miRTarBase - #MIRT452717


—
pre-miRNA Information
pre-miRNA hsa-mir-4270   
Genomic Coordinates chr3: 15496239 - 15496308
Description Homo sapiens miR-4270 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-4270
Sequence 11| UCAGGGAGUCAGGGGAGGGC |30
Evidence Experimental
Experiments SOLiD
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs991570490 2 dbSNP
rs1417709982 10 dbSNP
rs960511282 12 dbSNP
rs928808979 14 dbSNP
rs1372156971 15 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol DTHD1   
Synonyms -
Description death domain containing 1
Transcript NM_001136536   
Other Transcripts NM_001170700   
Expression
Putative miRNA Targets on DTHD1
3'UTR of DTHD1
(miRNA target sites are highlighted)		 
>DTHD1|NM_001136536|3'UTR
   1 AAGCCTGATCTCTCTTCCTTTACCCCTAGGAAAAGGCACACGGTGGGTTTTTGTTTCTGTCAACATTTTCCTGGAAGTTT
  81 CCGAATGATATTATTTGAAGTCAGTCTATTTAATGATGTGCTATTTAATGATGTGAGACAAAGGGAGAAGCACGGATCAG
 161 ATAATAGAAAGCATTCCTGGGTGTGAGCGCTCCTCTCTGGTTGAGTGATTATGTTTTGCAACCATGACTGTCTTGAGTTT
 241 GGCCTCACTTAATAGCATTTGCAATTGAGTTTGACTTGTTCACATTTTAAAAGCTAAGTGTGAAGAAAAGATCTGATATA
 321 TGTAATTACTTATTAATTGGTATCTACATAAAATTAAACTAGTTTTCTGTGACTTCAAGTGTGAGCCCAAAAATATCTGA
 401 GACAGTTCTCAATCAATTTAGAAAGATTATTTTGCCAAGGTTAAGGACAGGCCCGTAACAGCCTCAGAAGATCCTGATGA
 481 CATATGCCCAAGGTGTTCGGGGTAGAGCTTGCTTTTATGCATTTTAGGGAGTTATAATATATCAATCAATACATGTAAGG
 561 TGTACATTGGCTCAATCTGGAAAGGTAGGACAACTCAAAGCAGGGGCTTCCAGATCACAGGTAGATTTAAAGATTCTTGA
 641 TTGGCATTGATTGAACAGTTATTATCTAAAGACCTGGAATCAATAGGAAGGAAATGCCTGGGCTATGATAAGAAGTTATG
 721 GAGACCAAAGTTTTATAATGCAGATGAAGCCTCCAGGTAGCAGACTTTAGAGGGAATAGATTGTAAATATTTCTGATCAG
 801 TCCTAAGGTCTGTTGAAATTTATGCTGGCCAGCTTTTCCTGAATTCCAAAAGAGAGGAGGGTATTATGGAGTCATGTCCA
 881 ACCTCCCCTTCCCAGCATGGCCTAAACTAGTTTTTCAGGATAACTTTGAAATGCCCTTGGCTGAGAGAAGGGGCTTGTTC
 961 A
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' cgggagGGGACUGAGGGACu 5'
                | ||  |||:||| 
Target 5' tgtgagCGCT-CCTCTCTGg 3'
 182 - 200 125.00 -15.20
2 
miRNA  3' cgggaggGGACU-GAGGGAcu 5'
                 ||||| |||:||  
Target 5' ----aagCCTGATCTCTCTtc 3'
 1 - 17 121.00 -14.10
3 
miRNA  3' cgGGAGGGGACUGAGGGACu 5'
            |||||||   :|||| | 
Target 5' aaCCTCCCC---TTCCCAGc 3'
 880 - 896 115.00 -20.62
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30692130 54 COSMIC
COSN30727523 88 COSMIC
COSN20060903 113 COSMIC
COSN17714782 155 COSMIC
COSN4835573 417 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs778328734 8 dbSNP
rs1401803246 13 dbSNP
rs944353282 15 dbSNP
rs1298090998 19 dbSNP
rs747535137 25 dbSNP
rs1388893568 31 dbSNP
rs1205367941 35 dbSNP
rs190538762 37 dbSNP
rs148599548 38 dbSNP
rs1195412624 40 dbSNP
rs1221889689 42 dbSNP
rs1280225242 43 dbSNP
rs551839788 44 dbSNP
rs1432463815 46 dbSNP
rs970441618 47 dbSNP
rs1250707775 49 dbSNP
rs1252910359 57 dbSNP
rs1484252569 83 dbSNP
rs1180309982 84 dbSNP
rs904648549 89 dbSNP
rs758408411 106 dbSNP
rs936105359 109 dbSNP
rs1199333860 114 dbSNP
rs570142517 122 dbSNP
rs1413390845 124 dbSNP
rs534338675 135 dbSNP
rs1424466240 141 dbSNP
rs1167075254 146 dbSNP
rs977837757 149 dbSNP
rs552899683 154 dbSNP
rs1357433916 173 dbSNP
rs957849778 181 dbSNP
rs1427665567 187 dbSNP
rs370076682 189 dbSNP
rs536902622 190 dbSNP
rs1014244570 204 dbSNP
rs750325224 210 dbSNP
rs13118055 224 dbSNP
rs911913736 225 dbSNP
rs576698568 226 dbSNP
rs1300683108 228 dbSNP
rs1404675337 231 dbSNP
rs940741822 232 dbSNP
rs1164779424 239 dbSNP
rs1468850956 242 dbSNP
rs1378082655 244 dbSNP
rs1282081650 247 dbSNP
rs1179340366 266 dbSNP
rs1441577597 270 dbSNP
rs993777528 273 dbSNP
rs543965222 274 dbSNP
rs1036415837 284 dbSNP
rs565402266 298 dbSNP
rs1316464007 299 dbSNP
rs1027496992 303 dbSNP
rs577380517 306 dbSNP
rs1203701841 311 dbSNP
