pre-miRNA Information
pre-miRNA hsa-mir-4747   
Genomic Coordinates chr19: 4932687 - 4932740
Description Homo sapiens miR-4747 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-4747-5p
Sequence 1| AGGGAAGGAGGCUUGGUCUUAG |22
Evidence Experimental
Experiments Illumina
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs560927363 4 dbSNP
rs1471226927 10 dbSNP
rs763137545 12 dbSNP
rs767337154 15 dbSNP
rs775298039 16 dbSNP
rs760472311 19 dbSNP
rs1207950315 21 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol ARHGAP39   
Synonyms CrGAP, Vilse
Description Rho GTPase activating protein 39
Transcript NM_025251   
Expression
Putative miRNA Targets on ARHGAP39
3'UTR of ARHGAP39
(miRNA target sites are highlighted)
>ARHGAP39|NM_025251|3'UTR
   1 CGGGGGCGCCCGGGGACAGGAGGGATGTCCTGCCGCCCCCAGCCAGGCCGAACTCCGCACTCGCTCTCCCGGCAGAGGGG
  81 CCAGAATCGCCCGGCCCAGCCCTGGAGCCCCCTCCACTCCCCCAGGCCCCTGGCCCCGGCGCTCCCCACGTCTTCTGCCT
 161 GGTCTGAGGGTGCAGCCAGGGCACAGCAGCGGCGGGGAGGGCGCCTCTGGCCCCCCACCTCACGGCCAGTTCCCGCGGGC
 241 ACCGCCTCGCCCTCCGCTGGCCGCGGGTCAGCTCCGAGAAAGTGCCTTCTGTGTCCTGGAGCCGAGCGACGCTGCCTCCT
 321 TGGGGCCGGGCTGCCTCCCTGTGGCTCCTGCGCGCCCTGGCCTGGGCCTTGCCCAGCCGCCCCGGTCTCTCCTTCCCTTT
 401 CTCCTGTCCTCGTCCTGGCCTGCAGCTCTTCCCAGCCCCGAGAGAGCTTCCCGACCTGTCCCCGCCTCCTCTCCCTCCCT
 481 CGGCCCGTGGTCCCCAGCTGGTGACTGCTCAGGAGTTTGGGGGCTCCAGGACAGTGGGCCCGGGGCCTGGCAGGCTCTCG
 561 GTGGGTGGGGTGGGGGCCCCCAAACCAAAGTCCTCTGGGGTAGGGAGCAGGGCTGGGCAGGCATTCTGGGGGCAGGGTGG
 641 GGGAGGGGCGAGAGTATTTTTTTCTTCGTGTAACTGTAAATCCAGAATCTATCCTGCATCGCAGCCCACCGTGTATAGAG
 721 ATATAAATAGAGGGAAAGATATAAGAACTAAATTTGCTAATGACATAGTTTTAACCTAAATGCTATTTATCTCTGAGCCG
 801 TCCCCGTCCTCCGTGCAGAGCAAGTTGAGGTCATTCCTTCTTTTCTTCTCCGATCTTTTTTCTTGGCTTCTGACCAAAAA
 881 CCAAGCTCTACCCCATCCCCATCCCAGACCTGCAGGAGACGAGCGAGCGGGAAGGCGCCGGGCCCGGGACTGTCCGTTCT
 961 CGGGGCCAGAGCTGCTGGGGGACCGAGTTTGTACATTTTCCATTTTGGAATTTTGAGTTCCAATTGTTGTAAAACTTAAT
1041 TTCTCCCCAGTTTTTATATATATATTTTTTAGAGTTCCGTTTTTATTTATTAAAAACAAAAGCCCCAGCCCTGCCGAGGC
1121 CTGGGCGGCGTCCTCAGTCGGGTGGTCCCGGGGCCTTTGCGGTCCCGCCCGGCTGAGACGCTCGCCCCGACGCATGGACC
1201 CGAGAGGCGACGACACGAGTGAATAAAGTGCACATGGACCCTGAAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' gauuCUGGUUC--GGAGGAAGGGa 5'
              | || :|  :||||||||| 
Target 5' agccGCCCCGGTCTCTCCTTCCCt 3'
375 - 398 156.00 -22.30
2
miRNA  3' gaUUCUGGUUCG-GA---GGAAGGGa 5'
            || ||||||| ||   || |||| 
Target 5' caAAAACCAAGCTCTACCCCATCCCc 3'
875 - 900 140.00 -17.90
3
miRNA  3' gauuCUGGUUCGGA-----GGAAGGGa 5'
              | || :||||     :|||||| 
Target 5' cctcGTCCTGGCCTGCAGCTCTTCCCa 3'
408 - 434 138.00 -16.90
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30118080 4 COSMIC
COSN30477309 10 COSMIC
COSN31480651 75 COSMIC
COSN14825004 116 COSMIC
COSN30126699 140 COSMIC
COSN8074328 244 COSMIC
COSN22890953 361 COSMIC
COSN24593045 439 COSMIC
COSN24490161 504 COSMIC
COSN20091882 540 COSMIC
COSN22432240 775 COSMIC
COSN27474996 832 COSMIC
COSN32116662 1202 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs199861857 2 dbSNP
rs376486769 3 dbSNP
rs200191602 4 dbSNP
rs1433113131 5 dbSNP
rs779114975 6 dbSNP
rs755419370 9 dbSNP
rs1448434603 12 dbSNP
rs1456087654 14 dbSNP
rs754099493 15 dbSNP
rs780491500 16 dbSNP
rs1341106359 18 dbSNP
rs1457998126 22 dbSNP
rs1162172903 23 dbSNP
