miRTarBase - #MIRT454810


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pre-miRNA Information
pre-miRNA hsa-mir-6871   
Genomic Coordinates chr20: 41169023 - 41169078
Description Homo sapiens miR-6871 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-6871-3p
Sequence 35| CAGCACCCUGUGGCUCCCACAG |56
Evidence Experimental
Experiments Meta-analysis
DRVs in miRNA
Mutant ID Mutant Position Mutant Source
COSN16670239 4 COSMIC
COSN1872096 9 COSMIC
COSM1741616 16 COSMIC
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs545076040 1 dbSNP
rs1273348199 2 dbSNP
rs1202373059 5 dbSNP
rs1340707970 7 dbSNP
rs372994756 8 dbSNP
rs869070782 15 dbSNP
rs931272568 16 dbSNP
rs1333765165 18 dbSNP
Putative Targets

Gene Information
Gene Symbol NEDD9   
Synonyms CAS-L, CAS2, CASL, CASS2, HEF1
Description neural precursor cell expressed, developmentally down-regulated 9
Transcript NM_001142393   
Other Transcripts NM_006403 , NM_182966   
Expression
Putative miRNA Targets on NEDD9
3'UTR of NEDD9
(miRNA target sites are highlighted)		 
>NEDD9|NM_001142393|3'UTR
   1 GAAGAAAAAAAAGAGGAAGGGGACTGCGTTAACGGTTACTAAGGAAAACTGGAAATACTGTCTGGTTTTTGTAAATGTTA
  81 TCTATTTTTGTAGATATTTTATATAAAAATGAAATATTTTAACATTTTATGGGTCAGTCAACTTTCAGAAATTCAGGGAG
 161 CTGGAGAGGGAAATCTTTTTTTTTCCCCCTGAGTGGTTCTTATGTATACATAGAAGTATCTGAGACATAAACTGTACAGA
 241 AAACTTGTCCACGTGCTTTTGTATGCCCATGTATTCATGTTTGTTTGTAGATGTTTGTCTGATGCATTTCATTAAAAAAA
 321 AAACCATGAATTACGAAGCACCTTAGTAAGCACCTTCTAATGCTGCATTTTTTTTGTTGTTGTTAAAAACATACCAGCTG
 401 GTTATAATATTGTTCTCCACGTCCTTGTGATGATTCTGAGCCTGGCACTCCCAAATCTGGGAAGCATAGTTTATTTGCAA
 481 GTGTTCACCTTCCAAATCATGAGGCATAGCATGACTTATTCTTGTTTGGAAAACTCTTTTCAAAACTGACCATCTTAAAC
 561 ACATGATGGCCAAGTGCCCAAAAGCCCTCTTGCGGAGCAAATTTCAGAATATATATGTGGATCCAAGCTCTGATAGTTCA
 641 GGTGCTGGAGGGAAGAGAGACCTGTGTGTTTAGAGGCCAGGACCACAGTTAGGATTGGGTTGTTTCAATACTGAGAGACA
 721 GCTACAATAAAAGGAGAGCAATTGCCTCCCTGGGGCTGTTCAATCTTCTGCATTTGTGAGTGGTTCAGTCATGAGGTTTT
 801 CCAAAAGATGTTTTTAGAGTTGTAAAAACCATATTTGCAGCAAAGATTTACAAAGGCGTATCAGACTATGATTGTTCACC
 881 AAAATAGGGGAATGGTTTGATCCGCCAGTTGCAAGTAGAGGCCTTTCTGACTCTTAATATTCACTTTGGTGCTACTACCC
 961 CCATTACCTGAGGGAAACTGGCCAGGTCCTTGATCATGGAACTATAGAGCTACCAGGACATATCCTGCTCTCTAAGGGAA
1041 TTTATTGCTATCTTGCACCTTCTTTAAAACTCACATATGCAGACCTGACACTCAAGAGTGGCTAGCTACACAGAGTCCAT
1121 CTAATTTTTGCAACTTCCTGTGGCCAGTGTGTATAACCCCTTCCACTATCTCACAGATAGTCACAGCGTCCATTCCATAG
1201 TCTGTCTCCTCACATCTGTTAGTATTGACACAGCACAGACACCACAAGCCATCAGGTTCTTCATGGGGCAGGTGAAATAC
1281 TTCTACCCCATGGGTAAATGTATTCACATATTACCAAGAGAAGAAGCACATTATCTATGATCTTTTGGCCCAGTTCTTAT
