miRTarBase - #MIRT455142


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pre-miRNA Information
pre-miRNA hsa-mir-4270   
Genomic Coordinates chr3: 15496239 - 15496308
Description Homo sapiens miR-4270 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-4270
Sequence 11| UCAGGGAGUCAGGGGAGGGC |30
Evidence Experimental
Experiments SOLiD
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs991570490 2 dbSNP
rs1417709982 10 dbSNP
rs960511282 12 dbSNP
rs928808979 14 dbSNP
rs1372156971 15 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol TBC1D25   
Synonyms MG81, OATL1
Description TBC1 domain family member 25
Transcript NM_002536   
Expression
Putative miRNA Targets on TBC1D25
3'UTR of TBC1D25
(miRNA target sites are highlighted)		 
>TBC1D25|NM_002536|3'UTR
   1 TCAGGCTTTCTCAAGCCCTCCATCGGCCCCACCAGATCTCCATTCTTTGCCATGAGGGCCAACACATGAGACCCCACCTC
  81 CCTCCCTGCCTGCCAGCCCTAGACTTGTTGGAGCATAGAGCCCTTCCTCCCCAGGCCTAAGTATGTGGAGCTCTGCTTTG
 161 GCACTGCCCCGCAGAGGCCACGCCTATTTATTCTGTTTCTGTTGTTTTGTTTTTAACAACTATACTTTGCACACATGAAG
 241 GTCACTGTGGTTTGTGTGTTTCTCTGCCTCCTCCCTGGGTTTTGCTGTAGATGGAGTCCTCAGGGGCCCTTTACCTGATG
 321 GAGGGGAAATACTTCACTTGGTGGAGAGAGGCTCCAGCTTCCCCCTTGTGATGGGGAGAGTGGATGCTGACAATCAGTTC
 401 CCAAAGGTGAGCCCAGGTGGAGCACTGCTTGAGGAAGGCCTGAGTCTGTTTTTTTGGTACATCCATCGGCCTGTAAGGGT
 481 CTGTATTATGGCTGTGAATATATGTTTTCAGGACAGCCCCCTGGATGAGAGATAAGAGAGTTCCTGGCTCAAAAAAGGAC
 561 AAGATTCTTTACTGAGATTGGGAAGTATGGGCTACTTAGAAACGTTGGAGCAGCCACCCCTGGCATTCCACATGTCACCA
 641 TTTCTAGGATCTTGGCCTCTCTGTGAGGTTTATGCACCAATGCTGGCAGCCCTGGGCAGGGGCCTCGGCCTCCTTTTTGT
 721 TTTCCACTTCAGACAGGTACCGTGCAGATGTTAACAAGGTTTGAGCGAGGTGCATCTCACACAAGTGTGAAAGCCCAATC
 801 ATCACATTGTTGAATTACAAAAGGATCTAGGGCTCCTATTCTTGTCACTTGCTTTGGAGCCAGTTTGAAAGACTGGCCTA
 881 GCCCATGCCTAGCGGCCCTAAACTGGGATTCCAGCTCACAGCACCTGTCTTAACCATTTCAGCAGTAGAAACCACTTATT
 961 TACCTTCTCCATCTCACTAATATGGACAAACAACAAGCACTGATAAAACGCAGGCCCTAATAGAATTCACTTCGTTATTT
1041 GGAGGATAATGATCAAAAAAAGGTCCTTTTTCCCACTGACATGCTCAGAGGGTGGGATTCTCTCACAGGCCAGGTGCTGT
1121 CATCCACAAAGGATGGGTGAAATAACTGGGGTCCTCAGGTCACGGTCTAGCCACACCAGCTTCTCCCAAGTACTAACCAG
1201 GCTTGACCCTGCTTAGCTTCAGAGGTCAGACAAGATCTGGCATGTTCAGGATGGTATGGCTGTAGACCAGGCTGGGTTCT
1281 GGCCAGAGCTGTTGCACTAGGCAATGCTGCCAGAGATGAGGAGGCATCAGGGCAGTCATCCCTTCTGCTGTTTGCCCCAA
1361 GAATGCCATACAAACCTGGGGATGACCCTTAAAAGTCTCCCGTCACCCCCAGTATTGGGGGGAAGCTGACTATTCCTCAG
1441 ATGATAGCCCAGTCACTTGAAGAACAGGACAAGACTATTCTGTGTCTAGGGGGCTCAAGCACTGTGTGTGGGTCTAACGA
1521 ATGCATTTTGTGGAAATGGGCTCAGACTCCCCAAAGGGCCATCCAACCTATGGGAGTGTCTGGCCTTCTGAGGTCCTGAA
1601 ATGTCTCTTTTGTCAGTAAACAGCTAATACCCTCAAAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' cgGGAGGGGACUGAGGGACu 5'
            || | |||  ||||||| 
Target 5' gaCCCCACCTCCCTCCCTGc 3'
 70 - 89 158.00 -22.30
2 
miRNA  3' cggGAGGGGAC---UGAGGGACu 5'
             :|:|:|||    ||||||| 