rs1351062396 315 dbSNP
rs951943121 322 dbSNP
rs1228244635 323 dbSNP
rs550002099 327 dbSNP
rs1378537681 333 dbSNP
rs1300587168 335 dbSNP
rs930825629 343 dbSNP
rs541448728 345 dbSNP
rs1208542970 348 dbSNP
rs1325292534 354 dbSNP
rs1398667034 370 dbSNP
rs1360168241 378 dbSNP
rs1237104652 379 dbSNP
rs559655222 380 dbSNP
rs1421725720 381 dbSNP
rs1393387008 382 dbSNP
rs1014938025 383 dbSNP
rs113724754 384 dbSNP
rs550067913 388 dbSNP
rs1248898127 403 dbSNP
rs1191531269 426 dbSNP
rs975714870 429 dbSNP
rs529991307 431 dbSNP
rs922897666 433 dbSNP
rs1275967416 440 dbSNP
rs906206507 442 dbSNP
rs1218069567 449 dbSNP
rs1345632312 450 dbSNP
rs946306637 453 dbSNP
rs999225192 455 dbSNP
rs1339650340 456 dbSNP
rs1298544153 460 dbSNP
rs548457253 475 dbSNP
rs183079292 476 dbSNP
rs868108894 483 dbSNP
rs1448963875 488 dbSNP
rs1030751612 494 dbSNP
rs958049009 496 dbSNP
rs1010724254 497 dbSNP
rs530598669 499 dbSNP
rs936141869 500 dbSNP
rs1029254957 513 dbSNP
rs1427900318 521 dbSNP
rs1357944756 528 dbSNP
rs779769249 530 dbSNP
rs1477763093 532 dbSNP
rs953299655 534 dbSNP
rs1264431990 536 dbSNP
rs987798129 537 dbSNP
rs1196286269 540 dbSNP
rs911861450 546 dbSNP
rs1235316981 550 dbSNP
rs1208852214 560 dbSNP
rs962013699 561 dbSNP
rs748945149 564 dbSNP
rs1280097695 569 dbSNP
rs1055907005 575 dbSNP
rs1358380870 589 dbSNP
rs551924917 594 dbSNP
rs972078871 617 dbSNP
rs920662186 621 dbSNP
rs1377288484 632 dbSNP
rs570228706 637 dbSNP
rs1449008973 650 dbSNP
rs1055939973 654 dbSNP
rs534373954 663 dbSNP
rs1326930717 665 dbSNP
rs916065705 665 dbSNP
rs1465614474 669 dbSNP
rs879426291 678 dbSNP
rs1173282201 685 dbSNP
rs950295282 693 dbSNP
rs768261179 697 dbSNP
rs993442896 698 dbSNP
rs1180972804 699 dbSNP
rs1046006448 715 dbSNP
rs1483354501 716 dbSNP
rs1238766358 731 dbSNP
rs1196191325 733 dbSNP
rs878920985 734 dbSNP
rs778614824 737 dbSNP
rs999170945 738 dbSNP
rs1258553848 752 dbSNP
rs1200334767 759 dbSNP
rs1233516111 760 dbSNP
rs1052126859 774 dbSNP
rs1433762410 778 dbSNP
rs893525244 790 dbSNP
rs73121679 796 dbSNP
rs1307196915 800 dbSNP
rs1364767474 806 dbSNP
rs1028788555 808 dbSNP
rs1333895066 812 dbSNP
rs1456820160 814 dbSNP
rs953344633 828 dbSNP
rs568043287 829 dbSNP
rs1007794267 847 dbSNP
rs1424086735 860 dbSNP
rs1017344143 862 dbSNP
rs1415434288 862 dbSNP
rs965766929 863 dbSNP
rs111371105 868 dbSNP
rs1313184479 876 dbSNP
rs1008721616 884 dbSNP
rs1264699943 886 dbSNP
rs966747399 911 dbSNP
rs1018815004 929 dbSNP
rs961959753 935 dbSNP
rs1266526559 936 dbSNP
rs1323737707 939 dbSNP
rs1284102651 940 dbSNP
rs1239542677 942 dbSNP
rs1377804306 946 dbSNP
rs536582571 950 dbSNP
rs762674695 950 dbSNP
rs972026653 958 dbSNP
rs1367494834 960 dbSNP
rs1294500023 961 dbSNP
rs977718667 962 dbSNP
rs370911713 967 dbSNP
rs771580698 968 dbSNP
rs926177834 970 dbSNP
rs1418687531 971 dbSNP
rs952123711 972 dbSNP
rs555225808 978 dbSNP
rs957588476 982 dbSNP
rs1476320870 984 dbSNP
rs879665938 989 dbSNP
rs991990306 991 dbSNP
rs773884662 999 dbSNP
rs1424162807 1020 dbSNP
rs1414871934 1022 dbSNP
rs1489310751 1022 dbSNP
rs916036491 1023 dbSNP
rs761213359 1025 dbSNP
rs1156232235 1032 dbSNP
rs1231081348 1035 dbSNP
rs916030961 1043 dbSNP
rs1386079408 1044 dbSNP
rs1456232613 1046 dbSNP
rs950261689 1048 dbSNP
rs1338960547 1050 dbSNP
rs1320572521 1052 dbSNP
rs1399079372 1083 dbSNP
rs981628229 1084 dbSNP
rs1346460540 1092 dbSNP
rs1159799705 1095 dbSNP
rs532613168 1101 dbSNP
rs1377025839 1103 dbSNP
rs766308173 1109 dbSNP
rs1045819534 1110 dbSNP
rs78387147 1115 dbSNP
rs1481358723 1116 dbSNP
rs188163500 1122 dbSNP
rs1368723159 1124 dbSNP
rs1225779918 1127 dbSNP
rs1052075956 1130 dbSNP
rs1198829548 1135 dbSNP
rs1286677202 1139 dbSNP
rs1328816623 1140 dbSNP
rs777066944 1141 dbSNP
rs1256637046 1154 dbSNP
