miRTarBase - #MIRT452990


—
pre-miRNA Information
pre-miRNA hsa-mir-4731   
Genomic Coordinates chr17: 15251627 - 15251696
Description Homo sapiens miR-4731 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-4731-5p
Sequence 10| UGCUGGGGGCCACAUGAGUGUG |31
Evidence Experimental
Experiments Illumina
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1295173963 9 dbSNP
rs1227560397 15 dbSNP
rs972231157 18 dbSNP
Putative Targets

Gene Information
Gene Symbol CABP4   
Synonyms CRSD, CSNB2B
Description calcium binding protein 4
Transcript NM_145200   
Expression
Putative miRNA Targets on CABP4
3'UTR of CABP4
(miRNA target sites are highlighted)		 
>CABP4|NM_145200|3'UTR
   1 GGCTCCAGGAGGGAATATCTGTTGCCCCTGCGGCCCCAGACACCAGCCAGACCCAGGCTGCAGGCCTCCCCCAGGAGCCT
  81 CCAGGATGGAGATGGAGACCCAGCAGCCCCCAGACTACTTCTATCCCTGAAAACACCTGGCCTCAATGTTGGCTTGTTAT
 161 GTTACCTGCCCACCCTCATCCTTACCTCCTCCTACTCAAGCTGCCTGGAGAAGACCTGCTCTCAGCTGCCCACCGTTCCT
 241 CAGTGTGAGCAAGATTTGGGTCTCTCCAGACCTCTGGGAGGTAGGGAGTTCCCTGGCACTGGCAGCATTCAGTGGGGACC
 321 CCCCAGTGGCATGATGAATGGAGAGGATGGCTGGACCCCTTCCACTACTTATGTTTATAATTTTTTTTTTTTTTAATGAA
 401 CTTGAGCCGGGTGCAGTGGCTCACACCTGTAAGCCCAGCTGTCAGGGGGCAGAAGCGGGAGGATAGCTTGAGCCCAGGAG
 481 TGCAAGACCTGCCTGGGCAATATACTGAGACCCCATTCTCCACAAAAAGGAAAAATAAAAGACAAAAAAACAAACAAAAA
 561 ACCAAAAAACCCAAGTGTAAAAAAAGTGAGCTTGAAAGAAAGAAAGGGATGGCTCCATGTATCAAAGACAAAGAAATCAA
 641 AGCTGGGGTTGTAAGAGGGAGCTGACGCTGTGGGGGTTTCAGATCTGGATGGAGGCTTGGCCGCCTGGACTCCTACAACC
 721 ATGAGTGACAGAAGAACCATATGAGTCTGGGGAGCAAGAAACAAACCCCCCGGATATATTCCAGGGTCTCCAAAGGCTAA
 801 GATATTAATCTGTCTGCACTGACCAGTCATAGAAAGTGGCAAGGATACAGATGTTCAGGGCCCAGAGTGGAAACAGCTGC
 881 CCTAAAGAGCCTGGAACTCCAGGGCCTGCCCTTCAAGCAGGCGTGTAGTCTCTCTCCAGGGTGTGAAAAACTGGAAAAAA
 961 ACCCTGCCGCTCCCAAAGGGGAACTTGTGATAAAAATTACAGATTATTGGGCTGGGAGTGGTGGCTCACGCCTGTAATCC
1041 CAGCACTTTGGGAGGCTGAGGCGGGTGAATTACCTGAGGTCAGGAGTTTGAGGCCAGCCTGACCAACATGGTGAAACCCC
1121 ATCTCTACTAAAAATACAAAAATTAACTGGGCGAGGTAGCATGCACCTGTAATCTCAGCTACTCGGAGGTTGAGGCAGGA
1201 GAATCGCTTGAGCCCGGGAGGTGGAGCTGCAGTGAGCTGAGATCACACCATTGCACCCCAGCCTGAGCAACAGATCGAGA
1281 CTCCGTCTCAAAAACAAAACAAAAAAACCATACTGATTATAAAAGTAAAGAAACCACCATGAAGGAGACGAGACAGAGAC
1361 AAAAACAAGAGGACTGGCATCTCAGTGTACATAATACAGCCGCCTAAGAGACCACAAGATACATGCAAATAAAAGACGGC
1441 TAAAAGGGGAAGAGAGATCAACATGCAGTAACAGGATAGTATGAAGAGAGAACCGGAAGATTTAAAAAGTAACCCAACAG
1521 GCCAGGCGCATGGCTCATGCCTGGAATCCCAGCACTTTGGGAGGCCAAGGTGGGTGGGTTGCTTGAGCTCAGGAATTCGA
1601 GACCAGCCTGGGCAACATGGTGAAACCCTGTCTCTACTAAAAATACAAAAATTAGCCAGGCGTGGTGGTGCTTGCATCTG
1681 TGGTCCCAGGTATTCTACAGGCTGAGGTGGGAGGATCACTTGAGCCCAGGAGGCAGAGGTTGCAGTGAGTCGAGATCGCA
1761 CCACTGCACTCCAGCGTGGGTAACAGAGTGAGAATCCGTCAAAAAGAAAAAAACAAACCATGGCTTCTGTTAAAAAAATA
1841 AAGTATATTTTATATATACACACACACACACACACACACACACAGCCATTGGAATGAAAAAATAATGGATAAGCTAAACA
1921 GCAGATTAAACACAATTTAAAGATTAATGAACTGGAAGCTATATCTAAGAAATCACTTATAATGTAACACTGAGAGACAA
2001 AAGGATGGAAAATATTACAGGGTAGTTAAAAGTCACTGGAAGGCTGGGTGTGGTGGCTCACGCCTGTAATCCCAGCACTT
2081 TGGGAGGCTGAGACGGGCGGGTCACAGGGTCAGGAGATCGAGACCATCCTGGCTAACACAGTGAAACCCCATCTCTACTA
2161 AAAATACAAAAAAAAATTAGCTGGGCGTGGTGGCGGGCGCCTGTAGTCCCAGCTACTAGGGAGGCTGAGGCAAGAGAATG
2241 GCGTGAACCCAGGAGGCGGAGCTTGCAGTGAGCCGAGATTGCACCACTGCACTCCAGCCTGGGCTACAGAGCGAGACTCC
2321 GTCTCGGAAAAAAAAAAAAAAAAAGGTCACTGGAAGACTGGGTGTGGTGGCTTATGCCTGTAATCCCAGCATTTTGGGAG
2401 GCTAAGGCAGGAGGATCACTTGAGGCCAGGAGTTTGAGACCAGCCTAACAGCAAGACCCTGCCTCTTAAAAAAAATAATA
2481 AAAAAATAAGCTGGGTGTAGTGGCTCATGCTTGTAGTTCCAGCTATTCAGGAGGCTGAGGTGAGAGGATCATTTGAGCCC
2561 AGGAGTTGGAGGCTGCAGTGATCGTGCCACTGCACTCCAGCCTTGGTGACAGAGCAAGAGACCCTGTCTCAAAGAAAAAG
2641 ACAGATAAGTCCTTGGGAGTCTCAGACGGAGGACATACATAGAGAATGAACAAGAAGCAATAACCAAAGAGATAATGGCT
2721 GAAAATTTTCCATAAAGACTTCCACAGACTTCAACTCCCCAGATTGAAGGAACAAACTGAAGTCAGAGTAGGGTAAATAA
2801 AAATAAATATATATCTGGATATATCCCATTGAAACCACAGAATATAAAAAGCAAATCTTATAAATAACTGGAGAGAAAAG
2881 TCAGATTCACGGTGTTCTGTCAAAGTGTTCATGTAGACTAAGGGTGGGGAAACTTTCTGTAAAGGGCTGGAGAATAATTA
2961 TTTTCAGCTTTGAGGCTTTGGTCTCTGTTGCAGCTGCTCACGCAACTCTGCTGTTGAAGTTTGTAGTGCAAAGTCAAGTC
3041 AACAAATGAGTGTGGCTATATCAGAAATTTTAATAAATAACAGTAAAACTTCATTTATTGACATGGAAATTTGAAAAAAA
3121 AAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' guGUGAGUACACCGGGGGUCGu 5'
            ||| ||| ||  ||||||| 
Target 5' caCAC-CAT-TGCACCCCAGCc 3'
 1244 - 1263 158.00 -21.60
2 
miRNA  3' guGUGAGU-ACACC--GGGGGUCGu 5'
            ||:||| || ||  |||||||: 
Target 5' agCATTCAGTGGGGACCCCCCAGTg 3'
 304 - 328 154.00 -26.50
3 
miRNA  3' gugUGAGUAC--ACC-GGGGGUCGu 5'
             :||||||  |||  :|||||| 
Target 5' atgGCTCATGCCTGGAATCCCAGCa 3'
 1530 - 1554 149.00 -24.50
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
305662 27 ClinVar
879587 63 ClinVar
305663 120 ClinVar
305664 121 ClinVar
305665 263 ClinVar
879938 296 ClinVar
305666 325 ClinVar
305667 381 ClinVar
879939 395 ClinVar
879940 409 ClinVar
305668 670 ClinVar
305669 682 ClinVar
305670 684 ClinVar
877142 703 ClinVar
305671 877 ClinVar
305672 964 ClinVar
305673 1041 ClinVar
877143 1064 ClinVar
305674 1118 ClinVar
877144 1159 ClinVar
878175 1191 ClinVar
305675 1224 ClinVar
305676 1286 ClinVar
305677 1292 ClinVar
305678 1391 ClinVar
878176 1393 ClinVar
878177 1403 ClinVar
878178 1414 ClinVar
305679 1436 ClinVar
