miRTarBase - #MIRT453048


—
pre-miRNA Information
pre-miRNA hsa-mir-203b   
Genomic Coordinates chr14: 104117418 - 104117503
Description Homo sapiens miR-203b stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-203b-3p
Sequence 54| UUGAACUGUUAAGAACCACUGGA |76
Evidence Experimental
Experiments Illumina
Editing Events in miRNAs
Modification Type Position on miR Chromosome DNA Strand Genomic Position (hg38) List of PMIDs Variant details
A-to-I 11 14 - 104117440 28550310 MiREDiBase
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1444131167 3 dbSNP
rs1307766631 8 dbSNP
rs527418519 12 dbSNP
rs771545143 20 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol TANGO2   
Synonyms C22orf25, MECRCN
Description transport and golgi organization 2 homolog
Transcript NM_152906   
Expression
Putative miRNA Targets on TANGO2
3'UTR of TANGO2
(miRNA target sites are highlighted)		 
>TANGO2|NM_152906|3'UTR
   1 CCCCACCTCTGGGCCTGGCCAGTGGGCTCCTGGGGGGCCCTGCCTTGAGGGGCACTGTGGACAGGAAACCTTCCTTTGCC
  81 ATACTGCATTGCACTGCCCGTGGCTTGGCCAGCATCCCCCGGATCAGGGCCCTGTGGTTTGCGTGTTACCCATCTGTGTC
 161 CCCATGCCCAGTTCAGGGTCTGCCTTTATGCCAGTGAGGAGCAGCAGAGTCTGATACTAGGTCTAGGACCGGCCGAGGTA
 241 TACCATGAACATGTGGATACACCTGAGCCCACTCTTGCACATGTACACAGGCACTCACATGGCACACACATACACTCCTG
 321 CGTGTGCACAAGCACACACATGCAAGCCATATACATGGACACCGACACAGGCACATGTACGTGCACAGGTGTGCTACACA
 401 TGTGCACACATGCACAGTTGCACAGACACACACACACAGGTGCACACACACGATGCCGAACAAGGCAGAAGGGCGACTCT
 481 CACCTCTCATGTGCTTCTGGCCAGTAGGTCTTTGTTCTGGTCCAACGACAGGAGTAGGCTTGTATTTAAAAGCGGCCCCT
 561 CCTCTCCTGTGGCCACAGAACACAGGCGTGCTTGGACTCTTGACAAGCAGACCTGCTCCTGCAGAGGAGACAGCCACATT
 641 TGGAATTGGGCACCGAGAAGACCTGAGAAAAACCCACTCTCTCTTTTTTTTTTTTTTGAGACGGAGTCTTGCTCTGTCAC
 721 CCAGGCTGGAGTGCAGTGGCACGATCTCGGCTCACTGCAACCTCCGCCTCCCAAGTTCAAGCAATTCTCCTGCCCCAGCC
 801 TCCTGATTAGCTGGGATTACAGGCGTGTGCCACCATGCCCAGCTAATTTTTGTGTTTTTAGTAGAGACGGGGTTTCACCA
 881 TGTTGGTCAGGCTGGTCTTGAACTCCTGACGTGGTGATCCACCTGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGCGTG
 961 AGCCACCACGCCTGGCCGAAAAACCCACTCTCATAACAGAAGTGCAGACTCATTGCTAGATTCAGTGCCCTTGAGTGTGC
1041 CAGAGGTCCTCTGTGTTTGAGACAATCCTGTGTGTGCCAGGAGGCTCCGTGTGCACCAGGGGCTCTCAGAATCCCGCTTA
1121 CCCAGCTGGAGACCATGCCTCTGGCAGCCCCATCTCAGCCAGCCCTGCTCTCTCCCTCTTCCCTCCAGGTGAGGCAAACT
1201 TCATAGGAATCTGTACCTGAATGTGAGCTCCTGATAATAAAACTCTGAGGCTTTGGTGAGCGCATTTCGAGGCCTTTCCC
1281 TTGTATGCAGGGTGCCAGTGGGAGCTGCTATGTCTCCTGTGCAGCCAGACACCCTGGACGAGGCCCTTCCCACCTCCCCC
1361 TTTCCTCACGGCTTCTTCAGCACCACATGTGGATGCCTGTGGGTCAGTCCATCTGTCCATGGGCAGGGGCCGCTGTGAGA
1441 GACCCCATGCGCGTGGGATGTGGTAGATGCTGATTATGGGGCCAGCCACCCATACAGGTCTATCAGGTCGCAATGGAGGC
1521 CCCACTGGAGCGGGAGGCAGGCTGGCCTGGACTTCTGTTGGATGATGGGGGCCAGGGGATGGTAGGAGGGGCAGGAGAGC
1601 AGGTCTGCATCTGTCTCAGCCCCAGGAGCTCCTGGTTTGGGGCCAGCTCTAAGGAGCTTCATCCCTGAGCCTGGCCGAGT
1681 ATAAGGGGGTCCCGGATATCCAATGCTGAGACCTAGACTTTTCTAAGCCTCTGCACCCAACCCCTAACTTGGCCTTTTCA
1761 GACCCATGAGAGTGCAGGGTGGGTGTGGACCTGCGCCAGGGCTTCCCAGCCTGATTGTGACATGATGTGAGTCCACCTAG
1841 GGAGGAGCAGGGGCCTCCCCGTCTCTTCCCCTTCTTGCCCAGACCACTTTGCTGGGCTCAGAGCCTTCCATGGCTCACTT
1921 TGAACTCAGAAGAGTTTCCCAGCTGCGACCCAGGCTGCACCCCCAGGCCTGAGGAGAAACTGAGGCCCCACATCCCATAC
2001 GTGTCCTCTGAGTCAGGACAACAGGCTCCCGGCTGGGGGCACTGCCCTTGCTGCCAACACATTCACCTGCCCCAGTGGCT
2081 ACCATGTCCTGTGCCGGTGACCAGTGCCAGTCCCCAACCTGGATGGTGCCCTGCCCTCATGAAGAGCCCCCCGGATGTTC
2161 ACCTCTGCCCAGAGACCCGGCCTGCCCAGGAAGAGCAGTCTCTGCTCTTGTGTGGGTCCCTCTGCCCCCACCCTGCCCAG
2241 GGCTCCCCAGCAGCCTGAGGCCCCTAAGGAAGAACAGCCCTCAATGGTGATTCTATTGGTGTTATGAGTTGTGTCCCCAA
2321 AGAGATATATCAGTGTCCTGACCCACAGTACCTCAGAATGTGACTGCATTTGGAGATAGGGTTCTTCCAGGGGTAACCAA
2401 GGTAGAATGAGGTCGTTAGTGTGGGCCCTAATCCAATATGACGGCTATCCTTATAAAAAGAGGAACATTTAGGCTGGATA