rs1052034699 25 dbSNP
rs745906509 25 dbSNP
rs1254022207 27 dbSNP
rs756409961 29 dbSNP
rs1232264175 30 dbSNP
rs1371560950 31 dbSNP
rs368076363 32 dbSNP
rs1443139907 33 dbSNP
rs750473274 34 dbSNP
rs1328333708 35 dbSNP
rs1410737005 37 dbSNP
rs767659192 39 dbSNP
rs933466469 40 dbSNP
rs922104740 43 dbSNP
rs1323768998 46 dbSNP
rs781302056 47 dbSNP
rs752723117 49 dbSNP
rs764923005 50 dbSNP
rs1258207845 54 dbSNP
rs557280896 58 dbSNP
rs1035431875 62 dbSNP
rs535471095 63 dbSNP
rs190879743 64 dbSNP
rs925742475 71 dbSNP
rs1464750180 77 dbSNP
rs1304196618 79 dbSNP
rs372296531 81 dbSNP
rs978817907 83 dbSNP
rs1411089158 84 dbSNP
rs1415024709 87 dbSNP
rs1025273442 94 dbSNP
rs995408611 96 dbSNP
rs1412858869 99 dbSNP
rs992778608 101 dbSNP
rs1455413252 102 dbSNP
rs959822498 105 dbSNP
rs367737984 108 dbSNP
rs1034194018 109 dbSNP
rs377151963 111 dbSNP
rs114845297 112 dbSNP
rs1016378460 117 dbSNP
rs142534226 122 dbSNP
rs552357594 123 dbSNP
rs532824477 131 dbSNP
rs1258198911 132 dbSNP
rs1483371226 133 dbSNP
rs1199537514 134 dbSNP
rs562436455 137 dbSNP
rs1052407164 138 dbSNP
rs1182318858 139 dbSNP
rs1051217642 140 dbSNP
rs1411115237 145 dbSNP
rs1473585294 147 dbSNP
rs997730161 149 dbSNP
rs1359528794 150 dbSNP
rs1466695984 153 dbSNP
rs900795074 155 dbSNP
rs1373672306 156 dbSNP
rs1252642300 158 dbSNP
rs935403127 168 dbSNP
rs1411711993 169 dbSNP
rs1871537 170 dbSNP
rs1043757918 171 dbSNP
rs946965032 172 dbSNP
rs916840830 173 dbSNP
rs1232024992 175 dbSNP
rs1277711594 181 dbSNP
rs1258678657 188 dbSNP
rs1002527450 198 dbSNP
rs1205232457 202 dbSNP
rs990989226 204 dbSNP
rs1201430129 211 dbSNP
rs1350448809 217 dbSNP
rs907470348 217 dbSNP
rs1479577681 223 dbSNP
rs1192866766 225 dbSNP
rs1425550200 239 dbSNP
rs1258534385 243 dbSNP
rs139043473 245 dbSNP
rs928139924 246 dbSNP
rs1042827081 251 dbSNP
rs945681029 255 dbSNP
rs776286021 261 dbSNP
rs992710972 264 dbSNP
rs1368965681 265 dbSNP
rs1440600619 267 dbSNP
rs1301766054 273 dbSNP
rs1343846670 275 dbSNP
rs1342242493 278 dbSNP
rs1228684453 286 dbSNP
rs1334527596 292 dbSNP
rs951148717 295 dbSNP
rs1025241637 301 dbSNP
rs1382535879 302 dbSNP
rs974171634 307 dbSNP
rs773570142 319 dbSNP
rs561755084 322 dbSNP
rs1164366119 324 dbSNP
rs1472079340 327 dbSNP
rs1249731789 328 dbSNP
rs927235208 331 dbSNP
rs746824766 332 dbSNP
rs1418841668 339 dbSNP
rs779797408 342 dbSNP
rs1370665131 344 dbSNP
rs1006724546 345 dbSNP
rs1188883280 346 dbSNP
rs963220747 347 dbSNP
rs955149678 348 dbSNP
rs1016736187 350 dbSNP
rs1004970975 351 dbSNP
rs950740992 352 dbSNP
rs1260096426 354 dbSNP
rs1029507603 356 dbSNP
rs1465112420 357 dbSNP
rs999580150 364 dbSNP
rs1359486455 375 dbSNP
rs900742829 375 dbSNP
rs1290042201 378 dbSNP
rs1321045959 379 dbSNP
rs902616558 380 dbSNP
rs772114503 382 dbSNP
rs1465205639 383 dbSNP
rs1357882901 384 dbSNP
rs1043713528 385 dbSNP
rs1474582839 386 dbSNP
rs1183662263 387 dbSNP
rs1011352495 397 dbSNP
rs1000962468 400 dbSNP
rs904040978 402 dbSNP
rs540496692 403 dbSNP
rs1055746251 404 dbSNP
rs1318136990 408 dbSNP
rs116738744 409 dbSNP
rs1449863980 411 dbSNP
rs1284206089 414 dbSNP
rs1437520781 418 dbSNP
rs1389714754 420 dbSNP
rs1231331534 422 dbSNP
rs1290101525 422 dbSNP
rs928108845 425 dbSNP
rs1204318711 426 dbSNP
rs1403630950 433 dbSNP
rs763237543 434 dbSNP
rs1474940712 439 dbSNP
rs1047903971 440 dbSNP
