miRTarBase - #MIRT455212


—
pre-miRNA Information
pre-miRNA hsa-mir-4481   
Genomic Coordinates chr10: 12653138 - 12653197
Description Homo sapiens miR-4481 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-4481
Sequence 1| GGAGUGGGCUGGUGGUU |17
Evidence Experimental
Experiments Illumina
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1299710636 5 dbSNP
rs1433739601 12 dbSNP
rs1266754238 14 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol GNL1   
Synonyms HSR1
Description G protein nucleolar 1 (putative)
Transcript NM_005275   
Expression
Putative miRNA Targets on GNL1
3'UTR of GNL1
(miRNA target sites are highlighted)		 
>GNL1|NM_005275|3'UTR
   1 GTTCCTCGCCCAGCGCCATCTTCCCTCCCAGTATCTTTGCTTTTGGACTGACCTGGGGGTATCTCCCCTCTGCCACCCCA
  81 ATTGTGAATAAAGATTGTTTGCTTTGTAGCCCCTTCCCCAGATGAACTGAGGTGAGAGCGGCTGTTCCAGGCTAACAGCT
 161 GTGGGAGGCTTCTCTCCTCTTCTCCCTTCTTTTTTCATGCATTCTCTTTGCAAGGGAAAGTTCTCTTAGGAGTTTAGTAG
 241 GTTCTCAGTCTCTGAAACCTGCTTCCTCTACCCATTCTCCCACTCTGCACCTTAGGAATCCCGTTATCTACATGGGGAGG
 321 GGAGGTCTAAATCCAGCTCCCTTTTGGAGTTTGTGCCATTCTCCGATTTGAGCAGCAGCCCTGTGTGCCCCCTGCCGCCA
 401 GACCTGCTCATTCCAGGAGCTTCTGGGAGAAGGAACAGTAAGAGAGGAACTGTGTCCCAAGCTGATGTCTCTTAATGAGA
 481 TTTTTACAGGAATTGTTCAAATTCAGCAAATATTTATTGAGGGTCTATTGTGTGTCTTGACCTGTGCTGAGCACCAAGCA
 561 TATAAGGATGTACCACCAGAGCCTGACCTAAATTTGAAGCCTGGCCATGATCAAAACCCCACCTTCAGGCACCCAAGTTT
 641 TTGGATTAAGAAGGGTGAATGATGTTCTCCAAATCCTGGGGGCTCATGCAGTATAATTCTAGGACTTCATGTTGATACAA
 721 ATTTTTAGTTAAGGCAAAACGCTTGTGAAAATGTTGATTAAATGTGTACGAGTAGTTTTAATTACTGGTGAACAACTAGC
 801 GTGCACATTTATGATTTGAGCAGAACAGCCCTTTAAGTACAGTGTTAAGTTTCATTGTTTAAAAGCTTGGCAGCTACGAG
 881 TATTTGAGGTACATAGGGGCGGGCACAGAACCAGCCTCCTGAATTCCATTTACTCTGGTTTGGGGGTGGAACAAAGATGA
 961 TCCAGTGCAGGGTCTGAGCTAGAACCTAGCAGGTGGCCAGAACCATTTTAGGGTTTCACCTCAGCATTTCGGCAGAAATC
1041 AGCTCTCTCGTGAGTCAGGGCACCTTAGGCTTTGCTGTATATCCCTTTGTTAAGCCAGCAGCTAGACTCCTAGATTGAAT
1121 TCTTTTAGAAATGGGAGAATGAGCTTTTTTATTGACTGCCAGTGTTGTCTGTATTGGATGATAGCAAAAAGTGTAGTTGG
1201 ACAGGTTGCCCACTAGATGGAGTGAGAAGTACCAGACTCCTTTTTTCTCTAAAGCAGATCCTTTCAGGATCTGAGTCACT
1281 GGGCAGTTTCTCTAATGCGAGCAGACAGACCCTGTTAACCAAGGAGCAAAGGAAAGTATATTTAAAGAGGCTAAGGTGTT
1361 TGGCCACATATTGCTTTAGGTTCATCTCCATTGGTCTCAGTGTGGACATAACTCCTGGAATTCACTCCAGTGCAAAGTTT
1441 AAATAATACCAGCATGAGAATGTACTTGAAGGTTTCCCAAAATGTGCTAGACAAGAAAGAGAAAAGGTCCCAGCTGAGAG
1521 AAAAATCCACCTGTCTCCCATCTGGGGCTCTTTGGCCTCACTGATAGAAAAGGAAAAGGGGCCCAAGCTAAGCTTACTTT
1601 GAGGGTTCATGATGTTCAGAGATGCTCAGGGGACTTCTCCGCTGCAGGAGGTGGGGTGAGGACATTGGATTCATTTCCTC
1681 AAAATATGGAGAGAAAGGAGAAAAATCAGAATTCTATTTGTACCTCTGCTTCCTGTGCTGTTTATCTTTGCTTGTCTTTA
1761 TCTTTTTCCACCTCAGGGGTTTCATCAGGGGTATTTGGGAGAGTCTAGGGGTGGGGATGAAGAATTGACTGGGAGCTGAG
1841 GAGGGGGGATTTTTATGCTGAAGACCTGGCAGGAGGCAACTCCTGACACCCCCACAGGGTTAGACTGTAAAACCTCTTCC
1921 ATGACTTGCTGACTCTATAGGATAATAGCAACAGGAAAAGAACTGAGGGACGTGCAGATGAGGATGAATAGGGCCCCAAC
2001 ACCAGTGCCTGAGGCTGAGGTTAGAACTGACTACAAAGACACAGGAAACCAAGGGCCCAGTCTCCCCTCCACGCTGAAAT
2081 ACGCACCCTCTTGTCTGGGTCATGTCTACTATGTGAATACTTGACCATGGAGGTCTGGGGCTCTGGTGGCTTCCATAGCT
2161 GGCTAGTCTCTTGATGGAGAGAAATCAGGGCTTCTCTCATCCATGCTGGAATTTCATTTAGATGTCAACTTCCAAGTTTC
2241 CCTTTTTCCAGATGGGATTATAGTCCTGCTTCTGGAACAGGGTAGCTGTGTGTGGTCCAGGATAGTTCAATTATCTGGCC
2321 CTTTGTTCACTTCTTACAATCATTGATACAGTCAACAAAAATTGGTTAAAAACAATATATGCCAGACATATATCCCTGAG
2401 TTCTGGGACAATAACCAAAATTGAATAAGGCAATATCCTACTCTCAAGCAATAGAGGGTAGGAATAGAATAATAATAATA
2481 TAATACAATAGCTCTATAGCAGTATGTAAACTATAAAAGCATTATTTTACGTGTTTCTATTGAACTGTCATAACTAAATA
2561 AGATGGTTAGTACTATAATTATCCCAAGGATTCATTCACTCATAGAACATTTGTTGAGCAATTACTACCTGCCAGTCACT
2641 TCCAAGTGGTAAGTGAGATAGAAATGGTTCTTTGTGGCGCTCACAATTTATTGGAGAATGGAAACACAATTACAAAAAAA
2721 AAGTGTGATAAGTTCTGGGAGAAGGGTGGTACAGGATCCTGTGGGGTAGTGGTGGCTCCATATAGGAGGGACATTGGGAT
2801 ACTGATCAGGAAGGAGTGGGGGACAGGGCTAGAAGCTGCATTAGTATAAAGTTATGTCAGACTGCCAAAACAAAACAAAC
2881 ACAAAAAATCAGTAGTCTGTGGTAAAGAATTGCTATAGGAACAGCCAGTAGGGGCAGTTAAGCTGGTCTTGGTGAATCAG
2961 GGGAAGCGTCCTAGAGGAACAGATGTCCATGCTGAGGCCAAATGCTGGACAGGAGTTAGCCAGACAGGGAAATTGCATTC
3041 TGGGCAGAGGAGACAGCAAAGGTCAAGAAACATGACAACTTTGGAAGACTGTAACTTGTTCAGAGGCAGAGGGTGCAAAG
3121 GAGAAATGAGGAAAGGTGAAGCTGGAGAGGTGGGCTTGGTCCAGCTCTTGCTGGGCCTTTTCAGCCGTGTTAAAGATTTA
