miRTarBase - #MIRT453212


—
pre-miRNA Information
pre-miRNA hsa-mir-4640   
Genomic Coordinates chr6: 30890883 - 30890972
Description Homo sapiens miR-4640 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-4640-5p
Sequence 9| UGGGCCAGGGAGCAGCUGGUGGG |31
Evidence Experimental
Experiments Illumina
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1392105945 7 dbSNP
rs939712790 9 dbSNP
rs762825841 15 dbSNP
rs71552023 20 dbSNP
rs1305909531 21 dbSNP
rs750017220 21 dbSNP
rs1375436057 23 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
Circulating MicroRNA Expression Profiling
Biomarker Information
Biomarker ID Name Type Discovered From Mode Level Source Testing Methods
B32FZJ miR-4640 Safety Biomarker (SAF) Clinical/Experimental Data Expression lower Urine Quantitative polymerase chain reaction
Gene Information
Gene Symbol CERS1   
Synonyms EPM8, LAG1, LASS1, UOG1
Description ceramide synthase 1
Transcript NM_021267   
Other Transcripts NM_198207   
Expression
Putative miRNA Targets on CERS1
3'UTR of CERS1
(miRNA target sites are highlighted)		 
>CERS1|NM_021267|3'UTR
   1 ACCCCTCGGCCCCGCCCCCGTGGACCCGGCCCCACCCCGAATACCCCGGCCACGCTCCCCGTCCTTGGCCGCCCCTCCAC
  81 CCCCTCCAACTCTGCTCCTCTAGGGCCGCCGCCACCTCCCCTGGGACCCCGCCCCCTCATCCTGCCTCCAGTTCCCGGCC
 161 ACGCCCCCCAGGACCCCTGCCCCTCCGGGGACACCGGCCCCGCCCTCAGCCCACTGGTCCCGGGCCGCCGCGGACCCTGC
 241 GCACTCTCTGGTCATCGCCTGGGAGGAAGATGCCACCGCCGCAGCAAGGTCCCTGCGGCCACCACCTCCTCCTCCTCCTG
 321 GCCCTGCTGCTGCCCTCGCTGCCCCTGACCCGCGCCCCCGTGCCCCCAGGCCCAGCCGCCGCCCTGCTCCAGGCTCTAGG
 401 ACTGCGCGATGAGCCCCAGGGTGCCCCCAGGCTCCGGCCGGTTCCCCCGGTCATGTGGCGCCTGTTTCGACGCCGGGACC
 481 CCCAGGAGACCAGGTCTGGCTCGCGGCGGACGTCCCCAGGGGTCACCCTGCAACCGTGCCACGTGGAGGAGCTGGGGGTC
 561 GCCGGAAACATCGTGCGCCACATCCCGGACCGCGGTGCGCCCACCCGGGCCTCGGAGCCTGCCTCGGCCGCGGGGCATTG
 641 CCCTGAGTGGACAGTCGTCTTCGACCTGTCGGCTGTGGAACCCGCTGAGCGCCCGAGCCGGGCCCGCCTGGAGCTGCGTT
 721 TCGCGGCGGCGGCGGCGGCAGCCCCGGAGGGCGGCTGGGAGCTGAGCGTGGCGCAAGCGGGCCAGGGCGCGGGCGCGGAC
 801 CCCGGGCCGGTGCTGCTCCGCCAGTTGGTGCCCGCCCTGGGGCCGCCAGTGCGCGCGGAGCTGCTGGGCGCCGCTTGGGC
 881 TCGCAACGCCTCATGGCCGCGCAGCCTCCGCCTGGCGCTGGCGCTACGCCCCCGGGCCCCTGCCGCCTGCGCGCGCCTGG
 961 CCGAGGCCTCGCTGCTGCTGGTGACCCTCGACCCGCGCCTGTGCCACCCCCTGGCCCGGCCGCGGCGCGACGCCGAACCC
1041 GTGTTGGGCGGCGGCCCCGGGGGCGCTTGTCGCGCGCGGCGGCTGTACGTGAGCTTCCGCGAGGTGGGCTGGCACCGCTG
1121 GGTCATCGCGCCGCGCGGCTTCCTGGCCAACTACTGCCAGGGTCAGTGCGCGCTGCCCGTCGCGCTGTCGGGGTCCGGGG
1201 GGCCGCCGGCGCTCAACCACGCTGTGCTGCGCGCGCTCATGCACGCGGCCGCCCCGGGAGCCGCCGACCTGCCCTGCTGC
1281 GTGCCCGCGCGCCTGTCGCCCATCTCCGTGCTCTTCTTTGACAACAGCGACAACGTGGTGCTGCGGCAGTATGAGGACAT
1361 GGTGGTGGACGAGTGCGGCTGCCGCTAACCCGGGGCGGGCAGGGACGCGGGCCCAACAATAAATGCCGCGTGGTCTGCT
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' ggGUGGUCGACGAG-----GGACCGGGu 5'
            ||||| || |||     |||||||| 
Target 5' gcCACCACCTCCTCCTCCTCCTGGCCCt 3'
 298 - 325 173.00 -31.00
2 
miRNA  3' ggGUGGUCGAC---GAGGGACCGGGu 5'
            |:|| | ||   | ||||||||| 
Target 5' cgCGCCTG-TGCCACCCCCTGGCCCg 3'
 994 - 1018 160.00 -29.60
3 
miRNA  3' ggGUGGU-CGACGAGGGACCGGgu 5'
            |:||: || |||:|||||||  
Target 5' cgCGCCGCGCGGCTTCCTGGCCaa 3'
 1127 - 1150 157.00 -31.30
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
1183736 151 ClinVar
258159 259 ClinVar
1013149 267 ClinVar
1102968 323 ClinVar
258162 324 ClinVar
1053494 343 ClinVar
1100976 347 ClinVar
581534 349 ClinVar
471936 389 ClinVar
930879 406 ClinVar
416263 422 ClinVar
539308 428 ClinVar
665856 454 ClinVar
664346 458 ClinVar
410638 459 ClinVar
861589 465 ClinVar
282357 472 ClinVar
1041827 505 ClinVar
850258 559 ClinVar
1153535 566 ClinVar
137457 614 ClinVar
198776 1173 ClinVar
539307 1179 ClinVar
539306 1191 ClinVar
258160 1214 ClinVar
695263 1218 ClinVar
870880 1228 ClinVar
392938 1232 ClinVar
977094 1241 ClinVar
258161 1249 ClinVar
418231 1262 ClinVar
410640 1265 ClinVar
1101641 1273 ClinVar
837752 1319 ClinVar
1145593 1329 ClinVar
215496 1332 ClinVar
6749 1346 ClinVar
416262 1398 ClinVar
539305 1410 ClinVar
704741 1443 ClinVar
665854 1448 ClinVar
410639 1460 ClinVar
985628 1469 ClinVar
1010796 1510 ClinVar
471937 1519 ClinVar
915273 1529 ClinVar
6747 1542 ClinVar
1107557 1602 ClinVar
1074441 1604 ClinVar
