miRTarBase - #MIRT453894


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pre-miRNA Information
pre-miRNA hsa-mir-3675   
Genomic Coordinates chr1: 16858949 - 16859021
Description Homo sapiens miR-3675 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-3675-5p
Sequence 12| UAUGGGGCUUCUGUAGAGAUUUC |34
Evidence Experimental
Experiments Illumina
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1229940041 1 dbSNP
rs1184422098 2 dbSNP
rs768029583 3 dbSNP
rs202014433 6 dbSNP
rs774834919 7 dbSNP
rs1484376029 8 dbSNP
rs771338088 8 dbSNP
rs749521347 10 dbSNP
rs773421450 12 dbSNP
rs1250672393 14 dbSNP
rs769780471 15 dbSNP
rs781028022 16 dbSNP
rs1315377622 17 dbSNP
rs754885466 18 dbSNP
rs746860289 20 dbSNP
rs1330333643 23 dbSNP
Putative Targets

miRNA Expression profile
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol DUSP18   
Synonyms DSP18, DUSP20, LMWDSP20
Description dual specificity phosphatase 18
Transcript NM_152511   
Expression
Putative miRNA Targets on DUSP18
3'UTR of DUSP18
(miRNA target sites are highlighted)		 
>DUSP18|NM_152511|3'UTR
   1 GCCATCCCACGAGCCCCTGCATTGGAGTCAGAGGTACAGATCTATTGTTGATCTTACACCAAGATCCAAACTTGAACATT
  81 CTACTTTTGTTGATACAGAAAAAAACAGATGATGCCTTTTATGAGCACAAAAAAGAGTTGCTGTAGCTTTTAACTTTATA
 161 ATCCATTTTTTTTAAGATTAAACTAATTGTGAGATGGTGAAGATAAATTTTCTGCCCTGTGAGTGACACTGGCCAGGGGA
 241 TAGGTTGAGGCAGATGGTGCCCAGAAGAAAGAGGGCAGCACCCATTGCACATGGCAGGCCTGGAATCCTGCAGCCCTCCC
 321 CAAAAACAGATTGACCCAGGAATGAATCTGCTACAATTCCACCTCATTCTTTCACACCCAGAGCCAGAGCCTTAAGCATC
 401 ATGGTACCTCTTGCGCTTCTTACAGTGAGTGCCAATCTACTAGATAAATGGCCTTCAGGCAGTGCTCCAGGAATCCTGGG
 481 GGGTCCCAGGCCACCTCTGCTTCCACCTTCACTATAAGTGGCCCAGTTCTGGTTTTCTAGATTGTACTTATGCATAAGAT
 561 AGTTTTTAAAGAAAGCATTCCACTGTGTAAATTTTTTTTTGTCTTTTTTTGAAACTGTCCTGCTCTGTCACCCATCCTAG
 641 AGTGCAGTAGTGTGATCATGGCTCACTGTAGCCACAACCTCTCAGGCTCAAGTGATCCTCTTACCTTAGCCTCCTGCGTG
 721 GCTGGGACTACAGATGTTTGCCACCATGCCCGCCTCATTTTTTTTCTTTTTTTATAGAGATGAGATTTTACTATGTCGCC
 801 CAGACTGGTCTCAAACTCCTGGCCTCAAGCAATCCTCACGCCTCAGCCTCCCAAAGTGTTGATGAGCCACTGTACCCCGA
 881 TACCACTGTATAAAAAATTTAAAAAAAATTGTGAGTGCTATTGTACATGGCAAAGTTTCAAAGAGCTCTTGGCCATCCCT
 961 CACCAAACTTTGGCAAAAGATGGTGTTAGTCCCCTTCTCCAGGGCACATGAGAAAAACAGGCCTAACATCAGGTCTCAGC
1041 GGTTCCTCTCACAGGCCTTGGCTTGGAAGGCTGGAGCTTCGGACCAAGGCCCAGCCCTGTCACCTCCTCTTCATGTGATG
1121 TGGACCCCTGGGAGCATCAGTGTCCTCATCTGTCCAATGACAGCCCTTTTCTCACAGAGTTATTGTGAAGATTCAACAAT
1201 TTCTTGGCATAGTGCCTGGCACATGGTGTGTGCTTAGCGCAAATGGCAGCTCTCATCATGAATGATAGACTCTTTCACCC
1281 TGCTGGTCCCAGGTCGGCACACACATCCCCATAATGGCATTTCTCCTTTCTGTGCACAGCACTTTATTGTTACAAAGTAC
1361 TCTTCCAAAAAGTTACCCTGTGTGTAAAAAAAAAAAAAAAAAAAAATGGTTTAAGTCCTTTCAGACCCTACCTCACAGGA