3201 GACTGTATCCAGAGGGATGTTGAACTTTAAGCCTAAGACTGAAAAGGTGAGAATTGTGCCTTAGATCACTATGGTTGCAG
3281 TGTGGAGACTGGTTTGGAAAGGGGAGAAATCAGAGGCTTTTACAGCCATCCCAGGGAGAGAGAATGAACACCAGAATTAG
3361 GGTAATGGAAGATGGAAAGAAGAGAAATCGTTTTATGGGTTGCTCAGGAGATAGAATTGACATGTCTTGGGATTGTTTTG
3441 CTGTGTAGGGGAGAGAGACAAGTCAAGAGTATACATCCTGTTTCTGACTTGGCAACTGGGTGGGTCATGGGTCTGTTTCC
3521 TGAGACAGTTGTCTACAGCCATACCACCGTAAGCGCCCTAAATCTCATCAGAGACAGTTTATGCAAATGGAGCTTGGGGA
3601 AAGAGAGGTCGTGGCTGGAGACAGAGATTTGGGCATCATCAACATATAGGTGTGGGGAGCAGAGAAGGCTGAGGAAGAAA
3681 GCAGGAAACATATAAAAAGGAGAGCAGGGAAAGGAGCCAGTGAGACAGGAAAAACCTAGTAACGTGGTGTGATGAAGCTA
3761 GGGGAGGAAGGAAGGAAGGAAGGGCGGCGTGGAACGCTGCTGATGGGTGGTGGCGGGGAAAATGAACGAGTATCCACCAG
3841 CAACGAGAGGGGCCTCCATGGTCTTGGTGGGAGCATTTCTTTGGAGAGGTGGAATCAGAAGCCCCAGATGTCAGAGGGTT
3921 AAGGAATAATTTGGAGGAAAAGCGTAAAGGCAGTGGAGGTGAGGAGAGAATTTTCAAAATGTTTGGCAGTGATTGCAATG
4001 AAAGAAAAAAATGGAGGGAGCAGAGTATATGCAGTTGAGGAACTTTTTTAGTTTGGAGTGTGTTAACACGATGTTAGGAA
4081 GAAGGATCAAGTGAAGGAGAAAGGTGAAAATGCTGGAAGGTGGGGCTTAGTGATGAAACAAACCTTGGGGACAGGTGGGC
4161 GTGGTACTGAGAGTCCCAGTGAGGGGAGTGCCCTCAGGCAGGCGCCGGTGGCTTCTGTCACAGGAGGGAACAGCGCTGAC
4241 ATTCAGCTGGTTCGCACTGATACGGCTCAACCAGTTTGTTAAAACATGTCTGTTCCAGTGTCAGTAATATACGAGTAACT
4321 GCAATATGCAGTAAAAATTATAAATTCTAATACAAACTCAGTTCAAGCTAATTAAGAGATCGCAACAGCCGTTGGTAAAT
4401 GGACTTCCCGCTGCATTTGAGAAGCTTTGCAGCGCCATCTGCCGGTGTCGTAGCATCACTGCAGGCTGAGAGGCTGCTTT
4481 GCGCCTTCATCTTGAAGCACTCTGAAATTGCCTGTTTAAATTACCTTGGAATCATGGAGTTGCTACTGCTTCTGAATAGT
4561 TTAGCTTCTACTTTGATTTTATTGTTAGTGCATTGTCGTTCTTGTGTCAGTAGCAAGTTTCAGTGTTTTAATATTTACAA
4641 ATACAAAAATTTTTAATAAAATATTAAAGCCAAACTTGAATGAAGAGACAACAAAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' uuGGUGGUCGGGUGAGg 5'
            |||::  ||||||| 
Target 5' acCCATTCTCCCACTCt 3'
 270 - 286 151.00 -17.30
2 
miRNA  3' uugGUGGUCGGGUGAGg 5'
             || :| ||:|||| 
Target 5' aggCAATATCCTACTCt 3'
 2428 - 2444 134.00 -11.30
3 
miRNA  3' uuGGUGGUC-GGGUGAGg 5'
            ||:|||| ||::||| 
Target 5' tgCCGCCAGACCTGCTCa 3'
 393 - 410 131.00 -21.60
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN20075462 8 COSMIC
COSN30608398 14 COSMIC
COSN20075770 46 COSMIC
COSN31576691 88 COSMIC
COSN20075771 121 COSMIC
COSN6318251 140 COSMIC
COSN4858749 181 COSMIC
COSN4955080 324 COSMIC
COSN21458977 374 COSMIC
COSN6318250 397 COSMIC
COSN6318249 432 COSMIC
COSN195739 469 COSMIC
COSN9780181 564 COSMIC
COSN5087117 891 COSMIC
COSN2159253 1751 COSMIC
COSN22557257 1855 COSMIC
COSN25792499 2361 COSMIC
COSN32193080 2593 COSMIC
COSN6318248 3090 COSMIC
COSN6318247 3091 COSMIC
COSN27178574 3293 COSMIC
COSN26718445 3729 COSMIC
COSN25246302 4044 COSMIC
rs2524222 2679 GWAS
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1233173340 1 dbSNP
rs1327027698 5 dbSNP
rs149410704 6 dbSNP
rs761754782 7 dbSNP
rs1340183742 8 dbSNP
rs541460028 9 dbSNP
rs765309767 11 dbSNP
rs1404103329 14 dbSNP
rs369241036 15 dbSNP
rs376727402 16 dbSNP
rs771050386 17 dbSNP
rs372563352 18 dbSNP
rs527679043 19 dbSNP
rs975422518 20 dbSNP
rs760616802 26 dbSNP
rs1266162935 29 dbSNP
rs772413268 32 dbSNP
rs1432525833 40 dbSNP
rs748408097 43 dbSNP
rs1254513586 44 dbSNP
rs35466453 45 dbSNP
rs779343545 48 dbSNP
rs754550591 49 dbSNP
rs1034042524 53 dbSNP
rs1364710022 59 dbSNP
rs1244620436 65 dbSNP
rs561804425 70 dbSNP
rs541933029 77 dbSNP
rs576201371 81 dbSNP
rs1224656644 84 dbSNP
rs1447936635 110 dbSNP
rs999360069 117 dbSNP
rs1445488497 124 dbSNP
rs906400030 134 dbSNP
rs1243986048 139 dbSNP
rs1024355221 140 dbSNP
rs556365144 141 dbSNP
rs1471146429 152 dbSNP
rs866566982 161 dbSNP
rs1336783239 165 dbSNP
rs1407067086 170 dbSNP
rs1386806246 179 dbSNP
rs1455449287 181 dbSNP
rs894764359 182 dbSNP
rs1406395699 184 dbSNP
rs1451231547 187 dbSNP
rs1331679220 192 dbSNP
rs1397619599 198 dbSNP
rs1056056484 204 dbSNP
rs1348909453 206 dbSNP
rs879753525 214 dbSNP
rs1263945541 217 dbSNP
rs1049112390 219 dbSNP
rs761060175 228 dbSNP
rs1038016581 238 dbSNP
rs1252821318 250 dbSNP
rs1439488814 252 dbSNP
rs765390375 254 dbSNP
rs1182354975 259 dbSNP
rs1232249344 267 dbSNP
rs930656020 271 dbSNP
rs1178365854 272 dbSNP
rs1429521756 276 dbSNP
rs1469016637 279 dbSNP
rs900743655 295 dbSNP
rs36066637 297 dbSNP
rs546163123 300 dbSNP
rs939789161 302 dbSNP
