miRTarBase - #MIRT455764


—
pre-miRNA Information
pre-miRNA hsa-mir-4666a   
Genomic Coordinates chr1: 228462074 - 228462152
Description Homo sapiens miR-4666a stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-4666a-5p
Sequence 10| AUACAUGUCAGAUUGUAUGCC |30
Evidence Experimental
Experiments Illumina
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1288210208 3 dbSNP
rs1333314792 5 dbSNP
rs562096649 7 dbSNP
rs1324809033 10 dbSNP
rs1027635037 13 dbSNP
rs1351630778 15 dbSNP
rs1034879562 18 dbSNP
rs1383267208 21 dbSNP
Putative Targets

Gene Information
Gene Symbol TSPAN6   
Synonyms T245, TM4SF6, TSPAN-6
Description tetraspanin 6
Transcript NM_003270   
Expression
Putative miRNA Targets on TSPAN6
3'UTR of TSPAN6
(miRNA target sites are highlighted)		 
>TSPAN6|NM_003270|3'UTR
   1 CCCAATGTATCTGTGGGCCTATTCCTCTCTACCTTTAAGGACATTTAGGGTCCCCCCTGTGAATTAGAAAGTTGCTTGGC
  81 TGGAGAACTGACAACACTACTTACTGATAGACCAAAAAACTACACCAGTAGGTTGATTCAATCAAGATGTATGTAGACCT
 161 AAAACTACACCAATAGGCTGATTCAATCAAGATCCGTGCTCGCAGTGGGCTGATTCAATCAAGATGTATGTTTGCTATGT
 241 TCTAAGTCCACCTTCTATCCCATTCATGTTAGATCGTTGAAACCCTGTATCCCTCTGAAACACTGGAAGAGCTAGTAAAT
 321 TGTAAATGAAGTAATACTGTGTTCCTCTTGACTGTTATTTTTCTTAGTAGGGGGCCTTTGGAAGGCACTGTGAATTTGCT
 401 ATTTTGATGTAGTGTTACAAGATGGAAAATTGATTCCTCTGACTTTGCTATTGATGTAGTGTGATAGAAAATTCACCCCT
 481 CTGAACTGGCTCCTTCCCAGTCAAGGTTATCTGGTTTGATTGTATAATTTGCACCAAGAAGTTAAAATGTTTTATGACTC
 561 TCTGTTCTGCTGACAGGCAGAGAGTCACATTGTGTAATTTAATTTCAGTCAGTCAATAGATGGCATCCCTCATCAGGGTT
 641 GCCAGATGGTGATAACAGTGTAAGGCCTTGGGTCTAAGGCATCCACGACTGGAAGGGACTACTGATGTTCTGTGATACAT
 721 CAGGTTTCAGCACACAACTTACATTTCTTTGCCTCCAAATTGAGGCATTTATTATGATGTTCATACTTTCCCTCTTGTTT
 801 GAAAGTTTCTAATTATTAAATGGTGTCGGAATTGTTGTATTTTCCTTAGGAATTCAGTGGAACTTATCTTCATTAAATTT
 881 AGCTGGTACCAGGTTGATATGACTTGTCAATATTATGGTCAACTTTAAGTCTTAGTTTTCGTTTGTGCCTTTGATTAATA
 961 AGTATAACTCTTATACAATAAATACTGCTTTCCTCTAAAAAGATCGTGTTTAAATTAACTTGTAGAAAATCTGCTGGAAT
1041 GGTTGTTGTTTTCCACTGAGAAAGCTAAGCCCTACATTTCTATTCAGAGTACTGTTTTTAGATGTGAAATATAAGCCTGC
1121 GGCCTTAACTCTGTATTAAAAAAAATGTTTTTGTTTAAAAAAAACTGTTCCCATAGGTGCAGCAAACCACCATGGCACAT
1201 GTATACCTATGTAACAAACCTGCACATTCTGCACATGTATCCCAGAACTTAATGTAAACAAAAAAATCTTAAAGTGCAAA
1281 TATTAAAAAAAACTGTTCTCTGTGAAAAAAATTATATTCCATGTTATAAAGTAGCATATGACTAGTGTTCTCCTAGAGAT
1361 CAGACTTTTTTGATTGTATAGTTTGCATTAAAAAGTTGTACAGGGAGGGATGTAACCTGTATCTTCAGGATAATAGGGAA
1441 ATTAATAAGGAAAATAATAATTACTAAAATTTGAGTTGAAGTCAGGGAATTATTTCTTTGGTTTTGAGTCTCTTTATACA
1521 TCCATTAGTAGAACCTGTCTAGTCTGATTGCCACAGTCCTTGAATTGATGGTAAGGGGGAGTCAGTTACAGTTAGAAAAA
