miRTarBase - #MIRT452851


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pre-miRNA Information
pre-miRNA hsa-mir-1273h   
Genomic Coordinates chr16: 24203116 - 24203231
Description Homo sapiens miR-1273h stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-1273h-5p
Sequence 33| CUGGGAGGUCAAGGCUGCAGU |53
Evidence Experimental
Experiments Illumina
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1028034199 14 dbSNP
rs542383563 18 dbSNP
Putative Targets

miRNA Expression profile
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol LAX1   
Synonyms LAX
Description lymphocyte transmembrane adaptor 1
Transcript NM_001136190   
Other Transcripts NM_017773   
Expression
Putative miRNA Targets on LAX1
3'UTR of LAX1
(miRNA target sites are highlighted)		 
>LAX1|NM_001136190|3'UTR
   1 AGACCCAGGTACCCAGCCATAAAGCCACATTGAGTAGTCTATCCCATAGGATTGACTACTGCAGAGTCTAGTGCAGACCC
  81 GTGATCACCTTAGTGCTTCAGTGGATTCACTGGTTAGATTAAAAAGAGGCTGAGATGAGCAGTGAACTAAGAGGCCACAC
 161 AAAAGCAGAGGTTTGGGAATTCCAGAAGGGAATTCTTCTCAAGCAGAGTGTGGTTATCTCCTGTACCAGCCTAAGAATGT
 241 TTGCTGAAACTGCTTCCTAGAACTGTGAAGAAAGCAGGAAAGTAGTGCACAGTAGTCTAAGATTATTACCTTCATTAATA
 321 CCAACAGGCTGCAAAGCAAGAGTATAGATTATTGTATAATCCAGTCAGAGGTCAAAAGGAAGGAAGAAGTTGGAGTGGAG
 401 TGGGGTGGGCAATTTCCATTTTAAAGAGTGTAGGCAGGCCAGGTGCAGTGGCTCATGCCTGTAATCCCAGCATTTTGGTA
 481 GGCCGAGGAGGGCAGATCACTTGGTGCCAGGAGTTCTAGACCAGCCTGGCCAACATGACCCATCTTTACTAAAAATACAA
 561 AAATTAGCCAGGCGTGGTGGTGTGCCCCTGTAATCCCAGCTACTCAGGAGGCTGAAGCAGGAGAATCGCTTGAACCCGGG
 641 AGGTGGAGGTTGCAGCAAGCCGAGATTGTGCCACTGTACTCCAGCCTGGTGACAGAGCGAGACTCCCTCTCAAAAAAAAA
 721 AACAAACAAAAAAGAAGTGTGGGCAACCAAATGTAGGTAAGGATGAAGAAGAACAGGAACTCTCACTGGTGGCTGATGGG
 801 ATTGCAAAGCGTCAGGGCAGCTTTGAAAAACTTTTCAGCAGTTTCTTATAAGCATAACTTATCATATGGCCCAGCCATTT
 881 CACTACTAGAAATTGACGCAAGTGAACTGAAAACTTATGTTCACACAAAAACTCGCACATGACTGTTTATAGCAGCTTCA
 961 TTCATAATTACCAAAAACTAGAAATAACCCAGATATCCTTCAACAGGTGATTGGATAAGCTGTTGATATCCATTCCTTGA
1041 GTTTATCCATACTCAACAGTAAAAAATGAACTCTTGGTTCACACAATAATATAGACATATCTTAAATCCATTTTGCTAAG
1121 TGAAAGAAGCTAGGCCTAAAAGTCTACATGTTGGGCGATTCTATTTATATGACATTCTGGAAAAGGCAAAACTATAGGGA
1201 TGAAGAACAGATCAGTTGTTGTCAGGTTTGAGAAAAGGAGGGAAGTTTGCTACAAAGGGGCTGCAAAGGGAATAGGCTGA
1281 TGGAGCTGTTCTGTATGGTACTGTGTGGTGGATACATGACAATATCCATTTGCAAACACAAGAACTATACACATGGCCAG
1361 GCGCGGTGGCTCACACCCGTAATCCCAGCACTTTGCGGGGCCGAGGCAGGGGAACACAAGGTCAGGAGATCAAGACTGTC
1441 CTGGACAACATGGTGAAACCCTGTCTCTACTGTCTCTAACATTTGTAAACCTGTCTCTAATTTGTAATTTGTAAACCCTG
1521 TCTCTCATATTTGTAAAACTACAAAAATTAGCTTGGCATGGTGGTGTGCGCCTGTAGTCCCAGCTACTAGGAGGCTGAGG
1601 CAGGAGAATCACTTGAACCAGGAAGGCGGACTGCATTCCAGCCTGGGCAACAGAGAAAGACTCTGTCTCAAAAAAAAAAA
1681 AAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' ugaCG-UCGGAACUGGAGGGUc 5'
             || || ||   ||||:|| 
Target 5' agaGCGAGACT--CCCTCTCAa 3'
 694 - 713 130.00 -11.00
2 
miRNA  3' ugaCGUCGGAAC----UGGAGGGUc 5'
             |||||:|||    ||:|::|| 
Target 5' aggGCAGCTTTGAAAAACTTTTCAg 3'
 814 - 838 124.00 -21.40
3 
miRNA  3' ugACG-UCGGAACUGGAGGGUc 5'
            ||: | || || :|||:|| 
Target 5' ttTGTAAACCCTG-TCTCTCAt 3'
 1508 - 1528 122.00 -11.40
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30153412 33 COSMIC
COSN30177813 93 COSMIC
COSN31507928 111 COSMIC
COSN30534132 150 COSMIC
COSN30121618 166 COSMIC
COSN20625385 240 COSMIC
COSN5736665 263 COSMIC
COSN21790104 444 COSMIC
COSN24103581 597 COSMIC
COSN24802284 699 COSMIC
COSN22449195 1380 COSMIC
COSN8969090 1385 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs762327821 3 dbSNP
rs767917448 4 dbSNP
rs749911662 5 dbSNP
rs755603110 7 dbSNP
rs779833013 8 dbSNP
rs1424845888 10 dbSNP
rs201124327 12 dbSNP
rs1187617655 17 dbSNP
rs979357356 20 dbSNP
rs376171819 21 dbSNP
rs754817096 29 dbSNP
rs1239655624 30 dbSNP
rs146967153 31 dbSNP
rs988011282 33 dbSNP
rs369197628 35 dbSNP
rs749081246 38 dbSNP
rs771977212 40 dbSNP
rs777601457 46 dbSNP
rs534298038 47 dbSNP
rs1318845643 53 dbSNP
rs918000429 56 dbSNP
rs949528152 71 dbSNP
rs1292475219 82 dbSNP
rs543825735 86 dbSNP
rs35620783 88 dbSNP
rs1231186784 105 dbSNP
rs1045052482 125 dbSNP
rs1381261605 127 dbSNP
rs569206573 131 dbSNP
rs1284654503 138 dbSNP
rs183615928 140 dbSNP
rs1352298310 156 dbSNP
rs1332761162 158 dbSNP
rs942265934 162 dbSNP
rs1270005072 165 dbSNP
rs1164663884 166 dbSNP
rs1422371974 170 dbSNP
rs551527214 181 dbSNP
rs144928231 193 dbSNP
rs369292080 193 dbSNP
rs1037922295 194 dbSNP
rs1470047361 210 dbSNP
rs1204377292 211 dbSNP
rs1231303191 219 dbSNP
rs1180536687 223 dbSNP
rs913088332 225 dbSNP
rs1447258735 227 dbSNP
rs1272710587 230 dbSNP
rs898124679 246 dbSNP
rs968427787 259 dbSNP
rs1323349622 265 dbSNP
rs1452930122 276 dbSNP
rs993620448 277 dbSNP
rs978516001 279 dbSNP
rs1371024915 284 dbSNP
rs1199143119 294 dbSNP
rs188406178 297 dbSNP
rs1051912714 316 dbSNP
rs890862569 317 dbSNP
rs1245553228 318 dbSNP
rs1479207767 320 dbSNP
rs1008412505 330 dbSNP
rs1184948260 333 dbSNP
rs1323547962 335 dbSNP
rs1017911717 346 dbSNP
rs899505431 347 dbSNP
rs1000744658 350 dbSNP
rs937020738 356 dbSNP
rs191616718 363 dbSNP
rs956641711 373 dbSNP
rs987958693 378 dbSNP
rs918164135 380 dbSNP
rs1440338373 388 dbSNP
rs1025250187 397 dbSNP
rs144881505 398 dbSNP
rs769361909 400 dbSNP
rs1393355109 402 dbSNP
rs970812191 406 dbSNP
rs1047863519 408 dbSNP