rs557936597 441 dbSNP
rs918366534 442 dbSNP
rs973759096 444 dbSNP
rs962734359 447 dbSNP
rs772346260 448 dbSNP
rs1158348450 452 dbSNP
rs1406247766 457 dbSNP
rs910889920 462 dbSNP
rs985744564 463 dbSNP
rs1374514308 465 dbSNP
rs1412357560 466 dbSNP
rs955285127 467 dbSNP
rs546029780 468 dbSNP
rs999382149 469 dbSNP
rs966771233 471 dbSNP
rs983722720 474 dbSNP
rs1022834752 475 dbSNP
rs1221111658 477 dbSNP
rs1010904175 478 dbSNP
rs1281271912 479 dbSNP
rs1030853384 486 dbSNP
rs1208806638 490 dbSNP
rs1452776041 491 dbSNP
rs997462088 494 dbSNP
rs940910041 497 dbSNP
rs1181739269 501 dbSNP
rs545436229 504 dbSNP
rs575434690 507 dbSNP
rs1479228118 509 dbSNP
rs895105059 510 dbSNP
rs1173575885 512 dbSNP
rs1394086877 515 dbSNP
rs1055145733 521 dbSNP
rs1003727782 522 dbSNP
rs1001077080 523 dbSNP
rs903986627 526 dbSNP
rs1021115733 527 dbSNP
rs1010188878 529 dbSNP
rs906818499 537 dbSNP
rs1347429005 539 dbSNP
rs557171858 540 dbSNP
rs929507903 541 dbSNP
rs1228819384 545 dbSNP
rs918337746 547 dbSNP
rs1056914519 548 dbSNP
rs1340181481 554 dbSNP
rs1195692827 559 dbSNP
rs60512843 564 dbSNP
rs905529161 567 dbSNP
rs1044301686 576 dbSNP
rs941948703 577 dbSNP
rs909159274 579 dbSNP
rs1190134792 580 dbSNP
rs1390211823 587 dbSNP
rs941130582 592 dbSNP
rs929157431 593 dbSNP
rs534384921 594 dbSNP
rs752930375 595 dbSNP
rs985162946 596 dbSNP
rs1324342900 602 dbSNP
rs1438923613 603 dbSNP
rs1300142019 604 dbSNP
rs1409871439 607 dbSNP
rs1327291112 608 dbSNP
rs1226764110 613 dbSNP
rs1249754357 620 dbSNP
rs955257725 626 dbSNP
rs1214873410 628 dbSNP
rs1369285890 634 dbSNP
rs568329980 636 dbSNP
rs1261972866 637 dbSNP
rs933487197 637 dbSNP
rs1427618632 638 dbSNP
rs977912508 647 dbSNP
rs968326370 652 dbSNP
rs1475463659 654 dbSNP
rs1021649510 655 dbSNP
rs552971909 656 dbSNP
rs1321043723 660 dbSNP
rs1381863991 665 dbSNP
rs1430745359 665 dbSNP
rs1022131459 667 dbSNP
rs1293445977 668 dbSNP
rs896664592 670 dbSNP
rs141687296 678 dbSNP
rs1394868328 683 dbSNP
rs781483737 684 dbSNP
rs1210957044 687 dbSNP
rs959502394 688 dbSNP
rs1485303219 692 dbSNP
rs1034076971 693 dbSNP
rs375870879 694 dbSNP
rs1180521649 695 dbSNP
rs576430822 700 dbSNP
rs906784322 702 dbSNP
rs1159475684 705 dbSNP
rs1363021514 706 dbSNP
rs1002631635 708 dbSNP
rs1026562130 710 dbSNP
rs570819852 711 dbSNP
rs1404668999 712 dbSNP
rs1044080423 716 dbSNP
rs552495058 718 dbSNP
rs993711329 720 dbSNP
rs1230778777 721 dbSNP
rs941713840 722 dbSNP
rs1316724457 723 dbSNP
rs1346792499 724 dbSNP
rs531008520 729 dbSNP
rs887686642 730 dbSNP
rs899297850 732 dbSNP
rs1257367122 733 dbSNP
rs1485823939 733 dbSNP
rs1048123011 734 dbSNP
rs929133357 737 dbSNP
rs141813045 738 dbSNP
rs550391749 742 dbSNP
rs943449414 747 dbSNP
rs1417049447 749 dbSNP
rs1178025035 754 dbSNP
rs1397101507 757 dbSNP
rs528997272 767 dbSNP
rs558158896 768 dbSNP
rs889568284 769 dbSNP
rs1441520665 775 dbSNP
rs910676164 776 dbSNP
rs1049412485 783 dbSNP
rs561495452 785 dbSNP
rs979439757 788 dbSNP
rs762017990 789 dbSNP
rs1310330718 791 dbSNP
rs933679223 792 dbSNP
rs371288035 802 dbSNP
rs1375217557 803 dbSNP
rs977964743 808 dbSNP
rs945288973 809 dbSNP
rs1415790018 811 dbSNP
rs915034874 812 dbSNP
rs960830378 821 dbSNP
rs2620649 825 dbSNP
rs138692736 829 dbSNP
rs564362126 830 dbSNP
rs546165715 835 dbSNP
rs959707367 836 dbSNP