2481 CAGTGGCTCATGCCTATAATCC
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' aggucaccaagaauuGUCAAGUu 5'
                         ||||||| 
Target 5' ctgtgtccccatgccCAGTTCAg 3'
 154 - 176 140.00 -8.47
2 
miRNA  3' agGU-CACCAA--GA-AUU--GUCAAGUu 5'
            || |||| |  || |::  |||| || 
Target 5' caCATGTGGATGCCTGTGGGTCAGTCCAt 3'
 1384 - 1412 121.00 -12.60
3 
miRNA  3' aggucaccaagaauugUCAAGUu 5'
                          |||||| 
Target 5' caacctccgcctcccaAGTTCAa 3'
 758 - 780 120.00 -7.40
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN29193498 12 COSMIC
COSN28841195 38 COSMIC
COSN30178381 51 COSMIC
COSN30189793 83 COSMIC
COSN6562502 121 COSMIC
COSN29281147 136 COSMIC
COSN18743930 137 COSMIC
COSN31610603 143 COSMIC
COSN28715310 258 COSMIC
COSN28714630 297 COSMIC
COSN28794718 348 COSMIC
COSN23299439 453 COSMIC
COSN8013941 584 COSMIC
COSN8013942 596 COSMIC
COSN29390220 909 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs750008397 2 dbSNP
rs755799964 6 dbSNP
rs1455955117 7 dbSNP
rs201848039 8 dbSNP
rs779369266 10 dbSNP
rs1363321183 15 dbSNP
rs1434983784 21 dbSNP
rs1295938716 24 dbSNP
rs1389571843 25 dbSNP
rs1385428013 30 dbSNP
rs1033944551 32 dbSNP
rs749891667 32 dbSNP
rs767019391 32 dbSNP
rs943422285 37 dbSNP
rs748779459 38 dbSNP
rs754546353 41 dbSNP
rs779360380 42 dbSNP
rs1039104383 44 dbSNP
rs748701728 48 dbSNP
rs772275474 50 dbSNP
rs907815119 56 dbSNP
rs940520089 59 dbSNP
rs1411668504 60 dbSNP
rs1180342891 64 dbSNP
rs1451698137 67 dbSNP
rs1197684734 70 dbSNP
rs973667802 71 dbSNP
rs369685102 81 dbSNP
rs1487849920 86 dbSNP
rs1270906619 91 dbSNP
rs920458253 95 dbSNP
rs1335279529 99 dbSNP
rs1451085483 100 dbSNP
rs932023672 101 dbSNP
rs1337480209 108 dbSNP
rs1329383072 116 dbSNP
rs538409576 117 dbSNP
rs3804045 118 dbSNP
rs183947516 121 dbSNP
rs1052689418 122 dbSNP
rs1391498714 134 dbSNP
rs1386319046 136 dbSNP
rs544274351 143 dbSNP
rs1328476896 144 dbSNP
rs554585789 147 dbSNP
rs1453318402 148 dbSNP
rs1250563181 149 dbSNP
rs1297236923 150 dbSNP
rs1468632322 153 dbSNP
rs1004067581 165 dbSNP
rs771634933 170 dbSNP
rs1363481898 180 dbSNP
rs1057339760 183 dbSNP
rs1248744353 190 dbSNP
rs1232417466 191 dbSNP
rs1266587760 197 dbSNP
rs1368927816 208 dbSNP
rs1356411112 215 dbSNP
rs567042041 231 dbSNP
rs905379430 232 dbSNP
rs1001202853 235 dbSNP
rs17818431 236 dbSNP
rs1287301145 237 dbSNP
rs1172547183 238 dbSNP
rs1465924800 242 dbSNP
rs1433396766 244 dbSNP
rs1392783862 251 dbSNP
rs1194970364 253 dbSNP
rs3804044 258 dbSNP
rs992929547 263 dbSNP
rs1190519670 269 dbSNP
rs1247135015 270 dbSNP
rs559962453 273 dbSNP
rs1014823113 282 dbSNP
rs1022716532 290 dbSNP
rs1345653948 291 dbSNP
rs1282291722 294 dbSNP
rs3804043 297 dbSNP
rs1189490288 299 dbSNP
rs1341483049 300 dbSNP
rs1268687683 306 dbSNP
rs1327456256 308 dbSNP
rs999829667 308 dbSNP
rs1369032132 310 dbSNP
rs1333906885 311 dbSNP
rs1413260938 316 dbSNP
rs1457456731 319 dbSNP
rs546039693 322 dbSNP
rs563236387 323 dbSNP
rs956467881 328 dbSNP
rs973356560 329 dbSNP
rs987673251 336 dbSNP
rs1476189702 338 dbSNP
rs531880310 340 dbSNP
rs1242552228 347 dbSNP
rs415520 348 dbSNP
rs372337416 349 dbSNP
rs36073203 357 dbSNP
rs964890189 364 dbSNP
rs375205325 365 dbSNP
rs1307030901 373 dbSNP
rs1216606693 376 dbSNP
rs931804469 376 dbSNP
rs568130776 377 dbSNP
rs908479704 378 dbSNP
rs1398207670 381 dbSNP
rs912008484 381 dbSNP
rs442277 382 dbSNP
rs1052843004 384 dbSNP
rs1314078206 387 dbSNP
rs9618733 391 dbSNP
rs547874250 393 dbSNP
rs199757713 394 dbSNP
rs1409723444 400 dbSNP
rs895676786 400 dbSNP
rs1326268730 402 dbSNP
rs1411086401 403 dbSNP
rs1419823993 408 dbSNP
rs1340470960 411 dbSNP
rs1012742671 426 dbSNP
