miRTarBase - #MIRT454608


—
pre-miRNA Information
pre-miRNA hsa-mir-6787   
Genomic Coordinates chr17: 82236668 - 82236728
Description Homo sapiens miR-6787 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-6787-5p
Sequence 6| UGGCGGGGGUAGAGCUGGCUGC |27
Evidence Experimental
Experiments Meta-analysis
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs778888046 4 dbSNP
rs772018061 5 dbSNP
rs760886644 6 dbSNP
rs776925052 7 dbSNP
rs760060985 8 dbSNP
rs1432528063 9 dbSNP
rs778772390 10 dbSNP
rs924024166 11 dbSNP
rs201523090 13 dbSNP
rs1451075810 17 dbSNP
rs1378844609 18 dbSNP
Putative Targets

Gene Information
Gene Symbol MYADM   
Synonyms SB135
Description myeloid associated differentiation marker
Transcript NM_001020818   
Other Transcripts NM_001020819 , NM_001020820 , NM_001020821 , NM_138373   
Expression
Putative miRNA Targets on MYADM
3'UTR of MYADM
(miRNA target sites are highlighted)		 
>MYADM|NM_001020818|3'UTR
   1 GACTCTCCCAAGAGGCTCCCGTTCCCTCTCCAACCTCTTTGTTCTTCTTGCCCGAGTTTTCTTTATGGAGTACTTCTTTC
  81 CTCCGCCTTTCCTCTGTTTTCCTCTTCCTGTCTCCCCTCCCTCCCACCTTTTTCTTTCCTTCCCAATTCCTTGCACTCTA
 161 ACCAGTTCTTGGATGCATCTTCTTCCTTCCCTTTCCTCTTGCTGTTTCCTTCCTGTGTTGTTTTGTTGCCCACATCCTGT
 241 TTTCACCCCTGAGCTGTTTCTCTTTTTCTTTTCTTTTTTTTTTTTTTTTTTTTTTAAGACGGATTCTCACTCTGTGGCCC
 321 AGGCTGGAGTGCAGTGGTGCGATCTCGACTCACTGCAACCCCCGCCTCCTGGGTTCAAGCGATTCTCCTGCCCCAGCCTC
 401 CCAAGTAGCTGGGAGGACAGGTGTGAGCTGCCGCACCCAGCCTGTTTCTCTTTTTCCACTCTTCTTTTTTCTCATCTCTT
 481 TTCTGGGTTGCCTGTCGGCTTTCTTATCTGCCTGTTTTGCAAGCACCTTCTCCTGTGTCCTTGGGAGCCCTGAGACTTCT
 561 TTCTCTCCTTGCCTCCACCCACCTCCAAAGGTGCTGAGCTCACATCCACACCCCTTGCAGCCGTCCATGCCACAGCCCCC
 641 CAAGGGGCCCCATTGCCAAAGCATGCCTGCCCACCCTCGCTGTGCCTTAGTCAGTGTGTACGTGTGTGTGTGTGTGTGTG
 721 TGTGTGTGTGTGTTTGGGGGGTGGGGGGTGGGTAGCTGGGGATTGGGCCCTCTTTCTCCCAGTGGAGGAAGGTGTGCAGT
 801 GTACTTCCCCTTTAAATTAAAAAACATATATATATATATATTTGGAGGTCAGTAATTTCCAATGGGCGGGAGGCTTTAAG
 881 CACCGACCCTGGGTCCCTAGGCCCCGCCTGGCACTCAGCCTTGCCAGAGATTGGCTCCAGAATTTTTGCCAGGCTTACAG
 961 AACACCCACTGCCTAGAGGCCATCTTAAAGGAAGCAGGGGCTGGATGCCTTTCATCCCAACTATTCTCTGTGGTATCAAA
1041 AAGAAAAAAAAAAAAAAAGAAGGAGTCGGGGCCGGGCGTGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGACCAAG
1121 TCAGGCAATCATCTGAAGTCAGGAGTTCAAGACCAGCCTGGCCAACATGGTGAAAGCATGTCTCTATTAAAAATACAAAA
1201 ATTAGCCGGGCGTGGTGGCGGGCGCCTGTAATCCCAGGTATTTGGGGGGACTGAGACAGGAGAATCCCTTCAACCCGGGA
1281 GGTGGAGGTTGCAGTAAGTCAAGATGGCACCACTGTGCTCCAGCCTGGGGGACAGAGCGAGACTCCATCTCAAAAAAAAA
1361 AAGGAATCGGACGAAGAACCACAGGATGTTGAAGACAACTGTCTGAAGTATTTGTGAGGGACAGCGATGTGGCCCTCTGT
1441 GTTAAGAATAACGTGTCCTGCTTTGGCAGAGAGAAGAAAATAGCCACTGCCCGCTTTCAAGGCAAGATCGACCTTTTCTG
1521 TTTTGTTTTGTTTTTCTTTCTTTTTCCTGGCCATGAGGACAAAAATTACTGAGTGGCCCTTAAAGAGGGAAGTTTGTTTT
1601 CAGCTGTTCTCTTTTGCCCGTAGGTGGGAGGGTGGGGATTGCTGCGTCCTAGCTAGAGGAATGGCTTTGCTTGAATGTGT
1681 AGTGCACACGCACGGGTGTTTCTGTGTGCTAGTTGCTTCTTGCTGCTGCTTCCTGCTTGTCTGGGACTCACATACATAAC
1761 GTGATATATATATATATATATATAAATGTATAAATATATATTTTATTTTTTTTTAAATCCCTGGAGCTTCTGGTTCCTAT
1841 CAGTTCCTGTTGTTAATCGTAGAACCGTTGTCCCTTCCCCCATTCCCGTATCCATCATGTTCTTTTTCTTTTAAATATCA
1921 ATATAAAGGTAAAAGAAAAAAAAAAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' cgUCGGUCGAGAUGGGGGCGGu 5'
            | :|| : | ||||||||| 
Target 5' cgACTCACTGCAACCCCCGCCt 3'
 346 - 367 160.00 -21.60
2 
