miRTarBase - #MIRT452788


—
pre-miRNA Information
pre-miRNA hsa-mir-4651   
Genomic Coordinates chr7: 75915197 - 75915269
Description Homo sapiens miR-4651 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-4651
Sequence 10| CGGGGUGGGUGAGGUCGGGC |29
Evidence Experimental
Experiments Illumina
DRVs in miRNA
Mutant ID Mutant Position Mutant Source
COSN30595227 5 COSMIC
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1458858872 1 dbSNP
rs887877274 2 dbSNP
rs559953168 4 dbSNP
rs1332072774 12 dbSNP
rs868980356 12 dbSNP
rs1291879524 14 dbSNP
rs1228835859 19 dbSNP
rs1349605668 19 dbSNP
rs1277626081 20 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol FAM136A   
Synonyms -
Description family with sequence similarity 136 member A
Transcript NM_032822   
Expression
Putative miRNA Targets on FAM136A
3'UTR of FAM136A
(miRNA target sites are highlighted)		 
>FAM136A|NM_032822|3'UTR
   1 AAGTATTTGCCAGTGGCCATCAGGGCTGAGGGCAAGAATATATTTTTTATAAGGAATTGGGAATTTTAGTCTTTTAAGCA
  81 AAGTTTACGAATGAAGAAATGAAGGATGGCCACAAGCGTAAGGCATATGTCACTTGCCTCTGGACACTGGTTATTTTATG
 161 TTTCAGTCCCTAAAAAATGAAATGGAAAAAAGTGGTGCTAAATCGAGTCAGAGATATTACAGGAGAGTTTTAGAGCTTAT
 241 TATTTCCTGTGGCCAGTGCTTGTCCTGGCAGTAAGGCTTTCCCCTGTAACAAGCCAGAGCCCTCCAAGGTACCAGACTCT
 321 TCTTACTACACAGGTACTAACAGGCTGGCAGGTTAGAGTTGGTGGAGTCTGAGGAGAGATATTTTCTCTTTGTTGCCAAC
 401 ATCCTGTTTACCAAAAGTGTCACCCCACCATCTTCCATAAGCTGTGAAACAAAATCAATGAGGTCACTAACTTAGAAGGG
 481 AAAGAAAGTTTTCTGGGTCTTTGTTTTCTTGATTTGGGGTAATTTATACAAGGGCATACAAGTTGATTTTAAGATGTGGA
 561 ACTGGGAGGTAGACTAGTTTGGATAAGAACTTTGAAATGTTCCTTGTGGATCCCCATTTCTGGTCATCAAGATGTGGATG
 641 TACATTTCTTAAAATTATTACATGCTGCATCTTTCAGCCTGGAGACTGTGCAGAAACATGAGAGGTGATGACACACTAAT
 721 TATGGGAAGCAGAATTACTGGCTGATGGCCCCTGAGGCTGTGTGTAACAAAATGACAGGACAATCTTGCAGTAACACTTT
 801 CCCCTTGAAGAGAAGGGGGTTTTGATTGTGATATATACTAGTATCTAGGAATGAACAGTAAAAGAGGAGCAGTTGGCTAC
 881 TTGATTACAACAGAGTAAATGAAGTACTGGATTTGGGAAAACCTGGTTTTATTAGAACATATGGAATGAAAGCCTACACC
 961 TAGCATTGCCTACTTAGCCCCCTGAATTAACAGAGCCCAATTGAGACAAACCCCTGGCAACAGGAAATTCAAGGGAGAAA
1041 AAGTAAGCAACTTGGGCTAGGATGAGCTGACTCCCTTAGAGCAAAGGAGAGACAGCCCCCATTACCAAATACCATTTTTG
1121 CCTGGGGCTTGTGCAGCTGGCAGTGTTCCTGCCCCAGCATGGCACCTTATTGTTTTGATAGCAACTTCGTTGAATTTTCA
1201 CCAACTTATTACTTGAAATTATAATATAGCCTGTCCGTTTGCTGTTTCCAGGCTGTGATATATTTTCCTAGTGGTTTGAC
1281 TTTAAAAATAAATAAGGTTTAATTTTCTCCCCAAAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' cgggcuggagugGGUGGGGc 5'
                      :|||||| 
Target 5' ttaccaaaagtgTCACCCCa 3'
 408 - 427 124.00 -12.69
2 
miRNA  3' cgGGCUG--GAGUGGGUGGGGc 5'
            |:|:|  : : ||::|||| 
Target 5' agCTGGCAGTGTTCCTGCCCCa 3'
 1135 - 1156 116.00 -17.80
3 
miRNA  3' cgggCUGGAGUGGGUGGGGc 5'
              ||:|   ||||:::| 
Target 5' tgtgGATC---CCCATTTCt 3'
 605 - 621 101.00 -11.90
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN31524795 71 COSMIC