1045015 1628 ClinVar
281627 1641 ClinVar
471938 1649 ClinVar
6748 1661 ClinVar
418232 1663 ClinVar
966764 1673 ClinVar
985271 1676 ClinVar
1001308 1691 ClinVar
539304 1744 ClinVar
1073000 1750 ClinVar
1117643 1764 ClinVar
65389 1771 ClinVar
471939 1773 ClinVar
220404 1786 ClinVar
418233 1813 ClinVar
471940 1846 ClinVar
1031988 1858 ClinVar
959657 1889 ClinVar
705802 1890 ClinVar
659753 1891 ClinVar
705539 1899 ClinVar
1085392 1902 ClinVar
471935 1911 ClinVar
410641 1912 ClinVar
998691 1913 ClinVar
660810 1936 ClinVar
522571 1952 ClinVar
522570 1954 ClinVar
1007022 1963 ClinVar
1078878 1965 ClinVar
COSN30689682 6 COSMIC
COSN30735272 24 COSMIC
COSN30127038 38 COSMIC
COSN31556754 51 COSMIC
COSN20079436 131 COSMIC
COSN30135788 163 COSMIC
COSN30141059 196 COSMIC
COSN30118269 229 COSMIC
COSM6043254 293 COSMIC
COSM7547470 307 COSMIC
COSM5549663 377 COSMIC
COSM7266720 449 COSMIC
COSM8508148 459 COSMIC
COSM5487073 460 COSMIC
COSM4140420 464 COSMIC
COSM9156074 472 COSMIC
COSM8093882 482 COSMIC
COSM7898720 483 COSMIC
COSM8718937 507 COSMIC
COSM9883305 508 COSMIC
COSM8200561 511 COSMIC
COSM7611940 544 COSMIC
COSM9932837 556 COSMIC
COSM5519636 561 COSMIC
COSM9285446 562 COSMIC
COSM5787930 563 COSMIC
COSM3422554 576 COSMIC
COSN30653608 610 COSMIC
COSN30615156 655 COSMIC
COSN28842482 734 COSMIC
COSN27565019 929 COSMIC
COSM7312005 1214 COSMIC
COSM8567869 1287 COSMIC
COSM8607998 1309 COSMIC
COSM4993599 1314 COSMIC
COSM9657610 1315 COSMIC
COSM9505885 1396 COSMIC
COSM9610370 1536 COSMIC
COSM9191814 1543 COSMIC
COSM9482810 1581 COSMIC
COSM7449463 1595 COSMIC
COSM8482694 1610 COSMIC
COSM9643640 1627 COSMIC
COSM6585867 1726 COSMIC
COSM7320600 1746 COSMIC
COSM5626742 1773 COSMIC
COSM1208047 1775 COSMIC
COSM6457603 1782 COSMIC
COSM9141328 1801 COSMIC
COSM3787600 1824 COSMIC
COSM9840172 1843 COSMIC
COSM9840170 1856 COSMIC
COSM6026165 1857 COSMIC
COSM9840168 1858 COSMIC
COSM1391747 1873 COSMIC
COSM7608587 1876 COSMIC
COSM9814290 1880 COSMIC
COSM9191812 1889 COSMIC
COSM8803963 1890 COSMIC
COSM8508708 1898 COSMIC
COSM6200638 1921 COSMIC
COSM9840166 1941 COSMIC
COSM7291782 1949 COSMIC
COSN28884656 1988 COSMIC
COSN28870468 2000 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1192621246 2 dbSNP
rs747125941 7 dbSNP
rs1387908879 10 dbSNP
rs777785062 12 dbSNP
rs1182352655 14 dbSNP
rs908423304 16 dbSNP
rs1252202432 18 dbSNP
rs865943732 27 dbSNP
rs1456781848 28 dbSNP
rs1206907816 29 dbSNP
rs544563624 30 dbSNP
rs752958791 33 dbSNP
rs948203341 34 dbSNP
rs1197811579 38 dbSNP
rs1324052131 39 dbSNP
rs765430003 47 dbSNP
rs755434080 48 dbSNP
rs1385194735 53 dbSNP
rs1229111266 55 dbSNP
rs1156617802 60 dbSNP
rs1471756068 62 dbSNP
rs1047427225 64 dbSNP
rs1254219287 76 dbSNP
rs1320882224 82 dbSNP
rs1465323314 83 dbSNP
rs1183054470 84 dbSNP
rs1485381353 87 dbSNP
rs1254086198 88 dbSNP
rs1249969027 89 dbSNP
rs1446022397 89 dbSNP
rs531212324 91 dbSNP
rs1311836304 96 dbSNP
rs1202717434 98 dbSNP
rs1161783559 104 dbSNP
rs1004954284 108 dbSNP
rs886224872 110 dbSNP
rs1318553664 114 dbSNP
rs919746080 130 dbSNP
rs1302473366 145 dbSNP
rs11667388 151 dbSNP
rs1226370894 156 dbSNP
rs1290021910 163 dbSNP
rs1237312735 164 dbSNP
rs1330848031 167 dbSNP
rs1265626079 168 dbSNP
rs1443640287 170 dbSNP
rs969440487 172 dbSNP
rs1482088606 173 dbSNP
rs918028716 180 dbSNP
rs1413177105 184 dbSNP
rs992138341 185 dbSNP
rs1051940897 190 dbSNP
rs1432153596 193 dbSNP
rs1415089637 195 dbSNP
rs997664790 197 dbSNP
rs1357604470 201 dbSNP
rs1444666375 206 dbSNP
rs1309564918 211 dbSNP
rs1350894110 213 dbSNP
rs1409061381 216 dbSNP
rs1312188232 221 dbSNP
rs900657811 222 dbSNP
rs1274337123 227 dbSNP
rs1448087387 234 dbSNP
rs754080793 236 dbSNP
rs956923667 240 dbSNP
rs1219261545 241 dbSNP
rs1329965974 242 dbSNP
rs1039277212 246 dbSNP
rs1446485477 249 dbSNP
rs947598714 251 dbSNP
rs542969734 257 dbSNP
rs374282355 259 dbSNP
rs1412406282 264 dbSNP
rs1423786669 267 dbSNP
rs1029147591 268 dbSNP
rs1158666470 272 dbSNP
rs1441424796 276 dbSNP
rs1236253450 277 dbSNP
rs1180535407 278 dbSNP
rs1177992163 284 dbSNP
rs1461591525 289 dbSNP
rs1053157981 296 dbSNP
rs996386218 297 dbSNP
rs899577326 298 dbSNP
rs761038780 299 dbSNP
rs1310675843 301 dbSNP
rs934643899 303 dbSNP
