miRTarBase - #MIRT455447


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pre-miRNA Information
pre-miRNA hsa-mir-2110   
Genomic Coordinates chr10: 114174105 - 114174179
Synonyms hsa-mir-2110, MIR2110
Description Homo sapiens miR-2110 stem-loop
Comment Zhu et al. incorrectly referred to this sequence as mir-1309 in . This sequence is unrelated to MIR1309 in plants.
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-2110
Sequence 8| UUGGGGAAACGGCCGCUGAGUG |29
Evidence Experimental
Experiments 454
DRVs in miRNA
Mutant ID Mutant Position Mutant Source
COSN31660996 18 COSMIC
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1434681640 4 dbSNP
rs1418383763 6 dbSNP
rs745914474 7 dbSNP
rs1178383827 8 dbSNP
rs1412803607 9 dbSNP
rs114530801 10 dbSNP
rs1168982220 11 dbSNP
rs573692968 14 dbSNP
rs1246581316 15 dbSNP
rs1431021422 16 dbSNP
rs1188283086 17 dbSNP
rs1476834649 19 dbSNP
rs192664871 19 dbSNP
Putative Targets

miRNA Expression profile
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol EPB41L4B   
Synonyms CG1, EHM2
Description erythrocyte membrane protein band 4.1 like 4B
Transcript NM_019114   
Other Transcripts NM_018424   
Expression
Putative miRNA Targets on EPB41L4B
3'UTR of EPB41L4B
(miRNA target sites are highlighted)		 
>EPB41L4B|NM_019114|3'UTR
   1 AATTCTCCCCTTGTCACCTGGAAGATGGCATGGTGCCTTCTGTCCGTCTTCTTTCTTCGGGCTTTGTGTGCTCACTCTAG
  81 CACAGCATACAAGTGTGTGCTCTGTTCGCCCAGGTCTCCATGGTTAGTTGAAGCCAATTTCTGGCTTGACTTTTATGGGA
 161 AAAGTTATTTTATGTCTCCTAAGCATTAGAGTTTTTCTATTACTCTATGTAGTTGAGACAGGATTTGATAAGTCTAGGAA
 241 AAGAAAGATGGGAAAACGGGATTCCTTTTCAGAAGTACCTGTGTGTATCTGTTAATAACCACAGGGGTTAATATGATGTA
 321 GGATCTTTTACTATCAATTTCAACCATTTGATTTTGTATGATTGAAACTTGCACCGAGCTTTGACTGTTTGTTAAAGAGT
 401 CATTTTTAATGAAAGAATAATTCTTTATTGCTGGTTTTTCATTTACACTGATAAATACACAGATCTTATAAAGTCTTTAA
 481 CATTCATTTGTATTCAGATGTGAGTAGAAGAACTAAAAAAAGAAAGTTACATATCACTATGACTGAAGGTACTTCAGCTT
 561 AATCTGAAATATAATTTAACTTGTGAACTCCTTGGATATGATATTATTTGGAATAAACAGAATTTATCATTGAACCCAAA
 641 GTAGGAAATGATAGCTTACATTGTCTAAAAATCCTTACAAGGTTAAGATGATTCAATATCAAGAAGATTCAGAAAATTAT
 721 TTCTAAAGTTGATCGATTCATGTCGTATTGATAGAATCTTGACCAGAAGAAATTTTGCTCTTTTTATATAGTTTCAAGAA
 801 ATGTGTTTTTAAATTTTTATTAATGCACTTGAACAACTTTGCAGGAATAAAGCAACCCCCTAACCACAAAATATCCCTCT
 881 AAATTAGTTCCCTAGCTTTCTCAATGAATACACACATATTTTTACATAGCTATGATCGTTGTGTACATTCTCCTTTGTTT
 961 TACTTCTCGGCCTAACACTTGTCTCCTCTTGTCAACACAGATTCTACTCTCACCAATTTAAATGTCTTTATATCCATGTA
1041 ACATGGGTAACCTCACTTCACCCCATTATTAGATATTTGAGTTATATCTAATTTTTCACTCTTATAAATAGTGCTGCTAT
1121 GAATGTCTGTAAAAAAAAAAAACTGCTCCTTCTTTTGGATTATTCCCTTAGGAATATCTCCAAAGAGGGATTACAAGGTC
1201 AAAGAGCATGAAGTATTTTATAGCTCTTGTTTTATATTGCCAGATTGCTTTCTAGAAAGATCCAATCTTTGGGTTGGAAG
1281 GACCTTAAAGGTCATCTAGTTTAGCCTCCCCACCCCCTCTGAATGCTTGAATCCCCTCGACAATTTATGATGCCACCAGC
1361 AATGTATAAGCATTTCTGTTTACCAATAGCTCTGCCAGTATTGGGTTTTGCCATTTTTATTTATTTTTGCTAGTTTAATA
1441 GGTATGTATAGTTGTTCTTGAAGAGTTGTTTTATTTCATTAATTGCTAGCAAGGCTGAGCACTTTTCCATGTGATGATTT
1521 ACTAGTTGTATTTCCTTGTGTGTAAAATGTTCATTCATTTCTTATGACCACTTGTTAAGAGGAACTGATCTCATATATTT
1601 GTATCAGAACTGTATTTTTATGTTATATTGTATAGTTTGCTCTCCTGCCCCTCTCCTTAAAACTGAATGGTGCCAATAAT
1681 TTGATACTAATGACTACAAAAAAAGGTAATGCCTCATTTACTAGTATTGTTGTAAAATGAGGAATGTATGTGAATATTCA
1761 GATAACCGAGGATTAACCCTTTAAGTGCTGAATCTTTAAAATTTTAATATATTTTTTTTTGAGGGAAATCTTTCTAAAAT
1841 GTATTACGCACTTCCCTGCCTTAGTAAACAGAGTATACTGGAGAGTATTTAACCTTTTCTTGATGAGTCATGGTCATGAT