1601 AACCTGGGCAAAAACTACTAGTTAAATGATCATGAATTTTGAGTATGTGTTTTAAAATGCTTGGAGTTATTGCAGAAAAA
1681 TGATATTCTCCATTAGAACATTTGATGTGTGACTTTTGACATAGGATAAGGTGATAAGAAAATTAAGTTGAAAAATAGTG
1761 ACTCAAGTACAGCAAATCAGATTTTTGGCTACTGAGATTAAAGAAGCAAATATTTAAAGGATTATCAGCAATTTTCAAAT
1841 ACATATTTTTCACTGCAGTGGTTTTGAAGAATGTTTTAAGGTTATATTTAGAGTTTTTAAAAAAGTTTTCCCTCAGCCAG
1921 CCATGGTGGCTCACATCTGTAATCCCAGCACTTTGAGAGGCTGAGGCGGGCGGATCACCTGAGGTCAGGAGTTCTAGACC
2001 AGCCTGGCCAACATGGTAAAACACCGTCTCTAATAAAAATGCAAAAATTAGCTGGGTGTGGTGGCAAGCACCTGTAATCC
2081 CAGCTACTTGGGAGACTGAGGCAGGAGAATCACTTGAATCCAGGAGTCAGAGGTTGCAGTGAGCCGAGATCACACCACTG
2161 CACTCCAGCCTGGGCGATAAGAGTGAACCTGCATCTCAGAAAAAAAAAAAAAGTTTTCCCTCATTATTAAAAAGGAAAAA
2241 TTATAGAAAATTAAAATATAGAATGTAGAAAGAGGAAAAACACCACACATCACTCGTCAGGTGGATTGGTTTGTTTATTT
2321 TTAAGATGGGTTTATTTTGGATAGCCAGTTAGAAAACGCCCTTATAGCTGATGTGTGCTTGTGCATACTGAATTGTATAC
2401 TTAATTCTGAAAGTAATGAGGAAACATTTCACCTAATGATAACTGGTACAAAGGAAAGTTCACGTGTCTTTAATAGTTTG
2481 CTAATTAGACTAGCTGGTTAGAAAGAGGGATCACTAGATTGGAGAGAGAGATCCAGTTTCCACTGGAGGCAGTAGGTCTG
2561 CTCATTTCCATGGTGACAATCCTAATGGCAGAGGGAGTGAGTTTCCCTTAGTGGCACAGGCTGGGGGTTTTGAGCTTTTA
2641 AGTTTTGTTTTATAGAAATCTGGAGAATTTTACATTTTACTTCACTATATATCTATGTTTAAAATAATTCATTTTTGATG
2721 TCCCAAAATTGATGTGGGTTGCCTTATTTCCAGGCACCAGGTTGCTCACTGCAAGGTGACATTTTGAGAAGCAGAAATCT
2801 CTAGGTATATCTTAAGTGTGAAAAGCTTGTTAGATTTCCATGGCCTATTCCAGGTGGGTTGTTGGGTTTATGTTGTAAGC
2881 ATCAAACTTTTGTGGAAATAAATACCTAATACAAGGTAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' ccguaUGUUAGAC-UGUACAUa 5'
               ||| |||| ||||||| 
Target 5' cctgcACATTCTGCACATGTAt 3'
 1219 - 1240 164.00 -14.40
2 
miRNA  3' ccGUAUGUUAG-AC--UGUACAUa 5'
            || || | | ||  ||||||| 
Target 5' agCAAACCACCATGGCACATGTAt 3'
 1181 - 1204 153.00 -9.90
3 
miRNA  3' ccgUAUGUUAGACUGUACAUa 5'
             || |||||  | ||||| 
Target 5' ttgATTCAATC-AAGATGTAt 3'
 133 - 152 129.00 -7.40
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1194140318 1 dbSNP
rs1467870769 3 dbSNP
rs745988464 4 dbSNP
rs773230258 9 dbSNP
rs772323091 13 dbSNP
rs1309452948 19 dbSNP
rs762067864 21 dbSNP
rs774718611 26 dbSNP
rs370864101 29 dbSNP
rs1440874256 33 dbSNP
rs780011498 43 dbSNP
rs769688424 48 dbSNP
rs377566575 66 dbSNP
rs1362113932 68 dbSNP
rs1226625694 75 dbSNP
rs781683511 92 dbSNP
rs1306503477 102 dbSNP
rs887450288 129 dbSNP
rs1274770297 136 dbSNP
rs1332366937 142 dbSNP
rs892775647 144 dbSNP
rs2234094 152 dbSNP
rs993433904 154 dbSNP
rs1184788868 172 dbSNP
rs749573367 175 dbSNP
rs751966721 186 dbSNP
rs1040198668 187 dbSNP
rs944576842 196 dbSNP
rs889167544 198 dbSNP
rs780362592 200 dbSNP
rs1167335271 206 dbSNP