879630 1511 ClinVar
305680 1528 ClinVar
879631 1637 ClinVar
879632 1663 ClinVar
305681 1698 ClinVar
879633 1759 ClinVar
305682 1807 ClinVar
305683 1828 ClinVar
305684 1851 ClinVar
305685 1851 ClinVar
305686 1854 ClinVar
305687 1856 ClinVar
305688 1856 ClinVar
305689 1856 ClinVar
305690 1858 ClinVar
305691 1858 ClinVar
305692 1858 ClinVar
305693 1858 ClinVar
305694 1858 ClinVar
305695 1858 ClinVar
305696 1858 ClinVar
305697 1858 ClinVar
305698 1860 ClinVar
305699 1860 ClinVar
879996 1874 ClinVar
305700 1878 ClinVar
305701 1934 ClinVar
305702 1940 ClinVar
879997 1958 ClinVar
879998 2001 ClinVar
879999 2005 ClinVar
877199 2062 ClinVar
305703 2066 ClinVar
305704 2090 ClinVar
305705 2099 ClinVar
305706 2168 ClinVar
877200 2187 ClinVar
305707 2188 ClinVar
305708 2196 ClinVar
305709 2313 ClinVar
305710 2326 ClinVar
305711 2328 ClinVar
305712 2332 ClinVar
878240 2358 ClinVar
305713 2439 ClinVar
305714 2584 ClinVar
305715 2669 ClinVar
305716 2680 ClinVar
305717 2710 ClinVar
878241 2717 ClinVar
879691 2837 ClinVar
879692 2861 ClinVar
879693 2887 ClinVar
879694 2897 ClinVar
879695 2906 ClinVar
879696 2959 ClinVar
305718 3044 ClinVar
COSN30144284 12 COSMIC
COSN30181513 14 COSMIC
COSN30468557 14 COSMIC
COSN31552930 20 COSMIC
COSN30191461 32 COSMIC
COSN26968906 33 COSMIC
COSN30127146 60 COSMIC
COSN30465366 85 COSMIC
COSN31488333 86 COSMIC
COSN31488570 92 COSMIC
COSN31543163 104 COSMIC
COSN30151751 110 COSMIC
COSN30190431 118 COSMIC
COSN507354 119 COSMIC
COSN31591465 210 COSMIC
COSN20508842 250 COSMIC
COSN5917089 478 COSMIC
COSN22828700 604 COSMIC
COSN26753350 689 COSMIC
COSN21789045 782 COSMIC
COSN15082637 857 COSMIC
COSN15122750 858 COSMIC
COSN27609208 962 COSMIC
COSN24428689 1296 COSMIC
COSN22739937 1361 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs569872151 5 dbSNP
rs898778158 5 dbSNP
rs748195294 6 dbSNP
rs749036787 7 dbSNP
rs931592206 10 dbSNP
rs758583912 13 dbSNP
rs777890480 20 dbSNP
rs887134726 26 dbSNP
rs747352890 27 dbSNP
rs1008239273 30 dbSNP
rs771250959 31 dbSNP
rs529589052 32 dbSNP
rs1019686545 33 dbSNP
rs1286938410 36 dbSNP
rs548141133 38 dbSNP
rs202212392 40 dbSNP
rs560082251 44 dbSNP
rs773852144 47 dbSNP
rs1440317899 49 dbSNP
rs899658098 63 dbSNP
rs1481119889 73 dbSNP
rs1207224203 81 dbSNP
rs1200358058 90 dbSNP
rs1456293091 93 dbSNP
rs996674799 119 dbSNP
rs1790736 120 dbSNP
rs372107215 121 dbSNP
rs1313826199 122 dbSNP
rs1032080797 129 dbSNP
rs570414838 148 dbSNP
rs1373661841 150 dbSNP
rs1332932149 152 dbSNP
rs1444061611 158 dbSNP
rs1400027868 161 dbSNP
rs1337734059 162 dbSNP
rs760779526 166 dbSNP
rs977366671 168 dbSNP
rs769163963 169 dbSNP
rs1021210075 171 dbSNP
rs1419723853 175 dbSNP
rs1265404246 176 dbSNP
rs537566910 186 dbSNP
rs1177038816 187 dbSNP
rs1439247033 189 dbSNP
rs1237358902 193 dbSNP
rs970600317 195 dbSNP
rs549538705 196 dbSNP
rs1031729385 207 dbSNP
rs1254144706 222 dbSNP
rs1198018314 226 dbSNP
rs1378144279 231 dbSNP
rs567943756 235 dbSNP
rs1317016447 236 dbSNP
rs1310722336 251 dbSNP
rs886048562 263 dbSNP
rs1375674961 270 dbSNP
rs772851120 282 dbSNP
rs1316250466 287 dbSNP
rs959705498 292 dbSNP
rs181113902 296 dbSNP
rs769973044 297 dbSNP
rs1400752403 298 dbSNP
rs1302798525 300 dbSNP
rs1454725603 308 dbSNP
rs992562538 313 dbSNP
rs1156868188 314 dbSNP
rs1419392913 314 dbSNP
rs1184017178 319 dbSNP
rs926587486 319 dbSNP
rs886048563 325 dbSNP
rs1253764465 331 dbSNP
rs143907498 348 dbSNP
rs973429498 357 dbSNP
rs948197685 367 dbSNP
rs1322174679 369 dbSNP
rs553822363 369 dbSNP
rs1169445927 381 dbSNP
rs1216209571 381 dbSNP
rs3835327 381 dbSNP
rs397744121 381 dbSNP
rs920111245 381 dbSNP
rs1312372561 387 dbSNP
rs931535237 388 dbSNP
rs1385748058 393 dbSNP
rs1047325440 395 dbSNP
rs1333400343 407 dbSNP
rs376738871 409 dbSNP
rs775755989 410 dbSNP
rs572401751 412 dbSNP
rs890625688 414 dbSNP
rs1366507080 416 dbSNP
rs944938776 419 dbSNP
rs1226929496 423 dbSNP
rs1265204938 425 dbSNP
rs148612796 428 dbSNP
rs1487688393 435 dbSNP
rs765865925 446 dbSNP
rs944066488 447 dbSNP
rs1353751299 449 dbSNP
rs1265284766 452 dbSNP
rs900793504 457 dbSNP
rs1320673422 458 dbSNP
rs1230417616 462 dbSNP
rs1276836025 465 dbSNP
rs1263920697 466 dbSNP
rs1041108595 468 dbSNP
rs368995514 474 dbSNP
rs1325537662 476 dbSNP
rs141182457 490 dbSNP
rs996462572 495 dbSNP
rs899960922 500 dbSNP
rs1292765443 511 dbSNP
rs1465923688 521 dbSNP
rs1210510864 530 dbSNP
rs866365965 531 dbSNP
rs1168484516 537 dbSNP
rs185956229 537 dbSNP
rs1032463264 544 dbSNP
rs1477416311 544 dbSNP
rs1200357135 548 dbSNP
rs1266194749 551 dbSNP
rs1449582587 551 dbSNP
rs879146930 554 dbSNP
rs1196796157 556 dbSNP
rs893518473 557 dbSNP
rs1256520001 558 dbSNP
rs1218573934 562 dbSNP
rs996894148 563 dbSNP
rs1021837690 564 dbSNP
rs1179715377 565 dbSNP
rs576577876 570 dbSNP
rs1231117103 579 dbSNP
rs1330789985 594 dbSNP
rs970566236 598 dbSNP
rs1449224731 607 dbSNP
rs981965286 610 dbSNP
rs1328974267 611 dbSNP
rs1472810116 616 dbSNP
rs999148826 619 dbSNP
rs1173862726 622 dbSNP
rs1031614278 630 dbSNP
rs1376528703 630 dbSNP
rs1178903154 632 dbSNP
rs973423917 634 dbSNP
rs763174697 636 dbSNP
rs1198400996 638 dbSNP
rs1366358298 642 dbSNP
rs1281319124 645 dbSNP
rs1199193274 652 dbSNP
rs1344436403 653 dbSNP