rs1240931265 304 dbSNP
rs772809060 307 dbSNP
rs1307695733 308 dbSNP
rs1007855858 309 dbSNP
rs1380267256 310 dbSNP
rs1428829571 310 dbSNP
rs886786707 311 dbSNP
rs1046754957 312 dbSNP
rs767175863 313 dbSNP
rs1358249299 317 dbSNP
rs1318610564 319 dbSNP
rs770147092 320 dbSNP
rs981500523 322 dbSNP
rs1420961005 323 dbSNP
rs370986101 324 dbSNP
rs898455197 326 dbSNP
rs1157966656 332 dbSNP
rs1274881853 333 dbSNP
rs916383400 335 dbSNP
rs774207034 342 dbSNP
rs1179919756 343 dbSNP
rs1482830078 345 dbSNP
rs768421187 347 dbSNP
rs1217699617 350 dbSNP
rs749115084 352 dbSNP
rs775090073 355 dbSNP
rs1239987495 358 dbSNP
rs769796711 359 dbSNP
rs1164935305 360 dbSNP
rs1016588989 362 dbSNP
rs1198788126 363 dbSNP
rs1462539398 364 dbSNP
rs1226932961 368 dbSNP
rs992669308 368 dbSNP
rs745755701 378 dbSNP
rs1278423148 381 dbSNP
rs781079772 391 dbSNP
rs950417647 394 dbSNP
rs758524812 397 dbSNP
rs1458299338 399 dbSNP
rs1189353366 402 dbSNP
rs1351573913 405 dbSNP
rs1162659067 414 dbSNP
rs748219517 415 dbSNP
rs1420703949 417 dbSNP
rs900679184 419 dbSNP
rs1039214872 420 dbSNP
rs1011691382 421 dbSNP
rs1060504782 422 dbSNP
rs368516114 426 dbSNP
rs755093676 428 dbSNP
rs754247769 432 dbSNP
rs756469531 436 dbSNP
rs1267733037 439 dbSNP
rs968287517 440 dbSNP
rs1220079011 441 dbSNP
rs1321489687 444 dbSNP
rs1405807202 445 dbSNP
rs1259112095 446 dbSNP
rs868299849 448 dbSNP
rs1337989821 449 dbSNP
rs751015517 450 dbSNP
rs934696667 454 dbSNP
rs1487660277 458 dbSNP
rs375610429 459 dbSNP
rs1291714515 460 dbSNP
rs1457352642 461 dbSNP
rs371213478 462 dbSNP
rs1172586632 465 dbSNP
rs773933484 468 dbSNP
rs1421717698 471 dbSNP
rs763822282 472 dbSNP
rs762463853 473 dbSNP
rs775390513 475 dbSNP
rs1189916653 477 dbSNP
rs769520095 479 dbSNP
rs1239116792 480 dbSNP
rs746201664 484 dbSNP
rs948744401 486 dbSNP
rs759354984 488 dbSNP
rs1209682490 489 dbSNP
rs776613896 491 dbSNP
rs1313375459 494 dbSNP
rs1288325842 498 dbSNP
rs1337076286 502 dbSNP
rs770784884 503 dbSNP
rs915995518 504 dbSNP
rs748236096 505 dbSNP
rs1333330439 506 dbSNP
rs578136748 511 dbSNP
rs1266267305 519 dbSNP
rs1399346223 519 dbSNP
rs941846448 520 dbSNP
rs1167550163 521 dbSNP
rs558289125 522 dbSNP
rs991984001 523 dbSNP
rs1379381506 524 dbSNP
rs768953358 526 dbSNP
rs983750735 529 dbSNP
rs1239284345 535 dbSNP
rs749512657 536 dbSNP
rs780298709 539 dbSNP
rs756490784 544 dbSNP
rs1200623864 545 dbSNP
rs1484043348 552 dbSNP
rs750814477 553 dbSNP
rs1472990025 555 dbSNP
rs1231850531 557 dbSNP
rs1162472780 559 dbSNP
rs867486870 561 dbSNP
rs201674224 563 dbSNP
rs1311350605 564 dbSNP
rs752526453 565 dbSNP
rs377462104 566 dbSNP
rs1375787373 568 dbSNP
rs1025727382 569 dbSNP
rs1396771162 570 dbSNP
rs751137635 572 dbSNP
rs763476348 573 dbSNP
rs1434156990 575 dbSNP
rs762497401 576 dbSNP
rs752344406 584 dbSNP
rs1438404071 586 dbSNP
rs764931939 591 dbSNP
rs1188718821 592 dbSNP
rs759329060 593 dbSNP
rs778549319 600 dbSNP
rs947865802 605 dbSNP
rs1366529130 608 dbSNP
rs1253618613 609 dbSNP
rs776349995 610 dbSNP
rs146219830 614 dbSNP
rs1287547710 616 dbSNP
rs1056329210 617 dbSNP
rs777027920 617 dbSNP
rs760561747 618 dbSNP
rs1352922645 622 dbSNP
rs773169733 624 dbSNP
rs768665846 625 dbSNP
rs935396919 626 dbSNP
rs1011768739 629 dbSNP
rs1257085738 630 dbSNP
rs1442090666 632 dbSNP
rs771448135 635 dbSNP
rs1415411887 638 dbSNP
rs1290559806 639 dbSNP
rs202000234 641 dbSNP
rs1159811979 642 dbSNP
rs780206023 642 dbSNP
rs1361188280 643 dbSNP
rs1031934941 647 dbSNP
rs946710193 651 dbSNP
rs999479369 652 dbSNP
rs143128504 659 dbSNP
rs907203772 660 dbSNP
rs1402410209 668 dbSNP
rs1395102586 674 dbSNP
rs1332526655 676 dbSNP
rs1352705315 678 dbSNP
rs1451828547 687 dbSNP
rs1045801330 689 dbSNP
rs1249070047 691 dbSNP
rs1327749478 693 dbSNP
rs1235462308 694 dbSNP
rs1193361641 700 dbSNP
rs1344512700 701 dbSNP
rs1198951966 703 dbSNP
rs1254329133 705 dbSNP
rs1449563165 709 dbSNP
rs1182701015 712 dbSNP
rs1250951147 716 dbSNP
rs975011919 723 dbSNP
rs1377699590 726 dbSNP
rs1465162605 738 dbSNP
rs1291562002 739 dbSNP
rs1171346258 744 dbSNP
rs1372074760 749 dbSNP
rs567250770 750 dbSNP
rs140310094 755 dbSNP
rs1307840071 759 dbSNP
rs1371746743 767 dbSNP
rs1389050669 772 dbSNP
rs1301990384 778 dbSNP
rs1019509633 779 dbSNP