miRNA  3' cgucGGUC--GAGAU-GGGGGCGGu 5'
              |::|  | |||  ||||||| 
Target 5' gaccCTGGGTCCCTAGGCCCCGCCt 3'
 885 - 909 148.00 -22.80
3 
miRNA  3' cgUCGGUCGAG-AUGGGGGCGGu 5'
            || :| :|| | ||:||||| 
Target 5' ggAG-TACTTCTTTCCTCCGCCt 3'
 67 - 88 139.00 -20.40
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN31493496 2 COSMIC
COSN31527414 8 COSMIC
COSN30456038 9 COSMIC
COSN30522100 19 COSMIC
COSN26985493 21 COSMIC
COSN30488570 38 COSMIC
COSN31496093 38 COSMIC
COSN31495285 54 COSMIC
COSN31480255 62 COSMIC
COSN30472048 71 COSMIC
COSN30134653 80 COSMIC
COSN18742130 86 COSMIC
COSN17076194 95 COSMIC
COSN30506087 129 COSMIC
COSN15625380 135 COSMIC
COSN6147238 161 COSMIC
COSN31599721 169 COSMIC
COSN26465168 172 COSMIC
COSN31584960 186 COSMIC
COSN20116070 274 COSMIC
COSN19662550 279 COSMIC
COSN15625381 282 COSMIC
COSN7449465 283 COSMIC
COSN31541333 285 COSMIC
COSN30131575 286 COSMIC
COSN30526784 287 COSMIC
COSN20072712 296 COSMIC
COSN6417830 296 COSMIC
COSN28658630 331 COSMIC
COSN31539242 341 COSMIC
COSN8262117 402 COSMIC
COSN30123521 412 COSMIC
COSN26577704 434 COSMIC
COSN30111697 509 COSMIC
COSN27638165 540 COSMIC
COSN31535769 551 COSMIC
COSN30510490 625 COSMIC
COSN15625383 647 COSMIC
COSN31593465 681 COSMIC
COSN23987247 716 COSMIC
COSN31521361 718 COSMIC
COSN15625384 721 COSMIC
COSN20116072 721 COSMIC
COSN31531447 741 COSMIC
COSN26642790 753 COSMIC
COSN15625385 759 COSMIC
COSN15625386 811 COSMIC
COSN29523099 841 COSMIC
COSN31555703 842 COSMIC
COSN22219324 868 COSMIC
COSN31603412 879 COSMIC
COSN30541005 890 COSMIC
COSN30532255 906 COSMIC
COSN30128102 907 COSMIC
COSN32063010 973 COSMIC
COSN28973375 1059 COSMIC
COSN28058869 1064 COSMIC
COSN30127136 1078 COSMIC
COSN30122738 1087 COSMIC
COSN31536402 1092 COSMIC
COSN30118441 1220 COSMIC
COSN15625387 1234 COSMIC
COSN30512539 1277 COSMIC
COSN31588524 1369 COSMIC
COSN26551860 1370 COSMIC
COSN28794141 1386 COSMIC
COSN6147239 1430 COSMIC
COSN30176715 1479 COSMIC
COSN31594112 1493 COSMIC
COSN22772265 1499 COSMIC
COSN31539238 1510 COSMIC
COSN30111621 1511 COSMIC
COSN31550718 1519 COSMIC
COSN15625388 1562 COSMIC
COSN30139657 1620 COSMIC
COSN31521860 1624 COSMIC
COSN31550722 1678 COSMIC
COSN26700165 1683 COSMIC
COSN24306785 1708 COSMIC
COSN31490752 1750 COSMIC
COSN32061324 1784 COSMIC
COSN30116876 1805 COSMIC
COSN31535779 1806 COSMIC
COSN31545468 1806 COSMIC
COSN31521158 1812 COSMIC
COSN30118532 1815 COSMIC
COSN30513365 1816 COSMIC
COSN2502701 1840 COSMIC
COSN30111895 1867 COSMIC
COSN31537413 1885 COSMIC
COSN22788733 1888 COSMIC
COSN31602968 1888 COSMIC
COSN31589424 1893 COSMIC
COSN15625389 1903 COSMIC
COSN15625390 1920 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1261751321 3 dbSNP
rs758023754 9 dbSNP
rs539239850 15 dbSNP
rs952383653 16 dbSNP
rs1427838911 17 dbSNP
rs150038158 20 dbSNP
rs1173391513 21 dbSNP
rs367717726 22 dbSNP
rs575741725 34 dbSNP
rs1226264277 35 dbSNP
rs1399074296 35 dbSNP
rs769674064 36 dbSNP
rs775615235 38 dbSNP
rs1289528944 42 dbSNP
rs779291028 42 dbSNP
rs1428700853 45 dbSNP
rs763160821 46 dbSNP
rs8108855 48 dbSNP
rs370203126 52 dbSNP
rs1430248272 55 dbSNP
rs972690758 57 dbSNP
rs1275613440 64 dbSNP
rs554747170 66 dbSNP
rs1193470241 67 dbSNP
rs933467980 71 dbSNP
rs570066723 76 dbSNP
rs573221688 77 dbSNP
rs1213427104 82 dbSNP