1361 TTAGCATTTTTATTCCAGCCTACTTGGAAACATGTTTTTATTTGCAATATATGCCTGACTGAATTAAGCTTGCTTGTTTT
1441 AAACAACCAAATCATTGGAACAGAAAAGGATTTAAAAAACAAGAATGCATGATCTCAGAGTGATTAAAAAAAAATCAGTG
1521 GAAATAAATGATCATAGAAGGTGCTTTTCAAAACAACTGCTATTATAATTCTCAAAGTCCTACTCTGCCAAAAGAAGATT
1601 AAAAGTCATACATTACATTACAAGGAAATGTTCATGTGGGAAGAGGGTTGCTGAAAATCAACAACGCTTGAAGTTAAAAA
1681 GTGTGTCTTTGTAGATTTCATTGTATAATGTGTATTTCTTAGGAGATGGCTGACTTGATTGATCTACGCTAAGTGGAGAC
1761 ATTTCACATTTTTAAAACCAAATGTTCAATCTGTATTACTCTTTGCCGTCTTGTATGTAGAGGCTATTTTTAAATCATTA
1841 AATTTTTAGATCTCTGTTTTCATAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' gaCACCCUCGGUGUCCC-ACGAc 5'
            ||||||   | |||| |||| 
Target 5' atGTGGGA---AGAGGGTTGCTg 3'
 1634 - 1653 133.00 -24.20
2 
miRNA  3' gacaccCUCGGUGUCCCACGAc 5'
                ||  : ||||| ||| 
Target 5' ctttcaGAAATTCAGGGAGCTg 3'
 142 - 163 120.00 -14.70
3 
miRNA  3' gacacccucggugucCCACGAc 5'
                         |||||| 
Target 5' agctctgatagttcaGGTGCTg 3'
 626 - 647 120.00 -17.90
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN31527199 4 COSMIC
COSN31574585 4 COSMIC
COSN26986280 5 COSMIC
COSN6588142 9 COSMIC
COSN30109513 19 COSMIC
COSN30587218 24 COSMIC
COSN31554061 27 COSMIC
COSN31503064 44 COSMIC
COSN30473385 82 COSMIC
COSN24296987 176 COSMIC
COSN7593971 185 COSMIC
COSN26637435 252 COSMIC
COSN28977317 313 COSMIC
COSN27262685 314 COSMIC
COSN31528116 329 COSMIC
COSN27163693 367 COSMIC
COSN24301408 420 COSMIC
COSN28693057 594 COSMIC
COSN7593970 768 COSMIC
COSN22415312 831 COSMIC
COSN32062633 1216 COSMIC
COSN19588099 1707 COSMIC
COSN26320049 1707 COSMIC
rs1803710 528 GWAS
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs780525224 1 dbSNP
rs770277455 4 dbSNP
rs1470227702 5 dbSNP
rs746133055 10 dbSNP
rs753570538 13 dbSNP
rs766169691 13 dbSNP
rs1253465294 15 dbSNP
rs1225686725 25 dbSNP
rs781587457 27 dbSNP
rs757514716 28 dbSNP
rs751664786 33 dbSNP
rs145388869 34 dbSNP
rs758421970 35 dbSNP
rs903674901 39 dbSNP
rs374787385 40 dbSNP
rs180880727 43 dbSNP
rs759308682 47 dbSNP
rs753576830 48 dbSNP
rs1020842797 62 dbSNP
rs1418433573 77 dbSNP
rs1186727843 79 dbSNP
rs768311652 84 dbSNP
rs1442539489 86 dbSNP
rs986656932 90 dbSNP
rs954826654 93 dbSNP
rs1430907420 94 dbSNP
rs547676229 95 dbSNP
rs1290250643 97 dbSNP
rs1376531473 101 dbSNP
rs1294326246 103 dbSNP
rs532786782 108 dbSNP
rs1337527001 117 dbSNP
rs1030710947 120 dbSNP
rs1009427873 128 dbSNP
rs1227074774 129 dbSNP
rs370393092 129 dbSNP
rs10601 138 dbSNP
rs749784243 139 dbSNP
rs1341038876 147 dbSNP
rs1235878097 158 dbSNP
rs1057130745 164 dbSNP