rs1214729937 419 dbSNP
rs1315091151 427 dbSNP
rs1288013779 432 dbSNP
rs1240759347 440 dbSNP
rs1346577194 443 dbSNP
rs1300619584 444 dbSNP
rs4951198 450 dbSNP
rs1378918621 455 dbSNP
rs1367796769 462 dbSNP
rs1343705975 464 dbSNP
rs1411800593 477 dbSNP
rs1294492988 478 dbSNP
rs1290108254 484 dbSNP
rs926608663 486 dbSNP
rs149045342 487 dbSNP
rs755974005 498 dbSNP
rs1420804844 502 dbSNP
rs1037746217 506 dbSNP
rs1173976063 514 dbSNP
rs1284168094 515 dbSNP
rs1435135718 517 dbSNP
rs143181094 536 dbSNP
rs575294166 537 dbSNP
rs973411738 538 dbSNP
rs148262633 539 dbSNP
rs1265023604 545 dbSNP
rs1217335320 556 dbSNP
rs1485296280 558 dbSNP
rs929584744 559 dbSNP
rs1234697770 564 dbSNP
rs1051916399 574 dbSNP
rs140394232 575 dbSNP
rs943769090 586 dbSNP
rs1212412775 591 dbSNP
rs1338951096 596 dbSNP
rs890354505 606 dbSNP
rs1290650580 607 dbSNP
rs1401162961 621 dbSNP
rs1039862988 628 dbSNP
rs1375307307 629 dbSNP
rs1010169662 636 dbSNP
rs899619461 638 dbSNP
rs761413242 639 dbSNP
rs1170060416 640 dbSNP
rs1032038521 644 dbSNP
rs34412467 649 dbSNP
rs978632184 650 dbSNP
rs1034095762 662 dbSNP
rs540538090 663 dbSNP
rs1009504318 672 dbSNP
rs1024778552 677 dbSNP
rs970972992 687 dbSNP
rs980672247 690 dbSNP
rs1473365173 698 dbSNP
rs560373742 699 dbSNP
rs529448132 700 dbSNP
rs1363992878 710 dbSNP
rs1441171727 712 dbSNP
rs751408243 712 dbSNP
rs983668384 712 dbSNP
rs79721099 713 dbSNP
rs942193090 714 dbSNP
rs12566161 719 dbSNP
rs57094739 719 dbSNP
rs147486513 720 dbSNP
rs201519369 720 dbSNP
rs973359501 722 dbSNP
rs1249230249 723 dbSNP
rs919278453 724 dbSNP
rs1176165645 728 dbSNP
rs1390679846 729 dbSNP
rs1038303048 732 dbSNP
rs1342026545 734 dbSNP
rs900565184 735 dbSNP
rs1245303010 742 dbSNP
rs1356142669 743 dbSNP
rs1247700504 744 dbSNP
rs1341532651 764 dbSNP
rs1313883159 774 dbSNP
rs1356773125 775 dbSNP
rs767231934 784 dbSNP
rs778490487 791 dbSNP
rs929532296 793 dbSNP
rs1379420061 799 dbSNP
rs1480064028 800 dbSNP
rs138040183 808 dbSNP
rs912025716 810 dbSNP
rs943530413 811 dbSNP
rs747505097 812 dbSNP
rs1363123711 818 dbSNP
rs866653152 819 dbSNP
rs879166091 821 dbSNP
rs1156331610 822 dbSNP
rs1020211526 830 dbSNP
rs1238222047 841 dbSNP
rs904475665 858 dbSNP
rs1183330377 859 dbSNP
rs921000709 863 dbSNP
rs936428454 877 dbSNP
rs1265723323 878 dbSNP
rs1383804770 883 dbSNP
rs538502841 886 dbSNP
rs1169476324 894 dbSNP
rs34200339 897 dbSNP
rs1285869489 898 dbSNP
rs6685890 899 dbSNP
rs553934490 904 dbSNP
rs892148046 933 dbSNP
rs531748545 935 dbSNP
rs1046744196 936 dbSNP
rs551831881 940 dbSNP
rs906487811 951 dbSNP
rs1325320949 958 dbSNP
rs1404314686 962 dbSNP
rs1002434989 963 dbSNP
rs1387089527 965 dbSNP
rs372417046 967 dbSNP
rs1383948260 969 dbSNP
rs1396566537 972 dbSNP
rs1421440459 988 dbSNP
rs1335779842 989 dbSNP
rs1033543220 992 dbSNP
rs571573582 999 dbSNP
rs1230070802 1004 dbSNP
rs1297952470 1006 dbSNP
rs1306391810 1007 dbSNP
rs527652049 1015 dbSNP
rs963407738 1021 dbSNP
rs994896477 1022 dbSNP
rs1023942569 1027 dbSNP
rs1201489773 1030 dbSNP
rs1452595072 1034 dbSNP
rs1262877450 1040 dbSNP
rs1257280432 1053 dbSNP
rs1215166169 1059 dbSNP
rs1489546801 1069 dbSNP
rs951046467 1083 dbSNP
rs1483838256 1093 dbSNP
rs1218684728 1094 dbSNP
rs12075158 1095 dbSNP
rs1026238724 1097 dbSNP
rs546928079 1098 dbSNP
rs950722370 1099 dbSNP
rs1276883723 1101 dbSNP
rs987528122 1118 dbSNP
rs912123091 1119 dbSNP
rs566728234 1137 dbSNP
rs965017699 1140 dbSNP
rs1401781274 1143 dbSNP
rs975297590 1145 dbSNP
rs1332966297 1149 dbSNP
rs926125515 1151 dbSNP
rs535747279 1155 dbSNP
rs770011153 1157 dbSNP
rs1053539275 1158 dbSNP
rs142024843 1166 dbSNP
rs1423421149 1170 dbSNP
rs1178275512 1173 dbSNP
rs146340279 1180 dbSNP
rs1264472773 1186 dbSNP
rs1470201903 1187 dbSNP
rs973572442 1196 dbSNP
rs1175622166 1215 dbSNP
rs77198318 1219 dbSNP
rs1046095370 1220 dbSNP
rs906426207 1221 dbSNP
rs1317462350 1233 dbSNP
rs1437071323 1242 dbSNP
rs1002147601 1243 dbSNP
rs1320777939 1246 dbSNP
rs1054856045 1254 dbSNP
rs899013009 1259 dbSNP
rs1360792440 1260 dbSNP
rs1341076669 1264 dbSNP
rs994842666 1265 dbSNP
rs1380193802 1270 dbSNP
rs932050164 1275 dbSNP
rs1026354172 1276 dbSNP
rs1341813179 1277 dbSNP
rs1312274612 1278 dbSNP
rs950836387 1280 dbSNP
rs74988844 1299 dbSNP
rs1223439036 1303 dbSNP
rs1397589306 1305 dbSNP
rs1261873700 1306 dbSNP
rs1169018392 1311 dbSNP
rs1331635044 1312 dbSNP
rs1018969468 1313 dbSNP
rs59804556 1314 dbSNP
rs765744538 1317 dbSNP
rs1472089261 1318 dbSNP
rs1239302011 1330 dbSNP
rs79558575 1331 dbSNP
rs926075062 1332 dbSNP
rs946023304 1333 dbSNP
rs544216669 1334 dbSNP
rs957526062 1339 dbSNP
rs1193150968 1342 dbSNP
rs753991472 1346 dbSNP
rs1288873617 1347 dbSNP
rs1041769754 1363 dbSNP
rs1358304638 1364 dbSNP
rs1284276357 1365 dbSNP
rs542326536 1366 dbSNP
rs760588168 1375 dbSNP
rs10900475 1376 dbSNP
rs1447059793 1379 dbSNP
rs894311063 1380 dbSNP
rs1427167245 1382 dbSNP
rs753593205 1386 dbSNP
rs1300137223 1387 dbSNP
rs1164319671 1394 dbSNP
rs373541894 1397 dbSNP
rs982162981 1398 dbSNP
rs1458370621 1401 dbSNP
rs927665405 1403 dbSNP
rs778571977 1404 dbSNP
rs1453284032 1411 dbSNP
rs1344405650 1418 dbSNP
rs1054968614 1419 dbSNP
rs1451097458 1422 dbSNP
rs1350958297 1423 dbSNP
rs899128001 1424 dbSNP
rs1310799638 1433 dbSNP
rs930469805 1439 dbSNP
rs752279161 1441 dbSNP
rs557900199 1449 dbSNP