COSN31511360 82 COSMIC
COSN20066754 83 COSMIC
COSN19728249 109 COSMIC
COSN6420882 115 COSMIC
COSN6420881 117 COSMIC
COSN19662044 129 COSMIC
COSN17440799 168 COSMIC
COSN17439454 179 COSMIC
COSN31540174 216 COSMIC
COSN17442103 259 COSMIC
COSN26556735 259 COSMIC
COSN25611984 262 COSMIC
COSN26585174 269 COSMIC
COSN25082307 277 COSMIC
COSN24872903 337 COSMIC
COSN24873521 338 COSMIC
COSN23040742 342 COSMIC
COSN24872890 369 COSMIC
COSN32055602 716 COSMIC
COSN24359265 997 COSMIC
COSN22407560 1002 COSMIC
COSN15131738 1021 COSMIC
COSN24367861 1048 COSMIC
COSN24360243 1051 COSMIC
COSN6420880 1061 COSMIC
COSN28815034 1089 COSMIC
COSN29676192 1092 COSMIC
COSN23218518 1115 COSMIC
COSN31546535 1206 COSMIC
rs14234 279 GWAS
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1439619827 4 dbSNP
rs77938271 5 dbSNP
rs1303290201 7 dbSNP
rs762845188 8 dbSNP
rs1257706541 9 dbSNP
rs1363085016 12 dbSNP
rs753999154 15 dbSNP
rs766678093 19 dbSNP
rs760686518 24 dbSNP
rs77117086 25 dbSNP
rs1186472921 29 dbSNP
rs772523237 31 dbSNP
rs1271304065 40 dbSNP
rs1200334990 43 dbSNP
rs762289428 48 dbSNP
rs775888791 49 dbSNP
rs79420153 52 dbSNP
rs74887001 53 dbSNP
rs1435055739 57 dbSNP
rs943302402 62 dbSNP
rs1229532322 68 dbSNP
rs1297386585 69 dbSNP
rs76094877 70 dbSNP
rs1403084303 75 dbSNP
rs1412706463 79 dbSNP
rs1483257685 83 dbSNP
rs75462642 88 dbSNP
rs13412696 89 dbSNP
rs1465994487 96 dbSNP
rs1188947841 99 dbSNP
rs74403173 101 dbSNP
rs1447565314 103 dbSNP
rs1178066386 112 dbSNP
rs1187651234 114 dbSNP
rs76030446 115 dbSNP
rs75344193 117 dbSNP
rs116073039 118 dbSNP
rs1449930027 122 dbSNP
rs1289499485 125 dbSNP
rs1320300185 127 dbSNP
rs1229127441 128 dbSNP
rs145714883 135 dbSNP
rs562280849 137 dbSNP
rs146456935 140 dbSNP
rs1302507335 148 dbSNP
rs80198161 153 dbSNP
rs1295869335 159 dbSNP
rs1231831080 162 dbSNP
rs1228053873 168 dbSNP
rs1366636183 169 dbSNP
rs1323135245 171 dbSNP
rs77046976 177 dbSNP
rs1484730084 178 dbSNP
rs1348770287 179 dbSNP
rs1323589039 185 dbSNP
rs1013464750 186 dbSNP
rs1406767869 189 dbSNP
rs1414366605 191 dbSNP
rs1457954060 192 dbSNP
rs1387863018 194 dbSNP
rs1386735071 197 dbSNP
rs1439006945 199 dbSNP
rs1167737973 204 dbSNP
rs895027150 205 dbSNP
rs1449828870 206 dbSNP
rs1392016261 207 dbSNP
rs1189362866 213 dbSNP
rs112292798 215 dbSNP
rs1314784721 217 dbSNP
rs1223466318 227 dbSNP
rs1265851637 229 dbSNP
rs1488114276 232 dbSNP
rs200270929 235 dbSNP
rs1222315968 242 dbSNP
rs1181592084 250 dbSNP
rs1409969828 250 dbSNP
rs899153189 251 dbSNP
rs1165894036 256 dbSNP
rs796199640 259 dbSNP
rs796577563 262 dbSNP
rs1310316087 264 dbSNP
rs546469589 266 dbSNP
rs1343283712 272 dbSNP
rs1300510613 275 dbSNP
rs796524210 277 dbSNP
rs14234 279 dbSNP
rs370771992 282 dbSNP
rs557691122 284 dbSNP
rs1368377008 286 dbSNP
rs113004836 301 dbSNP
rs1276641169 304 dbSNP
rs1430207136 307 dbSNP
