miRTarBase - #MIRT452980


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pre-miRNA Information
pre-miRNA hsa-mir-106a   
Genomic Coordinates chrX: 134170198 - 134170278
Description Homo sapiens miR-106a stem-loop
Comment This miRNA was not cloned in reference .
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-106a-3p
Sequence 50| CUGCAAUGUAAGCACUUCUUAC |71
Evidence Experimental
Experiments Cloned
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs927823355 6 dbSNP
rs1448271699 8 dbSNP
rs1477844174 12 dbSNP
rs1358970494 18 dbSNP
rs781747706 21 dbSNP
Putative Targets

miRNA Expression profile
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Biomarker Information
Biomarker ID Name Type Discovered From Mode Level Source Testing Methods
BN3X2A miR-106a Predictive Biomarker (PRD) Clinical/Experimental Data Expression Decrease Tumor tissue Quantitative real-time PCR
Gene Information
Gene Symbol CABP4   
Synonyms CRSD, CSNB2B
Description calcium binding protein 4
Transcript NM_145200   
Expression
Putative miRNA Targets on CABP4
3'UTR of CABP4
(miRNA target sites are highlighted)		 
>CABP4|NM_145200|3'UTR
   1 GGCTCCAGGAGGGAATATCTGTTGCCCCTGCGGCCCCAGACACCAGCCAGACCCAGGCTGCAGGCCTCCCCCAGGAGCCT
  81 CCAGGATGGAGATGGAGACCCAGCAGCCCCCAGACTACTTCTATCCCTGAAAACACCTGGCCTCAATGTTGGCTTGTTAT
 161 GTTACCTGCCCACCCTCATCCTTACCTCCTCCTACTCAAGCTGCCTGGAGAAGACCTGCTCTCAGCTGCCCACCGTTCCT
 241 CAGTGTGAGCAAGATTTGGGTCTCTCCAGACCTCTGGGAGGTAGGGAGTTCCCTGGCACTGGCAGCATTCAGTGGGGACC
 321 CCCCAGTGGCATGATGAATGGAGAGGATGGCTGGACCCCTTCCACTACTTATGTTTATAATTTTTTTTTTTTTTAATGAA
 401 CTTGAGCCGGGTGCAGTGGCTCACACCTGTAAGCCCAGCTGTCAGGGGGCAGAAGCGGGAGGATAGCTTGAGCCCAGGAG
 481 TGCAAGACCTGCCTGGGCAATATACTGAGACCCCATTCTCCACAAAAAGGAAAAATAAAAGACAAAAAAACAAACAAAAA
 561 ACCAAAAAACCCAAGTGTAAAAAAAGTGAGCTTGAAAGAAAGAAAGGGATGGCTCCATGTATCAAAGACAAAGAAATCAA
 641 AGCTGGGGTTGTAAGAGGGAGCTGACGCTGTGGGGGTTTCAGATCTGGATGGAGGCTTGGCCGCCTGGACTCCTACAACC
 721 ATGAGTGACAGAAGAACCATATGAGTCTGGGGAGCAAGAAACAAACCCCCCGGATATATTCCAGGGTCTCCAAAGGCTAA
 801 GATATTAATCTGTCTGCACTGACCAGTCATAGAAAGTGGCAAGGATACAGATGTTCAGGGCCCAGAGTGGAAACAGCTGC
 881 CCTAAAGAGCCTGGAACTCCAGGGCCTGCCCTTCAAGCAGGCGTGTAGTCTCTCTCCAGGGTGTGAAAAACTGGAAAAAA
 961 ACCCTGCCGCTCCCAAAGGGGAACTTGTGATAAAAATTACAGATTATTGGGCTGGGAGTGGTGGCTCACGCCTGTAATCC
1041 CAGCACTTTGGGAGGCTGAGGCGGGTGAATTACCTGAGGTCAGGAGTTTGAGGCCAGCCTGACCAACATGGTGAAACCCC
1121 ATCTCTACTAAAAATACAAAAATTAACTGGGCGAGGTAGCATGCACCTGTAATCTCAGCTACTCGGAGGTTGAGGCAGGA
1201 GAATCGCTTGAGCCCGGGAGGTGGAGCTGCAGTGAGCTGAGATCACACCATTGCACCCCAGCCTGAGCAACAGATCGAGA
1281 CTCCGTCTCAAAAACAAAACAAAAAAACCATACTGATTATAAAAGTAAAGAAACCACCATGAAGGAGACGAGACAGAGAC
1361 AAAAACAAGAGGACTGGCATCTCAGTGTACATAATACAGCCGCCTAAGAGACCACAAGATACATGCAAATAAAAGACGGC
1441 TAAAAGGGGAAGAGAGATCAACATGCAGTAACAGGATAGTATGAAGAGAGAACCGGAAGATTTAAAAAGTAACCCAACAG
1521 GCCAGGCGCATGGCTCATGCCTGGAATCCCAGCACTTTGGGAGGCCAAGGTGGGTGGGTTGCTTGAGCTCAGGAATTCGA
1601 GACCAGCCTGGGCAACATGGTGAAACCCTGTCTCTACTAAAAATACAAAAATTAGCCAGGCGTGGTGGTGCTTGCATCTG
1681 TGGTCCCAGGTATTCTACAGGCTGAGGTGGGAGGATCACTTGAGCCCAGGAGGCAGAGGTTGCAGTGAGTCGAGATCGCA
1761 CCACTGCACTCCAGCGTGGGTAACAGAGTGAGAATCCGTCAAAAAGAAAAAAACAAACCATGGCTTCTGTTAAAAAAATA
1841 AAGTATATTTTATATATACACACACACACACACACACACACACAGCCATTGGAATGAAAAAATAATGGATAAGCTAAACA
1921 GCAGATTAAACACAATTTAAAGATTAATGAACTGGAAGCTATATCTAAGAAATCACTTATAATGTAACACTGAGAGACAA
2001 AAGGATGGAAAATATTACAGGGTAGTTAAAAGTCACTGGAAGGCTGGGTGTGGTGGCTCACGCCTGTAATCCCAGCACTT
2081 TGGGAGGCTGAGACGGGCGGGTCACAGGGTCAGGAGATCGAGACCATCCTGGCTAACACAGTGAAACCCCATCTCTACTA
2161 AAAATACAAAAAAAAATTAGCTGGGCGTGGTGGCGGGCGCCTGTAGTCCCAGCTACTAGGGAGGCTGAGGCAAGAGAATG
2241 GCGTGAACCCAGGAGGCGGAGCTTGCAGTGAGCCGAGATTGCACCACTGCACTCCAGCCTGGGCTACAGAGCGAGACTCC
2321 GTCTCGGAAAAAAAAAAAAAAAAAGGTCACTGGAAGACTGGGTGTGGTGGCTTATGCCTGTAATCCCAGCATTTTGGGAG
2401 GCTAAGGCAGGAGGATCACTTGAGGCCAGGAGTTTGAGACCAGCCTAACAGCAAGACCCTGCCTCTTAAAAAAAATAATA
2481 AAAAAATAAGCTGGGTGTAGTGGCTCATGCTTGTAGTTCCAGCTATTCAGGAGGCTGAGGTGAGAGGATCATTTGAGCCC
2561 AGGAGTTGGAGGCTGCAGTGATCGTGCCACTGCACTCCAGCCTTGGTGACAGAGCAAGAGACCCTGTCTCAAAGAAAAAG
2641 ACAGATAAGTCCTTGGGAGTCTCAGACGGAGGACATACATAGAGAATGAACAAGAAGCAATAACCAAAGAGATAATGGCT
2721 GAAAATTTTCCATAAAGACTTCCACAGACTTCAACTCCCCAGATTGAAGGAACAAACTGAAGTCAGAGTAGGGTAAATAA
2801 AAATAAATATATATCTGGATATATCCCATTGAAACCACAGAATATAAAAAGCAAATCTTATAAATAACTGGAGAGAAAAG
2881 TCAGATTCACGGTGTTCTGTCAAAGTGTTCATGTAGACTAAGGGTGGGGAAACTTTCTGTAAAGGGCTGGAGAATAATTA
2961 TTTTCAGCTTTGAGGCTTTGGTCTCTGTTGCAGCTGCTCACGCAACTCTGCTGTTGAAGTTTGTAGTGCAAAGTCAAGTC
3041 AACAAATGAGTGTGGCTATATCAGAAATTTTAATAAATAACAGTAAAACTTCATTTATTGACATGGAAATTTGAAAAAAA
3121 AAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' caUUCUUCACGAAU---GUAACGUc 5'
            :||  | | | |   ||||||| 
Target 5' gtGAGCTGAGATCACACCATTGCAc 3'
 1232 - 1256 144.00 -7.82
2 