rs1293341384 1451 dbSNP
rs779389939 1456 dbSNP
rs575668763 1460 dbSNP
rs968003470 1470 dbSNP
rs1304320779 1472 dbSNP
rs1009001077 1495 dbSNP
rs963567990 1497 dbSNP
rs1378608166 1514 dbSNP
rs1160467375 1515 dbSNP
rs1019332843 1517 dbSNP
rs1424672198 1520 dbSNP
rs1189675172 1521 dbSNP
rs11240418 1522 dbSNP
rs9792973 1540 dbSNP
rs953663975 1545 dbSNP
rs1229570646 1551 dbSNP
rs1287547840 1557 dbSNP
rs1283929845 1561 dbSNP
rs987696127 1562 dbSNP
rs1298800701 1565 dbSNP
rs777386513 1570 dbSNP
rs957639957 1571 dbSNP
rs149572629 1572 dbSNP
rs533682880 1573 dbSNP
rs1359106564 1578 dbSNP
rs1300147709 1603 dbSNP
rs1266311398 1605 dbSNP
rs1020484836 1607 dbSNP
rs1490198453 1612 dbSNP
rs966835499 1613 dbSNP
rs981893641 1616 dbSNP
rs1429757903 1618 dbSNP
rs144238057 1625 dbSNP
rs1476818359 1626 dbSNP
rs531906018 1628 dbSNP
rs545186530 1629 dbSNP
rs1482665570 1633 dbSNP
rs1253734728 1646 dbSNP
rs1406978355 1652 dbSNP
rs1312351739 1658 dbSNP
rs565342333 1660 dbSNP
rs1056122731 1661 dbSNP
rs1218357428 1661 dbSNP
rs920498439 1662 dbSNP
rs1417148305 1663 dbSNP
rs1166439581 1668 dbSNP
rs1339120821 1668 dbSNP
rs1280697494 1669 dbSNP
rs1378615754 1669 dbSNP
rs1383267647 1669 dbSNP
rs750543040 1669 dbSNP
rs775126412 1669 dbSNP
rs1193892969 1670 dbSNP
rs1196338102 1670 dbSNP
rs1237134952 1670 dbSNP
rs1253478768 1670 dbSNP
rs1407060681 1670 dbSNP
rs1423160751 1670 dbSNP
rs1425464195 1670 dbSNP
rs1463915175 1670 dbSNP
rs1467780103 1670 dbSNP
rs61192784 1670 dbSNP
rs768341425 1670 dbSNP
rs772033401 1670 dbSNP
rs778803558 1670 dbSNP
rs869071574 1670 dbSNP
rs1365848333 1677 dbSNP
rs1316517075 1682 dbSNP
rs894433700 1683 dbSNP
rs1228816929 1684 dbSNP
rs930585710 1685 dbSNP
rs1014488351 1686 dbSNP
rs1045571996 1688 dbSNP
rs1330981468 1688 dbSNP
rs1047530328 1689 dbSNP
rs1300687855 1689 dbSNP
rs886286931 1690 dbSNP
rs1443476787 1692 dbSNP
rs886831598 1692 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions TZM-bl
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM1462574. RNA binding protein: AGO2. Condition:TZM-bl ami BaL ...

- Whisnant AW; Bogerd HP; Flores O; Ho P; et al., 2013, mBio.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' ugacgucggaacuGGAGGGUc 5'
                       ||||||| 
Target 5' -------------CCUCCCAa 3'
 		1 - 8
Article - Whisnant AW; Bogerd HP; Flores O; Ho P; et al.
- mBio, 2013
UNLABELLED: The question of how HIV-1 interfaces with cellular microRNA (miRNA) biogenesis and effector mechanisms has been highly controversial. Here, we first used deep sequencing of small RNAs present in two different infected cell lines (TZM-bl and C8166) and two types of primary human cells (CD4(+) peripheral blood mononuclear cells [PBMCs] and macrophages) to unequivocally demonstrate that HIV-1 does not encode any viral miRNAs. Perhaps surprisingly, we also observed that infection of T cells by HIV-1 has only a modest effect on the expression of cellular miRNAs at early times after infection. Comprehensive analysis of miRNA binding to the HIV-1 genome using the photoactivatable ribonucleoside-induced cross-linking and immunoprecipitation (PAR-CLIP) technique revealed several binding sites for cellular miRNAs, a subset of which were shown to be capable of mediating miRNA-mediated repression of gene expression. However, the main finding from this analysis is that HIV-1 transcripts are largely refractory to miRNA binding, most probably due to extensive viral RNA secondary structure. Together, these data demonstrate that HIV-1 neither encodes viral miRNAs nor strongly influences cellular miRNA expression, at least early after infection, and imply that HIV-1 transcripts have evolved to avoid inhibition by preexisting cellular miRNAs by adopting extensive RNA secondary structures that occlude most potential miRNA binding sites. IMPORTANCE: MicroRNAs (miRNAs) are a ubiquitous class of small regulatory RNAs that serve as posttranscriptional regulators of gene expression. Previous work has suggested that HIV-1 might subvert the function of the cellular miRNA machinery by expressing viral miRNAs or by dramatically altering the level of cellular miRNA expression. Using very sensitive approaches, we now demonstrate that neither of these ideas is in fact correct. Moreover, HIV-1 transcripts appear to largely avoid regulation by cellular miRNAs by adopting an extensive RNA secondary structure that occludes the ability of cellular miRNAs to interact with viral mRNAs. Together, these data suggest that HIV-1, rather than seeking to control miRNA function in infected cells, has instead evolved a mechanism to become largely invisible to cellular miRNA effector mechanisms.
LinkOut: [PMID: 23592263]
Experimental Support 2 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions Prostate Tissue
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in SRX1760630. RNA binding protein: AGO2. Condition:AGO-CLIP-22RV1_A ...

- Hamilton MP; Rajapakshe KI; Bader DA; Cerne et al., 2016, Neoplasia (New York, N.Y.).

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' ugACGUCGGAACUGGAGGGuc 5'
            |||| |||  |||||||  
Target 5' acUGCAACCUCCACCUCCC-- 3'
 		15 - 33
Article - Hamilton MP; Rajapakshe KI; Bader DA; Cerne et al.