Target 5' gtgTTTCTCTGCCTCCTCCCTGg 3'
 256 - 278 153.00 -22.90
3 
miRNA  3' cgggagGGGACU-GAGGGACu 5'
                :|:||: |||:||| 
Target 5' ctaggaTCTTGGCCTCTCTGt 3'
 644 - 664 134.00 -15.70
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs915773693 4 dbSNP
rs782146213 24 dbSNP
rs370192400 25 dbSNP
rs781880335 25 dbSNP
rs782419074 26 dbSNP
rs781922088 28 dbSNP
rs782636351 29 dbSNP
rs1242568600 36 dbSNP
rs782724956 52 dbSNP
rs781832514 53 dbSNP
rs1305994290 58 dbSNP
rs1396344115 67 dbSNP
rs1381109728 80 dbSNP
rs978937255 81 dbSNP
rs1300940063 83 dbSNP
rs782037606 93 dbSNP
rs1360585032 114 dbSNP
rs1299567101 121 dbSNP
rs924261765 128 dbSNP
rs1362915497 131 dbSNP
rs934327158 141 dbSNP
rs1165071863 156 dbSNP
rs1424724637 157 dbSNP
rs1416420409 165 dbSNP
rs1051472872 171 dbSNP
rs1485665036 172 dbSNP
rs1263992885 178 dbSNP
rs1218950799 179 dbSNP
rs912144137 182 dbSNP
rs1260319943 183 dbSNP
rs943624032 187 dbSNP
rs1245799110 200 dbSNP
rs1323225365 202 dbSNP
rs782051633 202 dbSNP
rs782078843 202 dbSNP
rs1039204191 203 dbSNP
rs1232594309 205 dbSNP
rs1341101641 205 dbSNP
rs782623459 207 dbSNP
rs11545129 210 dbSNP
rs1397537978 218 dbSNP
rs1383660471 226 dbSNP
rs899352434 233 dbSNP
rs1351971882 234 dbSNP
rs782329152 235 dbSNP
rs1475154021 253 dbSNP
rs1424905378 256 dbSNP
rs994885669 257 dbSNP
rs535402922 263 dbSNP
rs1426740400 269 dbSNP
rs1048286330 288 dbSNP
rs1261142762 293 dbSNP
rs886561799 298 dbSNP
rs1489625565 300 dbSNP
rs1263420514 303 dbSNP
rs1212896185 307 dbSNP
rs1003952234 315 dbSNP
rs1318365741 320 dbSNP
rs1279975283 324 dbSNP
rs184170244 325 dbSNP
rs1325296331 327 dbSNP
rs1035052229 337 dbSNP
rs1301432053 339 dbSNP
rs782091867 354 dbSNP
rs1388149540 364 dbSNP
rs1365100782 375 dbSNP
rs782273854 383 dbSNP
rs1012800081 394 dbSNP
rs1022729105 400 dbSNP
rs968524862 424 dbSNP
rs1401485288 428 dbSNP
rs1173380538 461 dbSNP
rs978498935 468 dbSNP
rs1372571132 469 dbSNP
rs782749778 474 dbSNP
rs1435110301 476 dbSNP
rs1031829685 479 dbSNP
rs955852991 481 dbSNP
rs1457995261 490 dbSNP
rs1259770101 522 dbSNP
rs987523433 525 dbSNP
rs911587215 530 dbSNP
rs1338743746 534 dbSNP
rs1256043428 558 dbSNP
rs1234721025 568 dbSNP
rs943571486 590 dbSNP
rs781864540 596 dbSNP
rs1328880417 605 dbSNP
rs1302152218 630 dbSNP
rs1447076335 632 dbSNP
rs547702492 633 dbSNP
rs1378091284 634 dbSNP
rs1333864535 635 dbSNP
rs56042532 645 dbSNP
rs920728913 668 dbSNP
rs1390132957 682 dbSNP
rs1396470563 685 dbSNP
rs1173700984 703 dbSNP
rs930800813 707 dbSNP
rs1393355769 708 dbSNP
rs1173190119 715 dbSNP
rs1440613035 721 dbSNP
rs1239772278 738 dbSNP
rs1047934364 743 dbSNP
rs1256721229 746 dbSNP
rs1437141280 746 dbSNP
rs1202111514 760 dbSNP
rs1345042276 763 dbSNP
rs886505454 764 dbSNP
rs1240415352 767 dbSNP
rs782708220 775 dbSNP
rs939480017 778 dbSNP
rs1056362862 781 dbSNP