rs1483064901 175 dbSNP
rs938799769 181 dbSNP
rs189352525 182 dbSNP
rs369140781 183 dbSNP
rs73723906 184 dbSNP
rs1160666934 185 dbSNP
rs1400723494 185 dbSNP
rs1411223766 185 dbSNP
rs1354626829 190 dbSNP
rs1491462295 190 dbSNP
rs1016500469 191 dbSNP
rs1284176969 191 dbSNP
rs1313169242 191 dbSNP
rs1357726447 192 dbSNP
rs931486897 194 dbSNP
rs1288257720 203 dbSNP
rs1911 211 dbSNP
rs1306246243 212 dbSNP
rs184757303 213 dbSNP
rs535524763 221 dbSNP
rs1908 234 dbSNP
rs912252760 245 dbSNP
rs986472978 246 dbSNP
rs1486520359 251 dbSNP
rs540862038 252 dbSNP
rs1046463013 253 dbSNP
rs1470491242 255 dbSNP
rs577004405 269 dbSNP
rs140279536 275 dbSNP
rs1422424060 284 dbSNP
rs549779714 286 dbSNP
rs979124722 288 dbSNP
rs1411320922 303 dbSNP
rs1162660042 314 dbSNP
rs892373793 319 dbSNP
rs967886140 323 dbSNP
rs1273622958 324 dbSNP
rs376554983 324 dbSNP
rs532988994 324 dbSNP
rs1179401357 326 dbSNP
rs1482421030 328 dbSNP
rs1252113362 334 dbSNP
rs751639187 335 dbSNP
rs1009480276 346 dbSNP
rs1272054918 348 dbSNP
rs181824747 361 dbSNP
rs1289605844 364 dbSNP
rs933379084 368 dbSNP
rs1035315867 373 dbSNP
rs1193728730 374 dbSNP
rs923395658 376 dbSNP
rs972463283 376 dbSNP
rs1337599704 379 dbSNP
rs1286927741 382 dbSNP
rs1002879371 401 dbSNP
rs1227895620 404 dbSNP
rs1441638071 415 dbSNP
rs1351158974 417 dbSNP
rs905835986 420 dbSNP
rs77948513 421 dbSNP
rs564084451 438 dbSNP
rs1434576312 443 dbSNP
rs1347962055 447 dbSNP
rs1216170706 453 dbSNP
rs958955348 460 dbSNP
rs1322672557 466 dbSNP
rs1034891246 467 dbSNP
rs931372308 477 dbSNP
rs575991841 498 dbSNP
rs767039325 501 dbSNP
rs1463190441 524 dbSNP
rs1803710 528 dbSNP
rs1373351767 539 dbSNP
rs906244698 543 dbSNP
rs1161831531 552 dbSNP
rs1472005309 554 dbSNP
rs1417722079 558 dbSNP
rs879081142 562 dbSNP
rs940298484 564 dbSNP
rs189037853 570 dbSNP
rs1328578683 581 dbSNP
rs527602501 590 dbSNP
rs41271643 593 dbSNP
rs12211539 594 dbSNP
rs1328443573 610 dbSNP
rs1245708854 613 dbSNP
rs1214710634 614 dbSNP
rs1432561150 616 dbSNP
rs1053693199 618 dbSNP
rs1266836957 625 dbSNP
rs1233788781 632 dbSNP
rs1275042709 637 dbSNP
rs936536327 640 dbSNP
rs1204049412 646 dbSNP
rs920917229 661 dbSNP
rs1448399689 662 dbSNP
rs979175558 663 dbSNP
rs967770007 665 dbSNP
rs1167733065 668 dbSNP
rs1330003476 672 dbSNP
rs1020779003 675 dbSNP
rs1217493821 677 dbSNP
rs889057557 683 dbSNP
rs1387367707 686 dbSNP
rs1394534902 692 dbSNP
rs1367181189 695 dbSNP
rs987942800 699 dbSNP
rs78168915 702 dbSNP
rs562678339 707 dbSNP
rs923333513 712 dbSNP
rs972214983 713 dbSNP
rs1352280200 721 dbSNP
