTTTCTACAGCAAGATAACGTGCTAGTAGGCCTCAATTCATTGCTAAATATTTTTAACGAGTG
1521 TCTTACATTTAGCCAAAAAGACTAGTCATGTGGCAGGAAAAATACAATGTCATATGACCAAAAGCTAAAAGACTGTGAAA
1601 ATGAATCCAGAGGTGACCCAAGCATTGAATTTAACAATGCCAGTACCTGGACCTCCGCTTGCCCCTAAAACATTACAATC
1681 AAGAATGTAGGAAGGGAAAGGAAACACGAAGATTAATCAAGCAGGAAGGACAAGCTCAGTTTTGCACCCACTGAATTTGC
1761 CACAAATATTGTGGAAAATATTCTCGGGGACATTGCAGTTGTCTACTTTGGTTGGCACATGGTTCATACAACAGTGTTTG
1841 TGTCAGTGAACATCTTACTCTTCCTCGGCAGTCTTTCTTTGCCCAGAGATTTCGCAATGACTGTTGACCTTCATCATCAC
1921 CTTTTGGACTTTGGCTTGCACTTTAGCTTCTGTAGATCTCCATGATGTAAAGAAGTATTTTAGGTCCATTTTAATTCCTG
2001 CAAAGGATAAAATCCTTCTATTTGTGTGCATATAAGTGGACCTGAGCCCTTGGTTAGGGTGTAGAGAGGAGAAGGGGAGA
2081 AACCTGAGGGCCAGAAGCTGTTCTTTCCCTTAAAAGGGCAAACTCATTTCCACACTATGGGGACTCTGACAGATAGCATA
2161 CCTTCCTGTCTATGGCTATTGGACCTGCAGGCTTTCCCCTGTAAATCCGTGTTCTGTCATTGACATTTTGTGACTGTAAG
2241 ACAGACTTGAGATAAGACATCTAGAAAACAATAATTGAACAATGATGTGAATATATTTCACACAACTGAACTGTACATTT
2321 CAACAAGGTTAAGATGGTAATTATCACGTTATACATTTTTTACCGCAGGTTAAAATGTTTCACAGGTTGAAAGGAAAGCA
2401 ACTACCTTCAGTTCTCTGAGTTCAAGAATTTGTAACATTTCACCCCCTGCTCCTTCCTGATCTTCTGTGGAGCATCTTTT
2481 TTCCATCCATGCTCTACTCAGAGCCCACTTTCCCTTCCCTGACACCAGCTTCACTGAGGCTGGTTGGAACCTAACACAAA
2561 ACATTCTCAGTAATGACTGAATTCCCACAAAGAATTCCATATAGACTGCATATGAGTTGAATCTTCTAAGACATGAAATA
2641 TTTGTTCTCTTCTTGGCTAATATGCAATGCAAATCCTGTTGCAGATGTACGTCATATACCTCTGAAATTCCTGATGTATT
2721 CAATGAAATAACATCTTTAAAGTTCTGTGTAGAATGTTTTTTTTCTGATTTCTTCACATACGATAGAAAAAAAAACCCAA
2801 AAAAACATGTACTAGGATTTCAATAGAAGCAATGGGTGATCTAAAAAGATGAAAGAGCAACCGCATGCGCCCTACAGCTA
2881 CCGCTAGATTTTATGGGGAAAGCAGCTGGCCCAGTTTGCAGCTAGGAGAAATGTCAAACACATGAAGAAATGAGAAGCAA
2961 AGAAAAACCATGAGGCATGAACATTTCATGGCAATCACGATGTCCTGGTTTGTGAGATAATGGGATAGAGGAGTAGAAAA
3041 CAAGGAGAAAGATGAGAAGGTACAAAGTGGTTCAAGTCAAACAGCTCAACTGAACTTTTCTTAATGGAATATTTAAAAAG
3121 TGGTACATTAAAAAACTTCCCCCAGTTCACATCAAAAATTCTCTCTTCAGGACTAAGTTGGGTAGAGACTGTTCAATGTG
3201 CCTAGATATCTTCAGAACTTATATATTTTCTGTTTTCTACGTATGTTGAAGGGCAGTGCCAAATGATGTGTAATTATCTA
3281 GGTTGTAAAAATAAAACATACTCCCCCTTCCCTTGAGGATAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' acgaACGACGGAGAGGGGAGGGu 5'
              || | |:| | ||||||| 
Target 5' caaaTGGTCCTTGTGCCCTCCCc 3'
 350 - 372 159.00 -21.30
2 
miRNA  3' acGAAC-GACGGAGA-GGGGAGGGu 5'
            || | |||||| | :|:||||| 
Target 5' ccCTCGCCTGCCTGTGTCTCTCCCc 3'
 448 - 472 153.00 -22.80
3 
miRNA  3' acGAACGACGGAGAGGGGAGGGu 5'
            | ||| |   | |||||||| 
Target 5' aaCCTGCAGAGGC-CCCCTCCCc 3'
 42 - 63 152.00 -21.70
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN15623903 9 COSMIC
COSN19695423 12 COSMIC
COSN28596743 19 COSMIC
COSN30127616 40 COSMIC
COSN28600693 41 COSMIC
COSN30134685 42 COSMIC
COSN30513996 66 COSMIC
COSN30451557 69 COSMIC
COSN31491314 77 COSMIC
COSN30174783 80 COSMIC
COSN30530634 82 COSMIC
COSN15623904 93 COSMIC
COSN30460478 104 COSMIC
COSN26601854 108 COSMIC
COSN31538520 125 COSMIC
COSN23012268 140 COSMIC
COSN31532807 150 COSMIC
COSN28642116 216 COSMIC
COSN15623905 223 COSMIC
COSN24303437 279 COSMIC
COSN31561620 282 COSMIC
COSN19661387 313 COSMIC
COSN8721944 314 COSMIC
COSN17251091 338 COSMIC
COSN8189997 339 COSMIC
COSN31578946 360 COSMIC
COSN31490073 364 COSMIC
COSN26569189 382 COSMIC
COSN31488303 468 COSMIC
COSN31536788 471 COSMIC
COSN31551690 534 COSMIC
COSN31562843 577 COSMIC
COSN31593692 578 COSMIC
COSN20092131 590 COSMIC
COSN16669840 595 COSMIC
COSN28649496 621 COSMIC
COSN31568558 629 COSMIC
COSN23961180 650 COSMIC
COSN28826693 654 COSMIC
COSN26642068 688 COSMIC
COSN26506599 726 COSMIC
COSN30526632 727 COSMIC
COSN15623906 735 COSMIC
COSN30172996 759 COSMIC
COSN16914468 763 COSMIC
COSN30529886 765 COSMIC
COSN30540981 765 COSMIC
COSN24303349 864 COSMIC
COSN8721945 884 COSMIC
COSN28712219 886 COSMIC
COSN30122085 901 COSMIC
COSN26559597 934 COSMIC
COSN23972520 935 COSMIC
COSN30136825 939 COSMIC
COSN30121727 961 COSMIC
COSN15623907 982 COSMIC
COSN26571205 1010 COSMIC
COSN30537294 1011 COSMIC
COSN30545028 1017 COSMIC
COSN30530970 1044 COSMIC
COSN8189998 1045 COSMIC
COSN30133024 1086 COSMIC
COSN15623908 1099 COSMIC
COSN28669077 1118 COSMIC
COSN8640533 1118 COSMIC
COSN32128896 1153 COSMIC
COSN1501705 1193 COSMIC
COSN30130415 1238 COSMIC
COSN30539276 1251 COSMIC
COSN31608411 1321 COSMIC
COSN15623909 1403 COSMIC
COSN15623910 1439 COSMIC
COSN28529472 1465 COSMIC
COSN30114571 1467 COSMIC
COSN30142005 1472 COSMIC
COSN7070026 1497 COSMIC
COSN28740048 1545 COSMIC
COSN8640534 1545 COSMIC
COSN31960506 1579 COSMIC
COSN31537904 1591 COSMIC
COSN30513667 1592 COSMIC
COSN15623911 1604 COSMIC
COSN26678464 1604 COSMIC
COSN15623912 1656 COSMIC
COSN31530990 1675 COSMIC
COSN30120911 1709 COSMIC
COSN31524143 1803 COSMIC
COSN30136578 1838 COSMIC
COSN30117745 1851 COSMIC
COSN15623913 1889 COSMIC
COSN28749126 1894 COSMIC
COSN23012269 1926 COSMIC
COSN31601853 1956 COSMIC
COSN28766006 1969 COSMIC
COSN7070027 1969 COSMIC
COSN31578140 1973 COSMIC
COSN31573234 1984 COSMIC
COSN31576572 1984 COSMIC
COSN15623914 1987 COSMIC
COSN30176963 2014 COSMIC
COSN31530450 2036 COSMIC
COSN30126077 2047 COSMIC
COSN28758990 2141 COSMIC
COSN30539821 2186 COSMIC
COSN26678027 2212 COSMIC
COSN31519684 2252 COSMIC
COSN30111883 2265 COSMIC
COSN6605693 2285 COSMIC
COSN16599748 2348 COSMIC
COSN31594569 2362 COSMIC
COSN31482863 2382 COSMIC
COSN15623915 2394 COSMIC
COSN30112127 2427 COSMIC
COSN5291199 2545 COSMIC
COSN19344901 2574 COSMIC
COSN31609589 2593 COSMIC
COSN4695240 2627 COSMIC
COSN30119567 2670 COSMIC
COSN30137394 2685 COSMIC
COSN30130199 2711 COSMIC
COSN30143061 2752 COSMIC
COSN20107305 2765 COSMIC
COSN28637219 2782 COSMIC
COSN31490466 2782 COSMIC
COSN29467764 2783 COSMIC
COSN1123067 2796 COSMIC
COSN25448511 2796 COSMIC
COSN30128885 2796 COSMIC
COSN15623916 2797 COSMIC
COSN30133155 2801 COSMIC
COSN23012270 2806 COSMIC
COSN5291200 2832 COSMIC
COSN10073304 2856 COSMIC
COSN28823440 2869 COSMIC
COSN30122755 2870 COSMIC
COSN28714293 2874 COSMIC
COSN31570881 2975 COSMIC
COSN28633274 2980 COSMIC
COSN30120012 3000 COSMIC
COSN5884787 3052 COSMIC
COSN15623917 3093 COSMIC
COSN26636962 3146 COSMIC
COSN28533783 3146 COSMIC
COSN30142505 3157 COSMIC
COSN15623918 3162 COSMIC
COSN7070028 3241 COSMIC
COSN31483438 3242 COSMIC
COSN30543386 3256 COSMIC
COSN28776385 3307 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1180105632 5 dbSNP
rs1428754649 6 dbSNP
rs1409566249 8 dbSNP
rs199829110 12 dbSNP
rs774001523 14 dbSNP
rs745741524 15 dbSNP
rs771778567 17 dbSNP
rs1037749236 19 dbSNP
rs776787386 20 dbSNP
rs375383701 24 dbSNP
rs1286693383 26 dbSNP
rs1448172417 29 dbSNP
rs769838158 31 dbSNP
rs1241089952 37 dbSNP
rs1488640720 39 dbSNP
rs530848190 41 dbSNP
rs763440123 42 dbSNP
rs1454191756 46 dbSNP
rs1049562635 48 dbSNP
rs766980301 50 dbSNP
rs1313266371 53 dbSNP
rs1196515331 54 dbSNP
rs1241469786 54 dbSNP
rs551038176 65 dbSNP
rs1389720218 68 dbSNP
rs890984743 68 dbSNP
rs1303680756 69 dbSNP
rs1423829992 71 dbSNP
rs1363498359 75 dbSNP
rs1160164208 86 dbSNP
rs1470327982 94 dbSNP
rs376353382 96 dbSNP
rs1179116137 102 dbSNP
rs1434370034 103 dbSNP
rs1223865317 105 dbSNP
rs561253312 111 dbSNP
rs1290053038 113 dbSNP
rs1207212274 118 dbSNP
rs1351732335 120 dbSNP
rs1467322394 123 dbSNP
rs1237060746 124 dbSNP
rs1347450269 125 dbSNP
rs530285988 143 dbSNP
rs1254058515 146 dbSNP
rs1449285658 147 dbSNP
rs1363598471 149 dbSNP
rs1320074984 154 dbSNP
rs181568144 159 dbSNP