1441 GGCCTAGACTTAGAGCCTTTTGAGAGCTTCCGTCTTGTTTAATCTAGGTGCAATCTAGAGGTCCTGAAACAAGGAGCACA
1521 GTTCCAGCTTCCCCCAATCACTTCTAAACAGTGACTGCAGCCTTGTTTAGAATCACTATGAAAACCTGCACCCCGGCTGA
1601 CTACTGGGATCCATAAGGGGGCCGTGTCAAAGGGACTAACTAGTGGACTCCATCAGTAGGCCCTGGAATTCAGGATTGTT
1681 CACATCCTCTTGGTGCCAAGGACCTGGCTGAAGACCAGCTCTTCTGATCCAGAGGTTTTCAGCAAACAGCATTTGAAACA
1761 AAAGCACAGCTGCTCTGTTTGACACCAAACTGTGGCTCCAGATTCCAGTAGAAGCCAAATGCTTTTTCTTTTAACAGCTG
1841 GGTGCCTGTAATCCCAGTTACTTGGGAGGCTGAGGCAGGAGAATTGCTTGAACCCAGGAGGCGGAGGTTGCAGTGAGCCG
1921 AGCTTGCACCATTGCACTCCAGCCTGGGCAACAAGAGTGAGACTCCATCTCAAAAAGAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' cuUUAGAGAU-GUCUU-----CGGGGUAu 5'
            :|| |:|: ||  |     |||:||| 
Target 5' caGATGTTTGCCACCATGCCCGCCTCATt 3'
 731 - 759 129.00 -10.87
2 
miRNA  3' cuUUAGAGAUGUCUUCGGGGUau 5'
            |||| ||: :|::|:||||  
Target 5' ggAATC-CTG-GGGGGTCCCAgg 3'
 470 - 490 127.00 -18.90
3 
miRNA  3' cuUUAGAGAUGUCU-UCGGGGUAu 5'
            ::||   ||| | | |||||| 
Target 5' caGGTCGGCACACACATCCCCATa 3'
 1290 - 1313 125.00 -13.40
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN13910233 10 COSMIC
COSN30525344 45 COSMIC
COSN30459143 67 COSMIC
COSN508005 98 COSMIC
COSN31503614 110 COSMIC
COSN31580107 162 COSMIC
COSN30676681 166 COSMIC
COSN24381060 173 COSMIC
COSN24297153 174 COSMIC
COSN28744376 174 COSMIC
COSN22687368 240 COSMIC
COSN22232250 454 COSMIC
COSN1260785 1492 COSMIC
COSN20661743 1715 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1243126083 1 dbSNP
rs780536202 4 dbSNP
rs1450102425 7 dbSNP
rs1292051248 8 dbSNP
rs756496468 9 dbSNP
rs371630116 10 dbSNP
rs1011008862 11 dbSNP
rs893879557 13 dbSNP
rs1230588462 17 dbSNP
rs1362394249 18 dbSNP
rs1052420769 21 dbSNP
rs1348072779 21 dbSNP
rs777330023 22 dbSNP
rs1433781963 27 dbSNP
rs1351287772 28 dbSNP
rs758100559 33 dbSNP
rs1428513952 36 dbSNP
rs1368232215 37 dbSNP
rs893125735 39 dbSNP
rs58619343 42 dbSNP
rs78592960 44 dbSNP
rs373502013 45 dbSNP
rs759046552 50 dbSNP
rs759310828 51 dbSNP
rs1045851006 53 dbSNP
rs1362188246 60 dbSNP
rs948975045 77 dbSNP
rs916130083 78 dbSNP
rs1413135500 87 dbSNP
rs1038581128 104 dbSNP
rs111803206 106 dbSNP
rs571380555 106 dbSNP
rs941743916 106 dbSNP
rs532504807 109 dbSNP
rs1263806179 112 dbSNP
rs1046320552 117 dbSNP
rs1333548710 124 dbSNP
rs1440932454 130 dbSNP
rs1279780622 135 dbSNP
rs1425047565 138 dbSNP
rs947939011 143 dbSNP
rs1279394958 144 dbSNP
rs983234091 144 dbSNP
rs1348481510 154 dbSNP
rs1213012466 157 dbSNP
rs1248504133 158 dbSNP
rs747420326 164 dbSNP
rs552648980 165 dbSNP
rs182765470 166 dbSNP
rs1048687783 173 dbSNP