1921 TATAAACATCAGCCCCTTTTATACCTTGGTACGGTGCAGTGATATCATTAAGAGCTATCAATATGTGTAGGGCTTGGCTT
2001 GGCCTTTTATAGGATATTATGCTGTTCTCACTGATGGTTTTTTACTGCTCTCTGCTCTGTCAGTGGAGCTATCCGGGGCA
2081 ATTGTAGCGTTTGGGTCCTTTTACCCCTATGTCCCCCGGCTATACTTTTAAAACAGCTTTAGCTGTTCTTTATCTTGTGC
2161 ACATGATACAAAATATGTTCCCGTACAATATGGGGCTGTCACTTCTTGCCAACCCAGCACCCTCTTCCTCTTCTAACCTG
2241 CTTTCTGAGGCTTCTGCTCTTCACCTCCTGCTCGCTGATGGAAACCTCCAGGGCAAAGCTGAAGGTTTCTTGGGGAAGCC
2321 AGGAAAGCCAGTATTTCCTATGTGTCAGATCTGCTTGGCTTCCAAGAAGGGATGCATGGGCTTTTTGGCCAGTGTTTCCA
2401 GGAGGCTCTGGGCTTCCTGCTTCTTCCCCGCTTCCCCCAGAGTTCACAGATGTTGAAGTTTCTGAAGGTTGACGTCACTG
2481 GAAGTCTGACCACAAACAAGTTGGCTGTTACTGTATTTGAAACCCAGTACCTTTGGCAGCTCACCTCTAACCAGTAAAAT
2561 AAGAGGATTCCATGGTTTCAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' gugagucgccGGCAAAGGGGuu 5'
                    ||| ||||||  
Target 5' tgcttcttccCCGCTTCCCCca 3'
 2418 - 2439 132.00 -14.40
2 
miRNA  3' guGAGUCGCCGGCAAAGGGGuu 5'
            | ||||  ||  ||||:|  
Target 5' aaCCCAGCACCCTCTTCCTCtt 3'
 2211 - 2232 124.00 -14.60
3 
miRNA  3' gugagucgccggcaAAGGGGUu 5'
                        |||||:| 
Target 5' tccctctaaattagTTCCCTAg 3'
 874 - 895 124.00 -11.03
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30490745 7 COSMIC
COSN15314403 46 COSMIC
COSN8810919 46 COSMIC
COSN30142759 100 COSMIC
COSN30615634 109 COSMIC
COSN31482609 155 COSMIC
COSN30134930 170 COSMIC
COSN31527018 207 COSMIC
COSN31536490 259 COSMIC
COSN22636213 270 COSMIC
COSN22798464 388 COSMIC
COSN21547124 752 COSMIC
COSN29219074 754 COSMIC
COSN31480562 766 COSMIC
COSN17181890 777 COSMIC
COSN20106456 1130 COSMIC
COSN31549142 1146 COSMIC
COSN31597137 1185 COSMIC
COSN30539879 1321 COSMIC
COSN31553306 1338 COSMIC
COSN29894337 1649 COSMIC
COSN31538129 1697 COSMIC
COSN19159655 1785 COSMIC
COSN6375344 1846 COSMIC
COSN21086488 1851 COSMIC
COSN22830460 1927 COSMIC
COSN24294981 1953 COSMIC
COSN31963090 2088 COSMIC
COSN25132674 2114 COSMIC
COSN26162085 2137 COSMIC
COSN17078417 2223 COSMIC
rs7858727 706 GWAS
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1392746028 7 dbSNP
rs777326312 9 dbSNP
rs187581121 10 dbSNP
rs1307159416 24 dbSNP
rs768062137 26 dbSNP
rs1407087319 28 dbSNP
rs753233892 36 dbSNP
rs1332325974 38 dbSNP
rs1372934599 45 dbSNP
rs10979727 46 dbSNP
rs752085930 49 dbSNP
rs766410482 50 dbSNP
rs1158948490 51 dbSNP
rs763065467 52 dbSNP
rs760030873 58 dbSNP
rs1177437554 59 dbSNP
rs1272396092 62 dbSNP
rs1444765219 66 dbSNP
rs542698660 68 dbSNP
rs1439411404 69 dbSNP
rs760515309 70 dbSNP
rs575363931 73 dbSNP
rs1251646396 74 dbSNP
rs1441486968 75 dbSNP
rs1278288550 77 dbSNP
rs1206150970 79 dbSNP
rs1356458034 81 dbSNP
rs370230656 83 dbSNP
rs554495314 88 dbSNP
rs1240092120 89 dbSNP
rs772004505 92 dbSNP
rs1250578293 93 dbSNP
rs1317260906 94 dbSNP
rs745750295 95 dbSNP
rs10733569 102 dbSNP
rs770533099 104 dbSNP
rs748852202 105 dbSNP
rs755786289 107 dbSNP
rs773591239 108 dbSNP
rs1157921196 109 dbSNP
rs1425253023 118 dbSNP
rs568401983 119 dbSNP
rs755369183 121 dbSNP
rs537687686 125 dbSNP
rs1242405681 130 dbSNP
rs1416266249 135 dbSNP
rs182877418 139 dbSNP
rs1169191369 144 dbSNP
rs1426627733 145 dbSNP
rs1460708519 155 dbSNP
rs878927224 156 dbSNP
rs558575504 158 dbSNP
rs1193969892 159 dbSNP
rs190245597 160 dbSNP
rs1379986186 161 dbSNP
rs1453585134 164 dbSNP
rs187333822 173 dbSNP
rs910432515 174 dbSNP
rs1220390884 180 dbSNP
rs541669569 188 dbSNP
rs1212081243 192 dbSNP
rs761089596 199 dbSNP
rs933287842 202 dbSNP
rs1481771223 203 dbSNP
