miRTarBase - #MIRT453382


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pre-miRNA Information
pre-miRNA hsa-mir-4433a   
Genomic Coordinates chr2: 64340759 - 64340839
Description Homo sapiens miR-4433a stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-4433a-3p
Sequence 51| ACAGGAGUGGGGGUGGGACAU |71
Evidence Experimental
Experiments Illumina
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs751480515 9 dbSNP
rs557760377 15 dbSNP
rs1479580865 20 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol RHD   
Synonyms CD240D, DIIIc, RH, RH30, RHCED, RHDVA(TT), RHDel, RHPII, RHXIII, Rh4, RhDCw, RhII, RhK562-II, RhPI
Description Rh blood group D antigen
Transcript NM_001127691   
Other Transcripts NM_016124   
Expression
Putative miRNA Targets on RHD
3'UTR of RHD
(miRNA target sites are highlighted)		 
>RHD|NM_001127691|3'UTR
   1 GCAAAAGCATCCAAGAAAAACAAGGCCTGTTCAAAAACAAGACAACTTCCTCTCACTGTTGCCTGCATTTGTACGTGAGA
  81 AACGCTCATGACAGCAAAGTCTCCAATGTTCGCGCAGGCACTGGAGTCAGAGAAAATGGAGTTGAATCCTTTCTCTGCCA
 161 CTCTTTGAGGAGAATCTCACCATTTATTATGCACTGTAGAATACAACAATAAAATACAGCCATGTACCACATAACAACAT
 241 CTTGGTAAACAACAGACTGCATATATGATGGTGGTCATCCAGTAAGCTAAGGTTAATTTATTATTATTCCTTGTTTTTTT
 321 TTTTTTTTTTTTTTTTTTGAGATGTAGTCTTACTCTGTCACCCAGGCTAGAGTGCAATGGCACCATCTTGGCTCACTGCA
 401 ACCTCTACCTCCTGGGTTCAAGCAAATCTCCTGCCTCAGCCTCCAAAGTAGCTGGGATTACAGGCACCCACCACATCTGG
 481 CTAATTTTTTGTATTTTTAGTAAAGATGGGGTTTCACCATGTTGGCCAGGCTGATCTCAAACTCCTGACCTCAAGTGATC
 561 TGCCCGCCTCGGCCTCCCAAAGTGCTGGAACCACAGGCCTGAGCCACTGTGCCCAGCCTTGTTTGCTTTTTTAACAGATA
 641 ACAGTGTGCTCATAGAAACTGCTTTGACATGACTGCAATCATGTGCTTCATAGAAACTTAATTAGATTATACCACTAGAG
 721 TCTTCAGATTTTTATACTTTTTTTTTTTGAAACGGAGTCTCACTCTGTCACCAGGCTGGAGTGCAGTGCCGCAATCTCGG
 801 CTCACTGCAACCTCCGCCTCCCAGGTTCAAGCAATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGAATTACAAGTGCGCAC
 881 TACCACACCCAGCTAATTTTTGCATTTTTACTTGACAGGGTTTCACCATGTTGGCTAGGATAGTTTCACCAGGATCTCTT
 961 GGCCTCATGATCAGCCTGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGTGTGAGCCACCGTGCCCAGCCTATACTTCCC
1041 TTTTTGAATACCATTTGGTGTTTTGAAGAATTAACAGCTTTGTGAACGTGGCAGTGCTTGTGATTCAGGCTTCCATTGAG
1121 ACCAAGGGGAGAACCTGGTTGCAGGACAAACAGACGGACAGCGTGTGGCAGTGTTTAAATGCTCTTCTGAAGGCTGATAC
1201 GACAGCTCTCTGTGCACTGATTGCATATGCATCCCAAGATTATATTATTGTTTTCTACTGCTATGTGTCACACTTTGCCA
1281 AACAGGATGTGGAAAATGAATAAGCGGTTTTCTTAGGCACTTCTTAACAGACAATTGGTCAAAATGAACTCCATTGCTTA
1361 AGAAACACATAAACACCATTTAGTCACTGAACATAGCTATATGTATGGTTGTTACTATGGGAAATCTTGTTTTGCCAATT
1441 TTCTTTGAAAATTCTGGCAGACCAAGGTTCTTTTTGTTTACATAATACTTGAAAAATAAAAATGAACAAGCTAACAAACT
1521 A
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' uaCAGGGUGGGG-GUGAGGACa 5'
            | |: |:|:|  ||||||| 
Target 5' caGGCTGATCTCAAACTCCTGa 3'
 527 - 548 151.00 -17.60
2 
miRNA  3' uacAGGGUGGGGGU-GAGGACa 5'
             | | |||:|:| |||||| 
Target 5' cacTGCAACCTCTACCTCCTGg 3'
 394 - 415 134.00 -18.30
3 
miRNA  3' uacAGGGUGGGGGUGAGGAca 5'
             |::| |: ||||||:|  
Target 5' tccTTTCTCTGCCACTCTTtg 3'
 147 - 167 126.00 -15.70
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN32067204 2 COSMIC
COSN26509616 16 COSMIC
COSN1079843 18 COSMIC
COSN31570853 76 COSMIC
COSN26992205 112 COSMIC
COSN510419 118 COSMIC
COSN5026444 131 COSMIC
COSN31499120 132 COSMIC
COSN5026445 133 COSMIC
COSN30161022 156 COSMIC
COSN23014296 164 COSMIC
COSN30121014 177 COSMIC
COSN20648531 462 COSMIC
COSN32120506 469 COSMIC
COSN7989618 1022 COSMIC
COSN28581179 1060 COSMIC
COSN20290919 1117 COSMIC
COSN25825404 1154 COSMIC
COSN20209759 1259 COSMIC
COSN16507675 1476 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1368130544 8 dbSNP
rs770094850 9 dbSNP
rs774266508 13 dbSNP
rs759458425 14 dbSNP
rs1330027226 16 dbSNP
rs546926765 26 dbSNP
rs1271350060 27 dbSNP
rs201900068 37 dbSNP
rs760672661 39 dbSNP