rs1355454946 792 dbSNP
rs190218134 799 dbSNP
rs1237278916 802 dbSNP
rs782473878 803 dbSNP
rs1335367970 817 dbSNP
rs1022843610 820 dbSNP
rs1373698284 826 dbSNP
rs782189010 828 dbSNP
rs1420506190 847 dbSNP
rs1382453270 853 dbSNP
rs1157077418 855 dbSNP
rs577513805 862 dbSNP
rs1469377410 867 dbSNP
rs1368843560 872 dbSNP
rs1189516291 875 dbSNP
rs782624806 890 dbSNP
rs1484687219 894 dbSNP
rs181875299 895 dbSNP
rs1488995391 908 dbSNP
rs1281653980 913 dbSNP
rs1222859204 920 dbSNP
rs1350341334 938 dbSNP
rs781961411 942 dbSNP
rs1000433336 943 dbSNP
rs782533956 946 dbSNP
rs1292726104 949 dbSNP
rs1400640237 960 dbSNP
rs782110506 974 dbSNP
rs1031525654 983 dbSNP
rs782773935 998 dbSNP
rs1400402444 1010 dbSNP
rs782024327 1011 dbSNP
rs1164822766 1014 dbSNP
rs1474170143 1018 dbSNP
rs1417010905 1025 dbSNP
rs1018596874 1034 dbSNP
rs964383916 1035 dbSNP
rs1239877684 1038 dbSNP
rs1214620930 1039 dbSNP
rs565812355 1051 dbSNP
rs1451892961 1064 dbSNP
rs782456893 1066 dbSNP
rs782291748 1067 dbSNP
rs1290998952 1069 dbSNP
rs1215996110 1072 dbSNP
rs1333176965 1082 dbSNP
rs1273030838 1087 dbSNP
rs1219797507 1106 dbSNP
rs974442546 1108 dbSNP
rs1364154290 1109 dbSNP
rs920847040 1118 dbSNP
rs1430236526 1143 dbSNP
rs868989199 1164 dbSNP
rs782165211 1165 dbSNP
rs1459637573 1178 dbSNP
rs1393467559 1197 dbSNP
rs1171234293 1213 dbSNP
rs984012424 1229 dbSNP
rs908049855 1230 dbSNP
rs1467176559 1239 dbSNP
rs1416771404 1249 dbSNP
rs1185472246 1253 dbSNP
rs1478140191 1254 dbSNP
rs1248045838 1268 dbSNP
rs782310960 1276 dbSNP
rs1191395847 1298 dbSNP
rs1467373563 1299 dbSNP
rs782584702 1301 dbSNP
rs1199815265 1306 dbSNP
rs1309824579 1310 dbSNP
rs1270940420 1313 dbSNP
rs1214005298 1318 dbSNP
rs1345839494 1321 dbSNP
rs1305819852 1323 dbSNP
rs1439006711 1329 dbSNP
rs1369963879 1345 dbSNP
rs1043614 1346 dbSNP
rs1331870221 1346 dbSNP
rs939409183 1350 dbSNP
rs782213599 1355 dbSNP
rs1352743149 1360 dbSNP
rs1169683905 1365 dbSNP
rs1414505324 1367 dbSNP
rs7891547 1379 dbSNP
rs1171349291 1381 dbSNP
rs1453490856 1383 dbSNP
rs895115448 1398 dbSNP
rs781806814 1402 dbSNP
rs781980831 1403 dbSNP
rs1231628176 1406 dbSNP
rs1043745685 1416 dbSNP
rs904418129 1427 dbSNP
rs1000143427 1433 dbSNP
rs1053333595 1443 dbSNP
rs1232369437 1449 dbSNP
rs1347484754 1473 dbSNP
rs782123610 1479 dbSNP
rs782746145 1481 dbSNP
rs782402004 1485 dbSNP
rs1370952591 1487 dbSNP
rs1297470844 1507 dbSNP
rs1448739122 1514 dbSNP
rs150290744 1519 dbSNP
rs1008619400 1537 dbSNP
rs1310587199 1538 dbSNP
rs1433689422 1540 dbSNP
rs1380475299 1558 dbSNP
rs1018699597 1571 dbSNP
rs1421180924 1574 dbSNP
rs1406261660 1578 dbSNP
rs964498797 1587 dbSNP
rs1177125791 1615 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions TZM-bl
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM1462574. RNA binding protein: AGO2. Condition:TZM-bl ami BaL ...

