miRTarBase - #MIRT454128


—
pre-miRNA Information
pre-miRNA hsa-mir-6737   
Genomic Coordinates chr1: 153962351 - 153962420
Description Homo sapiens miR-6737 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-6737-5p
Sequence 6| UUGGGGUGGUCGGCCCUGGAG |26
Evidence Experimental
Experiments Meta-analysis
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs766338599 4 dbSNP
rs765728788 7 dbSNP
rs757341439 9 dbSNP
rs539511149 11 dbSNP
rs764259486 12 dbSNP
rs988937601 21 dbSNP
Putative Targets

Gene Information
Gene Symbol FOXRED2   
Synonyms ERFAD
Description FAD dependent oxidoreductase domain containing 2
Transcript NM_001102371   
Other Transcripts NM_024955   
Expression
Putative miRNA Targets on FOXRED2
3'UTR of FOXRED2
(miRNA target sites are highlighted)		 
>FOXRED2|NM_001102371|3'UTR
   1 CTGTCCCTTCCTAAGCTGTGGGCACAGTGGCCAGGCCTCCCCACCTAGGCCCATGGTCAGTCCCTCTTTCCCCGCAACCT
  81 CACACTCCCGCCAATGCGTGATTGCCAAAGACCACTCAGATCATGGCAGTGTCTGCAGCAAAGCCACCAGATGGCACGTG
 161 AGGGCTGAAAGTCGGGGATGCGGTGGTCTCCTCCCTCCTGTCAGGGGGCAGAAGGGCATCCTCTGCCAGGTGGGAGCTGC
 241 CTTCCCCAGCCCAGTTTGTCTGCAATGGAGCTGTCGCTGAGCCCCAGGCCAGCCCAGTTCTGCCCCGTCTCAAGTGCTCC
 321 TCTTCCTTCCAAGCCCCTCCTCAGATGGGCCTGCATCCCGCCTGTGGAGTGCTTCACAGGGGAAACCCATCCGCATCTTA
 401 AGAGTTTGTGGCAAGCGCTTTAAAACAAAAGCTCTGATATCCTCAACAACCACAATGGGCAGGTGGGATTGTTGCCCCAG
 481 ATGACTGCTGAAGACACCAGCTGTGGGATGTCAAGTAATTCCAGGGACCCCCAGCTGGGAGTCCCCGTCTGTGTCACTTG
 561 CCACACACTGCCTCAACCTCCCCGCCCCATTTTCAGCAGGGTTTGGGCTTAGCTACAGAGCCCAAGAGGGTCAGCCCTGC
 641 TTATCATCATAGGCCCAGCAGGCTGATCTCGAGCAGCGATAGGACAGCTCCCTGCAAAGCCATCTTAGCAACTTTCTCAC
 721 TGAGAAGCAGGATTCAGAGCTGCTCTCCCCAGTTGCACCCCCTGACTCATCTTCCAGCTGGCTCTTCTCTCCCATCCTAC
 801 TCCCTTCTGTCTCCCTGCCCTCTGCCATCCTGAACCATGCCTTGCTTCTAACCTGCCTGGTCAAGTTTTGTGAAACTTAT
 881 CCTGCTGTCTCGGGCTGGCACCCATATGTGCTCACCATGTGTAAGGTGACATTTCCAAATGCCTTTGTGTGATAATGATG
 961 ATGAATTTGGTTCCTAGTCTCTTCTTCATTGCCCTTCCTCACCAGCAATCTGCACTTTCCCATCAGGCGTCTTAGTCTCA
1041 TTTGTAAGTGCATAAGATAATCACAGTGATTTTTCAAAGCCCAGGATCATAAGTGATTGCTTTTTCACTGGTTCTTACTA
1121 ACTCTTCATGTATCCACTCAGAATTCCAAGGACAATCCCAGCACTCTGGGAGGCCCAGGCAGGTGGATCACCTGAGGTCA
1201 GGAGTTTGAGACCAGCCTGACCAACATGGAGAAACCCTATCTCTACTAAAAATACAAAACTAGCCAGGCGTGGTAGCACA
1281 TGTCTATAATCCCAGCTACTGGAGAGGCTGAGGCAGGAGAATCACTTAAACCCGGGAGGCAGAGGTTGCAGTGAGCCGAG
1361 ATTGCGCCATTGCACTCCAGCCTAGGTAACAAGAGGGAAACTCCATCTCAAAAAATAAGTTAATTAAATTAAATTAAAAT
1441 AAAACATGCGCTGGGTACAGTTGCTTACACCTGTAATCCCAGCACTTTGGGAGGCCAAAGTGGGCCGATCACCTGAGCTC
1521 AGGAATTCGAGACCAGCCTGGCCAACATAGCAAAACCTTGTCTCTACTAACGGTAAAAAAAATTAGCTGGGCATGGTGGA
1601 GCATGCCTGTCATCCCAGCTACTTGGGAAGCTGAGGCAGGAGAATTGCTTGAACCTGGGAGGTGGAGGTTGCAGTGAGCA
1681 GAGACCGAGCCACTGTACTCCAGCCTAGGTGACAAAGCAAGACCCACAGTAAAGCCCCCACACCCCATCTCAAAAAAATA
1761 AAAAATAAAAAAGAACAAAGTATGCTACAACAAAAGTGAAAAGAGAAAAAGAATTCCAAGAACCCGGGCTTTCTGGATCC
1841 AAAGCTCTTTCATGGGGACGTCCTCTTCCCCTCTTGGCTTGGTCCAGACTTTTTCTTTTTCTTTTTTTTTTTTTTTGCAA
1921 TGGATTTCGCTCTTGTCACCCAGGCTGGAGTGCAATGGCACGATGTCGGCTCACTGCAACTTCTGCCTCCCGGGTCTAAA
2001 CAATTCTCTTCCCTCAACCTCCCAAGTAGCTGGGATTACAAGCGCCTGCCACCACGCCCAGCTAATTTTTGTATTTTTAG
2081 TAGAGACAGGGTTTCACCACATTGGCCAGGCTGGTCTCGAACTCCTGACCTCAGGTGATCCACCTGTCTTGGCCTCCTAA