rs1483355738 313 dbSNP
rs540780461 318 dbSNP
rs1173654281 323 dbSNP
rs1204499873 325 dbSNP
rs1413845964 334 dbSNP
rs768939966 336 dbSNP
rs796615893 337 dbSNP
rs796457334 338 dbSNP
rs1443117497 341 dbSNP
rs796994286 342 dbSNP
rs184732776 343 dbSNP
rs1306866785 344 dbSNP
rs1483476292 349 dbSNP
rs1051896980 351 dbSNP
rs1449602902 352 dbSNP
rs1172770945 356 dbSNP
rs878995414 362 dbSNP
rs1284355839 363 dbSNP
rs1378032115 368 dbSNP
rs796668548 369 dbSNP
rs749505272 374 dbSNP
rs780324218 380 dbSNP
rs1227665396 386 dbSNP
rs147859234 390 dbSNP
rs1312135682 399 dbSNP
rs756242471 403 dbSNP
rs1444149534 405 dbSNP
rs1279932953 406 dbSNP
rs1220517682 410 dbSNP
rs1237067460 411 dbSNP
rs1348049686 414 dbSNP
rs1190870997 418 dbSNP
rs957970362 420 dbSNP
rs1287379681 425 dbSNP
rs1410091928 426 dbSNP
rs1351882509 432 dbSNP
rs1415645525 446 dbSNP
rs1058256 449 dbSNP
rs1404875595 456 dbSNP
rs1450064730 457 dbSNP
rs978259052 458 dbSNP
rs1365737738 459 dbSNP
rs781698209 463 dbSNP
rs1434115473 472 dbSNP
rs867940521 484 dbSNP
rs966399250 487 dbSNP
rs1465350434 489 dbSNP
rs1359740764 509 dbSNP
rs1178106809 511 dbSNP
rs1471025130 512 dbSNP
rs1409879798 516 dbSNP
rs1158468705 518 dbSNP
rs1473043587 521 dbSNP
rs1252854213 526 dbSNP
rs1180534954 528 dbSNP
rs1278052111 529 dbSNP
rs1321664596 531 dbSNP
rs1210882457 534 dbSNP
rs1248894699 538 dbSNP
rs1483124693 543 dbSNP
rs1024766405 552 dbSNP
rs1248914730 556 dbSNP
rs144479933 558 dbSNP
rs556231531 562 dbSNP
rs1327654763 570 dbSNP
rs959194062 590 dbSNP
rs796085063 593 dbSNP
rs1388931417 597 dbSNP
rs374095424 598 dbSNP
rs369622751 599 dbSNP
rs1332723604 602 dbSNP
rs145815815 604 dbSNP
rs2169836 605 dbSNP
rs757617687 612 dbSNP
rs1379597118 615 dbSNP
rs1343653362 621 dbSNP
rs199779428 622 dbSNP
rs539672594 633 dbSNP
rs1328777250 640 dbSNP
rs1203733522 650 dbSNP
rs570484756 659 dbSNP
rs995420001 661 dbSNP
rs1452689782 662 dbSNP
rs899178399 669 dbSNP
rs1319985467 671 dbSNP
rs1457822490 675 dbSNP
rs1037677338 684 dbSNP
rs1412219282 686 dbSNP
rs1365829810 687 dbSNP
rs1156587630 688 dbSNP
rs1334191582 688 dbSNP
rs1162905774 689 dbSNP
rs1423641724 691 dbSNP
rs1415002118 693 dbSNP
rs1185744564 697 dbSNP
rs1302395386 698 dbSNP
rs143112049 708 dbSNP
rs570765816 708 dbSNP
rs200745741 716 dbSNP
rs547734639 718 dbSNP
rs1289120886 720 dbSNP
rs1208884747 723 dbSNP
rs1237242024 730 dbSNP
rs751893782 732 dbSNP
rs1357429440 737 dbSNP
rs1209625246 742 dbSNP
rs534308525 744 dbSNP
rs1486544574 749 dbSNP
rs1263364767 752 dbSNP
rs1243640216 753 dbSNP
rs1251986989 756 dbSNP
rs1321907987 767 dbSNP
rs1316897524 776 dbSNP
rs1179152071 777 dbSNP
rs1225829272 785 dbSNP
rs1364442407 795 dbSNP
rs1472980690 798 dbSNP
rs1162719687 803 dbSNP
rs1383280173 808 dbSNP
rs1321134958 811 dbSNP
rs1431595310 817 dbSNP
rs201562661 824 dbSNP
rs764431346 834 dbSNP