rs940687917 722 dbSNP
rs1279246055 726 dbSNP
rs571897809 741 dbSNP
rs1002501895 744 dbSNP
rs112250019 753 dbSNP
rs1022952143 754 dbSNP
rs1345324924 758 dbSNP
rs1160673093 763 dbSNP
rs995627700 772 dbSNP
rs545909954 775 dbSNP
rs868430490 801 dbSNP
rs1424067391 814 dbSNP
rs982003653 814 dbSNP
rs1464664005 820 dbSNP
rs1193821589 823 dbSNP
rs1173230250 830 dbSNP
rs1455887269 847 dbSNP
rs971611356 851 dbSNP
rs1246571334 855 dbSNP
rs868111404 858 dbSNP
rs1009350818 864 dbSNP
rs184309931 872 dbSNP
rs1262949439 874 dbSNP
rs1390726561 878 dbSNP
rs576798007 903 dbSNP
rs192992764 904 dbSNP
rs3734400 914 dbSNP
rs1213421823 922 dbSNP
rs920970683 927 dbSNP
rs1319944082 928 dbSNP
rs1480540597 937 dbSNP
rs1372995052 944 dbSNP
rs1006880722 957 dbSNP
rs1043366701 957 dbSNP
rs946352409 958 dbSNP
rs866406440 961 dbSNP
rs1362578378 970 dbSNP
rs1290516289 982 dbSNP
rs913656246 983 dbSNP
rs370226852 1007 dbSNP
rs997756904 1016 dbSNP
rs1455762701 1023 dbSNP
rs529736445 1024 dbSNP
rs988272641 1030 dbSNP
rs1352515149 1056 dbSNP
rs1173952322 1057 dbSNP
rs1298667192 1070 dbSNP
rs188016802 1073 dbSNP
rs960584091 1076 dbSNP
rs116463062 1083 dbSNP
rs1387874731 1085 dbSNP
rs1438002864 1090 dbSNP
rs148200927 1101 dbSNP
rs564751293 1105 dbSNP
rs1371219233 1108 dbSNP
rs969706470 1108 dbSNP
rs909319789 1111 dbSNP
rs1295029615 1112 dbSNP
rs1307265801 1113 dbSNP
rs1228627606 1116 dbSNP
rs1023004258 1118 dbSNP
rs995513075 1119 dbSNP
rs962661618 1137 dbSNP
rs1015702633 1145 dbSNP
rs1487809772 1159 dbSNP
rs1264511489 1168 dbSNP
rs1213095136 1171 dbSNP
rs1049022011 1178 dbSNP
rs937371169 1187 dbSNP
rs1004694477 1188 dbSNP
rs1258306139 1190 dbSNP
rs1427643614 1197 dbSNP
rs891319946 1198 dbSNP
rs1051701233 1201 dbSNP
rs997142529 1208 dbSNP
rs1340314336 1216 dbSNP
rs1164190400 1220 dbSNP
rs543270965 1222 dbSNP
rs575933058 1225 dbSNP
rs1394538160 1227 dbSNP
rs900103133 1231 dbSNP
rs1286695441 1236 dbSNP
rs754517195 1245 dbSNP
rs554893766 1248 dbSNP
rs1274108274 1249 dbSNP
rs913364008 1250 dbSNP
rs114281811 1268 dbSNP
rs572437387 1271 dbSNP
rs946404735 1272 dbSNP
rs956417720 1281 dbSNP
rs1307810685 1284 dbSNP
rs1274423491 1288 dbSNP
rs1297695307 1290 dbSNP
rs375241758 1291 dbSNP
rs1394216250 1295 dbSNP
rs777681950 1302 dbSNP
rs1570372 1305 dbSNP
rs1241677924 1307 dbSNP
rs540052841 1310 dbSNP
rs1312974625 1318 dbSNP
rs1416018158 1320 dbSNP
rs143011276 1325 dbSNP
rs1164110043 1327 dbSNP
rs927858178 1335 dbSNP
rs1306976423 1337 dbSNP
rs981003482 1349 dbSNP
rs1344187550 1353 dbSNP
rs1453976843 1370 dbSNP
rs35047185 1372 dbSNP
rs1462862736 1391 dbSNP