rs1221298691 207 dbSNP
rs1365857452 208 dbSNP
rs777971302 210 dbSNP
rs889300143 225 dbSNP
rs1347399493 234 dbSNP
rs1454908836 239 dbSNP
rs1050476096 243 dbSNP
rs946688169 244 dbSNP
rs898097788 280 dbSNP
rs1435258688 281 dbSNP
rs1388871819 283 dbSNP
rs1036584911 285 dbSNP
rs1322025818 287 dbSNP
rs1455172072 289 dbSNP
rs915259442 293 dbSNP
rs942028337 307 dbSNP
rs909173543 309 dbSNP
rs1260262111 315 dbSNP
rs1190405950 324 dbSNP
rs1255663091 329 dbSNP
rs7885645 342 dbSNP
rs756478727 347 dbSNP
rs1475089995 353 dbSNP
rs7884655 357 dbSNP
rs1410833833 362 dbSNP
rs1399426071 374 dbSNP
rs1176632938 380 dbSNP
rs111895914 382 dbSNP
rs982302628 384 dbSNP
rs1314398496 391 dbSNP
rs1422756381 392 dbSNP
rs1413953955 394 dbSNP
rs1190381022 397 dbSNP
rs969965004 398 dbSNP
rs1022687140 403 dbSNP
rs755400300 428 dbSNP
rs1306189555 432 dbSNP
rs113751553 450 dbSNP
rs765318051 456 dbSNP
rs928734025 459 dbSNP
rs761956354 461 dbSNP
rs1278476796 466 dbSNP
rs1485441890 471 dbSNP
rs1206357743 481 dbSNP
rs1027305880 483 dbSNP
rs113955254 497 dbSNP
rs1464445259 506 dbSNP
rs149308632 509 dbSNP
rs1212796844 514 dbSNP
rs1177189553 517 dbSNP
rs1426474453 519 dbSNP
rs1454335655 521 dbSNP
rs1019281685 522 dbSNP
rs141932480 536 dbSNP
rs981707424 540 dbSNP
rs1433671203 542 dbSNP
rs1301059333 550 dbSNP
rs756822635 551 dbSNP
rs1050444801 559 dbSNP
rs1297543519 563 dbSNP
rs946783026 566 dbSNP
rs1236620856 572 dbSNP
rs1301291904 576 dbSNP
rs1347206409 586 dbSNP
rs1215427278 591 dbSNP
rs111805105 594 dbSNP
rs967223883 596 dbSNP
rs1204179674 598 dbSNP
rs1052380049 608 dbSNP
rs1470182164 609 dbSNP
rs935372257 613 dbSNP
rs190968005 623 dbSNP
rs928201176 633 dbSNP
rs982780330 635 dbSNP
rs112565286 649 dbSNP
rs1006551577 659 dbSNP
rs1303395173 663 dbSNP
rs916770203 671 dbSNP
rs1467562176 689 dbSNP
rs1421118495 698 dbSNP
rs1357337711 708 dbSNP
rs1169426373 709 dbSNP
rs1395173728 727 dbSNP
rs890892374 728 dbSNP
rs1175167257 729 dbSNP
rs984312724 764 dbSNP
rs1370413907 775 dbSNP
rs1431560208 776 dbSNP
rs1029399797 787 dbSNP
rs186111476 813 dbSNP
rs182031813 825 dbSNP
rs1214372705 828 dbSNP
rs1274153107 860 dbSNP
rs1064003 866 dbSNP
rs1186846027 867 dbSNP
rs1027443966 869 dbSNP
rs1212432849 878 dbSNP
rs759172676 886 dbSNP
rs1252919656 887 dbSNP
rs753543353 892 dbSNP
rs1193202805 901 dbSNP
rs1243514456 902 dbSNP
rs971717743 907 dbSNP
rs1185542883 911 dbSNP
rs1448961280 921 dbSNP
rs1462805202 926 dbSNP
rs12151 932 dbSNP
rs1393550355 934 dbSNP
rs371001313 936 dbSNP
rs1018832029 940 dbSNP
rs770427652 941 dbSNP
rs1324938962 942 dbSNP
rs889053970 946 dbSNP