rs1280142798 663 dbSNP
rs1242603700 665 dbSNP
rs1374936119 667 dbSNP
rs886048564 670 dbSNP
rs992529853 676 dbSNP
rs920592912 678 dbSNP
rs543961015 682 dbSNP
rs146218513 684 dbSNP
rs1307992452 686 dbSNP
rs973196092 696 dbSNP
rs1412075901 700 dbSNP
rs1158667047 702 dbSNP
rs574323434 703 dbSNP
rs931528297 704 dbSNP
rs1178477526 708 dbSNP
rs1039213424 717 dbSNP
rs1239512128 721 dbSNP
rs1321414689 726 dbSNP
rs1186090062 730 dbSNP
rs900760872 742 dbSNP
rs1218845768 743 dbSNP
rs983421024 749 dbSNP
rs1261423516 758 dbSNP
rs1351864401 762 dbSNP
rs1285561785 763 dbSNP
rs1245588393 766 dbSNP
rs908838478 766 dbSNP
rs944033759 769 dbSNP
rs1445758993 771 dbSNP
rs768551163 772 dbSNP
rs1298352851 797 dbSNP
rs1401299151 802 dbSNP
rs1053423532 805 dbSNP
rs541706301 806 dbSNP
rs1157682690 808 dbSNP
rs1405554073 824 dbSNP
rs932714164 827 dbSNP
rs1009294284 836 dbSNP
rs1021105232 838 dbSNP
rs1251006534 841 dbSNP
rs1483222420 844 dbSNP
rs1161804290 847 dbSNP
rs79733334 849 dbSNP
rs1178799409 861 dbSNP
rs189731301 867 dbSNP
rs1253627122 871 dbSNP
rs1422928664 874 dbSNP
rs1196008973 876 dbSNP
rs11601325 877 dbSNP
rs1262478665 885 dbSNP
rs1386517161 890 dbSNP
rs577168001 895 dbSNP
rs144432491 898 dbSNP
rs1291816209 910 dbSNP
rs1053440744 915 dbSNP
rs895704948 918 dbSNP
rs543364807 923 dbSNP
rs1463844366 931 dbSNP
rs1301512786 932 dbSNP
rs1014185430 943 dbSNP
rs1022616472 944 dbSNP
rs1296989290 954 dbSNP
rs1436816148 955 dbSNP
rs985262502 962 dbSNP
rs76060170 964 dbSNP
rs531286246 965 dbSNP
rs1363053011 968 dbSNP
rs952991190 969 dbSNP
rs183419313 970 dbSNP
rs908722536 973 dbSNP
rs1489609850 978 dbSNP
rs1273822665 997 dbSNP
rs567905142 1006 dbSNP
rs1245192307 1012 dbSNP
rs1342856446 1013 dbSNP
rs965561444 1014 dbSNP
rs1258425824 1016 dbSNP
rs1200480939 1027 dbSNP
rs976989097 1030 dbSNP
rs1254067643 1031 dbSNP
rs911970986 1039 dbSNP
rs921234184 1040 dbSNP
rs186530202 1041 dbSNP
rs1272730821 1061 dbSNP
rs1043515263 1063 dbSNP
rs191030743 1064 dbSNP
rs911158058 1067 dbSNP
rs926096677 1081 dbSNP
rs922113011 1086 dbSNP
rs1400164098 1087 dbSNP
rs934751519 1091 dbSNP
rs1447054521 1104 dbSNP
rs1187454980 1110 dbSNP
rs565802060 1118 dbSNP
rs1430853408 1119 dbSNP
rs913507993 1127 dbSNP
rs750151193 1153 dbSNP
rs1238615561 1154 dbSNP
rs539741322 1159 dbSNP
rs1042087608 1171 dbSNP
rs1466889586 1184 dbSNP
rs1250677612 1185 dbSNP
rs183186439 1186 dbSNP
rs906278630 1187 dbSNP
rs1014152940 1189 dbSNP
rs1044363688 1190 dbSNP
rs7127024 1191 dbSNP
rs760609909 1202 dbSNP
rs1377151198 1203 dbSNP
rs537531908 1207 dbSNP
rs1434446461 1211 dbSNP
rs994551641 1212 dbSNP
rs766112266 1213 dbSNP
rs1303943645 1216 dbSNP
rs753487920 1217 dbSNP
rs1362535365 1218 dbSNP
rs754686225 1219 dbSNP
rs555941085 1224 dbSNP
rs994738513 1230 dbSNP
rs1382399898 1236 dbSNP
rs574182345 1238 dbSNP
rs1361901348 1240 dbSNP
rs11605548 1248 dbSNP
rs11601405 1254 dbSNP
rs1180338773 1258 dbSNP
rs1437608423 1266 dbSNP
rs965531117 1277 dbSNP
rs976957802 1278 dbSNP
rs373857371 1286 dbSNP
rs146149609 1292 dbSNP
rs1463310384 1296 dbSNP
rs1207523241 1301 dbSNP
rs1237427088 1304 dbSNP
rs553549818 1309 dbSNP
rs1018904896 1310 dbSNP
rs966067375 1313 dbSNP
rs974811513 1314 dbSNP
rs1189929826 1315 dbSNP
rs188509571 1319 dbSNP
rs922081352 1325 dbSNP
rs1419285044 1330 dbSNP
rs1425090335 1338 dbSNP
rs957752708 1341 dbSNP
rs978816890 1348 dbSNP
rs1434117353 1350 dbSNP
rs990362258 1351 dbSNP
rs1186670819 1359 dbSNP
rs1488336454 1361 dbSNP
rs913466747 1367 dbSNP
rs140203885 1373 dbSNP
rs1410005977 1378 dbSNP
rs925951731 1386 dbSNP
rs564944745 1391 dbSNP
rs77807407 1393 dbSNP
rs917076132 1400 dbSNP
rs1247440749 1402 dbSNP
rs949888937 1403 dbSNP
rs1320502483 1405 dbSNP
rs1044334296 1409 dbSNP
rs1291641601 1411 dbSNP
rs563724143 1414 dbSNP
rs781743235 1419 dbSNP
rs930563507 1420 dbSNP
rs547381974 1424 dbSNP
rs1048683968 1425 dbSNP
rs75914794 1436 dbSNP
rs1391680651 1438 dbSNP
rs1326861151 1449 dbSNP
rs543111733 1452 dbSNP
rs1004606330 1456 dbSNP
rs1415314102 1460 dbSNP
rs1227347630 1464 dbSNP
rs1268388559 1465 dbSNP
rs1478080721 1472 dbSNP
rs1448156154 1476 dbSNP
rs995072854 1477 dbSNP
rs1018678633 1481 dbSNP
rs1048928134 1483 dbSNP
rs1487711974 1491 dbSNP
rs1272900202 1494 dbSNP
rs1320593584 1495 dbSNP
rs561400843 1495 dbSNP
rs528993456 1496 dbSNP
rs1226775997 1500 dbSNP
rs1331954508 1506 dbSNP
rs1303691994 1511 dbSNP
rs547246461 1528 dbSNP
rs192714120 1538 dbSNP
rs1392054802 1541 dbSNP
rs1028521441 1546 dbSNP
rs1202002260 1556 dbSNP
rs1466116876 1575 dbSNP
rs533060454 1582 dbSNP
rs551692608 1589 dbSNP
rs1402368372 1590 dbSNP
rs570061594 1596 dbSNP
rs1165710954 1600 dbSNP
rs1018872418 1609 dbSNP
rs901871197 1612 dbSNP
rs1200587854 1629 dbSNP
rs1452131430 1630 dbSNP
rs954284054 1631 dbSNP
rs532435181 1637 dbSNP
rs555805758 1639 dbSNP
rs1459528696 1646 dbSNP
rs377617797 1647 dbSNP
rs1029020292 1652 dbSNP
rs957510022 1662 dbSNP
rs1257789507 1663 dbSNP
rs990721423 1666 dbSNP
rs567725957 1672 dbSNP
rs1472480583 1675 dbSNP
rs535143410 1676 dbSNP
rs1020454456 1677 dbSNP
rs1447231185 1681 dbSNP
rs956265114 1690 dbSNP
rs1378761960 1691 dbSNP
rs2514262 1698 dbSNP
rs183159788 1702 dbSNP
rs1409259629 1703 dbSNP
rs1402325314 1708 dbSNP
rs917378975 1710 dbSNP