miRNA  3' cauuCUUCA--CGAAUGUAACGUc 5'
              | |||  ||  | |||||| 
Target 5' gcttGCAGTGAGCCGAGATTGCAc 3'
 2261 - 2284 124.00 -8.20
3 
miRNA  3' cauuCUUCAC--GAAU-GUAACGUc 5'
              | ||||  | |: || |||| 
Target 5' ggctGCAGTGATCGTGCCACTGCAc 3'
 2571 - 2595 120.00 -11.40
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
305662 27 ClinVar
879587 63 ClinVar
305663 120 ClinVar
305664 121 ClinVar
305665 263 ClinVar
879938 296 ClinVar
305666 325 ClinVar
305667 381 ClinVar
879939 395 ClinVar
879940 409 ClinVar
305668 670 ClinVar
305669 682 ClinVar
305670 684 ClinVar
877142 703 ClinVar
305671 877 ClinVar
305672 964 ClinVar
305673 1041 ClinVar
877143 1064 ClinVar
305674 1118 ClinVar
877144 1159 ClinVar
878175 1191 ClinVar
305675 1224 ClinVar
305676 1286 ClinVar
305677 1292 ClinVar
305678 1391 ClinVar
878176 1393 ClinVar
878177 1403 ClinVar
878178 1414 ClinVar
305679 1436 ClinVar
879630 1511 ClinVar
305680 1528 ClinVar
879631 1637 ClinVar
879632 1663 ClinVar
305681 1698 ClinVar
879633 1759 ClinVar
305682 1807 ClinVar
305683 1828 ClinVar
305684 1851 ClinVar
305685 1851 ClinVar
305686 1854 ClinVar
305687 1856 ClinVar
305688 1856 ClinVar
305689 1856 ClinVar
305690 1858 ClinVar
305691 1858 ClinVar
305692 1858 ClinVar
305693 1858 ClinVar
305694 1858 ClinVar
305695 1858 ClinVar
305696 1858 ClinVar
305697 1858 ClinVar
305698 1860 ClinVar
305699 1860 ClinVar
879996 1874 ClinVar
305700 1878 ClinVar
305701 1934 ClinVar
305702 1940 ClinVar
879997 1958 ClinVar
879998 2001 ClinVar
879999 2005 ClinVar
877199 2062 ClinVar
305703 2066 ClinVar
305704 2090 ClinVar
305705 2099 ClinVar
305706 2168 ClinVar
877200 2187 ClinVar
305707 2188 ClinVar
305708 2196 ClinVar
305709 2313 ClinVar
305710 2326 ClinVar
305711 2328 ClinVar
305712 2332 ClinVar
878240 2358 ClinVar
305713 2439 ClinVar
305714 2584 ClinVar
305715 2669 ClinVar
305716 2680 ClinVar
305717 2710 ClinVar
878241 2717 ClinVar
879691 2837 ClinVar
879692 2861 ClinVar
879693 2887 ClinVar
879694 2897 ClinVar
879695 2906 ClinVar
879696 2959 ClinVar
305718 3044 ClinVar
COSN30144284 12 COSMIC
COSN30181513 14 COSMIC
COSN30468557 14 COSMIC
COSN31552930 20 COSMIC
COSN30191461 32 COSMIC
COSN26968906 33 COSMIC
COSN30127146 60 COSMIC
COSN30465366 85 COSMIC
COSN31488333 86 COSMIC
COSN31488570 92 COSMIC
COSN31543163 104 COSMIC
COSN30151751 110 COSMIC
COSN30190431 118 COSMIC
COSN507354 119 COSMIC
COSN31591465 210 COSMIC
COSN20508842 250 COSMIC
COSN5917089 478 COSMIC
COSN22828700 604 COSMIC
COSN26753350 689 COSMIC
COSN21789045 782 COSMIC
COSN15082637 857 COSMIC
COSN15122750 858 COSMIC
COSN27609208 962 COSMIC
COSN24428689 1296 COSMIC
COSN22739937 1361 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs569872151 5 dbSNP
rs898778158 5 dbSNP
rs748195294 6 dbSNP
rs749036787 7 dbSNP
rs931592206 10 dbSNP
rs758583912 13 dbSNP
rs777890480 20 dbSNP
rs887134726 26 dbSNP
rs747352890 27 dbSNP
rs1008239273 30 dbSNP
rs771250959 31 dbSNP
rs529589052 32 dbSNP
rs1019686545 33 dbSNP
rs1286938410 36 dbSNP
rs548141133 38 dbSNP
rs202212392 40 dbSNP
rs560082251 44 dbSNP
rs773852144 47 dbSNP
rs1440317899 49 dbSNP
rs899658098 63 dbSNP
rs1481119889 73 dbSNP
rs1207224203 81 dbSNP
rs1200358058 90 dbSNP
rs1456293091 93 dbSNP
rs996674799 119 dbSNP
rs1790736 120 dbSNP
rs372107215 121 dbSNP
rs1313826199 122 dbSNP
rs1032080797 129 dbSNP
rs570414838 148 dbSNP
rs1373661841 150 dbSNP
rs1332932149 152 dbSNP
rs1444061611 158 dbSNP
rs1400027868 161 dbSNP
rs1337734059 162 dbSNP
rs760779526 166 dbSNP
rs977366671 168 dbSNP
rs769163963 169 dbSNP
rs1021210075 171 dbSNP
rs1419723853 175 dbSNP
rs1265404246 176 dbSNP
rs537566910 186 dbSNP
rs1177038816 187 dbSNP
rs1439247033 189 dbSNP
rs1237358902 193 dbSNP
rs970600317 195 dbSNP
rs549538705 196 dbSNP
rs1031729385 207 dbSNP
rs1254144706 222 dbSNP
rs1198018314 226 dbSNP
rs1378144279 231 dbSNP
rs567943756 235 dbSNP
rs1317016447 236 dbSNP
rs1310722336 251 dbSNP
rs886048562 263 dbSNP
rs1375674961 270 dbSNP
rs772851120 282 dbSNP
rs1316250466 287 dbSNP
rs959705498 292 dbSNP
rs181113902 296 dbSNP
rs769973044 297 dbSNP
rs1400752403 298 dbSNP
rs1302798525 300 dbSNP
rs1454725603 308 dbSNP
rs992562538 313 dbSNP
rs1156868188 314 dbSNP
rs1419392913 314 dbSNP
rs1184017178 319 dbSNP
rs926587486 319 dbSNP
rs886048563 325 dbSNP
rs1253764465 331 dbSNP
rs143907498 348 dbSNP
rs973429498 357 dbSNP
rs948197685 367 dbSNP
rs1322174679 369 dbSNP
rs553822363 369 dbSNP
rs1169445927 381 dbSNP
rs1216209571 381 dbSNP
rs3835327 381 dbSNP
rs397744121 381 dbSNP
rs920111245 381 dbSNP
rs1312372561 387 dbSNP
rs931535237 388 dbSNP
rs1385748058 393 dbSNP
rs1047325440 395 dbSNP
rs1333400343 407 dbSNP
rs376738871 409 dbSNP
rs775755989 410 dbSNP
rs572401751 412 dbSNP
rs890625688 414 dbSNP
rs1366507080 416 dbSNP
rs944938776 419 dbSNP
rs1226929496 423 dbSNP