rs143808656 958 dbSNP
rs1357832000 963 dbSNP
rs942225925 963 dbSNP
rs551142904 965 dbSNP
rs8575 967 dbSNP
rs769188061 968 dbSNP
rs191134285 973 dbSNP
rs1055843204 974 dbSNP
rs1052954449 975 dbSNP
rs937340876 976 dbSNP
rs375780974 977 dbSNP
rs999501170 987 dbSNP
rs1185454269 988 dbSNP
rs906540829 994 dbSNP
rs111679688 1000 dbSNP
rs1046620071 1009 dbSNP
rs981520755 1027 dbSNP
rs945889442 1029 dbSNP
rs948288068 1030 dbSNP
rs780452501 1034 dbSNP
rs916864969 1040 dbSNP
rs1313720741 1047 dbSNP
rs1225684063 1048 dbSNP
rs1325459127 1059 dbSNP
rs1054701 1061 dbSNP
rs138817409 1064 dbSNP
rs1293023833 1067 dbSNP
rs931470557 1071 dbSNP
rs1376973202 1088 dbSNP
rs1314379981 1094 dbSNP
rs990035869 1095 dbSNP
rs1430179647 1104 dbSNP
rs1278285206 1105 dbSNP
rs957320096 1127 dbSNP
rs767309418 1130 dbSNP
rs1280613316 1142 dbSNP
rs1486418831 1143 dbSNP
rs972236848 1145 dbSNP
rs1208503236 1163 dbSNP
rs1255262836 1171 dbSNP
rs759436947 1173 dbSNP
rs201139368 1185 dbSNP
rs1429394152 1194 dbSNP
rs1369244659 1195 dbSNP
rs961709986 1201 dbSNP
rs1167071111 1215 dbSNP
rs533172435 1218 dbSNP
rs955038186 1219 dbSNP
rs1439179220 1228 dbSNP
rs1174290268 1236 dbSNP
rs1256070545 1240 dbSNP
rs1183476473 1259 dbSNP
rs1397151037 1266 dbSNP
rs185936565 1273 dbSNP
rs1250120974 1274 dbSNP
rs1204865170 1305 dbSNP
rs1338411494 1308 dbSNP
rs1265660118 1310 dbSNP
rs1393501418 1315 dbSNP
rs1246358911 1321 dbSNP
rs1335625317 1324 dbSNP
rs1319344710 1330 dbSNP
rs1238817152 1332 dbSNP
rs1303448920 1336 dbSNP
rs779226987 1341 dbSNP
rs771069042 1346 dbSNP
rs1410314435 1356 dbSNP
rs993891857 1357 dbSNP
rs953287311 1358 dbSNP
rs1028907554 1382 dbSNP
rs1197274088 1388 dbSNP
rs1248358473 1398 dbSNP
rs1390587021 1408 dbSNP
rs1010658025 1413 dbSNP
rs1194155189 1424 dbSNP
rs1255019976 1435 dbSNP
rs1452648981 1451 dbSNP
rs1391805565 1452 dbSNP
rs150258792 1458 dbSNP
rs1463861867 1460 dbSNP
rs754021809 1461 dbSNP
rs1054594 1462 dbSNP
rs1000035902 1468 dbSNP
rs749302047 1479 dbSNP
rs1015134848 1486 dbSNP
rs1159966176 1488 dbSNP
rs1473888692 1491 dbSNP
rs906643309 1493 dbSNP
rs1046817496 1503 dbSNP
rs1300183598 1505 dbSNP
rs1307669639 1509 dbSNP
rs12318 1511 dbSNP
rs1006391200 1540 dbSNP
rs1249446839 1542 dbSNP
rs888053335 1551 dbSNP
rs1410383921 1567 dbSNP
rs1012292494 1569 dbSNP
rs895359854 1583 dbSNP
rs1452487142 1592 dbSNP
rs1267630099 1599 dbSNP
rs141096119 1601 dbSNP
rs1190624982 1611 dbSNP
rs1487236268 1611 dbSNP
rs112075334 1629 dbSNP
rs756176724 1639 dbSNP
rs1331208431 1655 dbSNP
rs907179137 1660 dbSNP
rs1423412627 1661 dbSNP
rs1462282867 1689 dbSNP