rs891576736 163 dbSNP
rs1011654746 167 dbSNP
rs1467186292 168 dbSNP
rs1021313536 170 dbSNP
rs566778560 176 dbSNP
rs970701228 182 dbSNP
rs1480408029 187 dbSNP
rs1267351525 193 dbSNP
rs1001752271 194 dbSNP
rs1375348555 196 dbSNP
rs1447934665 201 dbSNP
rs1462048584 202 dbSNP
rs1162133523 205 dbSNP
rs2475361 206 dbSNP
rs150231945 212 dbSNP
rs1271825862 213 dbSNP
rs1035795796 215 dbSNP
rs1250784 216 dbSNP
rs1364150396 217 dbSNP
rs1454253292 220 dbSNP
rs568822142 222 dbSNP
rs1175146151 229 dbSNP
rs907950199 232 dbSNP
rs963520912 235 dbSNP
rs561775528 237 dbSNP
rs973800840 241 dbSNP
rs921969159 257 dbSNP
rs1191432322 259 dbSNP
rs1283699541 261 dbSNP
rs537475188 262 dbSNP
rs554622164 264 dbSNP
rs1215104753 268 dbSNP
rs1000618802 269 dbSNP
rs1338596835 270 dbSNP
rs1464720006 274 dbSNP
rs1268233400 275 dbSNP
rs1203825629 277 dbSNP
rs1383121201 278 dbSNP
rs1335663917 279 dbSNP
rs1264389605 286 dbSNP
rs1429640617 295 dbSNP
rs1186164440 298 dbSNP
rs775964081 299 dbSNP
rs1446791556 300 dbSNP
rs201142369 300 dbSNP
rs796392326 300 dbSNP
rs879208936 300 dbSNP
rs932538006 300 dbSNP
rs112497077 301 dbSNP
rs1049677316 310 dbSNP
rs1183211744 314 dbSNP
rs1482368910 314 dbSNP
rs1475923442 315 dbSNP
rs1165163957 317 dbSNP
rs1469375747 320 dbSNP
rs1270757636 322 dbSNP
rs1247979937 338 dbSNP
rs2475362 339 dbSNP
rs147452254 340 dbSNP
rs1290428962 351 dbSNP
rs1052977692 354 dbSNP
rs1279652285 355 dbSNP
rs1030720552 363 dbSNP
rs891521329 364 dbSNP
rs1310541004 370 dbSNP
rs1427010072 371 dbSNP
rs1353620542 380 dbSNP
rs1235278115 392 dbSNP
rs1163266357 397 dbSNP
rs1422320205 402 dbSNP
rs1410381090 405 dbSNP
rs1294134322 412 dbSNP
rs1328762651 416 dbSNP
rs1249596949 418 dbSNP
rs1224640726 424 dbSNP
rs1237261310 448 dbSNP
rs1290798723 451 dbSNP
rs554011621 453 dbSNP
rs1318403468 454 dbSNP
rs1011353590 462 dbSNP
rs1370524280 465 dbSNP
rs1284581833 466 dbSNP
rs1407308653 471 dbSNP
rs1262887394 476 dbSNP
rs1302951293 489 dbSNP
rs1456695703 490 dbSNP
rs1347239937 499 dbSNP
rs1400279250 500 dbSNP
rs190470806 500 dbSNP
rs1043084832 501 dbSNP
rs1256078203 503 dbSNP
rs1201635712 517 dbSNP
rs1480735344 517 dbSNP
rs546109015 518 dbSNP
rs1196375241 521 dbSNP
rs1486356954 522 dbSNP
rs1188128009 529 dbSNP
rs2260836 547 dbSNP
rs1416967498 549 dbSNP
rs1160972579 554 dbSNP
rs575571092 556 dbSNP
rs1465403044 558 dbSNP
rs1326567886 560 dbSNP
rs1300999341 561 dbSNP
rs892314964 569 dbSNP
rs2678616 577 dbSNP
rs1416627830 578 dbSNP
rs1385506621 579 dbSNP
rs544301826 581 dbSNP
rs561398057 583 dbSNP
rs1313572812 584 dbSNP
rs1430316694 587 dbSNP
rs557317826 590 dbSNP
rs540374389 591 dbSNP
rs1389920867 594 dbSNP
rs1470325911 610 dbSNP
rs1428596436 612 dbSNP
rs1309472991 616 dbSNP
rs1013401709 618 dbSNP
rs1250785 621 dbSNP
rs1004990041 625 dbSNP
rs1233052263 632 dbSNP
rs1278804089 635 dbSNP
rs1185677579 636 dbSNP
rs1244577767 637 dbSNP
rs1350684942 637 dbSNP
rs1491572677 637 dbSNP
rs1203802573 638 dbSNP
rs1214327831 638 dbSNP
rs202094598 638 dbSNP
rs757927678 638 dbSNP
rs878866979 638 dbSNP
rs879137185 638 dbSNP
rs1210922420 639 dbSNP
rs1250472370 641 dbSNP
rs1479397060 645 dbSNP
rs1453547785 650 dbSNP
rs1463494805 650 dbSNP
rs532603804 650 dbSNP
rs1373528002 651 dbSNP
rs969739008 654 dbSNP
rs1250867562 656 dbSNP
rs980705091 658 dbSNP
rs1447404691 660 dbSNP
rs1171531034 661 dbSNP
rs1015124147 664 dbSNP
rs1183835542 665 dbSNP
rs1253495882 666 dbSNP
rs1196981062 673 dbSNP
rs76212521 684 dbSNP
rs1174295970 692 dbSNP
rs80290545 693 dbSNP
rs1204977442 722 dbSNP
rs1340465500 723 dbSNP
rs1317543007 726 dbSNP
rs1340055805 731 dbSNP
rs1310695998 736 dbSNP
rs1440176012 743 dbSNP
rs1393194888 744 dbSNP
rs973531760 748 dbSNP
rs921889194 752 dbSNP
rs531305134 763 dbSNP
rs74565630 764 dbSNP
rs148442664 765 dbSNP
rs1235629022 773 dbSNP
rs943959457 777 dbSNP
rs1274618375 783 dbSNP
rs1251940548 788 dbSNP
rs1182109619 791 dbSNP
rs1294442802 792 dbSNP
rs533866681 794 dbSNP
rs1206090642 805 dbSNP
rs913076225 813 dbSNP
rs1241363836 815 dbSNP
rs1251462212 817 dbSNP
rs1287730089 833 dbSNP
rs947099562 834 dbSNP
rs1347265038 835 dbSNP
rs553948336 840 dbSNP
rs1404518112 843 dbSNP
rs1388214083 845 dbSNP
rs1159924242 856 dbSNP
rs1042813464 857 dbSNP
rs879180465 863 dbSNP
rs1420606870 864 dbSNP
rs1471909808 866 dbSNP
rs1254689284 871 dbSNP
rs905491109 873 dbSNP
rs1454580094 879 dbSNP
rs1200657408 894 dbSNP
rs1451392277 903 dbSNP
rs1187826556 910 dbSNP
rs1207121947 914 dbSNP
rs746056111 922 dbSNP
rs1417361139 933 dbSNP
rs559545089 935 dbSNP
rs1172626079 955 dbSNP
rs1435568634 960 dbSNP
rs1355273471 971 dbSNP
rs1329147224 972 dbSNP
rs1056750445 975 dbSNP
rs1461153016 983 dbSNP
rs2260797 984 dbSNP
rs1432172085 985 dbSNP
rs1177772721 986 dbSNP
rs1397119728 990 dbSNP
rs896061389 1009 dbSNP
rs1250786 1010 dbSNP
rs1270124598 1014 dbSNP
rs1195713275 1015 dbSNP
rs879060983 1017 dbSNP
rs1215757971 1025 dbSNP
rs539671978 1027 dbSNP
rs1206979317 1030 dbSNP
rs1462699254 1032 dbSNP
rs1295703390 1034 dbSNP
rs1263769552 1036 dbSNP
rs1320696982 1049 dbSNP
rs1342737750 1053 dbSNP
rs556394390 1057 dbSNP
rs1227861430 1063 dbSNP
rs1274716919 1065 dbSNP
rs1364064202 1072 dbSNP
rs1318121586 1076 dbSNP
rs1454175464 1078 dbSNP
rs1468739565 1083 dbSNP
rs576273223 1085 dbSNP
rs182386178 1090 dbSNP
rs1332882582 1098 dbSNP
rs1414419042 1099 dbSNP
rs1240214155 1102 dbSNP
rs1015484278 1105 dbSNP
rs899334864 1106 dbSNP
rs868273256 1107 dbSNP
rs554663335 1109 dbSNP
rs879036610 1116 dbSNP
rs1420280646 1118 dbSNP
rs1029071490 1121 dbSNP
rs1163042359 1127 dbSNP
rs1440680732 1128 dbSNP
rs1397048693 1129 dbSNP
rs1352133905 1140 dbSNP
rs1196231431 1141 dbSNP
rs140722563 1147 dbSNP
rs540314634 1154 dbSNP
rs1247751796 1157 dbSNP
rs150049823 1160 dbSNP
rs1283140518 1162 dbSNP
rs1445128478 1163 dbSNP
rs1343900697 1173 dbSNP
rs1331441773 1176 dbSNP
rs1018984406 1179 dbSNP
rs1370341086 1179 dbSNP
rs1167057704 1182 dbSNP
rs965259453 1186 dbSNP
rs560243028 1187 dbSNP
rs868173650 1193 dbSNP
rs1471850577 1206 dbSNP
rs1354244386 1209 dbSNP
rs532541323 1215 dbSNP
rs1482651968 1220 dbSNP
rs1294736086 1234 dbSNP
rs1335075946 1236 dbSNP
rs1288692161 1244 dbSNP
rs1226175133 1248 dbSNP
rs1374893041 1249 dbSNP
rs546006377 1255 dbSNP
rs1411005445 1261 dbSNP
rs988761183 1266 dbSNP
rs1281911631 1267 dbSNP
rs1407117618 1268 dbSNP
rs1350755427 1269 dbSNP
rs1164333162 1274 dbSNP
rs913015522 1276 dbSNP
rs1410265710 1278 dbSNP
rs1159936085 1292 dbSNP
rs1216387139 1293 dbSNP
rs563159234 1297 dbSNP
rs1249487478 1310 dbSNP
rs1236896690 1311 dbSNP
rs947247979 1313 dbSNP
rs979035427 1320 dbSNP
rs927029325 1321 dbSNP
rs1318307054 1323 dbSNP
rs1284372655 1328 dbSNP
rs1227221086 1332 dbSNP
rs1420220133 1337 dbSNP
rs1475672027 1346 dbSNP
rs1286999424 1348 dbSNP
rs866357560 1349 dbSNP
rs1368770195 1354 dbSNP
rs937122457 1357 dbSNP
rs1406198689 1371 dbSNP
rs1056698781 1376 dbSNP
rs1456769622 1383 dbSNP
rs895506108 1392 dbSNP
rs531913441 1393 dbSNP
rs1160451823 1398 dbSNP
rs1189193561 1401 dbSNP
rs1486671053 1415 dbSNP
rs548908018 1420 dbSNP
rs940907176 1425 dbSNP
rs1036624463 1426 dbSNP
rs1264400572 1433 dbSNP
rs1313261387 1438 dbSNP
rs899446832 1446 dbSNP
rs374642485 1452 dbSNP
rs995014462 1454 dbSNP
rs1441063616 1455 dbSNP
rs1029598274 1456 dbSNP
rs567953207 1460 dbSNP
rs1434570341 1463 dbSNP
rs1386548338 1464 dbSNP
rs1250787 1465 dbSNP
rs1279437481 1467 dbSNP
rs1345663158 1477 dbSNP