rs1430567702 85 dbSNP
rs986202718 86 dbSNP
rs540198083 95 dbSNP
rs551387109 103 dbSNP
rs947411424 120 dbSNP
rs1309816801 124 dbSNP
rs779848283 128 dbSNP
rs1372529680 129 dbSNP
rs1353768006 132 dbSNP
rs1460543297 134 dbSNP
rs903144986 140 dbSNP
rs1295425010 144 dbSNP
rs934606482 147 dbSNP
rs1369652265 149 dbSNP
rs576679117 150 dbSNP
rs895672617 155 dbSNP
rs1463422812 161 dbSNP
rs1355059702 162 dbSNP
rs774109786 164 dbSNP
rs1421585074 169 dbSNP
rs1419564666 171 dbSNP
rs1188286766 176 dbSNP
rs1395214507 178 dbSNP
rs1460721091 187 dbSNP
rs569585772 190 dbSNP
rs1022754153 191 dbSNP
rs1481894000 192 dbSNP
rs948696421 193 dbSNP
rs979455030 196 dbSNP
rs1275139101 197 dbSNP
rs888200062 199 dbSNP
rs926209783 209 dbSNP
rs1234055937 221 dbSNP
rs544010038 226 dbSNP
rs1350130635 232 dbSNP
rs553537092 236 dbSNP
rs1363601610 242 dbSNP
rs934851178 244 dbSNP
rs1292935891 246 dbSNP
rs1294430686 253 dbSNP
rs111975490 259 dbSNP
rs1246353012 261 dbSNP
rs1456336265 261 dbSNP
rs370129533 262 dbSNP
rs200232779 263 dbSNP
rs1295651384 264 dbSNP
rs1421324234 265 dbSNP
rs1336183763 268 dbSNP
rs879074315 269 dbSNP
rs1490265636 270 dbSNP
rs376789576 273 dbSNP
rs1300345404 274 dbSNP
rs1325971559 274 dbSNP
rs1373130203 274 dbSNP
rs1438578256 274 dbSNP
rs1467529430 274 dbSNP
rs1491183467 274 dbSNP
rs201228132 274 dbSNP
rs67727940 274 dbSNP
rs1491473042 275 dbSNP
rs1213432217 276 dbSNP
rs879047972 277 dbSNP
rs307934 278 dbSNP
rs200046918 279 dbSNP
rs867970478 280 dbSNP
rs1053269277 281 dbSNP
rs1426808791 282 dbSNP
rs1143256 283 dbSNP
rs529846043 284 dbSNP
rs1474864710 285 dbSNP
rs1486335185 287 dbSNP
rs1255148522 288 dbSNP
rs1159701767 296 dbSNP
rs1349927017 296 dbSNP
rs1162746838 299 dbSNP
rs1304163436 300 dbSNP
rs1346690863 301 dbSNP
rs1454130337 304 dbSNP
rs1319724416 305 dbSNP
rs1382395866 310 dbSNP
rs143563170 330 dbSNP
rs1143262 331 dbSNP
rs1174881599 332 dbSNP
rs527304889 332 dbSNP
rs1416076345 339 dbSNP
rs1371338443 342 dbSNP
rs1195449185 347 dbSNP
rs34351034 347 dbSNP
rs879464517 347 dbSNP
rs437403 348 dbSNP
rs379364 349 dbSNP
rs1204273508 351 dbSNP
rs1040691115 360 dbSNP
rs1271378331 364 dbSNP
rs1233166586 365 dbSNP
rs1311227501 372 dbSNP
rs1319036179 373 dbSNP
rs1005673777 381 dbSNP
rs1377590599 382 dbSNP
rs996518051 384 dbSNP
rs1409849673 385 dbSNP
rs1240294469 388 dbSNP
rs532899262 393 dbSNP
rs1169693742 394 dbSNP
rs1462621071 400 dbSNP
rs146800015 405 dbSNP
rs1186011972 406 dbSNP
rs1004466729 408 dbSNP
rs569465512 412 dbSNP
rs1015401425 433 dbSNP
rs961306112 437 dbSNP
rs1275072336 438 dbSNP
rs972308127 441 dbSNP
rs1355107539 443 dbSNP
rs1014385266 449 dbSNP
rs1185632546 451 dbSNP
rs1023046690 455 dbSNP
rs1410070356 459 dbSNP
rs1334504711 460 dbSNP
rs1441988962 460 dbSNP
rs1331530668 462 dbSNP
rs1411031852 464 dbSNP
rs1393749603 466 dbSNP
rs114749560 467 dbSNP
rs1158179335 472 dbSNP
rs1361683481 474 dbSNP
rs1436241546 475 dbSNP
rs1313143047 477 dbSNP
rs954904907 479 dbSNP
rs978764558 479 dbSNP
rs926218627 480 dbSNP
rs1468467002 488 dbSNP
rs1234518487 490 dbSNP
rs13869 491 dbSNP
rs12035 497 dbSNP
rs947498728 501 dbSNP
rs1301603381 504 dbSNP
rs533933651 508 dbSNP
rs140609603 511 dbSNP
rs1267175947 515 dbSNP
rs775830316 523 dbSNP
rs1223564919 527 dbSNP
rs944874971 531 dbSNP
rs1306791138 532 dbSNP