rs1040897897 210 dbSNP
rs1251934037 211 dbSNP
rs1202011389 218 dbSNP
rs182944216 228 dbSNP
rs1485726370 229 dbSNP
rs1306254426 236 dbSNP
rs1209590090 239 dbSNP
rs1254735456 247 dbSNP
rs1306286165 251 dbSNP
rs908041127 253 dbSNP
rs115419201 257 dbSNP
rs568904649 258 dbSNP
rs1427037337 259 dbSNP
rs930912557 260 dbSNP
rs1359908477 262 dbSNP
rs1434313716 274 dbSNP
rs1311214925 278 dbSNP
rs533145431 286 dbSNP
rs879717134 299 dbSNP
rs925384145 311 dbSNP
rs59755208 321 dbSNP
rs1289312888 322 dbSNP
rs980704678 333 dbSNP
rs1212539490 334 dbSNP
rs556140415 337 dbSNP
rs1392747237 338 dbSNP
rs1233103584 357 dbSNP
rs191161057 358 dbSNP
rs958405712 361 dbSNP
rs1217135989 362 dbSNP
rs1025797129 374 dbSNP
rs1485108007 375 dbSNP
rs1377130142 379 dbSNP
rs774602542 391 dbSNP
rs1171948946 397 dbSNP
rs1174222325 397 dbSNP
rs1433817062 399 dbSNP
rs1382255704 400 dbSNP
rs1393015178 402 dbSNP
rs1318919433 408 dbSNP
rs1344586772 415 dbSNP
rs565545198 419 dbSNP
rs995689727 433 dbSNP
rs1295137489 438 dbSNP
rs981608067 440 dbSNP
rs1439723149 444 dbSNP
rs150716024 455 dbSNP
rs1020555695 456 dbSNP
rs1251589173 461 dbSNP
rs1282910387 470 dbSNP
rs1315700284 473 dbSNP
rs1010124307 481 dbSNP
rs1176634684 482 dbSNP
rs1482117541 490 dbSNP
rs1468267699 495 dbSNP
rs1192024281 500 dbSNP
rs957261216 504 dbSNP
rs1240209249 505 dbSNP
rs1470623179 517 dbSNP
rs1032951192 522 dbSNP
rs1405878164 523 dbSNP
rs1283038568 524 dbSNP
rs1212251810 530 dbSNP
rs996175679 534 dbSNP
rs1460689285 536 dbSNP
rs1323505314 538 dbSNP
rs1347850429 540 dbSNP
rs528795024 542 dbSNP
rs1241703518 547 dbSNP
rs560927080 552 dbSNP
rs1230534357 580 dbSNP
rs1274314542 583 dbSNP
rs900535558 588 dbSNP
rs1305864013 589 dbSNP
rs1007351063 590 dbSNP
rs888772294 596 dbSNP
rs749339083 599 dbSNP
rs1389139671 602 dbSNP
rs1438678140 617 dbSNP
rs1181344960 621 dbSNP
rs1231264673 627 dbSNP
rs796164090 627 dbSNP
rs1040424689 634 dbSNP
rs1190018050 635 dbSNP
rs1051469648 642 dbSNP
rs1460835329 647 dbSNP
rs1009397192 651 dbSNP
rs1313011956 652 dbSNP
rs1414061125 660 dbSNP
rs886583404 662 dbSNP
rs1373629841 678 dbSNP
rs879339977 681 dbSNP
rs1352295159 682 dbSNP
rs913838551 683 dbSNP
rs759974422 687 dbSNP
rs1454132534 698 dbSNP
rs1355430631 704 dbSNP
rs7858727 706 dbSNP
rs930837998 715 dbSNP
rs1340423791 723 dbSNP
rs1195445681 729 dbSNP
rs980819233 734 dbSNP
rs948194936 735 dbSNP
rs141154817 737 dbSNP
rs572681090 739 dbSNP
rs1055339108 744 dbSNP
rs936975357 745 dbSNP
rs1185641001 749 dbSNP
rs951691419 750 dbSNP
rs1351892763 757 dbSNP
rs148207624 758 dbSNP
rs1417011614 763 dbSNP
rs974201997 768 dbSNP
rs1313028893 778 dbSNP
rs1249909685 779 dbSNP
rs1226169064 787 dbSNP
rs1374309621 790 dbSNP
rs1413487230 791 dbSNP
rs1336548397 795 dbSNP
rs777612355 803 dbSNP
rs1227085957 805 dbSNP
rs1018488957 810 dbSNP
rs1413699057 812 dbSNP
rs1350368914 813 dbSNP
rs1279773732 814 dbSNP
rs1484695606 820 dbSNP
rs1007709521 824 dbSNP
rs544351694 826 dbSNP
rs913010210 828 dbSNP
rs1192254717 832 dbSNP
rs1371125961 835 dbSNP
rs997204624 836 dbSNP
rs1173812420 856 dbSNP
rs1320209819 858 dbSNP
rs576983731 859 dbSNP
rs892350026 865 dbSNP
rs1160822871 875 dbSNP
rs1382121062 876 dbSNP
rs1052305825 880 dbSNP
rs1373626888 881 dbSNP
rs1441926985 890 dbSNP
rs1302905887 892 dbSNP
rs763125307 895 dbSNP
rs1241339739 907 dbSNP
rs903686340 915 dbSNP
rs1286950357 926 dbSNP
rs988623163 937 dbSNP
rs1420374699 938 dbSNP
rs1165729245 943 dbSNP
rs1259417995 953 dbSNP