rs199491910 1478 dbSNP
rs1430080919 1479 dbSNP
rs889191674 1486 dbSNP
rs1187556469 1487 dbSNP
rs547492187 1492 dbSNP
rs570581752 1495 dbSNP
rs539610115 1497 dbSNP
rs1255913900 1499 dbSNP
rs549718884 1512 dbSNP
rs1008997512 1513 dbSNP
rs1227979553 1516 dbSNP
rs1181332389 1517 dbSNP
rs1231448489 1523 dbSNP
rs368649080 1524 dbSNP
rs745370158 1533 dbSNP
rs1394944658 1539 dbSNP
rs1433425399 1542 dbSNP
rs1167689398 1543 dbSNP
rs1427450833 1546 dbSNP
rs1386688424 1547 dbSNP
rs1187714944 1548 dbSNP
rs1422713305 1549 dbSNP
rs956691638 1551 dbSNP
rs1174927113 1553 dbSNP
rs569879856 1554 dbSNP
rs1375500631 1555 dbSNP
rs989099073 1556 dbSNP
rs186448262 1558 dbSNP
rs1267452890 1571 dbSNP
rs1245690117 1576 dbSNP
rs1321212334 1584 dbSNP
rs1310582690 1586 dbSNP
rs1408924135 1587 dbSNP
rs771424994 1588 dbSNP
rs969064797 1590 dbSNP
rs1337169204 1594 dbSNP
rs1442598400 1595 dbSNP
rs377093922 1596 dbSNP
rs1165471223 1603 dbSNP
rs1367110376 1606 dbSNP
rs978605923 1609 dbSNP
rs369754961 1610 dbSNP
rs1366234188 1613 dbSNP
rs1160591630 1618 dbSNP
rs147041124 1619 dbSNP
rs937070357 1632 dbSNP
rs574472077 1640 dbSNP
rs916880674 1653 dbSNP
rs767118033 1658 dbSNP
rs940362834 1668 dbSNP
rs1036478392 1676 dbSNP
rs920836326 1681 dbSNP
rs930919448 1682 dbSNP
rs1287630954 1692 dbSNP
rs1050555000 1696 dbSNP
rs1332610626 1702 dbSNP
rs866838038 1706 dbSNP
rs533955623 1708 dbSNP
rs889306190 1709 dbSNP
rs1008944925 1719 dbSNP
rs1040487240 1721 dbSNP
rs1159093594 1725 dbSNP
rs892586655 1726 dbSNP
rs879774134 1731 dbSNP
rs1379766154 1739 dbSNP
rs1451303617 1743 dbSNP
rs553816714 1749 dbSNP
rs1196039407 1752 dbSNP
rs1009566236 1753 dbSNP
rs1210728968 1766 dbSNP
rs199491911 1771 dbSNP
rs1267507696 1779 dbSNP
rs1206775487 1781 dbSNP
rs576937658 1786 dbSNP
rs1275272278 1791 dbSNP
rs968637561 1793 dbSNP
rs1000541403 1800 dbSNP
rs1398130088 1818 dbSNP
rs1435293592 1819 dbSNP
rs1387285748 1823 dbSNP
rs1317912258 1832 dbSNP
rs1399492017 1834 dbSNP
rs1404959283 1835 dbSNP
rs546334455 1838 dbSNP
rs1324853840 1851 dbSNP
rs1477905604 1851 dbSNP
rs1190755134 1859 dbSNP
rs562934146 1867 dbSNP
rs576614866 1868 dbSNP
rs1304057702 1885 dbSNP
rs958540241 1894 dbSNP
rs542141394 1895 dbSNP
rs562393790 1898 dbSNP
rs1342618045 1906 dbSNP
rs1341684781 1909 dbSNP
rs1228709167 1910 dbSNP
rs1294816434 1915 dbSNP
rs1363956063 1915 dbSNP
rs1199471710 1920 dbSNP
rs962126394 1932 dbSNP
rs527250104 1936 dbSNP
rs1335461783 1941 dbSNP
rs920266200 1943 dbSNP
rs1374054098 1945 dbSNP
rs138255992 1957 dbSNP
rs1430690991 1958 dbSNP
rs1215947385 1959 dbSNP
rs561216425 1963 dbSNP
rs2700013 1965 dbSNP
rs1238057899 1969 dbSNP
rs1186766821 1978 dbSNP
rs1446957787 1982 dbSNP
rs397834164 1983 dbSNP
rs1205567610 1985 dbSNP
rs1341077861 1995 dbSNP
rs1272020286 2000 dbSNP
rs1229597914 2010 dbSNP
rs1356457937 2024 dbSNP
rs1447987826 2027 dbSNP
rs1354081808 2031 dbSNP
rs1310293908 2033 dbSNP
rs1410814761 2034 dbSNP
rs1190352136 2040 dbSNP
rs944847524 2042 dbSNP
rs1040603821 2047 dbSNP
rs1371428450 2048 dbSNP
rs1162697206 2051 dbSNP
rs892540264 2055 dbSNP
rs1253854325 2060 dbSNP
rs1163740903 2074 dbSNP
rs191211600 2076 dbSNP
rs1249281249 2089 dbSNP
rs761080986 2095 dbSNP
rs1043711855 2098 dbSNP
rs1288579110 2108 dbSNP
rs1462755522 2113 dbSNP
rs1326344499 2126 dbSNP
rs1384097303 2127 dbSNP
rs533062859 2134 dbSNP
rs549889412 2135 dbSNP
rs903857342 2136 dbSNP
rs569737682 2138 dbSNP
rs1328251182 2143 dbSNP
rs1229481200 2146 dbSNP
rs1219402692 2148 dbSNP
rs535669443 2156 dbSNP
rs868823337 2169 dbSNP
rs2757101 2170 dbSNP
rs2260749 2174 dbSNP
rs77779791 2177 dbSNP
rs1266440975 2180 dbSNP
rs368969017 2181 dbSNP
rs145993070 2183 dbSNP
rs546859493 2184 dbSNP
rs1472198405 2185 dbSNP
rs1405564771 2189 dbSNP
rs1264554390 2192 dbSNP
rs139877537 2200 dbSNP
rs961791079 2204 dbSNP
rs183334565 2209 dbSNP
rs1254881100 2210 dbSNP
rs1475995824 2211 dbSNP
rs761549925 2220 dbSNP
rs1743568 2232 dbSNP
rs556650257 2249 dbSNP
rs1305360492 2253 dbSNP
rs1221271659 2255 dbSNP
rs1451417425 2258 dbSNP
rs951808018 2259 dbSNP
rs1385588627 2261 dbSNP
rs1274477997 2263 dbSNP
rs1400629103 2265 dbSNP
rs143226021 2285 dbSNP
rs1321260321 2287 dbSNP
rs910802907 2290 dbSNP
rs944962856 2297 dbSNP
rs1353758206 2304 dbSNP
rs1414822205 2304 dbSNP
rs1424125237 2307 dbSNP
rs542429197 2309 dbSNP
rs914075968 2313 dbSNP
rs562333366 2324 dbSNP
rs945443641 2327 dbSNP
rs1316685555 2329 dbSNP
rs1187350489 2340 dbSNP
rs146183355 2348 dbSNP
rs1212760708 2349 dbSNP
rs1279981296 2353 dbSNP
rs1262942341 2356 dbSNP
rs369094692 2358 dbSNP
rs1298488481 2363 dbSNP
rs1209462567 2365 dbSNP
rs1359865235 2366 dbSNP
rs1277612753 2378 dbSNP
rs903970773 2381 dbSNP
rs938010986 2387 dbSNP
rs1055073468 2399 dbSNP
rs1167476343 2403 dbSNP
rs142505180 2406 dbSNP
rs1014137005 2411 dbSNP
rs1249451594 2437 dbSNP
rs1024117979 2443 dbSNP
rs897655296 2444 dbSNP
rs1209153790 2446 dbSNP
rs564062235 2453 dbSNP
rs531895881 2461 dbSNP
rs187635832 2463 dbSNP
rs1027807921 2474 dbSNP
rs951867268 2484 dbSNP
rs985773231 2491 dbSNP
rs1171735450 2493 dbSNP
rs1396567890 2496 dbSNP
rs1373689932 2499 dbSNP
rs1378308160 2502 dbSNP
rs1017296605 2518 dbSNP
rs1320400149 2525 dbSNP
rs1310895050 2533 dbSNP
rs966261905 2548 dbSNP
rs1307029120 2553 dbSNP
rs1370854890 2553 dbSNP
rs1460097313 2566 dbSNP
rs1303643429 2568 dbSNP
rs1372874658 2572 dbSNP
rs1369717507 2580 dbSNP
rs1164831169 2584 dbSNP
rs1389967638 2590 dbSNP
rs1309628162 2594 dbSNP
rs1378247160 2608 dbSNP
rs1234162651 2610 dbSNP
rs549590300 2612 dbSNP
rs1252920063 2617 dbSNP
rs1195467086 2626 dbSNP
rs1479757450 2646 dbSNP
rs976336254 2648 dbSNP
rs1334138020 2649 dbSNP
rs1291356260 2653 dbSNP
rs1349401714 2658 dbSNP
rs1350895302 2660 dbSNP
rs1327879843 2665 dbSNP
rs867028376 2669 dbSNP
rs914042484 2672 dbSNP
rs1250358984 2679 dbSNP
rs1392410369 2683 dbSNP
rs796849695 2685 dbSNP
rs1479467288 2688 dbSNP
rs945529081 2691 dbSNP
rs563420721 2692 dbSNP
rs1473830004 2696 dbSNP
rs1413200912 2699 dbSNP
rs1181496489 2720 dbSNP
rs1417609099 2724 dbSNP
rs1269719016 2725 dbSNP
rs1210579507 2732 dbSNP
rs1468092935 2733 dbSNP
rs979664023 2749 dbSNP
rs529047328 2753 dbSNP
rs199576055 2756 dbSNP
rs116942435 2757 dbSNP
rs1439634495 2757 dbSNP
rs534012209 2757 dbSNP
rs66479227 2758 dbSNP
rs1191658195 2766 dbSNP
rs1396888670 2767 dbSNP
rs1434910999 2768 dbSNP
rs1176898149 2773 dbSNP
rs1321924506 2777 dbSNP
rs1354103381 2778 dbSNP
rs192862574 2782 dbSNP
rs1333662287 2784 dbSNP
rs1046068295 2787 dbSNP
rs1199864473 2787 dbSNP
rs1452073694 2787 dbSNP
rs1440700836 2788 dbSNP
rs565594681 2795 dbSNP
rs528369417 2796 dbSNP
rs551301254 2797 dbSNP
rs1203246249 2798 dbSNP
rs1256322162 2799 dbSNP
rs1346879056 2799 dbSNP
rs1250789 2800 dbSNP
rs1007335658 2801 dbSNP
rs1017244275 2805 dbSNP
rs1435171121 2809 dbSNP
rs1327596083 2813 dbSNP
rs1318252179 2815 dbSNP
rs1305298375 2818 dbSNP
rs1404824417 2821 dbSNP
rs965711753 2823 dbSNP
rs997228629 2825 dbSNP
rs1170639637 2828 dbSNP
rs1181904855 2844 dbSNP
rs1467867014 2853 dbSNP
rs1190965962 2856 dbSNP
rs1256646490 2857 dbSNP
rs539847495 2863 dbSNP
rs1345367237 2864 dbSNP
rs1228598363 2866 dbSNP
rs1338192433 2867 dbSNP
rs1250790 2869 dbSNP
rs1488777970 2870 dbSNP
rs1191799539 2874 dbSNP
rs751722808 2878 dbSNP
rs967010949 2882 dbSNP
rs1418854038 2883 dbSNP
rs371282767 2884 dbSNP
rs979997135 2893 dbSNP
rs1166202280 2894 dbSNP
rs925488900 2903 dbSNP