rs1188653305 426 dbSNP
rs372265007 426 dbSNP
rs1243262832 442 dbSNP
rs573882408 448 dbSNP
rs892482571 452 dbSNP
rs570818939 458 dbSNP
rs1031315884 459 dbSNP
rs144944431 475 dbSNP
rs1272813563 476 dbSNP
rs1208926978 478 dbSNP
rs1337460883 481 dbSNP
rs1009587080 482 dbSNP
rs1223776831 489 dbSNP
rs558471554 490 dbSNP
rs1371833613 498 dbSNP
rs1019191213 507 dbSNP
rs1443763466 508 dbSNP
rs1354586610 509 dbSNP
rs1463356775 510 dbSNP
rs1324847311 511 dbSNP
rs1043988089 523 dbSNP
rs536544913 527 dbSNP
rs747434211 528 dbSNP
rs965281802 539 dbSNP
rs1418223180 540 dbSNP
rs1405743157 549 dbSNP
rs1002359187 554 dbSNP
rs1470582816 555 dbSNP
rs71312731 562 dbSNP
rs1252422263 569 dbSNP
rs1212132212 571 dbSNP
rs538118946 572 dbSNP
rs974848708 577 dbSNP
rs1215555097 586 dbSNP
rs1315449496 588 dbSNP
rs1224793683 589 dbSNP
rs1377082395 595 dbSNP
rs367450 598 dbSNP
rs367451 600 dbSNP
rs1372731351 601 dbSNP
rs983486776 611 dbSNP
rs375151739 616 dbSNP
rs1452820927 619 dbSNP
rs907902050 620 dbSNP
rs1423104178 625 dbSNP
rs1161255199 644 dbSNP
rs866821768 647 dbSNP
rs1185345908 650 dbSNP
rs939362278 655 dbSNP
rs540186783 656 dbSNP
rs1472977177 664 dbSNP
rs912973639 677 dbSNP
rs917138170 677 dbSNP
rs553839592 680 dbSNP
rs1054213 682 dbSNP
rs1253887380 682 dbSNP
rs1186122504 684 dbSNP
rs1244188072 684 dbSNP
rs948564335 684 dbSNP
rs1347805911 686 dbSNP
rs576855008 694 dbSNP
rs1467898912 697 dbSNP
rs75034587 699 dbSNP
rs1401963111 700 dbSNP
rs1394754038 701 dbSNP
rs1301604128 703 dbSNP
rs1381276424 704 dbSNP
rs1310424324 729 dbSNP
rs1359689479 730 dbSNP
rs1290402467 731 dbSNP
rs1351769150 732 dbSNP
rs1400324028 734 dbSNP
rs1014974066 739 dbSNP
rs1287304646 743 dbSNP
rs1326715481 744 dbSNP
rs1378240193 745 dbSNP
rs1234964106 749 dbSNP
rs1256309928 750 dbSNP
rs935767835 758 dbSNP
rs1482817078 762 dbSNP
rs1198620553 763 dbSNP
rs1253939139 765 dbSNP
rs546422674 766 dbSNP
rs376593924 767 dbSNP
rs1486393775 776 dbSNP
rs1052836939 779 dbSNP
rs1226320095 784 dbSNP
rs11555966 785 dbSNP
rs1305405054 788 dbSNP
rs1297199972 789 dbSNP
rs995123524 790 dbSNP
rs1438114095 795 dbSNP
rs762110942 797 dbSNP
rs1027607771 807 dbSNP
rs12170347 811 dbSNP
rs891495262 821 dbSNP
rs140840130 825 dbSNP
rs985987292 826 dbSNP
rs1403090662 827 dbSNP
rs1297687018 835 dbSNP
rs1019623911 841 dbSNP
rs1475108112 846 dbSNP
rs911747341 863 dbSNP
rs576195529 865 dbSNP
rs372884504 869 dbSNP
rs1190769252 870 dbSNP
rs1475816662 874 dbSNP
rs988252542 881 dbSNP
rs528653126 889 dbSNP
rs1479341422 895 dbSNP
rs1252748774 911 dbSNP
rs913854656 912 dbSNP
rs542138871 918 dbSNP
rs952196426 920 dbSNP
rs1464896320 923 dbSNP
rs1310362499 926 dbSNP
rs188383488 926 dbSNP
rs1234835599 928 dbSNP
rs1371781800 931 dbSNP
rs1306141690 938 dbSNP
rs983537377 940 dbSNP
rs1014999814 941 dbSNP
rs1332354379 947 dbSNP
rs946780086 949 dbSNP
rs1043946410 954 dbSNP
rs527689380 956 dbSNP
rs926904016 959 dbSNP
rs938161492 963 dbSNP
rs1301582247 964 dbSNP
rs11555967 970 dbSNP
rs896670898 971 dbSNP
rs925801980 978 dbSNP
rs1014385961 979 dbSNP
rs1467758764 984 dbSNP
rs1036115213 985 dbSNP
rs1270820882 988 dbSNP
rs763101528 989 dbSNP
rs766482139 991 dbSNP
rs897480763 993 dbSNP
rs1249648472 1000 dbSNP
rs1236765186 1013 dbSNP
rs935817818 1017 dbSNP
rs994541650 1020 dbSNP
rs1310071561 1023 dbSNP
rs1440173191 1026 dbSNP
rs548689735 1027 dbSNP
rs1027555163 1029 dbSNP
rs1052890805 1031 dbSNP
rs891511165 1037 dbSNP
rs1191957477 1043 dbSNP
rs1384677831 1046 dbSNP
rs1157400903 1047 dbSNP
rs944374650 1054 dbSNP
rs1040009838 1062 dbSNP
rs900153389 1064 dbSNP
rs575726225 1071 dbSNP
rs953253793 1077 dbSNP
rs1027857125 1082 dbSNP
rs192712234 1084 dbSNP