rs1265204938 425 dbSNP
rs148612796 428 dbSNP
rs1487688393 435 dbSNP
rs765865925 446 dbSNP
rs944066488 447 dbSNP
rs1353751299 449 dbSNP
rs1265284766 452 dbSNP
rs900793504 457 dbSNP
rs1320673422 458 dbSNP
rs1230417616 462 dbSNP
rs1276836025 465 dbSNP
rs1263920697 466 dbSNP
rs1041108595 468 dbSNP
rs368995514 474 dbSNP
rs1325537662 476 dbSNP
rs141182457 490 dbSNP
rs996462572 495 dbSNP
rs899960922 500 dbSNP
rs1292765443 511 dbSNP
rs1465923688 521 dbSNP
rs1210510864 530 dbSNP
rs866365965 531 dbSNP
rs1168484516 537 dbSNP
rs185956229 537 dbSNP
rs1032463264 544 dbSNP
rs1477416311 544 dbSNP
rs1200357135 548 dbSNP
rs1266194749 551 dbSNP
rs1449582587 551 dbSNP
rs879146930 554 dbSNP
rs1196796157 556 dbSNP
rs893518473 557 dbSNP
rs1256520001 558 dbSNP
rs1218573934 562 dbSNP
rs996894148 563 dbSNP
rs1021837690 564 dbSNP
rs1179715377 565 dbSNP
rs576577876 570 dbSNP
rs1231117103 579 dbSNP
rs1330789985 594 dbSNP
rs970566236 598 dbSNP
rs1449224731 607 dbSNP
rs981965286 610 dbSNP
rs1328974267 611 dbSNP
rs1472810116 616 dbSNP
rs999148826 619 dbSNP
rs1173862726 622 dbSNP
rs1031614278 630 dbSNP
rs1376528703 630 dbSNP
rs1178903154 632 dbSNP
rs973423917 634 dbSNP
rs763174697 636 dbSNP
rs1198400996 638 dbSNP
rs1366358298 642 dbSNP
rs1281319124 645 dbSNP
rs1199193274 652 dbSNP
rs1344436403 653 dbSNP
rs1280142798 663 dbSNP
rs1242603700 665 dbSNP
rs1374936119 667 dbSNP
rs886048564 670 dbSNP
rs992529853 676 dbSNP
rs920592912 678 dbSNP
rs543961015 682 dbSNP
rs146218513 684 dbSNP
rs1307992452 686 dbSNP
rs973196092 696 dbSNP
rs1412075901 700 dbSNP
rs1158667047 702 dbSNP
rs574323434 703 dbSNP
rs931528297 704 dbSNP
rs1178477526 708 dbSNP
rs1039213424 717 dbSNP
rs1239512128 721 dbSNP
rs1321414689 726 dbSNP
rs1186090062 730 dbSNP
rs900760872 742 dbSNP
rs1218845768 743 dbSNP
rs983421024 749 dbSNP
rs1261423516 758 dbSNP
rs1351864401 762 dbSNP
rs1285561785 763 dbSNP
rs1245588393 766 dbSNP
rs908838478 766 dbSNP
rs944033759 769 dbSNP
rs1445758993 771 dbSNP
rs768551163 772 dbSNP
rs1298352851 797 dbSNP
rs1401299151 802 dbSNP
rs1053423532 805 dbSNP
rs541706301 806 dbSNP
rs1157682690 808 dbSNP
rs1405554073 824 dbSNP
rs932714164 827 dbSNP
rs1009294284 836 dbSNP
rs1021105232 838 dbSNP
rs1251006534 841 dbSNP
rs1483222420 844 dbSNP
rs1161804290 847 dbSNP
rs79733334 849 dbSNP
rs1178799409 861 dbSNP
rs189731301 867 dbSNP
rs1253627122 871 dbSNP
rs1422928664 874 dbSNP
rs1196008973 876 dbSNP
rs11601325 877 dbSNP
rs1262478665 885 dbSNP
rs1386517161 890 dbSNP
rs577168001 895 dbSNP
rs144432491 898 dbSNP
rs1291816209 910 dbSNP
rs1053440744 915 dbSNP
rs895704948 918 dbSNP
rs543364807 923 dbSNP
rs1463844366 931 dbSNP
rs1301512786 932 dbSNP
rs1014185430 943 dbSNP
rs1022616472 944 dbSNP
rs1296989290 954 dbSNP
rs1436816148 955 dbSNP
rs985262502 962 dbSNP
rs76060170 964 dbSNP
rs531286246 965 dbSNP
rs1363053011 968 dbSNP
rs952991190 969 dbSNP
rs183419313 970 dbSNP
rs908722536 973 dbSNP
rs1489609850 978 dbSNP
rs1273822665 997 dbSNP
rs567905142 1006 dbSNP
rs1245192307 1012 dbSNP
rs1342856446 1013 dbSNP
rs965561444 1014 dbSNP
rs1258425824 1016 dbSNP
rs1200480939 1027 dbSNP
rs976989097 1030 dbSNP
rs1254067643 1031 dbSNP
rs911970986 1039 dbSNP
rs921234184 1040 dbSNP
rs186530202 1041 dbSNP
rs1272730821 1061 dbSNP
rs1043515263 1063 dbSNP
rs191030743 1064 dbSNP
rs911158058 1067 dbSNP
rs926096677 1081 dbSNP
rs922113011 1086 dbSNP
rs1400164098 1087 dbSNP
rs934751519 1091 dbSNP
rs1447054521 1104 dbSNP
rs1187454980 1110 dbSNP
rs565802060 1118 dbSNP
rs1430853408 1119 dbSNP
rs913507993 1127 dbSNP
rs750151193 1153 dbSNP
rs1238615561 1154 dbSNP
rs539741322 1159 dbSNP
rs1042087608 1171 dbSNP
rs1466889586 1184 dbSNP
rs1250677612 1185 dbSNP
rs183186439 1186 dbSNP
rs906278630 1187 dbSNP
rs1014152940 1189 dbSNP
rs1044363688 1190 dbSNP
rs7127024 1191 dbSNP
rs760609909 1202 dbSNP
rs1377151198 1203 dbSNP
rs537531908 1207 dbSNP
rs1434446461 1211 dbSNP
rs994551641 1212 dbSNP
rs766112266 1213 dbSNP
rs1303943645 1216 dbSNP
rs753487920 1217 dbSNP
rs1362535365 1218 dbSNP
rs754686225 1219 dbSNP
rs555941085 1224 dbSNP
rs994738513 1230 dbSNP
rs1382399898 1236 dbSNP
rs574182345 1238 dbSNP
rs1361901348 1240 dbSNP
rs11605548 1248 dbSNP
rs11601405 1254 dbSNP
rs1180338773 1258 dbSNP
rs1437608423 1266 dbSNP
rs965531117 1277 dbSNP
rs976957802 1278 dbSNP
rs373857371 1286 dbSNP
rs146149609 1292 dbSNP
rs1463310384 1296 dbSNP
rs1207523241 1301 dbSNP
rs1237427088 1304 dbSNP
rs553549818 1309 dbSNP
rs1018904896 1310 dbSNP
rs966067375 1313 dbSNP
rs974811513 1314 dbSNP
rs1189929826 1315 dbSNP
rs188509571 1319 dbSNP
rs922081352 1325 dbSNP
rs1419285044 1330 dbSNP
rs1425090335 1338 dbSNP
rs957752708 1341 dbSNP
rs978816890 1348 dbSNP
rs1434117353 1350 dbSNP
rs990362258 1351 dbSNP
rs1186670819 1359 dbSNP
rs1488336454 1361 dbSNP