- Neoplasia (New York, N.Y.), 2016
MicroRNA (miRNA) deregulation in prostate cancer (PCa) contributes to PCa initiation and metastatic progression. To comprehensively define the cancer-associated changes in miRNA targeting and function in commonly studied models of PCa, we performed photoactivatable ribonucleoside-enhanced cross-linking immunoprecipitation of the Argonaute protein in a panel of PCa cell lines modeling different stages of PCa progression. Using this comprehensive catalogue of miRNA targets, we analyzed miRNA targeting on known drivers of PCa and examined tissue-specific and stage-specific pathway targeting by miRNAs. We found that androgen receptor is the most frequently targeted PCa oncogene and that miR-148a targets the largest number of known PCa drivers. Globally, tissue-specific and stage-specific changes in miRNA targeting are driven by homeostatic response to active oncogenic pathways. Our findings indicate that, even in advanced PCa, the miRNA pool adapts to regulate continuing alterations in the cancer genome to balance oncogenic molecular changes. These findings are important because they are the first to globally characterize miRNA changes in PCa and demonstrate how the miRNA target spectrum responds to staged tumorigenesis.
LinkOut: [PMID: 27292025]
CLIP-seq Support 1 for dataset GSM1462574
Method / RBP PAR-CLIP / AGO2
Cell line / Condition TZM-bl / TZM-bl ami BaL
Location of target site ENST00000442561.2 | 3UTR | CCUCCCAAGUUCAAGCAAUUCUCCUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23592263 / GSE59944
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
494 hsa-miR-1273h-5p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT074355 TNRC6A trinucleotide repeat containing 6A 2 2
MIRT100721 TJAP1 tight junction associated protein 1 2 2
MIRT115545 MAZ MYC associated zinc finger protein 2 2
MIRT124982 XIAP X-linked inhibitor of apoptosis 2 4
MIRT139911 BTF3L4 basic transcription factor 3 like 4 2 6
MIRT177183 ARL5B ADP ribosylation factor like GTPase 5B 2 4
MIRT187994 MBD6 methyl-CpG binding domain protein 6 2 2
MIRT207410 MAT2A methionine adenosyltransferase 2A 2 6
MIRT241928 DYRK2 dual specificity tyrosine phosphorylation regulated kinase 2 2 2
MIRT260110 KLHL21 kelch like family member 21 2 2
MIRT260358 XRCC6 X-ray repair cross complementing 6 2 6
MIRT266428 RPRD2 regulation of nuclear pre-mRNA domain containing 2 2 2
MIRT294663 ZNF548 zinc finger protein 548 2 2
MIRT351039 PLEKHB2 pleckstrin homology domain containing B2 2 2
MIRT379943 PRRG4 proline rich and Gla domain 4 2 2
MIRT398983 KAT7 lysine acetyltransferase 7 2 2
MIRT441465 BEST3 bestrophin 3 2 2
MIRT446750 ZNF491 zinc finger protein 491 2 2
MIRT449224 RAD51B RAD51 paralog B 2 2
MIRT450623 AQR aquarius intron-binding spliceosomal factor 2 2
MIRT451090 ZNF584 zinc finger protein 584 2 2
MIRT451558 CIAPIN1 cytokine induced apoptosis inhibitor 1 2 2
MIRT451736 CES3 carboxylesterase 3 2 2
MIRT452411 QDPR quinoid dihydropteridine reductase 2 2
MIRT452559 ZFP69B ZFP69 zinc finger protein B 2 2
MIRT452851 LAX1 lymphocyte transmembrane adaptor 1 2 2
MIRT452922 DISC1 disrupted in schizophrenia 1 2 2
MIRT453043 TANGO2 transport and golgi organization 2 homolog 2 4
MIRT453097 HOXC4 homeobox C4 2 2
MIRT453297 ZNF394 zinc finger protein 394 2 2
MIRT453593 ZNF557 zinc finger protein 557 2 2
MIRT453787 KBTBD12 kelch repeat and BTB domain containing 12 2 2
MIRT453987 CECR1 adenosine deaminase 2 2 2
MIRT454083 TMEM209 transmembrane protein 209 2 2
MIRT454652 FBXL18 F-box and leucine rich repeat protein 18 2 2
MIRT454753 PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 2 2
MIRT455311 TTLL9 tubulin tyrosine ligase like 9 2 2
MIRT456468 SERAC1 serine active site containing 1 2 2
MIRT456554 TOMM20 translocase of outer mitochondrial membrane 20 2 2
MIRT456716 TMEM239 transmembrane protein 239 2 4
MIRT456796 SIGLEC14 sialic acid binding Ig like lectin 14 2 2
MIRT457487 SLC35F6 solute carrier family 35 member F6 2 2
MIRT457999 MRPL12 mitochondrial ribosomal protein L12 2 2
MIRT458130 TLCD2 TLC domain containing 2 2 2
MIRT459027 ZNF490 zinc finger protein 490 2 4
MIRT459119 FADS6 fatty acid desaturase 6 2 2
MIRT459315 HAVCR2 hepatitis A virus cellular receptor 2 2 2
MIRT459385 MPLKIP M-phase specific PLK1 interacting protein 2 2
MIRT459412 FAM83B family with sequence similarity 83 member B 2 2
MIRT459974 RFT1 RFT1 homolog 2 2
MIRT460480 FAM105A family with sequence similarity 105 member A 2 6
MIRT460586 FEM1A fem-1 homolog A 2 2
MIRT460920 NOA1 nitric oxide associated 1 2 4
MIRT461072 OPA3 OPA3, outer mitochondrial membrane lipid metabolism regulator 2 2
MIRT461590 DPH2 DPH2 homolog 2 2
MIRT461854 ZNF317 zinc finger protein 317 2 2
MIRT462176 ACADL acyl-CoA dehydrogenase, long chain 2 2
MIRT462446 GCDH glutaryl-CoA dehydrogenase 2 2
MIRT463854 WNT7B Wnt family member 7B 2 2
MIRT464310 UST uronyl 2-sulfotransferase 2 2
MIRT464815 UBE2B ubiquitin conjugating enzyme E2 B 2 2
MIRT465453 TOR2A torsin family 2 member A 2 2
MIRT466073 TMEM184C transmembrane protein 184C 2 2
MIRT466514 TBXA2R thromboxane A2 receptor 2 2
MIRT467072 SRRD SRR1 domain containing 2 2
MIRT469551 RARA retinoic acid receptor alpha 2 2
MIRT469741 RAB2B RAB2B, member RAS oncogene family 2 2
MIRT470759 PNPLA6 patatin like phospholipase domain containing 6 2 2
MIRT470875 PLXND1 plexin D1 2 2
MIRT470976 PITPNA phosphatidylinositol transfer protein alpha 2 2
MIRT471048 PIM3 Pim-3 proto-oncogene, serine/threonine kinase 2 2
MIRT471215 PHAX phosphorylated adaptor for RNA export 2 2
MIRT471246 PGM2L1 phosphoglucomutase 2 like 1 2 2
MIRT471286 PGAM4 phosphoglycerate mutase family member 4 2 2
MIRT471467 PDE7B phosphodiesterase 7B 2 2
MIRT473069 MORN4 MORN repeat containing 4 2 4
MIRT473989 LRRC20 leucine rich repeat containing 20 2 2