rs1286370522 1699 dbSNP
rs1046237183 1711 dbSNP
rs1455953970 1712 dbSNP
rs946102279 1713 dbSNP
rs913313788 1736 dbSNP
rs1054258181 1740 dbSNP
rs1037222822 1750 dbSNP
rs1339674411 1756 dbSNP
rs1233608421 1757 dbSNP
rs1325814426 1759 dbSNP
rs911148856 1769 dbSNP
rs1332521902 1777 dbSNP
rs181408156 1778 dbSNP
rs773438572 1782 dbSNP
rs1261426271 1786 dbSNP
rs1486876483 1794 dbSNP
rs1203670251 1795 dbSNP
rs955215228 1801 dbSNP
rs911677872 1802 dbSNP
rs1458884282 1807 dbSNP
rs987541714 1816 dbSNP
rs1190455948 1820 dbSNP
rs752674834 1823 dbSNP
rs370488845 1833 dbSNP
rs922257814 1846 dbSNP
rs1160442178 1858 dbSNP
rs1345332436 1892 dbSNP
rs1454892682 1898 dbSNP
rs1295973074 1903 dbSNP
rs1359442077 1905 dbSNP
rs953053144 1912 dbSNP
rs1478575120 1918 dbSNP
rs972800600 1919 dbSNP
rs1294853247 1929 dbSNP
rs921820632 1936 dbSNP
rs1227720116 1937 dbSNP
rs989372485 1944 dbSNP
rs1318880946 1945 dbSNP
rs961155774 1947 dbSNP
rs957843429 1960 dbSNP
rs1197159401 1965 dbSNP
rs1370361346 1971 dbSNP
rs1031233877 1972 dbSNP
rs767492786 1981 dbSNP
rs999396426 1982 dbSNP
rs971213051 1985 dbSNP
rs1285606952 1998 dbSNP
rs1486098940 2007 dbSNP
rs1025060032 2012 dbSNP
rs1213250176 2013 dbSNP
rs1012219050 2025 dbSNP
rs1016674912 2038 dbSNP
rs1006424109 2039 dbSNP
rs1431142198 2039 dbSNP
rs952161907 2045 dbSNP
rs1410718454 2046 dbSNP
rs895161917 2048 dbSNP
rs1156247808 2055 dbSNP
rs1001755243 2064 dbSNP
rs1266177487 2065 dbSNP
rs907206788 2073 dbSNP
rs1314305830 2074 dbSNP
rs79521063 2076 dbSNP
rs1045767443 2081 dbSNP
rs1447008378 2084 dbSNP
rs1345595950 2094 dbSNP
rs1276451724 2098 dbSNP
rs1375367377 2099 dbSNP
rs1010193103 2100 dbSNP
rs1308672002 2105 dbSNP
rs1348658493 2114 dbSNP
rs769956607 2122 dbSNP
rs1276768544 2124 dbSNP
rs1370617873 2127 dbSNP
rs1054438830 2136 dbSNP
rs995737957 2137 dbSNP
rs911016246 2139 dbSNP
rs143753866 2140 dbSNP
rs1178529346 2144 dbSNP
rs1386483319 2147 dbSNP
rs112798431 2150 dbSNP
rs141778748 2156 dbSNP
rs1454320613 2159 dbSNP
rs933957241 2170 dbSNP
rs1422538235 2176 dbSNP
rs1413712852 2179 dbSNP
rs1170833512 2182 dbSNP
rs1356030922 2187 dbSNP
rs188496625 2195 dbSNP
rs1444537601 2200 dbSNP
rs1330579220 2201 dbSNP
rs1371906448 2207 dbSNP
rs147790856 2212 dbSNP
rs1273315490 2217 dbSNP
rs1367118259 2240 dbSNP
rs1215551618 2245 dbSNP
rs772770403 2254 dbSNP
rs1171250833 2262 dbSNP
rs1275595548 2272 dbSNP
rs1316420938 2279 dbSNP
rs1198631984 2282 dbSNP
rs1051469272 2288 dbSNP
rs1274348503 2291 dbSNP
rs1468541985 2300 dbSNP
rs931623845 2306 dbSNP
rs1434478588 2316 dbSNP
rs921622864 2326 dbSNP
rs1477515166 2348 dbSNP