rs913466747 1367 dbSNP
rs140203885 1373 dbSNP
rs1410005977 1378 dbSNP
rs925951731 1386 dbSNP
rs564944745 1391 dbSNP
rs77807407 1393 dbSNP
rs917076132 1400 dbSNP
rs1247440749 1402 dbSNP
rs949888937 1403 dbSNP
rs1320502483 1405 dbSNP
rs1044334296 1409 dbSNP
rs1291641601 1411 dbSNP
rs563724143 1414 dbSNP
rs781743235 1419 dbSNP
rs930563507 1420 dbSNP
rs547381974 1424 dbSNP
rs1048683968 1425 dbSNP
rs75914794 1436 dbSNP
rs1391680651 1438 dbSNP
rs1326861151 1449 dbSNP
rs543111733 1452 dbSNP
rs1004606330 1456 dbSNP
rs1415314102 1460 dbSNP
rs1227347630 1464 dbSNP
rs1268388559 1465 dbSNP
rs1478080721 1472 dbSNP
rs1448156154 1476 dbSNP
rs995072854 1477 dbSNP
rs1018678633 1481 dbSNP
rs1048928134 1483 dbSNP
rs1487711974 1491 dbSNP
rs1272900202 1494 dbSNP
rs1320593584 1495 dbSNP
rs561400843 1495 dbSNP
rs528993456 1496 dbSNP
rs1226775997 1500 dbSNP
rs1331954508 1506 dbSNP
rs1303691994 1511 dbSNP
rs547246461 1528 dbSNP
rs192714120 1538 dbSNP
rs1392054802 1541 dbSNP
rs1028521441 1546 dbSNP
rs1202002260 1556 dbSNP
rs1466116876 1575 dbSNP
rs533060454 1582 dbSNP
rs551692608 1589 dbSNP
rs1402368372 1590 dbSNP
rs570061594 1596 dbSNP
rs1165710954 1600 dbSNP
rs1018872418 1609 dbSNP
rs901871197 1612 dbSNP
rs1200587854 1629 dbSNP
rs1452131430 1630 dbSNP
rs954284054 1631 dbSNP
rs532435181 1637 dbSNP
rs555805758 1639 dbSNP
rs1459528696 1646 dbSNP
rs377617797 1647 dbSNP
rs1029020292 1652 dbSNP
rs957510022 1662 dbSNP
rs1257789507 1663 dbSNP
rs990721423 1666 dbSNP
rs567725957 1672 dbSNP
rs1472480583 1675 dbSNP
rs535143410 1676 dbSNP
rs1020454456 1677 dbSNP
rs1447231185 1681 dbSNP
rs956265114 1690 dbSNP
rs1378761960 1691 dbSNP
rs2514262 1698 dbSNP
rs183159788 1702 dbSNP
rs1409259629 1703 dbSNP
rs1402325314 1708 dbSNP
rs917378975 1710 dbSNP
rs1173796708 1718 dbSNP
rs1403670438 1720 dbSNP
rs949856463 1732 dbSNP
rs1164235903 1737 dbSNP
rs979898895 1741 dbSNP
rs927121590 1742 dbSNP
rs1181751121 1752 dbSNP
rs545370587 1759 dbSNP
rs1443480627 1774 dbSNP
rs930553882 1776 dbSNP
rs369603394 1777 dbSNP
rs1198800930 1779 dbSNP
rs1347504852 1782 dbSNP
rs938979619 1798 dbSNP
rs557279173 1799 dbSNP
rs1355627093 1806 dbSNP
rs200446327 1807 dbSNP
rs886048565 1807 dbSNP
rs916315686 1807 dbSNP
rs1279767073 1808 dbSNP
rs1335694869 1815 dbSNP
rs1049338014 1825 dbSNP
rs886048566 1828 dbSNP
rs1298434877 1835 dbSNP
rs80147679 1836 dbSNP
rs187653511 1837 dbSNP
rs75578020 1844 dbSNP
rs1352471286 1846 dbSNP
rs76463793 1848 dbSNP
rs77451107 1849 dbSNP
rs61889863 1851 dbSNP
rs748450531 1851 dbSNP
rs940589922 1851 dbSNP
rs1370691300 1854 dbSNP
rs759157298 1854 dbSNP
rs886048567 1854 dbSNP
rs1040250624 1856 dbSNP
rs533020503 1856 dbSNP
rs542972940 1856 dbSNP
rs886048568 1856 dbSNP
rs886048569 1857 dbSNP
rs11227798 1858 dbSNP
rs1215804303 1858 dbSNP
rs1269233722 1858 dbSNP
rs1359182878 1858 dbSNP
rs1436702780 1858 dbSNP
rs147580597 1858 dbSNP
rs1491046777 1858 dbSNP
rs373880828 1858 dbSNP
rs397749289 1858 dbSNP
rs886048570 1858 dbSNP
rs35146220 1859 dbSNP
rs886048571 1859 dbSNP
rs1324275484 1860 dbSNP
rs7936733 1860 dbSNP
rs901795950 1862 dbSNP
rs867214951 1874 dbSNP
rs1408286004 1875 dbSNP
rs1359572577 1877 dbSNP
rs886048572 1878 dbSNP
rs1028469561 1884 dbSNP
rs1225305183 1884 dbSNP
rs1273120095 1887 dbSNP
rs1479099319 1888 dbSNP
rs1482894425 1890 dbSNP
rs1183435195 1897 dbSNP
rs889967000 1898 dbSNP
rs1191513591 1912 dbSNP
rs1000441051 1919 dbSNP
rs1234800969 1923 dbSNP
rs1033705447 1927 dbSNP
rs886048573 1934 dbSNP
rs886048574 1940 dbSNP
rs548811817 1943 dbSNP
rs1181533164 1958 dbSNP
rs774271313 1960 dbSNP
rs748296888 1970 dbSNP
rs1271621959 1973 dbSNP
rs971432483 1981 dbSNP
rs1372681972 1982 dbSNP
rs980200763 1985 dbSNP
rs927120262 2001 dbSNP
rs570209950 2005 dbSNP
rs984706658 2013 dbSNP
rs907820710 2019 dbSNP
rs1020840434 2025 dbSNP
rs1428856335 2026 dbSNP
rs541154026 2031 dbSNP
rs1337131032 2044 dbSNP
rs1393491323 2045 dbSNP
rs981628410 2046 dbSNP
rs1039980270 2052 dbSNP
rs1445303897 2055 dbSNP
rs1178903617 2056 dbSNP
rs922941577 2060 dbSNP
rs1382811119 2062 dbSNP
rs1210199603 2063 dbSNP
rs1349673396 2064 dbSNP
rs886048575 2066 dbSNP
rs1247536474 2072 dbSNP
rs771896989 2078 dbSNP
rs1273099034 2079 dbSNP
rs1354902028 2079 dbSNP
rs886048576 2090 dbSNP
rs1196720324 2091 dbSNP
rs1275595520 2093 dbSNP
rs1373246715 2094 dbSNP
rs1441074258 2095 dbSNP
rs780002066 2096 dbSNP
rs886048577 2099 dbSNP
rs990449428 2100 dbSNP
rs916258667 2105 dbSNP
rs1453683057 2108 dbSNP
rs930360560 2109 dbSNP
rs749055593 2120 dbSNP
rs984575860 2121 dbSNP
rs1407143690 2134 dbSNP
rs907642129 2136 dbSNP
rs1000811992 2140 dbSNP
rs1054707443 2141 dbSNP
rs1486369135 2156 dbSNP
rs1186822812 2166 dbSNP
rs1040218186 2168 dbSNP
rs754783722 2168 dbSNP
rs886048578 2168 dbSNP
rs1488398608 2170 dbSNP