rs577506519 303 dbSNP
rs1443905605 310 dbSNP
rs1039730386 316 dbSNP
rs1410051427 319 dbSNP
rs908284663 323 dbSNP
rs1050916993 324 dbSNP
rs554173261 325 dbSNP
rs1205597326 334 dbSNP
rs1345103951 337 dbSNP
rs1231425753 352 dbSNP
rs912052906 355 dbSNP
rs977781321 361 dbSNP
rs1205663789 364 dbSNP
rs1272159321 365 dbSNP
rs945145561 373 dbSNP
rs534570010 380 dbSNP
rs541554425 381 dbSNP
rs989093182 383 dbSNP
rs925966789 384 dbSNP
rs181477222 396 dbSNP
rs1033598745 397 dbSNP
rs759021531 406 dbSNP
rs773883666 407 dbSNP
rs1166850183 410 dbSNP
rs555475626 414 dbSNP
rs1427168356 419 dbSNP
rs967485283 420 dbSNP
rs1296030268 441 dbSNP
rs1365269466 462 dbSNP
rs1004948688 485 dbSNP
rs1385468629 486 dbSNP
rs1024389018 495 dbSNP
rs886506860 498 dbSNP
rs1226747705 500 dbSNP
rs1295563773 507 dbSNP
rs1027771739 508 dbSNP
rs1224540117 512 dbSNP
rs994834750 513 dbSNP
rs1454066516 519 dbSNP
rs900502226 523 dbSNP
rs993036752 525 dbSNP
rs1039251607 527 dbSNP
rs1207871173 529 dbSNP
rs1297320445 531 dbSNP
rs1263369282 543 dbSNP
rs944963945 557 dbSNP
rs890604199 560 dbSNP
rs770390458 562 dbSNP
rs748963676 574 dbSNP
rs1164712339 599 dbSNP
rs1445932418 599 dbSNP
rs1385183360 600 dbSNP
rs995515711 605 dbSNP
rs1291042936 607 dbSNP
rs1385923313 609 dbSNP
rs777349808 610 dbSNP
rs1017039687 613 dbSNP
rs1385006021 620 dbSNP
rs1356114843 632 dbSNP
rs1315593218 633 dbSNP
rs535574480 637 dbSNP
rs1162392879 644 dbSNP
rs1242310397 652 dbSNP
rs1003872791 655 dbSNP
rs1423966240 676 dbSNP
rs1385732194 680 dbSNP
rs1185514320 683 dbSNP
rs188652811 685 dbSNP
rs1245832574 686 dbSNP
rs1462230732 697 dbSNP
rs1437828870 703 dbSNP
rs1249900264 718 dbSNP
rs886896736 754 dbSNP
rs1178052753 756 dbSNP
rs1481724440 758 dbSNP
rs769583245 759 dbSNP
rs1264089058 764 dbSNP
rs933707582 766 dbSNP
rs747971665 769 dbSNP
rs989229154 770 dbSNP
rs1453426000 797 dbSNP
rs937654844 800 dbSNP
rs926290312 801 dbSNP
rs1378329163 821 dbSNP
rs1294502169 823 dbSNP
rs549992303 826 dbSNP
rs982024554 828 dbSNP
rs935940851 850 dbSNP
rs1314678391 852 dbSNP
rs925879269 855 dbSNP
rs144115156 865 dbSNP
rs1265806696 873 dbSNP
rs767613538 877 dbSNP
rs142577772 878 dbSNP
rs1236451709 893 dbSNP
rs1482561739 905 dbSNP
rs547382223 906 dbSNP
rs754920746 908 dbSNP
rs750508257 913 dbSNP
rs779163316 920 dbSNP
rs1366115288 921 dbSNP
rs1470458326 928 dbSNP
rs958753931 934 dbSNP
rs527642816 935 dbSNP
rs563093957 936 dbSNP
rs1165463155 937 dbSNP
rs1357433247 944 dbSNP
rs994929638 946 dbSNP
rs115957008 949 dbSNP
rs973580880 956 dbSNP
rs1408961922 959 dbSNP
rs1400755344 967 dbSNP
rs1421134847 971 dbSNP
rs1346995103 972 dbSNP
rs558706490 973 dbSNP
rs1018039604 980 dbSNP
rs1277488285 998 dbSNP
rs964000771 1000 dbSNP
rs1206044058 1005 dbSNP
rs1252371039 1030 dbSNP
rs1265466879 1031 dbSNP
rs1015173311 1045 dbSNP
rs1008922348 1050 dbSNP
rs1271585994 1050 dbSNP
rs1190768721 1052 dbSNP
rs1005505375 1057 dbSNP
rs541897978 1058 dbSNP
rs1430343234 1059 dbSNP
rs1171274163 1060 dbSNP
rs1490634850 1061 dbSNP
rs1429096687 1094 dbSNP
rs1305953058 1110 dbSNP
rs890688833 1119 dbSNP
rs1405346975 1129 dbSNP
rs1175516938 1130 dbSNP
rs1029257368 1142 dbSNP
rs867439636 1143 dbSNP
rs531724788 1151 dbSNP
rs997910229 1161 dbSNP
rs1009689635 1162 dbSNP
rs1485810539 1164 dbSNP
rs893979222 1181 dbSNP
rs757361302 1190 dbSNP
rs899574623 1191 dbSNP
rs1039972794 1208 dbSNP
rs1221336511 1211 dbSNP
rs1245170396 1219 dbSNP
rs935843640 1222 dbSNP
rs1187172950 1223 dbSNP
rs1389705730 1227 dbSNP
rs867126619 1231 dbSNP
rs1447739829 1232 dbSNP
rs1166581117 1239 dbSNP
rs1387040355 1240 dbSNP
rs17195411 1246 dbSNP
rs1041639753 1247 dbSNP
rs574259959 1255 dbSNP
rs569537197 1258 dbSNP
rs1280899885 1260 dbSNP
rs1289088968 1261 dbSNP
rs1222513842 1263 dbSNP
rs1225572937 1264 dbSNP
rs1317727700 1277 dbSNP
rs945913771 1287 dbSNP
rs1228087472 1288 dbSNP
rs917271270 1297 dbSNP
rs1159041247 1298 dbSNP
rs546332443 1299 dbSNP
rs1247661402 1311 dbSNP
rs1380491947 1319 dbSNP
rs1185538566 1321 dbSNP
rs1244865129 1332 dbSNP
rs577375329 1336 dbSNP
rs12192673 1344 dbSNP
rs949112349 1347 dbSNP
rs927390429 1349 dbSNP
rs137981827 1353 dbSNP
rs982696267 1371 dbSNP
rs1176057544 1373 dbSNP
rs1338190327 1374 dbSNP
rs753088753 1380 dbSNP