rs1173796708 1718 dbSNP
rs1403670438 1720 dbSNP
rs949856463 1732 dbSNP
rs1164235903 1737 dbSNP
rs979898895 1741 dbSNP
rs927121590 1742 dbSNP
rs1181751121 1752 dbSNP
rs545370587 1759 dbSNP
rs1443480627 1774 dbSNP
rs930553882 1776 dbSNP
rs369603394 1777 dbSNP
rs1198800930 1779 dbSNP
rs1347504852 1782 dbSNP
rs938979619 1798 dbSNP
rs557279173 1799 dbSNP
rs1355627093 1806 dbSNP
rs200446327 1807 dbSNP
rs886048565 1807 dbSNP
rs916315686 1807 dbSNP
rs1279767073 1808 dbSNP
rs1335694869 1815 dbSNP
rs1049338014 1825 dbSNP
rs886048566 1828 dbSNP
rs1298434877 1835 dbSNP
rs80147679 1836 dbSNP
rs187653511 1837 dbSNP
rs75578020 1844 dbSNP
rs1352471286 1846 dbSNP
rs76463793 1848 dbSNP
rs77451107 1849 dbSNP
rs61889863 1851 dbSNP
rs748450531 1851 dbSNP
rs940589922 1851 dbSNP
rs1370691300 1854 dbSNP
rs759157298 1854 dbSNP
rs886048567 1854 dbSNP
rs1040250624 1856 dbSNP
rs533020503 1856 dbSNP
rs542972940 1856 dbSNP
rs886048568 1856 dbSNP
rs886048569 1857 dbSNP
rs11227798 1858 dbSNP
rs1215804303 1858 dbSNP
rs1269233722 1858 dbSNP
rs1359182878 1858 dbSNP
rs1436702780 1858 dbSNP
rs147580597 1858 dbSNP
rs1491046777 1858 dbSNP
rs373880828 1858 dbSNP
rs397749289 1858 dbSNP
rs886048570 1858 dbSNP
rs35146220 1859 dbSNP
rs886048571 1859 dbSNP
rs1324275484 1860 dbSNP
rs7936733 1860 dbSNP
rs901795950 1862 dbSNP
rs867214951 1874 dbSNP
rs1408286004 1875 dbSNP
rs1359572577 1877 dbSNP
rs886048572 1878 dbSNP
rs1028469561 1884 dbSNP
rs1225305183 1884 dbSNP
rs1273120095 1887 dbSNP
rs1479099319 1888 dbSNP
rs1482894425 1890 dbSNP
rs1183435195 1897 dbSNP
rs889967000 1898 dbSNP
rs1191513591 1912 dbSNP
rs1000441051 1919 dbSNP
rs1234800969 1923 dbSNP
rs1033705447 1927 dbSNP
rs886048573 1934 dbSNP
rs886048574 1940 dbSNP
rs548811817 1943 dbSNP
rs1181533164 1958 dbSNP
rs774271313 1960 dbSNP
rs748296888 1970 dbSNP
rs1271621959 1973 dbSNP
rs971432483 1981 dbSNP
rs1372681972 1982 dbSNP
rs980200763 1985 dbSNP
rs927120262 2001 dbSNP
rs570209950 2005 dbSNP
rs984706658 2013 dbSNP
rs907820710 2019 dbSNP
rs1020840434 2025 dbSNP
rs1428856335 2026 dbSNP
rs541154026 2031 dbSNP
rs1337131032 2044 dbSNP
rs1393491323 2045 dbSNP
rs981628410 2046 dbSNP
rs1039980270 2052 dbSNP
rs1445303897 2055 dbSNP
rs1178903617 2056 dbSNP
rs922941577 2060 dbSNP
rs1382811119 2062 dbSNP
rs1210199603 2063 dbSNP
rs1349673396 2064 dbSNP
rs886048575 2066 dbSNP
rs1247536474 2072 dbSNP
rs771896989 2078 dbSNP
rs1273099034 2079 dbSNP
rs1354902028 2079 dbSNP
rs886048576 2090 dbSNP
rs1196720324 2091 dbSNP
rs1275595520 2093 dbSNP
rs1373246715 2094 dbSNP
rs1441074258 2095 dbSNP
rs780002066 2096 dbSNP
rs886048577 2099 dbSNP
rs990449428 2100 dbSNP
rs916258667 2105 dbSNP
rs1453683057 2108 dbSNP
rs930360560 2109 dbSNP
rs749055593 2120 dbSNP
rs984575860 2121 dbSNP
rs1407143690 2134 dbSNP
rs907642129 2136 dbSNP
rs1000811992 2140 dbSNP
rs1054707443 2141 dbSNP
rs1486369135 2156 dbSNP
rs1186822812 2166 dbSNP
rs1040218186 2168 dbSNP
rs754783722 2168 dbSNP
rs886048578 2168 dbSNP
rs1488398608 2170 dbSNP
rs1262905778 2174 dbSNP
rs892018374 2175 dbSNP
rs541691229 2177 dbSNP
rs1168457171 2179 dbSNP
rs191420904 2187 dbSNP
rs886048579 2188 dbSNP
rs1412559915 2190 dbSNP
rs1292727722 2191 dbSNP
rs1001605836 2195 dbSNP
rs11822066 2196 dbSNP
rs778619168 2199 dbSNP
rs1290471863 2200 dbSNP
rs1406447390 2209 dbSNP
rs554195108 2218 dbSNP
rs1451375551 2238 dbSNP
rs1344315313 2241 dbSNP
rs1165430829 2243 dbSNP
rs985062656 2251 dbSNP
rs1415083068 2253 dbSNP
rs1186562976 2258 dbSNP
rs563532066 2259 dbSNP
rs907705779 2271 dbSNP
rs1202935272 2272 dbSNP
rs374288210 2275 dbSNP
rs975986914 2276 dbSNP
rs370262108 2281 dbSNP
rs1272699455 2283 dbSNP
rs1219309391 2284 dbSNP
rs1328213603 2288 dbSNP
rs1293706832 2291 dbSNP
rs1381822489 2308 dbSNP
rs1228736861 2309 dbSNP
rs1361035191 2309 dbSNP
rs1272448228 2310 dbSNP
rs1462983181 2313 dbSNP
rs886048580 2313 dbSNP
rs1343234970 2314 dbSNP
rs1462057369 2321 dbSNP
rs567682286 2322 dbSNP
rs1003041156 2326 dbSNP
rs1195892641 2326 dbSNP
rs1374258116 2326 dbSNP
rs1487751927 2326 dbSNP
rs796540356 2326 dbSNP
rs1491234059 2327 dbSNP
rs867071753 2327 dbSNP
rs11227799 2328 dbSNP
rs1491392197 2328 dbSNP
rs766971670 2328 dbSNP
rs1219080503 2329 dbSNP
rs886048581 2332 dbSNP
rs1263977322 2333 dbSNP
rs1303963183 2334 dbSNP
rs1035864868 2337 dbSNP
rs958912566 2341 dbSNP
rs1325178955 2343 dbSNP
rs1391851477 2345 dbSNP
rs1210696601 2346 dbSNP
rs1398071677 2347 dbSNP
rs1206871042 2348 dbSNP
rs1247451957 2349 dbSNP
rs1013189959 2353 dbSNP
rs1461232183 2358 dbSNP
rs1395297508 2359 dbSNP
rs1175063787 2363 dbSNP
rs1053498892 2364 dbSNP
rs1023698554 2367 dbSNP
rs893530593 2369 dbSNP
rs747686059 2371 dbSNP
rs1440034299 2387 dbSNP
rs1447676585 2387 dbSNP
rs1248557262 2390 dbSNP
rs951728995 2407 dbSNP
rs1193736891 2412 dbSNP
rs1483733391 2421 dbSNP
rs1282749332 2425 dbSNP
rs1232322091 2428 dbSNP
rs1345500780 2430 dbSNP
rs1374728652 2432 dbSNP
rs886048582 2439 dbSNP
rs537752551 2441 dbSNP
rs931674596 2452 dbSNP
rs1326350722 2468 dbSNP
rs1390325139 2468 dbSNP
rs907608927 2468 dbSNP
rs1429521984 2477 dbSNP
rs1050182062 2496 dbSNP
rs1314362930 2515 dbSNP
rs1432427661 2519 dbSNP
rs925058745 2521 dbSNP
rs1159474773 2526 dbSNP
rs547113573 2529 dbSNP