2161 AGTGTTGGGATTACAGGCATGAGCCACCACGCTCGGCCCAGTCCAGACTTTTTAACTACCTGGCCCCACTGCAGACACAG
2241 TTCCCTCTAGTCCTTCCCAGAGTTACAAGAAGAGAACTCCAGTAGCCTTATTCTGTCAGGGACGAATTGTTTACCCCATG
2321 ATAATGTAGGATATCATAAATTCTTCTTCAAAGGTTTTAGCCTGTAATTTGTTAAGTACATTGAGTTCTGAGATCCTCTC
2401 CAAAGAACCAATGTATCAGTATGTTCAGCTCACCTGTTCTTTGTTCTTCATTTTAACTTTTAATTTCCTCATTCTTTATG
2481 TCTCCTTGCCCCTAGTTTCAGTAAACAATCCCCTCCTAGCCTCTGTCACCTGCTCTGACCTGAGTCACCTTTAGTCACCT
2561 GGTCCGTAACCATCTTTCCTGTCTAAACTTCTCACCCCACCACTCTGGCTTATACCCCTGCTCTCTTTAAAATAGCCAGT
2641 CAGAATTAGCTTAGATTGTGCGGTCCAACCCTAGCCCATAGGGGAACAACACAGCAGTAGGGGGTACCTGCATCAGGGAT
2721 AAGAACCCATTCCCCTCCCTTGTTCCGGTGTGCTCTCGCCATTGCACCATCCATGAGACGCACTCTTGTATAGAAGTAAA
2801 ATTGCCTTGCTGAGAAAATGTAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' gaggUCCCGGCUGGUGGGGUu 5'
              ||  || | ||||||| 
Target 5' gtaaAGCCCCCA-CACCCCAt 3'
 1729 - 1748 148.00 -16.30
2 
miRNA  3' gaGGUCCCGGCU-----GGUGGGGUu 5'
            :||||| |||     ::|||||| 
Target 5' tgTCAGGGACGAATTGTTTACCCCAt 3'
 2294 - 2319 147.00 -24.40
3 
miRNA  3' gaggucccggcuGGUGGGGUu 5'
                      :||||||| 
Target 5' tgtctaaacttcTCACCCCAc 3'
 2580 - 2600 141.00 -14.10
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN17168993 6 COSMIC
COSN30657462 34 COSMIC
COSN18743936 73 COSMIC
COSN30100989 89 COSMIC
COSN31557169 90 COSMIC
COSN31491152 167 COSMIC
COSN20242359 980 COSMIC
COSN5455716 1229 COSMIC
COSN25674891 1790 COSMIC
COSN17980107 2116 COSMIC
COSN8018139 2366 COSMIC
COSN31961971 2390 COSMIC
COSN17182639 2751 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1372623989 6 dbSNP
rs768339873 7 dbSNP
rs1226809342 8 dbSNP
rs1289512739 11 dbSNP
rs1318877615 16 dbSNP
rs372741355 25 dbSNP
rs1263024189 26 dbSNP
rs1199157477 31 dbSNP
rs765641805 36 dbSNP
rs1489951491 40 dbSNP
rs775291123 42 dbSNP
rs752555678 43 dbSNP
rs769516337 43 dbSNP
rs1222837147 45 dbSNP
rs774478648 46 dbSNP
rs745675765 48 dbSNP
rs1313906690 52 dbSNP
rs1011367241 65 dbSNP
rs190244720 73 dbSNP
rs906644566 74 dbSNP
rs964942666 79 dbSNP
rs1397902107 84 dbSNP
rs1018178545 88 dbSNP
rs1334823566 89 dbSNP
rs536926869 90 dbSNP
rs1012398173 94 dbSNP
rs1341304812 95 dbSNP
rs1342678122 97 dbSNP
rs1279633622 98 dbSNP
rs1317745266 102 dbSNP
rs890732509 115 dbSNP
rs763488270 117 dbSNP
rs867715390 123 dbSNP
rs1295835033 141 dbSNP
rs527536576 143 dbSNP
rs185348350 149 dbSNP
rs1416142352 152 dbSNP
rs1360219000 156 dbSNP
rs773502734 157 dbSNP
rs551341521 158 dbSNP
rs1048666645 161 dbSNP
rs1475000971 163 dbSNP
rs1172952344 166 dbSNP
rs1413109693 173 dbSNP
rs531657469 174 dbSNP
rs562837902 181 dbSNP
rs770238548 182 dbSNP
rs1333538829 185 dbSNP
rs867003363 186 dbSNP
rs918813258 191 dbSNP
rs571490858 198 dbSNP
rs944365685 202 dbSNP
rs572310100 205 dbSNP
rs911670270 206 dbSNP
rs149062122 226 dbSNP
rs1200428342 234 dbSNP
rs1278970460 256 dbSNP
rs1488367382 259 dbSNP
rs927898027 263 dbSNP
rs953229766 265 dbSNP
rs915077983 274 dbSNP
rs989292551 275 dbSNP
rs192126996 276 dbSNP
rs1172986971 278 dbSNP
rs965139379 285 dbSNP
rs1421668749 299 dbSNP
rs1296422482 300 dbSNP
rs1030858873 303 dbSNP
rs1384469605 306 dbSNP
rs1387596604 307 dbSNP
rs367598201 311 dbSNP