rs1480875634 1388 dbSNP
rs767954195 1402 dbSNP
rs1448029684 1403 dbSNP
rs184302063 1408 dbSNP
rs1375912915 1412 dbSNP
rs1224713806 1427 dbSNP
rs1267703502 1430 dbSNP
rs983679903 1443 dbSNP
rs760533299 1444 dbSNP
rs1191902482 1449 dbSNP
rs1446950449 1450 dbSNP
rs954936201 1453 dbSNP
rs1262967669 1458 dbSNP
rs1205206182 1460 dbSNP
rs1486600138 1462 dbSNP
rs1029308380 1468 dbSNP
rs1186678070 1486 dbSNP
rs1260688570 1496 dbSNP
rs997794094 1502 dbSNP
rs1323763895 1503 dbSNP
rs964168540 1505 dbSNP
rs1284984745 1511 dbSNP
rs1224895737 1515 dbSNP
rs965137773 1526 dbSNP
rs1018022898 1531 dbSNP
rs1017717038 1539 dbSNP
rs1009305922 1546 dbSNP
rs1402216208 1565 dbSNP
rs1413425537 1578 dbSNP
rs1041914804 1586 dbSNP
rs1338083902 1590 dbSNP
rs954771480 1594 dbSNP
rs376126341 1605 dbSNP
rs1288177918 1611 dbSNP
rs1336130740 1626 dbSNP
rs1348852404 1629 dbSNP
rs1009784035 1632 dbSNP
rs181709781 1640 dbSNP
rs1053901661 1641 dbSNP
rs1198831713 1642 dbSNP
rs1276380343 1644 dbSNP
rs1439541424 1646 dbSNP
rs760124627 1649 dbSNP
rs1057186344 1656 dbSNP
rs1471491595 1657 dbSNP
rs1002401263 1660 dbSNP
rs189150033 1664 dbSNP
rs1170343491 1672 dbSNP
rs555986251 1676 dbSNP
rs1399237529 1682 dbSNP
rs1058318 1686 dbSNP
rs1196028731 1687 dbSNP
rs949029422 1695 dbSNP
rs1037798215 1696 dbSNP
rs1324402156 1706 dbSNP
rs570568642 1710 dbSNP
rs908213037 1714 dbSNP
rs145350687 1716 dbSNP
rs1461502639 1718 dbSNP
rs983566742 1733 dbSNP
rs1273849153 1735 dbSNP
rs1481924493 1740 dbSNP
rs931235046 1755 dbSNP
rs919864296 1756 dbSNP
rs975637650 1759 dbSNP
rs1267581635 1760 dbSNP
rs1264542208 1762 dbSNP
rs1193715275 1772 dbSNP
rs923517499 1777 dbSNP
rs760331513 1807 dbSNP
rs1168453849 1809 dbSNP
rs976429777 1811 dbSNP
rs963752337 1813 dbSNP
rs533862957 1817 dbSNP
rs1390272353 1820 dbSNP
rs910624137 1830 dbSNP
rs987576973 1831 dbSNP
rs141691030 1841 dbSNP
rs1434495398 1846 dbSNP
rs1393312605 1848 dbSNP
rs548218908 1864 dbSNP
rs1340023451 1878 dbSNP
rs1380441994 1882 dbSNP
rs1010063198 1883 dbSNP
rs1314485584 1894 dbSNP
rs1453388323 1900 dbSNP
rs988330430 1902 dbSNP
rs958266266 1920 dbSNP
rs531688854 1923 dbSNP
rs1032626273 1925 dbSNP
rs1385265612 1930 dbSNP
rs1002778126 1937 dbSNP
rs895772721 1937 dbSNP
rs1409593485 1958 dbSNP
rs1001418217 1971 dbSNP
rs184744165 1972 dbSNP
rs1160466879 1986 dbSNP
rs767613487 1991 dbSNP
rs905875809 2008 dbSNP
rs767237132 2014 dbSNP
rs1362933854 2020 dbSNP
rs368400154 2027 dbSNP
rs1313357490 2029 dbSNP
rs1169975056 2036 dbSNP
rs562960969 2038 dbSNP
rs539537080 2042 dbSNP
rs771250521 2044 dbSNP
rs747942276 2048 dbSNP
rs1329490945 2062 dbSNP
rs1207541211 2067 dbSNP
rs552406347 2072 dbSNP
rs886748873 2073 dbSNP
rs1046745120 2074 dbSNP
rs1182893975 2078 dbSNP
rs1444788247 2082 dbSNP
rs1256100851 2084 dbSNP
rs1422395627 2087 dbSNP
rs1184477066 2088 dbSNP
rs930993437 2092 dbSNP
rs898406627 2093 dbSNP
rs1456972420 2108 dbSNP
rs1157218470 2110 dbSNP
rs1408311765 2111 dbSNP
rs933487893 2112 dbSNP
rs1303316430 2116 dbSNP
rs1244432241 2120 dbSNP
rs1179288286 2133 dbSNP
rs1401456070 2141 dbSNP
rs1039662910 2142 dbSNP
rs923404669 2148 dbSNP
rs974976181 2149 dbSNP
rs781008049 2159 dbSNP
rs11753992 2171 dbSNP
rs1357206326 2172 dbSNP
rs987933227 2192 dbSNP
rs866024021 2194 dbSNP
rs1313391063 2210 dbSNP
rs12664853 2221 dbSNP
rs968529664 2224 dbSNP
rs914012911 2229 dbSNP
rs1361749451 2236 dbSNP
rs1255894330 2242 dbSNP
rs988090199 2251 dbSNP
rs150096747 2259 dbSNP
rs1020041790 2265 dbSNP
rs1252901364 2267 dbSNP
rs1033005769 2269 dbSNP
rs140682223 2271 dbSNP
rs768295614 2277 dbSNP
rs575249383 2279 dbSNP
rs1001476892 2280 dbSNP
rs561666804 2281 dbSNP
rs1164841683 2284 dbSNP
rs1309770060 2288 dbSNP
rs886843352 2297 dbSNP
rs1305838727 2303 dbSNP
rs375295651 2310 dbSNP
rs995167937 2322 dbSNP
rs1469332135 2326 dbSNP
rs1310955488 2329 dbSNP
rs898163514 2337 dbSNP
rs746986991 2339 dbSNP
rs1363958869 2341 dbSNP
rs942646949 2343 dbSNP
rs1489816751 2351 dbSNP
rs1006627282 2364 dbSNP
rs1248697122 2373 dbSNP
rs1267897012 2375 dbSNP
rs886564854 2384 dbSNP
rs1047808455 2390 dbSNP
rs780080776 2391 dbSNP
rs1490811090 2393 dbSNP
rs757414358 2400 dbSNP
rs933374973 2403 dbSNP
rs541802847 2411 dbSNP
rs151331682 2418 dbSNP