rs1277015055 784 dbSNP
rs983675795 784 dbSNP
rs948694568 785 dbSNP
rs951195790 785 dbSNP
rs547179994 788 dbSNP
rs1230545291 790 dbSNP
rs113201419 796 dbSNP
rs1038446117 800 dbSNP
rs1268038365 802 dbSNP
rs1432068605 803 dbSNP
rs1023478790 807 dbSNP
rs1438430307 808 dbSNP
rs570963998 809 dbSNP
rs941894619 815 dbSNP
rs1329640117 817 dbSNP
rs1449721448 826 dbSNP
rs1168290121 831 dbSNP
rs907812940 832 dbSNP
rs983038447 837 dbSNP
rs1294618333 839 dbSNP
rs551084295 841 dbSNP
rs1166754534 843 dbSNP
rs1432217433 849 dbSNP
rs1366145107 853 dbSNP
rs1227945754 861 dbSNP
rs1295757776 864 dbSNP
rs1305534419 866 dbSNP
rs1391299121 868 dbSNP
rs1265926946 874 dbSNP
rs1173467638 875 dbSNP
rs1477241875 876 dbSNP
rs1248747639 879 dbSNP
rs1465018041 884 dbSNP
rs1187536886 890 dbSNP
rs1417022055 891 dbSNP
rs909012453 892 dbSNP
rs1436812229 898 dbSNP
rs1249021073 899 dbSNP
rs1206656210 900 dbSNP
rs1342858323 906 dbSNP
rs531304953 911 dbSNP
rs983399039 914 dbSNP
rs1279522485 926 dbSNP
rs929252008 927 dbSNP
rs1434534960 931 dbSNP
rs562330513 938 dbSNP
rs999401308 942 dbSNP
rs951808051 947 dbSNP
rs1217343729 952 dbSNP
rs1381669632 952 dbSNP
rs1313183329 957 dbSNP
rs1270013355 959 dbSNP
rs1333995690 959 dbSNP
rs1346877527 962 dbSNP
rs1329222149 963 dbSNP
rs1275171584 964 dbSNP
rs902564433 966 dbSNP
rs1027354565 968 dbSNP
rs1239976695 968 dbSNP
rs1043837928 970 dbSNP
rs974895051 971 dbSNP
rs1474467935 973 dbSNP
rs1161983015 977 dbSNP
rs1413402949 979 dbSNP
rs556917672 982 dbSNP
rs946679234 984 dbSNP
rs1449044955 985 dbSNP
rs1411725453 986 dbSNP
rs1354579904 987 dbSNP
rs921943644 988 dbSNP
rs1173567672 989 dbSNP
rs1413201891 990 dbSNP
rs1018439850 991 dbSNP
rs1255108824 991 dbSNP
rs1313529493 991 dbSNP
rs1427718311 992 dbSNP
rs1484881806 996 dbSNP
rs1184834183 997 dbSNP
rs1253115655 1001 dbSNP
rs1039075265 1002 dbSNP
rs1469343680 1005 dbSNP
rs1427358510 1006 dbSNP
rs1415179574 1008 dbSNP
rs1008419623 1020 dbSNP
rs1409298187 1027 dbSNP
rs944947673 1029 dbSNP
rs1483102018 1032 dbSNP
rs1373928795 1033 dbSNP
rs891345288 1037 dbSNP
rs1207964361 1039 dbSNP
rs375438344 1045 dbSNP
rs1350983664 1047 dbSNP
rs543008232 1050 dbSNP
rs1441413863 1051 dbSNP
rs912179229 1054 dbSNP
rs1369077976 1066 dbSNP
rs529560442 1068 dbSNP
rs1222975453 1071 dbSNP
rs867249211 1072 dbSNP
rs1219352666 1073 dbSNP
rs1302196595 1074 dbSNP
rs1345332165 1076 dbSNP
rs1328812419 1080 dbSNP
rs1275812973 1081 dbSNP
rs1437691303 1085 dbSNP
rs975747708 1086 dbSNP
rs186263243 1088 dbSNP
rs1017324676 1089 dbSNP
rs1393460851 1090 dbSNP
rs950914591 1092 dbSNP
rs990276981 1093 dbSNP
rs1351197747 1103 dbSNP
rs1302287824 1105 dbSNP
rs1446499973 1109 dbSNP
rs1361372932 1114 dbSNP
rs957568704 1115 dbSNP
rs1436518858 1118 dbSNP
rs918311000 1124 dbSNP
rs973806207 1126 dbSNP
rs1032216804 1130 dbSNP
rs1023239483 1131 dbSNP
rs1300144901 1136 dbSNP
rs1418366984 1138 dbSNP
rs1384832262 1142 dbSNP
rs1164393829 1145 dbSNP
rs769994620 1148 dbSNP
rs746250122 1150 dbSNP
rs781649981 1151 dbSNP
rs757870806 1155 dbSNP
rs903852214 1157 dbSNP
rs752155951 1158 dbSNP
rs999030522 1160 dbSNP
rs778324698 1161 dbSNP
rs907488748 1162 dbSNP
rs1474940247 1164 dbSNP
rs757906133 1165 dbSNP
rs1290474649 1170 dbSNP
rs4808864 1173 dbSNP
rs1353917040 1174 dbSNP
rs764806804 1175 dbSNP
rs1232853512 1177 dbSNP
rs578219025 1179 dbSNP
rs1280379304 1181 dbSNP
rs1398206733 1183 dbSNP
rs1325991949 1184 dbSNP
rs1324778074 1185 dbSNP
rs747099862 1186 dbSNP
rs1407577669 1188 dbSNP
rs1388953182 1189 dbSNP
rs766202026 1190 dbSNP
rs773079354 1191 dbSNP
rs767483299 1192 dbSNP
rs1168154098 1193 dbSNP
rs1474785640 1194 dbSNP
rs762948218 1197 dbSNP
rs1200844541 1198 dbSNP
rs1449819396 1199 dbSNP
rs775584529 1200 dbSNP
rs558253917 1201 dbSNP
rs746048741 1202 dbSNP
rs1260224428 1203 dbSNP
rs776966639 1205 dbSNP
rs771475316 1206 dbSNP
rs1275526814 1207 dbSNP
rs1439162400 1211 dbSNP
rs1329889481 1212 dbSNP
rs4808863 1214 dbSNP
rs778213666 1215 dbSNP
rs1402976664 1217 dbSNP
rs758878687 1218 dbSNP
rs1409027910 1219 dbSNP
rs747631423 1221 dbSNP
rs778442978 1222 dbSNP
rs1476780696 1223 dbSNP
rs754449715 1225 dbSNP
rs753537451 1226 dbSNP
rs1458924719 1227 dbSNP
rs766003135 1228 dbSNP
rs1057524707 1232 dbSNP