rs1418466981 2904 dbSNP
rs878911202 2911 dbSNP
rs570149999 2915 dbSNP
rs1484570008 2921 dbSNP
rs183356982 2934 dbSNP
rs1205452378 2936 dbSNP
rs990865945 2942 dbSNP
rs1270320755 2944 dbSNP
rs1229512639 2956 dbSNP
rs1352084608 2959 dbSNP
rs556000077 2969 dbSNP
rs1250791 2971 dbSNP
rs1288849777 2976 dbSNP
rs949379419 2979 dbSNP
rs149149555 2983 dbSNP
rs919148556 2984 dbSNP
rs1290554630 2988 dbSNP
rs1443256986 2991 dbSNP
rs1354138662 2995 dbSNP
rs143230318 2999 dbSNP
rs1049346188 3000 dbSNP
rs1395222657 3005 dbSNP
rs887613949 3006 dbSNP
rs1007283375 3007 dbSNP
rs1413940580 3011 dbSNP
rs1177535016 3015 dbSNP
rs1172275119 3019 dbSNP
rs1469350963 3024 dbSNP
rs577539589 3039 dbSNP
rs543423006 3045 dbSNP
rs370066815 3046 dbSNP
rs563198351 3059 dbSNP
rs2945443 3063 dbSNP
rs1322143276 3068 dbSNP
rs200690937 3073 dbSNP
rs1333297318 3080 dbSNP
rs997573912 3091 dbSNP
rs1020647816 3096 dbSNP
rs1372956406 3102 dbSNP
rs141772176 3107 dbSNP
rs1438804376 3128 dbSNP
rs1371845548 3144 dbSNP
rs1325253921 3146 dbSNP
rs1459843820 3153 dbSNP
rs1001141439 3154 dbSNP
rs1195938819 3156 dbSNP
rs138631936 3162 dbSNP
rs528302009 3164 dbSNP
rs959539173 3166 dbSNP
rs1475022539 3182 dbSNP
rs1454419303 3190 dbSNP
rs551238109 3193 dbSNP
rs1251881271 3197 dbSNP
rs1167000016 3203 dbSNP
rs990982037 3212 dbSNP
rs1467572162 3216 dbSNP
rs1244332867 3220 dbSNP
rs2559785 3221 dbSNP
rs1406379492 3223 dbSNP
rs1159017234 3229 dbSNP
rs1282534349 3233 dbSNP
rs187847988 3241 dbSNP
rs533139087 3242 dbSNP
rs1438782671 3249 dbSNP
rs1367366937 3260 dbSNP
rs918607443 3270 dbSNP
rs1298297555 3271 dbSNP
rs1343251884 3281 dbSNP
rs929176838 3283 dbSNP
rs1435001801 3297 dbSNP
rs1354384223 3299 dbSNP
rs1048981669 3301 dbSNP
rs1171275844 3304 dbSNP
rs3827877 3307 dbSNP
rs149464575 3308 dbSNP
rs1379607223 3312 dbSNP
rs1223067072 3316 dbSNP
rs570005224 3317 dbSNP
rs745443508 3323 dbSNP
rs71186300 3325 dbSNP
rs1038909326 3327 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions TZM-bl
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM1462574. RNA binding protein: AGO2. Condition:TZM-bl ami BaL ...

- Whisnant AW; Bogerd HP; Flores O; Ho P; et al., 2013, mBio.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' acgaacgacGGAGAGGGGAGGGu 5'
                   |:| | ||||||| 
Target 5' --------cCUUGUGCCCUCCCc 3'
 		1 - 15
2 
miRNA  3' acGAACGACGGA-GAGGGGAgggu 5'
            ||||  |:||  ||||||    
Target 5' ucCUUG--GUCUGGUCCCCUg--- 3'
 		21 - 39
Article - Whisnant AW; Bogerd HP; Flores O; Ho P; et al.
- mBio, 2013
UNLABELLED: The question of how HIV-1 interfaces with cellular microRNA (miRNA) biogenesis and effector mechanisms has been highly controversial. Here, we first used deep sequencing of small RNAs present in two different infected cell lines (TZM-bl and C8166) and two types of primary human cells (CD4(+) peripheral blood mononuclear cells [PBMCs] and macrophages) to unequivocally demonstrate that HIV-1 does not encode any viral miRNAs. Perhaps surprisingly, we also observed that infection of T cells by HIV-1 has only a modest effect on the expression of cellular miRNAs at early times after infection. Comprehensive analysis of miRNA binding to the HIV-1 genome using the photoactivatable ribonucleoside-induced cross-linking and immunoprecipitation (PAR-CLIP) technique revealed several binding sites for cellular miRNAs, a subset of which were shown to be capable of mediating miRNA-mediated repression of gene expression. However, the main finding from this analysis is that HIV-1 transcripts are largely refractory to miRNA binding, most probably due to extensive viral RNA secondary structure. Together, these data demonstrate that HIV-1 neither encodes viral miRNAs nor strongly influences cellular miRNA expression, at least early after infection, and imply that HIV-1 transcripts have evolved to avoid inhibition by preexisting cellular miRNAs by adopting extensive RNA secondary structures that occlude most potential miRNA binding sites. IMPORTANCE: MicroRNAs (miRNAs) are a ubiquitous class of small regulatory RNAs that serve as posttranscriptional regulators of gene expression. Previous work has suggested that HIV-1 might subvert the function of the cellular miRNA machinery by expressing viral miRNAs or by dramatically altering the level of cellular miRNA expression. Using very sensitive approaches, we now demonstrate that neither of these ideas is in fact correct. Moreover, HIV-1 transcripts appear to largely avoid regulation by cellular miRNAs by adopting an extensive RNA secondary structure that occludes the ability of cellular miRNAs to interact with viral mRNAs. Together, these data suggest that HIV-1, rather than seeking to control miRNA function in infected cells, has instead evolved a mechanism to become largely invisible to cellular miRNA effector mechanisms.
LinkOut: [PMID: 23592263]
Experimental Support 2 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HCT116
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in ERX177616. RNA binding protein: AGO2. Condition:p53_V_AGO_CLIP_3_6 PAR-CLIP data was present in ERX177618. RNA binding protein: AGO2. Condition:KO_V_AGO_CLIP_3_8 PAR-CLIP data was present in ERX177630. RNA binding protein: AGO2. Condition:KO_V_AGO_CLIP_4_8 PAR-CLIP data was present in ERX177606. RNA binding protein: AGO2. Condition:KO_V_AGO_CLIP_2_8 PAR-CLIP data was present in ERX177629. RNA binding protein: AGO2. Condition:KO_D_AGO_CLIP_4_7 ...

- Krell J; Stebbing J; Carissimi C; Dabrowska et al., 2016, Genome research.

Article - Krell J; Stebbing J; Carissimi C; Dabrowska et al.
- Genome research, 2016
DNA damage activates TP53-regulated surveillance mechanisms that are crucial in suppressing tumorigenesis. TP53 orchestrates these responses directly by transcriptionally modulating genes, including microRNAs (miRNAs), and by regulating miRNA biogenesis through interacting with the DROSHA complex. However, whether the association between miRNAs and AGO2 is regulated following DNA damage is not yet known. Here, we show that, following DNA damage, TP53 interacts with AGO2 to induce or reduce AGO2's association of a subset of miRNAs, including multiple let-7 family members. Furthermore, we show that specific mutations in TP53 decrease rather than increase the association of let-7 family miRNAs, reducing their activity without preventing TP53 from interacting with AGO2. This is consistent with the oncogenic properties of these mutants. Using AGO2 RIP-seq and PAR-CLIP-seq, we show that the DNA damage-induced increase in binding of let-7 family members to the RISC complex is functional. We unambiguously determine the global miRNA-mRNA interaction networks involved in the DNA damage response, validating them through the identification of miRNA-target chimeras formed by endogenous ligation reactions. We find that the target complementary region of the let-7 seed tends to have highly fixed positions and more variable ones. Additionally, we observe that miRNAs, whose cellular abundance or differential association with AGO2 is regulated by TP53, are involved in an intricate network of regulatory feedback and feedforward circuits. TP53-mediated regulation of AGO2-miRNA interaction represents a new mechanism of miRNA regulation in carcinogenesis.