rs2240002 174 dbSNP
rs923133666 174 dbSNP
rs1253650364 175 dbSNP
rs1396125575 187 dbSNP
rs1220002455 189 dbSNP
rs1490149295 209 dbSNP
rs1393615202 212 dbSNP
rs918331297 219 dbSNP
rs1292412845 220 dbSNP
rs1223761339 229 dbSNP
rs1337132867 231 dbSNP
rs529976634 232 dbSNP
rs1438325300 233 dbSNP
rs560958490 237 dbSNP
rs1306449445 238 dbSNP
rs1249559935 239 dbSNP
rs1338774591 240 dbSNP
rs1017575210 244 dbSNP
rs1224512594 250 dbSNP
rs561956840 251 dbSNP
rs1275262067 265 dbSNP
rs1467299609 271 dbSNP
rs1193311360 276 dbSNP
rs1253949672 279 dbSNP
rs1375839709 281 dbSNP
rs370093997 282 dbSNP
rs1191599289 288 dbSNP
rs1373037708 291 dbSNP
rs1404738808 303 dbSNP
rs191779581 310 dbSNP
rs912178934 312 dbSNP
rs987753570 316 dbSNP
rs1476049040 326 dbSNP
rs1167970564 336 dbSNP
rs1401923953 337 dbSNP
rs1459548788 354 dbSNP
rs1346624752 363 dbSNP
rs1324813574 369 dbSNP
rs1394873783 374 dbSNP
rs953733455 377 dbSNP
rs1293306127 397 dbSNP
rs1325759961 399 dbSNP
rs1228136183 406 dbSNP
rs1271996083 408 dbSNP
rs1332771814 414 dbSNP
rs1029184535 415 dbSNP
rs1452314440 423 dbSNP
rs989600900 425 dbSNP
rs527431568 435 dbSNP
rs1470072235 442 dbSNP
rs377191360 448 dbSNP
rs1261536101 449 dbSNP
rs998966511 455 dbSNP
rs907241080 467 dbSNP
rs1400874057 479 dbSNP
rs564589791 482 dbSNP
rs1473947622 483 dbSNP
rs1013072246 484 dbSNP
rs1163699836 484 dbSNP
rs1459161014 485 dbSNP
rs1196934705 493 dbSNP
rs894644226 514 dbSNP
rs1382645575 524 dbSNP
rs544614555 526 dbSNP
rs1358725086 527 dbSNP
rs1353586449 532 dbSNP
rs1479984300 533 dbSNP
rs1187045833 541 dbSNP
rs999534508 544 dbSNP
rs1337194613 552 dbSNP
rs879651012 553 dbSNP
rs1260504453 558 dbSNP
rs754666420 561 dbSNP
rs1207351505 581 dbSNP
rs575598848 582 dbSNP
rs62235876 589 dbSNP
rs1484877285 591 dbSNP
rs1025374090 594 dbSNP
rs1216618584 600 dbSNP
rs1425178437 601 dbSNP
rs908898058 601 dbSNP
rs941580231 601 dbSNP
rs1331419261 603 dbSNP
rs9606762 606 dbSNP
rs895041220 622 dbSNP
rs1454141142 625 dbSNP
rs923051047 631 dbSNP
rs368654453 632 dbSNP
rs1303911074 633 dbSNP
rs931129102 645 dbSNP
rs1313547421 648 dbSNP
rs1361893210 664 dbSNP
rs1287720072 677 dbSNP
rs896949101 678 dbSNP
rs1389824069 681 dbSNP
rs575063869 683 dbSNP
rs1317851345 684 dbSNP
rs150577166 684 dbSNP
rs373265082 684 dbSNP
rs1242812508 685 dbSNP
rs1278692526 688 dbSNP
rs1347766503 694 dbSNP
rs990094155 700 dbSNP
rs1173795931 713 dbSNP
rs41282549 717 dbSNP
rs1031672998 718 dbSNP
rs912247586 736 dbSNP
rs535220293 738 dbSNP
rs985510698 751 dbSNP
rs932286191 752 dbSNP
rs1024383729 763 dbSNP
rs1434023926 765 dbSNP
rs1187117052 766 dbSNP
rs1360908525 766 dbSNP
rs1466309433 774 dbSNP