rs1471289962 837 dbSNP
rs1192704750 840 dbSNP
rs1253400832 843 dbSNP
rs568599243 848 dbSNP
rs575323873 848 dbSNP
rs1228815122 851 dbSNP
rs1171286819 852 dbSNP
rs1033801556 853 dbSNP
rs969775346 855 dbSNP
rs1460919542 858 dbSNP
rs113488941 860 dbSNP
rs982074373 862 dbSNP
rs1372204321 868 dbSNP
rs970661608 870 dbSNP
rs1358458021 874 dbSNP
rs1485334751 880 dbSNP
rs1300764431 893 dbSNP
rs563532721 903 dbSNP
rs1235504883 906 dbSNP
rs1271756838 907 dbSNP
rs1005855044 908 dbSNP
rs1212027566 909 dbSNP
rs1026278708 916 dbSNP
rs541930346 921 dbSNP
rs1279541812 924 dbSNP
rs899434894 924 dbSNP
rs1016828783 925 dbSNP
rs1211635236 926 dbSNP
rs1007757066 928 dbSNP
rs1047603116 929 dbSNP
rs889527890 941 dbSNP
rs1049545615 942 dbSNP
rs1167772129 944 dbSNP
rs187567154 946 dbSNP
rs900805249 952 dbSNP
rs115814584 955 dbSNP
rs572914680 958 dbSNP
rs1450571652 962 dbSNP
rs534690118 967 dbSNP
rs1360122234 969 dbSNP
rs1431021125 972 dbSNP
rs1269023363 981 dbSNP
rs1359283089 982 dbSNP
rs943229985 983 dbSNP
rs1293803696 984 dbSNP
rs1334134670 990 dbSNP
rs915189833 995 dbSNP
rs1231214798 1000 dbSNP
rs1269862934 1004 dbSNP
rs1317113012 1008 dbSNP
rs1455374078 1014 dbSNP
rs1448895401 1015 dbSNP
rs1054019058 1018 dbSNP
rs576875885 1023 dbSNP
rs926458995 1025 dbSNP
rs1484914388 1026 dbSNP
rs1411487571 1031 dbSNP
rs1190212587 1032 dbSNP
rs1419194404 1037 dbSNP
rs111567232 1044 dbSNP
rs1475204913 1045 dbSNP
rs1163143233 1046 dbSNP
rs946698588 1047 dbSNP
rs1183553123 1050 dbSNP
rs913898672 1052 dbSNP
rs1472971892 1054 dbSNP
rs982125206 1056 dbSNP
rs970801955 1057 dbSNP
rs960944465 1058 dbSNP
rs1281020214 1063 dbSNP
rs928223101 1064 dbSNP
rs919238799 1065 dbSNP
rs969556528 1066 dbSNP
rs980920579 1066 dbSNP
rs1351853211 1071 dbSNP
rs972064219 1078 dbSNP
rs1209393678 1082 dbSNP
rs766787639 1084 dbSNP
rs1186453362 1086 dbSNP
rs1016551782 1089 dbSNP
rs1450488621 1092 dbSNP
rs758940718 1100 dbSNP
rs1158405388 1102 dbSNP
rs1382152533 1103 dbSNP
rs879273799 1105 dbSNP
rs1230528854 1107 dbSNP
rs901750091 1109 dbSNP
rs1040298125 1115 dbSNP
rs953533329 1117 dbSNP
rs1330768817 1118 dbSNP
rs558804730 1119 dbSNP
rs1030512697 1123 dbSNP
rs1441190218 1126 dbSNP
rs997911096 1130 dbSNP
rs1432410545 1132 dbSNP
rs888951178 1134 dbSNP
rs749909836 1149 dbSNP
rs1042061440 1161 dbSNP
rs1347285362 1165 dbSNP
rs1198841921 1169 dbSNP
rs946782426 1171 dbSNP
rs1347628528 1172 dbSNP
rs537786461 1175 dbSNP
rs570113065 1180 dbSNP
rs1009268114 1184 dbSNP
rs184108569 1185 dbSNP
rs893711107 1186 dbSNP
rs116480921 1188 dbSNP
rs1186497064 1194 dbSNP
rs928170920 1195 dbSNP
rs1396439176 1196 dbSNP
rs1443329486 1199 dbSNP
rs981036911 1200 dbSNP
rs1250081285 1206 dbSNP
rs948165132 1208 dbSNP
rs1189469992 1211 dbSNP
rs937931851 1212 dbSNP
rs149527055 1213 dbSNP
rs1224406840 1215 dbSNP
rs1322899880 1217 dbSNP
rs1274323515 1220 dbSNP
rs1194613020 1225 dbSNP
rs1226602846 1230 dbSNP
rs745405372 1231 dbSNP
rs1026088481 1232 dbSNP
rs778609369 1233 dbSNP
rs949455770 1234 dbSNP
rs1461751596 1235 dbSNP
rs919373187 1237 dbSNP
rs1394025800 1240 dbSNP
rs79956544 1243 dbSNP
rs1320308665 1244 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions TZM-bl
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM1462574. RNA binding protein: AGO2. Condition:TZM-bl ami BaL ...