rs1387198756 837 dbSNP
rs1389761788 840 dbSNP
rs1336331510 844 dbSNP
rs1004976540 852 dbSNP
rs1245644760 870 dbSNP
rs1457601532 873 dbSNP
rs1313422682 876 dbSNP
rs1344921315 879 dbSNP
rs1350632189 888 dbSNP
rs1251250027 895 dbSNP
rs1165929754 897 dbSNP
rs1448044716 900 dbSNP
rs1257785611 905 dbSNP
rs1442683474 907 dbSNP
rs1182727654 908 dbSNP
rs1390146845 909 dbSNP
rs1189753026 911 dbSNP
rs1430763340 917 dbSNP
rs1264692877 922 dbSNP
rs1460483141 922 dbSNP
rs1208658237 931 dbSNP
rs1488611075 932 dbSNP
rs1293471687 934 dbSNP
rs1335138793 939 dbSNP
rs1202842177 940 dbSNP
rs1436297229 941 dbSNP
rs192998668 942 dbSNP
rs796087556 948 dbSNP
rs1298299911 952 dbSNP
rs796132548 957 dbSNP
rs796985442 959 dbSNP
rs1323786928 966 dbSNP
rs1299304774 969 dbSNP
rs886482059 972 dbSNP
rs1188994940 978 dbSNP
rs201335807 980 dbSNP
rs796702136 981 dbSNP
rs762662338 983 dbSNP
rs1201079962 985 dbSNP
rs1378350889 993 dbSNP
rs1051846363 995 dbSNP
rs1428277112 996 dbSNP
rs372109144 997 dbSNP
rs548683130 1001 dbSNP
rs1288697526 1007 dbSNP
rs1463984106 1011 dbSNP
rs1302757856 1017 dbSNP
rs3860 1021 dbSNP
rs1222385442 1022 dbSNP
rs1260808600 1027 dbSNP
rs1197615930 1033 dbSNP
rs1433260825 1047 dbSNP
rs112339794 1048 dbSNP
rs186742332 1050 dbSNP
rs76630026 1051 dbSNP
rs79780439 1061 dbSNP
rs1480124126 1065 dbSNP
rs182407545 1071 dbSNP
rs1473069735 1078 dbSNP
rs1158817684 1079 dbSNP
rs1343869826 1086 dbSNP
rs1197277414 1092 dbSNP
rs1294571425 1093 dbSNP
rs1365529505 1093 dbSNP
rs1342860996 1094 dbSNP
rs904231646 1099 dbSNP
rs1042934365 1100 dbSNP
rs1346207355 1114 dbSNP
rs1285218813 1120 dbSNP
rs1408270276 1131 dbSNP
rs1350033644 1132 dbSNP
rs1329984427 1133 dbSNP
rs1393487046 1136 dbSNP
rs1400779101 1139 dbSNP
rs1172473647 1143 dbSNP
rs1466144541 1148 dbSNP
rs1430812483 1155 dbSNP
rs1156263689 1156 dbSNP
rs1472061054 1158 dbSNP
rs752314536 1164 dbSNP
rs1183809207 1165 dbSNP
rs550502433 1180 dbSNP
rs1385120256 1182 dbSNP
rs1440454753 1186 dbSNP
rs141562939 1188 dbSNP
rs764774297 1189 dbSNP
rs1325542063 1193 dbSNP
rs1371800295 1196 dbSNP
rs1265085731 1197 dbSNP
rs1297200581 1199 dbSNP
rs1370771045 1200 dbSNP
rs1226590143 1201 dbSNP
rs1328814414 1204 dbSNP
rs922110418 1207 dbSNP
rs1276693165 1213 dbSNP
rs1438409987 1216 dbSNP
rs1280352684 1220 dbSNP
rs1241675881 1221 dbSNP
rs1339054285 1223 dbSNP
rs1333862433 1225 dbSNP
rs532801342 1227 dbSNP
rs1454010514 1233 dbSNP
rs530731838 1236 dbSNP
rs1318026636 1237 dbSNP
rs1456247524 1239 dbSNP
rs1408321707 1241 dbSNP
rs1159919552 1245 dbSNP
rs1471578090 1248 dbSNP
rs192434309 1257 dbSNP
rs1187916196 1258 dbSNP
rs1242978413 1265 dbSNP
rs1443175883 1271 dbSNP
rs936910731 1276 dbSNP
rs1462610189 1279 dbSNP
rs7459 1280 dbSNP
rs879039981 1280 dbSNP
rs1169186581 1289 dbSNP
rs1449853961 1294 dbSNP
rs1337142649 1296 dbSNP
rs924949214 1305 dbSNP