rs1275955417 316 dbSNP
rs1329762125 317 dbSNP
rs1440682537 323 dbSNP
rs988061337 326 dbSNP
rs1310722035 338 dbSNP
rs1356475121 349 dbSNP
rs540812562 357 dbSNP
rs137960935 360 dbSNP
rs779583787 369 dbSNP
rs1349449224 371 dbSNP
rs1210100582 389 dbSNP
rs1379337245 392 dbSNP
rs56929381 393 dbSNP
rs1192926657 402 dbSNP
rs2281085 403 dbSNP
rs896857917 416 dbSNP
rs187308382 417 dbSNP
rs1363340364 425 dbSNP
rs1005322944 427 dbSNP
rs555721595 431 dbSNP
rs1165282778 446 dbSNP
rs1332493926 448 dbSNP
rs1389025554 455 dbSNP
rs2281084 456 dbSNP
rs897295991 457 dbSNP
rs1041233804 460 dbSNP
rs939194667 463 dbSNP
rs1315858603 464 dbSNP
rs567016067 465 dbSNP
rs184089511 467 dbSNP
rs944423155 469 dbSNP
rs1266909312 479 dbSNP
rs191525802 490 dbSNP
rs911649177 493 dbSNP
rs1050212256 494 dbSNP
rs1258505470 503 dbSNP
rs1459011466 508 dbSNP
rs563712922 511 dbSNP
rs756980980 514 dbSNP
rs931630742 520 dbSNP
rs1181168177 521 dbSNP
rs1189716435 531 dbSNP
rs914940601 544 dbSNP
rs989786345 546 dbSNP
rs1461145543 547 dbSNP
rs571328160 547 dbSNP
rs1199006321 555 dbSNP
rs923741692 558 dbSNP
rs1457205312 567 dbSNP
rs1255746132 571 dbSNP
rs767786655 576 dbSNP
rs551570137 581 dbSNP
rs538123058 584 dbSNP
rs773496357 584 dbSNP
rs970747866 586 dbSNP
rs1311430929 589 dbSNP
rs1396038196 589 dbSNP
rs1314264157 607 dbSNP
rs1353140277 609 dbSNP
rs1023671973 613 dbSNP
rs1227058085 614 dbSNP
rs1319804319 624 dbSNP
rs990897206 626 dbSNP
rs952700506 633 dbSNP
rs1250628961 634 dbSNP
rs36073262 634 dbSNP
rs1483546246 637 dbSNP
rs915270006 642 dbSNP
rs1254202554 646 dbSNP
rs1474984152 649 dbSNP
rs1426209812 663 dbSNP
rs569203450 670 dbSNP
rs1027008603 671 dbSNP
rs1379736891 672 dbSNP
rs1310685345 673 dbSNP
rs1446508968 674 dbSNP
rs1373146574 675 dbSNP
rs1398569033 675 dbSNP
rs994801850 677 dbSNP
rs145344272 678 dbSNP
rs1298504781 680 dbSNP
rs1349321690 683 dbSNP
rs1212533830 698 dbSNP
rs1294613783 702 dbSNP
rs910637489 703 dbSNP
rs1020164289 726 dbSNP
rs529346331 728 dbSNP
rs140682284 733 dbSNP
rs1485416614 735 dbSNP
rs1050161788 752 dbSNP
rs546728789 753 dbSNP
rs1217617707 761 dbSNP
rs1265526466 763 dbSNP
rs111233587 764 dbSNP
rs1186244206 764 dbSNP
rs761769072 764 dbSNP
rs146836520 792 dbSNP
rs149857268 793 dbSNP
rs377500775 794 dbSNP
rs751632676 804 dbSNP
rs1392719510 812 dbSNP
rs1053470674 814 dbSNP
rs935210964 819 dbSNP
rs923882949 821 dbSNP
rs1236148385 822 dbSNP
rs1428256593 829 dbSNP
rs544120653 830 dbSNP
rs141072379 840 dbSNP
rs1016491349 853 dbSNP
rs1388428212 855 dbSNP
rs766463506 870 dbSNP
rs1347065857 879 dbSNP
rs1240893114 880 dbSNP
rs894775642 887 dbSNP
rs1218710407 888 dbSNP
rs1215399237 890 dbSNP
rs763396510 891 dbSNP
rs990844660 892 dbSNP
rs2564 896 dbSNP
rs1287290332 904 dbSNP
rs1252860757 906 dbSNP
rs1240083338 907 dbSNP
rs1027370103 913 dbSNP
rs972764212 917 dbSNP
rs906405807 926 dbSNP
rs1303905557 940 dbSNP
rs1387750745 941 dbSNP
rs1398569078 942 dbSNP
rs1157992200 954 dbSNP
rs1367145571 957 dbSNP
rs1459187308 958 dbSNP
rs961888117 969 dbSNP
rs1019859102 971 dbSNP
rs1042185592 976 dbSNP
rs1447461941 988 dbSNP
rs187485790 988 dbSNP
rs1401919671 992 dbSNP
rs765705179 1001 dbSNP
rs1410059845 1002 dbSNP
rs1223427281 1015 dbSNP