rs922177113 779 dbSNP
rs1012936241 782 dbSNP
rs1374294299 784 dbSNP
rs1449345120 787 dbSNP
rs566183604 789 dbSNP
rs188894312 791 dbSNP
rs1370718106 797 dbSNP
rs559056017 798 dbSNP
rs1005805888 801 dbSNP
rs1313399124 806 dbSNP
rs1225711664 816 dbSNP
rs376083231 816 dbSNP
rs958208800 819 dbSNP
rs539054014 825 dbSNP
rs868780895 832 dbSNP
rs1047303839 836 dbSNP
rs929005618 838 dbSNP
rs755332513 839 dbSNP
rs978168487 840 dbSNP
rs971203255 846 dbSNP
rs1194130341 847 dbSNP
rs570092289 852 dbSNP
rs368028374 853 dbSNP
rs1427225861 857 dbSNP
rs901492279 861 dbSNP
rs553355078 863 dbSNP
rs1040174478 875 dbSNP
rs184032553 878 dbSNP
rs1012652190 879 dbSNP
rs1324147808 884 dbSNP
rs910403543 885 dbSNP
rs895101162 896 dbSNP
rs550131747 900 dbSNP
rs139004951 901 dbSNP
rs1360463988 908 dbSNP
rs1294226315 909 dbSNP
rs566901409 909 dbSNP
rs1304315222 911 dbSNP
rs1460284113 915 dbSNP
rs1220030167 918 dbSNP
rs1372358170 920 dbSNP
rs567546900 926 dbSNP
rs1171048645 931 dbSNP
rs547276503 941 dbSNP
rs1451311206 955 dbSNP
rs1467835709 959 dbSNP
rs1221996404 961 dbSNP
rs897003052 963 dbSNP
rs527443314 964 dbSNP
rs1484847201 965 dbSNP
rs1185861342 968 dbSNP
rs1420238670 977 dbSNP
rs1383413762 983 dbSNP
rs190940171 985 dbSNP
rs977363174 987 dbSNP
rs1417378806 988 dbSNP
rs370995187 1002 dbSNP
rs890856423 1004 dbSNP
rs1049445520 1009 dbSNP
rs1194361497 1013 dbSNP
rs1480503289 1016 dbSNP
rs932311832 1018 dbSNP
rs1325925779 1019 dbSNP
rs1252306149 1021 dbSNP
rs9609038 1030 dbSNP
rs1357968227 1035 dbSNP
rs1340545637 1040 dbSNP
rs531285897 1041 dbSNP
rs991551600 1042 dbSNP
rs185920559 1048 dbSNP
rs1228593204 1057 dbSNP
rs924136861 1073 dbSNP
rs1291758241 1075 dbSNP
rs978219288 1081 dbSNP
rs1214921866 1083 dbSNP
rs1263850240 1085 dbSNP
rs970869375 1087 dbSNP
rs1185871903 1092 dbSNP
rs1314428676 1095 dbSNP
rs1165224634 1099 dbSNP
rs542599421 1106 dbSNP
rs917990971 1118 dbSNP
rs990877892 1120 dbSNP
rs1160418578 1121 dbSNP
rs1400515962 1121 dbSNP
rs959642714 1123 dbSNP
rs1413531514 1124 dbSNP
rs1310532335 1129 dbSNP
rs114734655 1134 dbSNP
rs1308439390 1138 dbSNP
rs145135259 1142 dbSNP
rs1363650503 1151 dbSNP
rs1285614918 1157 dbSNP
rs998436645 1161 dbSNP
rs961265076 1163 dbSNP
rs1162933267 1164 dbSNP
rs58640678 1171 dbSNP
rs1445310067 1173 dbSNP
rs775755888 1175 dbSNP
rs541276943 1178 dbSNP
rs1208722136 1180 dbSNP
rs901519950 1182 dbSNP
rs374825925 1193 dbSNP
rs1008476578 1199 dbSNP
rs1189822324 1204 dbSNP
rs1231426025 1206 dbSNP
rs1469854160 1207 dbSNP
rs370605383 1208 dbSNP
rs888832950 1216 dbSNP
rs1054203156 1218 dbSNP
rs1049951541 1222 dbSNP
rs996581534 1225 dbSNP