rs1262905778 2174 dbSNP
rs892018374 2175 dbSNP
rs541691229 2177 dbSNP
rs1168457171 2179 dbSNP
rs191420904 2187 dbSNP
rs886048579 2188 dbSNP
rs1412559915 2190 dbSNP
rs1292727722 2191 dbSNP
rs1001605836 2195 dbSNP
rs11822066 2196 dbSNP
rs778619168 2199 dbSNP
rs1290471863 2200 dbSNP
rs1406447390 2209 dbSNP
rs554195108 2218 dbSNP
rs1451375551 2238 dbSNP
rs1344315313 2241 dbSNP
rs1165430829 2243 dbSNP
rs985062656 2251 dbSNP
rs1415083068 2253 dbSNP
rs1186562976 2258 dbSNP
rs563532066 2259 dbSNP
rs907705779 2271 dbSNP
rs1202935272 2272 dbSNP
rs374288210 2275 dbSNP
rs975986914 2276 dbSNP
rs370262108 2281 dbSNP
rs1272699455 2283 dbSNP
rs1219309391 2284 dbSNP
rs1328213603 2288 dbSNP
rs1293706832 2291 dbSNP
rs1381822489 2308 dbSNP
rs1228736861 2309 dbSNP
rs1361035191 2309 dbSNP
rs1272448228 2310 dbSNP
rs1462983181 2313 dbSNP
rs886048580 2313 dbSNP
rs1343234970 2314 dbSNP
rs1462057369 2321 dbSNP
rs567682286 2322 dbSNP
rs1003041156 2326 dbSNP
rs1195892641 2326 dbSNP
rs1374258116 2326 dbSNP
rs1487751927 2326 dbSNP
rs796540356 2326 dbSNP
rs1491234059 2327 dbSNP
rs867071753 2327 dbSNP
rs11227799 2328 dbSNP
rs1491392197 2328 dbSNP
rs766971670 2328 dbSNP
rs1219080503 2329 dbSNP
rs886048581 2332 dbSNP
rs1263977322 2333 dbSNP
rs1303963183 2334 dbSNP
rs1035864868 2337 dbSNP
rs958912566 2341 dbSNP
rs1325178955 2343 dbSNP
rs1391851477 2345 dbSNP
rs1210696601 2346 dbSNP
rs1398071677 2347 dbSNP
rs1206871042 2348 dbSNP
rs1247451957 2349 dbSNP
rs1013189959 2353 dbSNP
rs1461232183 2358 dbSNP
rs1395297508 2359 dbSNP
rs1175063787 2363 dbSNP
rs1053498892 2364 dbSNP
rs1023698554 2367 dbSNP
rs893530593 2369 dbSNP
rs747686059 2371 dbSNP
rs1440034299 2387 dbSNP
rs1447676585 2387 dbSNP
rs1248557262 2390 dbSNP
rs951728995 2407 dbSNP
rs1193736891 2412 dbSNP
rs1483733391 2421 dbSNP
rs1282749332 2425 dbSNP
rs1232322091 2428 dbSNP
rs1345500780 2430 dbSNP
rs1374728652 2432 dbSNP
rs886048582 2439 dbSNP
rs537752551 2441 dbSNP
rs931674596 2452 dbSNP
rs1326350722 2468 dbSNP
rs1390325139 2468 dbSNP
rs907608927 2468 dbSNP
rs1429521984 2477 dbSNP
rs1050182062 2496 dbSNP
rs1314362930 2515 dbSNP
rs1432427661 2519 dbSNP
rs925058745 2521 dbSNP
rs1159474773 2526 dbSNP
rs547113573 2529 dbSNP
rs975849365 2530 dbSNP
rs923115136 2540 dbSNP
rs1475596660 2547 dbSNP
rs1318162068 2550 dbSNP
rs1259651976 2551 dbSNP
rs1387207312 2554 dbSNP
rs773336845 2559 dbSNP
rs1320849488 2560 dbSNP
rs1279432302 2562 dbSNP
rs1205493704 2567 dbSNP
rs1054992934 2569 dbSNP
rs1352506878 2577 dbSNP
rs1329920826 2582 dbSNP
rs886048583 2584 dbSNP
rs760698045 2585 dbSNP
rs1238189159 2592 dbSNP
rs1232962361 2598 dbSNP
rs1010462766 2607 dbSNP
rs1284374240 2615 dbSNP
rs1355562307 2619 dbSNP
rs1294565226 2631 dbSNP
rs1412584881 2643 dbSNP
rs1050380137 2646 dbSNP
rs571746418 2651 dbSNP
rs1226748829 2657 dbSNP
rs1402819007 2662 dbSNP
rs1383210811 2663 dbSNP
rs183547972 2666 dbSNP
rs1046041244 2668 dbSNP
rs116414393 2669 dbSNP
rs1475038286 2670 dbSNP
rs1381574407 2672 dbSNP
rs1242931128 2679 dbSNP
rs77828276 2680 dbSNP
rs1034429151 2684 dbSNP
rs903231017 2685 dbSNP
rs952190790 2705 dbSNP
rs1439820677 2707 dbSNP
rs189502443 2710 dbSNP
rs192454438 2717 dbSNP
rs1230907597 2727 dbSNP
rs1481306448 2733 dbSNP
rs1270442778 2745 dbSNP
rs1432397408 2750 dbSNP
rs1325100562 2754 dbSNP
rs185206750 2755 dbSNP
rs894665204 2758 dbSNP
rs961883626 2765 dbSNP
rs1397313319 2771 dbSNP
rs1013525837 2774 dbSNP
rs776602987 2776 dbSNP
rs1027226198 2794 dbSNP
rs1453843793 2801 dbSNP
rs540764381 2812 dbSNP
rs571282792 2827 dbSNP
rs975955850 2830 dbSNP
rs145684543 2837 dbSNP
rs1474534667 2839 dbSNP
rs148932555 2861 dbSNP
rs757176022 2862 dbSNP
rs538665266 2869 dbSNP
rs1386666906 2874 dbSNP
rs1468904373 2875 dbSNP
rs1014545078 2881 dbSNP
rs553567809 2882 dbSNP
rs1320618848 2884 dbSNP
rs764991694 2891 dbSNP
rs924976421 2892 dbSNP
rs961735812 2893 dbSNP
rs545186050 2909 dbSNP
rs563492120 2911 dbSNP
rs1336635971 2913 dbSNP
rs923082417 2915 dbSNP
rs1324503579 2930 dbSNP
rs530806797 2946 dbSNP
rs1440747563 2950 dbSNP
rs953194589 2952 dbSNP
rs936395339 2959 dbSNP
rs549335985 2961 dbSNP
rs190045472 2965 dbSNP
rs1408497704 2980 dbSNP
rs752119317 2986 dbSNP
rs757994378 2993 dbSNP
rs528535037 3002 dbSNP
rs1396609792 3003 dbSNP
rs1191723902 3005 dbSNP
rs546681598 3017 dbSNP
rs1241241180 3023 dbSNP
rs1233020808 3026 dbSNP
rs946221027 3027 dbSNP
rs1263794917 3030 dbSNP
rs571674945 3044 dbSNP
rs1221585424 3056 dbSNP
rs907485637 3059 dbSNP
rs1234523721 3062 dbSNP
rs947296179 3065 dbSNP
rs1219196506 3072 dbSNP
rs1301671759 3072 dbSNP
rs1374680508 3080 dbSNP
rs1041687054 3084 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions TZM-bl
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM1462574. RNA binding protein: AGO2. Condition:TZM-bl ami BaL ...