rs562087988 1022 dbSNP
rs542129256 1028 dbSNP
rs3747163 1029 dbSNP
rs1272982534 1035 dbSNP
rs1458584037 1037 dbSNP
rs995898544 1049 dbSNP
rs1181104479 1050 dbSNP
rs553753862 1052 dbSNP
rs372730077 1081 dbSNP
rs16996797 1089 dbSNP
rs902210982 1095 dbSNP
rs1433604792 1120 dbSNP
rs1046285688 1122 dbSNP
rs370405615 1128 dbSNP
rs1466065545 1136 dbSNP
rs1333362534 1149 dbSNP
rs768462212 1151 dbSNP
rs1488954238 1153 dbSNP
rs1441495265 1159 dbSNP
rs1284880885 1162 dbSNP
rs1381571418 1170 dbSNP
rs1231734680 1186 dbSNP
rs545028820 1192 dbSNP
rs746649267 1198 dbSNP
rs9607349 1201 dbSNP
rs1201066443 1208 dbSNP
rs931353495 1211 dbSNP
rs755838961 1225 dbSNP
rs973265300 1227 dbSNP
rs1352112243 1230 dbSNP
rs961391194 1231 dbSNP
rs912579909 1239 dbSNP
rs991715634 1241 dbSNP
rs987029760 1247 dbSNP
rs954291308 1248 dbSNP
rs1234407199 1260 dbSNP
rs1416891190 1269 dbSNP
rs1028462090 1270 dbSNP
rs1011754900 1286 dbSNP
rs1402095576 1291 dbSNP
rs1341156079 1306 dbSNP
rs957811472 1310 dbSNP
rs538085921 1314 dbSNP
rs369353932 1321 dbSNP
rs1413147232 1325 dbSNP
rs1003272399 1326 dbSNP
rs1341363374 1331 dbSNP
rs184092229 1333 dbSNP
rs1297691529 1334 dbSNP
rs1339258008 1334 dbSNP
rs1220353392 1338 dbSNP
rs970470406 1343 dbSNP
rs569162204 1357 dbSNP
rs868480832 1358 dbSNP
rs1488426493 1361 dbSNP
rs191803695 1365 dbSNP
rs535254640 1366 dbSNP
rs1013425711 1382 dbSNP
rs138638026 1389 dbSNP
rs201284896 1389 dbSNP
rs71749095 1393 dbSNP
rs1432863935 1394 dbSNP
rs1173102350 1395 dbSNP
rs796506322 1404 dbSNP
rs1361352864 1405 dbSNP
rs1402113148 1423 dbSNP
rs1316638056 1424 dbSNP
rs879731619 1424 dbSNP
rs895072867 1426 dbSNP
rs1437803380 1433 dbSNP
rs1478618188 1437 dbSNP
rs1054843760 1439 dbSNP
rs1277053146 1439 dbSNP
rs1192277059 1446 dbSNP
rs114278780 1449 dbSNP
rs1258868979 1450 dbSNP
rs771570749 1452 dbSNP
rs1007470582 1454 dbSNP
rs1446276563 1455 dbSNP
rs1199305371 1474 dbSNP
rs546985751 1476 dbSNP
rs1483095886 1481 dbSNP
rs533250644 1488 dbSNP
rs1381042090 1496 dbSNP
rs1455521497 1506 dbSNP
rs889145758 1507 dbSNP
rs1384532916 1510 dbSNP
rs1220650510 1517 dbSNP
rs1328376147 1520 dbSNP
rs745798362 1528 dbSNP
rs1302039753 1529 dbSNP
rs1277855461 1540 dbSNP
rs778765190 1547 dbSNP
rs574234631 1548 dbSNP
rs770843893 1556 dbSNP
rs1314693750 1564 dbSNP
rs151038440 1571 dbSNP
rs912538947 1572 dbSNP
rs1210161092 1575 dbSNP
rs112247568 1583 dbSNP
rs1467059663 1583 dbSNP
rs909379183 1586 dbSNP
rs986808140 1587 dbSNP
rs954238414 1592 dbSNP
rs958968811 1593 dbSNP
rs189049632 1603 dbSNP
rs928868210 1607 dbSNP
rs1167513894 1610 dbSNP
rs990434882 1611 dbSNP
rs957547527 1628 dbSNP
rs1461370396 1645 dbSNP
rs1032280318 1647 dbSNP
rs1334416103 1655 dbSNP
rs981755584 1658 dbSNP
rs1399260709 1661 dbSNP
rs142834149 1664 dbSNP
rs1304255137 1668 dbSNP
rs1334761833 1676 dbSNP
rs1245115701 1678 dbSNP
rs1471665416 1681 dbSNP
rs1332485480 1683 dbSNP
rs887734667 1686 dbSNP
rs1400558710 1687 dbSNP
rs182999091 1702 dbSNP
rs1481588952 1703 dbSNP
rs1194113235 1709 dbSNP
rs139865174 1715 dbSNP
rs1443197135 1723 dbSNP
rs1009270996 1727 dbSNP
rs1416144113 1728 dbSNP
rs1188793961 1740 dbSNP
rs556900433 1741 dbSNP
rs1460944156 1744 dbSNP