rs957229089 957 dbSNP
rs1469594086 963 dbSNP
rs1032919100 964 dbSNP
rs773286766 968 dbSNP
rs762487782 969 dbSNP
rs185862130 977 dbSNP
rs1452160957 978 dbSNP
rs918024978 989 dbSNP
rs1448131554 990 dbSNP
rs1261437289 991 dbSNP
rs1453743383 993 dbSNP
rs1157278876 1014 dbSNP
rs1019380082 1017 dbSNP
rs1462250908 1022 dbSNP
rs1207302349 1036 dbSNP
rs7873921 1040 dbSNP
rs918631326 1056 dbSNP
rs1307870777 1057 dbSNP
rs1232080025 1061 dbSNP
rs1238252219 1065 dbSNP
rs886507161 1065 dbSNP
rs1266120090 1074 dbSNP
rs1026440221 1077 dbSNP
rs1214148726 1086 dbSNP
rs868613321 1090 dbSNP
rs994959670 1094 dbSNP
rs1487337457 1097 dbSNP
rs974316393 1099 dbSNP
rs1417963456 1112 dbSNP
rs1180318527 1116 dbSNP
rs1475804924 1119 dbSNP
rs899348850 1124 dbSNP
rs1164743748 1125 dbSNP
rs76915265 1130 dbSNP
rs1353681184 1131 dbSNP
rs78952864 1131 dbSNP
rs1271808660 1133 dbSNP
rs1228036615 1140 dbSNP
rs1018436627 1142 dbSNP
rs1389692605 1143 dbSNP
rs200071485 1143 dbSNP
rs1325822013 1146 dbSNP
rs748096517 1155 dbSNP
rs868607947 1157 dbSNP
rs985665369 1161 dbSNP
rs1206186632 1171 dbSNP
rs553267857 1174 dbSNP
rs1293167779 1180 dbSNP
rs1055266474 1181 dbSNP
rs1396885956 1185 dbSNP
rs1259005119 1191 dbSNP
rs1326869116 1192 dbSNP
rs938284492 1197 dbSNP
rs1412085774 1204 dbSNP
rs1430626127 1205 dbSNP
rs1171421677 1206 dbSNP
rs1460944369 1211 dbSNP
rs1372768375 1213 dbSNP
rs561714399 1220 dbSNP
rs566799448 1245 dbSNP
rs1314914568 1248 dbSNP
rs1376126848 1254 dbSNP
rs752401976 1265 dbSNP
rs1376734552 1268 dbSNP
rs1216162997 1280 dbSNP
rs1476025496 1289 dbSNP
rs1373068421 1290 dbSNP
rs1030089696 1292 dbSNP
rs145975938 1305 dbSNP
rs1347891089 1306 dbSNP
rs1210838517 1309 dbSNP
rs1236179456 1310 dbSNP
rs536292884 1311 dbSNP
rs1187512365 1313 dbSNP
rs1447949822 1315 dbSNP
rs912969311 1316 dbSNP
rs1175693307 1319 dbSNP
rs988593388 1326 dbSNP
rs568893708 1329 dbSNP
rs764832082 1333 dbSNP
rs370041486 1338 dbSNP
rs377454200 1339 dbSNP
rs550406434 1341 dbSNP
rs1045274977 1348 dbSNP
rs1432808896 1350 dbSNP
rs759073527 1352 dbSNP
rs1360941011 1356 dbSNP
rs532705345 1366 dbSNP
rs142920432 1370 dbSNP
rs1348006105 1378 dbSNP
rs547632158 1386 dbSNP
rs974632216 1391 dbSNP
rs1319321999 1400 dbSNP
rs1217110518 1413 dbSNP
rs184129383 1432 dbSNP
rs1463770266 1442 dbSNP
rs1195765018 1448 dbSNP
rs529180614 1451 dbSNP
rs987876107 1454 dbSNP
rs1189620625 1457 dbSNP
rs190754977 1460 dbSNP
rs1410240547 1464 dbSNP
rs1402390271 1466 dbSNP
rs1159660538 1467 dbSNP
rs542781337 1468 dbSNP
rs1295957738 1486 dbSNP
rs1455402000 1494 dbSNP
rs115355281 1499 dbSNP
rs34632045 1509 dbSNP
rs1371328706 1515 dbSNP
rs561640552 1516 dbSNP
rs1272631462 1521 dbSNP
rs770554568 1523 dbSNP
rs1374798328 1526 dbSNP
rs1329640107 1540 dbSNP
rs554020970 1544 dbSNP
rs899316238 1549 dbSNP
rs1306861975 1552 dbSNP
rs1396324107 1554 dbSNP
rs1215989260 1556 dbSNP
rs1033823429 1567 dbSNP
rs1167297299 1569 dbSNP
rs1468253328 1590 dbSNP
rs773504786 1594 dbSNP
rs1234677655 1596 dbSNP
rs1470531303 1601 dbSNP
rs1461127187 1609 dbSNP
rs955569447 1612 dbSNP
rs1411217284 1616 dbSNP
rs372364358 1618 dbSNP
rs879033542 1624 dbSNP
rs373185518 1630 dbSNP
rs1471550496 1632 dbSNP
rs1436915101 1634 dbSNP
rs1166912981 1652 dbSNP
rs1394925626 1653 dbSNP
rs1396046679 1653 dbSNP
rs922800652 1662 dbSNP
rs1321096369 1664 dbSNP
rs1355802485 1667 dbSNP
rs1442233769 1671 dbSNP
rs1193446228 1684 dbSNP
rs772496126 1686 dbSNP
rs138402548 1688 dbSNP
rs1476832712 1691 dbSNP