- Whisnant AW; Bogerd HP; Flores O; Ho P; et al., 2013, mBio.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1
miRNA  3' gauucugguucGGAGGAAGGGa 5'
                     :||||||||| 
Target 5' ----------cUCUCCUUCCCu 3'
1 - 12
Article - Whisnant AW; Bogerd HP; Flores O; Ho P; et al.
- mBio, 2013
UNLABELLED: The question of how HIV-1 interfaces with cellular microRNA (miRNA) biogenesis and effector mechanisms has been highly controversial. Here, we first used deep sequencing of small RNAs present in two different infected cell lines (TZM-bl and C8166) and two types of primary human cells (CD4(+) peripheral blood mononuclear cells [PBMCs] and macrophages) to unequivocally demonstrate that HIV-1 does not encode any viral miRNAs. Perhaps surprisingly, we also observed that infection of T cells by HIV-1 has only a modest effect on the expression of cellular miRNAs at early times after infection. Comprehensive analysis of miRNA binding to the HIV-1 genome using the photoactivatable ribonucleoside-induced cross-linking and immunoprecipitation (PAR-CLIP) technique revealed several binding sites for cellular miRNAs, a subset of which were shown to be capable of mediating miRNA-mediated repression of gene expression. However, the main finding from this analysis is that HIV-1 transcripts are largely refractory to miRNA binding, most probably due to extensive viral RNA secondary structure. Together, these data demonstrate that HIV-1 neither encodes viral miRNAs nor strongly influences cellular miRNA expression, at least early after infection, and imply that HIV-1 transcripts have evolved to avoid inhibition by preexisting cellular miRNAs by adopting extensive RNA secondary structures that occlude most potential miRNA binding sites. IMPORTANCE: MicroRNAs (miRNAs) are a ubiquitous class of small regulatory RNAs that serve as posttranscriptional regulators of gene expression. Previous work has suggested that HIV-1 might subvert the function of the cellular miRNA machinery by expressing viral miRNAs or by dramatically altering the level of cellular miRNA expression. Using very sensitive approaches, we now demonstrate that neither of these ideas is in fact correct. Moreover, HIV-1 transcripts appear to largely avoid regulation by cellular miRNAs by adopting an extensive RNA secondary structure that occludes the ability of cellular miRNAs to interact with viral mRNAs. Together, these data suggest that HIV-1, rather than seeking to control miRNA function in infected cells, has instead evolved a mechanism to become largely invisible to cellular miRNA effector mechanisms.
LinkOut: [PMID: 23592263]
CLIP-seq Support 1 for dataset GSM1462574
Method / RBP PAR-CLIP / AGO2
Cell line / Condition TZM-bl / TZM-bl ami BaL
Location of target site ENST00000377307.2 | 3UTR | CUCUCCUUCCCUUUCUCCUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23592263 / GSE59944
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
215 hsa-miR-4747-5p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT061689 BTG2 BTG anti-proliferation factor 2 2 2
MIRT062834 BCL7A BCL tumor suppressor 7A 2 2
MIRT079371 CCDC137 coiled-coil domain containing 137 2 2
MIRT081190 MIDN midnolin 2 4
MIRT081724 ZNF507 zinc finger protein 507 2 2
MIRT110565 ZMYND11 zinc finger MYND-type containing 11 2 2
MIRT133724 SKI SKI proto-oncogene 2 4
MIRT146689 MINK1 misshapen like kinase 1 2 2
MIRT150676 SLC27A1 solute carrier family 27 member 1 2 2
MIRT159196 NRBP1 nuclear receptor binding protein 1 2 2
MIRT180865 RPRD2 regulation of nuclear pre-mRNA domain containing 2 2 2
MIRT190659 PABPN1 poly(A) binding protein nuclear 1 2 2
MIRT196111 MPRIP myosin phosphatase Rho interacting protein 2 2
MIRT232390 SP1 Sp1 transcription factor 2 2
MIRT331070 EIF5AL1 eukaryotic translation initiation factor 5A-like 1 2 4