rs1004972021 1089 dbSNP
rs759478824 1090 dbSNP
rs533248563 1098 dbSNP
rs1429613421 1102 dbSNP
rs1233685312 1104 dbSNP
rs1345761600 1116 dbSNP
rs1305942512 1117 dbSNP
rs1437445622 1122 dbSNP
rs1326281778 1127 dbSNP
rs1167291703 1135 dbSNP
rs1384221087 1136 dbSNP
rs1361762658 1138 dbSNP
rs1018756886 1140 dbSNP
rs1433606289 1145 dbSNP
rs767429797 1176 dbSNP
rs1392699184 1177 dbSNP
rs1352222430 1180 dbSNP
rs552385489 1182 dbSNP
rs752383165 1184 dbSNP
rs737984 1186 dbSNP
rs1190771402 1203 dbSNP
rs988631478 1205 dbSNP
rs1263848927 1206 dbSNP
rs914021361 1213 dbSNP
rs1484767555 1218 dbSNP
rs1293731033 1222 dbSNP
rs1280826041 1224 dbSNP
rs1491392177 1234 dbSNP
rs1491365941 1235 dbSNP
rs755818497 1237 dbSNP
rs960800344 1239 dbSNP
rs968438274 1245 dbSNP
rs1438266018 1262 dbSNP
rs569086200 1263 dbSNP
rs573741407 1264 dbSNP
rs184343943 1269 dbSNP
rs566988188 1270 dbSNP
rs373033073 1273 dbSNP
rs1414483194 1286 dbSNP
rs763618725 1289 dbSNP
rs1323555711 1290 dbSNP
rs925854288 1293 dbSNP
rs1424040693 1298 dbSNP
rs957201979 1303 dbSNP
rs1464851318 1309 dbSNP
rs143146219 1311 dbSNP
rs1239074386 1319 dbSNP
rs918038765 1320 dbSNP
rs544644486 1322 dbSNP
rs751712653 1325 dbSNP
rs1271198260 1328 dbSNP
rs912984660 1338 dbSNP
rs189236159 1340 dbSNP
rs553484230 1341 dbSNP
rs930399045 1344 dbSNP
rs377750741 1351 dbSNP
rs576898710 1352 dbSNP
rs1406596713 1353 dbSNP
rs539175459 1354 dbSNP
rs1348807629 1358 dbSNP
rs1334625525 1359 dbSNP
rs1459502073 1360 dbSNP
rs1054215 1370 dbSNP
rs1018914539 1380 dbSNP
rs9618734 1381 dbSNP
rs1400494851 1382 dbSNP
rs1163967248 1390 dbSNP
rs115561292 1396 dbSNP
rs541979994 1412 dbSNP
rs1469736275 1431 dbSNP
rs780607659 1432 dbSNP
rs1021437065 1433 dbSNP
rs182325603 1449 dbSNP
rs1381337304 1451 dbSNP
rs530364799 1452 dbSNP
rs541445940 1453 dbSNP
rs564310609 1454 dbSNP
rs1210781395 1458 dbSNP
rs959367882 1459 dbSNP
rs752844881 1473 dbSNP
rs1306465004 1475 dbSNP
rs1032933629 1477 dbSNP
rs1377214533 1486 dbSNP
rs114493347 1488 dbSNP
rs1239584427 1489 dbSNP
rs918208480 1494 dbSNP
rs755421869 1497 dbSNP
rs940166363 1499 dbSNP
rs972902918 1500 dbSNP
rs1165467941 1505 dbSNP
rs1400037463 1507 dbSNP
rs920102178 1508 dbSNP
rs989120216 1510 dbSNP
rs1473378536 1511 dbSNP
rs930346669 1522 dbSNP
rs781637058 1523 dbSNP
rs1048847283 1525 dbSNP
rs1412392166 1531 dbSNP
rs146764529 1532 dbSNP
rs1215437061 1538 dbSNP
rs140428038 1545 dbSNP
rs931651655 1546 dbSNP
rs1048685876 1552 dbSNP
rs1353763874 1553 dbSNP
rs560523033 1554 dbSNP
rs1315884925 1555 dbSNP
rs531542679 1557 dbSNP
rs1448609631 1558 dbSNP
rs1302226507 1561 dbSNP
rs1353612564 1564 dbSNP
rs778571231 1565 dbSNP
rs1429693756 1566 dbSNP
rs1009914455 1576 dbSNP
rs1299915480 1577 dbSNP
rs1020755635 1583 dbSNP
rs1289206382 1596 dbSNP
rs371287679 1598 dbSNP
rs1394532196 1599 dbSNP
rs695412 1602 dbSNP
rs1172066588 1607 dbSNP
rs1435120274 1621 dbSNP
rs1222294594 1622 dbSNP
rs1186324104 1630 dbSNP
rs1281106775 1645 dbSNP
rs1000864865 1652 dbSNP
rs1217963569 1656 dbSNP
rs185028201 1677 dbSNP
rs112111834 1678 dbSNP
rs959358455 1686 dbSNP
rs992144321 1694 dbSNP
rs551076199 1695 dbSNP
rs76235646 1702 dbSNP
rs973404390 1709 dbSNP
rs1338110955 1710 dbSNP
rs1000888770 1715 dbSNP
rs758342474 1719 dbSNP
rs1400515797 1726 dbSNP
rs1412077238 1741 dbSNP
rs1301185208 1745 dbSNP
rs1467609295 1763 dbSNP
rs1469259941 1768 dbSNP
rs920068918 1771 dbSNP
rs892452751 1779 dbSNP
rs570375901 1782 dbSNP
rs1195120619 1787 dbSNP
rs1475171324 1787 dbSNP
rs771137909 1792 dbSNP
rs539373511 1795 dbSNP
rs1010191281 1796 dbSNP
rs1256267528 1801 dbSNP
rs1020611283 1807 dbSNP
rs5993905 1810 dbSNP
rs1315894102 1814 dbSNP
rs984533164 1815 dbSNP