rs1234307891 1692 dbSNP
rs906760011 1693 dbSNP
rs1181825877 1694 dbSNP
rs1436724041 1695 dbSNP
rs1272329635 1697 dbSNP
rs762015905 1700 dbSNP
rs1212910345 1704 dbSNP
rs1348557228 1705 dbSNP
rs1279342024 1710 dbSNP
rs563771570 1712 dbSNP
rs956481845 1713 dbSNP
rs1438589028 1715 dbSNP
rs1354784427 1726 dbSNP
rs768950341 1728 dbSNP
rs1030603957 1737 dbSNP
rs1189906479 1744 dbSNP
rs1418306909 1748 dbSNP
rs545184444 1754 dbSNP
rs891466975 1763 dbSNP
rs967907724 1766 dbSNP
rs1052813265 1767 dbSNP
rs935751698 1768 dbSNP
rs578072159 1771 dbSNP
rs925745121 1772 dbSNP
rs1417170887 1778 dbSNP
rs1313978452 1785 dbSNP
rs1340274100 1787 dbSNP
rs1442016469 1802 dbSNP
rs539368251 1803 dbSNP
rs145827807 1809 dbSNP
rs943258426 1811 dbSNP
rs1056732132 1812 dbSNP
rs185881120 1812 dbSNP
rs911791958 1813 dbSNP
rs1038351923 1821 dbSNP
rs549818524 1821 dbSNP
rs941350718 1821 dbSNP
rs1185233848 1825 dbSNP
rs1243623141 1827 dbSNP
rs950737905 1828 dbSNP
rs1050005867 1836 dbSNP
rs1417129182 1839 dbSNP
rs34322059 1840 dbSNP
rs1376664823 1841 dbSNP
rs934270200 1847 dbSNP
rs1173386391 1848 dbSNP
rs554912142 1849 dbSNP
rs1402172069 1855 dbSNP
rs1394794518 1858 dbSNP
rs1409617503 1871 dbSNP
rs149006499 1875 dbSNP
rs181709882 1876 dbSNP
rs1295627695 1884 dbSNP
rs1373314851 1892 dbSNP
rs1248951942 1893 dbSNP
rs1255456003 1902 dbSNP
rs1344297526 1907 dbSNP
rs1033748415 1914 dbSNP
rs556952493 1915 dbSNP
rs1286092140 1927 dbSNP
rs138975445 1943 dbSNP
rs1485953025 1944 dbSNP
rs1002781266 1951 dbSNP
rs150183053 1952 dbSNP
rs746954775 1953 dbSNP
rs1009822404 1956 dbSNP
rs1193796337 1983 dbSNP
rs1376557755 1988 dbSNP
rs891443672 1991 dbSNP
rs564198671 2009 dbSNP
rs1160725502 2011 dbSNP
rs67412728 2016 dbSNP
rs1456999147 2020 dbSNP
rs1318929110 2022 dbSNP
rs1397008132 2026 dbSNP
rs1441903069 2029 dbSNP
rs1300695939 2030 dbSNP
rs999890369 2038 dbSNP
rs1329349190 2046 dbSNP
rs1231017604 2049 dbSNP
rs1281166381 2056 dbSNP
rs1224518172 2070 dbSNP
rs1329755706 2071 dbSNP
rs960932659 2073 dbSNP
rs572637957 2074 dbSNP
rs747891986 2075 dbSNP
rs188907208 2076 dbSNP
rs1213862190 2077 dbSNP
rs778589522 2079 dbSNP
rs943164007 2083 dbSNP
rs1266056800 2087 dbSNP
rs754597432 2088 dbSNP
rs911733289 2089 dbSNP
rs1184629753 2097 dbSNP
rs897210401 2102 dbSNP
rs1235274060 2105 dbSNP
rs1038466413 2109 dbSNP
rs1356594258 2109 dbSNP
rs549291626 2117 dbSNP
rs530897787 2118 dbSNP
rs563515527 2134 dbSNP
rs1319442420 2137 dbSNP
rs753408962 2152 dbSNP
rs901438709 2159 dbSNP
rs551778792 2165 dbSNP
rs1053186778 2167 dbSNP
rs765857822 2169 dbSNP
rs755518928 2175 dbSNP
rs1351105288 2177 dbSNP
rs934836837 2183 dbSNP
rs1286238252 2185 dbSNP
rs926165168 2186 dbSNP
rs1245101903 2189 dbSNP
rs926701116 2215 dbSNP
rs980886609 2220 dbSNP
rs971263236 2231 dbSNP
rs979144420 2240 dbSNP
rs1197077999 2257 dbSNP
rs757392180 2273 dbSNP
rs1025157824 2274 dbSNP
rs1180071092 2280 dbSNP
rs1010202014 2286 dbSNP
rs1164496224 2293 dbSNP
rs750942076 2298 dbSNP
rs1032636051 2300 dbSNP
rs1463719573 2302 dbSNP
rs767868752 2313 dbSNP
rs762258419 2314 dbSNP
rs904198542 2338 dbSNP
rs1214891028 2341 dbSNP
rs749439603 2347 dbSNP
rs1464601766 2362 dbSNP
rs1266481949 2386 dbSNP
rs1306060174 2387 dbSNP
rs1215561913 2388 dbSNP
rs1396438799 2391 dbSNP
rs140938624 2392 dbSNP
rs1311709003 2400 dbSNP
rs990911176 2411 dbSNP
rs1335579406 2416 dbSNP
rs1340797249 2421 dbSNP
rs1203665545 2426 dbSNP
rs774833049 2427 dbSNP
rs1007328283 2429 dbSNP