LinkOut: [PMID: 26701625]
CLIP-seq Support 1 for dataset GSM1462574
Method / RBP PAR-CLIP / AGO2
Cell line / Condition TZM-bl / TZM-bl ami BaL
Location of target site ENST00000520547.2 | 3UTR | CCUUGUGCCCUCCCCACUCAUCCUUGGUCUGGUCCCCUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23592263 / GSE59944
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
612 hsa-miR-4728-5p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT083283 ZCCHC3 zinc finger CCHC-type containing 3 2 4
MIRT112203 BTG2 BTG anti-proliferation factor 2 2 2
MIRT115286 JUN Jun proto-oncogene, AP-1 transcription factor subunit 2 2
MIRT115527 MAZ MYC associated zinc finger protein 2 2
MIRT119866 NRBP1 nuclear receptor binding protein 1 2 2
MIRT131979 IER5 immediate early response 5 2 4
MIRT149428 CARM1 coactivator associated arginine methyltransferase 1 2 2
MIRT160081 TET3 tet methylcytosine dioxygenase 3 2 2
MIRT177169 ARL5B ADP ribosylation factor like GTPase 5B 2 4
MIRT260103 KLHL21 kelch like family member 21 2 2
MIRT260351 XRCC6 X-ray repair cross complementing 6 2 6
MIRT266417 RPRD2 regulation of nuclear pre-mRNA domain containing 2 2 2
MIRT294650 ZNF548 zinc finger protein 548 2 2
MIRT339335 SESN2 sestrin 2 2 2
MIRT386434 CCL22 C-C motif chemokine ligand 22 2 4
MIRT441468 BEST3 bestrophin 3 2 2
MIRT442283 CCDC108 cilia and flagella associated protein 65 2 4
MIRT446756 ZNF491 zinc finger protein 491 2 2
MIRT449229 RAD51B RAD51 paralog B 2 2
MIRT451011 MYH14 myosin heavy chain 14 2 8
MIRT451099 ZNF584 zinc finger protein 584 2 2
MIRT451412 TJP3 tight junction protein 3 2 4
MIRT451566 CIAPIN1 cytokine induced apoptosis inhibitor 1 2 2
MIRT451742 CES3 carboxylesterase 3 2 2
MIRT451949 TMPRSS5 transmembrane protease, serine 5 2 2
MIRT452324 EIF5AL1 eukaryotic translation initiation factor 5A-like 1 2 2
MIRT452417 QDPR quinoid dihydropteridine reductase 2 2
MIRT452569 ZFP69B ZFP69 zinc finger protein B 2 2
MIRT452863 LAX1 lymphocyte transmembrane adaptor 1 2 2
MIRT452928 DISC1 disrupted in schizophrenia 1 2 2
MIRT453054 TANGO2 transport and golgi organization 2 homolog 2 4
MIRT453104 HOXC4 homeobox C4 2 2
MIRT453243 FTSJ3 FtsJ RNA methyltransferase homolog 3 2 2
MIRT453302 ZNF394 zinc finger protein 394 2 2
MIRT453335 PLEKHG2 pleckstrin homology and RhoGEF domain containing G2 2 2
MIRT453545 PRR12 proline rich 12 2 2
MIRT453600 ZNF557 zinc finger protein 557 2 2
MIRT453801 KBTBD12 kelch repeat and BTB domain containing 12 2 2
MIRT453993 CECR1 adenosine deaminase 2 2 2
MIRT454090 TMEM209 transmembrane protein 209 2 2
MIRT454212 HLA-A major histocompatibility complex, class I, A 2 2
MIRT454293 ZNF134 zinc finger protein 134 2 2
MIRT454456 PPP2R2B protein phosphatase 2 regulatory subunit Bbeta 2 2
MIRT454475 SLC29A1 solute carrier family 29 member 1 (Augustine blood group) 2 2
MIRT454661 FBXL18 F-box and leucine rich repeat protein 18 2 2
MIRT454789 STOML3 stomatin like 3 2 2
MIRT455125 TBC1D25 TBC1 domain family member 25 2 2
MIRT455314 TTLL9 tubulin tyrosine ligase like 9 2 2
MIRT456123 SAMD10 sterile alpha motif domain containing 10 2 2
MIRT456152 TTF2 transcription termination factor 2 2 2
MIRT456304 ARHGEF2 Rho/Rac guanine nucleotide exchange factor 2 2 2
MIRT456475 SERAC1 serine active site containing 1 2 2
MIRT456558 TOMM20 translocase of outer mitochondrial membrane 20 2 2
MIRT456724 TMEM239 transmembrane protein 239 2 4
MIRT457390 CAMK2A calcium/calmodulin dependent protein kinase II alpha 2 2
MIRT457427 NOL10 nucleolar protein 10 2 2
MIRT457492 SLC35F6 solute carrier family 35 member F6 2 2
MIRT458004 MRPL12 mitochondrial ribosomal protein L12 2 2
MIRT458136 TLCD2 TLC domain containing 2 2 2
MIRT458596 KCTD2 potassium channel tetramerization domain containing 2 2 2
MIRT459031 ZNF490 zinc finger protein 490 2 4
MIRT459124 FADS6 fatty acid desaturase 6 2 2
MIRT459322 HAVCR2 hepatitis A virus cellular receptor 2 2 2
MIRT459393 MPLKIP M-phase specific PLK1 interacting protein 2 2
MIRT459421 FAM83B family with sequence similarity 83 member B 2 2
MIRT459498 TACR3 tachykinin receptor 3 2 2
MIRT459566 NLGN2 neuroligin 2 2 2
MIRT459605 KCNK3 potassium two pore domain channel subfamily K member 3 2 2
MIRT459667 VPS37C VPS37C, ESCRT-I subunit 2 2
MIRT459917 HHIP hedgehog interacting protein 2 4
MIRT459983 RFT1 RFT1 homolog 2 2
MIRT460487 FAM105A family with sequence similarity 105 member A 2 6
MIRT460611 FEM1A fem-1 homolog A 2 2
MIRT460650 IGFBP4 insulin like growth factor binding protein 4 2 2
MIRT460679 RNF157 ring finger protein 157 2 2
MIRT460711 FN3KRP fructosamine 3 kinase related protein 2 2
MIRT460880 UBE2S ubiquitin conjugating enzyme E2 S 2 2
MIRT460927 NOA1 nitric oxide associated 1 2 4
MIRT461080 OPA3 OPA3, outer mitochondrial membrane lipid metabolism regulator 2 2
MIRT461597 DPH2 DPH2 homolog 2 2
MIRT461861 ZNF317 zinc finger protein 317 2 2
MIRT462185 ACADL acyl-CoA dehydrogenase, long chain 2 2
MIRT462452 GCDH glutaryl-CoA dehydrogenase 2 2
MIRT462994 ZNF740 zinc finger protein 740 2 2
MIRT463327 ZFHX3 zinc finger homeobox 3 2 2
MIRT463859 WNT7B Wnt family member 7B 2 2
MIRT464061 WAC WW domain containing adaptor with coiled-coil 2 2
MIRT464318 UST uronyl 2-sulfotransferase 2 2
MIRT464823 UBE2B ubiquitin conjugating enzyme E2 B 2 2
MIRT465409 TP53 tumor protein p53 2 2
MIRT466082 TMEM184C transmembrane protein 184C 2 2
MIRT466525 TBXA2R thromboxane A2 receptor 2 2
MIRT467079 SRRD SRR1 domain containing 2 2
MIRT467153 SREBF2 sterol regulatory element binding transcription factor 2 2 2
MIRT468101 SH3TC2 SH3 domain and tetratricopeptide repeats 2 2 2
MIRT468289 SFT2D2 SFT2 domain containing 2 2 4
MIRT468763 SCD stearoyl-CoA desaturase 2 2
MIRT468915 RPS6KA4 ribosomal protein S6 kinase A4 2 2
MIRT469161 RNF111 ring finger protein 111 2 2
MIRT469211 RICTOR RPTOR independent companion of MTOR complex 2 2 2
MIRT469748 RAB2B RAB2B, member RAS oncogene family 2 2
MIRT470597 POTEM POTE ankyrin domain family member M 2 2
MIRT470627 POTEG POTE ankyrin domain family member G 2 2
MIRT470772 PNPLA6 patatin like phospholipase domain containing 6 2 2
MIRT470883 PLXND1 plexin D1 2 2
MIRT470984 PITPNA phosphatidylinositol transfer protein alpha 2 2
MIRT471224 PHAX phosphorylated adaptor for RNA export 2 2
MIRT471254 PGM2L1 phosphoglucomutase 2 like 1 2 2
MIRT471304 PGAM4 phosphoglycerate mutase family member 4 2 2
MIRT471473 PDE7B phosphodiesterase 7B 2 2
MIRT471772 NUP43 nucleoporin 43 2 4
MIRT472062 NOVA2 NOVA alternative splicing regulator 2 2 2
MIRT472177 NHP2L1 small nuclear ribonucleoprotein 13 2 2
MIRT472220 NGFR nerve growth factor receptor 2 2
MIRT472293 NFAT5 nuclear factor of activated T-cells 5 2 2
MIRT473073 MORN4 MORN repeat containing 4 2 2
MIRT473094 MLXIP MLX interacting protein 2 2
MIRT473202 MINK1 misshapen like kinase 1 2 2
MIRT473496 MBD6 methyl-CpG binding domain protein 6 2 2
MIRT473546 MAVS mitochondrial antiviral signaling protein 2 2
MIRT473573 MAT2A methionine adenosyltransferase 2A 2 6
MIRT473632 MARK2 microtubule affinity regulating kinase 2 2 2
MIRT473999 LRRC20 leucine rich repeat containing 20 2 2
MIRT474841 KHSRP KH-type splicing regulatory protein 2 4
MIRT474998 KANSL1 KAT8 regulatory NSL complex subunit 1 2 2
MIRT475135 IP6K1 inositol hexakisphosphate kinase 1 2 2
MIRT475581 HMGXB4 HMG-box containing 4 2 2
MIRT477305 EPHB2 EPH receptor B2 2 2
MIRT477377 ENTPD7 ectonucleoside triphosphate diphosphohydrolase 7 2 2
MIRT477950 DPM2 dolichyl-phosphate mannosyltransferase subunit 2, regulatory 2 2
MIRT478291 DDX19A DEAD-box helicase 19A 2 4
MIRT478477 CYP20A1 cytochrome P450 family 20 subfamily A member 1 2 2
MIRT478593 CTDSP2 CTD small phosphatase 2 2 3
MIRT478629 CTDNEP1 CTD nuclear envelope phosphatase 1 2 2
MIRT478842 CRISPLD2 cysteine rich secretory protein LCCL domain containing 2 2 2
MIRT479014 COL5A1 collagen type V alpha 1 chain 2 2
MIRT479119 CNBP CCHC-type zinc finger nucleic acid binding protein 2 4
MIRT479172 CLSPN claspin 2 2
MIRT480147 CALR calreticulin 2 2
MIRT481401 ASXL1 additional sex combs like 1, transcriptional regulator 2 2
MIRT482023 AMER1 APC membrane recruitment protein 1 2 2
MIRT482147 AK2 adenylate kinase 2 2 2
MIRT482353 AGO2 argonaute 2, RISC catalytic component 2 12
MIRT482645 FAM195B MAPK regulated corepressor interacting protein 1 2 4
MIRT482812 TRAF6 TNF receptor associated factor 6 2 2
MIRT483331 CHRDL1 chordin like 1 2 8
MIRT483623 NAV2 neuron navigator 2 2 2
MIRT483657 QSOX2 quiescin sulfhydryl oxidase 2 2 4
MIRT483702 ASPH aspartate beta-hydroxylase 2 2
MIRT483808 CYP2W1 cytochrome P450 family 2 subfamily W member 1 2 6
MIRT483860 EMID1 EMI domain containing 1 2 2
MIRT483931 LENG8 leukocyte receptor cluster member 8 2 4
MIRT484198 SUMO1 small ubiquitin-like modifier 1 2 4
MIRT484280 AIP aryl hydrocarbon receptor interacting protein 2 4
MIRT484356 GATA6 GATA binding protein 6 2 10
MIRT484417 SNX19 sorting nexin 19 2 2