rs755967902 1233 dbSNP
rs1279373441 1234 dbSNP
rs1220982460 1235 dbSNP
rs777905336 1235 dbSNP
rs767371085 1237 dbSNP
rs1303291971 1239 dbSNP
rs900625437 1241 dbSNP
rs761762230 1243 dbSNP
rs1329759247 1244 dbSNP
rs1238991458 1246 dbSNP
rs1440980607 1248 dbSNP
rs181918871 1249 dbSNP
rs1164112656 1259 dbSNP
rs1064793136 1262 dbSNP
rs1335835855 1264 dbSNP
rs944730356 1265 dbSNP
rs912090524 1268 dbSNP
rs1374393967 1269 dbSNP
rs895247220 1272 dbSNP
rs765449212 1273 dbSNP
rs1047993053 1275 dbSNP
rs1378195581 1277 dbSNP
rs1176439271 1281 dbSNP
rs868061973 1282 dbSNP
rs1473026614 1283 dbSNP
rs1352894106 1284 dbSNP
rs929436392 1285 dbSNP
rs759669190 1287 dbSNP
rs1212578292 1290 dbSNP
rs777054909 1291 dbSNP
rs771276786 1292 dbSNP
rs1202390182 1293 dbSNP
rs1279675594 1294 dbSNP
rs747345121 1298 dbSNP
rs1356509629 1302 dbSNP
rs1473546165 1305 dbSNP
rs555453880 1316 dbSNP
rs1181831989 1317 dbSNP
rs920749209 1318 dbSNP
rs1305548087 1319 dbSNP
rs1223559193 1320 dbSNP
rs973565739 1325 dbSNP
rs1285589631 1326 dbSNP
rs773574790 1328 dbSNP
rs1374264843 1329 dbSNP
rs1375718300 1331 dbSNP
rs1311463731 1332 dbSNP
rs571387097 1332 dbSNP
rs758755366 1332 dbSNP
rs775830151 1332 dbSNP
rs1455801094 1335 dbSNP
rs772483004 1335 dbSNP
rs1388538763 1336 dbSNP
rs1421396867 1337 dbSNP
rs1358513119 1338 dbSNP
rs1277943861 1339 dbSNP
rs1188063501 1340 dbSNP
rs1196306302 1344 dbSNP
rs1447624554 1345 dbSNP
rs121434424 1346 dbSNP
rs1416772401 1353 dbSNP
rs1035327337 1354 dbSNP
rs779370447 1356 dbSNP
rs1415775845 1365 dbSNP
rs1280861632 1368 dbSNP
rs1236202209 1378 dbSNP
rs1392409635 1383 dbSNP
rs978050328 1384 dbSNP
rs1296372173 1391 dbSNP
rs1227644911 1392 dbSNP
rs1388551951 1395 dbSNP
rs1324308734 1396 dbSNP
rs1060504781 1398 dbSNP
rs1327700282 1399 dbSNP
rs1474363939 1405 dbSNP
rs1232378665 1407 dbSNP
rs966648207 1410 dbSNP
rs1344026515 1417 dbSNP
rs1227952846 1422 dbSNP
rs1250664858 1425 dbSNP
rs1479628363 1429 dbSNP
rs1256851275 1431 dbSNP
rs1194443998 1433 dbSNP
rs1022132445 1436 dbSNP
rs1489342824 1437 dbSNP
rs1259474229 1438 dbSNP
rs1215790443 1440 dbSNP
rs1467691365 1443 dbSNP
rs1322632787 1444 dbSNP
rs1010776708 1446 dbSNP
rs900553253 1448 dbSNP
rs1429451369 1452 dbSNP
rs1292487411 1455 dbSNP
rs1231020146 1456 dbSNP
rs868026629 1457 dbSNP
rs573559104 1460 dbSNP
rs1278489593 1461 dbSNP
rs1401282711 1462 dbSNP
rs1402117332 1464 dbSNP
rs1359321518 1469 dbSNP
rs1438878646 1480 dbSNP
rs1009289636 1487 dbSNP
rs1362972269 1491 dbSNP
rs1382522321 1492 dbSNP
rs890473382 1495 dbSNP
rs1048221173 1498 dbSNP
rs1246892624 1500 dbSNP
rs1273796772 1502 dbSNP
rs1333497341 1507 dbSNP
rs929541928 1509 dbSNP
rs899464952 1514 dbSNP
rs1288209989 1515 dbSNP
rs1437111227 1517 dbSNP
rs1368993349 1518 dbSNP
rs1037827220 1519 dbSNP
rs1425997323 1520 dbSNP
rs1475836646 1521 dbSNP
rs1374868661 1522 dbSNP
rs1162568437 1526 dbSNP
rs948898162 1526 dbSNP
rs1161508110 1528 dbSNP
rs1345947679 1529 dbSNP
rs1185500767 1536 dbSNP
rs121434422 1542 dbSNP
rs1416440204 1543 dbSNP
rs1293797474 1549 dbSNP
rs1354775883 1551 dbSNP
rs1258108118 1555 dbSNP
rs1285764151 1566 dbSNP
rs1317070715 1567 dbSNP
rs553655225 1572 dbSNP
rs1258652147 1582 dbSNP
rs990604745 1587 dbSNP
rs1481966920 1591 dbSNP
rs1363443064 1594 dbSNP
rs1474517993 1596 dbSNP
rs1184350399 1601 dbSNP
rs1418634806 1604 dbSNP
rs938987727 1604 dbSNP
rs1157162412 1607 dbSNP
rs1436311174 1623 dbSNP
rs927642111 1624 dbSNP
rs1273586395 1626 dbSNP
rs978187037 1627 dbSNP
rs533711419 1628 dbSNP
rs1373416886 1630 dbSNP
rs1171734871 1631 dbSNP
rs1478841372 1632 dbSNP
rs754540207 1640 dbSNP
rs886042202 1641 dbSNP
rs1211988015 1644 dbSNP
rs1280087615 1645 dbSNP
rs1484930393 1647 dbSNP
rs748789973 1650 dbSNP
rs1022227174 1651 dbSNP
rs1248777112 1651 dbSNP
rs1212176395 1653 dbSNP
rs571126746 1655 dbSNP
rs755707666 1657 dbSNP
rs121434423 1661 dbSNP
rs1064793137 1663 dbSNP
rs1175580019 1663 dbSNP
rs750210287 1665 dbSNP
rs1427480444 1666 dbSNP
rs1294245027 1669 dbSNP
rs1219700063 1670 dbSNP
rs1369606098 1671 dbSNP
rs1173969061 1672 dbSNP
rs1323868891 1674 dbSNP
rs1417119878 1676 dbSNP
rs1439882613 1676 dbSNP
rs1400848793 1677 dbSNP
rs1349040611 1681 dbSNP
rs964557452 1683 dbSNP
rs1018075454 1684 dbSNP