rs1050931173 2420 dbSNP
rs1166427721 2436 dbSNP
rs1351267040 2438 dbSNP
rs902034839 2441 dbSNP
rs1292573812 2442 dbSNP
rs1364943565 2443 dbSNP
rs1039156885 2465 dbSNP
rs945914304 2469 dbSNP
rs575378114 2473 dbSNP
rs1342015265 2481 dbSNP
rs1226668962 2486 dbSNP
rs1292387072 2488 dbSNP
rs1322693378 2490 dbSNP
rs1221185638 2494 dbSNP
rs556187737 2503 dbSNP
rs947042356 2527 dbSNP
rs1052510178 2530 dbSNP
rs778196129 2531 dbSNP
rs1448730292 2532 dbSNP
rs959752662 2533 dbSNP
rs1415773816 2557 dbSNP
rs539179426 2558 dbSNP
rs1163688881 2559 dbSNP
rs1391785956 2559 dbSNP
rs878872850 2562 dbSNP
rs1458381890 2571 dbSNP
rs1320575338 2582 dbSNP
rs761678922 2583 dbSNP
rs370794853 2588 dbSNP
rs1286455409 2599 dbSNP
rs1380410918 2601 dbSNP
rs1228075277 2605 dbSNP
rs1288027621 2633 dbSNP
rs1331422464 2634 dbSNP
rs192198923 2637 dbSNP
rs1267507546 2645 dbSNP
rs1399542691 2655 dbSNP
rs1213621050 2656 dbSNP
rs969647721 2659 dbSNP
rs752826760 2666 dbSNP
rs1016592573 2671 dbSNP
rs918191164 2677 dbSNP
rs1473023472 2678 dbSNP
rs2524222 2679 dbSNP
rs1415233391 2685 dbSNP
rs886451932 2689 dbSNP
rs1159440813 2698 dbSNP
rs1026247513 2709 dbSNP
rs997576750 2721 dbSNP
rs113284811 2723 dbSNP
rs1258234279 2723 dbSNP
rs567468387 2724 dbSNP
rs1447788994 2727 dbSNP
rs951564188 2730 dbSNP
rs1039236560 2732 dbSNP
rs1291755455 2749 dbSNP
rs1352563445 2751 dbSNP
rs1229310581 2755 dbSNP
rs1428387358 2758 dbSNP
rs959075476 2764 dbSNP
rs1025358247 2778 dbSNP
rs1478980305 2780 dbSNP
rs995262839 2782 dbSNP
rs1280683211 2791 dbSNP
rs1442877104 2792 dbSNP
rs962664401 2799 dbSNP
rs189551393 2813 dbSNP
rs575718153 2819 dbSNP
rs113837438 2827 dbSNP
rs569181399 2831 dbSNP
rs1483906659 2832 dbSNP
rs1182513763 2838 dbSNP
rs552619880 2847 dbSNP
rs146894001 2849 dbSNP
rs891033593 2851 dbSNP
rs766869077 2855 dbSNP
rs12525465 2857 dbSNP
rs1426497055 2860 dbSNP
rs1414331571 2876 dbSNP
rs1286405982 2878 dbSNP
rs1311583947 2880 dbSNP
rs1372850110 2880 dbSNP
rs376139717 2881 dbSNP
rs1052752774 2882 dbSNP
rs768340605 2884 dbSNP
rs938441297 2891 dbSNP
rs891635333 2895 dbSNP
rs1275443658 2897 dbSNP
rs1284355446 2914 dbSNP
rs1344396096 2920 dbSNP
rs1052439502 2929 dbSNP
rs1278075022 2936 dbSNP
rs979999298 2938 dbSNP
rs970299625 2942 dbSNP
rs936774467 2945 dbSNP
rs1270193338 2947 dbSNP
rs560729079 2952 dbSNP
rs534090136 2953 dbSNP
rs1435655775 2961 dbSNP
rs142544993 2968 dbSNP
rs1246849182 2970 dbSNP
rs147706805 2971 dbSNP
rs114983289 2980 dbSNP
rs950614508 2992 dbSNP
rs1172364795 3001 dbSNP
rs948082688 3005 dbSNP
rs1430830893 3013 dbSNP
rs1026298492 3028 dbSNP
rs1388813073 3034 dbSNP
rs772688631 3036 dbSNP
rs1330648502 3042 dbSNP
rs966137040 3054 dbSNP
rs1018106429 3063 dbSNP
rs1344163856 3064 dbSNP
rs992412454 3073 dbSNP
rs951492950 3078 dbSNP
rs1337195811 3086 dbSNP
rs1416028590 3090 dbSNP
rs777251552 3090 dbSNP
rs1377245376 3091 dbSNP
rs1417114616 3093 dbSNP
rs1450575188 3095 dbSNP
rs1185909827 3099 dbSNP
rs973795482 3100 dbSNP
rs1250462317 3109 dbSNP
rs776096292 3112 dbSNP
rs769281337 3117 dbSNP
rs551443063 3128 dbSNP
rs962474043 3131 dbSNP
rs1459749361 3135 dbSNP
rs1181783086 3151 dbSNP
rs184475417 3154 dbSNP
rs1390236312 3161 dbSNP
rs1263919567 3173 dbSNP
rs1459962647 3177 dbSNP
rs1006551535 3186 dbSNP
rs114230452 3187 dbSNP
rs1052804695 3195 dbSNP
rs141270127 3195 dbSNP
rs1272708589 3199 dbSNP
rs1246672035 3201 dbSNP
rs928282624 3214 dbSNP
rs780587952 3228 dbSNP
rs1299203522 3246 dbSNP
rs1211286424 3247 dbSNP
rs1449757863 3252 dbSNP
rs1269549505 3254 dbSNP
rs11369176 3257 dbSNP
rs948471759 3264 dbSNP
rs555929223 3271 dbSNP
rs1260222102 3272 dbSNP
rs891605625 3278 dbSNP
rs1054197321 3279 dbSNP
rs568896268 3280 dbSNP
rs1368129062 3281 dbSNP
rs1474309492 3291 dbSNP
rs903928080 3301 dbSNP
rs116841051 3306 dbSNP
rs948040293 3322 dbSNP
rs1288254487 3326 dbSNP
rs966023486 3327 dbSNP
rs896496399 3337 dbSNP
rs1056701561 3340 dbSNP
rs930230445 3345 dbSNP
rs1354581156 3347 dbSNP
rs1410490017 3360 dbSNP
rs1008074407 3361 dbSNP
rs968140968 3373 dbSNP
rs1237656364 3382 dbSNP
rs1391879274 3384 dbSNP
rs1484491734 3388 dbSNP
rs1161757803 3393 dbSNP
rs1201392894 3394 dbSNP
rs1257337649 3395 dbSNP
rs1484886249 3402 dbSNP
rs1184668762 3405 dbSNP