MIRT484430 RAB7A RAB7A, member RAS oncogene family 2 4
MIRT484575 HACE1 HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1 2 2
MIRT484844 ZNF70 zinc finger protein 70 2 6
MIRT485268 PLEKHA3 pleckstrin homology domain containing A3 2 2
MIRT485927 PGPEP1 pyroglutamyl-peptidase I 2 6
MIRT485991 YIPF2 Yip1 domain family member 2 2 2
MIRT486092 SLC7A5 solute carrier family 7 member 5 2 4
MIRT486114 INO80E INO80 complex subunit E 2 2
MIRT486310 SIPA1 signal-induced proliferation-associated 1 2 2
MIRT486376 TIGD5 tigger transposable element derived 5 2 2
MIRT486434 NDUFA5 NADH:ubiquinone oxidoreductase subunit A5 2 2
MIRT486723 MGAT5B mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase, isozyme B 2 4
MIRT486790 PARP11 poly(ADP-ribose) polymerase family member 11 2 2
MIRT486890 TSPYL4 TSPY like 4 2 4
MIRT487040 C10orf55 chromosome 10 open reading frame 55 2 2
MIRT487130 NCOR2 nuclear receptor corepressor 2 2 2
MIRT487156 LINGO3 leucine rich repeat and Ig domain containing 3 2 2
MIRT487228 CBS cystathionine-beta-synthase 2 4
MIRT487332 SREBF1 sterol regulatory element binding transcription factor 1 2 4
MIRT487414 CACNB1 calcium voltage-gated channel auxiliary subunit beta 1 2 2
MIRT487551 TM6SF2 transmembrane 6 superfamily member 2 2 4
MIRT487580 FAM83H family with sequence similarity 83 member H 2 4
MIRT487609 C20orf96 chromosome 20 open reading frame 96 2 2
MIRT487681 B3GALT5 beta-1,3-galactosyltransferase 5 2 4
MIRT487692 CDK14 cyclin dependent kinase 14 2 2
MIRT487832 CLSTN1 calsyntenin 1 2 6
MIRT487875 CASZ1 castor zinc finger 1 2 4
MIRT487899 CST9 cystatin 9 2 2
MIRT487950 IQSEC2 IQ motif and Sec7 domain 2 2 2
MIRT488094 DLGAP3 DLG associated protein 3 2 4
MIRT488188 MAT1A methionine adenosyltransferase 1A 2 2
MIRT488235 DNLZ DNL-type zinc finger 2 2
MIRT488279 PARS2 prolyl-tRNA synthetase 2, mitochondrial 2 2
MIRT488410 NKX6-2 NK6 homeobox 2 2 4
MIRT488533 GPATCH3 G-patch domain containing 3 2 2
MIRT488686 NAT9 N-acetyltransferase 9 (putative) 2 2
MIRT489040 PRPF4B pre-mRNA processing factor 4B 2 2
MIRT489052 STARD3 StAR related lipid transfer domain containing 3 2 2
MIRT489116 PPFIA3 PTPRF interacting protein alpha 3 2 3
MIRT489170 ANKRD45 ankyrin repeat domain 45 2 4
MIRT489225 ASCL2 achaete-scute family bHLH transcription factor 2 2 4
MIRT489257 TTLL1 tubulin tyrosine ligase like 1 2 4
MIRT489283 RBM8A RNA binding motif protein 8A 2 8
MIRT489358 SYNGR1 synaptogyrin 1 2 4
MIRT489375 RAB11B RAB11B, member RAS oncogene family 2 6
MIRT489473 SLITRK5 SLIT and NTRK like family member 5 2 2
MIRT489505 CRLF3 cytokine receptor like factor 3 2 4
MIRT489574 SSBP2 single stranded DNA binding protein 2 2 2
MIRT489697 SCAMP4 secretory carrier membrane protein 4 2 2
MIRT489849 ATP2A3 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3 2 2
MIRT490074 PRRT2 proline rich transmembrane protein 2 2 4
MIRT490177 TMEM63C transmembrane protein 63C 2 2
MIRT490204 PKNOX2 PBX/knotted 1 homeobox 2 2 2
MIRT490277 ZNF562 zinc finger protein 562 2 4
MIRT490286 ISL2 ISL LIM homeobox 2 2 2
MIRT490300 HOXB13 homeobox B13 2 2
MIRT490607 SLC47A1 solute carrier family 47 member 1 2 4
MIRT490679 SSTR1 somatostatin receptor 1 2 2
MIRT490751 SRCIN1 SRC kinase signaling inhibitor 1 2 2
MIRT490914 STRN4 striatin 4 2 2
MIRT491042 CHST12 carbohydrate sulfotransferase 12 2 2
MIRT491092 MSI1 musashi RNA binding protein 1 2 4
MIRT491125 PTPRE protein tyrosine phosphatase, receptor type E 2 2
MIRT491206 MLLT1 MLLT1, super elongation complex subunit 2 6
MIRT491227 KCNA5 potassium voltage-gated channel subfamily A member 5 2 2
MIRT491265 DHX40 DEAH-box helicase 40 2 2
MIRT491392 HAUS3 HAUS augmin like complex subunit 3 2 2
MIRT491403 C1D C1D nuclear receptor corepressor 2 2
MIRT491511 CREBL2 cAMP responsive element binding protein like 2 2 2
MIRT491553 YAE1D1 Yae1 domain containing 1 2 2
MIRT491684 MNT MAX network transcriptional repressor 2 4
MIRT491733 SEMA3F semaphorin 3F 2 2
MIRT491817 ZBTB7B zinc finger and BTB domain containing 7B 2 2
MIRT491942 VPS52 VPS52, GARP complex subunit 2 2
MIRT492156 STK11 serine/threonine kinase 11 2 4
MIRT492474 RASD1 ras related dexamethasone induced 1 2 4
MIRT492531 PSMD11 proteasome 26S subunit, non-ATPase 11 2 2
MIRT492562 PPM1L protein phosphatase, Mg2+/Mn2+ dependent 1L 2 4
MIRT492684 PHYHIP phytanoyl-CoA 2-hydroxylase interacting protein 2 2
MIRT492728 PHF12 PHD finger protein 12 2 2
MIRT492841 NRGN neurogranin 2 2
MIRT492877 NFIX nuclear factor I X 2 4
MIRT492907 NFIC nuclear factor I C 2 2
MIRT492934 NEUROD2 neuronal differentiation 2 2 2
MIRT493221 MEX3A mex-3 RNA binding family member A 2 2
MIRT493450 ITFG3 family with sequence similarity 234 member A 2 2
MIRT493672 HAP1 huntingtin associated protein 1 2 2
MIRT493875 FAM73B mitoguardin 2 2 4
MIRT494031 DUSP7 dual specificity phosphatase 7 2 4
MIRT494171 CNOT6L CCR4-NOT transcription complex subunit 6 like 2 2
MIRT494366 SOLH calpain 15 1 1
MIRT494466 BTF3L4 basic transcription factor 3 like 4 2 6
MIRT494506 BDNF-AS BDNF antisense RNA 2 2
MIRT494621 ASB6 ankyrin repeat and SOCS box containing 6 2 4
MIRT494660 ARL8A ADP ribosylation factor like GTPase 8A 2 2
MIRT494697 ARHGAP31 Rho GTPase activating protein 31 2 2
MIRT494791 ANKRD13B ankyrin repeat domain 13B 2 4
MIRT494940 IFFO2 intermediate filament family orphan 2 2 2
MIRT496591 TAGLN transgelin 2 2
MIRT497041 DYRK1B dual specificity tyrosine phosphorylation regulated kinase 1B 2 2
MIRT498592 KRT8 keratin 8 2 2
MIRT498730 SNTN sentan, cilia apical structure protein 2 6
MIRT499389 PLCG2 phospholipase C gamma 2 2 4
MIRT499798 LONRF3 LON peptidase N-terminal domain and ring finger 3 2 2
MIRT499987 HIST1H2BD histone cluster 1 H2B family member d 2 4
MIRT500446 ZFP36L1 ZFP36 ring finger protein like 1 2 2
MIRT501888 MKNK2 MAP kinase interacting serine/threonine kinase 2 2 4
MIRT503422 SLC25A45 solute carrier family 25 member 45 2 6
MIRT507784 CDKN1B cyclin dependent kinase inhibitor 1B 2 2
MIRT508894 METTL14 methyltransferase like 14 2 2
MIRT509631 RRP7A ribosomal RNA processing 7 homolog A 2 4
MIRT510111 IRAK3 interleukin 1 receptor associated kinase 3 2 8
MIRT510143 PDGFRA platelet derived growth factor receptor alpha 2 4
MIRT510628 TMEM167A transmembrane protein 167A 2 4
MIRT511025 NRF1 nuclear respiratory factor 1 2 2
MIRT512365 CPM carboxypeptidase M 2 4
MIRT512904 UBL4A ubiquitin like 4A 2 2
MIRT514349 DNAH17 dynein axonemal heavy chain 17 2 4
MIRT515021 SUMF2 sulfatase modifying factor 2 2 2
MIRT515254 DUSP28 dual specificity phosphatase 28 2 2
MIRT516212 RPP30 ribonuclease P/MRP subunit p30 2 2
MIRT516674 ZNF860 zinc finger protein 860 2 4
MIRT518382 ZNF250 zinc finger protein 250 2 2
MIRT518942 LSG1 large 60S subunit nuclear export GTPase 1 2 2
MIRT519913 ZFAND4 zinc finger AN1-type containing 4 2 2
MIRT519952 ZCCHC8 zinc finger CCHC-type containing 8 2 2
MIRT520328 UBXN2A UBX domain protein 2A 2 2
MIRT520617 TMEM41B transmembrane protein 41B 2 2
MIRT520670 TMEM11 transmembrane protein 11 2 2
MIRT520860 SUGT1 SGT1 homolog, MIS12 kinetochore complex assembly cochaperone 2 2
MIRT521450 RAD51 RAD51 recombinase 2 2
MIRT522338 NCKIPSD NCK interacting protein with SH3 domain 2 8
MIRT523488 GNG4 G protein subunit gamma 4 2 2
MIRT523680 FOPNL FGFR1OP N-terminal like 2 2
MIRT523724 FBXW2 F-box and WD repeat domain containing 2 2 4
MIRT523876 ESCO2 establishment of sister chromatid cohesion N-acetyltransferase 2 2 4
MIRT524057 DNAJC8 DnaJ heat shock protein family (Hsp40) member C8 2 2
MIRT524179 DFFA DNA fragmentation factor subunit alpha 2 2
MIRT524936 ALG10B ALG10B, alpha-1,2-glucosyltransferase 2 2
MIRT526837 PHC1 polyhomeotic homolog 1 2 2
MIRT527088 VSTM5 V-set and transmembrane domain containing 5 2 2
MIRT540687 BMP3 bone morphogenetic protein 3 2 2
MIRT541761 KLF8 Kruppel like factor 8 2 2
MIRT544292 TSPYL1 TSPY like 1 2 2
MIRT549412 ADAR adenosine deaminase, RNA specific 2 2
MIRT553369 TRIM44 tripartite motif containing 44 2 2
MIRT561757 PLAGL2 PLAG1 like zinc finger 2 2 2
MIRT562829 GCFC2 GC-rich sequence DNA-binding factor 2 2 2
MIRT562909 DNAH10OS dynein axonemal heavy chain 10 opposite strand 2 2
MIRT564459 SLC35E2 solute carrier family 35 member E2 2 4
MIRT568901 ATP6V1B1 ATPase H+ transporting V1 subunit B1 2 2
MIRT569120 ONECUT3 one cut homeobox 3 2 2
MIRT569232 SUSD1 sushi domain containing 1 2 2
MIRT569724 GPR173 G protein-coupled receptor 173 2 2
MIRT569762 SAMD14 sterile alpha motif domain containing 14 2 2
MIRT569858 KRT80 keratin 80 2 2
MIRT570283 ARPC3 actin related protein 2/3 complex subunit 3 2 2
MIRT570476 THRA thyroid hormone receptor, alpha 2 2
MIRT570854 GPRC5C G protein-coupled receptor class C group 5 member C 2 2
MIRT571198 C9orf62 chromosome 9 open reading frame 62 2 2
MIRT571322 TPCN2 two pore segment channel 2 2 2
MIRT572083 EXOC8 exocyst complex component 8 2 2