MIRT474518 KLHDC8A kelch domain containing 8A 2 2
MIRT474990 KANSL1 KAT8 regulatory NSL complex subunit 1 2 2
MIRT475547 HNRNPUL1 heterogeneous nuclear ribonucleoprotein U like 1 2 2
MIRT476350 GIGYF1 GRB10 interacting GYF protein 1 2 2
MIRT477298 EPHB2 EPH receptor B2 2 2
MIRT477933 DPM2 dolichyl-phosphate mannosyltransferase subunit 2, regulatory 2 2
MIRT478282 DDX19A DEAD-box helicase 19A 2 4
MIRT478472 CYP20A1 cytochrome P450 family 20 subfamily A member 1 2 2
MIRT478559 CTNND1 catenin delta 1 2 2
MIRT478618 CTDNEP1 CTD nuclear envelope phosphatase 1 2 2
MIRT478834 CRISPLD2 cysteine rich secretory protein LCCL domain containing 2 2 2
MIRT479007 COL5A1 collagen type V alpha 1 chain 2 2
MIRT479166 CLSPN claspin 2 2
MIRT482454 ADAR adenosine deaminase, RNA specific 2 4
MIRT483019 KHSRP KH-type splicing regulatory protein 2 4
MIRT483798 CYP2W1 cytochrome P450 family 2 subfamily W member 1 2 6
MIRT486087 SLC7A5 solute carrier family 7 member 5 2 4
MIRT486304 SIPA1 signal-induced proliferation-associated 1 2 2
MIRT486490 MYH11 myosin heavy chain 11 2 2
MIRT486881 TSPYL4 TSPY like 4 2 2
MIRT487125 NCOR2 nuclear receptor corepressor 2 2 2
MIRT487542 TM6SF2 transmembrane 6 superfamily member 2 2 4
MIRT487676 B3GALT5 beta-1,3-galactosyltransferase 5 2 4
MIRT489251 TTLL1 tubulin tyrosine ligase like 1 2 4
MIRT489276 RBM8A RNA binding motif protein 8A 2 8
MIRT489496 CRLF3 cytokine receptor like factor 3 2 4
MIRT489571 SSBP2 single stranded DNA binding protein 2 2 2
MIRT489694 SCAMP4 secretory carrier membrane protein 4 2 2
MIRT490166 TMEM63C transmembrane protein 63C 2 2
MIRT491199 MLLT1 MLLT1, super elongation complex subunit 2 4
MIRT491260 DHX40 DEAH-box helicase 40 2 2
MIRT491385 HAUS3 HAUS augmin like complex subunit 3 2 2
MIRT491548 YAE1D1 Yae1 domain containing 1 2 2
MIRT492722 PHF12 PHD finger protein 12 2 2
MIRT493866 FAM73B mitoguardin 2 2 4
MIRT494549 BAK1 BCL2 antagonist/killer 1 2 2
MIRT498586 KRT8 keratin 8 2 2
MIRT498722 SNTN sentan, cilia apical structure protein 2 6
MIRT499982 HIST1H2BD histone cluster 1 H2B family member d 2 4
MIRT503414 SLC25A45 solute carrier family 25 member 45 2 6
MIRT508491 FTO FTO, alpha-ketoglutarate dependent dioxygenase 2 2
MIRT508877 METTL14 methyltransferase like 14 2 2
MIRT509622 RRP7A ribosomal RNA processing 7 homolog A 2 4
MIRT510104 IRAK3 interleukin 1 receptor associated kinase 3 2 8
MIRT510139 PDGFRA platelet derived growth factor receptor alpha 2 4
MIRT510353 ZNF703 zinc finger protein 703 2 6
MIRT510620 TMEM167A transmembrane protein 167A 2 4
MIRT510786 SF3B3 splicing factor 3b subunit 3 2 6
MIRT511021 NRF1 nuclear respiratory factor 1 2 2
MIRT513925 GHITM growth hormone inducible transmembrane protein 2 2
MIRT514342 DNAH17 dynein axonemal heavy chain 17 2 4
MIRT515015 SUMF2 sulfatase modifying factor 2 2 2
MIRT515246 DUSP28 dual specificity phosphatase 28 2 2
MIRT516202 RPP30 ribonuclease P/MRP subunit p30 2 2
MIRT516435 ADAMTS4 ADAM metallopeptidase with thrombospondin type 1 motif 4 2 4
MIRT516666 ZNF860 zinc finger protein 860 2 4
MIRT518373 ZNF250 zinc finger protein 250 2 2
MIRT518930 LSG1 large 60S subunit nuclear export GTPase 1 2 2
MIRT519676 ZNF70 zinc finger protein 70 2 2
MIRT519902 ZFAND4 zinc finger AN1-type containing 4 2 4
MIRT519945 ZCCHC8 zinc finger CCHC-type containing 8 2 2
MIRT520321 UBXN2A UBX domain protein 2A 2 2
MIRT520606 TMEM41B transmembrane protein 41B 2 2
MIRT520663 TMEM11 transmembrane protein 11 2 2
MIRT520852 SUGT1 SGT1 homolog, MIS12 kinetochore complex assembly cochaperone 2 2
MIRT521443 RAD51 RAD51 recombinase 2 2
MIRT521671 PRKAR2A protein kinase cAMP-dependent type II regulatory subunit alpha 2 2
MIRT522281 NKAP NFKB activating protein 2 2
MIRT522333 NCKIPSD NCK interacting protein with SH3 domain 2 8
MIRT522535 MED28 mediator complex subunit 28 2 6
MIRT523478 GNG4 G protein subunit gamma 4 2 2
MIRT523672 FOPNL FGFR1OP N-terminal like 2 2
MIRT523715 FBXW2 F-box and WD repeat domain containing 2 2 4
MIRT523867 ESCO2 establishment of sister chromatid cohesion N-acetyltransferase 2 2 4
MIRT524043 DNAJC8 DnaJ heat shock protein family (Hsp40) member C8 2 2
MIRT524167 DFFA DNA fragmentation factor subunit alpha 2 2
MIRT524928 ALG10B ALG10B, alpha-1,2-glucosyltransferase 2 2
MIRT526825 PHC1 polyhomeotic homolog 1 2 2
MIRT531017 TDGF1P3 teratocarcinoma-derived growth factor 1 pseudogene 3 2 2
MIRT536085 MBOAT2 membrane bound O-acyltransferase domain containing 2 2 2
MIRT540681 BMP3 bone morphogenetic protein 3 2 2
MIRT541708 TMEM33 transmembrane protein 33 2 2
MIRT541755 KLF8 Kruppel like factor 8 2 2
MIRT541888 LY6G5B lymphocyte antigen 6 family member G5B 2 2
MIRT545714 SPTLC2 serine palmitoyltransferase long chain base subunit 2 2 2
MIRT559054 C19orf47 chromosome 19 open reading frame 47 2 4
MIRT561748 PLAGL2 PLAG1 like zinc finger 2 2 2
MIRT562365 ETV3 ETS variant 3 2 2
MIRT562821 GCFC2 GC-rich sequence DNA-binding factor 2 2 2
MIRT562900 DNAH10OS dynein axonemal heavy chain 10 opposite strand 2 2
MIRT564452 SLC35E2 solute carrier family 35 member E2 2 5
MIRT569111 ONECUT3 one cut homeobox 3 2 2
MIRT569224 SUSD1 sushi domain containing 1 2 2
MIRT570271 ARPC3 actin related protein 2/3 complex subunit 3 2 2
MIRT570498 TFIP11 tuftelin interacting protein 11 2 2
MIRT570844 GPRC5C G protein-coupled receptor class C group 5 member C 2 2
MIRT571311 TPCN2 two pore segment channel 2 2 2
MIRT572077 EXOC8 exocyst complex component 8 2 2
MIRT572116 DNAJC24 DnaJ heat shock protein family (Hsp40) member C24 2 2
MIRT573054 TRIB1 tribbles pseudokinase 1 2 2
MIRT573483 IQSEC3 IQ motif and Sec7 domain 3 2 2
MIRT573656 HES6 hes family bHLH transcription factor 6 2 2
MIRT574343 ZBTB37 zinc finger and BTB domain containing 37 2 2
MIRT576494 Slc35e2 solute carrier family 35, member E2 2 4