rs1290304468 1393 dbSNP
rs1029318920 1414 dbSNP
rs997409573 1415 dbSNP
rs1375111694 1418 dbSNP
rs1163368330 1419 dbSNP
rs1222105420 1425 dbSNP
rs1283683619 1428 dbSNP
rs1317650856 1429 dbSNP
rs1218176202 1434 dbSNP
rs901761035 1445 dbSNP
rs1004685631 1447 dbSNP
rs184690520 1463 dbSNP
rs1476157513 1469 dbSNP
rs920511776 1470 dbSNP
rs1175459062 1474 dbSNP
rs1044408 1483 dbSNP
rs567952801 1484 dbSNP
rs866720684 1485 dbSNP
rs1419222397 1487 dbSNP
rs937334817 1489 dbSNP
rs1373256524 1490 dbSNP
rs1044411 1492 dbSNP
rs1313904694 1493 dbSNP
rs13849 1499 dbSNP
rs950288711 1500 dbSNP
rs398109840 1506 dbSNP
rs913489721 1506 dbSNP
rs560819231 1511 dbSNP
rs1348750019 1515 dbSNP
rs34467611 1515 dbSNP
rs1242264270 1520 dbSNP
rs973290891 1533 dbSNP
rs1202349756 1542 dbSNP
rs962735355 1560 dbSNP
rs1480641171 1573 dbSNP
rs1015995134 1578 dbSNP
rs1178437878 1584 dbSNP
rs547139500 1586 dbSNP
rs1234623933 1588 dbSNP
rs1173937382 1590 dbSNP
rs925023196 1595 dbSNP
rs1348066592 1599 dbSNP
rs1287377486 1605 dbSNP
rs867034476 1607 dbSNP
rs979210336 1608 dbSNP
rs955637073 1611 dbSNP
rs953258288 1615 dbSNP
rs1444413189 1617 dbSNP
rs1029713808 1619 dbSNP
rs1323992571 1623 dbSNP
rs1028618335 1634 dbSNP
rs1235257678 1636 dbSNP
rs532084751 1637 dbSNP
rs1457658222 1645 dbSNP
rs1346842286 1646 dbSNP
rs1395893301 1665 dbSNP
rs1167669307 1666 dbSNP
rs1438357922 1674 dbSNP
rs1199929917 1683 dbSNP
rs1250576062 1690 dbSNP
rs965960532 1706 dbSNP
rs1193877230 1707 dbSNP
rs149221353 1709 dbSNP
rs539559083 1712 dbSNP
rs1474591252 1716 dbSNP
rs1004654393 1717 dbSNP
rs887649430 1718 dbSNP
rs1027685547 1719 dbSNP
rs1393823293 1722 dbSNP
rs899987118 1739 dbSNP
rs1324915949 1746 dbSNP
rs1328102695 1746 dbSNP
rs1022516789 1747 dbSNP
rs1182874100 1748 dbSNP
rs377304313 1753 dbSNP
rs1220361335 1754 dbSNP
rs1421124198 1755 dbSNP
rs1045706000 1766 dbSNP
rs1011099699 1772 dbSNP
rs1213788749 1778 dbSNP
rs892155384 1789 dbSNP
rs1291526098 1790 dbSNP
rs1052526949 1792 dbSNP
rs950126070 1803 dbSNP
rs1243021502 1805 dbSNP
rs1479044695 1806 dbSNP
rs892036209 1807 dbSNP
rs1044417 1808 dbSNP
rs936147364 1833 dbSNP
rs1165104457 1834 dbSNP
rs926078166 1842 dbSNP
rs986034850 1848 dbSNP
rs575872697 1849 dbSNP
rs561008830 1854 dbSNP
rs1401680278 1856 dbSNP
rs1354772595 1864 dbSNP
rs192401291 1865 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions TZM-bl
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM1462574. RNA binding protein: AGO2. Condition:TZM-bl ami BaL ...