rs1463734892 1690 dbSNP
rs1355088234 1691 dbSNP
rs1371359675 1693 dbSNP
rs767303516 1695 dbSNP
rs1433882102 1698 dbSNP
rs1427840404 1700 dbSNP
rs1192368270 1701 dbSNP
rs1468313178 1705 dbSNP
rs1239173649 1709 dbSNP
rs1200072578 1710 dbSNP
rs1479465684 1711 dbSNP
rs1346134061 1713 dbSNP
rs1250455537 1714 dbSNP
rs756972470 1721 dbSNP
rs867919965 1729 dbSNP
rs1301159117 1732 dbSNP
rs1190004222 1734 dbSNP
rs1233479729 1735 dbSNP
rs1377289578 1736 dbSNP
rs1008969968 1737 dbSNP
rs1393322295 1738 dbSNP
rs1394561582 1739 dbSNP
rs1250812564 1741 dbSNP
rs1297868383 1743 dbSNP
rs1182258521 1746 dbSNP
rs1469009371 1749 dbSNP
rs1466604623 1750 dbSNP
rs890558836 1752 dbSNP
rs1377423780 1753 dbSNP
rs1026312296 1761 dbSNP
rs1420087312 1765 dbSNP
rs1172241719 1770 dbSNP
rs1409301380 1771 dbSNP
rs606231383 1771 dbSNP
rs1208767118 1772 dbSNP
rs1381252595 1772 dbSNP
rs551588378 1773 dbSNP
rs1417757274 1774 dbSNP
rs1249368692 1779 dbSNP
rs764119124 1781 dbSNP
rs1368363383 1782 dbSNP
rs1334953984 1783 dbSNP
rs864622513 1786 dbSNP
rs1339234939 1787 dbSNP
rs1277592414 1788 dbSNP
rs899391416 1789 dbSNP
rs1210012759 1792 dbSNP
rs1354366394 1793 dbSNP
rs1288122892 1794 dbSNP
rs1213194580 1795 dbSNP
rs759759832 1796 dbSNP
rs1335008737 1797 dbSNP
rs1306555468 1799 dbSNP
rs1396826999 1801 dbSNP
rs1037920678 1808 dbSNP
rs1242477025 1809 dbSNP
rs948868401 1812 dbSNP
rs1064793138 1813 dbSNP
rs753906369 1820 dbSNP
rs1361710548 1826 dbSNP
rs1160863716 1831 dbSNP
rs1452075582 1832 dbSNP
rs1461466304 1836 dbSNP
rs894657723 1837 dbSNP
rs1391745705 1840 dbSNP
rs1187747006 1844 dbSNP
rs766727386 1845 dbSNP
rs760908706 1846 dbSNP
rs773271648 1848 dbSNP
rs1057491518 1855 dbSNP
rs1429110767 1858 dbSNP
rs1286243033 1859 dbSNP
rs376692379 1860 dbSNP
rs1356681148 1861 dbSNP
rs1455642086 1863 dbSNP
rs1349595855 1865 dbSNP
rs772532758 1866 dbSNP
rs1245731033 1868 dbSNP
rs1337263079 1871 dbSNP
rs1291719585 1872 dbSNP
rs1353039336 1873 dbSNP
rs762069368 1875 dbSNP
rs865998453 1876 dbSNP
rs1341281240 1878 dbSNP
rs1320776392 1879 dbSNP
rs537524649 1880 dbSNP
rs1446194780 1883 dbSNP
rs769083453 1885 dbSNP
rs1164234556 1887 dbSNP
rs1463384199 1888 dbSNP
rs748808313 1890 dbSNP
rs779492558 1891 dbSNP
rs1477857724 1893 dbSNP
rs1243346241 1894 dbSNP
rs1158982977 1895 dbSNP
rs945025237 1896 dbSNP
rs1446379797 1898 dbSNP
rs1267736842 1899 dbSNP
rs1215300649 1900 dbSNP
rs1467016544 1902 dbSNP
rs769364770 1903 dbSNP
rs1376520680 1905 dbSNP
rs1232905914 1911 dbSNP
rs768027510 1912 dbSNP
rs1292056473 1913 dbSNP
rs1318628871 1916 dbSNP
rs1272027944 1917 dbSNP
rs1225830078 1919 dbSNP
rs780686644 1920 dbSNP
rs1048053843 1921 dbSNP
rs1254407319 1922 dbSNP
rs1337583682 1925 dbSNP
rs1239924050 1926 dbSNP
rs1056201063 1927 dbSNP
rs1392820474 1928 dbSNP
rs762593109 1931 dbSNP
rs1348853211 1933 dbSNP
rs1237609484 1935 dbSNP
rs1324719289 1936 dbSNP
rs772895457 1937 dbSNP
rs757137495 1938 dbSNP
rs751311265 1939 dbSNP
rs868686446 1941 dbSNP
rs1165681939 1945 dbSNP
rs754571030 1948 dbSNP
rs777860096 1951 dbSNP
rs374016704 1952 dbSNP
rs753643819 1954 dbSNP
rs1466920594 1960 dbSNP
rs369804280 1963 dbSNP
rs1213252544 1965 dbSNP
rs1438643656 1968 dbSNP
rs766602616 1970 dbSNP
rs964651735 1971 dbSNP
rs1000062904 1972 dbSNP
rs1338885062 1974 dbSNP
rs1304798916 1975 dbSNP
rs766263986 1980 dbSNP
rs568982763 1981 dbSNP
rs1369157077 1982 dbSNP
rs760645169 1983 dbSNP
rs1233847850 1984 dbSNP
rs1447011194 1984 dbSNP
rs577523638 1985 dbSNP
rs1399290945 1987 dbSNP
rs767628860 1988 dbSNP
rs1002639796 1989 dbSNP
rs762241650 1989 dbSNP
rs1402302169 1990 dbSNP
rs774639210 1992 dbSNP
rs769175471 1994 dbSNP
rs1394213513 1999 dbSNP
rs1178993872 2001 dbSNP
rs910183434 2003 dbSNP
rs374836827 2004 dbSNP
rs1234805727 2007 dbSNP
rs1180010076 2008 dbSNP
rs756070538 2012 dbSNP
rs775945666 2013 dbSNP
rs1213580423 2017 dbSNP
rs1346381343 2020 dbSNP
rs1280287025 2022 dbSNP
rs1224662668 2024 dbSNP
rs1376070697 2028 dbSNP
rs1277342722 2029 dbSNP
rs774738278 2030 dbSNP
rs1233353943 2031 dbSNP
rs116068332 2033 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions TZM-bl
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM1462574. RNA binding protein: AGO2. Condition:TZM-bl ami BaL ...