rs765499356 541 dbSNP
rs1352005787 545 dbSNP
rs1040806903 555 dbSNP
rs1323942849 567 dbSNP
rs921000121 567 dbSNP
rs1395483167 573 dbSNP
rs924652390 582 dbSNP
rs79815365 586 dbSNP
rs1057097393 588 dbSNP
rs1409805509 592 dbSNP
rs895726230 596 dbSNP
rs1158961543 599 dbSNP
rs948573403 601 dbSNP
rs1044252827 612 dbSNP
rs888241735 613 dbSNP
rs1393239855 621 dbSNP
rs888367447 623 dbSNP
rs1241032949 624 dbSNP
rs1213135364 628 dbSNP
rs1004092363 641 dbSNP
rs1286725840 642 dbSNP
rs1241393995 648 dbSNP
rs1347749386 649 dbSNP
rs1301967498 651 dbSNP
rs1036946035 654 dbSNP
rs1234515961 666 dbSNP
rs1288367046 679 dbSNP
rs1428840826 687 dbSNP
rs895683952 689 dbSNP
rs868602179 694 dbSNP
rs1480947242 700 dbSNP
rs1014080856 701 dbSNP
rs1212933356 702 dbSNP
rs1213560535 702 dbSNP
rs1278647194 702 dbSNP
rs1294885942 702 dbSNP
rs1313326793 702 dbSNP
rs1353259610 702 dbSNP
rs1414412902 702 dbSNP
rs1473067124 702 dbSNP
rs3835132 702 dbSNP
rs61277796 702 dbSNP
rs67312116 702 dbSNP
rs757743778 702 dbSNP
rs879099764 702 dbSNP
rs879228100 702 dbSNP
rs879238795 702 dbSNP
rs1248101157 703 dbSNP
rs1435209071 703 dbSNP
rs1455437843 704 dbSNP
rs1173803887 708 dbSNP
rs1394172523 712 dbSNP
rs1432314007 714 dbSNP
rs9797893 715 dbSNP
rs9797904 716 dbSNP
rs7409372 717 dbSNP
rs7409422 718 dbSNP
rs200926004 721 dbSNP
rs1329054368 724 dbSNP
rs1186704467 725 dbSNP
rs1474022153 735 dbSNP
rs1255798680 736 dbSNP
rs1462913182 736 dbSNP
rs1483851970 737 dbSNP
rs1298129816 738 dbSNP
rs1375066098 739 dbSNP
rs1443567489 740 dbSNP
rs1304428187 741 dbSNP
rs1370600502 743 dbSNP
rs970146698 744 dbSNP
rs1258800961 746 dbSNP
rs1232861430 749 dbSNP
rs1217526849 750 dbSNP
rs1275253559 753 dbSNP
rs1396435004 754 dbSNP
rs1372516958 756 dbSNP
rs1032981881 758 dbSNP
rs1444305426 766 dbSNP
rs1005313122 769 dbSNP
rs150726206 770 dbSNP
rs868327788 770 dbSNP
rs1163619265 775 dbSNP
rs1037165906 777 dbSNP
rs1419639573 780 dbSNP
rs896843650 782 dbSNP
rs544146167 793 dbSNP
rs1030576234 800 dbSNP
rs954958930 802 dbSNP
rs1213202477 826 dbSNP
rs1275363534 826 dbSNP
rs1481925697 826 dbSNP
rs779596320 826 dbSNP
rs1245223864 827 dbSNP
rs1007728513 829 dbSNP
rs1304601401 830 dbSNP
rs1017782061 831 dbSNP
rs1377582000 833 dbSNP
rs556162243 835 dbSNP
rs969266306 837 dbSNP
rs1187935261 841 dbSNP
rs1396206118 843 dbSNP
rs1419550359 850 dbSNP
rs1408880000 858 dbSNP
rs1452613887 859 dbSNP
rs1363544309 863 dbSNP
rs377597340 868 dbSNP
rs307935 876 dbSNP
rs541632637 881 dbSNP
rs758648082 882 dbSNP
rs1463328155 883 dbSNP
rs1036977163 885 dbSNP
rs1393980792 886 dbSNP
rs895715078 888 dbSNP
rs992825772 889 dbSNP
rs949880783 901 dbSNP
rs992416482 901 dbSNP
rs560198351 903 dbSNP
rs1302665097 904 dbSNP
rs527342689 906 dbSNP
rs1044306811 907 dbSNP
rs909735875 912 dbSNP
rs941174336 914 dbSNP
rs1276214980 921 dbSNP
rs545907342 925 dbSNP
rs564119497 930 dbSNP
rs896890705 931 dbSNP
rs1272273573 933 dbSNP
rs1033509273 934 dbSNP
rs1421982556 936 dbSNP
rs1449680877 937 dbSNP
rs531314513 942 dbSNP
rs1361722292 951 dbSNP
rs1173495462 955 dbSNP
rs1217423569 966 dbSNP
rs1453118238 972 dbSNP
rs997848153 976 dbSNP
rs1199699202 980 dbSNP
rs1428117125 997 dbSNP
rs891830478 1001 dbSNP
rs551332902 1006 dbSNP
rs1010180179 1020 dbSNP
rs1488461632 1021 dbSNP
rs1190942838 1025 dbSNP
rs1279348951 1029 dbSNP