- Whisnant AW; Bogerd HP; Flores O; Ho P; et al., 2013, mBio.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' gacacccucggugucCCACGAc 5'
                         |||||| 
Target 5' cuuaauauucacuuuGGUGCUa 3'
 		4 - 25
Article - Whisnant AW; Bogerd HP; Flores O; Ho P; et al.
- mBio, 2013
UNLABELLED: The question of how HIV-1 interfaces with cellular microRNA (miRNA) biogenesis and effector mechanisms has been highly controversial. Here, we first used deep sequencing of small RNAs present in two different infected cell lines (TZM-bl and C8166) and two types of primary human cells (CD4(+) peripheral blood mononuclear cells [PBMCs] and macrophages) to unequivocally demonstrate that HIV-1 does not encode any viral miRNAs. Perhaps surprisingly, we also observed that infection of T cells by HIV-1 has only a modest effect on the expression of cellular miRNAs at early times after infection. Comprehensive analysis of miRNA binding to the HIV-1 genome using the photoactivatable ribonucleoside-induced cross-linking and immunoprecipitation (PAR-CLIP) technique revealed several binding sites for cellular miRNAs, a subset of which were shown to be capable of mediating miRNA-mediated repression of gene expression. However, the main finding from this analysis is that HIV-1 transcripts are largely refractory to miRNA binding, most probably due to extensive viral RNA secondary structure. Together, these data demonstrate that HIV-1 neither encodes viral miRNAs nor strongly influences cellular miRNA expression, at least early after infection, and imply that HIV-1 transcripts have evolved to avoid inhibition by preexisting cellular miRNAs by adopting extensive RNA secondary structures that occlude most potential miRNA binding sites. IMPORTANCE: MicroRNAs (miRNAs) are a ubiquitous class of small regulatory RNAs that serve as posttranscriptional regulators of gene expression. Previous work has suggested that HIV-1 might subvert the function of the cellular miRNA machinery by expressing viral miRNAs or by dramatically altering the level of cellular miRNA expression. Using very sensitive approaches, we now demonstrate that neither of these ideas is in fact correct. Moreover, HIV-1 transcripts appear to largely avoid regulation by cellular miRNAs by adopting an extensive RNA secondary structure that occludes the ability of cellular miRNAs to interact with viral mRNAs. Together, these data suggest that HIV-1, rather than seeking to control miRNA function in infected cells, has instead evolved a mechanism to become largely invisible to cellular miRNA effector mechanisms.