rs1247110658 43 dbSNP
rs1335468073 46 dbSNP
rs1212980059 47 dbSNP
rs763474305 48 dbSNP
rs371912784 53 dbSNP
rs1406795418 54 dbSNP
rs756841536 58 dbSNP
rs764932087 75 dbSNP
rs750782245 76 dbSNP
rs780411525 83 dbSNP
rs747427094 84 dbSNP
rs755538977 88 dbSNP
rs781099507 92 dbSNP
rs112146441 94 dbSNP
rs758095649 96 dbSNP
rs769894940 101 dbSNP
rs1466692933 102 dbSNP
rs1298232912 103 dbSNP
rs773631197 105 dbSNP
rs749521782 106 dbSNP
rs771932822 107 dbSNP
rs1290538735 112 dbSNP
rs373760377 113 dbSNP
rs760501886 114 dbSNP
rs764144581 115 dbSNP
rs1483206803 116 dbSNP
rs775995875 122 dbSNP
rs28521963 124 dbSNP
rs1472189856 129 dbSNP
rs764731694 131 dbSNP
rs1416601051 133 dbSNP
rs994006872 136 dbSNP
rs1228306223 142 dbSNP
rs1328677127 143 dbSNP
rs1250801105 146 dbSNP
rs750020551 147 dbSNP
rs758070716 149 dbSNP
rs1311327024 154 dbSNP
rs536653464 156 dbSNP
rs1245628696 159 dbSNP
rs1485509739 160 dbSNP
rs751993650 162 dbSNP
rs755416541 164 dbSNP
rs1212714167 174 dbSNP
rs1273697429 175 dbSNP
rs1390716694 179 dbSNP
rs1342645314 180 dbSNP
rs1170619388 182 dbSNP
rs1206964858 183 dbSNP
rs1460166098 186 dbSNP
rs1254974428 188 dbSNP
rs1441413098 190 dbSNP
rs1187723214 191 dbSNP
rs1238690699 197 dbSNP
rs1474743978 206 dbSNP
rs1352276170 207 dbSNP
rs556599535 209 dbSNP
rs375414254 214 dbSNP
rs748167154 216 dbSNP
rs1432041494 221 dbSNP
rs573443769 222 dbSNP
rs1375077619 223 dbSNP
rs1292458090 224 dbSNP
rs542784970 227 dbSNP
rs1336296674 229 dbSNP
rs1310823692 231 dbSNP
rs778010642 233 dbSNP
rs1324730846 238 dbSNP
rs1430056904 240 dbSNP
rs1296808709 242 dbSNP
rs1342708915 245 dbSNP
rs1230340053 247 dbSNP
rs1277922600 249 dbSNP
rs1343929498 251 dbSNP
rs1200659352 253 dbSNP
rs1215083396 255 dbSNP
rs1280183325 260 dbSNP
rs1307924077 281 dbSNP
rs1347462322 283 dbSNP
rs1235700376 286 dbSNP
rs1281251467 293 dbSNP
rs1232416175 294 dbSNP
rs1282534808 297 dbSNP
rs1486071593 298 dbSNP
rs1486514239 301 dbSNP
rs1175150982 311 dbSNP
rs1186389627 311 dbSNP
rs1426181305 311 dbSNP
rs1210719813 312 dbSNP
rs28378715 312 dbSNP
rs1171597988 313 dbSNP
rs952385886 313 dbSNP
rs1195000709 314 dbSNP
rs1215746801 314 dbSNP
rs1232359506 314 dbSNP
rs1259440485 314 dbSNP
rs1288623121 314 dbSNP
rs1304222028 314 dbSNP
rs1317831918 314 dbSNP
rs1359989962 314 dbSNP
rs1370623851 314 dbSNP
rs1388539141 314 dbSNP
rs1489741645 314 dbSNP
rs199503320 314 dbSNP
rs71014352 314 dbSNP
rs71577756 314 dbSNP
rs28569996 315 dbSNP
rs1479502330 316 dbSNP
rs1253076776 317 dbSNP
rs1453481903 317 dbSNP
rs1191297838 318 dbSNP
rs1178751301 320 dbSNP
rs1158314696 321 dbSNP
rs1401032646 321 dbSNP
rs1343408839 322 dbSNP
rs1459379614 323 dbSNP
rs1326735995 324 dbSNP
rs1380725756 324 dbSNP
rs1453401342 325 dbSNP
rs1438993204 326 dbSNP
rs1171429748 327 dbSNP
rs1311690173 327 dbSNP
rs1396357877 328 dbSNP
rs1305269856 329 dbSNP
rs1214848092 330 dbSNP
rs1324095179 330 dbSNP
rs1414552020 331 dbSNP
rs1467584581 337 dbSNP
rs1211469811 338 dbSNP
rs1234202752 339 dbSNP
rs369069403 340 dbSNP
rs1198811870 341 dbSNP
rs1444760067 343 dbSNP
rs1332421928 345 dbSNP
rs559317219 346 dbSNP
rs1432373807 347 dbSNP
rs1176443877 359 dbSNP
rs1405509589 364 dbSNP
rs1438964062 370 dbSNP
rs894419154 371 dbSNP
rs1165482232 397 dbSNP
rs1393880358 404 dbSNP
rs1459897024 406 dbSNP
rs181063822 408 dbSNP
rs1214076171 411 dbSNP
rs1355379842 425 dbSNP
rs1441748418 429 dbSNP
rs1272143742 446 dbSNP
rs1234442934 450 dbSNP
rs1305662570 457 dbSNP
rs1333547688 466 dbSNP
rs1206600064 468 dbSNP
rs1238549313 469 dbSNP
rs1467921378 470 dbSNP
rs544946241 472 dbSNP
rs1254511536 475 dbSNP
rs1230970431 485 dbSNP
rs1486508989 485 dbSNP
rs1478043568 491 dbSNP
rs1166845006 504 dbSNP
rs1416815583 509 dbSNP
rs1474168582 511 dbSNP
rs1412107145 512 dbSNP
rs1172085798 526 dbSNP
rs546241222 549 dbSNP