MIRT338632 SHMT2 serine hydroxymethyltransferase 2 2 2
MIRT407441 CTDSP1 CTD small phosphatase 1 2 2
MIRT444276 NKX6-1 NK6 homeobox 1 2 2
MIRT444834 PDE6D phosphodiesterase 6D 2 2
MIRT445452 EXT1 exostosin glycosyltransferase 1 2 2
MIRT445644 NPY4R neuropeptide Y receptor Y4 2 2
MIRT446157 RPL12 ribosomal protein L12 2 2
MIRT446608 HIP1 huntingtin interacting protein 1 2 2
MIRT447108 CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit 2 2
MIRT449314 MRO maestro 2 2
MIRT450305 DRAXIN dorsal inhibitory axon guidance protein 2 2
MIRT451245 ZNF444 zinc finger protein 444 2 2
MIRT451714 OLR1 oxidized low density lipoprotein receptor 1 2 2
MIRT451908 ILK integrin linked kinase 2 2
MIRT452183 KIAA1456 KIAA1456 2 2
MIRT452610 REPIN1 replication initiator 1 2 2
MIRT453422 GLG1 golgi glycoprotein 1 2 2
MIRT454006 ALKBH5 alkB homolog 5, RNA demethylase 2 2
MIRT455072 ARHGAP39 Rho GTPase activating protein 39 2 2
MIRT455319 TTLL9 tubulin tyrosine ligase like 9 2 2
MIRT455357 KDM5C lysine demethylase 5C 2 2
MIRT455589 TAF12 TATA-box binding protein associated factor 12 2 2
MIRT455711 EIF4EBP2 eukaryotic translation initiation factor 4E binding protein 2 2 2
MIRT455860 TMEM254 transmembrane protein 254 2 2
MIRT455919 RAPGEF1 Rap guanine nucleotide exchange factor 1 2 2
MIRT455946 CYP4A22 cytochrome P450 family 4 subfamily A member 22 2 2
MIRT456935 LRP10 LDL receptor related protein 10 2 2
MIRT457223 AP3D1 adaptor related protein complex 3 delta 1 subunit 2 2
MIRT457431 NOL10 nucleolar protein 10 2 2
MIRT457470 SLC35F6 solute carrier family 35 member F6 2 2
MIRT457907 ZNF212 zinc finger protein 212 2 2
MIRT458046 TSEN54 tRNA splicing endonuclease subunit 54 2 2
MIRT458073 RNLS renalase, FAD dependent amine oxidase 2 2
MIRT458234 NXPH3 neurexophilin 3 2 2
MIRT458307 TNFAIP8L3 TNF alpha induced protein 8 like 3 2 2
MIRT458378 ITM2C integral membrane protein 2C 2 2
MIRT458967 ZNF436 zinc finger protein 436 2 2
MIRT459099 CYP4A11 cytochrome P450 family 4 subfamily A member 11 2 2
MIRT459446 TMEM37 transmembrane protein 37 2 2
MIRT459671 VPS37C VPS37C, ESCRT-I subunit 2 2
MIRT460727 ASXL3 additional sex combs like 3, transcriptional regulator 2 2
MIRT460744 SRP14 signal recognition particle 14 2 2
MIRT461531 C14orf1 ergosterol biosynthesis 28 homolog 2 2
MIRT461752 DDX11 DEAD/H-box helicase 11 2 2
MIRT461837 F2RL3 F2R like thrombin or trypsin receptor 3 2 2
MIRT462019 RIF1 replication timing regulatory factor 1 2 2
MIRT462631 PHF5A PHD finger protein 5A 2 2
MIRT462772 ZNF8 zinc finger protein 8 2 2
MIRT463032 ZNF689 zinc finger protein 689 2 2
MIRT463886 WNT7B Wnt family member 7B 2 2
MIRT463995 WDTC1 WD and tetratricopeptide repeats 1 2 2
MIRT464371 URM1 ubiquitin related modifier 1 2 2
MIRT465342 TPM3 tropomyosin 3 2 4
MIRT465515 PRICKLE4 prickle planar cell polarity protein 4 2 2
MIRT465602 TNRC6A trinucleotide repeat containing 6A 2 2
MIRT465697 TNPO2 transportin 2 2 10
MIRT466988 SSRP1 structure specific recognition protein 1 2 4
MIRT467630 SLC7A5 solute carrier family 7 member 5 2 2
MIRT468132 SH3PXD2A SH3 and PX domains 2A 2 2
MIRT468322 SF3B3 splicing factor 3b subunit 3 2 2
MIRT468502 SESN2 sestrin 2 2 2
MIRT468881 RREB1 ras responsive element binding protein 1 2 2
MIRT469322 RGP1 RGP1 homolog, RAB6A GEF complex partner 1 2 2
MIRT469562 RARA retinoic acid receptor alpha 2 2
MIRT469898 PTRF caveolae associated protein 1 2 2
MIRT470045 PTGFRN prostaglandin F2 receptor inhibitor 2 2
MIRT470068 PTGES2 prostaglandin E synthase 2 2 2
MIRT470238 PRRC2A proline rich coiled-coil 2A 2 2
MIRT470390 PPP1R16B protein phosphatase 1 regulatory subunit 16B 2 2
MIRT470500 PPP1R11 protein phosphatase 1 regulatory inhibitor subunit 11 2 2
MIRT470689 POLR2D RNA polymerase II subunit D 2 2