MIRT608033 UBLCP1 ubiquitin like domain containing CTD phosphatase 1 2 2
MIRT611326 NANOS1 nanos C2HC-type zinc finger 1 2 2
MIRT613660 KIAA1210 KIAA1210 2 2
MIRT615638 ATF6 activating transcription factor 6 2 2
MIRT618573 RRAD RRAD, Ras related glycolysis inhibitor and calcium channel regulator 2 2
MIRT618865 MBL2 mannose binding lectin 2 2 2
MIRT618962 MRPS16 mitochondrial ribosomal protein S16 2 2
MIRT619172 SLC16A4 solute carrier family 16 member 4 2 2
MIRT620298 AQP6 aquaporin 6 2 2
MIRT620683 RFTN2 raftlin family member 2 2 2
MIRT621637 UBXN2B UBX domain protein 2B 2 2
MIRT621993 STK4 serine/threonine kinase 4 2 2
MIRT622421 NUDT19 nudix hydrolase 19 2 2
MIRT622804 PGAM5 PGAM family member 5, mitochondrial serine/threonine protein phosphatase 2 4
MIRT624786 AGAP9 ArfGAP with GTPase domain, ankyrin repeat and PH domain 9 2 2
MIRT624968 ZNF665 zinc finger protein 665 2 4
MIRT625479 SMAD9 SMAD family member 9 2 2
MIRT626594 ACAA2 acetyl-CoA acyltransferase 2 2 4
MIRT626708 TRIM65 tripartite motif containing 65 2 2
MIRT626975 LINC00598 long intergenic non-protein coding RNA 598 2 2
MIRT627489 STRIP2 striatin interacting protein 2 2 2
MIRT628505 ZNF878 zinc finger protein 878 2 2
MIRT628533 ZNF701 zinc finger protein 701 2 2
MIRT628591 TMEM251 transmembrane protein 251 2 2
MIRT628818 SLC25A34 solute carrier family 25 member 34 2 2
MIRT628896 IGSF6 immunoglobulin superfamily member 6 2 2
MIRT628958 UBE2D4 ubiquitin conjugating enzyme E2 D4 (putative) 2 2
MIRT629005 OSBPL10 oxysterol binding protein like 10 2 2
MIRT629059 KIF1C kinesin family member 1C 2 2
MIRT629192 PAPOLA poly(A) polymerase alpha 2 2
MIRT629346 TMPRSS11BNL TMPRSS11B N-terminal like, pseudogene 2 2
MIRT629447 WIZ widely interspaced zinc finger motifs 2 2
MIRT629696 XKR4 XK related 4 2 2
MIRT629737 SCD5 stearoyl-CoA desaturase 5 2 2
MIRT629896 SPATA5 spermatogenesis associated 5 2 2
MIRT629953 GLP2R glucagon like peptide 2 receptor 2 2
MIRT630023 MTL5 testis expressed metallothionein like protein 2 2
MIRT630181 TLN1 talin 1 2 2
MIRT630325 PAQR5 progestin and adipoQ receptor family member 5 2 2
MIRT630389 MYH9 myosin heavy chain 9 2 4
MIRT630695 EXTL3 exostosin like glycosyltransferase 3 2 2
MIRT631054 LINC00346 long intergenic non-protein coding RNA 346 2 2
MIRT631130 SYNJ2 synaptojanin 2 2 2
MIRT631374 COL4A3BP collagen type IV alpha 3 binding protein 2 2
MIRT631557 TRAF3IP2 TRAF3 interacting protein 2 2 2
MIRT631615 PCDHB11 protocadherin beta 11 2 2
MIRT631935 CDKAL1 CDK5 regulatory subunit associated protein 1 like 1 2 4
MIRT632109 SSR1 signal sequence receptor subunit 1 2 2
MIRT632168 CCL22 C-C motif chemokine ligand 22 2 2
MIRT632445 SGTB small glutamine rich tetratricopeptide repeat containing beta 2 2
MIRT632652 NAV1 neuron navigator 1 2 2
MIRT632688 MTMR10 myotubularin related protein 10 2 2
MIRT632828 IGF1 insulin like growth factor 1 2 2
MIRT632905 FRRS1 ferric chelate reductase 1 2 2
MIRT633027 DNAL1 dynein axonemal light chain 1 2 2
MIRT633379 FBXW8 F-box and WD repeat domain containing 8 2 2
MIRT633440 KLLN killin, p53-regulated DNA replication inhibitor 2 2
MIRT633726 BPNT1 3'(2'), 5'-bisphosphate nucleotidase 1 2 2
MIRT633832 WHAMM WAS protein homolog associated with actin, golgi membranes and microtubules 2 2
MIRT633862 ATP6V1A ATPase H+ transporting V1 subunit A 2 2
MIRT634042 NUP155 nucleoporin 155 2 2
MIRT634266 TIAL1 TIA1 cytotoxic granule associated RNA binding protein like 1 2 2
MIRT634374 RAP2B RAP2B, member of RAS oncogene family 2 2
MIRT634439 PDE7A phosphodiesterase 7A 2 2
MIRT634573 LRIG2 leucine rich repeats and immunoglobulin like domains 2 2 2
MIRT634620 TOR1AIP2 torsin 1A interacting protein 2 2 2
MIRT634693 DSEL dermatan sulfate epimerase-like 2 2
MIRT634768 CD3D CD3d molecule 2 2
MIRT635024 WWTR1 WW domain containing transcription regulator 1 2 2
MIRT635384 NHLRC2 NHL repeat containing 2 2 2
MIRT635577 TTC9C tetratricopeptide repeat domain 9C 2 2
MIRT635793 DNAJC10 DnaJ heat shock protein family (Hsp40) member C10 2 2
MIRT635837 ZNF264 zinc finger protein 264 2 2
MIRT636043 ZSCAN29 zinc finger and SCAN domain containing 29 2 4
MIRT636070 ZNF280C zinc finger protein 280C 2 2
MIRT636697 ARSK arylsulfatase family member K 2 2
MIRT637438 ZNF324B zinc finger protein 324B 2 2
MIRT637582 PLD6 phospholipase D family member 6 2 2
MIRT637672 PPM1D protein phosphatase, Mg2+/Mn2+ dependent 1D 2 2
MIRT637887 SLC19A3 solute carrier family 19 member 3 2 4
MIRT638353 RBMS2 RNA binding motif single stranded interacting protein 2 2 4
MIRT638597 HINT1 histidine triad nucleotide binding protein 1 2 2
MIRT638821 CRTAP cartilage associated protein 2 2
MIRT638871 CEP97 centrosomal protein 97 2 4
MIRT639660 PPEF2 protein phosphatase with EF-hand domain 2 2 4
MIRT640200 TIMM50 translocase of inner mitochondrial membrane 50 2 2
MIRT641592 TNS4 tensin 4 2 2
MIRT644993 POLR2J3 RNA polymerase II subunit J3 2 2
MIRT645059 UQCRQ ubiquinol-cytochrome c reductase complex III subunit VII 2 2
MIRT646948 UPK3BL uroplakin 3B like 1 2 2
MIRT647306 RPH3AL rabphilin 3A like (without C2 domains) 2 2
MIRT648300 SNRPD1 small nuclear ribonucleoprotein D1 polypeptide 2 4
MIRT649043 SLC1A2 solute carrier family 1 member 2 2 2
MIRT649884 SLFN12L schlafen family member 12 like 2 2
MIRT650196 DOCK7 dedicator of cytokinesis 7 2 2
MIRT654789 PRICKLE1 prickle planar cell polarity protein 1 2 2
MIRT655667 NUP43 nucleoporin 43 2 2
MIRT655925 NDUFA4P1 NDUFA4, mitochondrial complex associated pseudogene 1 2 2
MIRT656433 MARCH6 membrane associated ring-CH-type finger 6 2 2
MIRT657713 GPC4 glypican 4 2 2
MIRT659302 CSTF1 cleavage stimulation factor subunit 1 2 2
MIRT659844 CAPZB capping actin protein of muscle Z-line beta subunit 2 2
MIRT660660 ANKFY1 ankyrin repeat and FYVE domain containing 1 2 2
MIRT661308 CPM carboxypeptidase M 2 2