rs975849365 2530 dbSNP
rs923115136 2540 dbSNP
rs1475596660 2547 dbSNP
rs1318162068 2550 dbSNP
rs1259651976 2551 dbSNP
rs1387207312 2554 dbSNP
rs773336845 2559 dbSNP
rs1320849488 2560 dbSNP
rs1279432302 2562 dbSNP
rs1205493704 2567 dbSNP
rs1054992934 2569 dbSNP
rs1352506878 2577 dbSNP
rs1329920826 2582 dbSNP
rs886048583 2584 dbSNP
rs760698045 2585 dbSNP
rs1238189159 2592 dbSNP
rs1232962361 2598 dbSNP
rs1010462766 2607 dbSNP
rs1284374240 2615 dbSNP
rs1355562307 2619 dbSNP
rs1294565226 2631 dbSNP
rs1412584881 2643 dbSNP
rs1050380137 2646 dbSNP
rs571746418 2651 dbSNP
rs1226748829 2657 dbSNP
rs1402819007 2662 dbSNP
rs1383210811 2663 dbSNP
rs183547972 2666 dbSNP
rs1046041244 2668 dbSNP
rs116414393 2669 dbSNP
rs1475038286 2670 dbSNP
rs1381574407 2672 dbSNP
rs1242931128 2679 dbSNP
rs77828276 2680 dbSNP
rs1034429151 2684 dbSNP
rs903231017 2685 dbSNP
rs952190790 2705 dbSNP
rs1439820677 2707 dbSNP
rs189502443 2710 dbSNP
rs192454438 2717 dbSNP
rs1230907597 2727 dbSNP
rs1481306448 2733 dbSNP
rs1270442778 2745 dbSNP
rs1432397408 2750 dbSNP
rs1325100562 2754 dbSNP
rs185206750 2755 dbSNP
rs894665204 2758 dbSNP
rs961883626 2765 dbSNP
rs1397313319 2771 dbSNP
rs1013525837 2774 dbSNP
rs776602987 2776 dbSNP
rs1027226198 2794 dbSNP
rs1453843793 2801 dbSNP
rs540764381 2812 dbSNP
rs571282792 2827 dbSNP
rs975955850 2830 dbSNP
rs145684543 2837 dbSNP
rs1474534667 2839 dbSNP
rs148932555 2861 dbSNP
rs757176022 2862 dbSNP
rs538665266 2869 dbSNP
rs1386666906 2874 dbSNP
rs1468904373 2875 dbSNP
rs1014545078 2881 dbSNP
rs553567809 2882 dbSNP
rs1320618848 2884 dbSNP
rs764991694 2891 dbSNP
rs924976421 2892 dbSNP
rs961735812 2893 dbSNP
rs545186050 2909 dbSNP
rs563492120 2911 dbSNP
rs1336635971 2913 dbSNP
rs923082417 2915 dbSNP
rs1324503579 2930 dbSNP
rs530806797 2946 dbSNP
rs1440747563 2950 dbSNP
rs953194589 2952 dbSNP
rs936395339 2959 dbSNP
rs549335985 2961 dbSNP
rs190045472 2965 dbSNP
rs1408497704 2980 dbSNP
rs752119317 2986 dbSNP
rs757994378 2993 dbSNP
rs528535037 3002 dbSNP
rs1396609792 3003 dbSNP
rs1191723902 3005 dbSNP
rs546681598 3017 dbSNP
rs1241241180 3023 dbSNP
rs1233020808 3026 dbSNP
rs946221027 3027 dbSNP
rs1263794917 3030 dbSNP
rs571674945 3044 dbSNP
rs1221585424 3056 dbSNP
rs907485637 3059 dbSNP
rs1234523721 3062 dbSNP
rs947296179 3065 dbSNP
rs1219196506 3072 dbSNP
rs1301671759 3072 dbSNP
rs1374680508 3080 dbSNP
rs1041687054 3084 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions TZM-bl
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM1462574. RNA binding protein: AGO2. Condition:TZM-bl ami BaL ...

- Whisnant AW; Bogerd HP; Flores O; Ho P; et al., 2013, mBio.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' guGUGAGUACACCGGGGGUCGu 5'
            ||| ||| ||  ||||||| 
Target 5' caCAC-CAU-UGCACCCCAGCc 3'
 		3 - 22
Article - Whisnant AW; Bogerd HP; Flores O; Ho P; et al.
- mBio, 2013
UNLABELLED: The question of how HIV-1 interfaces with cellular microRNA (miRNA) biogenesis and effector mechanisms has been highly controversial. Here, we first used deep sequencing of small RNAs present in two different infected cell lines (TZM-bl and C8166) and two types of primary human cells (CD4(+) peripheral blood mononuclear cells [PBMCs] and macrophages) to unequivocally demonstrate that HIV-1 does not encode any viral miRNAs. Perhaps surprisingly, we also observed that infection of T cells by HIV-1 has only a modest effect on the expression of cellular miRNAs at early times after infection. Comprehensive analysis of miRNA binding to the HIV-1 genome using the photoactivatable ribonucleoside-induced cross-linking and immunoprecipitation (PAR-CLIP) technique revealed several binding sites for cellular miRNAs, a subset of which were shown to be capable of mediating miRNA-mediated repression of gene expression. However, the main finding from this analysis is that HIV-1 transcripts are largely refractory to miRNA binding, most probably due to extensive viral RNA secondary structure. Together, these data demonstrate that HIV-1 neither encodes viral miRNAs nor strongly influences cellular miRNA expression, at least early after infection, and imply that HIV-1 transcripts have evolved to avoid inhibition by preexisting cellular miRNAs by adopting extensive RNA secondary structures that occlude most potential miRNA binding sites. IMPORTANCE: MicroRNAs (miRNAs) are a ubiquitous class of small regulatory RNAs that serve as posttranscriptional regulators of gene expression. Previous work has suggested that HIV-1 might subvert the function of the cellular miRNA machinery by expressing viral miRNAs or by dramatically altering the level of cellular miRNA expression. Using very sensitive approaches, we now demonstrate that neither of these ideas is in fact correct. Moreover, HIV-1 transcripts appear to largely avoid regulation by cellular miRNAs by adopting an extensive RNA secondary structure that occludes the ability of cellular miRNAs to interact with viral mRNAs. Together, these data suggest that HIV-1, rather than seeking to control miRNA function in infected cells, has instead evolved a mechanism to become largely invisible to cellular miRNA effector mechanisms.