rs893467461 1161 dbSNP
rs759936741 1162 dbSNP
rs919278540 1167 dbSNP
rs1286355333 1170 dbSNP
rs1050593482 1171 dbSNP
rs1219559205 1180 dbSNP
rs765431662 1187 dbSNP
rs1319829449 1190 dbSNP
rs1049001653 1193 dbSNP
rs552613598 1194 dbSNP
rs770540654 1202 dbSNP
rs1018762396 1204 dbSNP
rs897719318 1209 dbSNP
rs775754177 1211 dbSNP
rs1169701307 1213 dbSNP
rs566071238 1220 dbSNP
rs901653464 1224 dbSNP
rs1185740138 1227 dbSNP
rs147954636 1228 dbSNP
rs952132597 1229 dbSNP
rs1205577254 1233 dbSNP
rs1456831249 1235 dbSNP
rs141895772 1240 dbSNP
rs1257937576 1251 dbSNP
rs762979147 1255 dbSNP
rs1320508880 1267 dbSNP
rs1242236022 1284 dbSNP
rs1339492691 1294 dbSNP
rs1409500530 1296 dbSNP
rs9918030 1305 dbSNP
rs747599581 1316 dbSNP
rs750376641 1319 dbSNP
rs541513510 1324 dbSNP
rs1398452003 1326 dbSNP
rs1409469826 1327 dbSNP
rs924790682 1328 dbSNP
rs1472599826 1329 dbSNP
rs934859068 1331 dbSNP
rs1185537392 1340 dbSNP
rs1437856596 1343 dbSNP
rs1237619186 1348 dbSNP
rs755980265 1350 dbSNP
rs990410342 1352 dbSNP
rs914864482 1355 dbSNP
rs17460694 1359 dbSNP
rs1050121718 1371 dbSNP
rs888850535 1377 dbSNP
rs1292000446 1384 dbSNP
rs574761649 1393 dbSNP
rs76696413 1398 dbSNP
rs1374079925 1404 dbSNP
rs1307895816 1412 dbSNP
rs1447500351 1420 dbSNP
rs1040160629 1421 dbSNP
rs897670235 1424 dbSNP
rs1227877679 1430 dbSNP
rs1404512448 1436 dbSNP
rs79909805 1437 dbSNP
rs1490475375 1443 dbSNP
rs530682505 1447 dbSNP
rs1249298512 1448 dbSNP
rs1159312064 1456 dbSNP
rs1245416988 1457 dbSNP
rs1198636103 1459 dbSNP
rs1027982248 1470 dbSNP
rs887724224 1476 dbSNP
rs1482617102 1477 dbSNP
rs981548101 1482 dbSNP
rs551961910 1491 dbSNP
rs754780843 1492 dbSNP
rs1223790929 1522 dbSNP
rs971446842 1526 dbSNP
rs1385328734 1533 dbSNP
rs1435649597 1538 dbSNP
rs909177699 1540 dbSNP
rs1304724492 1547 dbSNP
rs1427035428 1550 dbSNP
rs1360067618 1552 dbSNP
rs981525238 1560 dbSNP
rs1216119933 1566 dbSNP
rs1167303831 1581 dbSNP
rs943291452 1583 dbSNP
rs1423711046 1585 dbSNP
rs1172554394 1586 dbSNP
rs759502028 1593 dbSNP
rs901700907 1594 dbSNP
rs1392388495 1596 dbSNP
rs997284022 1610 dbSNP
rs1338983514 1613 dbSNP
rs1261969255 1621 dbSNP
rs1447587131 1622 dbSNP
rs1031811687 1630 dbSNP
rs1361721571 1635 dbSNP
rs1215919905 1636 dbSNP
rs1448280348 1640 dbSNP
rs956186835 1641 dbSNP
rs990375461 1648 dbSNP
rs572604655 1677 dbSNP
rs1218645012 1678 dbSNP
rs563890870 1682 dbSNP
rs376052820 1683 dbSNP
rs986172306 1688 dbSNP
rs546663699 1697 dbSNP
rs1216494330 1706 dbSNP
rs1340155086 1707 dbSNP
rs1289616427 1708 dbSNP
rs910237839 1710 dbSNP
rs1357539646 1712 dbSNP
rs1333585342 1720 dbSNP
rs944421875 1723 dbSNP
rs902251926 1725 dbSNP
rs190801968 1732 dbSNP
rs919047473 1733 dbSNP
rs182653038 1734 dbSNP
rs1454713393 1736 dbSNP
rs202228435 1742 dbSNP
rs10035051 1743 dbSNP
rs200436805 1745 dbSNP
rs10000657 1746 dbSNP
rs894776976 1747 dbSNP
rs537695180 1748 dbSNP
rs1012853755 1749 dbSNP
rs1187206854 1750 dbSNP
rs1317122401 1751 dbSNP
rs1023205453 1754 dbSNP
rs1216614215 1770 dbSNP
rs1390171123 1772 dbSNP
rs971586045 1774 dbSNP
rs11947968 1777 dbSNP
rs1385650470 1799 dbSNP
rs1453418492 1799 dbSNP
rs1329979982 1808 dbSNP
rs1465538391 1813 dbSNP
rs907209098 1817 dbSNP
rs868029233 1818 dbSNP
rs1172976017 1821 dbSNP
rs1411310423 1822 dbSNP
rs1411091508 1831 dbSNP
rs1180801283 1832 dbSNP
rs950867652 1838 dbSNP
rs1002910066 1839 dbSNP
rs868772280 1840 dbSNP
rs1031759247 1841 dbSNP
rs1400518512 1853 dbSNP
rs1414080750 1864 dbSNP
rs1457258273 1869 dbSNP
rs1251731518 1870 dbSNP
rs956132770 1877 dbSNP
rs758001811 1892 dbSNP
rs571049026 1898 dbSNP
rs943347883 1900 dbSNP
rs1433038298 1923 dbSNP
rs1246960350 1934 dbSNP
rs974652839 1935 dbSNP
rs1307177485 1970 dbSNP
rs1295309414 1979 dbSNP
rs1446772505 1980 dbSNP