rs1251640157 1226 dbSNP
rs924450216 1228 dbSNP
rs9606761 1231 dbSNP
rs1352374909 1232 dbSNP
rs1054033668 1233 dbSNP
rs373828068 1238 dbSNP
rs936955524 1239 dbSNP
rs1489986972 1255 dbSNP
rs1231917252 1261 dbSNP
rs1302612411 1268 dbSNP
rs1291698148 1270 dbSNP
rs1202217104 1274 dbSNP
rs949948572 1275 dbSNP
rs1437452493 1280 dbSNP
rs924189206 1288 dbSNP
rs1240344047 1293 dbSNP
rs1193513400 1295 dbSNP
rs1356424414 1296 dbSNP
rs1479316567 1298 dbSNP
rs917251872 1304 dbSNP
rs181287363 1305 dbSNP
rs8630 1309 dbSNP
rs958691621 1329 dbSNP
rs1334822615 1332 dbSNP
rs1402141511 1335 dbSNP
rs1438483200 1336 dbSNP
rs556329536 1338 dbSNP
rs536602349 1347 dbSNP
rs984205770 1349 dbSNP
rs1411432989 1352 dbSNP
rs1268492454 1353 dbSNP
rs1343478966 1363 dbSNP
rs752605804 1375 dbSNP
rs1302456105 1379 dbSNP
rs1376644295 1384 dbSNP
rs1304393986 1385 dbSNP
rs3067260 1386 dbSNP
rs1156930178 1395 dbSNP
rs549480509 1398 dbSNP
rs868714994 1401 dbSNP
rs1412994071 1402 dbSNP
rs1184705247 1404 dbSNP
rs386395203 1406 dbSNP
rs918056035 1406 dbSNP
rs1391273646 1407 dbSNP
rs1425291282 1407 dbSNP
rs1459591452 1407 dbSNP
rs1491130046 1407 dbSNP
rs33914926 1407 dbSNP
rs77182933 1407 dbSNP
rs1387905236 1408 dbSNP
rs1488927444 1409 dbSNP
rs1025780866 1410 dbSNP
rs1193729059 1411 dbSNP
rs1264778655 1413 dbSNP
rs1474021177 1422 dbSNP
rs1163646136 1432 dbSNP
rs190122162 1436 dbSNP
rs540145024 1437 dbSNP
rs965578654 1438 dbSNP
rs1420288901 1444 dbSNP
rs955979854 1447 dbSNP
rs1263855606 1466 dbSNP
rs1353649002 1470 dbSNP
rs919948525 1471 dbSNP
rs113483027 1472 dbSNP
rs1054636528 1473 dbSNP
rs1237296594 1473 dbSNP
rs1260556649 1487 dbSNP
rs999935336 1493 dbSNP
rs1453880231 1496 dbSNP
rs1219521451 1497 dbSNP
rs144406312 1502 dbSNP
rs1041512921 1506 dbSNP
rs1180876246 1510 dbSNP
rs1256464040 1511 dbSNP
rs1202864452 1532 dbSNP
rs771497337 1533 dbSNP
rs961318449 1537 dbSNP
rs917199305 1541 dbSNP
rs1440163644 1542 dbSNP
rs747410659 1550 dbSNP
rs1160397904 1553 dbSNP
rs773642436 1554 dbSNP
rs1055637636 1557 dbSNP
rs937367910 1561 dbSNP
rs1008111179 1570 dbSNP
rs955398354 1573 dbSNP
rs1308987156 1576 dbSNP
rs1229909934 1584 dbSNP
rs1028135735 1588 dbSNP
rs1282441930 1589 dbSNP
rs116386177 1594 dbSNP
rs892876631 1595 dbSNP
rs1208783904 1597 dbSNP
rs1332784100 1603 dbSNP
rs1054085204 1621 dbSNP
rs186145267 1623 dbSNP
rs1237277725 1624 dbSNP
rs1440101033 1627 dbSNP
rs533761206 1640 dbSNP
rs1393158873 1642 dbSNP
rs1432572629 1652 dbSNP
rs376458022 1654 dbSNP
rs951470764 1658 dbSNP
rs918750444 1672 dbSNP
rs976883011 1677 dbSNP
rs141040023 1683 dbSNP
rs1468483021 1697 dbSNP
rs902814928 1700 dbSNP
rs1367496234 1705 dbSNP