rs187960296 1307 dbSNP
rs966347155 1313 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions TZM-bl
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM1462574. RNA binding protein: AGO2. Condition:TZM-bl ami BaL ...

- Whisnant AW; Bogerd HP; Flores O; Ho P; et al., 2013, mBio.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' cgggcuggagugGGUGGGGc 5'
                      :|||||| 
Target 5' ------------UCACCCCa 3'
 		1 - 8
Article - Whisnant AW; Bogerd HP; Flores O; Ho P; et al.
- mBio, 2013
UNLABELLED: The question of how HIV-1 interfaces with cellular microRNA (miRNA) biogenesis and effector mechanisms has been highly controversial. Here, we first used deep sequencing of small RNAs present in two different infected cell lines (TZM-bl and C8166) and two types of primary human cells (CD4(+) peripheral blood mononuclear cells [PBMCs] and macrophages) to unequivocally demonstrate that HIV-1 does not encode any viral miRNAs. Perhaps surprisingly, we also observed that infection of T cells by HIV-1 has only a modest effect on the expression of cellular miRNAs at early times after infection. Comprehensive analysis of miRNA binding to the HIV-1 genome using the photoactivatable ribonucleoside-induced cross-linking and immunoprecipitation (PAR-CLIP) technique revealed several binding sites for cellular miRNAs, a subset of which were shown to be capable of mediating miRNA-mediated repression of gene expression. However, the main finding from this analysis is that HIV-1 transcripts are largely refractory to miRNA binding, most probably due to extensive viral RNA secondary structure. Together, these data demonstrate that HIV-1 neither encodes viral miRNAs nor strongly influences cellular miRNA expression, at least early after infection, and imply that HIV-1 transcripts have evolved to avoid inhibition by preexisting cellular miRNAs by adopting extensive RNA secondary structures that occlude most potential miRNA binding sites. IMPORTANCE: MicroRNAs (miRNAs) are a ubiquitous class of small regulatory RNAs that serve as posttranscriptional regulators of gene expression. Previous work has suggested that HIV-1 might subvert the function of the cellular miRNA machinery by expressing viral miRNAs or by dramatically altering the level of cellular miRNA expression. Using very sensitive approaches, we now demonstrate that neither of these ideas is in fact correct. Moreover, HIV-1 transcripts appear to largely avoid regulation by cellular miRNAs by adopting an extensive RNA secondary structure that occludes the ability of cellular miRNAs to interact with viral mRNAs. Together, these data suggest that HIV-1, rather than seeking to control miRNA function in infected cells, has instead evolved a mechanism to become largely invisible to cellular miRNA effector mechanisms.