LinkOut: [PMID: 23592263]
CLIP-seq Support 1 for dataset GSM1462574
Method / RBP PAR-CLIP / AGO2
Cell line / Condition TZM-bl / TZM-bl ami BaL
Location of target site ENST00000438189.2 | 3UTR | AUCACACCAUUGCACCCCAGCCUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23592263 / GSE59944
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
321 hsa-miR-4731-5p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT081189 MIDN midnolin 2 4
MIRT113400 RAB5B RAB5B, member RAS oncogene family 2 8
MIRT153789 NCOA3 nuclear receptor coactivator 3 2 2
MIRT169837 GIGYF1 GRB10 interacting GYF protein 1 2 6
MIRT441540 CHD7 chromodomain helicase DNA binding protein 7 2 2
MIRT443470 ACPP acid phosphatase, prostate 2 2
MIRT443851 RGS6 regulator of G protein signaling 6 2 2
MIRT444416 EMC1 ER membrane protein complex subunit 1 2 2
MIRT444838 PDE6D phosphodiesterase 6D 2 2
MIRT444997 HRH1 histamine receptor H1 2 2
MIRT446371 THSD4 thrombospondin type 1 domain containing 4 2 2
MIRT449696 SLC10A3 solute carrier family 10 member 3 2 2
MIRT451068 PNMAL2 paraneoplastic Ma antigen family member 8B 2 2
MIRT451915 ILK integrin linked kinase 2 2
MIRT452990 CABP4 calcium binding protein 4 2 2
MIRT458034 MRPL12 mitochondrial ribosomal protein L12 2 2
MIRT460780 VPS37B VPS37B, ESCRT-I subunit 2 2
MIRT463916 WNT3 Wnt family member 3 2 2
MIRT465880 TMEM43 transmembrane protein 43 2 4
MIRT466317 THRA thyroid hormone receptor, alpha 2 2
MIRT468696 SEC22C SEC22 homolog C, vesicle trafficking protein 2 4
MIRT469129 RNF126 ring finger protein 126 2 2
MIRT472239 NFIC nuclear factor I C 2 2
MIRT479647 CD4 CD4 molecule 2 2
MIRT479734 CCND1 cyclin D1 2 6
MIRT479837 CCDC86 coiled-coil domain containing 86 2 2
MIRT483408 SPATA6 spermatogenesis associated 6 2 4
MIRT485972 RTBDN retbindin 2 2
MIRT486614 METTL6 methyltransferase like 6 2 2
MIRT487814 PER3 period circadian clock 3 2 2
MIRT488586 ST7L suppression of tumorigenicity 7 like 2 2
MIRT488673 WWP2 WW domain containing E3 ubiquitin protein ligase 2 2 2
MIRT490783 PSMD3 proteasome 26S subunit, non-ATPase 3 2 2
MIRT491356 PEX6 peroxisomal biogenesis factor 6 2 2
MIRT493539 IGDCC3 immunoglobulin superfamily DCC subclass member 3 2 4
MIRT493894 FAM43A family with sequence similarity 43 member A 2 4
MIRT494664 ARL8A ADP ribosylation factor like GTPase 8A 2 2
MIRT506353 NUP50 nucleoporin 50 2 6
MIRT508553 CEP72 centrosomal protein 72 2 4
MIRT508722 ZNF682 zinc finger protein 682 2 4
MIRT508811 GPR155 G protein-coupled receptor 155 2 2
MIRT509070 MED18 mediator complex subunit 18 2 2
MIRT509107 BMP8B bone morphogenetic protein 8b 2 6
MIRT509198 TTF2 transcription termination factor 2 2 2
MIRT509308 ZNF460 zinc finger protein 460 2 2
MIRT509341 ZNF708 zinc finger protein 708 2 2
MIRT509381 ASH2L ASH2 like histone lysine methyltransferase complex subunit 2 6
MIRT509722 EFCAB11 EF-hand calcium binding domain 11 2 4
MIRT510008 CRISPLD2 cysteine rich secretory protein LCCL domain containing 2 2 4
MIRT510067 C12orf49 chromosome 12 open reading frame 49 2 6
MIRT510179 BCL2L2 BCL2 like 2 2 2
MIRT511300 KIAA1551 KIAA1551 2 2
MIRT511531 HMGB1 high mobility group box 1 2 6
MIRT512018 DNAJC10 DnaJ heat shock protein family (Hsp40) member C10 2 2
MIRT514112 SERF2 small EDRK-rich factor 2 2 2
MIRT514296 FXYD5 FXYD domain containing ion transport regulator 5 2 6
MIRT514460 FANCA Fanconi anemia complementation group A 2 2
MIRT515183 CRCP CGRP receptor component 2 2
MIRT515290 C4orf3 chromosome 4 open reading frame 3 2 2
MIRT515528 QRFPR pyroglutamylated RFamide peptide receptor 2 4
MIRT515553 TMEM134 transmembrane protein 134 2 2
MIRT515619 ISY1 ISY1 splicing factor homolog 2 2
MIRT515707 ZNF321P zinc finger protein 321, pseudogene 2 2
MIRT515988 SLC30A2 solute carrier family 30 member 2 2 2
MIRT516179 POLR3A RNA polymerase III subunit A 2 4
MIRT516247 BCAS4 breast carcinoma amplified sequence 4 2 4
MIRT516505 SYTL3 synaptotagmin like 3 2 4
MIRT516586 SPHAR S-phase response (cyclin related) 2 2
MIRT516697 ODF2L outer dense fiber of sperm tails 2 like 2 2
MIRT516779 PTRF caveolae associated protein 1 2 4
MIRT516998 COX19 COX19, cytochrome c oxidase assembly factor 2 2
MIRT517094 CCDC30 coiled-coil domain containing 30 2 4
MIRT517163 SLC28A1 solute carrier family 28 member 1 2 2
MIRT517234 PRIM1 DNA primase subunit 1 2 4
MIRT517602 SAV1 salvador family WW domain containing protein 1 2 2
MIRT517631 ZNF491 zinc finger protein 491 2 2
MIRT517734 C1orf220 chromosome 1 open reading frame 220 2 2
MIRT517748 DIS3L DIS3 like exosome 3'-5' exoribonuclease 2 4
MIRT518005 RPL4 ribosomal protein L4 2 4
MIRT518184 SLC27A4 solute carrier family 27 member 4 2 2
MIRT518266 LEAP2 liver enriched antimicrobial peptide 2 2 2
MIRT518448 KIF6 kinesin family member 6 2 2
MIRT518679 KCNMB1 potassium calcium-activated channel subfamily M regulatory beta subunit 1 2 2
MIRT518834 NEK8 NIMA related kinase 8 2 2
MIRT519142 C2orf49 chromosome 2 open reading frame 49 2 2
MIRT519250 PLA2G12A phospholipase A2 group XIIA 2 2
MIRT519369 RBM28 RNA binding motif protein 28 2 2
MIRT519410 KCNA7 potassium voltage-gated channel subfamily A member 7 2 4
MIRT519495 MAPK13 mitogen-activated protein kinase 13 2 2
MIRT520061 YIPF4 Yip1 domain family member 4 2 2
MIRT520132 WSB1 WD repeat and SOCS box containing 1 2 2
MIRT520289 UBXN2A UBX domain protein 2A 2 2
MIRT520433 TTLL12 tubulin tyrosine ligase like 12 2 2
MIRT520553 TNRC6B trinucleotide repeat containing 6B 2 2
MIRT520764 TCF23 transcription factor 23 2 2
MIRT520806 TAOK1 TAO kinase 1 2 2
MIRT520874 STX17 syntaxin 17 2 2
MIRT520986 SOCS5 suppressor of cytokine signaling 5 2 2
MIRT521077 SLC25A15 solute carrier family 25 member 15 2 2
MIRT521165 SDHAF1 succinate dehydrogenase complex assembly factor 1 2 2
MIRT521213 SBNO1 strawberry notch homolog 1 2 2
MIRT521485 RAB4A RAB4A, member RAS oncogene family 2 2
MIRT521638 PROSC pyridoxal phosphate binding protein 2 2
MIRT522151 NR2F6 nuclear receptor subfamily 2 group F member 6 2 4
MIRT522300 NKAP NFKB activating protein 2 2
MIRT522445 MOB4 MOB family member 4, phocein 2 2
MIRT522493 MFN1 mitofusin 1 2 2
MIRT522877 KHSRP KH-type splicing regulatory protein 2 2
MIRT523059 HYPK huntingtin interacting protein K 2 2
MIRT523095 HSPE1-MOB4 HSPE1-MOB4 readthrough 2 2
MIRT523577 GGA2 golgi associated, gamma adaptin ear containing, ARF binding protein 2 2 2
MIRT523634 FOXK1 forkhead box K1 2 4