rs918866811 3419 dbSNP
rs974226490 3420 dbSNP
rs1412928973 3422 dbSNP
rs1022913287 3423 dbSNP
rs1444155006 3455 dbSNP
rs1156944019 3459 dbSNP
rs941560663 3463 dbSNP
rs1467584261 3464 dbSNP
rs1243807457 3468 dbSNP
rs910973437 3469 dbSNP
rs746711803 3470 dbSNP
rs1183863032 3478 dbSNP
rs985618660 3495 dbSNP
rs76003100 3506 dbSNP
rs955036593 3507 dbSNP
rs369223931 3509 dbSNP
rs1003764487 3519 dbSNP
rs1350676422 3531 dbSNP
rs1205603588 3533 dbSNP
rs140683678 3537 dbSNP
rs1344951225 3548 dbSNP
rs906879250 3555 dbSNP
rs988457084 3561 dbSNP
rs1234676182 3563 dbSNP
rs1044046421 3564 dbSNP
rs1346211900 3566 dbSNP
rs145548933 3567 dbSNP
rs376772038 3576 dbSNP
rs775632809 3586 dbSNP
rs1252832475 3587 dbSNP
rs1397450150 3590 dbSNP
rs1370668349 3592 dbSNP
rs1480393601 3600 dbSNP
rs1175701324 3608 dbSNP
rs887523571 3608 dbSNP
rs1032924058 3609 dbSNP
rs772118755 3610 dbSNP
rs1297412332 3618 dbSNP
rs1433823709 3623 dbSNP
rs1174227973 3628 dbSNP
rs905694122 3637 dbSNP
rs1432654584 3640 dbSNP
rs1170183323 3644 dbSNP
rs1370789951 3650 dbSNP
rs1442585609 3657 dbSNP
rs1441111776 3661 dbSNP
rs1296079726 3671 dbSNP
rs1048919399 3674 dbSNP
rs1386810232 3690 dbSNP
rs929142902 3695 dbSNP
rs1023685736 3702 dbSNP
rs1231084994 3705 dbSNP
rs192877168 3716 dbSNP
rs1307273694 3720 dbSNP
rs896465353 3731 dbSNP
rs1056460721 3743 dbSNP
rs539992370 3745 dbSNP
rs1193036329 3751 dbSNP
rs574307840 3755 dbSNP
rs929990114 3777 dbSNP
rs1166948382 3780 dbSNP
rs944615700 3784 dbSNP
rs975982208 3784 dbSNP
rs1420034968 3785 dbSNP
rs550668458 3789 dbSNP
rs1409131675 3795 dbSNP
rs897404566 3798 dbSNP
rs1457986635 3802 dbSNP
rs1039067665 3805 dbSNP
rs1178142383 3810 dbSNP
rs941501262 3814 dbSNP
rs911389585 3815 dbSNP
rs758796447 3825 dbSNP
rs1267187805 3828 dbSNP
rs1213136777 3831 dbSNP
rs1315137424 3835 dbSNP
rs933720895 3836 dbSNP
rs922371477 3837 dbSNP
rs1322495774 3844 dbSNP
rs988404467 3857 dbSNP
rs1271420985 3858 dbSNP
rs1466297830 3864 dbSNP
rs1210569897 3865 dbSNP
rs1242595612 3866 dbSNP
rs1474976303 3871 dbSNP
rs148543445 3871 dbSNP
rs1490644999 3888 dbSNP
rs1475371209 3903 dbSNP
rs1163746043 3909 dbSNP
rs1391716941 3910 dbSNP
rs1032889805 3917 dbSNP
rs1319593268 3921 dbSNP
rs1345066093 3932 dbSNP
rs956867258 3940 dbSNP
rs1246285707 3946 dbSNP
rs1035158875 3949 dbSNP
rs1003818499 3950 dbSNP
rs1291645246 3956 dbSNP
rs866434493 3958 dbSNP
rs1314771869 3960 dbSNP
rs145751426 3964 dbSNP
rs1228605211 3969 dbSNP
rs969904966 3984 dbSNP
rs1023083404 3993 dbSNP
rs1229035550 4004 dbSNP
rs1012578827 4008 dbSNP
rs887398919 4012 dbSNP
rs1352148002 4021 dbSNP
rs1048804056 4025 dbSNP
rs1485866244 4029 dbSNP
rs1023243740 4030 dbSNP
rs569222106 4035 dbSNP
rs1281102689 4036 dbSNP
rs1415161370 4042 dbSNP
rs1473300181 4043 dbSNP
rs1404286702 4051 dbSNP
rs1407900990 4055 dbSNP
rs1399535936 4060 dbSNP
rs1178851817 4064 dbSNP
rs1366060000 4070 dbSNP
rs929026519 4073 dbSNP
rs1311323400 4077 dbSNP
rs562309371 4086 dbSNP
rs1352502170 4087 dbSNP
rs1040164050 4119 dbSNP
rs1295375950 4126 dbSNP
rs1451636492 4141 dbSNP
rs1278962661 4142 dbSNP
rs1348617539 4143 dbSNP
rs1014106307 4145 dbSNP
rs756102273 4150 dbSNP
rs558723427 4152 dbSNP
rs944649114 4157 dbSNP
rs910461704 4160 dbSNP
rs149778382 4161 dbSNP
rs757419417 4167 dbSNP
rs1199089774 4175 dbSNP
rs1481059989 4181 dbSNP
rs915210948 4184 dbSNP
rs1182078876 4185 dbSNP
rs566808635 4186 dbSNP
rs1270017324 4192 dbSNP
rs988237068 4206 dbSNP
rs1203895785 4207 dbSNP
rs866615106 4211 dbSNP
rs1193466404 4215 dbSNP
rs897197349 4218 dbSNP
rs1396168200 4220 dbSNP
rs1434508964 4233 dbSNP
rs1484642051 4234 dbSNP
rs547128150 4239 dbSNP
rs1372644875 4253 dbSNP
rs956754614 4265 dbSNP
rs1328414539 4282 dbSNP
rs1334103889 4290 dbSNP
rs1035212933 4293 dbSNP
rs539418193 4296 dbSNP
rs187311511 4303 dbSNP
rs139676137 4304 dbSNP
rs1233301256 4305 dbSNP
rs781208035 4312 dbSNP
rs890065661 4315 dbSNP
rs1050324531 4320 dbSNP
rs1330717258 4321 dbSNP
rs1344020183 4322 dbSNP
rs1196064674 4324 dbSNP
rs1281164432 4325 dbSNP
rs755438090 4326 dbSNP
rs1331615814 4334 dbSNP
rs1303403984 4338 dbSNP
rs1254187914 4358 dbSNP
rs1023890247 4360 dbSNP
rs1454166367 4360 dbSNP
rs1006181141 4361 dbSNP
rs1475929870 4362 dbSNP