rs147810784 566 dbSNP
rs1415725314 567 dbSNP
rs1312625635 569 dbSNP
rs530884028 571 dbSNP
rs1433495696 572 dbSNP
rs1271446381 585 dbSNP
rs1339399873 587 dbSNP
rs1213664139 588 dbSNP
rs762706272 589 dbSNP
rs763973515 593 dbSNP
rs1270391773 595 dbSNP
rs1349573362 603 dbSNP
rs1211382987 607 dbSNP
rs1331923553 615 dbSNP
rs1256537462 616 dbSNP
rs1484684684 618 dbSNP
rs1430057014 627 dbSNP
rs35558497 627 dbSNP
rs1268470359 633 dbSNP
rs1364245040 637 dbSNP
rs113683142 639 dbSNP
rs1166393348 639 dbSNP
rs1215741337 644 dbSNP
rs1216253381 649 dbSNP
rs1373968034 656 dbSNP
rs1258639782 660 dbSNP
rs1326531949 669 dbSNP
rs761055335 681 dbSNP
rs1333811046 683 dbSNP
rs1294728755 685 dbSNP
rs185598292 690 dbSNP
rs1234555397 692 dbSNP
rs530166476 694 dbSNP
rs1274625013 695 dbSNP
rs1345386079 701 dbSNP
rs1206857301 704 dbSNP
rs751320058 711 dbSNP
rs1446329189 715 dbSNP
rs547158325 718 dbSNP
rs1254957726 724 dbSNP
rs188845162 726 dbSNP
rs1476145101 728 dbSNP
rs1471335995 734 dbSNP
rs1159490131 735 dbSNP
rs1384925160 736 dbSNP
rs112102374 738 dbSNP
rs1395964238 738 dbSNP
rs1399462026 738 dbSNP
rs1194940595 750 dbSNP
rs1417788288 753 dbSNP
rs1460155951 754 dbSNP
rs756911715 755 dbSNP
rs1279885546 757 dbSNP
rs1391964490 758 dbSNP
rs1206726009 761 dbSNP
rs1349946695 761 dbSNP
rs1400326814 763 dbSNP
rs539246400 768 dbSNP
rs1213332685 792 dbSNP
rs1251428079 795 dbSNP
rs1421073912 799 dbSNP
rs1316585326 800 dbSNP
rs552406906 805 dbSNP
rs143570282 807 dbSNP
rs1363572104 813 dbSNP
rs1042896468 816 dbSNP
rs181689405 817 dbSNP
rs558251262 827 dbSNP
rs1285705338 833 dbSNP
rs1356855692 834 dbSNP
rs1388177237 841 dbSNP
rs1392765638 842 dbSNP
rs573663814 849 dbSNP
rs1334889433 855 dbSNP
rs28744664 856 dbSNP
rs1448162228 859 dbSNP
rs28654325 866 dbSNP
rs985518613 870 dbSNP
rs1474494974 874 dbSNP
rs187343119 877 dbSNP
rs191818983 878 dbSNP
rs144887090 884 dbSNP
rs1482254249 888 dbSNP
rs1190724272 896 dbSNP
rs1258885791 898 dbSNP
rs1475149000 899 dbSNP
rs184060204 902 dbSNP
rs1156988867 903 dbSNP
rs1387448128 907 dbSNP
rs375930288 914 dbSNP
rs28668998 916 dbSNP
rs1395537936 918 dbSNP
rs1407823579 922 dbSNP
rs1314458591 923 dbSNP
rs749995927 929 dbSNP
rs185841551 944 dbSNP
rs1310680979 952 dbSNP
rs1309265149 960 dbSNP
rs1228466807 961 dbSNP
rs1250921073 963 dbSNP
rs1336170443 964 dbSNP
rs1340272871 969 dbSNP
rs1213518313 977 dbSNP
rs1340779739 983 dbSNP
rs1238080977 984 dbSNP
rs1485662617 991 dbSNP
rs530125988 997 dbSNP
rs1277360173 1002 dbSNP
rs1355448942 1004 dbSNP
rs1240474731 1005 dbSNP
rs1278975378 1011 dbSNP
rs1484442575 1012 dbSNP
rs1193251299 1021 dbSNP
rs1213560571 1022 dbSNP
rs1175345259 1023 dbSNP
rs1375773725 1036 dbSNP
rs574642512 1054 dbSNP
rs368881741 1060 dbSNP
rs1364198168 1065 dbSNP
rs1382895173 1066 dbSNP
rs1437556820 1082 dbSNP
rs1363373682 1084 dbSNP
rs1191432716 1088 dbSNP
rs1180143419 1089 dbSNP
rs189984474 1090 dbSNP
rs965500310 1094 dbSNP
rs1440525497 1117 dbSNP
rs1173315199 1118 dbSNP
rs1486463676 1124 dbSNP
rs1393346578 1132 dbSNP
rs1246866007 1135 dbSNP
rs1436668902 1143 dbSNP
rs560638872 1145 dbSNP
rs1195040391 1153 dbSNP
rs182598131 1156 dbSNP
rs371911452 1157 dbSNP
rs1173666708 1158 dbSNP
rs976533887 1163 dbSNP
rs1454243420 1164 dbSNP
rs1402852559 1173 dbSNP
rs1386465201 1174 dbSNP
rs1390565939 1186 dbSNP
rs1326572158 1193 dbSNP
rs1304385995 1197 dbSNP
rs552394749 1201 dbSNP
rs1378899644 1202 dbSNP
rs1421485437 1203 dbSNP
rs1447055547 1209 dbSNP
rs1217878318 1211 dbSNP
rs1309604117 1213 dbSNP
rs1302241208 1214 dbSNP
rs569207388 1216 dbSNP
rs531914295 1222 dbSNP
rs667141 1225 dbSNP
rs924074966 1226 dbSNP
rs1215203921 1229 dbSNP
rs1345043699 1244 dbSNP
rs1487935979 1249 dbSNP
rs667179 1259 dbSNP
rs1409872289 1265 dbSNP
rs935502690 1272 dbSNP
rs770743537 1273 dbSNP