- Whisnant AW; Bogerd HP; Flores O; Ho P; et al., 2013, mBio.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' cauucuucacgaauGUAACGUc 5'
                        ||||||| 
Target 5' -------aucacacCAUUGCAc 3'
 		1 - 15
Article - Whisnant AW; Bogerd HP; Flores O; Ho P; et al.
- mBio, 2013
UNLABELLED: The question of how HIV-1 interfaces with cellular microRNA (miRNA) biogenesis and effector mechanisms has been highly controversial. Here, we first used deep sequencing of small RNAs present in two different infected cell lines (TZM-bl and C8166) and two types of primary human cells (CD4(+) peripheral blood mononuclear cells [PBMCs] and macrophages) to unequivocally demonstrate that HIV-1 does not encode any viral miRNAs. Perhaps surprisingly, we also observed that infection of T cells by HIV-1 has only a modest effect on the expression of cellular miRNAs at early times after infection. Comprehensive analysis of miRNA binding to the HIV-1 genome using the photoactivatable ribonucleoside-induced cross-linking and immunoprecipitation (PAR-CLIP) technique revealed several binding sites for cellular miRNAs, a subset of which were shown to be capable of mediating miRNA-mediated repression of gene expression. However, the main finding from this analysis is that HIV-1 transcripts are largely refractory to miRNA binding, most probably due to extensive viral RNA secondary structure. Together, these data demonstrate that HIV-1 neither encodes viral miRNAs nor strongly influences cellular miRNA expression, at least early after infection, and imply that HIV-1 transcripts have evolved to avoid inhibition by preexisting cellular miRNAs by adopting extensive RNA secondary structures that occlude most potential miRNA binding sites. IMPORTANCE: MicroRNAs (miRNAs) are a ubiquitous class of small regulatory RNAs that serve as posttranscriptional regulators of gene expression. Previous work has suggested that HIV-1 might subvert the function of the cellular miRNA machinery by expressing viral miRNAs or by dramatically altering the level of cellular miRNA expression. Using very sensitive approaches, we now demonstrate that neither of these ideas is in fact correct. Moreover, HIV-1 transcripts appear to largely avoid regulation by cellular miRNAs by adopting an extensive RNA secondary structure that occludes the ability of cellular miRNAs to interact with viral mRNAs. Together, these data suggest that HIV-1, rather than seeking to control miRNA function in infected cells, has instead evolved a mechanism to become largely invisible to cellular miRNA effector mechanisms.
LinkOut: [PMID: 23592263]
CLIP-seq Support 1 for dataset GSM1462574
Method / RBP PAR-CLIP / AGO2
Cell line / Condition TZM-bl / TZM-bl ami BaL
Location of target site ENST00000438189.2 | 3UTR | AUCACACCAUUGCACCCCAGCCUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23592263 / GSE59944
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
GSE28260 Renal cortex and medulla 0.679 5.4e-3 0.742 1.8e-3 13 Click to see details
GSE28544 Breast cancer 0.437 1.6e-2 0.368 3.8e-2 24 Click to see details
GSE19350 CNS germ cell tumors 0.582 2.4e-2 0.481 5.7e-2 12 Click to see details
GSE15076 Monocyte-derived dendritic cells -0.844 3.6e-2 -0.400 2.5e-1 5 Click to see details
GSE21687 Ependynoma primary tumors -0.2 5.7e-2 -0.178 8.0e-2 64 Click to see details
GSE32688 Pancreatic cancer -0.223 1.1e-1 -0.223 1.1e-1 32 Click to see details
GSE34608 Pulmonary tuberculosis and sarcoidosis -0.184 2.2e-1 -0.325 8.1e-2 20 Click to see details
GSE38974 Chronic obstructive pulmonary disease 0.162 2.2e-1 0.158 2.3e-1 25 Click to see details
GSE26953 Aortic valvular endothelial cells -0.141 2.6e-1 0.082 3.5e-1 24 Click to see details
GSE38226 Liver fibrosis 0.146 2.6e-1 0.110 3.2e-1 21 Click to see details
GSE21032 Prostate cancer 0.039 3.6e-1 -0.012 4.6e-1 83 Click to see details
GSE21032 Prostate cancer 0.039 3.6e-1 -0.012 4.6e-1 83 Click to see details
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
KIRP 0.59 0.02 0.412 0.08 13 Click to see details
BRCA -0.513 0.15 -0.714 0.06 6 Click to see details
LIHC -0.875 0.16 -1.000 0.5 3 Click to see details
STAD 0.6 0.2 0.800 0.1 4 Click to see details
KIRC -0.373 0.2 -0.643 0.06 7 Click to see details
KICH -0.232 0.38 0.200 0.4 4 Click to see details
HNSC -0.153 0.4 0.200 0.37 5 Click to see details
PRAD -0.019 0.46 0.023 0.45 37 Click to see details
LUSC -0.049 0.48 -0.200 0.4 4 Click to see details
LUSC -0.049 0.48 -0.200 0.4 4 Click to see details
LUSC -0.049 0.48 -0.200 0.4 4 Click to see details
LUSC -0.049 0.48 -0.200 0.4 4 Click to see details
LUSC -0.049 0.48 -0.200 0.4 4 Click to see details
LUSC -0.049 0.48 -0.200 0.4 4 Click to see details
162 hsa-miR-106a-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT056049 MLLT10 MLLT10, histone lysine methyltransferase DOT1L cofactor 2 2
MIRT065618 CLIC4 chloride intracellular channel 4 2 4
MIRT071648 DICER1 dicer 1, ribonuclease III 2 4
MIRT081712 ZNF507 zinc finger protein 507 2 2
MIRT093589 SPCS3 signal peptidase complex subunit 3 2 2
MIRT094223 G3BP2 G3BP stress granule assembly factor 2 2 2
MIRT125225 KLHL15 kelch like family member 15 2 6
MIRT169562 PNRC1 proline rich nuclear receptor coactivator 1 2 2
MIRT179227 KMT2A lysine methyltransferase 2A 2 2
MIRT180842 RPRD2 regulation of nuclear pre-mRNA domain containing 2 2 2
MIRT248803 SESN2 sestrin 2 2 2