rs764478875 2430 dbSNP
rs1254498225 2432 dbSNP
rs186709253 2434 dbSNP
rs972523052 2471 dbSNP
rs929165847 2473 dbSNP
rs897743882 2474 dbSNP
rs1434849453 2488 dbSNP
rs1385902986 2498 dbSNP
rs1377244721 2501 dbSNP
rs147686875 2507 dbSNP
rs1302105612 2509 dbSNP
rs1376622031 2512 dbSNP
rs1383593661 2524 dbSNP
rs1248440970 2530 dbSNP
rs1297812216 2535 dbSNP
rs1363983201 2545 dbSNP
rs1225604375 2555 dbSNP
rs1005625723 2572 dbSNP
rs10759332 2573 dbSNP
rs1348773383 2574 dbSNP
rs926627662 2576 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions TZM-bl
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM1462574. RNA binding protein: AGO2. Condition:TZM-bl ami BaL ...

- Whisnant AW; Bogerd HP; Flores O; Ho P; et al., 2013, mBio.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' guGAGUCGCCGG---CAAAGGGGUu 5'
            :||| :| ||    |||||||| 
Target 5' ccUUCAUUGACCUCAUUUUCCCCAu 3'
 		9 - 33
2 
miRNA  3' gugagucgccGGCAAAGGGguu 5'
                    :| ||||||   
Target 5' ----------UCAUUUCCCcuu 3'
 		1 - 12
Article - Whisnant AW; Bogerd HP; Flores O; Ho P; et al.
- mBio, 2013
UNLABELLED: The question of how HIV-1 interfaces with cellular microRNA (miRNA) biogenesis and effector mechanisms has been highly controversial. Here, we first used deep sequencing of small RNAs present in two different infected cell lines (TZM-bl and C8166) and two types of primary human cells (CD4(+) peripheral blood mononuclear cells [PBMCs] and macrophages) to unequivocally demonstrate that HIV-1 does not encode any viral miRNAs. Perhaps surprisingly, we also observed that infection of T cells by HIV-1 has only a modest effect on the expression of cellular miRNAs at early times after infection. Comprehensive analysis of miRNA binding to the HIV-1 genome using the photoactivatable ribonucleoside-induced cross-linking and immunoprecipitation (PAR-CLIP) technique revealed several binding sites for cellular miRNAs, a subset of which were shown to be capable of mediating miRNA-mediated repression of gene expression. However, the main finding from this analysis is that HIV-1 transcripts are largely refractory to miRNA binding, most probably due to extensive viral RNA secondary structure. Together, these data demonstrate that HIV-1 neither encodes viral miRNAs nor strongly influences cellular miRNA expression, at least early after infection, and imply that HIV-1 transcripts have evolved to avoid inhibition by preexisting cellular miRNAs by adopting extensive RNA secondary structures that occlude most potential miRNA binding sites. IMPORTANCE: MicroRNAs (miRNAs) are a ubiquitous class of small regulatory RNAs that serve as posttranscriptional regulators of gene expression. Previous work has suggested that HIV-1 might subvert the function of the cellular miRNA machinery by expressing viral miRNAs or by dramatically altering the level of cellular miRNA expression. Using very sensitive approaches, we now demonstrate that neither of these ideas is in fact correct. Moreover, HIV-1 transcripts appear to largely avoid regulation by cellular miRNAs by adopting an extensive RNA secondary structure that occludes the ability of cellular miRNAs to interact with viral mRNAs. Together, these data suggest that HIV-1, rather than seeking to control miRNA function in infected cells, has instead evolved a mechanism to become largely invisible to cellular miRNA effector mechanisms.