rs1422077265 1030 dbSNP
rs1476496100 1035 dbSNP
rs1208593578 1036 dbSNP
rs1166325706 1037 dbSNP
rs307936 1038 dbSNP
rs1226113341 1040 dbSNP
rs1324321388 1041 dbSNP
rs966237949 1043 dbSNP
rs112445871 1044 dbSNP
rs1358384523 1044 dbSNP
rs1405042126 1044 dbSNP
rs756954605 1044 dbSNP
rs1403966118 1045 dbSNP
rs1173202346 1052 dbSNP
rs974889454 1053 dbSNP
rs1371542831 1055 dbSNP
rs1029122310 1056 dbSNP
rs1478289920 1056 dbSNP
rs201704574 1057 dbSNP
rs952308927 1057 dbSNP
rs11428235 1058 dbSNP
rs1486594961 1058 dbSNP
rs76834341 1058 dbSNP
rs983919497 1059 dbSNP
rs75050160 1060 dbSNP
rs1252553546 1061 dbSNP
rs1357486187 1067 dbSNP
rs1233775961 1068 dbSNP
rs1292615866 1069 dbSNP
rs1050722880 1074 dbSNP
rs151065909 1075 dbSNP
rs183125924 1078 dbSNP
rs889417872 1079 dbSNP
rs963855937 1080 dbSNP
rs1007780830 1090 dbSNP
rs534066491 1091 dbSNP
rs972366336 1095 dbSNP
rs1485725578 1100 dbSNP
rs1018253425 1110 dbSNP
rs1466320652 1121 dbSNP
rs968941217 1123 dbSNP
rs1189194226 1129 dbSNP
rs1368402825 1134 dbSNP
rs1162527823 1143 dbSNP
rs1472007555 1149 dbSNP
rs187474838 1157 dbSNP
rs1408947241 1158 dbSNP
rs570539220 1172 dbSNP
rs1031792547 1177 dbSNP
rs1198777392 1178 dbSNP
rs1467726633 1179 dbSNP
rs752052149 1193 dbSNP
rs537814494 1197 dbSNP
rs1231827479 1203 dbSNP
rs1377298456 1207 dbSNP
rs992878187 1208 dbSNP
rs1238899120 1209 dbSNP
rs780742747 1211 dbSNP
rs764742618 1212 dbSNP
rs1312198709 1213 dbSNP
rs1324070661 1216 dbSNP
rs556443690 1217 dbSNP
rs1444075586 1218 dbSNP
rs574598730 1220 dbSNP
rs935826762 1221 dbSNP
rs535649499 1224 dbSNP
rs1054576097 1225 dbSNP
rs909777682 1228 dbSNP
rs1250612528 1235 dbSNP
rs891857547 1237 dbSNP
rs190705050 1243 dbSNP
rs1291010364 1244 dbSNP
rs537813494 1246 dbSNP
rs941238540 1250 dbSNP
rs1481941078 1251 dbSNP
rs1018867384 1256 dbSNP
rs572268449 1257 dbSNP
rs1301375360 1261 dbSNP
rs1441233477 1268 dbSNP
rs1184640235 1275 dbSNP
rs1350732364 1276 dbSNP
rs1037272224 1277 dbSNP
rs1233766684 1278 dbSNP
rs1439490062 1283 dbSNP
rs1176933241 1287 dbSNP
rs369935178 1295 dbSNP
rs11555355 1297 dbSNP
rs1362364141 1301 dbSNP
rs16985237 1310 dbSNP
rs996423256 1311 dbSNP
rs1392670116 1313 dbSNP
rs17406642 1331 dbSNP
rs1399936973 1334 dbSNP
rs952273474 1336 dbSNP
rs1192909544 1339 dbSNP
rs566590150 1352 dbSNP
rs753491354 1352 dbSNP
rs75956082 1352 dbSNP
rs985343744 1352 dbSNP
rs75209913 1353 dbSNP
rs1329481246 1354 dbSNP
rs1221052821 1358 dbSNP
rs1334890996 1359 dbSNP
rs199966830 1361 dbSNP
rs762258421 1361 dbSNP
rs1428904197 1363 dbSNP
rs80007675 1364 dbSNP
rs918389961 1369 dbSNP
rs916882977 1370 dbSNP
rs1373601627 1373 dbSNP
rs933751962 1384 dbSNP
rs370296515 1391 dbSNP
rs1165731083 1408 dbSNP
rs1232890017 1426 dbSNP
rs1253702327 1430 dbSNP
rs980077879 1436 dbSNP
rs927190452 1438 dbSNP
rs935873093 1442 dbSNP
rs1236307532 1449 dbSNP
rs1212322210 1453 dbSNP
rs73935998 1455 dbSNP
rs913326896 1456 dbSNP
rs946095659 1458 dbSNP
rs889471950 1468 dbSNP
rs1274332790 1470 dbSNP
rs1278571686 1474 dbSNP
rs1414008790 1481 dbSNP
rs747640867 1482 dbSNP
rs1353467976 1486 dbSNP
rs1304456141 1492 dbSNP
rs1448672287 1493 dbSNP
rs1353369929 1494 dbSNP
rs1167727703 1503 dbSNP
rs1039319119 1510 dbSNP
rs573216996 1511 dbSNP
rs901885756 1514 dbSNP
rs996118770 1519 dbSNP
rs376993265 1521 dbSNP