- Whisnant AW; Bogerd HP; Flores O; Ho P; et al., 2013, mBio.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' cgGGAGGGGACUGAGGGACu 5'
            || | |||  ||||||| 
Target 5' -aCCCCACCUCCCUCCCUG- 3'
 		1 - 18
Article - Whisnant AW; Bogerd HP; Flores O; Ho P; et al.
- mBio, 2013
UNLABELLED: The question of how HIV-1 interfaces with cellular microRNA (miRNA) biogenesis and effector mechanisms has been highly controversial. Here, we first used deep sequencing of small RNAs present in two different infected cell lines (TZM-bl and C8166) and two types of primary human cells (CD4(+) peripheral blood mononuclear cells [PBMCs] and macrophages) to unequivocally demonstrate that HIV-1 does not encode any viral miRNAs. Perhaps surprisingly, we also observed that infection of T cells by HIV-1 has only a modest effect on the expression of cellular miRNAs at early times after infection. Comprehensive analysis of miRNA binding to the HIV-1 genome using the photoactivatable ribonucleoside-induced cross-linking and immunoprecipitation (PAR-CLIP) technique revealed several binding sites for cellular miRNAs, a subset of which were shown to be capable of mediating miRNA-mediated repression of gene expression. However, the main finding from this analysis is that HIV-1 transcripts are largely refractory to miRNA binding, most probably due to extensive viral RNA secondary structure. Together, these data demonstrate that HIV-1 neither encodes viral miRNAs nor strongly influences cellular miRNA expression, at least early after infection, and imply that HIV-1 transcripts have evolved to avoid inhibition by preexisting cellular miRNAs by adopting extensive RNA secondary structures that occlude most potential miRNA binding sites. IMPORTANCE: MicroRNAs (miRNAs) are a ubiquitous class of small regulatory RNAs that serve as posttranscriptional regulators of gene expression. Previous work has suggested that HIV-1 might subvert the function of the cellular miRNA machinery by expressing viral miRNAs or by dramatically altering the level of cellular miRNA expression. Using very sensitive approaches, we now demonstrate that neither of these ideas is in fact correct. Moreover, HIV-1 transcripts appear to largely avoid regulation by cellular miRNAs by adopting an extensive RNA secondary structure that occludes the ability of cellular miRNAs to interact with viral mRNAs. Together, these data suggest that HIV-1, rather than seeking to control miRNA function in infected cells, has instead evolved a mechanism to become largely invisible to cellular miRNA effector mechanisms.