MIRT572126 DNAJC24 DnaJ heat shock protein family (Hsp40) member C24 2 2
MIRT573004 RPP25 ribonuclease P and MRP subunit p25 2 2
MIRT573491 IQSEC3 IQ motif and Sec7 domain 3 2 2
MIRT573659 HES6 hes family bHLH transcription factor 6 2 2
MIRT574351 ZBTB37 zinc finger and BTB domain containing 37 2 2
MIRT576453 Itga11 integrin alpha 11 2 3
MIRT608047 UBLCP1 ubiquitin like domain containing CTD phosphatase 1 2 2
MIRT608252 ITGA11 integrin subunit alpha 11 2 3
MIRT613668 KIAA1210 KIAA1210 2 2
MIRT615642 ATF6 activating transcription factor 6 2 2
MIRT618581 RRAD RRAD, Ras related glycolysis inhibitor and calcium channel regulator 2 2
MIRT618869 MBL2 mannose binding lectin 2 2 2
MIRT618969 MRPS16 mitochondrial ribosomal protein S16 2 2
MIRT619119 CD40LG CD40 ligand 2 2
MIRT619180 SLC16A4 solute carrier family 16 member 4 2 2
MIRT620306 AQP6 aquaporin 6 2 2
MIRT620691 RFTN2 raftlin family member 2 2 2
MIRT621646 UBXN2B UBX domain protein 2B 2 2
MIRT622004 STK4 serine/threonine kinase 4 2 2
MIRT622429 NUDT19 nudix hydrolase 19 2 2
MIRT622580 PRRG4 proline rich and Gla domain 4 2 2
MIRT622811 PGAM5 PGAM family member 5, mitochondrial serine/threonine protein phosphatase 2 4
MIRT624793 AGAP9 ArfGAP with GTPase domain, ankyrin repeat and PH domain 9 2 2
MIRT624975 ZNF665 zinc finger protein 665 2 4
MIRT625486 SMAD9 SMAD family member 9 2 2
MIRT626604 ACAA2 acetyl-CoA acyltransferase 2 2 2
MIRT626716 TRIM65 tripartite motif containing 65 2 2
MIRT626982 LINC00598 long intergenic non-protein coding RNA 598 2 2
MIRT627494 STRIP2 striatin interacting protein 2 2 2
MIRT628511 ZNF878 zinc finger protein 878 2 2
MIRT628541 ZNF701 zinc finger protein 701 2 2
MIRT628598 TMEM251 transmembrane protein 251 2 2
MIRT628825 SLC25A34 solute carrier family 25 member 34 2 2
MIRT628904 IGSF6 immunoglobulin superfamily member 6 2 2
MIRT628966 UBE2D4 ubiquitin conjugating enzyme E2 D4 (putative) 2 2
MIRT629016 OSBPL10 oxysterol binding protein like 10 2 2
MIRT629067 KIF1C kinesin family member 1C 2 2
MIRT629197 PAPOLA poly(A) polymerase alpha 2 2
MIRT629353 TMPRSS11BNL TMPRSS11B N-terminal like, pseudogene 2 2
MIRT629455 WIZ widely interspaced zinc finger motifs 2 2
MIRT629703 XKR4 XK related 4 2 2
MIRT629745 SCD5 stearoyl-CoA desaturase 5 2 2
MIRT629904 SPATA5 spermatogenesis associated 5 2 2
MIRT629961 GLP2R glucagon like peptide 2 receptor 2 2
MIRT630031 MTL5 testis expressed metallothionein like protein 2 2
MIRT630397 MYH9 myosin heavy chain 9 2 4
MIRT631140 SYNJ2 synaptojanin 2 2 2
MIRT631391 COL4A3BP collagen type IV alpha 3 binding protein 2 2
MIRT631566 TRAF3IP2 TRAF3 interacting protein 2 2 2
MIRT631623 PCDHB11 protocadherin beta 11 2 2
MIRT631942 CDKAL1 CDK5 regulatory subunit associated protein 1 like 1 2 4
MIRT632453 SGTB small glutamine rich tetratricopeptide repeat containing beta 2 2
MIRT632695 MTMR10 myotubularin related protein 10 2 2
MIRT632748 MED28 mediator complex subunit 28 2 2
MIRT632838 IGF1 insulin like growth factor 1 2 2
MIRT632917 FRRS1 ferric chelate reductase 1 2 2
MIRT633037 DNAL1 dynein axonemal light chain 1 2 2
MIRT633388 FBXW8 F-box and WD repeat domain containing 8 2 2
MIRT633448 KLLN killin, p53-regulated DNA replication inhibitor 2 2
MIRT633871 ATP6V1A ATPase H+ transporting V1 subunit A 2 2
MIRT633916 DNAH9 dynein axonemal heavy chain 9 2 2
MIRT633958 GRWD1 glutamate rich WD repeat containing 1 2 2
MIRT634050 NUP155 nucleoporin 155 2 2
MIRT634274 TIAL1 TIA1 cytotoxic granule associated RNA binding protein like 1 2 2
MIRT634381 RAP2B RAP2B, member of RAS oncogene family 2 2
MIRT634443 PDE7A phosphodiesterase 7A 2 2
MIRT634580 LRIG2 leucine rich repeats and immunoglobulin like domains 2 2 4
MIRT634704 DSEL dermatan sulfate epimerase-like 2 2
MIRT634776 CD3D CD3d molecule 2 2
MIRT635032 WWTR1 WW domain containing transcription regulator 1 2 2
MIRT636078 ZNF280C zinc finger protein 280C 2 2
MIRT636708 ARSK arylsulfatase family member K 2 2
MIRT637447 ZNF324B zinc finger protein 324B 2 2
MIRT637590 PLD6 phospholipase D family member 6 2 2
MIRT637679 PPM1D protein phosphatase, Mg2+/Mn2+ dependent 1D 2 2
MIRT637893 SLC19A3 solute carrier family 19 member 3 2 4
MIRT638362 RBMS2 RNA binding motif single stranded interacting protein 2 2 4
MIRT638604 HINT1 histidine triad nucleotide binding protein 1 2 2
MIRT638831 CRTAP cartilage associated protein 2 2
MIRT638885 CEP97 centrosomal protein 97 2 4
MIRT639663 PPEF2 protein phosphatase with EF-hand domain 2 2 4
MIRT645001 POLR2J3 RNA polymerase II subunit J3 2 2
MIRT645067 UQCRQ ubiquinol-cytochrome c reductase complex III subunit VII 2 2
MIRT646957 UPK3BL uroplakin 3B like 1 2 2
MIRT648307 SNRPD1 small nuclear ribonucleoprotein D1 polypeptide 2 4
MIRT649051 SLC1A2 solute carrier family 1 member 2 2 2
MIRT649893 SLFN12L schlafen family member 12 like 2 2
MIRT650204 DOCK7 dedicator of cytokinesis 7 2 2
MIRT652054 TTC39B tetratricopeptide repeat domain 39B 2 2
MIRT654797 PRICKLE1 prickle planar cell polarity protein 1 2 2
MIRT655930 NDUFA4P1 NDUFA4, mitochondrial complex associated pseudogene 1 2 2
MIRT655978 NAV1 neuron navigator 1 2 2
MIRT657721 GPC4 glypican 4 2 2
MIRT659309 CSTF1 cleavage stimulation factor subunit 1 2 2
MIRT659851 CAPZB capping actin protein of muscle Z-line beta subunit 2 2
MIRT661483 CHMP1B charged multivesicular body protein 1B 2 2
MIRT661914 EBNA1BP2 EBNA1 binding protein 2 2 2
MIRT661981 DSN1 DSN1 homolog, MIS12 kinetochore complex component 2 4
MIRT662074 ZNF284 zinc finger protein 284 2 2
MIRT662500 ANGPT4 angiopoietin 4 2 2
MIRT662669 LRRC47 leucine rich repeat containing 47 2 2
MIRT663174 FGFR1OP FGFR1 oncogene partner 2 2
MIRT663385 ZNF770 zinc finger protein 770 2 4
MIRT664000 WDR75 WD repeat domain 75 2 2
MIRT664167 APOBEC3F apolipoprotein B mRNA editing enzyme catalytic subunit 3F 2 2
MIRT664497 POLR3K RNA polymerase III subunit K 2 2
MIRT665065 CCDC77 coiled-coil domain containing 77 2 2
MIRT665088 CRIPT CXXC repeat containing interactor of PDZ3 domain 2 2
MIRT665725 TMTC1 transmembrane and tetratricopeptide repeat containing 1 2 2
MIRT665930 TBC1D19 TBC1 domain family member 19 2 4
MIRT666097 SSR1 signal sequence receptor subunit 1 2 2
MIRT666850 PPTC7 PTC7 protein phosphatase homolog 2 2
MIRT667390 MOB1B MOB kinase activator 1B 2 2
MIRT667583 LONRF2 LON peptidase N-terminal domain and ring finger 2 2 2
MIRT667904 ING1 inhibitor of growth family member 1 2 2
MIRT667985 HECTD3 HECT domain E3 ubiquitin protein ligase 3 2 2
MIRT668205 GCNT4 glucosaminyl (N-acetyl) transferase 4, core 2 2 2
MIRT668286 FOSL2 FOS like 2, AP-1 transcription factor subunit 2 2
MIRT668393 FAT3 FAT atypical cadherin 3 2 2
MIRT668450 FAM208A family with sequence similarity 208 member A 2 2
MIRT669005 CHORDC1 cysteine and histidine rich domain containing 1 2 2
MIRT669459 ATL3 atlastin GTPase 3 2 2
MIRT669667 ACAP2 ArfGAP with coiled-coil, ankyrin repeat and PH domains 2 2 2
MIRT669897 KIAA0754 KIAA0754 2 4
MIRT669983 SSR3 signal sequence receptor subunit 3 2 2
MIRT670160 SLC29A4 solute carrier family 29 member 4 2 2
MIRT670245 TRIM13 tripartite motif containing 13 2 2
MIRT670282 CBY3 chibby family member 3 2 2
MIRT670363 ULBP3 UL16 binding protein 3 2 4
MIRT670635 BVES blood vessel epicardial substance 2 2
MIRT670739 HOOK3 hook microtubule tethering protein 3 2 2
MIRT670778 TRIM66 tripartite motif containing 66 2 2
MIRT670921 DESI1 desumoylating isopeptidase 1 2 2
MIRT671374 TMPPE transmembrane protein with metallophosphoesterase domain 2 2
MIRT671406 ERCC6L2 ERCC excision repair 6 like 2 2 2
MIRT671436 TOX4 TOX high mobility group box family member 4 2 2
MIRT671661 TRUB2 TruB pseudouridine synthase family member 2 2 4
MIRT671718 PMPCA peptidase, mitochondrial processing alpha subunit 2 2
MIRT672043 SMTNL2 smoothelin like 2 2 2
MIRT672145 PLEKHH1 pleckstrin homology, MyTH4 and FERM domain containing H1 2 2
MIRT672406 SLC10A6 solute carrier family 10 member 6 2 2
MIRT672513 GGCX gamma-glutamyl carboxylase 2 2
MIRT672580 RNF24 ring finger protein 24 2 2
MIRT673207 C10orf76 chromosome 10 open reading frame 76 2 2
MIRT673380 ZNF124 zinc finger protein 124 2 2
MIRT673503 MCF2L2 MCF.2 cell line derived transforming sequence-like 2 2 6
MIRT673861 CAPN7 calpain 7 2 2
MIRT673935 ZNF500 zinc finger protein 500 2 2
MIRT673990 MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 2 2
MIRT674090 PLEKHA1 pleckstrin homology domain containing A1 2 2
MIRT674132 RPL7L1 ribosomal protein L7 like 1 2 2
MIRT674306 THAP5 THAP domain containing 5 2 2
MIRT674378 POLR3D RNA polymerase III subunit D 2 2
MIRT674650 NKRF NFKB repressing factor 2 2
MIRT674671 PLCE1 phospholipase C epsilon 1 2 2
MIRT674733 ZNF451 zinc finger protein 451 2 4
MIRT674787 NPR1 natriuretic peptide receptor 1 2 2
MIRT674901 RASSF9 Ras association domain family member 9 2 2
MIRT675025 SNX1 sorting nexin 1 2 2
MIRT675350 KLHL26 kelch like family member 26 2 2