rs1184039106 1523 dbSNP
rs844114 1525 dbSNP
rs3207655 1526 dbSNP
rs183285501 1527 dbSNP
rs139020198 1531 dbSNP
rs202172372 1533 dbSNP
rs372413839 1533 dbSNP
rs1259010990 1534 dbSNP
rs543024957 1539 dbSNP
rs1375950556 1554 dbSNP
rs1476440023 1555 dbSNP
rs1314644596 1558 dbSNP
rs891939833 1560 dbSNP
rs961121521 1563 dbSNP
rs1372590020 1571 dbSNP
rs993958470 1575 dbSNP
rs1448440370 1578 dbSNP
rs563202113 1579 dbSNP
rs530291330 1580 dbSNP
rs1014365522 1593 dbSNP
rs1400561365 1600 dbSNP
rs1024377816 1602 dbSNP
rs1324735759 1605 dbSNP
rs769445240 1610 dbSNP
rs1399543580 1612 dbSNP
rs1348461297 1616 dbSNP
rs1167379285 1619 dbSNP
rs1024055306 1620 dbSNP
rs548855014 1621 dbSNP
rs1176841075 1624 dbSNP
rs980502706 1630 dbSNP
rs1238867709 1631 dbSNP
rs1016892151 1634 dbSNP
rs1487639003 1638 dbSNP
rs1327718558 1646 dbSNP
rs962952213 1647 dbSNP
rs1242246032 1664 dbSNP
rs972644651 1667 dbSNP
rs918433814 1673 dbSNP
rs1384668100 1679 dbSNP
rs933803989 1680 dbSNP
rs1392494125 1683 dbSNP
rs986541081 1685 dbSNP
rs1295647907 1686 dbSNP
rs910962357 1689 dbSNP
rs74684595 1690 dbSNP
rs1360300859 1691 dbSNP
rs990000984 1694 dbSNP
rs140264258 1695 dbSNP
rs1380940748 1696 dbSNP
rs913106097 1703 dbSNP
rs1431628988 1705 dbSNP
rs1269826077 1708 dbSNP
rs1191545816 1712 dbSNP
rs903484377 1716 dbSNP
rs1197104339 1717 dbSNP
rs1354354978 1719 dbSNP
rs936264304 1720 dbSNP
rs1332449827 1722 dbSNP
rs1053348982 1723 dbSNP
rs1275391577 1733 dbSNP
rs1469204611 1740 dbSNP
rs1301462879 1742 dbSNP
rs187909934 1743 dbSNP
rs1209403830 1746 dbSNP
rs1040463486 1750 dbSNP
rs1340246829 1757 dbSNP
rs864858 1759 dbSNP
rs1402370626 1761 dbSNP
rs891992141 1761 dbSNP
rs1346421485 1764 dbSNP
rs1361777112 1764 dbSNP
rs1415567396 1764 dbSNP
rs35288828 1764 dbSNP
rs397842766 1764 dbSNP
rs4023843 1764 dbSNP
rs533829056 1764 dbSNP
rs773061958 1764 dbSNP
rs1448807048 1768 dbSNP
rs1014419247 1772 dbSNP
rs1276660402 1777 dbSNP
rs1422794370 1781 dbSNP
rs11555354 1782 dbSNP
rs60886818 1783 dbSNP
rs1024430077 1784 dbSNP
rs1341671179 1786 dbSNP
rs1167044857 1787 dbSNP
rs1334022399 1789 dbSNP
rs749133479 1794 dbSNP
rs888041075 1796 dbSNP
rs570584350 1797 dbSNP
rs905944998 1798 dbSNP
rs1001588192 1806 dbSNP
rs1303523916 1806 dbSNP
rs201983992 1806 dbSNP
rs1421811061 1808 dbSNP
rs537852293 1815 dbSNP
rs111486635 1818 dbSNP
rs8604 1822 dbSNP
rs1025500608 1823 dbSNP
rs115895569 1834 dbSNP
rs1024085120 1840 dbSNP
rs1297083897 1843 dbSNP
rs1337809562 1848 dbSNP
rs971112913 1853 dbSNP
rs759459683 1860 dbSNP
rs1052956 1863 dbSNP
rs1218881226 1867 dbSNP
rs554010618 1868 dbSNP
rs1284009503 1875 dbSNP
rs746179108 1876 dbSNP
rs1244603291 1878 dbSNP
rs990505625 1879 dbSNP
rs1263888714 1883 dbSNP
rs942452065 1888 dbSNP
rs979175065 1889 dbSNP
rs753666536 1893 dbSNP
rs1389685276 1895 dbSNP
rs572301295 1898 dbSNP
rs1473716721 1902 dbSNP
rs924958990 1903 dbSNP
rs1353161299 1906 dbSNP
rs1065323 1909 dbSNP
rs61577158 1913 dbSNP
rs1437220451 1918 dbSNP
rs1205978389 1919 dbSNP
rs967205474 1925 dbSNP
rs934994338 1927 dbSNP
rs1053395158 1928 dbSNP
rs1467772588 1929 dbSNP
rs1189900061 1933 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions TZM-bl
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM1462574. RNA binding protein: AGO2. Condition:TZM-bl ami BaL ...