LinkOut: [PMID: 23592263]
CLIP-seq Support 1 for dataset GSM1462574
Method / RBP PAR-CLIP / AGO2
Cell line / Condition TZM-bl / TZM-bl ami BaL
Location of target site ENST00000376771.4 | 3UTR | ACCCCACCUCCCUCCCUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23592263 / GSE59944
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
146 hsa-miR-4270 Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT056076 PIP4K2A phosphatidylinositol-5-phosphate 4-kinase type 2 alpha 2 2
MIRT057833 SLC30A7 solute carrier family 30 member 7 2 2
MIRT109295 TXLNG taxilin gamma 2 2
MIRT117521 MIDN midnolin 2 2
MIRT183504 BTG2 BTG anti-proliferation factor 2 2 2
MIRT258346 HOXA11 homeobox A11 2 6
MIRT275743 TFDP1 transcription factor Dp-1 2 2
MIRT284426 CAPN15 calpain 15 2 2
MIRT386430 CCL22 C-C motif chemokine ligand 22 2 2
MIRT443374 PLXNA2 plexin A2 2 2
MIRT445251 SEMA5A semaphorin 5A 2 2
MIRT445767 CCND3 cyclin D3 2 2
MIRT447231 ABI2 abl interactor 2 2 2
MIRT451224 ZNF444 zinc finger protein 444 2 2
MIRT451433 TJP3 tight junction protein 3 2 4
MIRT451959 TMPRSS5 transmembrane protease, serine 5 2 2
MIRT452006 FKBP5 FK506 binding protein 5 2 2
MIRT452300 EIF5AL1 eukaryotic translation initiation factor 5A-like 1 2 2
MIRT452717 DTHD1 death domain containing 1 2 2
MIRT453361 ZNF3 zinc finger protein 3 2 2
MIRT453458 GLG1 golgi glycoprotein 1 2 2
MIRT453832 SAA1 serum amyloid A1 2 2
MIRT453928 COMMD5 COMM domain containing 5 2 4
MIRT454312 ZNF134 zinc finger protein 134 2 2
MIRT454493 SLC29A1 solute carrier family 29 member 1 (Augustine blood group) 2 2
MIRT454836 POLR2J3 RNA polymerase II subunit J3 2 2
MIRT455142 TBC1D25 TBC1 domain family member 25 2 2
MIRT455922 RAPGEF1 Rap guanine nucleotide exchange factor 1 2 2
MIRT456163 TTF2 transcription termination factor 2 2 2
MIRT456395 KLHL12 kelch like family member 12 2 2
MIRT456786 MTHFSD methenyltetrahydrofolate synthetase domain containing 2 2
MIRT457164 MXRA7 matrix remodeling associated 7 2 2
MIRT457190 ERC1 ELKS/RAB6-interacting/CAST family member 1 2 2
MIRT457415 RPL36 ribosomal protein L36 2 2
MIRT457630 UPK3BL uroplakin 3B like 1 2 2
MIRT458720 VPS39 VPS39, HOPS complex subunit 2 2
MIRT458745 CES2 carboxylesterase 2 2 2
MIRT459269 ADRBK1 G protein-coupled receptor kinase 2 2 2
MIRT459490 CCL11 C-C motif chemokine ligand 11 2 2
MIRT460319 SH3RF1 SH3 domain containing ring finger 1 2 2
MIRT461005 SYT7 synaptotagmin 7 2 2
MIRT461579 SCO1 SCO1, cytochrome c oxidase assembly protein 2 4
MIRT461820 SNAP23 synaptosome associated protein 23 2 2
MIRT463332 ZFHX3 zinc finger homeobox 3 2 2
MIRT463449 ZC3HAV1L zinc finger CCCH-type containing, antiviral 1 like 2 2
MIRT464272 VCL vinculin 2 2
MIRT464895 UBALD1 UBA like domain containing 1 2 2
MIRT465556 TOB2 transducer of ERBB2, 2 2 2
MIRT466360 THBS1 thrombospondin 1 2 2
MIRT466956 STAT3 signal transducer and activator of transcription 3 2 2
MIRT467321 SPATA2 spermatogenesis associated 2 2 2
MIRT467440 SND1 staphylococcal nuclease and tudor domain containing 1 2 2
MIRT467823 SLC29A2 solute carrier family 29 member 2 2 2
MIRT471173 PHB2 prohibitin 2 2 2
MIRT471397 PDPR pyruvate dehydrogenase phosphatase regulatory subunit 2 2
MIRT471754 OGT O-linked N-acetylglucosamine (GlcNAc) transferase 2 2
MIRT471846 NUFIP2 NUFIP2, FMR1 interacting protein 2 2 2