rs989700916 1275 dbSNP
rs548486072 1277 dbSNP
rs369293996 1279 dbSNP
rs915463652 1285 dbSNP
rs1326629504 1305 dbSNP
rs1257058360 1306 dbSNP
rs567122200 1307 dbSNP
rs1045469027 1328 dbSNP
rs1374427214 1332 dbSNP
rs1223749835 1333 dbSNP
rs1194634813 1335 dbSNP
rs1240404089 1371 dbSNP
rs1458548936 1372 dbSNP
rs1193173869 1378 dbSNP
rs765378898 1382 dbSNP
rs1455608404 1388 dbSNP
rs1199714783 1393 dbSNP
rs1320802076 1398 dbSNP
rs1218850323 1404 dbSNP
rs1234397896 1410 dbSNP
rs1480813144 1415 dbSNP
rs1181391710 1419 dbSNP
rs1372618978 1422 dbSNP
rs187340486 1423 dbSNP
rs906568070 1436 dbSNP
rs1413091242 1444 dbSNP
rs552749796 1446 dbSNP
rs566599020 1447 dbSNP
rs1402117900 1459 dbSNP
rs1403822293 1466 dbSNP
rs939403903 1467 dbSNP
rs752877879 1468 dbSNP
rs538831538 1482 dbSNP
rs755616258 1483 dbSNP
rs368454829 1484 dbSNP
rs115878715 1487 dbSNP
rs141992241 1489 dbSNP
rs1226287383 1498 dbSNP
rs190604714 1499 dbSNP
rs1225876530 1504 dbSNP
rs1307693791 1513 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions TZM-bl
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM1462574. RNA binding protein: AGO2. Condition:TZM-bl ami BaL ...

- Whisnant AW; Bogerd HP; Flores O; Ho P; et al., 2013, mBio.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' uacagggUGGGG-GUGAGGACa 5'
                 |:|:|  ||||||| 
Target 5' -------AUCUCAAACUCCUGa 3'
 		1 - 15
Article - Whisnant AW; Bogerd HP; Flores O; Ho P; et al.
- mBio, 2013
UNLABELLED: The question of how HIV-1 interfaces with cellular microRNA (miRNA) biogenesis and effector mechanisms has been highly controversial. Here, we first used deep sequencing of small RNAs present in two different infected cell lines (TZM-bl and C8166) and two types of primary human cells (CD4(+) peripheral blood mononuclear cells [PBMCs] and macrophages) to unequivocally demonstrate that HIV-1 does not encode any viral miRNAs. Perhaps surprisingly, we also observed that infection of T cells by HIV-1 has only a modest effect on the expression of cellular miRNAs at early times after infection. Comprehensive analysis of miRNA binding to the HIV-1 genome using the photoactivatable ribonucleoside-induced cross-linking and immunoprecipitation (PAR-CLIP) technique revealed several binding sites for cellular miRNAs, a subset of which were shown to be capable of mediating miRNA-mediated repression of gene expression. However, the main finding from this analysis is that HIV-1 transcripts are largely refractory to miRNA binding, most probably due to extensive viral RNA secondary structure. Together, these data demonstrate that HIV-1 neither encodes viral miRNAs nor strongly influences cellular miRNA expression, at least early after infection, and imply that HIV-1 transcripts have evolved to avoid inhibition by preexisting cellular miRNAs by adopting extensive RNA secondary structures that occlude most potential miRNA binding sites. IMPORTANCE: MicroRNAs (miRNAs) are a ubiquitous class of small regulatory RNAs that serve as posttranscriptional regulators of gene expression. Previous work has suggested that HIV-1 might subvert the function of the cellular miRNA machinery by expressing viral miRNAs or by dramatically altering the level of cellular miRNA expression. Using very sensitive approaches, we now demonstrate that neither of these ideas is in fact correct. Moreover, HIV-1 transcripts appear to largely avoid regulation by cellular miRNAs by adopting an extensive RNA secondary structure that occludes the ability of cellular miRNAs to interact with viral mRNAs. Together, these data suggest that HIV-1, rather than seeking to control miRNA function in infected cells, has instead evolved a mechanism to become largely invisible to cellular miRNA effector mechanisms.