MIRT257843 FAM46A family with sequence similarity 46 member A 2 2
MIRT261799 BUB3 BUB3, mitotic checkpoint protein 2 2
MIRT368750 CDADC1 cytidine and dCMP deaminase domain containing 1 2 2
MIRT448814 FKBP1A FK506 binding protein 1A 2 4
MIRT448950 CDK19 cyclin dependent kinase 19 2 2
MIRT452980 CABP4 calcium binding protein 4 2 2
MIRT454110 MRPL52 mitochondrial ribosomal protein L52 2 2
MIRT456599 CHML CHM like, Rab escort protein 2 2 2
MIRT461652 G6PC glucose-6-phosphatase catalytic subunit 2 2
MIRT464838 RPS27A ribosomal protein S27a 2 12
MIRT469511 RBFOX2 RNA binding protein, fox-1 homolog 2 2 8
MIRT471103 PHLDA2 pleckstrin homology like domain family A member 2 2 2
MIRT475451 HSPA8 heat shock protein family A (Hsp70) member 8 2 6
MIRT478236 DDX3X DEAD-box helicase 3, X-linked 2 4
MIRT480179 CALM2 calmodulin 2 2 8
MIRT481376 ATG12 autophagy related 12 2 2
MIRT495841 PLXDC1 plexin domain containing 1 2 2
MIRT498772 PARP15 poly(ADP-ribose) polymerase family member 15 2 4
MIRT502394 GATA6 GATA binding protein 6 2 8
MIRT504543 ZNF417 zinc finger protein 417 2 6
MIRT504953 ZNRF2 zinc and ring finger 2 2 6
MIRT505044 ZNF226 zinc finger protein 226 2 2
MIRT505285 TRIM66 tripartite motif containing 66 2 6
MIRT508006 BCAT1 branched chain amino acid transaminase 1 2 4
MIRT508372 SPTBN2 spectrin beta, non-erythrocytic 2 2 4
MIRT509026 PALM2-AKAP2 PALM2-AKAP2 readthrough 2 2
MIRT509045 AKAP2 A-kinase anchoring protein 2 2 2
MIRT509640 ZNF354B zinc finger protein 354B 2 10
MIRT512961 KMO kynurenine 3-monooxygenase 2 4
MIRT517859 NCAPD2 non-SMC condensin I complex subunit D2 2 4
MIRT517944 TRIM59 tripartite motif containing 59 2 2
MIRT525900 BUB1 BUB1 mitotic checkpoint serine/threonine kinase 2 2
MIRT529446 SLC28A2 solute carrier family 28 member 2 2 2
MIRT531095 PEX13 peroxisomal biogenesis factor 13 2 2
MIRT534557 RRAS2 RAS related 2 2 2
MIRT537004 GTF2A1 general transcription factor IIA subunit 1 2 2
MIRT538407 COX20 COX20, cytochrome c oxidase assembly factor 2 2
MIRT540635 SUMO1 small ubiquitin-like modifier 1 2 2
MIRT546660 RPS6KA5 ribosomal protein S6 kinase A5 2 2
MIRT547958 HIGD1A HIG1 hypoxia inducible domain family member 1A 2 4
MIRT552022 DNAJC10 DnaJ heat shock protein family (Hsp40) member C10 2 2
MIRT554238 SLBP stem-loop binding protein 2 2
MIRT555287 PPP6R1 protein phosphatase 6 regulatory subunit 1 2 2
MIRT556139 MFF mitochondrial fission factor 2 2
MIRT556419 LONRF3 LON peptidase N-terminal domain and ring finger 3 2 2
MIRT557258 HMGXB4 HMG-box containing 4 2 2
MIRT557318 HIF1A hypoxia inducible factor 1 alpha subunit 2 2
MIRT557774 FRS2 fibroblast growth factor receptor substrate 2 2 2
MIRT559634 AKAP10 A-kinase anchoring protein 10 2 2
MIRT561616 SESN3 sestrin 3 2 2
MIRT566174 PURA purine rich element binding protein A 2 2
MIRT567183 IGFBP5 insulin like growth factor binding protein 5 2 2
MIRT611357 LARP4B La ribonucleoprotein domain family member 4B 2 2
MIRT616553 ZNF512B zinc finger protein 512B 2 2
MIRT617308 FAM9C family with sequence similarity 9 member C 2 2
MIRT624899 AAGAB alpha and gamma adaptin binding protein 2 2
MIRT627008 FIG4 FIG4 phosphoinositide 5-phosphatase 2 2
MIRT627071 SF3A1 splicing factor 3a subunit 1 2 2
MIRT628271 CYB5D1 cytochrome b5 domain containing 1 2 2
MIRT629231 CINP cyclin dependent kinase 2 interacting protein 2 2
MIRT629403 ADM2 adrenomedullin 2 2 2
MIRT629580 RFC2 replication factor C subunit 2 2 2
MIRT629631 WDR31 WD repeat domain 31 2 2
MIRT629796 GPR82 G protein-coupled receptor 82 2 2
MIRT629870 NOM1 nucleolar protein with MIF4G domain 1 2 2
MIRT629916 POLR2D RNA polymerase II subunit D 2 2
MIRT629979 NARS asparaginyl-tRNA synthetase 2 2
MIRT630038 TERF2 telomeric repeat binding factor 2 2 2
MIRT630057 NIP7 NIP7, nucleolar pre-rRNA processing protein 2 2
MIRT630151 ZBTB8A zinc finger and BTB domain containing 8A 2 2
MIRT630245 SMTNL2 smoothelin like 2 2 2
MIRT630274 PSMB5 proteasome subunit beta 5 2 2
MIRT630344 NKAP NFKB activating protein 2 2
MIRT630493 CYP20A1 cytochrome P450 family 20 subfamily A member 1 2 2
MIRT631628 ZNF383 zinc finger protein 383 2 2
MIRT632467 RPS15A ribosomal protein S15a 2 2
MIRT632509 RAB11FIP1 RAB11 family interacting protein 1 2 2
MIRT632591 PDP2 pyruvate dehyrogenase phosphatase catalytic subunit 2 2 2
MIRT632989 DUSP18 dual specificity phosphatase 18 2 2
MIRT633077 CXorf21 chromosome X open reading frame 21 2 2
MIRT635044 MYH11 myosin heavy chain 11 2 2
MIRT636646 CDK4 cyclin dependent kinase 4 2 2
MIRT637185 ROMO1 reactive oxygen species modulator 1 2 2
MIRT637918 LILRA2 leukocyte immunoglobulin like receptor A2 2 2
MIRT642640 PTGR2 prostaglandin reductase 2 2 2
MIRT644231 SLC35E3 solute carrier family 35 member E3 2 2
MIRT644659 TMCO1 transmembrane and coiled-coil domains 1 2 2
MIRT645084 SLC35E2B solute carrier family 35 member E2B 2 2
MIRT645985 ACP6 acid phosphatase 6, lysophosphatidic 2 2
MIRT646980 SCARB1 scavenger receptor class B member 1 2 2
MIRT647421 ODF4 outer dense fiber of sperm tails 4 2 2
MIRT648322 PLIN1 perilipin 1 2 2
MIRT648506 PIGG phosphatidylinositol glycan anchor biosynthesis class G 2 2
MIRT651460 XIAP X-linked inhibitor of apoptosis 2 2
MIRT656548 LZIC leucine zipper and CTNNBIP1 domain containing 2 2
MIRT657371 HMGB1 high mobility group box 1 2 2
MIRT660828 AGO3 argonaute 3, RISC catalytic component 2 2
MIRT660916 ADAM19 ADAM metallopeptidase domain 19 2 2
MIRT661232 ARL17B ADP ribosylation factor like GTPase 17B 2 2