LinkOut: [PMID: 23592263]
CLIP-seq Support 1 for dataset GSM1462574
Method / RBP PAR-CLIP / AGO2
Cell line / Condition TZM-bl / TZM-bl ami BaL
Location of target site ENST00000374557.4 | 3UTR | UCAUUUCCCCUUCAUUGACCUCAUUUUCCCCAUCUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23592263 / GSE59944
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
UCEC 0.697 0 0.765 0 18 Click to see details
THCA 0.302 0.01 0.242 0.03 58 Click to see details
LIHC -0.31 0.02 -0.194 0.1 45 Click to see details
STAD 0.356 0.03 0.336 0.03 30 Click to see details
ESCA 0.538 0.04 0.545 0.04 11 Click to see details
BRCA 0.182 0.09 0.166 0.11 58 Click to see details
LUAD 0.422 0.09 0.315 0.16 12 Click to see details
BLCA 0.347 0.1 0.396 0.07 15 Click to see details
PCPG 0.933 0.12 1.000 0.5 3 Click to see details
KIRC 0.155 0.13 0.027 0.42 53 Click to see details
CESC 0.858 0.17 1.000 0.5 3 Click to see details
KIRP -0.123 0.26 -0.163 0.19 30 Click to see details
PRAD 0.093 0.3 0.036 0.42 35 Click to see details
HNSC 0.083 0.31 -0.091 0.29 39 Click to see details
CHOL 0.257 0.31 0.257 0.31 6 Click to see details
LUSC -0.095 0.31 -0.094 0.31 29 Click to see details
COAD 0.544 0.32 1.000 0.5 3 Click to see details
PAAD -0.496 0.33 -0.500 0.33 3 Click to see details
KICH -0.031 0.44 -0.106 0.31 24 Click to see details
KICH -0.031 0.44 -0.106 0.31 24 Click to see details
KICH -0.031 0.44 -0.106 0.31 24 Click to see details
96 hsa-miR-2110 Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT035757 BRD4 bromodomain containing 4 1 1
MIRT035758 NCOR2 nuclear receptor corepressor 2 1 1
MIRT035759 FASN fatty acid synthase 1 1
MIRT035760 C10orf118 coiled-coil domain containing 186 1 1
MIRT055403 SHOC2 SHOC2, leucine rich repeat scaffold protein 2 6
MIRT066205 MARCH9 membrane associated ring-CH-type finger 9 2 2
MIRT079365 CCDC137 coiled-coil domain containing 137 2 2
MIRT081180 MIDN midnolin 2 4
MIRT082397 HNRNPUL1 heterogeneous nuclear ribonucleoprotein U like 1 2 4
MIRT089000 BCL11A B-cell CLL/lymphoma 11A 2 2
MIRT133706 SKI SKI proto-oncogene 2 4
MIRT160053 TET3 tet methylcytosine dioxygenase 3 2 4
MIRT180853 RPRD2 regulation of nuclear pre-mRNA domain containing 2 2 2
MIRT263243 SGPL1 sphingosine-1-phosphate lyase 1 2 2
MIRT285532 CDT1 chromatin licensing and DNA replication factor 1 2 2
MIRT317152 E2F3 E2F transcription factor 3 2 4
MIRT321166 EIF4H eukaryotic translation initiation factor 4H 2 2
MIRT441482 NCEH1 neutral cholesterol ester hydrolase 1 2 2
MIRT443884 CNKSR3 CNKSR family member 3 2 2
MIRT445877 WBP1L WW domain binding protein 1 like 2 2
MIRT446195 GTPBP4 GTP binding protein 4 2 2
MIRT449308 MRO maestro 2 2
MIRT450301 DRAXIN dorsal inhibitory axon guidance protein 2 2
MIRT450512 EMX1 empty spiracles homeobox 1 2 2
MIRT451534 CIAPIN1 cytokine induced apoptosis inhibitor 1 2 2
MIRT451820 ALDH3B1 aldehyde dehydrogenase 3 family member B1 2 2
MIRT452239 TRAM1 translocation associated membrane protein 1 2 2
MIRT454207 HLA-A major histocompatibility complex, class I, A 2 2
MIRT455447 EPB41L4B erythrocyte membrane protein band 4.1 like 4B 2 2
MIRT456496 PFKFB2 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 2 2
MIRT457656 SERINC1 serine incorporator 1 2 2
MIRT459819 TPP1 tripeptidyl peptidase 1 2 2
MIRT460556 FEM1A fem-1 homolog A 2 2
MIRT462561 STS steroid sulfatase 2 2
MIRT462986 ZNF740 zinc finger protein 740 2 2
MIRT464671 UBE2V1 ubiquitin conjugating enzyme E2 V1 2 2
MIRT465432 TP53 tumor protein p53 2 2
MIRT465934 TMEM189-UBE2V1 TMEM189-UBE2V1 readthrough 2 2
MIRT466015 TMEM189 transmembrane protein 189 2 2
MIRT468122 SH3PXD2A SH3 and PX domains 2A 2 2
MIRT469652 RAC1 Rac family small GTPase 1 2 2
MIRT469980 PTPN14 protein tyrosine phosphatase, non-receptor type 14 2 2
MIRT473531 MAX MYC associated factor X 2 2
MIRT473596 MARK2 microtubule affinity regulating kinase 2 2 2
MIRT473652 MARCKSL1 MARCKS like 1 2 2
MIRT474219 LCOR ligand dependent nuclear receptor corepressor 2 4
MIRT474771 KIAA0895L KIAA0895 like 2 2
MIRT479312 VPS72 vacuolar protein sorting 72 homolog 2 2
MIRT481121 AZIN1 antizyme inhibitor 1 2 4
MIRT481682 AR androgen receptor 2 2
MIRT482381 AEN apoptosis enhancing nuclease 2 2
MIRT483833 UNC5B unc-5 netrin receptor B 2 4
MIRT484693 RNF11 ring finger protein 11 2 2
MIRT485238 POGZ pogo transposable element derived with ZNF domain 2 2
MIRT488748 FXYD1 FXYD domain containing ion transport regulator 1 2 2