rs774511982 1831 dbSNP
rs942995779 1832 dbSNP
rs1218940727 1840 dbSNP
rs976280312 1846 dbSNP
rs1373622656 1852 dbSNP
rs1028717566 1856 dbSNP
rs1379962875 1861 dbSNP
rs1397906700 1861 dbSNP
rs1040013211 1862 dbSNP
rs984494364 1863 dbSNP
rs779914346 1865 dbSNP
rs922940966 1869 dbSNP
rs1198342896 1870 dbSNP
rs908907251 1871 dbSNP
rs940348632 1875 dbSNP
rs759566649 1885 dbSNP
rs1461206157 1897 dbSNP
rs1367265402 1898 dbSNP
rs1190183634 1900 dbSNP
rs972377209 1909 dbSNP
rs918132206 1912 dbSNP
rs945278213 1927 dbSNP
rs949584374 1932 dbSNP
rs1456172348 1935 dbSNP
rs375828833 1939 dbSNP
rs12158045 1947 dbSNP
rs1440240243 1948 dbSNP
rs1276869837 1950 dbSNP
rs1333847810 1952 dbSNP
rs1263667515 1956 dbSNP
rs148036669 1965 dbSNP
rs903692839 1967 dbSNP
rs1346121013 1969 dbSNP
rs1246882386 1972 dbSNP
rs1322475044 1977 dbSNP
rs1306394017 1980 dbSNP
rs905292235 1983 dbSNP
rs140805111 1987 dbSNP
rs555520989 1988 dbSNP
rs572735435 1989 dbSNP
rs1332247675 1992 dbSNP
rs73389755 1993 dbSNP
rs895211698 2001 dbSNP
rs558399283 2002 dbSNP
rs1458859403 2007 dbSNP
rs1436756310 2016 dbSNP
rs34919729 2024 dbSNP
rs397868014 2024 dbSNP
rs747741074 2029 dbSNP
rs1157538963 2032 dbSNP
rs901733367 2035 dbSNP
rs1239665818 2041 dbSNP
rs1478226805 2044 dbSNP
rs1192847801 2051 dbSNP
rs1024942225 2052 dbSNP
rs1450882729 2055 dbSNP
rs961679438 2059 dbSNP
rs997371726 2065 dbSNP
rs775392355 2067 dbSNP
rs994429013 2074 dbSNP
rs1027685600 2085 dbSNP
rs952846519 2087 dbSNP
rs984545292 2092 dbSNP
rs770258582 2096 dbSNP
rs911410181 2097 dbSNP
rs1325943262 2111 dbSNP
rs796440786 2127 dbSNP
rs1384917485 2129 dbSNP
rs976244003 2134 dbSNP
rs760369084 2139 dbSNP
rs763869425 2144 dbSNP
rs1417380704 2147 dbSNP
rs189067375 2147 dbSNP
rs542759692 2148 dbSNP
rs1042299616 2149 dbSNP
rs925231974 2153 dbSNP
rs949640870 2154 dbSNP
rs695759 2168 dbSNP
rs1229742566 2170 dbSNP
rs1200764642 2174 dbSNP
rs150231785 2177 dbSNP
rs1338159030 2179 dbSNP
rs1193634930 2180 dbSNP
rs1054855981 2189 dbSNP
rs867450485 2194 dbSNP
rs926816023 2196 dbSNP
rs894991194 2199 dbSNP
rs936813933 2203 dbSNP
rs1013633078 2204 dbSNP
rs695369 2205 dbSNP
rs1046957585 2208 dbSNP
rs529401728 2211 dbSNP
rs897148423 2213 dbSNP
rs753488221 2216 dbSNP
rs1361659495 2221 dbSNP
rs1027224005 2223 dbSNP
rs1250863592 2226 dbSNP
rs756840021 2230 dbSNP
rs1189110717 2233 dbSNP
rs1007158995 2236 dbSNP
rs1173936952 2242 dbSNP
rs1478261015 2244 dbSNP
rs1372489277 2246 dbSNP
rs1191501920 2250 dbSNP
rs1474463523 2263 dbSNP
rs1018418520 2266 dbSNP
rs1165005180 2268 dbSNP
rs1263735409 2270 dbSNP
rs57497163 2274 dbSNP
rs1440729966 2281 dbSNP
rs975852538 2283 dbSNP
rs1281057293 2289 dbSNP
rs1201238856 2293 dbSNP
rs74938744 2296 dbSNP
rs749887645 2299 dbSNP
rs9618735 2306 dbSNP
rs60598731 2323 dbSNP
rs1015973047 2326 dbSNP
rs962078930 2333 dbSNP
rs1293172861 2336 dbSNP
rs978185184 2349 dbSNP
rs993193153 2357 dbSNP
rs1414678333 2361 dbSNP
rs1399007037 2364 dbSNP
rs1025091922 2365 dbSNP
rs1466945061 2381 dbSNP
rs1424282355 2382 dbSNP
rs1162567211 2393 dbSNP
rs924963020 2400 dbSNP
rs1471886376 2402 dbSNP
rs1239283888 2403 dbSNP
rs1421685173 2410 dbSNP
rs547378209 2411 dbSNP
rs936558539 2413 dbSNP
rs781521335 2415 dbSNP
rs1247633062 2416 dbSNP
rs1319002635 2423 dbSNP
rs1289849004 2441 dbSNP
rs534150401 2442 dbSNP
rs181734874 2443 dbSNP
rs113161120 2444 dbSNP
rs1212648012 2473 dbSNP
rs1285453138 2484 dbSNP
rs1270934813 2488 dbSNP
rs1448045410 2490 dbSNP
rs1466075053 2497 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions TZM-bl
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM1462574. RNA binding protein: AGO2. Condition:TZM-bl ami BaL ...