- Whisnant AW; Bogerd HP; Flores O; Ho P; et al., 2013, mBio.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' ggGUGGUCGACGAG--GGACcgggu 5'
            ||||  || |||  ||||     
Target 5' --CACCUCCUCCUCCUCCUG----- 3'
 		1 - 18
Article - Whisnant AW; Bogerd HP; Flores O; Ho P; et al.
- mBio, 2013
UNLABELLED: The question of how HIV-1 interfaces with cellular microRNA (miRNA) biogenesis and effector mechanisms has been highly controversial. Here, we first used deep sequencing of small RNAs present in two different infected cell lines (TZM-bl and C8166) and two types of primary human cells (CD4(+) peripheral blood mononuclear cells [PBMCs] and macrophages) to unequivocally demonstrate that HIV-1 does not encode any viral miRNAs. Perhaps surprisingly, we also observed that infection of T cells by HIV-1 has only a modest effect on the expression of cellular miRNAs at early times after infection. Comprehensive analysis of miRNA binding to the HIV-1 genome using the photoactivatable ribonucleoside-induced cross-linking and immunoprecipitation (PAR-CLIP) technique revealed several binding sites for cellular miRNAs, a subset of which were shown to be capable of mediating miRNA-mediated repression of gene expression. However, the main finding from this analysis is that HIV-1 transcripts are largely refractory to miRNA binding, most probably due to extensive viral RNA secondary structure. Together, these data demonstrate that HIV-1 neither encodes viral miRNAs nor strongly influences cellular miRNA expression, at least early after infection, and imply that HIV-1 transcripts have evolved to avoid inhibition by preexisting cellular miRNAs by adopting extensive RNA secondary structures that occlude most potential miRNA binding sites. IMPORTANCE: MicroRNAs (miRNAs) are a ubiquitous class of small regulatory RNAs that serve as posttranscriptional regulators of gene expression. Previous work has suggested that HIV-1 might subvert the function of the cellular miRNA machinery by expressing viral miRNAs or by dramatically altering the level of cellular miRNA expression. Using very sensitive approaches, we now demonstrate that neither of these ideas is in fact correct. Moreover, HIV-1 transcripts appear to largely avoid regulation by cellular miRNAs by adopting an extensive RNA secondary structure that occludes the ability of cellular miRNAs to interact with viral mRNAs. Together, these data suggest that HIV-1, rather than seeking to control miRNA function in infected cells, has instead evolved a mechanism to become largely invisible to cellular miRNA effector mechanisms.
LinkOut: [PMID: 23592263]
CLIP-seq Support 1 for dataset GSM1462574
Method / RBP PAR-CLIP / AGO2
Cell line / Condition TZM-bl / TZM-bl ami BaL
Location of target site ENST00000427170.2 | 3UTR | caccuccuccuccuccug
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23592263 / GSE59944
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
87 hsa-miR-4640-5p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT100106 ABT1 activator of basal transcription 1 2 8
MIRT248144 LMBR1L limb development membrane protein 1 like 2 2
MIRT327062 KLHL15 kelch like family member 15 2 2
MIRT347231 GATAD2A GATA zinc finger domain containing 2A 2 2
MIRT450221 CENPN centromere protein N 2 2
MIRT451264 NDUFA11 NADH:ubiquinone oxidoreductase subunit A11 2 2
MIRT452701 C1orf226 chromosome 1 open reading frame 226 2 2
MIRT453212 CERS1 ceramide synthase 1 2 2
MIRT454822 POLR2J3 RNA polymerase II subunit J3 2 2
MIRT454883 RAD50 RAD50 double strand break repair protein 2 2
MIRT455783 TAF8 TATA-box binding protein associated factor 8 2 2
MIRT455858 TMEM254 transmembrane protein 254 2 2
MIRT457615 UPK3BL uroplakin 3B like 1 2 2
MIRT457822 ITPRIP inositol 1,4,5-trisphosphate receptor interacting protein 2 4
MIRT458344 NOC2L NOC2 like nucleolar associated transcriptional repressor 2 2
MIRT458376 ITM2C integral membrane protein 2C 2 2
MIRT458928 SAMD4B sterile alpha motif domain containing 4B 2 2
MIRT459066 WFIKKN2 WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2 2 2
MIRT460138 ASB16 ankyrin repeat and SOCS box containing 16 2 2
MIRT460818 FSTL4 follistatin like 4 2 2
MIRT461285 COX10 COX10, heme A:farnesyltransferase cytochrome c oxidase assembly factor 2 2
MIRT462738 EFNB1 ephrin B1 2 2
MIRT464556 UBTF upstream binding transcription factor, RNA polymerase I 2 2
MIRT477910 DUSP2 dual specificity phosphatase 2 2 2
MIRT479073 CNNM4 cyclin and CBS domain divalent metal cation transport mediator 4 2 4
MIRT479534 CDC5L cell division cycle 5 like 2 4
MIRT485628 EEPD1 endonuclease/exonuclease/phosphatase family domain containing 1 2 2