rs777359622 1981 dbSNP
rs1364445028 1985 dbSNP
rs923177056 1991 dbSNP
rs933188213 1996 dbSNP
rs1434708999 1997 dbSNP
rs1042610532 2016 dbSNP
rs1021809767 2025 dbSNP
rs534841798 2026 dbSNP
rs954419854 2027 dbSNP
rs747519461 2029 dbSNP
rs771630370 2030 dbSNP
rs1053517398 2035 dbSNP
rs1342652990 2040 dbSNP
rs1199480317 2043 dbSNP
rs1251107128 2045 dbSNP
rs894828447 2050 dbSNP
rs1487411944 2054 dbSNP
rs1011907012 2057 dbSNP
rs1023257501 2059 dbSNP
rs1263430399 2067 dbSNP
rs1462247866 2083 dbSNP
rs1206341816 2089 dbSNP
rs907452750 2093 dbSNP
rs965679637 2099 dbSNP
rs147083162 2114 dbSNP
rs1309721594 2117 dbSNP
rs1026909021 2119 dbSNP
rs866196366 2135 dbSNP
rs918991860 2139 dbSNP
rs929084274 2149 dbSNP
rs1195989126 2154 dbSNP
rs1304126184 2173 dbSNP
rs1049344472 2174 dbSNP
rs1385502448 2175 dbSNP
rs985296273 2178 dbSNP
rs1016329899 2179 dbSNP
rs909048648 2189 dbSNP
rs11944273 2190 dbSNP
rs964708128 2192 dbSNP
rs1376232453 2195 dbSNP
rs192693497 2199 dbSNP
rs151082989 2201 dbSNP
rs183163117 2214 dbSNP
rs1408659826 2217 dbSNP
rs923229515 2220 dbSNP
rs933240714 2221 dbSNP
rs1262535947 2235 dbSNP
rs1312109101 2238 dbSNP
rs1284340338 2243 dbSNP
rs1455700419 2247 dbSNP
rs1225692041 2249 dbSNP
rs978001094 2250 dbSNP
rs187487324 2253 dbSNP
rs1381275291 2257 dbSNP
rs1002856360 2259 dbSNP
rs1053975083 2261 dbSNP
rs1464497122 2263 dbSNP
rs1385771541 2269 dbSNP
rs1053138380 2271 dbSNP
rs891859703 2276 dbSNP
rs1011682055 2279 dbSNP
rs1481266237 2282 dbSNP
rs141053669 2284 dbSNP
rs1192794026 2285 dbSNP
rs1429333072 2287 dbSNP
rs1198741715 2289 dbSNP
rs1329120112 2293 dbSNP
rs889969822 2302 dbSNP
rs746263901 2303 dbSNP
rs770158434 2305 dbSNP
rs947742463 2306 dbSNP
rs1206101372 2312 dbSNP
rs1007508362 2316 dbSNP
rs1046100586 2317 dbSNP
rs1019803999 2319 dbSNP
rs1283506473 2321 dbSNP
rs1226316162 2325 dbSNP
rs1326598235 2328 dbSNP
rs1297110465 2330 dbSNP
rs866943370 2331 dbSNP
rs1003548066 2332 dbSNP
rs965626250 2334 dbSNP
rs545688597 2346 dbSNP
rs975688890 2347 dbSNP
rs775601432 2348 dbSNP
rs763180086 2349 dbSNP
rs1167092239 2350 dbSNP
rs1006378500 2356 dbSNP
rs118025508 2382 dbSNP
rs770019983 2383 dbSNP
rs1485920892 2388 dbSNP
rs1207385303 2390 dbSNP
rs774482041 2398 dbSNP
rs984564474 2405 dbSNP
rs1272761979 2408 dbSNP
rs1196684179 2409 dbSNP
rs1451388857 2415 dbSNP
rs28454640 2419 dbSNP
rs1030297962 2420 dbSNP
rs1252648194 2420 dbSNP
rs996179163 2420 dbSNP
rs948579544 2421 dbSNP
rs954681481 2427 dbSNP
rs1471696233 2431 dbSNP
rs1374493818 2433 dbSNP
rs979956384 2434 dbSNP
rs1158747325 2435 dbSNP
rs1327943289 2441 dbSNP
rs113337077 2450 dbSNP
rs1398337954 2452 dbSNP
rs1161720565 2454 dbSNP
rs938596413 2460 dbSNP
rs923867962 2465 dbSNP
rs958143943 2466 dbSNP
rs112872316 2470 dbSNP
rs1053086467 2473 dbSNP
rs916376956 2475 dbSNP
rs891799547 2477 dbSNP
rs947791696 2480 dbSNP
rs1404268973 2485 dbSNP
rs947426165 2490 dbSNP
rs927630425 2493 dbSNP
rs1490080195 2503 dbSNP
rs76856595 2504 dbSNP
rs372774314 2510 dbSNP
rs1278938107 2512 dbSNP
rs753777934 2516 dbSNP
rs576931373 2526 dbSNP
rs1321325583 2527 dbSNP
rs1264190093 2530 dbSNP
rs1366358905 2535 dbSNP
rs1305070142 2540 dbSNP
rs1006841184 2542 dbSNP
rs201411817 2553 dbSNP
rs1407317735 2564 dbSNP
rs1159689643 2570 dbSNP
rs1271448433 2575 dbSNP
rs550556520 2581 dbSNP
rs1471438062 2591 dbSNP
rs1376339777 2592 dbSNP
rs1181706634 2596 dbSNP
rs901409856 2597 dbSNP
rs1490085254 2598 dbSNP
rs1037838655 2605 dbSNP
rs1420956482 2624 dbSNP
rs994381270 2637 dbSNP
rs1025901367 2648 dbSNP
rs1352682397 2652 dbSNP
rs996230091 2659 dbSNP
rs141945715 2662 dbSNP
rs1030350232 2667 dbSNP
rs1285489288 2669 dbSNP
rs1398346287 2672 dbSNP
rs765030604 2677 dbSNP
rs1319048875 2685 dbSNP
rs531274452 2688 dbSNP
rs552889329 2689 dbSNP