rs1295911624 1746 dbSNP
rs1423775447 1759 dbSNP
rs1314401577 1766 dbSNP
rs1353184221 1766 dbSNP
rs1395205152 1766 dbSNP
rs190403137 1766 dbSNP
rs958147010 1766 dbSNP
rs1007912043 1769 dbSNP
rs1309156092 1769 dbSNP
rs1241875050 1770 dbSNP
rs1200884279 1773 dbSNP
rs559878651 1773 dbSNP
rs889054898 1773 dbSNP
rs1054955468 1775 dbSNP
rs1213123060 1775 dbSNP
rs1458535856 1776 dbSNP
rs540252106 1777 dbSNP
rs1264343307 1783 dbSNP
rs1427233806 1784 dbSNP
rs1170429611 1787 dbSNP
rs73409770 1788 dbSNP
rs557876309 1796 dbSNP
rs185548745 1800 dbSNP
rs1174999239 1807 dbSNP
rs897790202 1807 dbSNP
rs1036487740 1811 dbSNP
rs144707641 1813 dbSNP
rs780032484 1816 dbSNP
rs575463648 1817 dbSNP
rs1244211719 1824 dbSNP
rs373132736 1825 dbSNP
rs1339783655 1826 dbSNP
rs1055987365 1828 dbSNP
rs1448715435 1836 dbSNP
rs561768081 1847 dbSNP
rs940087248 1850 dbSNP
rs1278319836 1851 dbSNP
rs1347385002 1853 dbSNP
rs537214437 1856 dbSNP
rs1262848668 1859 dbSNP
rs1485135004 1860 dbSNP
rs758442426 1865 dbSNP
rs1051220779 1877 dbSNP
rs5756212 1880 dbSNP
rs1392776728 1886 dbSNP
rs1433704424 1889 dbSNP
rs1159471562 1892 dbSNP
rs1407882815 1895 dbSNP
rs1346606856 1897 dbSNP
rs1451290203 1899 dbSNP
rs1288091588 1900 dbSNP
rs114424463 1901 dbSNP
rs1371586215 1901 dbSNP
rs1301308338 1903 dbSNP
rs1370414122 1906 dbSNP
rs1309339097 1907 dbSNP
rs928898880 1907 dbSNP
rs1315365091 1908 dbSNP
rs1457012152 1908 dbSNP
rs1274241614 1909 dbSNP
rs1470204185 1912 dbSNP
rs1212433967 1914 dbSNP
rs1250596942 1915 dbSNP
rs1177292115 1917 dbSNP
rs1409648599 1917 dbSNP
rs1453201798 1917 dbSNP
rs1491419376 1917 dbSNP
rs59128956 1917 dbSNP
rs774505317 1917 dbSNP
rs780255370 1917 dbSNP
rs79444757 1917 dbSNP
rs796673889 1917 dbSNP
rs937241040 1917 dbSNP
rs1491327663 1918 dbSNP
rs774231146 1918 dbSNP
rs1442947485 1920 dbSNP
rs1281371826 1929 dbSNP
rs1371418030 1933 dbSNP
rs1181128900 1935 dbSNP
rs921293579 1954 dbSNP
rs551215478 1961 dbSNP
rs139684028 1967 dbSNP
rs1453516377 1968 dbSNP
rs924773705 1970 dbSNP
rs376760351 1973 dbSNP
rs1204555117 1974 dbSNP
rs1234150640 1979 dbSNP
rs1479439417 1989 dbSNP
rs966392508 1991 dbSNP
rs762376244 1992 dbSNP
rs991902194 1996 dbSNP
rs1209307597 2001 dbSNP
rs754301828 2008 dbSNP
rs1476026027 2013 dbSNP
rs1162542407 2014 dbSNP
rs1354418923 2022 dbSNP
rs1033326411 2042 dbSNP
rs570769838 2043 dbSNP
rs550616394 2044 dbSNP
rs1352898124 2049 dbSNP
rs898415365 2056 dbSNP
rs181063849 2061 dbSNP
rs1413273673 2065 dbSNP
rs1293098759 2067 dbSNP
rs1340634211 2078 dbSNP
rs754282421 2081 dbSNP
rs1332441938 2083 dbSNP
rs55942521 2085 dbSNP
rs890999519 2089 dbSNP
rs985993521 2091 dbSNP
rs1203815016 2095 dbSNP
rs1257707171 2098 dbSNP
rs1363169821 2099 dbSNP
rs374887525 2112 dbSNP
rs536378257 2112 dbSNP
rs1030254128 2116 dbSNP
rs6000286 2116 dbSNP
rs1380273611 2118 dbSNP
rs1157173363 2119 dbSNP
rs1479243694 2132 dbSNP
rs138624064 2141 dbSNP
rs1198431975 2146 dbSNP
rs899809511 2150 dbSNP
rs549097450 2159 dbSNP
rs1413216386 2165 dbSNP
rs1312632779 2174 dbSNP
rs887882269 2176 dbSNP
rs1433503083 2184 dbSNP
rs191063759 2187 dbSNP
rs373384520 2190 dbSNP
rs1226966029 2191 dbSNP
rs1283532649 2192 dbSNP
rs1221844200 2193 dbSNP