LinkOut: [PMID: 23592263]
CLIP-seq Support 1 for dataset GSM1462574
Method / RBP PAR-CLIP / AGO2
Cell line / Condition TZM-bl / TZM-bl ami BaL
Location of target site ENST00000423810.2 | 3UTR | AUCUCAAACUCCUGACCUCAAG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23592263 / GSE59944
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
256 hsa-miR-4433a-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT088097 SEPT2 septin 2 2 2
MIRT143134 MGRN1 mahogunin ring finger 1 2 2
MIRT153912 NCOA3 nuclear receptor coactivator 3 2 2
MIRT154894 GNAS GNAS complex locus 2 4
MIRT200996 ZNF805 zinc finger protein 805 2 2
MIRT215729 C5ORF51 chromosome 5 open reading frame 51 2 10
MIRT235593 POFUT1 protein O-fucosyltransferase 1 2 2
MIRT263250 SGPL1 sphingosine-1-phosphate lyase 1 2 2
MIRT317951 CDC5L cell division cycle 5 like 2 4
MIRT325572 HIATL1 major facilitator superfamily domain containing 14B 2 4
MIRT354739 LSM3 LSM3 homolog, U6 small nuclear RNA and mRNA degradation associated 2 2
MIRT444552 UBE2D3 ubiquitin conjugating enzyme E2 D3 2 4
MIRT446978 SUSD5 sushi domain containing 5 2 2
MIRT451036 ZNF610 zinc finger protein 610 2 2
MIRT451596 TRPM7 transient receptor potential cation channel subfamily M member 7 2 2
MIRT452025 NLRP6 NLR family pyrin domain containing 6 2 2
MIRT452594 CA6 carbonic anhydrase 6 2 2
MIRT452768 TCEA3 transcription elongation factor A3 2 4
MIRT452959 ZNF844 zinc finger protein 844 2 2
MIRT453191 ACSF2 acyl-CoA synthetase family member 2 2 2
MIRT453382 RHD Rh blood group D antigen 2 2
MIRT453685 CEBPD CCAAT/enhancer binding protein delta 2 2
MIRT455272 DDX39B DExD-box helicase 39B 2 8
MIRT455346 BAMBI BMP and activin membrane bound inhibitor 2 2
MIRT456494 SERAC1 serine active site containing 1 2 2
MIRT456585 NID1 nidogen 1 2 2
MIRT456888 DDA1 DET1 and DDB1 associated 1 2 2
MIRT457123 APOLD1 apolipoprotein L domain containing 1 2 2
MIRT457852 ZNF324B zinc finger protein 324B 2 2
MIRT457987 APAF1 apoptotic peptidase activating factor 1 2 2
MIRT459278 APOBEC3F apolipoprotein B mRNA editing enzyme catalytic subunit 3F 2 2
MIRT459625 SLC25A33 solute carrier family 25 member 33 2 2
MIRT459715 SGK494 uncharacterized serine/threonine-protein kinase SgK494 2 2
MIRT460057 RPL22L1 ribosomal protein L22 like 1 2 2
MIRT460182 UNK unkempt family zinc finger 2 6
MIRT460288 PDE11A phosphodiesterase 11A 2 2
MIRT460841 EGF epidermal growth factor 2 4
MIRT460860 TBC1D19 TBC1 domain family member 19 2 2
MIRT461519 EMC7 ER membrane protein complex subunit 7 2 2
MIRT461729 SLC27A1 solute carrier family 27 member 1 2 4
MIRT461821 SNAP23 synaptosome associated protein 23 2 2
MIRT462066 CCDC77 coiled-coil domain containing 77 2 4
MIRT462084 MSANTD2 Myb/SANT DNA binding domain containing 2 2 2
MIRT462508 MTFMT mitochondrial methionyl-tRNA formyltransferase 2 10
MIRT464239 VCP valosin containing protein 2 2
MIRT465316 TRAF5 TNF receptor associated factor 5 2 2
MIRT466549 TBL1XR1 transducin beta like 1 X-linked receptor 1 2 2
MIRT467128 SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 2 8
MIRT468091 SHCBP1 SHC binding and spindle associated 1 2 2
MIRT469630 RAD21 RAD21 cohesin complex component 2 6
MIRT471097 PIK3C2B phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta 2 2
MIRT472704 MYBL1 MYB proto-oncogene like 1 2 2
MIRT472830 MTMR10 myotubularin related protein 10 2 2
MIRT472872 MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase 2 2
MIRT472895 MTDH metadherin 2 2
MIRT473728 MAPK1 mitogen-activated protein kinase 1 2 2
MIRT473859 MAP2K4 mitogen-activated protein kinase kinase 4 2 2
MIRT474047 LONRF1 LON peptidase N-terminal domain and ring finger 1 2 2
MIRT474297 LAMC1 laminin subunit gamma 1 2 2
MIRT474658 KLF13 Kruppel like factor 13 2 2
MIRT475234 IKZF3 IKAROS family zinc finger 3 2 2
MIRT475500 HSP90B1 heat shock protein 90 beta family member 1 2 2
MIRT475742 HERPUD1 homocysteine inducible ER protein with ubiquitin like domain 1 2 4
MIRT475793 HDGF heparin binding growth factor 2 2
MIRT477254 ERGIC2 ERGIC and golgi 2 2 2