LinkOut: [PMID: 23592263]
CLIP-seq Support 1 for dataset GSM1462574
Method / RBP PAR-CLIP / AGO2
Cell line / Condition TZM-bl / TZM-bl ami BaL
Location of target site ENST00000379446.5 | 3UTR | ACUCUUAAUAUUCACUUUGGUGCUACUACCCCCAUUACCUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23592263 / GSE59944
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
88 hsa-miR-6871-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT061678 BTG2 BTG anti-proliferation factor 2 2 4
MIRT116181 NUFIP2 NUFIP2, FMR1 interacting protein 2 2 2
MIRT150139 MIDN midnolin 2 2
MIRT197058 NKIRAS2 NFKB inhibitor interacting Ras like 2 2 2
MIRT225108 GOLGA7 golgin A7 2 2
MIRT376288 CALM3 calmodulin 3 2 2
MIRT454810 NEDD9 neural precursor cell expressed, developmentally down-regulated 9 2 2
MIRT464228 VEGFA vascular endothelial growth factor A 2 6
MIRT466961 STAT3 signal transducer and activator of transcription 3 2 2
MIRT468219 SGK1 serum/glucocorticoid regulated kinase 1 2 2
MIRT472460 NASP nuclear autoantigenic sperm protein 2 2
MIRT474203 LEPRE1 prolyl 3-hydroxylase 1 1 1
MIRT475836 HDGF heparin binding growth factor 2 4
MIRT478667 CTC1 CST telomere replication complex component 1 2 14
MIRT478707 CSRNP2 cysteine and serine rich nuclear protein 2 2 2
MIRT478982 COMMD2 COMM domain containing 2 2 2
MIRT479693 CCNT2 cyclin T2 2 6
MIRT488440 ULBP2 UL16 binding protein 2 2 2
MIRT492511 RAET1L retinoic acid early transcript 1L 2 2
MIRT492975 NCS1 neuronal calcium sensor 1 2 2
MIRT494158 COL4A1 collagen type IV alpha 1 chain 2 6
MIRT495934 SLC7A5P2 solute carrier family 7 member 5 pseudogene 2 2 2
MIRT496210 PLEKHG2 pleckstrin homology and RhoGEF domain containing G2 2 2
MIRT496356 PPY pancreatic polypeptide 2 2
MIRT496385 ZC3H6 zinc finger CCCH-type containing 6 2 2
MIRT496463 DCTN5 dynactin subunit 5 2 2
MIRT497642 GLDN gliomedin 2 2
MIRT498496 FRK fyn related Src family tyrosine kinase 2 2
MIRT501928 MCL1 MCL1, BCL2 family apoptosis regulator 2 8
MIRT513286 PDPK1 3-phosphoinositide dependent protein kinase 1 2 2
MIRT514767 RBM4B RNA binding motif protein 4B 2 2
MIRT514916 MDM2 MDM2 proto-oncogene 2 6
MIRT515669 LRRC27 leucine rich repeat containing 27 2 2
MIRT520367 UBE2G2 ubiquitin conjugating enzyme E2 G2 2 2
MIRT523960 DYNLT1 dynein light chain Tctex-type 1 2 4
MIRT526859 KIFC1 kinesin family member C1 2 2
MIRT527673 CASP8 caspase 8 2 2
MIRT527828 TMEM74B transmembrane protein 74B 2 2
MIRT529553 EI24 EI24, autophagy associated transmembrane protein 2 2
MIRT530547 SYNPO synaptopodin 2 2
MIRT531725 TARS threonyl-tRNA synthetase 2 2
MIRT533340 UNC119B unc-119 lipid binding chaperone B 2 2
MIRT533620 TNFRSF13C TNF receptor superfamily member 13C 2 2
MIRT537226 GAN gigaxonin 2 2
MIRT544430 ZNF460 zinc finger protein 460 2 4
MIRT546905 PTP4A1 protein tyrosine phosphatase type IVA, member 1 2 2