MIRT661473 CHMP1B charged multivesicular body protein 1B 2 2
MIRT661906 EBNA1BP2 EBNA1 binding protein 2 2 2
MIRT662064 ZNF284 zinc finger protein 284 2 2
MIRT662491 ANGPT4 angiopoietin 4 2 2
MIRT662657 LRRC47 leucine rich repeat containing 47 2 2
MIRT662804 MSRB2 methionine sulfoxide reductase B2 2 2
MIRT663164 FGFR1OP FGFR1 oncogene partner 2 2
MIRT663376 ZNF770 zinc finger protein 770 2 4
MIRT663418 ZNF607 zinc finger protein 607 2 2
MIRT663990 WDR75 WD repeat domain 75 2 2
MIRT664157 APOBEC3F apolipoprotein B mRNA editing enzyme catalytic subunit 3F 2 4
MIRT664489 POLR3K RNA polymerase III subunit K 2 2
MIRT665058 CCDC77 coiled-coil domain containing 77 2 2
MIRT665080 CRIPT CXXC repeat containing interactor of PDZ3 domain 2 2
MIRT665420 WDR55 WD repeat domain 55 2 2
MIRT665716 TMTC1 transmembrane and tetratricopeptide repeat containing 1 2 2
MIRT665923 TBC1D19 TBC1 domain family member 19 2 4
MIRT666239 SLC38A7 solute carrier family 38 member 7 2 4
MIRT666840 PPTC7 PTC7 protein phosphatase homolog 2 2
MIRT667378 MOB1B MOB kinase activator 1B 2 2
MIRT667573 LONRF2 LON peptidase N-terminal domain and ring finger 2 2 2
MIRT667894 ING1 inhibitor of growth family member 1 2 2
MIRT667977 HECTD3 HECT domain E3 ubiquitin protein ligase 3 2 2
MIRT668197 GCNT4 glucosaminyl (N-acetyl) transferase 4, core 2 2 2
MIRT668279 FOSL2 FOS like 2, AP-1 transcription factor subunit 2 2
MIRT668386 FAT3 FAT atypical cadherin 3 2 2
MIRT668444 FAM208A family with sequence similarity 208 member A 2 2
MIRT668998 CHORDC1 cysteine and histidine rich domain containing 1 2 2
MIRT669180 CCNF cyclin F 2 2
MIRT669444 ATL3 atlastin GTPase 3 2 2
MIRT669661 ACAP2 ArfGAP with coiled-coil, ankyrin repeat and PH domains 2 2 2
MIRT669890 KIAA0754 KIAA0754 2 4
MIRT669973 SSR3 signal sequence receptor subunit 3 2 2
MIRT670153 SLC29A4 solute carrier family 29 member 4 2 2
MIRT670240 TRIM13 tripartite motif containing 13 2 2
MIRT670274 CBY3 chibby family member 3 2 2
MIRT670358 ULBP3 UL16 binding protein 3 2 4
MIRT670627 BVES blood vessel epicardial substance 2 2
MIRT670731 HOOK3 hook microtubule tethering protein 3 2 2
MIRT670770 TRIM66 tripartite motif containing 66 2 2
MIRT670913 DESI1 desumoylating isopeptidase 1 2 2
MIRT671216 CLSTN1 calsyntenin 1 2 2
MIRT671398 ERCC6L2 ERCC excision repair 6 like 2 2 2
MIRT671427 TOX4 TOX high mobility group box family member 4 2 2
MIRT671654 TRUB2 TruB pseudouridine synthase family member 2 2 4
MIRT671702 PMPCA peptidase, mitochondrial processing alpha subunit 2 2
MIRT672136 PLEKHH1 pleckstrin homology, MyTH4 and FERM domain containing H1 2 2
MIRT672395 SLC10A6 solute carrier family 10 member 6 2 2
MIRT672508 GGCX gamma-glutamyl carboxylase 2 2
MIRT672572 RNF24 ring finger protein 24 2 2
MIRT672789 PPM1L protein phosphatase, Mg2+/Mn2+ dependent 1L 2 2
MIRT673019 RBBP4 RB binding protein 4, chromatin remodeling factor 2 2
MIRT673190 C10orf76 chromosome 10 open reading frame 76 2 2
MIRT673372 ZNF124 zinc finger protein 124 2 2
MIRT673495 MCF2L2 MCF.2 cell line derived transforming sequence-like 2 2 6
MIRT673852 CAPN7 calpain 7 2 2
MIRT673929 ZNF500 zinc finger protein 500 2 2
MIRT673986 MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 2 2
MIRT674076 PLEKHA1 pleckstrin homology domain containing A1 2 2
MIRT674123 RPL7L1 ribosomal protein L7 like 1 2 2
MIRT674297 THAP5 THAP domain containing 5 2 2
MIRT674370 POLR3D RNA polymerase III subunit D 2 2
MIRT674641 NKRF NFKB repressing factor 2 2
MIRT674665 PLCE1 phospholipase C epsilon 1 2 2
MIRT674725 ZNF451 zinc finger protein 451 2 4
MIRT674779 NPR1 natriuretic peptide receptor 1 2 2
MIRT674889 RASSF9 Ras association domain family member 9 2 2
MIRT675017 SNX1 sorting nexin 1 2 2
MIRT675341 KLHL26 kelch like family member 26 2 2
MIRT675416 CLEC7A C-type lectin domain containing 7A 2 2
MIRT675497 HSD17B12 hydroxysteroid 17-beta dehydrogenase 12 2 2
MIRT675615 EHD2 EH domain containing 2 2 2
MIRT675735 AHR aryl hydrocarbon receptor 2 2
MIRT675857 ATP1B4 ATPase Na+/K+ transporting family member beta 4 2 2
MIRT675990 CRKL CRK like proto-oncogene, adaptor protein 2 2
MIRT676213 TMEM91 transmembrane protein 91 2 2
MIRT676406 MRO maestro 2 2
MIRT677299 CPSF2 cleavage and polyadenylation specific factor 2 2 2
MIRT677387 PCNP PEST proteolytic signal containing nuclear protein 2 2
MIRT677859 ABI2 abl interactor 2 2 2
MIRT677965 ITGB3 integrin subunit beta 3 2 2
MIRT678175 CRCP CGRP receptor component 2 2
MIRT678273 PTRH2 peptidyl-tRNA hydrolase 2 2 2
MIRT678665 SCUBE3 signal peptide, CUB domain and EGF like domain containing 3 2 2
MIRT679003 TTC39B tetratricopeptide repeat domain 39B 2 2
MIRT679053 RMDN1 regulator of microtubule dynamics 1 2 2
MIRT679461 RHOF ras homolog family member F, filopodia associated 2 2
MIRT679513 RAB36 RAB36, member RAS oncogene family 2 2
MIRT679914 ZKSCAN3 zinc finger with KRAB and SCAN domains 3 2 2
MIRT680029 OSBPL2 oxysterol binding protein like 2 2 4
MIRT680245 NDUFA7 NADH:ubiquinone oxidoreductase subunit A7 2 2
MIRT680279 AKIP1 A-kinase interacting protein 1 2 2
MIRT680499 PRIM2 DNA primase subunit 2 2 2
MIRT680586 ZNF573 zinc finger protein 573 2 2
MIRT680629 KIAA1456 KIAA1456 2 2
MIRT680819 ARL8B ADP ribosylation factor like GTPase 8B 2 2
MIRT680998 AAED1 AhpC/TSA antioxidant enzyme domain containing 1 2 2
MIRT681122 INTS7 integrator complex subunit 7 2 2
MIRT681161 IBA57 IBA57 homolog, iron-sulfur cluster assembly 2 2
MIRT681221 DUSP19 dual specificity phosphatase 19 2 2
MIRT681304 IKZF3 IKAROS family zinc finger 3 2 2
MIRT681341 BRI3BP BRI3 binding protein 2 2
MIRT681608 F2RL2 coagulation factor II thrombin receptor like 2 2 2
MIRT681779 EIF4A3 eukaryotic translation initiation factor 4A3 2 2
MIRT681892 SLC11A2 solute carrier family 11 member 2 2 2
MIRT682084 ITGA3 integrin subunit alpha 3 2 4
MIRT682139 SMS spermine synthase 2 2