rs145655787 2690 dbSNP
rs1164153532 2693 dbSNP
rs1367180595 2694 dbSNP
rs1031374606 2695 dbSNP
rs1287291398 2698 dbSNP
rs193040320 2703 dbSNP
rs1373679500 2708 dbSNP
rs970240974 2709 dbSNP
rs1431866187 2711 dbSNP
rs535244144 2713 dbSNP
rs1392787981 2720 dbSNP
rs979903861 2727 dbSNP
rs1241032960 2730 dbSNP
rs553258400 2732 dbSNP
rs777561506 2743 dbSNP
rs1202937853 2752 dbSNP
rs1247290779 2754 dbSNP
rs746571182 2758 dbSNP
rs1294653730 2766 dbSNP
rs916428726 2767 dbSNP
rs1264762660 2774 dbSNP
rs138746265 2777 dbSNP
rs535532935 2781 dbSNP
rs1361458380 2783 dbSNP
rs1270848859 2788 dbSNP
rs16992129 2790 dbSNP
rs1252100128 2792 dbSNP
rs144742746 2794 dbSNP
rs781584717 2808 dbSNP
rs1336703786 2811 dbSNP
rs913175718 2814 dbSNP
rs1408833500 2820 dbSNP
rs927687687 2821 dbSNP
rs929667314 2832 dbSNP
rs947389742 2833 dbSNP
rs1481700565 2842 dbSNP
rs1043478156 2843 dbSNP
rs889846949 2851 dbSNP
rs942803904 2854 dbSNP
rs1244757706 2855 dbSNP
rs1041157209 2861 dbSNP
rs901357526 2862 dbSNP
rs575223195 2863 dbSNP
rs1184095093 2867 dbSNP
rs1037889546 2891 dbSNP
rs373215638 2897 dbSNP
rs1387082097 2899 dbSNP
rs376265733 2921 dbSNP
rs1427567368 2929 dbSNP
rs1296843608 2940 dbSNP
rs1355459362 2956 dbSNP
rs1169410788 2964 dbSNP
rs900698559 2969 dbSNP
rs1354902619 2978 dbSNP
rs1047300015 2985 dbSNP
rs1445168452 2987 dbSNP
rs1386968539 2993 dbSNP
rs888721405 3007 dbSNP
rs1175287588 3012 dbSNP
rs1463163903 3019 dbSNP
rs1300740692 3020 dbSNP
rs1233213327 3031 dbSNP
rs1051830945 3037 dbSNP
rs1489904637 3038 dbSNP
rs1005873022 3040 dbSNP
rs1317776372 3046 dbSNP
rs189663416 3050 dbSNP
rs1016356958 3057 dbSNP
rs369121120 3058 dbSNP
rs766541120 3062 dbSNP
rs192350906 3066 dbSNP
rs1223690055 3090 dbSNP
rs1296682852 3091 dbSNP
rs1309653453 3092 dbSNP
rs1001290361 3093 dbSNP
rs1374596631 3097 dbSNP
rs1208251073 3098 dbSNP
rs1035490305 3104 dbSNP
rs13138014 3111 dbSNP
rs573022768 3112 dbSNP
rs1363253609 3114 dbSNP
rs1302019012 3122 dbSNP
rs1424686067 3124 dbSNP
rs913133321 3132 dbSNP
rs1351092196 3136 dbSNP
rs1199244016 3137 dbSNP
rs893768476 3142 dbSNP
rs770069978 3147 dbSNP
rs1281242597 3150 dbSNP
rs572884512 3153 dbSNP
rs978759528 3155 dbSNP
rs2279783 3158 dbSNP
rs1268391464 3164 dbSNP
rs1223478708 3168 dbSNP
rs1490873694 3173 dbSNP
rs942753295 3186 dbSNP
rs183934349 3189 dbSNP
rs1215771265 3198 dbSNP
rs1317982647 3201 dbSNP
rs1309607918 3204 dbSNP
rs1041100472 3205 dbSNP
rs1343278583 3210 dbSNP
rs1282293972 3215 dbSNP
rs1034808217 3216 dbSNP
rs951166488 3219 dbSNP
rs1404990074 3222 dbSNP
rs922727774 3224 dbSNP
rs567391645 3227 dbSNP
rs1161132979 3228 dbSNP
rs1468085820 3235 dbSNP
rs1338064266 3247 dbSNP
rs112748315 3248 dbSNP
rs767521750 3264 dbSNP
rs34757626 3266 dbSNP
rs1486495670 3276 dbSNP
rs1262961741 3281 dbSNP
rs1271331766 3282 dbSNP
rs1202305938 3283 dbSNP
rs888676838 3292 dbSNP
rs1264137777 3295 dbSNP
rs1223763885 3303 dbSNP
rs973649176 3304 dbSNP
rs1292863640 3306 dbSNP
rs1381117590 3311 dbSNP
rs1217899751 3312 dbSNP
rs188262954 3313 dbSNP
rs932191475 3330 dbSNP
rs1405161390 3335 dbSNP
rs1037333934 3338 dbSNP
rs1051881087 3339 dbSNP
rs6819595 3344 dbSNP
rs1001236684 3345 dbSNP
rs935441797 3354 dbSNP
rs1052923100 3356 dbSNP
rs893829355 3358 dbSNP
rs1010896317 3367 dbSNP
rs1035437925 3382 dbSNP
rs1242677466 3386 dbSNP
rs1205927917 3408 dbSNP
rs569681977 3417 dbSNP
rs1486724259 3419 dbSNP
rs1249311262 3423 dbSNP
rs1226204000 3424 dbSNP
rs1307645270 3425 dbSNP
rs1197089351 3435 dbSNP
rs755904182 3441 dbSNP
rs1381869338 3443 dbSNP
rs532935764 3446 dbSNP
rs1480534801 3448 dbSNP
rs767541086 3455 dbSNP
rs1409096193 3465 dbSNP
rs1010043366 3467 dbSNP
rs1394044785 3476 dbSNP
rs551369442 3480 dbSNP
rs1297861322 3481 dbSNP
rs1462685093 3482 dbSNP