LinkOut: [PMID: 23592263]
CLIP-seq Support 1 for dataset GSM1462574
Method / RBP PAR-CLIP / AGO2
Cell line / Condition TZM-bl / TZM-bl ami BaL
Location of target site ENST00000450256.1 | 3UTR | UCACCCCACCAUCUUCCAUAAGCUGUGAAACAAAAUCAAUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23592263 / GSE59944
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
121 hsa-miR-4651 Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT066212 MARCH9 membrane associated ring-CH-type finger 9 2 2
MIRT113270 TMBIM6 transmembrane BAX inhibitor motif containing 6 2 2
MIRT115795 CAPN15 calpain 15 2 2
MIRT125296 MID1IP1 MID1 interacting protein 1 2 2
MIRT145419 ANKRD13B ankyrin repeat domain 13B 2 2
MIRT153779 NCOA3 nuclear receptor coactivator 3 2 2
MIRT189384 TXLNA taxilin alpha 2 4
MIRT451063 PNMAL2 paraneoplastic Ma antigen family member 8B 2 2
MIRT451142 C19orf53 chromosome 19 open reading frame 53 2 2
MIRT452374 LY6E lymphocyte antigen 6 family member E 2 4
MIRT452788 FAM136A family with sequence similarity 136 member A 2 2
MIRT452985 CABP4 calcium binding protein 4 2 2
MIRT453231 FTSJ3 FtsJ RNA methyltransferase homolog 3 2 2
MIRT453824 SAA1 serum amyloid A1 2 2
MIRT454136 FOXRED2 FAD dependent oxidoreductase domain containing 2 2 2
MIRT455104 NKX2-2 NK2 homeobox 2 2 6
MIRT455250 DDX39B DExD-box helicase 39B 2 10
MIRT456899 DDA1 DET1 and DDB1 associated 1 2 2
MIRT457099 DCX doublecortin 2 2
MIRT457761 ZC3H12B zinc finger CCCH-type containing 12B 2 4
MIRT458539 CYP2B6 cytochrome P450 family 2 subfamily B member 6 2 2
MIRT459011 UQCRH ubiquinol-cytochrome c reductase hinge protein 2 2
MIRT459197 RCE1 Ras converting CAAX endopeptidase 1 2 2
MIRT459295 PHYKPL 5-phosphohydroxy-L-lysine phospho-lyase 2 2
MIRT459466 MUC17 mucin 17, cell surface associated 2 4
MIRT459598 KCNK3 potassium two pore domain channel subfamily K member 3 2 2
MIRT461274 COX10 COX10, heme A:farnesyltransferase cytochrome c oxidase assembly factor 2 2
MIRT464551 UBTF upstream binding transcription factor, RNA polymerase I 2 2
MIRT465253 TRIM44 tripartite motif containing 44 2 2
MIRT465274 TRIM28 tripartite motif containing 28 2 2
MIRT465402 TP53 tumor protein p53 2 2
MIRT465877 TMEM43 transmembrane protein 43 2 4
MIRT466234 TMED10 transmembrane p24 trafficking protein 10 2 2
MIRT467027 SRSF1 serine and arginine rich splicing factor 1 2 4
MIRT468320 SF3B3 splicing factor 3b subunit 3 2 2
MIRT468437 SETD1B SET domain containing 1B 2 2
MIRT468691 SEC22C SEC22 homolog C, vesicle trafficking protein 2 4
MIRT468863 RREB1 ras responsive element binding protein 1 2 2
MIRT469779 RAB15 RAB15, member RAS oncogene family 2 2
MIRT470314 PPP6R1 protein phosphatase 6 regulatory subunit 1 2 2
MIRT470765 PNPLA6 patatin like phospholipase domain containing 6 2 2
MIRT472213 NGFR nerve growth factor receptor 2 2
MIRT472520 NACC1 nucleus accumbens associated 1 2 2
MIRT473281 MFRP membrane frizzled-related protein 2 2
MIRT473403 MDM4 MDM4, p53 regulator 2 2
MIRT473521 MAX MYC associated factor X 2 2
MIRT474529 KLHDC8A kelch domain containing 8A 2 2
MIRT474631 KLF16 Kruppel like factor 16 2 2
MIRT475130 IP6K1 inositol hexakisphosphate kinase 1 2 2