MIRT489147 MRPL12 mitochondrial ribosomal protein L12 2 4
MIRT489518 MRE11A MRE11 homolog, double strand break repair nuclease 2 8
MIRT498908 SRCAP Snf2 related CREBBP activator protein 2 2
MIRT506426 NAGK N-acetylglucosamine kinase 2 6
MIRT506640 MAPK1 mitogen-activated protein kinase 1 2 4
MIRT507332 FAM168A family with sequence similarity 168 member A 2 2
MIRT513099 DYNAP dynactin associated protein 2 2
MIRT513514 YIPF4 Yip1 domain family member 4 2 6
MIRT521800 POM121C POM121 transmembrane nucleoporin C 2 2
MIRT525078 FRK fyn related Src family tyrosine kinase 2 2
MIRT530927 SCIN scinderin 2 2
MIRT533498 TRIM71 tripartite motif containing 71 2 2
MIRT536787 HNRNPD heterogeneous nuclear ribonucleoprotein D 2 2
MIRT544554 CSNK2A1 casein kinase 2 alpha 1 2 2
MIRT552977 VAT1 vesicle amine transport 1 2 2
MIRT557358 HAND1 heart and neural crest derivatives expressed 1 2 2
MIRT560401 TMEM69 transmembrane protein 69 2 2
MIRT565498 SP1 Sp1 transcription factor 2 2
MIRT568962 CACNA1C calcium voltage-gated channel subunit alpha1 C 2 2
MIRT569031 IL21R interleukin 21 receptor 2 2
MIRT573224 TRIM21 tripartite motif containing 21 2 2
MIRT574312 ZNF703 zinc finger protein 703 2 2
MIRT620395 MYO1H myosin IH 2 2
MIRT620936 OSMR oncostatin M receptor 2 2
MIRT638166 TMED4 transmembrane p24 trafficking protein 4 2 2
MIRT647743 SAMD9L sterile alpha motif domain containing 9 like 2 2
MIRT649991 MSI1 musashi RNA binding protein 1 2 2
MIRT669203 CBX8 chromobox 8 2 2
MIRT684546 ZNF708 zinc finger protein 708 2 2
MIRT685837 ANGEL1 angel homolog 1 2 2
MIRT688547 DCAF16 DDB1 and CUL4 associated factor 16 2 2
MIRT693252 HBS1L HBS1 like translational GTPase 2 2
MIRT701970 MIER3 MIER family member 3 2 2
MIRT706385 MC2R melanocortin 2 receptor 2 2
MIRT707484 UGT2B4 UDP glucuronosyltransferase family 2 member B4 2 2
MIRT711882 INSIG2 insulin induced gene 2 2 2
MIRT716906 CACNB2 calcium voltage-gated channel auxiliary subunit beta 2 2 2
MIRT717638 HLX H2.0 like homeobox 2 2
MIRT719058 ZNF281 zinc finger protein 281 2 2
MIRT723754 NKIRAS2 NFKB inhibitor interacting Ras like 2 2 2
MIRT725479 GPR26 G protein-coupled receptor 26 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-2110 Cisplatin 5460033 NSC119875 approved resistant High Gastric Cancer cell line (SGC-7901)
hsa-miR-2110 Cisplatin 5460033 NSC119875 approved sensitive Low Cervical Cancer tissue
hsa-miR-2110 Gemcitabine 60750 NSC613327 approved resistant High Pancreatic Cancer cell line (AsPC-1)
hsa-mir-2110 Dabrafenib 44462760 NSC764134 approved resistant cell line (A375)
hsa-mir-2110 Paclitaxel 36314 NSC125973 approved sensitive cell line (W1)
hsa-mir-2110 Cisplatin 5460033 NSC119875 approved sensitive cell line (W1)
hsa-mir-2110 Methotrexate 126941 NSC740 approved sensitive cell line (W1)
hsa-mir-2110 Vincristine 5978 approved sensitive cell line (W1)
hsa-mir-2110 Topotecan 60699 NSC609699 approved sensitive cell line (W1)
hsa-mir-2110 Paclitaxel 36314 NSC125973 approved resistant cell line (A2780)
hsa-mir-2110 Androstenedione 6128 NSC9563 sensitive cell line (MCF-7)
hsa-mir-2110 Androstenedione+Letrozole sensitive cell line (MCF-7)
hsa-mir-2110 Ceritinib 57379345 NSC776422 approved resistant cell line (H3122)
hsa-mir-2110 Cisplatin 5460033 NSC119875 approved resistant cell line (SGC-7901)
hsa-miR-2110 Osimertinib 71496458 NSC779217 approved resistant cell line (PC9)
hsa-miR-2110 Osimertinib 71496458 NSC779217 approved sensitive cell line (HCC827)
hsa-miR-2110 Cisplatin 5460033 NSC119875 approved resistant cell line
hsa-miR-2110 Paclitaxel 36314 NSC125973 approved sensitive cell line (BAS)
hsa-miR-2110 Cisplatin 5460033 NSC119875 approved resistant cell line (A549)
hsa-miR-2110 Tamoxifen 2733525 NSC180973 approved resistant cell line (LCC2)
hsa-miR-2110 Tamoxifen+Fulvestrant resistant cell line (LCC9)
hsa-miR-2110 Paclitaxel 36314 NSC125973 approved resistant cell line (A2780)
hsa-miR-2110 Cisplatin 5460033 NSC119875 approved resistant cell line (MGC-803)
hsa-miR-2110 Pegylated interferon alpha+Ribavirin sensitive tissue (chronic hepatitis C)
hsa-miR-2110 Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-2110 Gemcitabine 60750 NSC613327 approved sensitive cell line (PANC-1) (1500 ng/ml)
hsa-miR-2110 Cisplatin 5460033 NSC119875 approved resistant cell line (TOV-112D)
hsa-miR-2110 Cisplatin 5460033 NSC119875 approved resistant cell line (OVSAHO)

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