- Whisnant AW; Bogerd HP; Flores O; Ho P; et al., 2013, mBio.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' cgUCGGUCGAGAUGGGGGCGGu 5'
            | :|| : | ||||||||| 
Target 5' --ACUCACUGCAACCCCCGCCu 3'
 		1 - 20
Article - Whisnant AW; Bogerd HP; Flores O; Ho P; et al.
- mBio, 2013
UNLABELLED: The question of how HIV-1 interfaces with cellular microRNA (miRNA) biogenesis and effector mechanisms has been highly controversial. Here, we first used deep sequencing of small RNAs present in two different infected cell lines (TZM-bl and C8166) and two types of primary human cells (CD4(+) peripheral blood mononuclear cells [PBMCs] and macrophages) to unequivocally demonstrate that HIV-1 does not encode any viral miRNAs. Perhaps surprisingly, we also observed that infection of T cells by HIV-1 has only a modest effect on the expression of cellular miRNAs at early times after infection. Comprehensive analysis of miRNA binding to the HIV-1 genome using the photoactivatable ribonucleoside-induced cross-linking and immunoprecipitation (PAR-CLIP) technique revealed several binding sites for cellular miRNAs, a subset of which were shown to be capable of mediating miRNA-mediated repression of gene expression. However, the main finding from this analysis is that HIV-1 transcripts are largely refractory to miRNA binding, most probably due to extensive viral RNA secondary structure. Together, these data demonstrate that HIV-1 neither encodes viral miRNAs nor strongly influences cellular miRNA expression, at least early after infection, and imply that HIV-1 transcripts have evolved to avoid inhibition by preexisting cellular miRNAs by adopting extensive RNA secondary structures that occlude most potential miRNA binding sites. IMPORTANCE: MicroRNAs (miRNAs) are a ubiquitous class of small regulatory RNAs that serve as posttranscriptional regulators of gene expression. Previous work has suggested that HIV-1 might subvert the function of the cellular miRNA machinery by expressing viral miRNAs or by dramatically altering the level of cellular miRNA expression. Using very sensitive approaches, we now demonstrate that neither of these ideas is in fact correct. Moreover, HIV-1 transcripts appear to largely avoid regulation by cellular miRNAs by adopting an extensive RNA secondary structure that occludes the ability of cellular miRNAs to interact with viral mRNAs. Together, these data suggest that HIV-1, rather than seeking to control miRNA function in infected cells, has instead evolved a mechanism to become largely invisible to cellular miRNA effector mechanisms.
LinkOut: [PMID: 23592263]
CLIP-seq Support 1 for dataset GSM1462574
Method / RBP PAR-CLIP / AGO2
Cell line / Condition TZM-bl / TZM-bl ami BaL
Location of target site ENST00000391770.4 | 3UTR | ACUCACUGCAACCCCCGCCUCCUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23592263 / GSE59944
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
90 hsa-miR-6787-5p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT449091 XPO6 exportin 6 2 2
MIRT449991 PSMG1 proteasome assembly chaperone 1 2 2
MIRT454608 MYADM myeloid associated differentiation marker 2 2
MIRT456116 VAV3 vav guanine nucleotide exchange factor 3 2 6
MIRT457064 TOR4A torsin family 4 member A 2 2
MIRT461023 SDF4 stromal cell derived factor 4 2 2
MIRT467197 SPRY4 sprouty RTK signaling antagonist 4 2 2
MIRT471711 OTUB1 OTU deubiquitinase, ubiquitin aldehyde binding 1 2 2
MIRT472566 NACC1 nucleus accumbens associated 1 2 2
MIRT476079 GRB2 growth factor receptor bound protein 2 2 2
MIRT480150 CALR calreticulin 2 2
MIRT483027 KHSRP KH-type splicing regulatory protein 2 4
MIRT483498 STMN3 stathmin 3 2 4
MIRT483728 THSD4 thrombospondin type 1 domain containing 4 2 2
MIRT484550 BARHL1 BarH like homeobox 1 2 6
MIRT484684 PACSIN1 protein kinase C and casein kinase substrate in neurons 1 2 2
MIRT486059 CTDNEP1 CTD nuclear envelope phosphatase 1 2 2
MIRT486116 INO80E INO80 complex subunit E 2 2
MIRT486313 SIPA1 signal-induced proliferation-associated 1 2 2
MIRT486525 CLCN7 chloride voltage-gated channel 7 2 2
MIRT486857 DPF1 double PHD fingers 1 2 2
MIRT487352 PHF15 jade family PHD finger 2 1 1
MIRT487582 FAM83H family with sequence similarity 83 member H 2 4
MIRT487792 GPR20 G protein-coupled receptor 20 2 4