MIRT470704 POGK pogo transposable element derived with KRAB domain 2 2
MIRT471083 PIK3C2B phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta 2 2
MIRT472482 NACC2 NACC family member 2 2 2
MIRT473583 MAT2A methionine adenosyltransferase 2A 2 2
MIRT474554 KLHDC3 kelch domain containing 3 2 2
MIRT474651 KLF13 Kruppel like factor 13 2 2
MIRT474843 KHSRP KH-type splicing regulatory protein 2 2
MIRT474934 KCTD15 potassium channel tetramerization domain containing 15 2 2
MIRT475573 HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 2 2
MIRT476045 GRSF1 G-rich RNA sequence binding factor 1 2 2
MIRT476080 GRB2 growth factor receptor bound protein 2 2 2
MIRT476440 GBA2 glucosylceramidase beta 2 2 2
MIRT476764 FOSL2 FOS like 2, AP-1 transcription factor subunit 2 2
MIRT478785 CRTC2 CREB regulated transcription coactivator 2 2 2
MIRT479287 CHAC1 ChaC glutathione specific gamma-glutamylcyclotransferase 1 2 2
MIRT479505 CDH6 cadherin 6 2 2
MIRT479732 CCND1 cyclin D1 2 6
MIRT480352 C5orf24 chromosome 5 open reading frame 24 2 2
MIRT480407 C19orf47 chromosome 19 open reading frame 47 2 2
MIRT480859 BHLHB9 basic helix-loop-helix family member b9 2 2
MIRT481445 ARRB2 arrestin beta 2 2 2
MIRT481732 APH1A aph-1 homolog A, gamma-secretase subunit 2 2
MIRT481824 AP2M1 adaptor related protein complex 2 mu 1 subunit 2 2
MIRT482566 ABHD2 abhydrolase domain containing 2 2 2
MIRT482607 ABHD14B abhydrolase domain containing 14B 2 2
MIRT483144 SYCE1L synaptonemal complex central element protein 1 like 2 2
MIRT483214 APOA1 apolipoprotein A1 2 6
MIRT483878 TGIF1 TGFB induced factor homeobox 1 2 2
MIRT483917 SPSB1 splA/ryanodine receptor domain and SOCS box containing 1 2 2
MIRT483939 LENG8 leukocyte receptor cluster member 8 2 4
MIRT484420 SNX19 sorting nexin 19 2 2
MIRT484489 SLC9A1 solute carrier family 9 member A1 2 2
MIRT484612 SIX3 SIX homeobox 3 2 6
MIRT484705 RNF11 ring finger protein 11 2 2
MIRT485107 SHISA6 shisa family member 6 2 2
MIRT485354 MYO1C myosin IC 2 4
MIRT485609 FOSL1 FOS like 1, AP-1 transcription factor subunit 2 4
MIRT487311 GLTSCR1 BRD4 interacting chromatin remodeling complex associated protein 2 2
MIRT487417 CACNB1 calcium voltage-gated channel auxiliary subunit beta 1 2 2
MIRT487695 CDK14 cyclin dependent kinase 14 2 2
MIRT487791 GPR20 G protein-coupled receptor 20 2 4
MIRT488042 PABPC1L2B poly(A) binding protein cytoplasmic 1 like 2B 2 2
MIRT488058 PABPC1L2A poly(A) binding protein cytoplasmic 1 like 2A 2 2
MIRT488237 DNLZ DNL-type zinc finger 2 4
MIRT488764 FXYD1 FXYD domain containing ion transport regulator 1 2 2
MIRT489401 TUBB2A tubulin beta 2A class IIa 2 2
MIRT489777 GRINA glutamate ionotropic receptor NMDA type subunit associated protein 1 2 2
MIRT490099 FN3K fructosamine 3 kinase 2 2
MIRT490290 ISL2 ISL LIM homeobox 2 2 2
MIRT490378 LHFPL3 LHFPL tetraspan subfamily member 3 2 2
MIRT491329 GFER growth factor, augmenter of liver regeneration 2 2
MIRT491435 MSX2 msh homeobox 2 2 2
MIRT491769 ZNF385A zinc finger protein 385A 2 2
MIRT491922 WNK2 WNK lysine deficient protein kinase 2 2 2
MIRT491983 UNK unkempt family zinc finger 2 2
MIRT492228 SLC48A1 solute carrier family 48 member 1 2 2
MIRT492404 SDK1 sidekick cell adhesion molecule 1 2 2
MIRT492767 PDGFB platelet derived growth factor subunit B 2 2
MIRT492966 NCS1 neuronal calcium sensor 1 2 2
MIRT493295 LLGL2 LLGL2, scribble cell polarity complex component 2 2
MIRT493650 HDLBP high density lipoprotein binding protein 2 2
MIRT493913 FAM127B retrotransposon Gag like 8A 2 4
MIRT495601 NKX2-5 NK2 homeobox 5 2 2
MIRT496875 AHCYL2 adenosylhomocysteinase like 2 2 2
MIRT498514 MYH14 myosin heavy chain 14 2 2
MIRT499178 RBPJL recombination signal binding protein for immunoglobulin kappa J region like 2 2
MIRT502143 KIF5B kinesin family member 5B 2 8