rs1043038581 1708 dbSNP
rs1007129323 1714 dbSNP
rs1301272979 1722 dbSNP
rs181701741 1727 dbSNP
rs76352804 1729 dbSNP
rs1479255068 1733 dbSNP
rs1257066179 1741 dbSNP
rs1000356204 1743 dbSNP
rs1240866344 1747 dbSNP
rs1055280041 1748 dbSNP
rs938122936 1759 dbSNP
rs562602773 1765 dbSNP
rs548706853 1766 dbSNP
rs1488115774 1769 dbSNP
rs920000791 1778 dbSNP
rs1193175592 1780 dbSNP
rs1269484231 1783 dbSNP
rs1426840322 1788 dbSNP
rs1464036508 1795 dbSNP
rs1424571727 1798 dbSNP
rs974114686 1805 dbSNP
rs1248157578 1818 dbSNP
rs1349666584 1819 dbSNP
rs1014082792 1828 dbSNP
rs202024432 1829 dbSNP
rs200849606 1833 dbSNP
rs199884774 1834 dbSNP
rs895636760 1834 dbSNP
rs11325761 1835 dbSNP
rs398101724 1835 dbSNP
rs9609037 1840 dbSNP
rs1220160601 1841 dbSNP
rs1346956994 1843 dbSNP
rs908515442 1848 dbSNP
rs1320906141 1856 dbSNP
rs1222157812 1863 dbSNP
rs1268343135 1867 dbSNP
rs1487293687 1870 dbSNP
rs937233624 1881 dbSNP
rs987141936 1884 dbSNP
rs1478884832 1885 dbSNP
rs1365997614 1886 dbSNP
rs955301597 1890 dbSNP
rs1406348410 1894 dbSNP
rs1048349534 1898 dbSNP
rs1028605503 1899 dbSNP
rs930057822 1900 dbSNP
rs1419685236 1903 dbSNP
rs975267632 1904 dbSNP
rs1322696353 1911 dbSNP
rs918712548 1915 dbSNP
rs190148042 1919 dbSNP
rs1405635289 1920 dbSNP
rs1282094478 1921 dbSNP
rs1378124729 1922 dbSNP
rs1335190855 1925 dbSNP
rs1291826152 1927 dbSNP
rs1416512339 1928 dbSNP
rs1417883519 1930 dbSNP
rs1351410116 1931 dbSNP
rs1032723119 1932 dbSNP
rs1215809505 1933 dbSNP
rs766654414 1935 dbSNP
rs965559343 1936 dbSNP
rs998524480 1937 dbSNP
rs1167818975 1939 dbSNP
rs1450679780 1940 dbSNP
rs148129737 1943 dbSNP
rs985722490 1948 dbSNP
rs187497355 1951 dbSNP
rs1459656233 1952 dbSNP
rs1236539865 1955 dbSNP
rs1439551240 1955 dbSNP
rs1159801148 1958 dbSNP
rs1360553433 1959 dbSNP
rs958275306 1962 dbSNP
rs1331679177 1963 dbSNP
rs1358198822 1967 dbSNP
rs1448381764 1967 dbSNP
rs1210471553 1971 dbSNP
rs1374398120 1972 dbSNP
rs1443918642 1975 dbSNP
rs146820373 1977 dbSNP
rs1195127809 1978 dbSNP
rs1342826777 1981 dbSNP
rs1299860426 1982 dbSNP
rs1278077720 1983 dbSNP
rs1443210536 1985 dbSNP
rs572758556 1987 dbSNP
rs878868331 1987 dbSNP
rs978485848 1988 dbSNP
rs1243872942 1989 dbSNP
rs1382208654 1990 dbSNP
rs967446995 1992 dbSNP
rs1020017031 1993 dbSNP
rs1403799881 1993 dbSNP
rs1414622432 1993 dbSNP
rs1491057586 1993 dbSNP
rs375019336 1993 dbSNP
rs397723342 1993 dbSNP
rs555969142 1993 dbSNP
rs56242112 1993 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions TZM-bl
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM1462574. RNA binding protein: AGO2. Condition:TZM-bl ami BaL ...