rs539838265 2194 dbSNP
rs867443765 2195 dbSNP
rs1045999485 2197 dbSNP
rs1275003979 2198 dbSNP
rs771496509 2217 dbSNP
rs950209884 2224 dbSNP
rs1240232094 2229 dbSNP
rs917441724 2232 dbSNP
rs946290677 2238 dbSNP
rs532899024 2240 dbSNP
rs913595673 2244 dbSNP
rs987841732 2262 dbSNP
rs369194809 2263 dbSNP
rs1033318837 2266 dbSNP
rs1360436809 2269 dbSNP
rs1385954386 2270 dbSNP
rs1402746583 2272 dbSNP
rs1316712026 2273 dbSNP
rs1345075238 2279 dbSNP
rs1316929046 2280 dbSNP
rs974149020 2285 dbSNP
rs962447897 2288 dbSNP
rs1426331357 2303 dbSNP
rs925061673 2304 dbSNP
rs1479597512 2309 dbSNP
rs986242739 2315 dbSNP
rs1015918790 2318 dbSNP
rs544294754 2327 dbSNP
rs1214313141 2329 dbSNP
rs1226992511 2330 dbSNP
rs113899325 2331 dbSNP
rs1356027065 2333 dbSNP
rs976024803 2337 dbSNP
rs1241439843 2347 dbSNP
rs1213561442 2363 dbSNP
rs555583638 2365 dbSNP
rs1364552406 2366 dbSNP
rs1029520374 2386 dbSNP
rs773849224 2395 dbSNP
rs1202845682 2400 dbSNP
rs1320949599 2409 dbSNP
rs1279765476 2411 dbSNP
rs1218708176 2412 dbSNP
rs1328433665 2414 dbSNP
rs1360666193 2415 dbSNP
rs1268877481 2422 dbSNP
rs1015227573 2433 dbSNP
rs141655065 2439 dbSNP
rs1360070889 2447 dbSNP
rs887735470 2455 dbSNP
rs1333886034 2458 dbSNP
rs1034478485 2467 dbSNP
rs1002019360 2470 dbSNP
rs1468614043 2472 dbSNP
rs1054421399 2474 dbSNP
rs907412321 2478 dbSNP
rs1045859344 2480 dbSNP
rs1274913622 2482 dbSNP
rs185764822 2485 dbSNP
rs1171738848 2501 dbSNP
rs1251388547 2505 dbSNP
rs553270065 2508 dbSNP
rs1180011898 2510 dbSNP
rs137872229 2515 dbSNP
rs1417474999 2516 dbSNP
rs1184654192 2520 dbSNP
rs892057841 2522 dbSNP
rs1055082422 2541 dbSNP
rs570799480 2546 dbSNP
rs936350434 2548 dbSNP
rs1392772170 2550 dbSNP
rs924935999 2558 dbSNP
rs950323443 2559 dbSNP
rs917389373 2565 dbSNP
rs1055898465 2566 dbSNP
rs749203921 2570 dbSNP
rs1332550211 2571 dbSNP
rs556954309 2580 dbSNP
rs537135067 2583 dbSNP
rs1251961300 2589 dbSNP
rs1341478433 2593 dbSNP
rs1194164052 2595 dbSNP
rs1251291952 2596 dbSNP
rs368370906 2597 dbSNP
rs1259519337 2599 dbSNP
rs1190472272 2603 dbSNP
rs907787892 2612 dbSNP
rs145363175 2616 dbSNP
rs1306366201 2618 dbSNP
rs528725972 2623 dbSNP
rs1270312995 2631 dbSNP
rs1229577095 2633 dbSNP
rs1166200485 2638 dbSNP
rs952114891 2660 dbSNP
rs180877652 2661 dbSNP
rs552788154 2662 dbSNP
rs1376778588 2672 dbSNP
rs962679065 2679 dbSNP
rs1328149669 2681 dbSNP
rs573642538 2681 dbSNP
rs1226222022 2686 dbSNP
rs1379575355 2702 dbSNP
rs1348840769 2703 dbSNP
rs373177618 2705 dbSNP
rs112130969 2706 dbSNP
rs747206000 2707 dbSNP
rs908225666 2714 dbSNP
rs1187488760 2721 dbSNP
rs1264417716 2737 dbSNP
rs1427294378 2742 dbSNP
rs1166978366 2746 dbSNP
rs982671791 2747 dbSNP
rs190554107 2751 dbSNP
rs555838352 2755 dbSNP
rs564035796 2757 dbSNP
rs1465315742 2758 dbSNP
rs544258085 2766 dbSNP
rs1029466617 2772 dbSNP
rs996682884 2773 dbSNP
rs530597198 2779 dbSNP
rs117144086 2780 dbSNP
rs1000311836 2783 dbSNP
rs1040109116 2786 dbSNP
rs758542175 2788 dbSNP
rs1041734635 2799 dbSNP
rs1216906973 2810 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions TZM-bl
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM1462574. RNA binding protein: AGO2. Condition:TZM-bl ami BaL ...