- Whisnant AW; Bogerd HP; Flores O; Ho P; et al., 2013, mBio.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' aggucaccaagaauugUCAAGUu 5'
                          |||||| 
Target 5' ---------ccucccaAGUUCAa 3'
 		1 - 14
Article - Whisnant AW; Bogerd HP; Flores O; Ho P; et al.
- mBio, 2013
UNLABELLED: The question of how HIV-1 interfaces with cellular microRNA (miRNA) biogenesis and effector mechanisms has been highly controversial. Here, we first used deep sequencing of small RNAs present in two different infected cell lines (TZM-bl and C8166) and two types of primary human cells (CD4(+) peripheral blood mononuclear cells [PBMCs] and macrophages) to unequivocally demonstrate that HIV-1 does not encode any viral miRNAs. Perhaps surprisingly, we also observed that infection of T cells by HIV-1 has only a modest effect on the expression of cellular miRNAs at early times after infection. Comprehensive analysis of miRNA binding to the HIV-1 genome using the photoactivatable ribonucleoside-induced cross-linking and immunoprecipitation (PAR-CLIP) technique revealed several binding sites for cellular miRNAs, a subset of which were shown to be capable of mediating miRNA-mediated repression of gene expression. However, the main finding from this analysis is that HIV-1 transcripts are largely refractory to miRNA binding, most probably due to extensive viral RNA secondary structure. Together, these data demonstrate that HIV-1 neither encodes viral miRNAs nor strongly influences cellular miRNA expression, at least early after infection, and imply that HIV-1 transcripts have evolved to avoid inhibition by preexisting cellular miRNAs by adopting extensive RNA secondary structures that occlude most potential miRNA binding sites. IMPORTANCE: MicroRNAs (miRNAs) are a ubiquitous class of small regulatory RNAs that serve as posttranscriptional regulators of gene expression. Previous work has suggested that HIV-1 might subvert the function of the cellular miRNA machinery by expressing viral miRNAs or by dramatically altering the level of cellular miRNA expression. Using very sensitive approaches, we now demonstrate that neither of these ideas is in fact correct. Moreover, HIV-1 transcripts appear to largely avoid regulation by cellular miRNAs by adopting an extensive RNA secondary structure that occludes the ability of cellular miRNAs to interact with viral mRNAs. Together, these data suggest that HIV-1, rather than seeking to control miRNA function in infected cells, has instead evolved a mechanism to become largely invisible to cellular miRNA effector mechanisms.
LinkOut: [PMID: 23592263]
CLIP-seq Support 1 for dataset GSM1462574
Method / RBP PAR-CLIP / AGO2
Cell line / Condition TZM-bl / TZM-bl ami BaL
Location of target site ENST00000434570.2 | 3UTR | CCUCCCAAGUUCAAGCAAUUCUCCUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23592263 / GSE59944
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
154 hsa-miR-203b-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT063500 SKI SKI proto-oncogene 2 4
MIRT149737 LDLR low density lipoprotein receptor 2 6
MIRT206557 SOCS5 suppressor of cytokine signaling 5 2 8
MIRT248820 SESN2 sestrin 2 2 2
MIRT261314 SHOC2 SHOC2, leucine rich repeat scaffold protein 2 2
MIRT443290 TAF8 TATA-box binding protein associated factor 8 2 4
MIRT443893 NUDT3 nudix hydrolase 3 2 4
MIRT444057 SERPINA4 serpin family A member 4 2 2
MIRT444345 KIAA1211 KIAA1211 2 2
MIRT444538 AGAP9 ArfGAP with GTPase domain, ankyrin repeat and PH domain 9 2 2
MIRT444594 TGFA transforming growth factor alpha 2 2
MIRT445601 SEC14L3 SEC14 like lipid binding 3 2 2
MIRT446025 PNKD paroxysmal nonkinesigenic dyskinesia 2 2
MIRT446309 TBC1D8B TBC1 domain family member 8B 2 2
MIRT446492 TMEM215 transmembrane protein 215 2 4
MIRT446728 SLC36A4 solute carrier family 36 member 4 2 2
MIRT447468 CISD2 CDGSH iron sulfur domain 2 2 2
MIRT447504 MRPS5 mitochondrial ribosomal protein S5 2 2
MIRT447597 MRPL3 mitochondrial ribosomal protein L3 2 2
MIRT447636 AGPS alkylglycerone phosphate synthase 2 2
MIRT447846 ZRANB2 zinc finger RANBP2-type containing 2 2 2
MIRT448098 TCN2 transcobalamin 2 2 2
MIRT448111 SEMA4G semaphorin 4G 2 2
MIRT448903 CLCN6 chloride voltage-gated channel 6 2 4