rs564818396 3496 dbSNP
rs1319551125 3497 dbSNP
rs905110200 3500 dbSNP
rs1444594645 3506 dbSNP
rs1386349261 3509 dbSNP
rs11933219 3513 dbSNP
rs1436469900 3514 dbSNP
rs1034869479 3525 dbSNP
rs1194927451 3530 dbSNP
rs1483143694 3532 dbSNP
rs1276166219 3540 dbSNP
rs1346575329 3548 dbSNP
rs113373659 3555 dbSNP
rs1246863687 3557 dbSNP
rs1333835123 3559 dbSNP
rs1286746561 3566 dbSNP
rs911175783 3568 dbSNP
rs1392195863 3569 dbSNP
rs1350010150 3574 dbSNP
rs568557170 3575 dbSNP
rs1301396621 3586 dbSNP
rs1224472839 3588 dbSNP
rs1424149775 3594 dbSNP
rs1366236818 3605 dbSNP
rs1284857868 3611 dbSNP
rs1165574940 3612 dbSNP
rs1469039041 3615 dbSNP
rs964009829 3616 dbSNP
rs1363594343 3618 dbSNP
rs1182891420 3628 dbSNP
rs1318597210 3635 dbSNP
rs976744014 3643 dbSNP
rs982572165 3644 dbSNP
rs1267850840 3662 dbSNP
rs6820224 3669 dbSNP
rs1289967676 3671 dbSNP
rs113888694 3672 dbSNP
rs1348383659 3673 dbSNP
rs1278744907 3685 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions TZM-bl
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM1462574. RNA binding protein: AGO2. Condition:TZM-bl ami BaL ...

- Whisnant AW; Bogerd HP; Flores O; Ho P; et al., 2013, mBio.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' cgGGAGGGGACUGAGGGACu 5'
            :| ||::|  ||||||| 
Target 5' --UCCCCUUUUCCUCCCUG- 3'
 		1 - 17
Article - Whisnant AW; Bogerd HP; Flores O; Ho P; et al.
- mBio, 2013
UNLABELLED: The question of how HIV-1 interfaces with cellular microRNA (miRNA) biogenesis and effector mechanisms has been highly controversial. Here, we first used deep sequencing of small RNAs present in two different infected cell lines (TZM-bl and C8166) and two types of primary human cells (CD4(+) peripheral blood mononuclear cells [PBMCs] and macrophages) to unequivocally demonstrate that HIV-1 does not encode any viral miRNAs. Perhaps surprisingly, we also observed that infection of T cells by HIV-1 has only a modest effect on the expression of cellular miRNAs at early times after infection. Comprehensive analysis of miRNA binding to the HIV-1 genome using the photoactivatable ribonucleoside-induced cross-linking and immunoprecipitation (PAR-CLIP) technique revealed several binding sites for cellular miRNAs, a subset of which were shown to be capable of mediating miRNA-mediated repression of gene expression. However, the main finding from this analysis is that HIV-1 transcripts are largely refractory to miRNA binding, most probably due to extensive viral RNA secondary structure. Together, these data demonstrate that HIV-1 neither encodes viral miRNAs nor strongly influences cellular miRNA expression, at least early after infection, and imply that HIV-1 transcripts have evolved to avoid inhibition by preexisting cellular miRNAs by adopting extensive RNA secondary structures that occlude most potential miRNA binding sites. IMPORTANCE: MicroRNAs (miRNAs) are a ubiquitous class of small regulatory RNAs that serve as posttranscriptional regulators of gene expression. Previous work has suggested that HIV-1 might subvert the function of the cellular miRNA machinery by expressing viral miRNAs or by dramatically altering the level of cellular miRNA expression. Using very sensitive approaches, we now demonstrate that neither of these ideas is in fact correct. Moreover, HIV-1 transcripts appear to largely avoid regulation by cellular miRNAs by adopting an extensive RNA secondary structure that occludes the ability of cellular miRNAs to interact with viral mRNAs. Together, these data suggest that HIV-1, rather than seeking to control miRNA function in infected cells, has instead evolved a mechanism to become largely invisible to cellular miRNA effector mechanisms.