MIRT524231 DCTN6 dynactin subunit 6 2 2
MIRT524266 CYCS cytochrome c, somatic 2 2
MIRT524367 CREB1 cAMP responsive element binding protein 1 2 2
MIRT524430 CNKSR3 CNKSR family member 3 2 2
MIRT524557 CASP16 caspase 16, pseudogene 2 2
MIRT524585 CALCOCO2 calcium binding and coiled-coil domain 2 2 2
MIRT524955 AGO3 argonaute 3, RISC catalytic component 2 2
MIRT531856 MAP2K2 mitogen-activated protein kinase kinase 2 2 2
MIRT541995 MYO1C myosin IC 2 2
MIRT542247 HSPA4L heat shock protein family A (Hsp70) member 4 like 2 2
MIRT542601 YOD1 YOD1 deubiquitinase 2 2
MIRT545238 ZFAND3 zinc finger AN1-type containing 3 2 2
MIRT552183 F2RL3 F2R like thrombin or trypsin receptor 3 2 2
MIRT553520 TMEM245 transmembrane protein 245 2 2
MIRT554430 SAMD8 sterile alpha motif domain containing 8 2 2
MIRT559138 BTF3L4 basic transcription factor 3 like 4 2 4
MIRT564062 CDT1 chromatin licensing and DNA replication factor 1 2 2
MIRT564857 ZBED3 zinc finger BED-type containing 3 2 2
MIRT565382 TGOLN2 trans-golgi network protein 2 2 2
MIRT568952 RUNX3 runt related transcription factor 3 2 2
MIRT568983 CACNA1C calcium voltage-gated channel subunit alpha1 C 2 2
MIRT569255 FAM129B family with sequence similarity 129 member B 2 2
MIRT570199 RAP1GAP2 RAP1 GTPase activating protein 2 2 2
MIRT570913 PPFIA4 PTPRF interacting protein alpha 4 2 2
MIRT571084 ZNF670 zinc finger protein 670 2 2
MIRT571456 YKT6 YKT6 v-SNARE homolog 2 2
MIRT574233 DMRT2 doublesex and mab-3 related transcription factor 2 2 2
MIRT608730 MYH9 myosin heavy chain 9 2 2
MIRT610109 IL17REL interleukin 17 receptor E like 2 2
MIRT614235 WDR53 WD repeat domain 53 2 4
MIRT626199 PNRC1 proline rich nuclear receptor coactivator 1 2 4
MIRT626325 LRTOMT leucine rich transmembrane and O-methyltransferase domain containing 2 2
MIRT626381 BBS1 Bardet-Biedl syndrome 1 2 2
MIRT627164 ZNF48 zinc finger protein 48 2 2
MIRT633098 CBX5 chromobox 5 2 2
MIRT642246 PAK4 p21 (RAC1) activated kinase 4 2 2
MIRT643882 IMP4 IMP4, U3 small nucleolar ribonucleoprotein 2 2
MIRT644837 SEC14L4 SEC14 like lipid binding 4 2 2
MIRT645189 POLR3F RNA polymerase III subunit F 2 4
MIRT645781 FFAR4 free fatty acid receptor 4 2 2
MIRT647144 CYP27C1 cytochrome P450 family 27 subfamily C member 1 2 2
MIRT647273 CHST6 carbohydrate sulfotransferase 6 2 2
MIRT648743 FAM46B family with sequence similarity 46 member B 2 2
MIRT649204 KIAA1715 lunapark, ER junction formation factor 2 2
MIRT649859 WDR12 WD repeat domain 12 2 2
MIRT650814 PNPLA3 patatin like phospholipase domain containing 3 2 2
MIRT659537 CHCHD5 coiled-coil-helix-coiled-coil-helix domain containing 5 2 2
MIRT664212 LSM3 LSM3 homolog, U6 small nuclear RNA and mRNA degradation associated 2 2
MIRT664373 CYB5A cytochrome b5 type A 2 2
MIRT667395 MOB1B MOB kinase activator 1B 2 2
MIRT669465 ATL3 atlastin GTPase 3 2 2
MIRT670556 SHISA2 shisa family member 2 2 2
MIRT673104 MFSD2A major facilitator superfamily domain containing 2A 2 2
MIRT679350 LRG1 leucine rich alpha-2-glycoprotein 1 2 2
MIRT680354 GATAD1 GATA zinc finger domain containing 1 2 4
MIRT680680 ZNF785 zinc finger protein 785 2 2
MIRT680759 WDR73 WD repeat domain 73 2 2
MIRT681392 RMND1 required for meiotic nuclear division 1 homolog 2 2
MIRT681687 ABI2 abl interactor 2 2 2
MIRT681817 N4BP2L2 NEDD4 binding protein 2 like 2 2 2
MIRT682314 RAB42 RAB42, member RAS oncogene family 2 2
MIRT683308 C19orf40 Fanconi anemia core complex associated protein 24 1 1
MIRT683374 ESR2 estrogen receptor 2 2 2
MIRT683466 CCS copper chaperone for superoxide dismutase 2 2
MIRT683481 ZNF7 zinc finger protein 7 2 2
MIRT683514 C11orf54 chromosome 11 open reading frame 54 2 2
MIRT683860 OCIAD1 OCIA domain containing 1 2 2
MIRT683926 SLC43A3 solute carrier family 43 member 3 2 2
MIRT683935 MYLK3 myosin light chain kinase 3 2 2
MIRT684068 TLR7 toll like receptor 7 2 2
MIRT684120 CEP104 centrosomal protein 104 2 2
MIRT684192 MSRB2 methionine sulfoxide reductase B2 2 2
MIRT684343 IFIT3 interferon induced protein with tetratricopeptide repeats 3 2 2
MIRT684480 GPR137B G protein-coupled receptor 137B 2 2
MIRT684565 ORAI2 ORAI calcium release-activated calcium modulator 2 2 2
MIRT684608 GTF2IRD2B GTF2I repeat domain containing 2B 2 2
MIRT684643 PDE4C phosphodiesterase 4C 2 2
MIRT684700 LRRD1 leucine rich repeats and death domain containing 1 2 2
MIRT684735 DNAJB13 DnaJ heat shock protein family (Hsp40) member B13 2 2
MIRT684911 CD28 CD28 molecule 2 2
MIRT685024 MRI1 methylthioribose-1-phosphate isomerase 1 2 2
MIRT685186 DCTN5 dynactin subunit 5 2 2
MIRT685234 F2RL1 F2R like trypsin receptor 1 2 2
MIRT685303 ASB16 ankyrin repeat and SOCS box containing 16 2 2
MIRT685345 CCL5 C-C motif chemokine ligand 5 2 2
MIRT685553 TXK TXK tyrosine kinase 2 2
MIRT685570 KCNK6 potassium two pore domain channel subfamily K member 6 2 2
MIRT685651 C11orf1 chromosome 11 open reading frame 1 2 2
MIRT685697 BHMT2 betaine--homocysteine S-methyltransferase 2 2 2
MIRT685731 C12orf65 chromosome 12 open reading frame 65 2 2
MIRT685873 RTN2 reticulon 2 2 2
MIRT685937 PTGIS prostaglandin I2 synthase 2 2
MIRT686095 TNIP3 TNFAIP3 interacting protein 3 2 2
MIRT686147 HS3ST1 heparan sulfate-glucosamine 3-sulfotransferase 1 2 2
MIRT686271 WWC1 WW and C2 domain containing 1 2 2
MIRT686307 VPS53 VPS53, GARP complex subunit 2 2
MIRT686349 USP15 ubiquitin specific peptidase 15 2 2
MIRT686377 UBE2V2 ubiquitin conjugating enzyme E2 V2 2 2
MIRT686431 LINC00598 long intergenic non-protein coding RNA 598 2 2
MIRT686477 TRIOBP TRIO and F-actin binding protein 2 2
MIRT686515 TRAF3IP2 TRAF3 interacting protein 2 2 2
MIRT686682 TIMM10 translocase of inner mitochondrial membrane 10 2 2
MIRT686818 SLC7A11 solute carrier family 7 member 11 2 2
MIRT686904 SGTB small glutamine rich tetratricopeptide repeat containing beta 2 2
MIRT686974 SERINC1 serine incorporator 1 2 2
MIRT687035 RNF115 ring finger protein 115 2 2
MIRT687067 RABGAP1L RAB GTPase activating protein 1 like 2 2
MIRT687240 PDHB pyruvate dehydrogenase E1 beta subunit 2 2
MIRT687494 NFATC2IP nuclear factor of activated T-cells 2 interacting protein 2 2
MIRT687591 MANEAL mannosidase endo-alpha like 2 2
MIRT687635 LRIF1 ligand dependent nuclear receptor interacting factor 1 2 2
MIRT687673 LMBR1L limb development membrane protein 1 like 2 2
MIRT687849 ISCA2 iron-sulfur cluster assembly 2 2 2