MIRT449396 TOX4 TOX high mobility group box family member 4 2 2
MIRT449484 CACNA2D4 calcium voltage-gated channel auxiliary subunit alpha2delta 4 2 2
MIRT450705 RNF152 ring finger protein 152 2 2
MIRT450781 PAPOLG poly(A) polymerase gamma 2 2
MIRT452856 LAX1 lymphocyte transmembrane adaptor 1 2 2
MIRT453048 TANGO2 transport and golgi organization 2 homolog 2 2
MIRT459389 MPLKIP M-phase specific PLK1 interacting protein 2 2
MIRT461156 SLC11A2 solute carrier family 11 member 2 2 4
MIRT461613 PTCD3 pentatricopeptide repeat domain 3 2 2
MIRT463711 YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon 2 8
MIRT464107 VPS35 VPS35, retromer complex component 2 2
MIRT466438 TFAM transcription factor A, mitochondrial 2 2
MIRT467735 SLC36A1 solute carrier family 36 member 1 2 2
MIRT469512 RBFOX2 RNA binding protein, fox-1 homolog 2 2 6
MIRT470026 PTP4A1 protein tyrosine phosphatase type IVA, member 1 2 2
MIRT473411 MDM4 MDM4, p53 regulator 2 2
MIRT480545 BZW1 basic leucine zipper and W2 domains 1 2 2
MIRT488444 ACBD3 acyl-CoA binding domain containing 3 2 2
MIRT489498 CRLF3 cytokine receptor like factor 3 2 4
MIRT496149 RPS15A ribosomal protein S15a 2 2
MIRT497013 PRDM2 PR/SET domain 2 2 2
MIRT497087 PHF12 PHD finger protein 12 2 2
MIRT508695 MTRNR2L4 MT-RNR2-like 4 2 4
MIRT517468 PEX26 peroxisomal biogenesis factor 26 2 2
MIRT525329 CNGB1 cyclic nucleotide gated channel beta 1 2 2
MIRT527842 RDH11 retinol dehydrogenase 11 (all-trans/9-cis/11-cis) 2 2
MIRT529111 AQPEP laeverin 1 1
MIRT530163 C11orf44 chromosome 11 open reading frame 44 2 4
MIRT532249 TBPL2 TATA-box binding protein like 2 2 2
MIRT532828 ZNF704 zinc finger protein 704 2 2
MIRT533140 WNT10A Wnt family member 10A 2 2
MIRT536481 KIAA1468 KIAA1468 2 2
MIRT536802 HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 2 2
MIRT537301 FRS2 fibroblast growth factor receptor substrate 2 2 2
MIRT542650 TAF1D TATA-box binding protein associated factor, RNA polymerase I subunit D 2 2
MIRT545691 NUTF2 nuclear transport factor 2 2 2
MIRT546960 PRR14L proline rich 14 like 2 2
MIRT560566 ZNF460 zinc finger protein 460 2 2
MIRT561792 PAWR pro-apoptotic WT1 regulator 2 2
MIRT562372 ERI2 ERI1 exoribonuclease family member 2 2 2
MIRT569292 SURF6 surfeit 6 2 2
MIRT574090 VASN vasorin 2 2
MIRT619787 HLCS holocarboxylase synthetase 2 2
MIRT620104 HARBI1 harbinger transposase derived 1 2 2
MIRT626003 ZNF517 zinc finger protein 517 2 2
MIRT626375 BBS1 Bardet-Biedl syndrome 1 2 2
MIRT626615 SLC30A6 solute carrier family 30 member 6 2 2
MIRT628381 CACNB2 calcium voltage-gated channel auxiliary subunit beta 2 2 2
MIRT629299 PTPLAD2 3-hydroxyacyl-CoA dehydratase 4 1 1
MIRT630439 IDE insulin degrading enzyme 2 2
MIRT631848 PIGG phosphatidylinositol glycan anchor biosynthesis class G 2 2
MIRT633171 AGO3 argonaute 3, RISC catalytic component 2 2
MIRT633472 ZNF724P zinc finger protein 724 2 2
MIRT634389 PLSCR1 phospholipid scramblase 1 2 2
MIRT635536 TRIM72 tripartite motif containing 72 2 2
MIRT635818 OPA3 OPA3, outer mitochondrial membrane lipid metabolism regulator 2 2
MIRT636165 TIMM8A translocase of inner mitochondrial membrane 8A 2 2
MIRT636792 CYB5D1 cytochrome b5 domain containing 1 2 2
MIRT637946 IVD isovaleryl-CoA dehydrogenase 2 2
MIRT640317 STAT1 signal transducer and activator of transcription 1 2 2
MIRT645131 HES2 hes family bHLH transcription factor 2 2 2
MIRT645658 ADK adenosine kinase 2 2
MIRT646143 FLVCR1 feline leukemia virus subgroup C cellular receptor 1 2 2
MIRT646999 NCR3LG1 natural killer cell cytotoxicity receptor 3 ligand 1 2 2
MIRT648183 C2orf68 chromosome 2 open reading frame 68 2 2
MIRT650085 TERF2 telomeric repeat binding factor 2 2 2
MIRT650326 RTN2 reticulon 2 2 2
MIRT651562 WHSC1L1 nuclear receptor binding SET domain protein 3 2 2
MIRT659367 CREG2 cellular repressor of E1A stimulated genes 2 2 2
MIRT659830 CARHSP1 calcium regulated heat stable protein 1 2 2
MIRT662103 LACTB lactamase beta 2 4
MIRT664837 HUS1 HUS1 checkpoint clamp component 2 2
MIRT669750 ZNF101 zinc finger protein 101 2 4
MIRT669791 GAN gigaxonin 2 2
MIRT670044 RPP14 ribonuclease P/MRP subunit p14 2 2
MIRT670293 RBBP4 RB binding protein 4, chromatin remodeling factor 2 2
MIRT670382 EMP2 epithelial membrane protein 2 2 2