LinkOut: [PMID: 23592263]
CLIP-seq Support 1 for dataset GSM1462574
Method / RBP PAR-CLIP / AGO2
Cell line / Condition TZM-bl / TZM-bl ami BaL
Location of target site ENST00000456874.2 | 3UTR | UCCCCUUUUCCUCCCUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23592263 / GSE59944
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
146 hsa-miR-4270 Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT056076 PIP4K2A phosphatidylinositol-5-phosphate 4-kinase type 2 alpha 2 2
MIRT057833 SLC30A7 solute carrier family 30 member 7 2 2
MIRT109295 TXLNG taxilin gamma 2 2
MIRT117521 MIDN midnolin 2 2
MIRT183504 BTG2 BTG anti-proliferation factor 2 2 2
MIRT258346 HOXA11 homeobox A11 2 6
MIRT275743 TFDP1 transcription factor Dp-1 2 2
MIRT284426 CAPN15 calpain 15 2 2
MIRT386430 CCL22 C-C motif chemokine ligand 22 2 2
MIRT443374 PLXNA2 plexin A2 2 2
MIRT445251 SEMA5A semaphorin 5A 2 2
MIRT445767 CCND3 cyclin D3 2 2
MIRT447231 ABI2 abl interactor 2 2 2
MIRT451224 ZNF444 zinc finger protein 444 2 2
MIRT451433 TJP3 tight junction protein 3 2 4
MIRT451959 TMPRSS5 transmembrane protease, serine 5 2 2
MIRT452006 FKBP5 FK506 binding protein 5 2 2
MIRT452300 EIF5AL1 eukaryotic translation initiation factor 5A-like 1 2 2
MIRT452717 DTHD1 death domain containing 1 2 2
MIRT453361 ZNF3 zinc finger protein 3 2 2
MIRT453458 GLG1 golgi glycoprotein 1 2 2
MIRT453832 SAA1 serum amyloid A1 2 2
MIRT453928 COMMD5 COMM domain containing 5 2 4
MIRT454312 ZNF134 zinc finger protein 134 2 2
MIRT454493 SLC29A1 solute carrier family 29 member 1 (Augustine blood group) 2 2
MIRT454836 POLR2J3 RNA polymerase II subunit J3 2 2
MIRT455142 TBC1D25 TBC1 domain family member 25 2 2
MIRT455922 RAPGEF1 Rap guanine nucleotide exchange factor 1 2 2
MIRT456163 TTF2 transcription termination factor 2 2 2
MIRT456395 KLHL12 kelch like family member 12 2 2
MIRT456786 MTHFSD methenyltetrahydrofolate synthetase domain containing 2 2
MIRT457164 MXRA7 matrix remodeling associated 7 2 2
MIRT457190 ERC1 ELKS/RAB6-interacting/CAST family member 1 2 2
MIRT457415 RPL36 ribosomal protein L36 2 2
MIRT457630 UPK3BL uroplakin 3B like 1 2 2
MIRT458720 VPS39 VPS39, HOPS complex subunit 2 2
MIRT458745 CES2 carboxylesterase 2 2 2
MIRT459269 ADRBK1 G protein-coupled receptor kinase 2 2 2
MIRT459490 CCL11 C-C motif chemokine ligand 11 2 2
MIRT460319 SH3RF1 SH3 domain containing ring finger 1 2 2
MIRT461005 SYT7 synaptotagmin 7 2 2
MIRT461579 SCO1 SCO1, cytochrome c oxidase assembly protein 2 4
MIRT461820 SNAP23 synaptosome associated protein 23 2 2
MIRT463332 ZFHX3 zinc finger homeobox 3 2 2
MIRT463449 ZC3HAV1L zinc finger CCCH-type containing, antiviral 1 like 2 2
MIRT464272 VCL vinculin 2 2
MIRT464895 UBALD1 UBA like domain containing 1 2 2
MIRT465556 TOB2 transducer of ERBB2, 2 2 2
MIRT466360 THBS1 thrombospondin 1 2 2
MIRT466956 STAT3 signal transducer and activator of transcription 3 2 2
MIRT467321 SPATA2 spermatogenesis associated 2 2 2
MIRT467440 SND1 staphylococcal nuclease and tudor domain containing 1 2 2
MIRT467823 SLC29A2 solute carrier family 29 member 2 2 2
MIRT471173 PHB2 prohibitin 2 2 2
MIRT471397 PDPR pyruvate dehydrogenase phosphatase regulatory subunit 2 2
MIRT471754 OGT O-linked N-acetylglucosamine (GlcNAc) transferase 2 2
MIRT471846 NUFIP2 NUFIP2, FMR1 interacting protein 2 2 2
MIRT472020 NPTXR neuronal pentraxin receptor 2 2
MIRT472224 NGFR nerve growth factor receptor 2 2
MIRT472439 NBL1 neuroblastoma 1, DAN family BMP antagonist 2 2
MIRT472541 NACC1 nucleus accumbens associated 1 2 2
MIRT473195 MINOS1-NBL1 MINOS1-NBL1 readthrough 2 2
MIRT473211 MINK1 misshapen like kinase 1 2 2
MIRT473668 MARCKSL1 MARCKS like 1 2 2
MIRT474852 KHSRP KH-type splicing regulatory protein 2 2
MIRT474939 KCTD15 potassium channel tetramerization domain containing 15 2 2
MIRT477330 EPHA2 EPH receptor A2 2 2
MIRT477395 ENTPD7 ectonucleoside triphosphate diphosphohydrolase 7 2 2
MIRT477466 ELMSAN1 ELM2 and Myb/SANT domain containing 1 2 2
MIRT477974 DPM2 dolichyl-phosphate mannosyltransferase subunit 2, regulatory 2 2
MIRT478331 DDN dendrin 2 2
MIRT479481 CDK2 cyclin dependent kinase 2 2 2
MIRT481212 ATXN7L3B ataxin 7 like 3B 2 2
MIRT481263 ATXN7L3 ataxin 7 like 3 2 2
MIRT481409 ASXL1 additional sex combs like 1, transcriptional regulator 2 2
MIRT482051 AMD1 adenosylmethionine decarboxylase 1 2 2
MIRT482396 AEN apoptosis enhancing nuclease 2 2
MIRT483160 PCSK2 proprotein convertase subtilisin/kexin type 2 2 7
MIRT483370 CYP4A22 cytochrome P450 family 4 subfamily A member 22 2 2
MIRT483520 QRSL1 glutaminyl-tRNA synthase (glutamine-hydrolyzing)-like 1 2 4
MIRT484059 CYP4A11 cytochrome P450 family 4 subfamily A member 11 2 2
MIRT487075 CLASP1 cytoplasmic linker associated protein 1 2 4
MIRT487421 CACNB1 calcium voltage-gated channel auxiliary subunit beta 1 2 2
MIRT488359 PAX2 paired box 2 2 2
MIRT488592 ST7L suppression of tumorigenicity 7 like 2 2
MIRT489556 SOX11 SRY-box 11 2 4
MIRT489804 KRT80 keratin 80 2 4