MIRT475808 HDGF heparin binding growth factor 2 2
MIRT478623 CTDNEP1 CTD nuclear envelope phosphatase 1 2 2
MIRT479501 CDH6 cadherin 6 2 2
MIRT479865 CCDC6 coiled-coil domain containing 6 2 2
MIRT480132 CALR calreticulin 2 2
MIRT480529 C10orf76 chromosome 10 open reading frame 76 2 2
MIRT480774 BMP2 bone morphogenetic protein 2 2 2
MIRT481423 ASB6 ankyrin repeat and SOCS box containing 6 2 2
MIRT481778 APEX1 apurinic/apyrimidinic endodeoxyribonuclease 1 2 2
MIRT481821 AP2M1 adaptor related protein complex 2 mu 1 subunit 2 2
MIRT482698 XRCC3 X-ray repair cross complementing 3 2 2
MIRT482976 CSTF2 cleavage stimulation factor subunit 2 2 2
MIRT483391 SPATA6 spermatogenesis associated 6 2 4
MIRT483429 RHOXF2B Rhox homeobox family member 2B 2 2
MIRT483476 STMN3 stathmin 3 2 4
MIRT483687 CYP11A1 cytochrome P450 family 11 subfamily A member 1 2 2
MIRT483803 CYP2W1 cytochrome P450 family 2 subfamily W member 1 2 6
MIRT484335 EPN1 epsin 1 2 4
MIRT484683 PACSIN1 protein kinase C and casein kinase substrate in neurons 1 2 2
MIRT484966 UCK1 uridine-cytidine kinase 1 2 2
MIRT485987 YIPF2 Yip1 domain family member 2 2 2
MIRT486773 SESTD1 SEC14 and spectrin domain containing 1 2 4
MIRT487372 C10orf54 V-set immunoregulatory receptor 2 2
MIRT487632 ONECUT3 one cut homeobox 3 2 4
MIRT488080 DLGAP3 DLG associated protein 3 2 4
MIRT488158 PRRC2B proline rich coiled-coil 2B 2 4
MIRT488463 B3GALNT2 beta-1,3-N-acetylgalactosaminyltransferase 2 2 2
MIRT490948 PPM1F protein phosphatase, Mg2+/Mn2+ dependent 1F 2 2
MIRT491719 RTN4R reticulon 4 receptor 2 2
MIRT492338 SEPT8 septin 8 2 2
MIRT493038 NAA50 N(alpha)-acetyltransferase 50, NatE catalytic subunit 2 2
MIRT493368 KIAA1614 KIAA1614 2 2
MIRT499384 PLCG2 phospholipase C gamma 2 2 11
MIRT499596 ANKRD45 ankyrin repeat domain 45 2 2
MIRT499730 USH1G USH1 protein network component sans 2 4
MIRT500357 ZNF385A zinc finger protein 385A 2 2
MIRT501691 PCGF3 polycomb group ring finger 3 2 6
MIRT504502 PPP1R9B protein phosphatase 1 regulatory subunit 9B 2 2
MIRT509579 HIST2H2AB histone cluster 2 H2A family member b 2 4
MIRT510610 TPM3 tropomyosin 3 2 2
MIRT512803 GLRX glutaredoxin 2 2
MIRT513302 SETBP1 SET binding protein 1 2 2
MIRT514005 CECR2 CECR2, histone acetyl-lysine reader 2 4
MIRT515701 ZNF321P zinc finger protein 321, pseudogene 2 2
MIRT518260 LEAP2 liver enriched antimicrobial peptide 2 2 2
MIRT523183 HIST3H3 histone cluster 3 H3 2 2
MIRT524051 DNAJC8 DnaJ heat shock protein family (Hsp40) member C8 2 2
MIRT538642 CCSAP centriole, cilia and spindle associated protein 2 2
MIRT541497 ADM adrenomedullin 2 2
MIRT569279 PTPRF protein tyrosine phosphatase, receptor type F 2 2
MIRT570279 ARPC3 actin related protein 2/3 complex subunit 3 2 2
MIRT570326 ZBTB7A zinc finger and BTB domain containing 7A 2 2
MIRT571451 YKT6 YKT6 v-SNARE homolog 2 2
MIRT571597 TOB2 transducer of ERBB2, 2 2 2
MIRT574894 Plcg2 phospholipase C, gamma 2 2 7
MIRT607551 GLI2 GLI family zinc finger 2 2 2
MIRT607694 MAPK10 mitogen-activated protein kinase 10 2 2
MIRT609983 PPARA peroxisome proliferator activated receptor alpha 2 2