MIRT502692 CSNK1G1 casein kinase 1 gamma 1 2 4
MIRT508460 HOXB6 homeobox B6 2 4
MIRT510430 ZNF207 zinc finger protein 207 2 6
MIRT511837 GPATCH8 G-patch domain containing 8 2 4
MIRT512368 CPM carboxypeptidase M 2 2
MIRT512506 BTBD19 BTB domain containing 19 2 2
MIRT513065 ANKRD45 ankyrin repeat domain 45 2 2
MIRT513267 SCUBE1 signal peptide, CUB domain and EGF like domain containing 1 2 4
MIRT513575 EVX1 even-skipped homeobox 1 2 2
MIRT515051 EBNA1BP2 EBNA1 binding protein 2 2 2
MIRT515790 COL4A3BP collagen type IV alpha 3 binding protein 2 2
MIRT521657 PRKD3 protein kinase D3 2 2
MIRT522679 LUZP1 leucine zipper protein 1 2 6
MIRT528845 RAB32 RAB32, member RAS oncogene family 2 2
MIRT533569 TOR1AIP1 torsin 1A interacting protein 1 2 2
MIRT543738 DHCR7 7-dehydrocholesterol reductase 2 2
MIRT544295 TSPYL1 TSPY like 1 2 2
MIRT544857 MYH2 myosin heavy chain 2 2 4
MIRT557323 HIATL1 major facilitator superfamily domain containing 14B 2 4
MIRT560522 TMEM98 transmembrane protein 98 2 2
MIRT561565 SLC6A9 solute carrier family 6 member 9 2 2
MIRT562374 ERI2 ERI1 exoribonuclease family member 2 2 2
MIRT565780 SEMA6D semaphorin 6D 2 2
MIRT569548 UNC119B unc-119 lipid binding chaperone B 2 2
MIRT569944 PRRT2 proline rich transmembrane protein 2 2 2
MIRT570016 COL1A2 collagen type I alpha 2 chain 2 2
MIRT572163 CRK CRK proto-oncogene, adaptor protein 2 2
MIRT572322 HSPB6 heat shock protein family B (small) member 6 2 2
MIRT573495 IQSEC3 IQ motif and Sec7 domain 3 2 2
MIRT574139 MARVELD1 MARVEL domain containing 1 2 2
MIRT609449 CCDC149 coiled-coil domain containing 149 2 2
MIRT610619 ARHGAP18 Rho GTPase activating protein 18 2 2
MIRT623355 LZIC leucine zipper and CTNNBIP1 domain containing 2 2
MIRT629854 ACOX1 acyl-CoA oxidase 1 2 2
MIRT630516 CDC73 cell division cycle 73 2 2
MIRT632535 PSMB2 proteasome subunit beta 2 2 2
MIRT633975 SLC35E2 solute carrier family 35 member E2 2 2
MIRT636408 MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase 2 2
MIRT641722 LTBR lymphotoxin beta receptor 2 2
MIRT642661 RGS6 regulator of G protein signaling 6 2 2
MIRT649649 MAST3 microtubule associated serine/threonine kinase 3 2 2
MIRT650367 MOCS3 molybdenum cofactor synthesis 3 2 2
MIRT651355 ZBTB40 zinc finger and BTB domain containing 40 2 2
MIRT664840 HUS1 HUS1 checkpoint clamp component 2 2
MIRT667322 MYH9 myosin heavy chain 9 2 2
MIRT670680 SUGT1 SGT1 homolog, MIS12 kinetochore complex assembly cochaperone 2 2
MIRT674922 TRPM6 transient receptor potential cation channel subfamily M member 6 2 2
MIRT675919 CYP51A1 cytochrome P450 family 51 subfamily A member 1 2 2
MIRT676493 GJD3 gap junction protein delta 3 2 2
MIRT680162 ZDHHC20 zinc finger DHHC-type containing 20 2 2
MIRT688008 GSN gelsolin 2 2
MIRT688997 ATP6AP1 ATPase H+ transporting accessory protein 1 2 2
MIRT700337 RAB4A RAB4A, member RAS oncogene family 2 2
MIRT701344 NR4A3 nuclear receptor subfamily 4 group A member 3 2 2
MIRT703519 FKBP15 FK506 binding protein 15 2 2
MIRT703901 EPT1 selenoprotein I 2 2
MIRT705565 ARHGEF18 Rho/Rac guanine nucleotide exchange factor 18 2 2
MIRT709709 DNAJC11 DnaJ heat shock protein family (Hsp40) member C11 2 2
MIRT713108 TMBIM4 transmembrane BAX inhibitor motif containing 4 2 2
MIRT718426 ZNF85 zinc finger protein 85 2 2
MIRT719236 CYSLTR2 cysteinyl leukotriene receptor 2 2 2
MIRT719326 STAC SH3 and cysteine rich domain 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-4747 Paclitaxel 36314 NSC125973 approved resistant cell line (A2780)
hsa-miR-4747-5p Temozolomide 5394 NSC362856 approved sensitive cell line (U251)
hsa-miR-4747-5p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-4747-5p Gemcitabine 60750 NSC613327 approved sensitive cell line (PANC-1) (1500 ng/ml)

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