MIRT472020 NPTXR neuronal pentraxin receptor 2 2
MIRT472224 NGFR nerve growth factor receptor 2 2
MIRT472439 NBL1 neuroblastoma 1, DAN family BMP antagonist 2 2
MIRT472541 NACC1 nucleus accumbens associated 1 2 2
MIRT473195 MINOS1-NBL1 MINOS1-NBL1 readthrough 2 2
MIRT473211 MINK1 misshapen like kinase 1 2 2
MIRT473668 MARCKSL1 MARCKS like 1 2 2
MIRT474852 KHSRP KH-type splicing regulatory protein 2 2
MIRT474939 KCTD15 potassium channel tetramerization domain containing 15 2 2
MIRT477330 EPHA2 EPH receptor A2 2 2
MIRT477395 ENTPD7 ectonucleoside triphosphate diphosphohydrolase 7 2 2
MIRT477466 ELMSAN1 ELM2 and Myb/SANT domain containing 1 2 2
MIRT477974 DPM2 dolichyl-phosphate mannosyltransferase subunit 2, regulatory 2 2
MIRT478331 DDN dendrin 2 2
MIRT479481 CDK2 cyclin dependent kinase 2 2 2
MIRT481212 ATXN7L3B ataxin 7 like 3B 2 2
MIRT481263 ATXN7L3 ataxin 7 like 3 2 2
MIRT481409 ASXL1 additional sex combs like 1, transcriptional regulator 2 2
MIRT482051 AMD1 adenosylmethionine decarboxylase 1 2 2
MIRT482396 AEN apoptosis enhancing nuclease 2 2
MIRT483160 PCSK2 proprotein convertase subtilisin/kexin type 2 2 7
MIRT483370 CYP4A22 cytochrome P450 family 4 subfamily A member 22 2 2
MIRT483520 QRSL1 glutaminyl-tRNA synthase (glutamine-hydrolyzing)-like 1 2 4
MIRT484059 CYP4A11 cytochrome P450 family 4 subfamily A member 11 2 2
MIRT487075 CLASP1 cytoplasmic linker associated protein 1 2 4
MIRT487421 CACNB1 calcium voltage-gated channel auxiliary subunit beta 1 2 2
MIRT488359 PAX2 paired box 2 2 2
MIRT488592 ST7L suppression of tumorigenicity 7 like 2 2
MIRT489556 SOX11 SRY-box 11 2 4
MIRT489804 KRT80 keratin 80 2 4
MIRT489865 ATP2A3 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3 2 2
MIRT490014 KIFC2 kinesin family member C2 2 2
MIRT490036 PCSK4 proprotein convertase subtilisin/kexin type 4 2 2
MIRT491070 ACVR1B activin A receptor type 1B 2 2
MIRT494016 DUSP9 dual specificity phosphatase 9 2 2
MIRT494816 AKAP11 A-kinase anchoring protein 11 2 2
MIRT495991 LTBP2 latent transforming growth factor beta binding protein 2 2 2
MIRT496272 SLC2A13 solute carrier family 2 member 13 2 2
MIRT500454 ZFP36L1 ZFP36 ring finger protein like 1 2 2
MIRT507989 BCL2L13 BCL2 like 13 2 4
MIRT509713 ANKRD23 ankyrin repeat domain 23 2 2
MIRT527984 TSLP thymic stromal lymphopoietin 2 2
MIRT530448 SULT1B1 sulfotransferase family 1B member 1 2 2
MIRT531235 FANCC Fanconi anemia complementation group C 2 2
MIRT534590 RPL28 ribosomal protein L28 2 2
MIRT535990 MED28 mediator complex subunit 28 2 4
MIRT537280 GABRA5 gamma-aminobutyric acid type A receptor alpha5 subunit 2 2
MIRT539924 DUSP28 dual specificity phosphatase 28 2 2
MIRT554711 RNF146 ring finger protein 146 2 2
MIRT558962 CAMSAP2 calmodulin regulated spectrin associated protein family member 2 2 2
MIRT568497 ARHGDIA Rho GDP dissociation inhibitor alpha 2 2
MIRT568875 LY6H lymphocyte antigen 6 family member H 2 2
MIRT568987 CACNA1C calcium voltage-gated channel subunit alpha1 C 2 2
MIRT569990 TMEM184A transmembrane protein 184A 2 2
MIRT570485 THRA thyroid hormone receptor, alpha 2 2
MIRT572826 MYO1C myosin IC 2 2
MIRT608199 ERBB2 erb-b2 receptor tyrosine kinase 2 2 2
MIRT613220 CCDC85C coiled-coil domain containing 85C 2 4
MIRT629782 PTDSS2 phosphatidylserine synthase 2 2 2