MIRT478228 DDX52 DExD-box helicase 52 2 2
MIRT478393 DCTN5 dynactin subunit 5 2 2
MIRT478754 CS citrate synthase 2 2
MIRT478827 CRKL CRK like proto-oncogene, adaptor protein 2 4
MIRT480234 C9orf41 carnosine N-methyltransferase 1 2 2
MIRT480597 BTRC beta-transducin repeat containing E3 ubiquitin protein ligase 2 2
MIRT484121 C14orf142 GON7, KEOPS complex subunit homolog 2 2
MIRT484689 PACSIN1 protein kinase C and casein kinase substrate in neurons 1 2 2
MIRT486331 C11orf54 chromosome 11 open reading frame 54 2 4
MIRT488599 FAM3C family with sequence similarity 3 member C 2 8
MIRT488833 MRRF mitochondrial ribosome recycling factor 2 2
MIRT492523 RAB15 RAB15, member RAS oncogene family 2 4
MIRT493632 HIC2 HIC ZBTB transcriptional repressor 2 2 2
MIRT500026 ABCF2 ATP binding cassette subfamily F member 2 2 8
MIRT501075 SMAD7 SMAD family member 7 2 8
MIRT503094 BTG2 BTG anti-proliferation factor 2 2 4
MIRT503336 MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 2 2
MIRT505465 STMN1 stathmin 1 2 4
MIRT505726 SERTAD3 SERTA domain containing 3 2 4
MIRT509333 MS4A4A membrane spanning 4-domains A4A 2 2
MIRT509978 KCNMB1 potassium calcium-activated channel subfamily M regulatory beta subunit 1 2 4
MIRT513068 CHST6 carbohydrate sulfotransferase 6 2 2
MIRT513446 EMP1 epithelial membrane protein 1 2 6
MIRT513736 PSD3 pleckstrin and Sec7 domain containing 3 2 4
MIRT513996 CENPQ centromere protein Q 2 4
MIRT516538 MIXL1 Mix paired-like homeobox 2 2
MIRT517606 SAV1 salvador family WW domain containing protein 1 2 2
MIRT518064 CEP89 centrosomal protein 89 2 2
MIRT518119 RNMTL1 mitochondrial rRNA methyltransferase 3 2 2
MIRT518325 WDR92 WD repeat domain 92 2 2
MIRT519048 ABCB11 ATP binding cassette subfamily B member 11 2 2
MIRT520972 SPPL2A signal peptide peptidase like 2A 2 4
MIRT521359 RPL35A ribosomal protein L35a 2 2
MIRT523359 GTF3C6 general transcription factor IIIC subunit 6 2 2
MIRT523801 FAM63A MINDY lysine 48 deubiquitinase 1 2 2
MIRT524622 C7orf73 short transmembrane mitochondrial protein 1 2 2
MIRT525550 PHB2 prohibitin 2 2 4
MIRT529709 ZBTB49 zinc finger and BTB domain containing 49 2 2
MIRT531605 PLEKHA6 pleckstrin homology domain containing A6 2 2
MIRT532387 UMPS uridine monophosphate synthetase 2 2
MIRT534468 SCD stearoyl-CoA desaturase 2 4
MIRT537546 ETNK1 ethanolamine kinase 1 2 2
MIRT541619 C11orf31 selenoprotein H 2 2
MIRT548380 ENPP5 ectonucleotide pyrophosphatase/phosphodiesterase 5 (putative) 2 4
MIRT549523 HDDC2 HD domain containing 2 2 2
MIRT549774 SOD2 superoxide dismutase 2 2 2
MIRT550578 SLC2A5 solute carrier family 2 member 5 2 2
MIRT551498 CENPN centromere protein N 2 4
MIRT552301 ITGA3 integrin subunit alpha 3 2 2
MIRT555400 PPM1L protein phosphatase, Mg2+/Mn2+ dependent 1L 2 2
MIRT556399 LUC7L LUC7 like 2 2
MIRT557047 HOXB3 homeobox B3 2 2
MIRT558072 ERO1L endoplasmic reticulum oxidoreductase 1 alpha 1 2
MIRT559659 AHCYL2 adenosylhomocysteinase like 2 2 2
MIRT561239 ZNF354B zinc finger protein 354B 2 2
MIRT566899 LRIG2 leucine rich repeats and immunoglobulin like domains 2 2 2
MIRT568786 FAM120B family with sequence similarity 120B 2 2
MIRT574014 MRPL12 mitochondrial ribosomal protein L12 2 2
MIRT574885 Dnajc6 DnaJ heat shock protein family (Hsp40) member C6 2 2
MIRT575243 Serping1 serine (or cysteine) peptidase inhibitor, clade G, member 1 2 2
MIRT576194 Vsig2 V-set and immunoglobulin domain containing 2 2 2
MIRT576309 Acbd7 acyl-Coenzyme A binding domain containing 7 2 2
MIRT576484 Lhx4 LIM homeobox protein 4 2 3
MIRT576646 Mill2 MHC I like leukocyte 2 1 1
MIRT576708 Kras Kirsten rat sarcoma viral oncogene homolog 2 2
MIRT576855 Socs6 suppressor of cytokine signaling 6 2 2
MIRT576950 Aldoa aldolase A, fructose-bisphosphate 2 2
MIRT617133 ZNF556 zinc finger protein 556 2 4
MIRT617928 ZNF783 zinc finger family member 783 2 2
MIRT618981 MRPS16 mitochondrial ribosomal protein S16 2 2
MIRT621100 SIX3 SIX homeobox 3 2 2
MIRT624537 BROX BRO1 domain and CAAX motif containing 2 2
MIRT625663 C2orf48 chromosome 2 open reading frame 48 2 2