- Whisnant AW; Bogerd HP; Flores O; Ho P; et al., 2013, mBio.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' gaggucccggcuGGUGGGGUu 5'
                      :||||||| 
Target 5' --ucuaaacuucUCACCCCAc 3'
 		1 - 19
Article - Whisnant AW; Bogerd HP; Flores O; Ho P; et al.
- mBio, 2013
UNLABELLED: The question of how HIV-1 interfaces with cellular microRNA (miRNA) biogenesis and effector mechanisms has been highly controversial. Here, we first used deep sequencing of small RNAs present in two different infected cell lines (TZM-bl and C8166) and two types of primary human cells (CD4(+) peripheral blood mononuclear cells [PBMCs] and macrophages) to unequivocally demonstrate that HIV-1 does not encode any viral miRNAs. Perhaps surprisingly, we also observed that infection of T cells by HIV-1 has only a modest effect on the expression of cellular miRNAs at early times after infection. Comprehensive analysis of miRNA binding to the HIV-1 genome using the photoactivatable ribonucleoside-induced cross-linking and immunoprecipitation (PAR-CLIP) technique revealed several binding sites for cellular miRNAs, a subset of which were shown to be capable of mediating miRNA-mediated repression of gene expression. However, the main finding from this analysis is that HIV-1 transcripts are largely refractory to miRNA binding, most probably due to extensive viral RNA secondary structure. Together, these data demonstrate that HIV-1 neither encodes viral miRNAs nor strongly influences cellular miRNA expression, at least early after infection, and imply that HIV-1 transcripts have evolved to avoid inhibition by preexisting cellular miRNAs by adopting extensive RNA secondary structures that occlude most potential miRNA binding sites. IMPORTANCE: MicroRNAs (miRNAs) are a ubiquitous class of small regulatory RNAs that serve as posttranscriptional regulators of gene expression. Previous work has suggested that HIV-1 might subvert the function of the cellular miRNA machinery by expressing viral miRNAs or by dramatically altering the level of cellular miRNA expression. Using very sensitive approaches, we now demonstrate that neither of these ideas is in fact correct. Moreover, HIV-1 transcripts appear to largely avoid regulation by cellular miRNAs by adopting an extensive RNA secondary structure that occludes the ability of cellular miRNAs to interact with viral mRNAs. Together, these data suggest that HIV-1, rather than seeking to control miRNA function in infected cells, has instead evolved a mechanism to become largely invisible to cellular miRNA effector mechanisms.