- Whisnant AW; Bogerd HP; Flores O; Ho P; et al., 2013, mBio.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' cuuuagagaUGUCU-UCGGGGUAu 5'
                   ||| | | |||||| 
Target 5' --------cACACACAUCCCCAUa 3'
 		1 - 16
Article - Whisnant AW; Bogerd HP; Flores O; Ho P; et al.
- mBio, 2013
UNLABELLED: The question of how HIV-1 interfaces with cellular microRNA (miRNA) biogenesis and effector mechanisms has been highly controversial. Here, we first used deep sequencing of small RNAs present in two different infected cell lines (TZM-bl and C8166) and two types of primary human cells (CD4(+) peripheral blood mononuclear cells [PBMCs] and macrophages) to unequivocally demonstrate that HIV-1 does not encode any viral miRNAs. Perhaps surprisingly, we also observed that infection of T cells by HIV-1 has only a modest effect on the expression of cellular miRNAs at early times after infection. Comprehensive analysis of miRNA binding to the HIV-1 genome using the photoactivatable ribonucleoside-induced cross-linking and immunoprecipitation (PAR-CLIP) technique revealed several binding sites for cellular miRNAs, a subset of which were shown to be capable of mediating miRNA-mediated repression of gene expression. However, the main finding from this analysis is that HIV-1 transcripts are largely refractory to miRNA binding, most probably due to extensive viral RNA secondary structure. Together, these data demonstrate that HIV-1 neither encodes viral miRNAs nor strongly influences cellular miRNA expression, at least early after infection, and imply that HIV-1 transcripts have evolved to avoid inhibition by preexisting cellular miRNAs by adopting extensive RNA secondary structures that occlude most potential miRNA binding sites. IMPORTANCE: MicroRNAs (miRNAs) are a ubiquitous class of small regulatory RNAs that serve as posttranscriptional regulators of gene expression. Previous work has suggested that HIV-1 might subvert the function of the cellular miRNA machinery by expressing viral miRNAs or by dramatically altering the level of cellular miRNA expression. Using very sensitive approaches, we now demonstrate that neither of these ideas is in fact correct. Moreover, HIV-1 transcripts appear to largely avoid regulation by cellular miRNAs by adopting an extensive RNA secondary structure that occludes the ability of cellular miRNAs to interact with viral mRNAs. Together, these data suggest that HIV-1, rather than seeking to control miRNA function in infected cells, has instead evolved a mechanism to become largely invisible to cellular miRNA effector mechanisms.