MIRT627059 DCTN6 dynactin subunit 6 2 2
MIRT628319 CLPB ClpB homolog, mitochondrial AAA ATPase chaperonin 2 2
MIRT630859 ENTPD5 ectonucleoside triphosphate diphosphohydrolase 5 2 2
MIRT632295 TMEM65 transmembrane protein 65 2 2
MIRT634115 ZNF207 zinc finger protein 207 2 2
MIRT634736 CYP20A1 cytochrome P450 family 20 subfamily A member 1 2 2
MIRT635655 NDST3 N-deacetylase and N-sulfotransferase 3 2 2
MIRT635772 PDCL3 phosducin like 3 2 2
MIRT635911 LILRA2 leukocyte immunoglobulin like receptor A2 2 2
MIRT636365 OGFRL1 opioid growth factor receptor like 1 2 4
MIRT637251 GLRX2 glutaredoxin 2 2 2
MIRT638705 FZD4 frizzled class receptor 4 2 2
MIRT639640 PREX2 phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 2 2 2
MIRT639676 PPEF2 protein phosphatase with EF-hand domain 2 2 4
MIRT642267 SMIM17 small integral membrane protein 17 2 2
MIRT642372 ZNF581 zinc finger protein 581 2 2
MIRT643545 SLC25A17 solute carrier family 25 member 17 2 2
MIRT647994 PDE12 phosphodiesterase 12 2 2
MIRT649094 NOM1 nucleolar protein with MIF4G domain 1 2 2
MIRT650993 ZNF770 zinc finger protein 770 2 2
MIRT651956 UBE2N ubiquitin conjugating enzyme E2 N 2 2
MIRT652977 SUN2 Sad1 and UNC84 domain containing 2 2 2
MIRT654389 RBM12B RNA binding motif protein 12B 2 2
MIRT655637 OLFML2A olfactomedin like 2A 2 2
MIRT655729 NRXN3 neurexin 3 2 2
MIRT658171 FCHSD1 FCH and double SH3 domains 1 2 2
MIRT660937 ACOX1 acyl-CoA oxidase 1 2 2
MIRT662112 CERKL ceramide kinase like 2 2
MIRT662302 MPV17L MPV17 mitochondrial inner membrane protein like 2 2
MIRT662993 TMEM59 transmembrane protein 59 2 2
MIRT663071 SFR1 SWI5 dependent homologous recombination repair protein 1 2 2
MIRT663704 ABHD17B abhydrolase domain containing 17B 2 2
MIRT663864 MUC20 mucin 20, cell surface associated 2 2
MIRT665185 HAUS5 HAUS augmin like complex subunit 5 2 4
MIRT665402 WEE1 WEE1 G2 checkpoint kinase 2 2
MIRT665688 TNPO3 transportin 3 2 2
MIRT665795 TMEM170A transmembrane protein 170A 2 2
MIRT665847 TIAL1 TIA1 cytotoxic granule associated RNA binding protein like 1 2 2
MIRT666999 PDPN podoplanin 2 2
MIRT667598 LIPC lipase C, hepatic type 2 2
MIRT668576 ELMSAN1 ELM2 and Myb/SANT domain containing 1 2 4
MIRT670960 UGGT1 UDP-glucose glycoprotein glucosyltransferase 1 2 2
MIRT671187 ZNF891 zinc finger protein 891 2 2
MIRT671739 ZNF451 zinc finger protein 451 2 2
MIRT672745 ZNF585B zinc finger protein 585B 2 4
MIRT673446 ZNF583 zinc finger protein 583 2 2
MIRT679843 GPR75 G protein-coupled receptor 75 2 2
MIRT680556 ZNF584 zinc finger protein 584 2 2
MIRT680661 C1orf210 chromosome 1 open reading frame 210 2 2
MIRT681285 RFC2 replication factor C subunit 2 2 2
MIRT683264 ZNF329 zinc finger protein 329 2 2
MIRT684519 C1orf174 chromosome 1 open reading frame 174 2 2
MIRT685065 GEMIN4 gem nuclear organelle associated protein 4 2 2
MIRT685157 DTWD2 DTW domain containing 2 2 2
MIRT685168 ERCC1 ERCC excision repair 1, endonuclease non-catalytic subunit 2 2
MIRT685470 CACNG8 calcium voltage-gated channel auxiliary subunit gamma 8 2 2
MIRT686001 NEK4 NIMA related kinase 4 2 2
MIRT687027 RNF24 ring finger protein 24 2 2
MIRT687543 MOB1B MOB kinase activator 1B 2 2
MIRT687592 MANEAL mannosidase endo-alpha like 2 2
MIRT687753 KIAA1328 KIAA1328 2 2
MIRT688050 GLUL glutamate-ammonia ligase 2 2
MIRT688374 ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1 2 2
MIRT688802 CBFA2T3 CBFA2/RUNX1 translocation partner 3 2 2
MIRT688957 ATXN3 ataxin 3 2 2
MIRT689281 C5AR2 complement component 5a receptor 2 2 2
MIRT689988 NNMT nicotinamide N-methyltransferase 2 2
MIRT689997 MMP17 matrix metallopeptidase 17 2 2
MIRT690014 LUZP2 leucine zipper protein 2 2 2
MIRT690161 ELP3 elongator acetyltransferase complex subunit 3 2 2
MIRT690379 ZSWIM7 zinc finger SWIM-type containing 7 2 2
MIRT690563 MICA MHC class I polypeptide-related sequence A 2 2
MIRT691891 EVC EvC ciliary complex subunit 1 2 2
MIRT693107 SCNM1 sodium channel modifier 1 2 2
MIRT693832 ZFP64 ZFP64 zinc finger protein 2 2
MIRT694105 ZNF446 zinc finger protein 446 2 2