MIRT635332 RASSF4 Ras association domain family member 4 2 2
MIRT653632 SLC30A3 solute carrier family 30 member 3 2 2
MIRT664572 GUF1 GUF1 homolog, GTPase 2 2
MIRT667855 IPCEF1 interaction protein for cytohesin exchange factors 1 2 2
MIRT668820 CYLD CYLD lysine 63 deubiquitinase 2 2
MIRT671274 ETFDH electron transfer flavoprotein dehydrogenase 2 2
MIRT681448 CIITA class II major histocompatibility complex transactivator 2 2
MIRT684817 BRIX1 BRX1, biogenesis of ribosomes 2 2
MIRT685861 ANGEL1 angel homolog 1 2 2
MIRT688812 CAPZB capping actin protein of muscle Z-line beta subunit 2 2
MIRT691198 NIF3L1 NGG1 interacting factor 3 like 1 2 2
MIRT696947 CERK ceramide kinase 2 2
MIRT699741 SERBP1 SERPINE1 mRNA binding protein 1 2 2
MIRT701259 NUP35 nucleoporin 35 2 2
MIRT701935 MLLT1 MLLT1, super elongation complex subunit 2 2
MIRT703332 GDPD5 glycerophosphodiester phosphodiesterase domain containing 5 2 2
MIRT705519 ARL6IP1 ADP ribosylation factor like GTPase 6 interacting protein 1 2 2
MIRT706065 PKD1 polycystin 1, transient receptor potential channel interacting 2 2
MIRT713238 SV2B synaptic vesicle glycoprotein 2B 2 2
MIRT714670 CHRNE cholinergic receptor nicotinic epsilon subunit 2 2
MIRT715001 TSPAN11 tetraspanin 11 2 2
MIRT715356 VCAM1 vascular cell adhesion molecule 1 2 2
MIRT715971 FADS3 fatty acid desaturase 3 2 2
MIRT719585 FNBP4 formin binding protein 4 2 2
MIRT719667 DMRT2 doublesex and mab-3 related transcription factor 2 2 2
MIRT723360 ASCL2 achaete-scute family bHLH transcription factor 2 2 2
MIRT734985 GADD45A growth arrest and DNA damage inducible alpha 2 0
MIRT735022 MMP19 matrix metallopeptidase 19 3 0
MIRT737359 SATB2 SATB homeobox 2 3 0
MIRT756223 MCM3 minichromosome maintenance complex component 3 3 1
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-4 Dexamethasone approved 5743 Microarray primary rat thymocytes 20847043 2010 up-regulated
miR-4270 Ginsenoside Rh2 NULL 119307 Microarray NSCLC cell line A549 23152132 2013 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-4270 Platinum 23939 sensitive High Ovarian Cancer tissue
hsa-miR-4270 Fulvestrant 17756771 NSC719276 approved sensitive High Breast Cancer cell line (MCF-7)
hsa-miR-4270 Cisplatin 5460033 NSC119875 approved resistant High Hypopharyngeal Cancer cell line (FaDu)
hsa-mir-4270 Cisplatin 5460033 NSC119875 approved resistant cell line (BxPC3)
hsa-miR-4270 Cisplatin 5460033 NSC119875 approved resistant cell line (CAL-27) (cytosolic RNA)
hsa-miR-4270 Cisplatin 5460033 NSC119875 approved sensitive cell line (CAL-27) (total RNA)
hsa-miR-4270 Cisplatin 5460033 NSC119875 approved resistant cell line (CP20)
hsa-miR-4270 Cisplatin 5460033 NSC119875 approved resistant cell line (CIS)
hsa-miR-4270 Osimertinib 71496458 NSC779217 approved resistant cell line (H1975)
hsa-miR-4270 Gemcitabine 60750 NSC613327 approved resistant cell line (MDA-231)
hsa-miR-4270 Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-4270 Vemurafenib 42611257 NSC761431 approved sensitive cell line (LM16)
hsa-miR-4270 Gemcitabine 60750 NSC613327 approved sensitive cell line (PANC-1) (1500 ng/ml)
hsa-miR-4270 Gemcitabine 60750 NSC613327 approved sensitive cell line (PANC-1) (100 ng/ml)
hsa-miR-4270 Gemcitabine 60750 NSC613327 approved resistant cell line (Panc1-GR4)

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