MIRT547102 PLAG1 PLAG1 zinc finger 2 2
MIRT547820 ISG20L2 interferon stimulated exonuclease gene 20 like 2 2 2
MIRT548236 FEM1B fem-1 homolog B 2 2
MIRT550034 WWTR1 WW domain containing transcription regulator 1 2 2
MIRT554337 SH3GLB1 SH3 domain containing GRB2 like, endophilin B1 2 4
MIRT565483 SPRTN SprT-like N-terminal domain 2 2
MIRT568200 CBX6 chromobox 6 2 2
MIRT569754 C2orf71 chromosome 2 open reading frame 71 2 2
MIRT571369 ZNF45 zinc finger protein 45 2 2
MIRT609886 CLASP1 cytoplasmic linker associated protein 1 2 4
MIRT640543 C3orf36 chromosome 3 open reading frame 36 2 2
MIRT640885 ENTPD1 ectonucleoside triphosphate diphosphohydrolase 1 2 2
MIRT643494 LRCH3 leucine rich repeats and calponin homology domain containing 3 2 2
MIRT643627 YY2 YY2 transcription factor 2 2
MIRT644384 ZNF286A zinc finger protein 286A 2 2
MIRT646126 SLC26A9 solute carrier family 26 member 9 2 2
MIRT655939 NDUFA4P1 NDUFA4, mitochondrial complex associated pseudogene 1 2 2
MIRT656057 MYLK4 myosin light chain kinase family member 4 2 2
MIRT658767 EIF4EBP2 eukaryotic translation initiation factor 4E binding protein 2 2 2
MIRT661583 EPHX2 epoxide hydrolase 2 2 2
MIRT664285 RNMTL1 mitochondrial rRNA methyltransferase 3 2 2
MIRT689391 ZNF850 zinc finger protein 850 2 2
MIRT694530 TRIM72 tripartite motif containing 72 2 2
MIRT694626 ZFPM1 zinc finger protein, FOG family member 1 2 2
MIRT695133 PRY2 PTPN13-like, Y-linked 2 2 2
MIRT695150 PRY PTPN13-like, Y-linked 2 2
MIRT697468 ZC3H4 zinc finger CCCH-type containing 4 2 2
MIRT701919 MLXIP MLX interacting protein 2 2
MIRT704548 CNBP CCHC-type zinc finger nucleic acid binding protein 2 2
MIRT704791 CDK6 cyclin dependent kinase 6 2 2
MIRT705696 ANKRD13A ankyrin repeat domain 13A 2 2
MIRT707992 OTUD4 OTU deubiquitinase 4 2 2
MIRT708739 FAM71F2 family with sequence similarity 71 member F2 2 2
MIRT713401 FAM179A TOG array regulator of axonemal microtubules 2 2 2
MIRT713846 FAM3D family with sequence similarity 3 member D 2 2
MIRT716998 ARL6IP4 ADP ribosylation factor like GTPase 6 interacting protein 4 2 2
MIRT718511 DIRAS1 DIRAS family GTPase 1 2 2
MIRT718698 BTBD9 BTB domain containing 9 2 2
MIRT719578 TYRO3 TYRO3 protein tyrosine kinase 2 2
MIRT720892 CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 2 2
MIRT722633 C8A complement C8 alpha chain 2 2
MIRT723333 DGAT1 diacylglycerol O-acyltransferase 1 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-6871-3p Gefitinib 123631 NSC715055 approved resistant cell line (HCC827)
hsa-miR-6871-3p Osimertinib 71496458 NSC779217 approved resistant cell line (PC9)
hsa-miR-6871-3p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-6871-3p Gefitinib 123631 NSC715055 approved resistant cell line (HCC827)

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