MIRT675424 CLEC7A C-type lectin domain containing 7A 2 2
MIRT675505 HSD17B12 hydroxysteroid 17-beta dehydrogenase 12 2 2
MIRT675745 AHR aryl hydrocarbon receptor 2 2
MIRT675869 ATP1B4 ATPase Na+/K+ transporting family member beta 4 2 2
MIRT675999 CRKL CRK like proto-oncogene, adaptor protein 2 2
MIRT676221 TMEM91 transmembrane protein 91 2 2
MIRT677307 CPSF2 cleavage and polyadenylation specific factor 2 2 2
MIRT677838 TOR1AIP2 torsin 1A interacting protein 2 2 2
MIRT677876 ABI2 abl interactor 2 2 2
MIRT677974 ITGB3 integrin subunit beta 3 2 2
MIRT678184 CRCP CGRP receptor component 2 2
MIRT678282 PTRH2 peptidyl-tRNA hydrolase 2 2 2
MIRT679469 RHOF ras homolog family member F, filopodia associated 2 2
MIRT679521 RAB36 RAB36, member RAS oncogene family 2 2
MIRT679921 ZKSCAN3 zinc finger with KRAB and SCAN domains 3 2 2
MIRT680038 OSBPL2 oxysterol binding protein like 2 2 4
MIRT680254 NDUFA7 NADH:ubiquinone oxidoreductase subunit A7 2 2
MIRT680287 AKIP1 A-kinase interacting protein 1 2 2
MIRT680507 PRIM2 DNA primase subunit 2 2 2
MIRT680637 KIAA1456 KIAA1456 2 2
MIRT680827 ARL8B ADP ribosylation factor like GTPase 8B 2 2
MIRT680879 MAPK1IP1L mitogen-activated protein kinase 1 interacting protein 1 like 2 2
MIRT681006 AAED1 AhpC/TSA antioxidant enzyme domain containing 1 2 2
MIRT681128 INTS7 integrator complex subunit 7 2 2
MIRT681166 IBA57 IBA57 homolog, iron-sulfur cluster assembly 2 2
MIRT681228 DUSP19 dual specificity phosphatase 19 2 2
MIRT681311 IKZF3 IKAROS family zinc finger 3 2 2
MIRT681348 BRI3BP BRI3 binding protein 2 2
MIRT681615 F2RL2 coagulation factor II thrombin receptor like 2 2 2
MIRT681785 EIF4A3 eukaryotic translation initiation factor 4A3 2 2
MIRT681898 SLC11A2 solute carrier family 11 member 2 2 2
MIRT682091 ITGA3 integrin subunit alpha 3 2 4
MIRT682144 SMS spermine synthase 2 2
MIRT682170 SLC38A7 solute carrier family 38 member 7 2 2
MIRT682227 SAR1A secretion associated Ras related GTPase 1A 2 2
MIRT682350 PLEKHB2 pleckstrin homology domain containing B2 2 2
MIRT682374 PHACTR4 phosphatase and actin regulator 4 2 2
MIRT682543 EXOSC2 exosome component 2 2 2
MIRT682628 COX6B1 cytochrome c oxidase subunit 6B1 2 2
MIRT683549 HAVCR1 hepatitis A virus cellular receptor 1 2 2
MIRT683650 ZNF695 zinc finger protein 695 2 2
MIRT684449 MFSD4 major facilitator superfamily domain containing 4A 2 2
MIRT684863 ZNF749 zinc finger protein 749 2 2
MIRT684963 MINOS1 mitochondrial inner membrane organizing system 1 2 2
MIRT685054 GEMIN4 gem nuclear organelle associated protein 4 2 2
MIRT685102 DTD2 D-tyrosyl-tRNA deacylase 2 (putative) 2 2
MIRT685817 SLC27A1 solute carrier family 27 member 1 2 2
MIRT685918 MOCS3 molybdenum cofactor synthesis 3 2 2
MIRT686672 TMEM120B transmembrane protein 120B 2 2
MIRT687125 QPCTL glutaminyl-peptide cyclotransferase like 2 2
MIRT687746 KIAA1328 KIAA1328 2 2
MIRT688069 GLUL glutamate-ammonia ligase 2 2
MIRT688776 CDH7 cadherin 7 2 2
MIRT688949 ATXN3 ataxin 3 2 2
MIRT689691 TMPRSS12 transmembrane protease, serine 12 2 2
MIRT689746 PRR13 proline rich 13 2 2
MIRT689942 MANSC1 MANSC domain containing 1 2 2
MIRT690099 PNMA2 paraneoplastic Ma antigen 2 2 2
MIRT690197 C5orf45 MRN complex interacting protein 2 2
MIRT690255 CAMLG calcium modulating ligand 2 2
MIRT690426 FAM71F2 family with sequence similarity 71 member F2 2 2
MIRT691118 ADIPOQ adiponectin, C1Q and collagen domain containing 2 2
MIRT691238 DFNB59 pejvakin 2 2
MIRT691305 ZNF681 zinc finger protein 681 2 2
MIRT691374 GP5 glycoprotein V platelet 2 2
MIRT691809 WARS tryptophanyl-tRNA synthetase 2 2
MIRT692153 CEP104 centrosomal protein 104 2 2
MIRT692354 AGTRAP angiotensin II receptor associated protein 2 2
MIRT692582 NCMAP non-compact myelin associated protein 2 2
MIRT692656 ZMYM1 zinc finger MYM-type containing 1 2 2
MIRT692752 NDUFS5 NADH:ubiquinone oxidoreductase subunit S5 2 2
MIRT693101 SCNM1 sodium channel modifier 1 2 2
MIRT693261 HBS1L HBS1 like translational GTPase 2 2
MIRT693303 SYTL3 synaptotagmin like 3 2 2
MIRT693396 ZNF460 zinc finger protein 460 2 2
MIRT693494 MOB3A MOB kinase activator 3A 2 2
MIRT693541 ZNF708 zinc finger protein 708 2 2
MIRT693569 PIGR polymeric immunoglobulin receptor 2 2
MIRT694496 AGBL5 ATP/GTP binding protein like 5 2 2
MIRT694741 LLGL1 LLGL1, scribble cell polarity complex component 2 2
MIRT694872 ZNF417 zinc finger protein 417 2 2
MIRT695079 ZNF17 zinc finger protein 17 2 2
MIRT695462 COX18 COX18, cytochrome c oxidase assembly factor 2 2
MIRT695730 ZNF117 zinc finger protein 117 2 2
MIRT695905 MED16 mediator complex subunit 16 2 2
MIRT696268 TACO1 translational activator of cytochrome c oxidase I 2 2
MIRT696519 C3 complement C3 2 2
MIRT696570 TTC21B tetratricopeptide repeat domain 21B 2 2
MIRT696652 AGXT2 alanine--glyoxylate aminotransferase 2 2 2
MIRT696798 DHODH dihydroorotate dehydrogenase (quinone) 2 2
MIRT696828 PLLP plasmolipin 2 2
MIRT696972 CCDC80 coiled-coil domain containing 80 2 2
MIRT697092 GPKOW G-patch domain and KOW motifs 2 2
MIRT697170 INMT indolethylamine N-methyltransferase 2 2
MIRT697213 ZYG11A zyg-11 family member A, cell cycle regulator 2 2
MIRT697339 ZNF641 zinc finger protein 641 2 2
MIRT697589 YME1L1 YME1 like 1 ATPase 2 2
MIRT698626 TES testin LIM domain protein 2 2
MIRT698957 SPAST spastin 2 2
MIRT699091 SNRPD3 small nuclear ribonucleoprotein D3 polypeptide 2 2
MIRT699439 SLC1A5 solute carrier family 1 member 5 2 2
MIRT699561 SIT1 signaling threshold regulating transmembrane adaptor 1 2 2
MIRT700333 RAB4A RAB4A, member RAS oncogene family 2 2
MIRT700365 RAB33B RAB33B, member RAS oncogene family 2 2
MIRT700466 PURB purine rich element binding protein B 2 2
MIRT701687 MYADM myeloid associated differentiation marker 2 2
MIRT701765 MSL2 MSL complex subunit 2 2 2
MIRT703186 GPBP1 GC-rich promoter binding protein 1 2 2
MIRT703213 GOLGA3 golgin A3 2 2
MIRT703369 GAPVD1 GTPase activating protein and VPS9 domains 1 2 2
MIRT703433 FYTTD1 forty-two-three domain containing 1 2 2
MIRT703609 FBXO45 F-box protein 45 2 2
MIRT703708 FAM134A reticulophagy regulator family member 2 2 2
MIRT703818 EVI5 ecotropic viral integration site 5 2 2
MIRT703922 EPG5 ectopic P-granules autophagy protein 5 homolog 2 2
MIRT704242 DHDDS dehydrodolichyl diphosphate synthase subunit 2 2
MIRT704653 CLCC1 chloride channel CLIC like 1 2 2
MIRT704939 CCDC120 coiled-coil domain containing 120 2 2
MIRT705168 C11orf58 chromosome 11 open reading frame 58 2 2
MIRT705538 ARL10 ADP ribosylation factor like GTPase 10 2 2
MIRT705668 ANKRD40 ankyrin repeat domain 40 2 2
MIRT706151 ZNF674 zinc finger protein 674 2 2
MIRT706480 SNX27 sorting nexin family member 27 2 2
MIRT708784 CD200R1 CD200 receptor 1 2 2
MIRT708845 SCAND3 zinc finger BED-type containing 9 1 1
MIRT709844 SNX12 sorting nexin 12 2 2
MIRT710445 BTNL3 butyrophilin like 3 2 2
MIRT711092 OGG1 8-oxoguanine DNA glycosylase 4 2
MIRT711334 DPYSL5 dihydropyrimidinase like 5 2 2
MIRT713369 STK35 serine/threonine kinase 35 2 2
MIRT717125 SOWAHA sosondowah ankyrin repeat domain family member A 2 2
MIRT717408 ZCCHC24 zinc finger CCHC-type containing 24 2 2
MIRT722232 ZNF503 zinc finger protein 503 2 2
MIRT722670 RRM2 ribonucleotide reductase regulatory subunit M2 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-4728 Cisplatin 5460033 NSC119875 approved sensitive High Gastric Cancer cell line (SGC7901)
hsa-mir-4728 Doxorubicin 31703 NSC123127 approved sensitive High Gastric Cancer cell line (SGC7901)
hsa-mir-4728 Fluorouracil 3385 NSC19893 approved sensitive High Gastric Cancer cell line (SGC7901)
hsa-mir-4728 Vincristine 5978 approved sensitive High Gastric Cancer cell line (SGC7901)
hsa-mir-4728 Tamoxifen 2733525 NSC180973 approved resistant High Breast Cancer cell line (MCF-7)
hsa-mir-4728 Androstenedione 6128 NSC9563 sensitive cell line (MCF-7)
hsa-mir-4728 Androstenedione+Anastrozole sensitive cell line (MCF-7)
hsa-mir-4728 Tamoxifen 2733525 NSC180973 approved resistant cell line (MCF7)
hsa-mir-4728 Cisplatin 5460033 NSC119875 approved resistant cell line (BxPC3)
hsa-miR-4728-5p Fluorouracil 3385 NSC19893 approved resistant High Pancreatic Cancer cell line (PATU8988)
hsa-miR-4728-5p Cisplatin 5460033 NSC119875 approved resistant High Hypopharyngeal Cancer cell line (FaDu)
hsa-miR-4728-5p Temozolomide 5394 NSC362856 approved resistant cell line (U251)
hsa-miR-4728-5p Gefitinib 123631 NSC715055 approved resistant cell line (PC9)
hsa-miR-4728-5p Osimertinib 71496458 NSC779217 approved resistant cell line (HCC827)
hsa-miR-4728-5p Osimertinib 71496458 NSC779217 approved resistant cell line (H1975)
hsa-miR-4728-5p Cisplatin 5460033 NSC119875 approved resistant cell line (A2780)
hsa-miR-4728-5p Vemurafenib 42611257 NSC761431 approved sensitive cell line (LM16)
hsa-miR-4728-5p Gemcitabine 60750 NSC613327 approved resistant cell line (Panc1-GR4)

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