MIRT662840 OMD osteomodulin 2 2
MIRT662902 MED18 mediator complex subunit 18 2 2
MIRT663518 MASTL microtubule associated serine/threonine kinase like 2 2
MIRT663537 CCR6 C-C motif chemokine receptor 6 2 2
MIRT664345 C16orf45 chromosome 16 open reading frame 45 2 2
MIRT666074 SSTR2 somatostatin receptor 2 2 2
MIRT667219 NFE2L1 nuclear factor, erythroid 2 like 1 2 2
MIRT667756 KDELR1 KDEL endoplasmic reticulum protein retention receptor 1 2 2
MIRT668647 DYM dymeclin 2 2
MIRT671471 FLYWCH2 FLYWCH family member 2 2 2
MIRT671488 SLC38A9 solute carrier family 38 member 9 2 2
MIRT671917 PLEKHS1 pleckstrin homology domain containing S1 2 4
MIRT672285 GP2 glycoprotein 2 2 2
MIRT674022 ANKRD9 ankyrin repeat domain 9 2 2
MIRT674212 FAM120AOS family with sequence similarity 120A opposite strand 2 2
MIRT674510 PRR23A proline rich 23A 2 2
MIRT675095 SNTB2 syntrophin beta 2 2 2
MIRT675261 ZNF431 zinc finger protein 431 2 2
MIRT680630 KIAA1456 KIAA1456 2 2
MIRT681609 F2RL2 coagulation factor II thrombin receptor like 2 2 2
MIRT681919 KAT7 lysine acetyltransferase 7 2 2
MIRT682042 MRPS10 mitochondrial ribosomal protein S10 2 2
MIRT682055 B4GALT7 beta-1,4-galactosyltransferase 7 2 4
MIRT683756 CPE carboxypeptidase E 2 2
MIRT690233 CENPK centromere protein K 2 2
MIRT699167 SMAD2 SMAD family member 2 2 2
MIRT699905 RUNDC1 RUN domain containing 1 2 2
MIRT704401 CTPS1 CTP synthase 1 2 2
MIRT706252 MKLN1 muskelin 1 2 2
MIRT708876 MOCS2 molybdenum cofactor synthesis 2 2 2
MIRT710788 IFNLR1 interferon lambda receptor 1 2 2
MIRT711947 SLC7A14 solute carrier family 7 member 14 2 2
MIRT712587 ADCYAP1 adenylate cyclase activating polypeptide 1 2 2
MIRT713335 KLRD1 killer cell lectin like receptor D1 2 2
MIRT713901 IGF2R insulin like growth factor 2 receptor 2 2
MIRT714079 ZNF532 zinc finger protein 532 2 2
MIRT714881 GOLPH3 golgi phosphoprotein 3 2 2
MIRT715190 FKTN fukutin 2 2
MIRT717798 FAM114A1 family with sequence similarity 114 member A1 2 2
MIRT721434 ARPC4 actin related protein 2/3 complex subunit 4 2 2
MIRT722777 PDE3A phosphodiesterase 3A 2 2
MIRT723415 FAM208B family with sequence similarity 208 member B 2 2
MIRT732545 AURKA aurora kinase A 1 0
MIRT732549 MYCN MYCN proto-oncogene, bHLH transcription factor 1 0
MIRT733122 YAP1 Yes associated protein 1 3 0
MIRT733238 VEGFA vascular endothelial growth factor A 1 0
MIRT733725 TGFB1 transforming growth factor beta 1 2 0
MIRT733728 NOTCH1 notch 1 2 0
MIRT733829 RUNX2 runt related transcription factor 2 1 0
MIRT733830 BMP2 bone morphogenetic protein 2 1 0
MIRT736953 SMAD7 SMAD family member 7 3 0
MIRT737029 FOXQ1 forkhead box Q1 3 0
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-106a Cisplatin approved 84093 Quantitative real-time PCR ovarian cancer cells 24348845 2014 up-regulated
miR-106a Cisplatin approved 84093 Microarray ovarian cancer 19237188 2009 down-regulated
miR-106a Vorinostat (SAHA) approved 5311 Microarray A549 human non-small cell lung cancer cells 19513533 2009 down-regulated
miR-106a Diethylstilbestrol approved 448537 Microarray mammosphere-derived epithelial cells (MDEC) 19549897 2009 down-regulated
miR-106a Diethylstilbestrol approved 448537 Quantitative real-time PCR mammosphere-derived epithelial cells (MDEC) 19549897 2009 down-regulated
miR-106a 5-Fluorouracil approved 3385 Microarray HCT-8 colon cancer cell line 19956872 2010 down-regulated
miR-106a Bisphenol A NULL 6623 Microarray immortalized cytotrophoblast cell lines HTR-8 20417706 2010 up-regulated
miR-106a Formaldehyde NULL 712 Microarray Human lung epithelial cells (A549) 21147603 2011 down-regulated
miR-106a Bicalutamide approved 2375 Microarray prostate 22674191 2012 down-regulated
miR-106a Narangin NULL 442428 Microarray apoE−/− mice 22253797 2012 up-regulated
miR-106a Tamoxifen approved 2733526 Microarray rat liver 17343880 2007 up-regulated
miR-106a Tamoxifen approved 2733526 Quantitative real-time PCR rat liver 17343880 2007 up-regulated
miR-106a 17beta-estradiol (E2) approved 5757 Microarray rat breast 17700064 2007 up-regulated
miR-106a 17beta-estradiol (E2) approved 5757 Quantitative real-time PCR rat breast 17700064 2007 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-106a-3p Docetaxel 148124 NSC628503 approved resistant High Breast Cancer cell line (BT-20, BT-474, BT-549, CAMA-1, HCC1143, HCC1395, HCC1569, HCC1806, HCC-1937, HCC1954, HCC202, HCC38, HCC70, Hs578T, MCF-7, MDA-MB-175VII, MDA-MB-231, MDA-MB-361, MDA-MB-415, MDA-MB-436, MDA-MB-468, SKBR3, T47D, UACC812, EVSA-T, MPE-600 , SK-BR-
hsa-miR-106a-3p Paclitaxel 36314 NSC125973 approved resistant High Breast Cancer cell line (BT-20, BT-474, BT-549, CAMA-1, HCC1143, HCC1395, HCC1569, HCC1806, HCC-1937, HCC1954, HCC202, HCC38, HCC70, Hs578T, MCF-7, MDA-MB-175VII, MDA-MB-231, MDA-MB-361, MDA-MB-415, MDA-MB-436, MDA-MB-468, SKBR3, T47D, UACC812, EVSA-T, MPE-600 , SK-BR-
hsa-miR-106a-3p Apatinib 11315474 NSC772886 resistant Low Gastric Cancer cell line (SGC-7901)
hsa-miR-106a-3p Sunitinib 5329102 NSC750690 approved resistant tissue (CardB)
hsa-miR-106a-3p Cisplatin 5460033 NSC119875 approved resistant cell line (IGROV-1)
hsa-miR-106a-3p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-106a-3p Neoadjuvant chemotherapy sensitive tissue (breast cancer)
hsa-miR-106a-3p Paclitaxel/Docetaxel/Vinorelbine/Doxorubicin/Etoposide resistant cell line (Bads-200)

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