MIRT694179 ZNF486 zinc finger protein 486 2 2
MIRT694475 LRTOMT leucine rich transmembrane and O-methyltransferase domain containing 2 2
MIRT694998 GGA2 golgi associated, gamma adaptin ear containing, ARF binding protein 2 2 2
MIRT695031 ALG10B ALG10B, alpha-1,2-glucosyltransferase 2 2
MIRT695163 TCTN2 tectonic family member 2 2 2
MIRT695525 SLC25A34 solute carrier family 25 member 34 2 2
MIRT696067 ZNF264 zinc finger protein 264 2 2
MIRT696616 CRIPT CXXC repeat containing interactor of PDZ3 domain 2 2
MIRT696661 AGXT2 alanine--glyoxylate aminotransferase 2 2 2
MIRT696705 PNPO pyridoxamine 5'-phosphate oxidase 2 2
MIRT697173 INMT indolethylamine N-methyltransferase 2 2
MIRT697303 ZNF652 zinc finger protein 652 2 2
MIRT697491 ZBTB8B zinc finger and BTB domain containing 8B 2 2
MIRT698657 TERF2 telomeric repeat binding factor 2 2 2
MIRT699042 SOAT1 sterol O-acyltransferase 1 2 2
MIRT699185 SLX4IP SLX4 interacting protein 2 2
MIRT699598 SHOC2 SHOC2, leucine rich repeat scaffold protein 2 2
MIRT700150 RNF115 ring finger protein 115 2 2
MIRT700720 PNO1 partner of NOB1 homolog 2 2
MIRT700870 PER2 period circadian clock 2 2 2
MIRT700912 PDXK pyridoxal kinase 2 2
MIRT701095 PAPOLG poly(A) polymerase gamma 2 2
MIRT701194 OTUD3 OTU deubiquitinase 3 2 2
MIRT702203 LPP LIM domain containing preferred translocation partner in lipoma 2 2
MIRT702272 LHX4 LIM homeobox 4 2 3
MIRT703125 GPRC5A G protein-coupled receptor class C group 5 member A 2 2
MIRT703252 GNS glucosamine (N-acetyl)-6-sulfatase 2 2
MIRT703262 GNL3L G protein nucleolar 3 like 2 2
MIRT703440 FYTTD1 forty-two-three domain containing 1 2 2
MIRT704321 DCUN1D5 defective in cullin neddylation 1 domain containing 5 2 2
MIRT704393 CTSS cathepsin S 2 2
MIRT704483 CPT1A carnitine palmitoyltransferase 1A 2 2
MIRT704880 CCSER2 coiled-coil serine rich protein 2 2 2
MIRT704926 CCDC36 coiled-coil domain containing 36 2 2
MIRT705175 BZW1 basic leucine zipper and W2 domains 1 2 2
MIRT706561 EIF2AK2 eukaryotic translation initiation factor 2 alpha kinase 2 2 2
MIRT707048 TRPV2 transient receptor potential cation channel subfamily V member 2 2 2
MIRT711497 PGD phosphogluconate dehydrogenase 2 2
MIRT716644 EPGN epithelial mitogen 2 2
MIRT720083 TNRC6B trinucleotide repeat containing 6B 2 2
MIRT722288 PMPCA peptidase, mitochondrial processing alpha subunit 2 2
MIRT725468 GRAP2 GRB2-related adaptor protein 2 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-4433a Dabrafenib 44462760 NSC764134 approved resistant cell line (A375)
hsa-mir-4433a Paclitaxel 36314 NSC125973 approved resistant cell line (W1)
hsa-mir-4433a Vincristine 5978 approved resistant cell line (W1)
hsa-mir-4433a Cisplatin 5460033 NSC119875 approved resistant cell line (BxPC3)
hsa-miR-4433a-3p Platinum 23939 sensitive High Ovarian Cancer tissue
hsa-miR-4433a-3p Imatinib 5291 NSC743414 approved sensitive High Gastrointestinal Stromal Tumor cell line (882R-NC, 882R-OE, 882R-KD)
hsa-miR-4433a-3p Cisplatin 5460033 NSC119875 approved resistant High Pancreatic Cancer cell line (BxPC-3)
hsa-miR-4433a-3p Paclitaxel 36314 NSC125973 approved resistant High Non-Small Cell Lung Cancer cell line (A549)
hsa-miR-4433a-3p Imatinib 5291 NSC743414 approved sensitive High Chronic Myelogenous Leukemia tissue
hsa-miR-4433a-3p Cisplatin 5460033 NSC119875 approved resistant High Ovarian Cancer cell line (A2780CIS)
hsa-miR-4433a-3p Cisplatin 5460033 NSC119875 approved sensitive cell line (CAL-27) (mitochondrial RNA)
hsa-miR-4433a-3p Paclitaxel 36314 NSC125973 approved resistant cell line (BAS)
hsa-miR-4433a-3p Cisplatin 5460033 NSC119875 approved resistant cell line (CP20)
hsa-miR-4433a-3p Cisplatin 5460033 NSC119875 approved resistant cell line (CIS)
hsa-miR-4433a-3p Neoadjuvant chemotherapy sensitive tissue (breast cancer)
hsa-miR-4433a-3p Gemcitabine 60750 NSC613327 approved sensitive cell line (PANC-1) (1500 ng/ml)
hsa-miR-4433a-3p Gemcitabine 60750 NSC613327 approved sensitive cell line (PANC-1) (100 ng/ml)

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