MIRT682217 SAR1A secretion associated Ras related GTPase 1A 2 2
MIRT682367 PHACTR4 phosphatase and actin regulator 4 2 2
MIRT682535 EXOSC2 exosome component 2 2 2
MIRT682618 COX6B1 cytochrome c oxidase subunit 6B1 2 2
MIRT683643 ZNF695 zinc finger protein 695 2 2
MIRT684008 FOLR1 folate receptor 1 2 2
MIRT684442 MFSD4 major facilitator superfamily domain containing 4A 2 2
MIRT684855 ZNF749 zinc finger protein 749 2 2
MIRT684956 MINOS1 mitochondrial inner membrane organizing system 1 2 2
MIRT685044 GEMIN4 gem nuclear organelle associated protein 4 2 2
MIRT685095 DTD2 D-tyrosyl-tRNA deacylase 2 (putative) 2 2
MIRT685382 TNFRSF13C TNF receptor superfamily member 13C 2 2
MIRT685456 CACNG8 calcium voltage-gated channel auxiliary subunit gamma 8 2 2
MIRT685810 SLC27A1 solute carrier family 27 member 1 2 2
MIRT685913 MOCS3 molybdenum cofactor synthesis 3 2 2
MIRT686665 TMEM120B transmembrane protein 120B 2 2
MIRT686955 SFT2D2 SFT2 domain containing 2 2 2
MIRT687118 QPCTL glutaminyl-peptide cyclotransferase like 2 2
MIRT687739 KIAA1328 KIAA1328 2 2
MIRT688063 GLUL glutamate-ammonia ligase 2 2
MIRT688191 FNIP1 folliculin interacting protein 1 2 2
MIRT688769 CDH7 cadherin 7 2 2
MIRT688979 ATP6AP1 ATPase H+ transporting accessory protein 1 2 2
MIRT689572 NUDT7 nudix hydrolase 7 2 2
MIRT689683 TMPRSS12 transmembrane protease, serine 12 2 2
MIRT689930 MANSC1 MANSC domain containing 1 2 2
MIRT690089 PNMA2 paraneoplastic Ma antigen 2 2 2
MIRT690190 C5orf45 MRN complex interacting protein 2 2
MIRT690246 CAMLG calcium modulating ligand 2 2
MIRT690411 FAM71F2 family with sequence similarity 71 member F2 2 2
MIRT690840 DSN1 DSN1 homolog, MIS12 kinetochore complex component 2 2
MIRT690889 FUT2 fucosyltransferase 2 2 2
MIRT691107 ADIPOQ adiponectin, C1Q and collagen domain containing 2 2
MIRT691229 DFNB59 pejvakin 2 2
MIRT691300 ZNF681 zinc finger protein 681 2 2
MIRT691366 GP5 glycoprotein V platelet 2 2
MIRT691797 WARS tryptophanyl-tRNA synthetase 2 2
MIRT692142 CEP104 centrosomal protein 104 2 2
MIRT692572 NCMAP non-compact myelin associated protein 2 2
MIRT692649 ZMYM1 zinc finger MYM-type containing 1 2 2
MIRT692744 NDUFS5 NADH:ubiquinone oxidoreductase subunit S5 2 2
MIRT693092 SCNM1 sodium channel modifier 1 2 2
MIRT693296 SYTL3 synaptotagmin like 3 2 2
MIRT693392 ZNF460 zinc finger protein 460 2 2
MIRT693530 ZNF708 zinc finger protein 708 2 2
MIRT693562 PIGR polymeric immunoglobulin receptor 2 2
MIRT694492 AGBL5 ATP/GTP binding protein like 5 2 2
MIRT694722 LLGL1 LLGL1, scribble cell polarity complex component 2 2
MIRT694866 ZNF417 zinc finger protein 417 2 2
MIRT695070 ZNF17 zinc finger protein 17 2 2
MIRT695451 COX18 COX18, cytochrome c oxidase assembly factor 2 2
MIRT695724 ZNF117 zinc finger protein 117 2 2
MIRT695898 MED16 mediator complex subunit 16 2 2
MIRT696244 UGGT1 UDP-glucose glycoprotein glucosyltransferase 1 2 2
MIRT696259 TACO1 translational activator of cytochrome c oxidase I 2 2
MIRT696512 C3 complement C3 2 2
MIRT696560 TTC21B tetratricopeptide repeat domain 21B 2 2
MIRT696643 AGXT2 alanine--glyoxylate aminotransferase 2 2 2
MIRT696791 DHODH dihydroorotate dehydrogenase (quinone) 2 2
MIRT696819 PLLP plasmolipin 2 2
MIRT697088 GPKOW G-patch domain and KOW motifs 2 2
MIRT697153 INMT indolethylamine N-methyltransferase 2 2
MIRT697202 ZYG11A zyg-11 family member A, cell cycle regulator 2 2
MIRT697322 ZNF641 zinc finger protein 641 2 2
MIRT697578 YME1L1 YME1 like 1 ATPase 2 2
MIRT697619 WSB1 WD repeat and SOCS box containing 1 2 2
MIRT698619 TES testin LIM domain protein 2 2
MIRT698804 STK38 serine/threonine kinase 38 2 2
MIRT698949 SPAST spastin 2 2
MIRT699083 SNRPD3 small nuclear ribonucleoprotein D3 polypeptide 2 2
MIRT699430 SLC1A5 solute carrier family 1 member 5 2 2
MIRT699550 SIT1 signaling threshold regulating transmembrane adaptor 1 2 2
MIRT700324 RAB4A RAB4A, member RAS oncogene family 2 2
MIRT700360 RAB33B RAB33B, member RAS oncogene family 2 2
MIRT700462 PURB purine rich element binding protein B 2 2
MIRT701677 MYADM myeloid associated differentiation marker 2 2
MIRT701757 MSL2 MSL complex subunit 2 2 2
MIRT701977 MIER3 MIER family member 3 2 2
MIRT703178 GPBP1 GC-rich promoter binding protein 1 2 2
MIRT703203 GOLGA3 golgin A3 2 2
MIRT703359 GAPVD1 GTPase activating protein and VPS9 domains 1 2 2
MIRT703425 FYTTD1 forty-two-three domain containing 1 2 2
MIRT703484 FNDC3B fibronectin type III domain containing 3B 2 2
MIRT703590 FBXO45 F-box protein 45 2 2
MIRT703806 EVI5 ecotropic viral integration site 5 2 2
MIRT703915 EPG5 ectopic P-granules autophagy protein 5 homolog 2 2
MIRT704234 DHDDS dehydrodolichyl diphosphate synthase subunit 2 2
MIRT704646 CLCC1 chloride channel CLIC like 1 2 2
MIRT705151 C11orf58 chromosome 11 open reading frame 58 2 2
MIRT705480 ASXL2 additional sex combs like 2, transcriptional regulator 2 2
MIRT705530 ARL10 ADP ribosylation factor like GTPase 10 2 2
MIRT705661 ANKRD40 ankyrin repeat domain 40 2 2
MIRT706144 ZNF674 zinc finger protein 674 2 2
MIRT706473 SNX27 sorting nexin family member 27 2 2
MIRT708254 PGPEP1 pyroglutamyl-peptidase I 2 2
MIRT708838 SCAND3 zinc finger BED-type containing 9 1 1
MIRT710437 BTNL3 butyrophilin like 3 2 2
MIRT711325 DPYSL5 dihydropyrimidinase like 5 2 2
MIRT716151 RBM48 RNA binding motif protein 48 2 2
MIRT717402 ZCCHC24 zinc finger CCHC-type containing 24 2 2
MIRT720866 ADCY5 adenylate cyclase 5 2 2
MIRT722226 ZNF503 zinc finger protein 503 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-1273h-5p Paclitaxel 36314 NSC125973 approved sensitive High Ovarian Cancer cell line (SKOV3)
hsa-miR-1273h-5p Tripterygium wilfordii Hook F resistant tissue
hsa-miR-1273h-5p Cisplatin 5460033 NSC119875 approved sensitive cell line (MGC-803)

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