rs1380444780 4376 dbSNP
rs1167592825 4380 dbSNP
rs887461430 4382 dbSNP
rs1027251515 4385 dbSNP
rs11557036 4391 dbSNP
rs934170797 4392 dbSNP
rs551271600 4396 dbSNP
rs1361410622 4401 dbSNP
rs531142866 4407 dbSNP
rs751909540 4408 dbSNP
rs562495261 4409 dbSNP
rs1034510010 4411 dbSNP
rs545526840 4414 dbSNP
rs1040218337 4424 dbSNP
rs1227836488 4425 dbSNP
rs1008729220 4427 dbSNP
rs183022680 4430 dbSNP
rs1404107677 4434 dbSNP
rs1273338922 4443 dbSNP
rs1176171492 4458 dbSNP
rs1467627763 4459 dbSNP
rs1050373341 4465 dbSNP
rs934321200 4488 dbSNP
rs1250407199 4489 dbSNP
rs946597580 4492 dbSNP
rs1470548297 4493 dbSNP
rs528797157 4503 dbSNP
rs978684114 4514 dbSNP
rs1371562183 4519 dbSNP
rs1473936705 4528 dbSNP
rs1165910367 4537 dbSNP
rs1052419481 4540 dbSNP
rs970355542 4554 dbSNP
rs192159477 4557 dbSNP
rs56364694 4567 dbSNP
rs1428405418 4568 dbSNP
rs993035686 4574 dbSNP
rs982729567 4578 dbSNP
rs959861857 4587 dbSNP
rs1035099931 4590 dbSNP
rs994285652 4595 dbSNP
rs1234808989 4604 dbSNP
rs1293497749 4605 dbSNP
rs1333564867 4607 dbSNP
rs961352684 4609 dbSNP
rs1263035578 4610 dbSNP
rs1486441599 4614 dbSNP
rs1205057682 4619 dbSNP
rs1260787096 4620 dbSNP
rs1260157926 4622 dbSNP
rs969589022 4639 dbSNP
rs1202635599 4643 dbSNP
rs1017370821 4658 dbSNP
rs1345520871 4678 dbSNP
rs1257025378 4683 dbSNP
rs56376929 4684 dbSNP
rs187719552 4687 dbSNP
rs1005566945 4689 dbSNP
rs1365464624 4692 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions TZM-bl
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM1462574. RNA binding protein: AGO2. Condition:TZM-bl ami BaL ...

- Whisnant AW; Bogerd HP; Flores O; Ho P; et al., 2013, mBio.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' uuGGUGGUCGGGUGAGg 5'
            |||::  ||||||| 
Target 5' acCCAUUCUCCCACUCu 3'
 		9 - 25
Article - Whisnant AW; Bogerd HP; Flores O; Ho P; et al.
- mBio, 2013
UNLABELLED: The question of how HIV-1 interfaces with cellular microRNA (miRNA) biogenesis and effector mechanisms has been highly controversial. Here, we first used deep sequencing of small RNAs present in two different infected cell lines (TZM-bl and C8166) and two types of primary human cells (CD4(+) peripheral blood mononuclear cells [PBMCs] and macrophages) to unequivocally demonstrate that HIV-1 does not encode any viral miRNAs. Perhaps surprisingly, we also observed that infection of T cells by HIV-1 has only a modest effect on the expression of cellular miRNAs at early times after infection. Comprehensive analysis of miRNA binding to the HIV-1 genome using the photoactivatable ribonucleoside-induced cross-linking and immunoprecipitation (PAR-CLIP) technique revealed several binding sites for cellular miRNAs, a subset of which were shown to be capable of mediating miRNA-mediated repression of gene expression. However, the main finding from this analysis is that HIV-1 transcripts are largely refractory to miRNA binding, most probably due to extensive viral RNA secondary structure. Together, these data demonstrate that HIV-1 neither encodes viral miRNAs nor strongly influences cellular miRNA expression, at least early after infection, and imply that HIV-1 transcripts have evolved to avoid inhibition by preexisting cellular miRNAs by adopting extensive RNA secondary structures that occlude most potential miRNA binding sites. IMPORTANCE: MicroRNAs (miRNAs) are a ubiquitous class of small regulatory RNAs that serve as posttranscriptional regulators of gene expression. Previous work has suggested that HIV-1 might subvert the function of the cellular miRNA machinery by expressing viral miRNAs or by dramatically altering the level of cellular miRNA expression. Using very sensitive approaches, we now demonstrate that neither of these ideas is in fact correct. Moreover, HIV-1 transcripts appear to largely avoid regulation by cellular miRNAs by adopting an extensive RNA secondary structure that occludes the ability of cellular miRNAs to interact with viral mRNAs. Together, these data suggest that HIV-1, rather than seeking to control miRNA function in infected cells, has instead evolved a mechanism to become largely invisible to cellular miRNA effector mechanisms.