MIRT488104 POU3F1 POU class 3 homeobox 1 2 2
MIRT488786 POFUT2 protein O-fucosyltransferase 2 2 2
MIRT489361 SYNGR1 synaptogyrin 1 2 4
MIRT489387 RAB11B RAB11B, member RAS oncogene family 2 2
MIRT489680 SCAMP4 secretory carrier membrane protein 4 2 2
MIRT489731 GNAI2 G protein subunit alpha i2 2 4
MIRT489750 TACC3 transforming acidic coiled-coil containing protein 3 2 2
MIRT490029 PCSK4 proprotein convertase subtilisin/kexin type 4 2 2
MIRT490379 LHFPL3 LHFPL tetraspan subfamily member 3 2 2
MIRT490580 SLC47A1 solute carrier family 47 member 1 2 2
MIRT490753 SRCIN1 SRC kinase signaling inhibitor 1 2 2
MIRT491187 JUND JunD proto-oncogene, AP-1 transcription factor subunit 2 4
MIRT491301 VGF VGF nerve growth factor inducible 2 2
MIRT491462 HOXB8 homeobox B8 2 2
MIRT491702 PDZD4 PDZ domain containing 4 2 2
MIRT491724 RTN4R reticulon 4 receptor 2 2
MIRT491737 SEMA3F semaphorin 3F 2 2
MIRT491984 UNK unkempt family zinc finger 2 2
MIRT492844 NRGN neurogranin 2 2
MIRT492936 NEUROD2 neuronal differentiation 2 2 4
MIRT493713 H2AFX H2A histone family member X 2 2
MIRT494623 ASB6 ankyrin repeat and SOCS box containing 6 2 4
MIRT494703 ARHGAP31 Rho GTPase activating protein 31 2 2
MIRT495602 NKX2-5 NK2 homeobox 5 2 2
MIRT495750 PDE4C phosphodiesterase 4C 2 4
MIRT500367 ZNF385A zinc finger protein 385A 2 2
MIRT501161 SLC10A7 solute carrier family 10 member 7 2 6
MIRT501702 PCGF3 polycomb group ring finger 3 2 6
MIRT504922 PDRG1 p53 and DNA damage regulated 1 2 2
MIRT517945 TRIM59 tripartite motif containing 59 2 2
MIRT524212 DDI2 DNA damage inducible 1 homolog 2 2 6
MIRT531186 SIGLEC12 sialic acid binding Ig like lectin 12 (gene/pseudogene) 2 2
MIRT531972 C12orf49 chromosome 12 open reading frame 49 2 2
MIRT558055 EVI5L ecotropic viral integration site 5 like 2 2
MIRT560482 LACE1 AFG1 like ATPase 2 2
MIRT563217 FXN frataxin 2 2
MIRT569095 FSCN1 fascin actin-bundling protein 1 2 2
MIRT569522 AP5Z1 adaptor related protein complex 5 zeta 1 subunit 2 2
MIRT569531 CTTN cortactin 2 2
MIRT569848 RGS5 regulator of G protein signaling 5 2 2
MIRT570738 ANKRD52 ankyrin repeat domain 52 2 2
MIRT574140 MARVELD1 MARVEL domain containing 1 2 2
MIRT615994 DHTKD1 dehydrogenase E1 and transketolase domain containing 1 2 2
MIRT628493 ZNF556 zinc finger protein 556 2 2
MIRT633451 KLLN killin, p53-regulated DNA replication inhibitor 2 2
MIRT649054 SLC1A2 solute carrier family 1 member 2 2 2
MIRT649340 HEXA hexosaminidase subunit alpha 2 2
MIRT670226 PTCHD1 patched domain containing 1 2 2
MIRT670666 KIAA1551 KIAA1551 2 2
MIRT671452 CDH7 cadherin 7 2 2
MIRT671729 ZNF451 zinc finger protein 451 2 2
MIRT690285 ZNF154 zinc finger protein 154 2 2
MIRT700575 PRSS22 protease, serine 22 2 2
MIRT701411 NKRF NFKB repressing factor 2 2
MIRT711877 VASP vasodilator stimulated phosphoprotein 2 2
MIRT712082 UNC13A unc-13 homolog A 2 2
MIRT712523 CYTH2 cytohesin 2 2 2
MIRT712751 GMDS GDP-mannose 4,6-dehydratase 2 2
MIRT714681 PRX periaxin 2 2
MIRT714718 VPS8 VPS8, CORVET complex subunit 2 2
MIRT717508 HRNR hornerin 2 2
MIRT717650 THBS2 thrombospondin 2 2 2
MIRT719592 PIAS4 protein inhibitor of activated STAT 4 2 2
MIRT720521 PTGR2 prostaglandin reductase 2 2 2
MIRT721295 C3orf36 chromosome 3 open reading frame 36 2 2
MIRT724922 VPS18 VPS18, CORVET/HOPS core subunit 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-6787 Ceritinib 57379345 NSC776422 approved sensitive High Non-Small Cell Lung Cancer cell line (H3122, H2228)
hsa-miR-6787-5p Dabrafenib 44462760 NSC764134 approved resistant High Melanoma cell line (A375, IGR37, 501Mel)
hsa-miR-6787-5p Vemurafenib 42611257 NSC761431 approved resistant High Melanoma cell line (A375, IGR37, 501Mel)
hsa-miR-6787-5p Cisplatin 5460033 NSC119875 approved sensitive cell line
hsa-miR-6787-5p Gefitinib 123631 NSC715055 approved resistant cell line (HCC827)
hsa-miR-6787-5p Tamoxifen 2733525 NSC180973 approved sensitive cell line (LCC2)
hsa-miR-6787-5p Osimertinib 71496458 NSC779217 approved sensitive cell line (H1975)
hsa-miR-6787-5p Paclitaxel 36314 NSC125973 approved resistant cell line (A2780)
hsa-miR-6787-5p Cisplatin 5460033 NSC119875 approved resistant cell line (A2780)
hsa-miR-6787-5p Docetaxel+Cisplatin+5-Fluorouracil resistant tissue (hypopharyngeal squamous cell carcinoma)

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