MIRT610076 CRLF1 cytokine receptor like factor 1 2 2
MIRT610578 CACUL1 CDK2 associated cullin domain 1 2 4
MIRT626322 LRTOMT leucine rich transmembrane and O-methyltransferase domain containing 2 2
MIRT634011 RIF1 replication timing regulatory factor 1 2 2
MIRT642680 KRT74 keratin 74 2 2
MIRT689717 ATXN2 ataxin 2 2 2
MIRT691175 APOL6 apolipoprotein L6 2 2
MIRT693169 NPR1 natriuretic peptide receptor 1 2 2
MIRT697121 OTUD5 OTU deubiquitinase 5 2 2
MIRT711817 ELN elastin 2 2
MIRT721551 FXN frataxin 2 2
MIRT721666 SLFN12 schlafen family member 12 2 2
MIRT723760 NKIRAS2 NFKB inhibitor interacting Ras like 2 2 2
MIRT737362 FOXP4 forkhead box P4 2 0
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-4 Dexamethasone approved 5743 Microarray primary rat thymocytes 20847043 2010 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-4651 Platinum 23939 sensitive High Ovarian Cancer tissue
hsa-miR-4651 Imatinib 5291 NSC743414 approved sensitive High Gastrointestinal Stromal Tumor cell line (882R-NC, 882R-OE, 882R-KD)
hsa-miR-4651 Cisplatin 5460033 NSC119875 approved resistant High Pancreatic Cancer cell line (BxPC-3)
hsa-miR-4651 Dabrafenib 44462760 NSC764134 approved resistant High Melanoma cell line (A375, IGR37, 501Mel)
hsa-miR-4651 Vemurafenib 42611257 NSC761431 approved resistant High Melanoma cell line (A375, IGR37, 501Mel)
hsa-miR-4651 Curcumin 969516 NSC32982 approved sensitive High Breast Cancer cell line (MCF-7)
hsa-miR-4651 Doxorubicin 31703 NSC123127 approved sensitive High Breast Cancer cell line (MCF-7)
hsa-miR-4651 Paclitaxel 36314 NSC125973 approved resistant High Non-Small Cell Lung Cancer cell line (A549)
hsa-miR-4651 Fulvestrant 17756771 NSC719276 approved resistant High Breast Cancer cell line (MCF-7)
hsa-mir-4651 Dabrafenib 44462760 NSC764134 approved resistant cell line (A375)
hsa-mir-4651 Cisplatin 5460033 NSC119875 approved resistant cell line (BxPC3)
hsa-miR-4651 Osimertinib 71496458 NSC779217 approved resistant cell line (PC9)
hsa-miR-4651 Cisplatin 5460033 NSC119875 approved resistant cell line (CAL-27) (cytosolic RNA)
hsa-miR-4651 Cisplatin 5460033 NSC119875 approved resistant cell line (CAL-27) (total RNA)
hsa-miR-4651 Cisplatin 5460033 NSC119875 approved sensitive cell line
hsa-miR-4651 Doxorubicin 31703 NSC123127 approved resistant cell line (HS578T)
hsa-miR-4651 Doxorubicin 31703 NSC123127 approved resistant cell line (BAS)
hsa-miR-4651 Cisplatin 5460033 NSC119875 approved resistant cell line (CIS)
hsa-miR-4651 Cisplatin 5460033 NSC119875 approved resistant cell line (CP20)
hsa-miR-4651 Osimertinib 71496458 NSC779217 approved sensitive cell line (H1975)
hsa-miR-4651 Vemurafenib 42611257 NSC761431 approved sensitive cell line (LM16)
hsa-miR-4651 Neoadjuvant chemotherapy sensitive tissue (breast cancer)
hsa-miR-4651 Neoadjuvant chemotherapy sensitive tissue (breast cancer)
hsa-miR-4651 Gemcitabine 60750 NSC613327 approved resistant cell line (PANC-1) (1500 ng/ml)
hsa-miR-4651 Gemcitabine 60750 NSC613327 approved resistant cell line (PANC-1) (100 ng/ml)
hsa-miR-4651 Gemcitabine 60750 NSC613327 approved resistant cell line (Panc1-GR4)

Error report submission