MIRT687918 HOOK3 hook microtubule tethering protein 3 2 2
MIRT687974 GTF2IRD2 GTF2I repeat domain containing 2 2 2
MIRT688105 GK5 glycerol kinase 5 (putative) 2 2
MIRT688115 GEMIN8 gem nuclear organelle associated protein 8 2 2
MIRT688148 GABPB1 GA binding protein transcription factor beta subunit 1 2 2
MIRT688263 FAM213A family with sequence similarity 213 member A 2 2
MIRT688456 DNAJB4 DnaJ heat shock protein family (Hsp40) member B4 2 2
MIRT688497 DDI2 DNA damage inducible 1 homolog 2 2 2
MIRT688558 DCAF16 DDB1 and CUL4 associated factor 16 2 2
MIRT688668 CPT1A carnitine palmitoyltransferase 1A 2 2
MIRT689057 AGMAT agmatinase 2 2
MIRT689075 ADO 2-aminoethanethiol dioxygenase 2 2
MIRT689108 ZBTB25 zinc finger and BTB domain containing 25 2 2
MIRT689161 ZNF665 zinc finger protein 665 2 2
MIRT689788 GTF2H3 general transcription factor IIH subunit 3 2 2
MIRT689835 HIST1H2BJ histone cluster 1 H2B family member j 2 2
MIRT690061 MBD1 methyl-CpG binding domain protein 1 2 2
MIRT690727 IRAK4 interleukin 1 receptor associated kinase 4 2 2
MIRT690974 ZNF578 zinc finger protein 578 2 2
MIRT691066 NUGGC nuclear GTPase, germinal center associated 2 2
MIRT691315 KIAA1841 KIAA1841 2 2
MIRT691485 FOXRED2 FAD dependent oxidoreductase domain containing 2 2 2
MIRT691568 CCDC125 coiled-coil domain containing 125 2 2
MIRT691601 IPP intracisternal A particle-promoted polypeptide 2 2
MIRT692059 ACOT9 acyl-CoA thioesterase 9 2 2
MIRT692099 CXorf38 chromosome X open reading frame 38 2 4
MIRT692311 RFK riboflavin kinase 2 2
MIRT692371 LY6G5B lymphocyte antigen 6 family member G5B 2 2
MIRT692432 METTL8 methyltransferase like 8 2 2
MIRT692468 APEX2 apurinic/apyrimidinic endodeoxyribonuclease 2 2 2
MIRT692532 PARD3 par-3 family cell polarity regulator 2 2
MIRT692594 GDF5OS growth differentiation factor 5 opposite strand 2 2
MIRT692776 SYNPO2L synaptopodin 2 like 2 2
MIRT692810 C1orf50 chromosome 1 open reading frame 50 2 2
MIRT692868 RBM41 RNA binding motif protein 41 2 2
MIRT693131 THEM4 thioesterase superfamily member 4 2 2
MIRT693313 TRIM58 tripartite motif containing 58 2 2
MIRT693497 MOB3A MOB kinase activator 3A 2 2
MIRT694101 ZNF446 zinc finger protein 446 2 2
MIRT694173 POLM DNA polymerase mu 2 2
MIRT694186 ZNF347 zinc finger protein 347 2 2
MIRT694444 TNFAIP8L1 TNF alpha induced protein 8 like 1 2 2
MIRT694653 C14orf119 chromosome 14 open reading frame 119 2 2
MIRT694802 STX4 syntaxin 4 2 2
MIRT694922 ANKS4B ankyrin repeat and sterile alpha motif domain containing 4B 2 2
MIRT695174 SLC25A33 solute carrier family 25 member 33 2 2
MIRT695305 PIGO phosphatidylinositol glycan anchor biosynthesis class O 2 4
MIRT695656 MAN2B2 mannosidase alpha class 2B member 2 2 2
MIRT695823 ABCG8 ATP binding cassette subfamily G member 8 2 2
MIRT695964 EIF2B2 eukaryotic translation initiation factor 2B subunit beta 2 2
MIRT696174 GNB5 G protein subunit beta 5 2 2
MIRT696433 SUGP1 SURP and G-patch domain containing 1 2 2
MIRT696610 CRIPT CXXC repeat containing interactor of PDZ3 domain 2 2
MIRT696854 UBOX5 U-box domain containing 5 2 2
MIRT696896 C14orf105 coiled-coil domain containing 198 2 2
MIRT697382 ZMAT3 zinc finger matrin-type 3 2 2
MIRT697529 ZBTB46 zinc finger and BTB domain containing 46 2 2
MIRT697973 TSPAN6 tetraspanin 6 2 2
MIRT698325 TMEM127 transmembrane protein 127 2 2
MIRT698915 SPEM1 spermatid maturation 1 2 2
MIRT699257 SLC6A4 solute carrier family 6 member 4 2 2
MIRT699311 SLC35F5 solute carrier family 35 member F5 2 4
MIRT699624 SH3BP5 SH3 domain binding protein 5 2 2
MIRT699688 SF3B3 splicing factor 3b subunit 3 2 2
MIRT700040 RPL14 ribosomal protein L14 2 2
MIRT700095 RNF19B ring finger protein 19B 2 2
MIRT700498 PTPN4 protein tyrosine phosphatase, non-receptor type 4 2 2
MIRT700747 PLAA phospholipase A2 activating protein 2 2
MIRT701103 PAPD5 poly(A) RNA polymerase D5, non-canonical 2 2
MIRT701568 MYPN myopalladin 2 2
MIRT701692 MYADM myeloid associated differentiation marker 2 2
MIRT701815 MRPL37 mitochondrial ribosomal protein L37 2 2
MIRT702435 KIAA1549 KIAA1549 2 2
MIRT702518 KCND3 potassium voltage-gated channel subfamily D member 3 2 2
MIRT702954 HIP1 huntingtin interacting protein 1 2 2
MIRT703079 GPRIN3 GPRIN family member 3 2 2
MIRT704106 DRAXIN dorsal inhibitory axon guidance protein 2 2
MIRT704138 DNAL1 dynein axonemal light chain 1 2 2
MIRT704187 LDHD lactate dehydrogenase D 2 2
MIRT704754 CDKN2AIPNL CDKN2A interacting protein N-terminal like 2 2
MIRT705075 C4orf29 abhydrolase domain containing 18 2 2
MIRT705342 ATP1B3 ATPase Na+/K+ transporting subunit beta 3 2 2
MIRT706274 SLC35F6 solute carrier family 35 member F6 2 2
MIRT706397 HAS2 hyaluronan synthase 2 2 2
MIRT706431 LIAS lipoic acid synthetase 2 2
MIRT706506 MTMR9 myotubularin related protein 9 2 2
MIRT707586 PCNXL2 pecanex homolog 2 2 2
MIRT708361 CDIPT CDP-diacylglycerol--inositol 3-phosphatidyltransferase 2 2
MIRT708444 MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5 2 2
MIRT709915 GRIK3 glutamate ionotropic receptor kainate type subunit 3 2 2
MIRT712607 BHLHA15 basic helix-loop-helix family member a15 2 2
MIRT716540 GOLGA2 golgin A2 2 2
MIRT721623 VDR vitamin D receptor 2 2
MIRT724887 MVK mevalonate kinase 2 2
MIRT725257 PARVB parvin beta 2 2
MIRT755885 RPLP0 ribosomal protein lateral stalk subunit P0 3 1
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-4731 Fluorouracil 3385 NSC19893 approved sensitive High Pancreatic Cancer cell line (PANC-1)
hsa-mir-4731 Gemcitabine 60750 NSC613327 approved sensitive High Pancreatic Cancer cell line (PANC-1)
hsa-mir-4731 Cisplatin 5460033 NSC119875 approved sensitive cell line (A2780)
hsa-miR-4731-5p Anthracycline 30323 NSC82151 approved resistant High Breast Cancer tissue
hsa-miR-4731-5p Fluorouracil 3385 NSC19893 approved resistant High Breast Cancer tissue
hsa-miR-4731-5p Cyclophosphamide 2907 NSC26271 approved resistant High Breast Cancer tissue
hsa-miR-4731-5p Methotrexate 126941 NSC740 approved resistant High Breast Cancer tissue
hsa-miR-4731-5p Taxol 36314 NSC125973 approved resistant High Breast Cancer tissue
hsa-miR-4731-5p Vemurafenib 42611257 NSC761431 approved resistant cell line (451Lu)
hsa-miR-4731-5p Gemcitabine 60750 NSC613327 approved sensitive cell line (PANC-1) (100 ng/ml)
hsa-miR-4731-5p Gemcitabine 60750 NSC613327 approved sensitive cell line (PANC-1) (1500 ng/ml)

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