MIRT489896 PPIC peptidylprolyl isomerase C 2 4
MIRT490737 SRCIN1 SRC kinase signaling inhibitor 1 2 2
MIRT491201 MLLT1 MLLT1, super elongation complex subunit 2 4
MIRT492681 PHYHIP phytanoyl-CoA 2-hydroxylase interacting protein 2 2
MIRT494593 ATG7 autophagy related 7 2 2
MIRT495061 PADI3 peptidyl arginine deiminase 3 2 4
MIRT496623 TMEM67 transmembrane protein 67 2 2
MIRT497177 ZBTB40 zinc finger and BTB domain containing 40 2 2
MIRT498217 TLN2 talin 2 2 2
MIRT498306 BCL11B B-cell CLL/lymphoma 11B 2 2
MIRT499668 NPHP3 nephrocystin 3 2 2
MIRT508080 ANKRD52 ankyrin repeat domain 52 2 2
MIRT509707 ANKRD23 ankyrin repeat domain 23 2 2
MIRT509841 FOS Fos proto-oncogene, AP-1 transcription factor subunit 2 2
MIRT512814 ARRDC2 arrestin domain containing 2 2 2
MIRT513353 SLIT1 slit guidance ligand 1 2 2
MIRT514293 FXYD5 FXYD domain containing ion transport regulator 5 2 2
MIRT516598 FAM89A family with sequence similarity 89 member A 2 4
MIRT516616 DARS2 aspartyl-tRNA synthetase 2, mitochondrial 2 2
MIRT518348 CCL5 C-C motif chemokine ligand 5 2 2
MIRT520130 WSB1 WD repeat and SOCS box containing 1 2 2
MIRT522072 ORAI2 ORAI calcium release-activated calcium modulator 2 2 2
MIRT526461 OSBPL5 oxysterol binding protein like 5 2 2
MIRT528278 MBL2 mannose binding lectin 2 2 2
MIRT534844 RAB15 RAB15, member RAS oncogene family 2 4
MIRT542245 HSPA4L heat shock protein family A (Hsp70) member 4 like 2 2
MIRT543299 ZNF585B zinc finger protein 585B 2 2
MIRT552456 ZNF410 zinc finger protein 410 2 2
MIRT553641 TJAP1 tight junction associated protein 1 2 2
MIRT557103 HOXA3 homeobox A3 2 2
MIRT570782 FANCA Fanconi anemia complementation group A 2 2
MIRT630912 ZMAT2 zinc finger matrin-type 2 2 2
MIRT631034 ZNF878 zinc finger protein 878 2 2
MIRT639017 AAK1 AP2 associated kinase 1 2 2
MIRT648596 ZYG11B zyg-11 family member B, cell cycle regulator 2 2
MIRT648939 ATP5A1 ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle 2 2
MIRT652834 TACO1 translational activator of cytochrome c oxidase I 2 2
MIRT659347 CSRP1 cysteine and glycine rich protein 1 2 2
MIRT664163 APOBEC3F apolipoprotein B mRNA editing enzyme catalytic subunit 3F 2 2
MIRT670511 ZSCAN22 zinc finger and SCAN domain containing 22 2 2
MIRT671246 TMEM41B transmembrane protein 41B 2 2
MIRT672120 ATP6V0A2 ATPase H+ transporting V0 subunit a2 2 2
MIRT672313 CD3D CD3d molecule 2 2
MIRT672543 BRMS1L breast cancer metastasis-suppressor 1 like 2 2
MIRT673036 SGPL1 sphingosine-1-phosphate lyase 1 2 2
MIRT673814 DARS aspartyl-tRNA synthetase 2 2
MIRT674858 GINM1 glycoprotein integral membrane 1 2 2
MIRT674970 SH3BP2 SH3 domain binding protein 2 2 2
MIRT675185 KIF1C kinesin family member 1C 2 2
MIRT675219 UGDH UDP-glucose 6-dehydrogenase 2 2
MIRT675558 MED16 mediator complex subunit 16 2 2
MIRT682566 EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1 2 2
MIRT684640 PDE4C phosphodiesterase 4C 2 2
MIRT689722 ATXN2 ataxin 2 2 2
MIRT693594 SLC39A1 solute carrier family 39 member 1 2 2
MIRT704745 CDKN2B cyclin dependent kinase inhibitor 2B 2 2
MIRT712779 ZNF154 zinc finger protein 154 2 2
MIRT718118 OTOF otoferlin 2 2
MIRT720115 SAMD4A sterile alpha motif domain containing 4A 2 2
MIRT720275 EIF1AD eukaryotic translation initiation factor 1A domain containing 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-4640 Gemcitabine 60750 NSC613327 approved resistant High Pancreatic Cancer cell line (PANC-1)
hsa-mir-4640 Fluorouracil 3385 NSC19893 approved resistant High Pancreatic Cancer cell line (PANC-1)
hsa-mir-4640 Cisplatin 5460033 NSC119875 approved resistant cell line (BxPC3)
hsa-miR-4640-5p Platinum 23939 sensitive High Ovarian Cancer tissue
hsa-miR-4640-5p Paclitaxel 36314 NSC125973 approved resistant High Non-Small Cell Lung Cancer cell line (A549)
hsa-miR-4640-5p Gemcitabine 60750 NSC613327 approved resistant High Pancreatic Cancer cell line (AsPC-1)
hsa-miR-4640-5p Gefitinib 123631 NSC715055 approved resistant cell line (PC9)
hsa-miR-4640-5p Osimertinib 71496458 NSC779217 approved resistant cell line (HCC827)
hsa-miR-4640-5p Osimertinib 71496458 NSC779217 approved resistant cell line (PC9)
hsa-miR-4640-5p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-4640-5p Gefitinib 123631 NSC715055 approved resistant cell line (HCC827)
hsa-miR-4640-5p Osimertinib 71496458 NSC779217 approved sensitive cell line (H1975)
hsa-miR-4640-5p Paclitaxel 36314 NSC125973 approved resistant cell line (A2780)
hsa-miR-4640-5p Docetaxel+Cisplatin+5-Fluorouracil resistant tissue (hypopharyngeal squamous cell carcinoma)

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