LinkOut: [PMID: 23592263]
CLIP-seq Support 1 for dataset GSM1462574
Method / RBP PAR-CLIP / AGO2
Cell line / Condition TZM-bl / TZM-bl ami BaL
Location of target site ENST00000397224.4 | 3UTR | UCUAAACUUCUCACCCCACCACUCUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23592263 / GSE59944
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
67 hsa-miR-6737-5p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT066215 MARCH9 membrane associated ring-CH-type finger 9 2 2
MIRT074413 TNRC6A trinucleotide repeat containing 6A 2 2
MIRT125300 MID1IP1 MID1 interacting protein 1 2 2
MIRT153951 NCOA3 nuclear receptor coactivator 3 2 2
MIRT452776 FAM136A family with sequence similarity 136 member A 2 2
MIRT452977 CABP4 calcium binding protein 4 2 2
MIRT454128 FOXRED2 FAD dependent oxidoreductase domain containing 2 2 2
MIRT455242 DDX39B DExD-box helicase 39B 2 10
MIRT459007 UQCRH ubiquinol-cytochrome c reductase hinge protein 2 2
MIRT459463 MUC17 mucin 17, cell surface associated 2 4
MIRT460871 UBE2S ubiquitin conjugating enzyme E2 S 2 2
MIRT461264 COX10 COX10, heme A:farnesyltransferase cytochrome c oxidase assembly factor 2 2
MIRT464540 UBTF upstream binding transcription factor, RNA polymerase I 2 2
MIRT465268 TRIM28 tripartite motif containing 28 2 2
MIRT465871 TMEM43 transmembrane protein 43 2 4
MIRT466228 TMED10 transmembrane p24 trafficking protein 10 2 2
MIRT468417 SETD1B SET domain containing 1B 2 2
MIRT468684 SEC22C SEC22 homolog C, vesicle trafficking protein 2 4
MIRT473399 MDM4 MDM4, p53 regulator 2 2
MIRT473517 MAX MYC associated factor X 2 2
MIRT474511 KLHDC8A kelch domain containing 8A 2 2
MIRT475801 HDGF heparin binding growth factor 2 2
MIRT479493 CDH6 cadherin 6 2 2
MIRT480770 BMP2 bone morphogenetic protein 2 2 2
MIRT481418 ASB6 ankyrin repeat and SOCS box containing 6 2 2
MIRT482966 CSTF2 cleavage stimulation factor subunit 2 2 2
MIRT483380 SPATA6 spermatogenesis associated 6 2 4
MIRT483677 CYP11A1 cytochrome P450 family 11 subfamily A member 1 2 2
MIRT484328 EPN1 epsin 1 2 4
MIRT484963 UCK1 uridine-cytidine kinase 1 2 2
MIRT485908 PGPEP1 pyroglutamyl-peptidase I 2 4
MIRT488149 PRRC2B proline rich coiled-coil 2B 2 4
MIRT488943 CYP2W1 cytochrome P450 family 2 subfamily W member 1 2 6
MIRT491835 ZBTB7A zinc finger and BTB domain containing 7A 2 4
MIRT493026 NAA50 N(alpha)-acetyltransferase 50, NatE catalytic subunit 2 2
MIRT499374 PLCG2 phospholipase C gamma 2 2 11
MIRT499723 USH1G USH1 protein network component sans 2 4
MIRT500349 ZNF385A zinc finger protein 385A 2 2
MIRT509574 HIST2H2AB histone cluster 2 H2A family member b 2 4
MIRT512794 GLRX glutaredoxin 2 2
MIRT513291 SETBP1 SET binding protein 1 2 2
MIRT515697 ZNF321P zinc finger protein 321, pseudogene 2 2
MIRT518255 LEAP2 liver enriched antimicrobial peptide 2 2 2
MIRT522026 PAQR3 progestin and adipoQ receptor family member 3 2 4
MIRT523169 HIST3H3 histone cluster 3 H3 2 2
MIRT524036 DNAJC8 DnaJ heat shock protein family (Hsp40) member C8 2 2
MIRT533476 TRIM71 tripartite motif containing 71 2 2
MIRT541488 ADM adrenomedullin 2 2
MIRT553987 SRPR SRP receptor alpha subunit 2 2
MIRT571445 YKT6 YKT6 v-SNARE homolog 2 2
MIRT574889 Plcg2 phospholipase C, gamma 2 2 7
MIRT607544 GLI2 GLI family zinc finger 2 2 2
MIRT607688 MAPK10 mitogen-activated protein kinase 10 2 2
MIRT610072 CRLF1 cytokine receptor like factor 1 2 2
MIRT610573 CACUL1 CDK2 associated cullin domain 1 2 2
MIRT614041 THBS2 thrombospondin 2 2 2
MIRT626318 LRTOMT leucine rich transmembrane and O-methyltransferase domain containing 2 2
MIRT634005 RIF1 replication timing regulatory factor 1 2 2
MIRT639619 FGF19 fibroblast growth factor 19 2 2
MIRT647343 RPH3AL rabphilin 3A like (without C2 domains) 2 2
MIRT689704 ATXN2 ataxin 2 2 2
MIRT691170 APOL6 apolipoprotein L6 2 2
MIRT693165 NPR1 natriuretic peptide receptor 1 2 2
MIRT711727 NUPL2 nucleoporin like 2 2 2
MIRT711806 ELN elastin 2 2
MIRT721546 FXN frataxin 2 2
MIRT722979 GDE1 glycerophosphodiester phosphodiesterase 1 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-6737 Ceritinib 57379345 NSC776422 approved sensitive High Non-Small Cell Lung Cancer cell line (H3122, H2228)
hsa-mir-6737 Ceritinib 57379345 NSC776422 approved sensitive cell line (H3122)
hsa-miR-6737-5p Osimertinib 71496458 NSC779217 approved resistant cell line (PC9)
hsa-miR-6737-5p Osimertinib 71496458 NSC779217 approved resistant cell line (HCC827)
hsa-miR-6737-5p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-6737-5p Osimertinib 71496458 NSC779217 approved sensitive cell line (H1975)
hsa-miR-6737-5p Paclitaxel 36314 NSC125973 approved resistant cell line (A2780)
hsa-miR-6737-5p Ceritinib 57379345 NSC776422 approved sensitive cell line (H3122)
hsa-miR-6737-5p Docetaxel+Cisplatin+5-Fluorouracil resistant tissue (hypopharyngeal squamous cell carcinoma)

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