LinkOut: [PMID: 23592263]
CLIP-seq Support 1 for dataset GSM1462574
Method / RBP PAR-CLIP / AGO2
Cell line / Condition TZM-bl / TZM-bl ami BaL
Location of target site ENST00000403268.1 | 3UTR | CACACACAUCCCCAUAAUGGCAUUUCUCCUUUCUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23592263 / GSE59944
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
32 hsa-miR-3675-5p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT366903 NONO non-POU domain containing octamer binding 2 2
MIRT453894 DUSP18 dual specificity phosphatase 18 2 2
MIRT461725 ZNF426 zinc finger protein 426 2 2
MIRT464694 UBE2V1 ubiquitin conjugating enzyme E2 V1 2 2
MIRT465957 TMEM189-UBE2V1 TMEM189-UBE2V1 readthrough 2 2
MIRT466038 TMEM189 transmembrane protein 189 2 2
MIRT471546 PAX5 paired box 5 2 2
MIRT472813 MTMR12 myotubularin related protein 12 2 2
MIRT474099 LMBR1L limb development membrane protein 1 like 2 2
MIRT480205 CAD carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase 2 2
MIRT488268 HSP90AB1 heat shock protein 90 alpha family class B member 1 2 8
MIRT491222 MRPL34 mitochondrial ribosomal protein L34 2 2
MIRT494768 AP1G1 adaptor related protein complex 1 gamma 1 subunit 2 2
MIRT497228 MORC2 MORC family CW-type zinc finger 2 2 2
MIRT501676 PFN1 profilin 1 2 6
MIRT511831 H2AFX H2A histone family member X 2 4
MIRT513880 HNRNPUL1 heterogeneous nuclear ribonucleoprotein U like 1 2 4
MIRT519402 DNASE2 deoxyribonuclease 2, lysosomal 2 4
MIRT522627 MAP7D1 MAP7 domain containing 1 2 4
MIRT546998 PPP2CA protein phosphatase 2 catalytic subunit alpha 2 2
MIRT555119 PUM2 pumilio RNA binding family member 2 2 2
MIRT560380 TIMM8A translocase of inner mitochondrial membrane 8A 2 2
MIRT572188 CDADC1 cytidine and dCMP deaminase domain containing 1 2 2
MIRT634822 ASB6 ankyrin repeat and SOCS box containing 6 2 2
MIRT641149 DNMBP dynamin binding protein 2 2
MIRT647389 ZNF616 zinc finger protein 616 2 2
MIRT670851 SFT2D2 SFT2 domain containing 2 2 2
MIRT698600 TEX261 testis expressed 261 2 2
MIRT698691 TBPL1 TATA-box binding protein like 1 2 2
MIRT708725 PTPLAD2 3-hydroxyacyl-CoA dehydratase 4 1 1
MIRT718340 SYNDIG1L synapse differentiation inducing 1 like 2 2
MIRT725514 FBXO46 F-box protein 46 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-3675 Doxorubicin 31703 NSC123127 approved sensitive High Triple-Negative Breast Cancer cell line (MDA-MB-231, MDA-MB-468)
hsa-miR-3675-5p Cisplatin 5460033 NSC119875 approved resistant cell line (MGC-803)
hsa-miR-3675-5p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)

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