MIRT670950 UGGT1 UDP-glucose glycoprotein glucosyltransferase 1 2 4
MIRT672854 C22orf29 retrotransposon Gag like 10 2 2
MIRT672885 FXN frataxin 2 2
MIRT673994 KCNN3 potassium calcium-activated channel subfamily N member 3 2 2
MIRT674155 BLOC1S3 biogenesis of lysosomal organelles complex 1 subunit 3 2 2
MIRT674495 TIRAP TIR domain containing adaptor protein 2 2
MIRT675461 NUBPL nucleotide binding protein like 2 2
MIRT675669 TMOD2 tropomodulin 2 2 2
MIRT675994 CRKL CRK like proto-oncogene, adaptor protein 2 2
MIRT676069 TIMM50 translocase of inner mitochondrial membrane 50 2 2
MIRT676378 SEC24D SEC24 homolog D, COPII coat complex component 2 2
MIRT676759 SNX2 sorting nexin 2 2 2
MIRT676893 GABPB1 GA binding protein transcription factor beta subunit 1 2 2
MIRT676973 ZNF708 zinc finger protein 708 2 2
MIRT677229 C15orf40 chromosome 15 open reading frame 40 2 2
MIRT677363 HSPA4L heat shock protein family A (Hsp70) member 4 like 2 2
MIRT677456 PDLIM3 PDZ and LIM domain 3 2 2
MIRT678073 EIF2A eukaryotic translation initiation factor 2A 2 2
MIRT678091 ATCAY ATCAY, caytaxin 2 2
MIRT678316 FBLIM1 filamin binding LIM protein 1 2 2
MIRT678411 ANKRD36 ankyrin repeat domain 36 2 2
MIRT678519 ZNF347 zinc finger protein 347 2 2
MIRT678695 TRIP11 thyroid hormone receptor interactor 11 2 2
MIRT678821 PDE6A phosphodiesterase 6A 2 2
MIRT679984 RUNDC1 RUN domain containing 1 2 2
MIRT680608 KIAA0391 KIAA0391 2 2
MIRT680724 PRICKLE1 prickle planar cell polarity protein 1 2 2
MIRT681238 ZNF383 zinc finger protein 383 2 2
MIRT681932 SLC19A3 solute carrier family 19 member 3 2 2
MIRT682003 ATP5S ATP synthase, H+ transporting, mitochondrial Fo complex subunit s (factor B) 2 2
MIRT682500 HERPUD1 homocysteine inducible ER protein with ubiquitin like domain 1 2 2
MIRT685460 CACNG8 calcium voltage-gated channel auxiliary subunit gamma 8 2 2
MIRT688193 FNIP1 folliculin interacting protein 1 2 2
MIRT689666 RBM23 RNA binding motif protein 23 2 2
MIRT691058 CRCP CGRP receptor component 2 2
MIRT691442 CXorf36 chromosome X open reading frame 36 2 2
MIRT695998 DNAJC10 DnaJ heat shock protein family (Hsp40) member C10 2 2
MIRT696395 CORO7 coronin 7 2 2
MIRT702334 KLHL7 kelch like family member 7 2 2
MIRT702555 KBTBD6 kelch repeat and BTB domain containing 6 2 2
MIRT703362 GAPVD1 GTPase activating protein and VPS9 domains 1 2 2
MIRT703551 FKBP14 FK506 binding protein 14 2 2
MIRT705029 CACUL1 CDK2 associated cullin domain 1 2 2
MIRT706335 STAC2 SH3 and cysteine rich domain 2 2 2
MIRT708907 TM4SF19 transmembrane 4 L six family member 19 2 2
MIRT711625 CORO1C coronin 1C 2 2
MIRT714444 TOPAZ1 testis and ovary specific PAZ domain containing 1 2 2
MIRT716324 POU5F1 POU class 5 homeobox 1 2 2
MIRT718568 SLC25A22 solute carrier family 25 member 22 2 2
MIRT720299 DDHD1 DDHD domain containing 1 2 2
MIRT721449 AGPAT6 glycerol-3-phosphate acyltransferase 4 2 2
MIRT723529 NFATC2IP nuclear factor of activated T-cells 2 interacting protein 2 2
MIRT724492 BFAR bifunctional apoptosis regulator 2 2
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-203b Perfluorooctane sulfonate NULL 74483 Microarray zebrafish embryos 20878907 2011 down-regulated
miR-203b 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) NULL 15625 Microarray embryos 22921993 2012 down-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-203b-3p Gemcitabine 60750 NSC613327 approved resistant High Pancreatic Cancer cell line (AsPC-1)
hsa-miR-203b-3p Fluorouracil 3385 NSC19893 approved sensitive High Colorectal Cancer cell line (HCT-116)
hsa-miR-203b-3p Gefitinib 123631 NSC715055 approved sensitive cell line (PC9)
hsa-miR-203b-3p Tamoxifen+Fulvestrant sensitive cell line (LCC9)
hsa-miR-203b-3p Tamoxifen 2733525 NSC180973 approved sensitive cell line (LCC2)
hsa-miR-203b-3p Cisplatin 5460033 NSC119875 approved sensitive cell line (CP20)
hsa-miR-203b-3p Cisplatin 5460033 NSC119875 approved sensitive cell line (CIS)
hsa-miR-203b-3p Osimertinib 71496458 NSC779217 approved sensitive cell line (H1975)
hsa-miR-203b-3p Paclitaxel 36314 NSC125973 approved sensitive cell line (A2780)
hsa-miR-203b-3p Cisplatin 5460033 NSC119875 approved sensitive cell line (A2780)

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