MIRT489865 ATP2A3 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3 2 2
MIRT490014 KIFC2 kinesin family member C2 2 2
MIRT490036 PCSK4 proprotein convertase subtilisin/kexin type 4 2 2
MIRT491070 ACVR1B activin A receptor type 1B 2 2
MIRT494016 DUSP9 dual specificity phosphatase 9 2 2
MIRT494816 AKAP11 A-kinase anchoring protein 11 2 2
MIRT495991 LTBP2 latent transforming growth factor beta binding protein 2 2 2
MIRT496272 SLC2A13 solute carrier family 2 member 13 2 2
MIRT500454 ZFP36L1 ZFP36 ring finger protein like 1 2 2
MIRT507989 BCL2L13 BCL2 like 13 2 4
MIRT509713 ANKRD23 ankyrin repeat domain 23 2 2
MIRT527984 TSLP thymic stromal lymphopoietin 2 2
MIRT530448 SULT1B1 sulfotransferase family 1B member 1 2 2
MIRT531235 FANCC Fanconi anemia complementation group C 2 2
MIRT534590 RPL28 ribosomal protein L28 2 2
MIRT535990 MED28 mediator complex subunit 28 2 4
MIRT537280 GABRA5 gamma-aminobutyric acid type A receptor alpha5 subunit 2 2
MIRT539924 DUSP28 dual specificity phosphatase 28 2 2
MIRT554711 RNF146 ring finger protein 146 2 2
MIRT558962 CAMSAP2 calmodulin regulated spectrin associated protein family member 2 2 2
MIRT568497 ARHGDIA Rho GDP dissociation inhibitor alpha 2 2
MIRT568875 LY6H lymphocyte antigen 6 family member H 2 2
MIRT568987 CACNA1C calcium voltage-gated channel subunit alpha1 C 2 2
MIRT569990 TMEM184A transmembrane protein 184A 2 2
MIRT570485 THRA thyroid hormone receptor, alpha 2 2
MIRT572826 MYO1C myosin IC 2 2
MIRT608199 ERBB2 erb-b2 receptor tyrosine kinase 2 2 2
MIRT613220 CCDC85C coiled-coil domain containing 85C 2 4
MIRT629782 PTDSS2 phosphatidylserine synthase 2 2 2
MIRT635332 RASSF4 Ras association domain family member 4 2 2
MIRT653632 SLC30A3 solute carrier family 30 member 3 2 2
MIRT664572 GUF1 GUF1 homolog, GTPase 2 2
MIRT667855 IPCEF1 interaction protein for cytohesin exchange factors 1 2 2
MIRT668820 CYLD CYLD lysine 63 deubiquitinase 2 2
MIRT671274 ETFDH electron transfer flavoprotein dehydrogenase 2 2
MIRT681448 CIITA class II major histocompatibility complex transactivator 2 2
MIRT684817 BRIX1 BRX1, biogenesis of ribosomes 2 2
MIRT685861 ANGEL1 angel homolog 1 2 2
MIRT688812 CAPZB capping actin protein of muscle Z-line beta subunit 2 2
MIRT691198 NIF3L1 NGG1 interacting factor 3 like 1 2 2
MIRT696947 CERK ceramide kinase 2 2
MIRT699741 SERBP1 SERPINE1 mRNA binding protein 1 2 2
MIRT701259 NUP35 nucleoporin 35 2 2
MIRT701935 MLLT1 MLLT1, super elongation complex subunit 2 2
MIRT703332 GDPD5 glycerophosphodiester phosphodiesterase domain containing 5 2 2
MIRT705519 ARL6IP1 ADP ribosylation factor like GTPase 6 interacting protein 1 2 2
MIRT706065 PKD1 polycystin 1, transient receptor potential channel interacting 2 2
MIRT713238 SV2B synaptic vesicle glycoprotein 2B 2 2
MIRT714670 CHRNE cholinergic receptor nicotinic epsilon subunit 2 2
MIRT715001 TSPAN11 tetraspanin 11 2 2
MIRT715356 VCAM1 vascular cell adhesion molecule 1 2 2
MIRT715971 FADS3 fatty acid desaturase 3 2 2
MIRT719585 FNBP4 formin binding protein 4 2 2
MIRT719667 DMRT2 doublesex and mab-3 related transcription factor 2 2 2
MIRT723360 ASCL2 achaete-scute family bHLH transcription factor 2 2 2
MIRT734985 GADD45A growth arrest and DNA damage inducible alpha 2 0
MIRT735022 MMP19 matrix metallopeptidase 19 3 0
MIRT737359 SATB2 SATB homeobox 2 3 0
MIRT756223 MCM3 minichromosome maintenance complex component 3 3 1
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-4 Dexamethasone approved 5743 Microarray primary rat thymocytes 20847043 2010 up-regulated
miR-4270 Ginsenoside Rh2 NULL 119307 Microarray NSCLC cell line A549 23152132 2013 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-4270 Platinum 23939 sensitive High Ovarian Cancer tissue
hsa-miR-4270 Fulvestrant 17756771 NSC719276 approved sensitive High Breast Cancer cell line (MCF-7)
hsa-miR-4270 Cisplatin 5460033 NSC119875 approved resistant High Hypopharyngeal Cancer cell line (FaDu)
hsa-mir-4270 Cisplatin 5460033 NSC119875 approved resistant cell line (BxPC3)
hsa-miR-4270 Cisplatin 5460033 NSC119875 approved resistant cell line (CAL-27) (cytosolic RNA)
hsa-miR-4270 Cisplatin 5460033 NSC119875 approved sensitive cell line (CAL-27) (total RNA)
hsa-miR-4270 Cisplatin 5460033 NSC119875 approved resistant cell line (CP20)
hsa-miR-4270 Cisplatin 5460033 NSC119875 approved resistant cell line (CIS)
hsa-miR-4270 Osimertinib 71496458 NSC779217 approved resistant cell line (H1975)
hsa-miR-4270 Gemcitabine 60750 NSC613327 approved resistant cell line (MDA-231)
hsa-miR-4270 Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-4270 Vemurafenib 42611257 NSC761431 approved sensitive cell line (LM16)
hsa-miR-4270 Gemcitabine 60750 NSC613327 approved sensitive cell line (PANC-1) (1500 ng/ml)
hsa-miR-4270 Gemcitabine 60750 NSC613327 approved sensitive cell line (PANC-1) (100 ng/ml)
hsa-miR-4270 Gemcitabine 60750 NSC613327 approved resistant cell line (Panc1-GR4)

Error report submission