LinkOut: [PMID: 23592263]
CLIP-seq Support 1 for dataset GSM1462574
Method / RBP PAR-CLIP / AGO2
Cell line / Condition TZM-bl / TZM-bl ami BaL
Location of target site ENST00000376621.3 | 3UTR | CUUCCUCUACCCAUUCUCCCACUCUGCACCUUAG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23592263 / GSE59944
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
84 hsa-miR-4481 Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT100715 TJAP1 tight junction associated protein 1 2 2
MIRT183589 ZC3H11A zinc finger CCCH-type containing 11A 2 2
MIRT338033 DAZAP2 DAZ associated protein 2 2 4
MIRT395796 SPCS3 signal peptidase complex subunit 3 2 2
MIRT443947 LRIT3 leucine rich repeat, Ig-like and transmembrane domains 3 2 2
MIRT450580 HIST1H2BG histone cluster 1 H2B family member g 2 6
MIRT451617 MEIS3P1 Meis homeobox 3 pseudogene 1 2 2
MIRT452331 EIF5AL1 eukaryotic translation initiation factor 5A-like 1 2 2
MIRT453279 EFTUD2 elongation factor Tu GTP binding domain containing 2 2 2
MIRT455212 GNL1 G protein nucleolar 1 (putative) 2 2
MIRT455470 LYPLA2 lysophospholipase II 2 2
MIRT456503 PFKFB2 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 2 2
MIRT456687 LDB1 LIM domain binding 1 2 2
MIRT456915 DDA1 DET1 and DDB1 associated 1 2 2
MIRT457603 IDS iduronate 2-sulfatase 2 2
MIRT457848 RNASEH2B ribonuclease H2 subunit B 2 4
MIRT458455 RPRM reprimo, TP53 dependent G2 arrest mediator homolog 2 2
MIRT460179 UNK unkempt family zinc finger 2 6
MIRT461465 SLC19A3 solute carrier family 19 member 3 2 2
MIRT464739 UBE2Q1 ubiquitin conjugating enzyme E2 Q1 2 2
MIRT465279 TRIM28 tripartite motif containing 28 2 2
MIRT468450 SETD1B SET domain containing 1B 2 2
MIRT468620 SUMO1 small ubiquitin-like modifier 1 2 6
MIRT469152 RNF121 ring finger protein 121 2 2
MIRT470073 PTGES2 prostaglandin E synthase 2 2 2
MIRT470172 PSMD11 proteasome 26S subunit, non-ATPase 11 2 4
MIRT473156 MLLT1 MLLT1, super elongation complex subunit 2 2
MIRT474308 LAMC1 laminin subunit gamma 1 2 2
MIRT474782 KIAA0895L KIAA0895 like 2 2
MIRT476484 GATAD2A GATA zinc finger domain containing 2A 2 2
MIRT477613 EFNA3 ephrin A3 2 2
MIRT479525 CDCA4 cell division cycle associated 4 2 2
MIRT479973 CARD10 caspase recruitment domain family member 10 2 2
MIRT480410 C19orf47 chromosome 19 open reading frame 47 2 2
MIRT480426 C17orf85 nuclear cap binding subunit 3 2 2
MIRT483573 SYT2 synaptotagmin 2 2 2
MIRT483664 QSOX2 quiescin sulfhydryl oxidase 2 2 4
MIRT484532 POLD3 DNA polymerase delta 3, accessory subunit 2 2
MIRT484616 SIX3 SIX homeobox 3 2 6
MIRT485897 ZFP36 ZFP36 ring finger protein 2 2
MIRT486505 MYH11 myosin heavy chain 11 2 2
MIRT487505 GRK5 G protein-coupled receptor kinase 5 2 2
MIRT488852 UBTF upstream binding transcription factor, RNA polymerase I 2 2
MIRT489464 MSC musculin 2 2
MIRT491170 LRP3 LDL receptor related protein 3 2 2
MIRT496627 TMEM67 transmembrane protein 67 2 2
MIRT497616 ANG angiogenin 2 2
MIRT497766 KIAA0895 KIAA0895 2 2
MIRT499680 MRE11A MRE11 homolog, double strand break repair nuclease 2 6
MIRT499774 SLC29A2 solute carrier family 29 member 2 2 2
MIRT501745 NSD1 nuclear receptor binding SET domain protein 1 2 2
MIRT504995 ZNF652 zinc finger protein 652 2 2
MIRT511664 HIST1H3C histone cluster 1 H3 family member c 2 2
MIRT511690 HIST1H2BO histone cluster 1 H2B family member o 2 4
MIRT511703 HIST1H2BL histone cluster 1 H2B family member l 2 4
MIRT511734 HIST1H2BE histone cluster 1 H2B family member e 2 8
MIRT512858 TBC1D13 TBC1 domain family member 13 2 2
MIRT513444 EMP1 epithelial membrane protein 1 2 6
MIRT515681 TFPI tissue factor pathway inhibitor 2 2
MIRT523529 GLUL glutamate-ammonia ligase 2 2
MIRT525546 PHB2 prohibitin 2 2 4
MIRT526209 SNX24 sorting nexin 24 2 2
MIRT531554 SRD5A1 steroid 5 alpha-reductase 1 2 2
MIRT533764 TMEM135 transmembrane protein 135 2 2
MIRT545582 SNRPA1 small nuclear ribonucleoprotein polypeptide A' 2 2
MIRT552434 ZNF460 zinc finger protein 460 2 2
MIRT561159 BCL2L12 BCL2 like 12 2 2
MIRT562345 EXOSC2 exosome component 2 2 2
MIRT570659 KDM6B lysine demethylase 6B 2 2
MIRT571076 TCHHL1 trichohyalin like 1 2 2
MIRT571330 TPCN2 two pore segment channel 2 2 2
MIRT571603 TOB2 transducer of ERBB2, 2 2 2
MIRT573013 RPP25 ribonuclease P and MRP subunit p25 2 2
MIRT609041 EP300 E1A binding protein p300 2 2
MIRT613398 DNAH17 dynein axonemal heavy chain 17 2 2
MIRT635589 TTC9C tetratricopeptide repeat domain 9C 2 2
MIRT661118 FPR1 formyl peptide receptor 1 2 2
MIRT690103 PNMA2 paraneoplastic Ma antigen 2 2 2
MIRT694972 PLAC8 placenta specific 8 2 2
MIRT695515 ALPI alkaline phosphatase, intestinal 2 2
MIRT695578 ASB16 ankyrin repeat and SOCS box containing 16 2 2
MIRT699570 SIT1 signaling threshold regulating transmembrane adaptor 1 2 2
MIRT701991 MIER3 MIER family member 3 2 2
MIRT725464 GRAP2 GRB2-related adaptor protein 2 2 2
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-4 Dexamethasone approved 5743 Microarray primary rat thymocytes 20847043 2010 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-4481 Platinum 23939 sensitive High Ovarian Cancer tissue
hsa-mir-4481 Androstenedione 6128 NSC9563 sensitive cell line (MCF-7)
hsa-mir-4481 Tamoxifen 2733525 NSC180973 approved resistant cell line (MCF7)
hsa-mir-4481 Cisplatin 5460033 NSC119875 approved resistant cell line (BxPC3)
hsa-miR-4481 Cisplatin 5460033 NSC119875 approved resistant cell line (CAL-27) (cytosolic RNA)
hsa-miR-4481 Osimertinib 71496458 NSC779217 approved sensitive cell line (H1975)
hsa-miR-4481 Neoadjuvant chemotherapy sensitive tissue (breast cancer)
hsa-miR-4481 Gemcitabine 60750 NSC613327 approved resistant cell line (PANC-1) (100 ng/ml)
hsa-miR-4481 Gemcitabine 60750 NSC613327 approved sensitive cell line (PANC-1) (1500 ng/ml)

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