rs748578638 2362 dbSNP
rs1421465527 2387 dbSNP
rs936579864 2389 dbSNP
rs1169882374 2395 dbSNP
rs781450110 2395 dbSNP
rs1463103608 2398 dbSNP
rs1321630800 2401 dbSNP
rs1349338546 2406 dbSNP
rs1431807190 2423 dbSNP
rs113347545 2438 dbSNP
rs972449715 2452 dbSNP
rs1338992427 2455 dbSNP
rs1450814742 2460 dbSNP
rs1245715222 2476 dbSNP
rs939655303 2500 dbSNP
rs909646224 2503 dbSNP
rs970593625 2506 dbSNP
rs747592110 2519 dbSNP
rs1287190390 2520 dbSNP
rs983849590 2526 dbSNP
rs1191821798 2528 dbSNP
rs1216150269 2542 dbSNP
rs1264802168 2574 dbSNP
rs1476727755 2575 dbSNP
rs775990938 2581 dbSNP
rs1280650146 2593 dbSNP
rs1476167416 2600 dbSNP
rs1025450982 2603 dbSNP
rs1198520405 2612 dbSNP
rs1161365317 2614 dbSNP
rs1346810638 2625 dbSNP
rs755347981 2641 dbSNP
rs1401352232 2644 dbSNP
rs990920920 2651 dbSNP
rs747535509 2652 dbSNP
rs184619952 2673 dbSNP
rs1358793272 2677 dbSNP
rs1034491352 2680 dbSNP
rs959465301 2689 dbSNP
rs1313827257 2692 dbSNP
rs1357736283 2695 dbSNP
rs1284122579 2701 dbSNP
rs1355047968 2707 dbSNP
rs1026971783 2715 dbSNP
rs1275652082 2725 dbSNP
rs1287748714 2727 dbSNP
rs995539341 2732 dbSNP
rs1363249953 2737 dbSNP
rs181492749 2739 dbSNP
rs1443913024 2740 dbSNP
rs1015850652 2743 dbSNP
rs1185411612 2744 dbSNP
rs1008779503 2745 dbSNP
rs971714647 2756 dbSNP
rs1448830447 2765 dbSNP
rs891310005 2766 dbSNP
rs1024962507 2773 dbSNP
rs1160482061 2776 dbSNP
rs1051439420 2778 dbSNP
rs931715345 2784 dbSNP
rs78209879 2793 dbSNP
rs1377717970 2797 dbSNP
rs1053378523 2798 dbSNP
rs1336816839 2802 dbSNP
rs1033058653 2816 dbSNP
rs936391062 2819 dbSNP
rs923818913 2821 dbSNP
rs1239060423 2823 dbSNP
rs1000201757 2836 dbSNP
rs1198459292 2840 dbSNP
rs978046993 2857 dbSNP
rs1438285334 2867 dbSNP
rs1180400079 2874 dbSNP
rs780640830 2893 dbSNP
rs1439159476 2896 dbSNP
rs949217259 2901 dbSNP
rs1379527907 2911 dbSNP
rs1472802522 2913 dbSNP
rs1239147699 2918 dbSNP
rs554507947 2920 dbSNP
rs1049620497 2925 dbSNP
rs917740010 2930 dbSNP
rs990678521 2935 dbSNP
rs1485241478 2947 dbSNP
rs901117872 2953 dbSNP
rs1252321833 2962 dbSNP
rs1374107403 2963 dbSNP
rs1207005624 2967 dbSNP
rs1340375363 2968 dbSNP
rs1272556706 2969 dbSNP
rs1228964520 2971 dbSNP
rs959434652 2972 dbSNP
rs1027109077 2980 dbSNP
rs1282963751 2981 dbSNP
rs1255235827 2985 dbSNP
rs1339815485 2985 dbSNP
rs35302106 2985 dbSNP
rs1233165613 2986 dbSNP
rs1457378297 2990 dbSNP
rs1194283691 2992 dbSNP
rs756839271 2995 dbSNP
rs1310304236 2996 dbSNP
rs757546887 2996 dbSNP
rs961410603 3001 dbSNP
rs909510486 3008 dbSNP
rs1016233962 3025 dbSNP
rs1008500425 3036 dbSNP
rs140258667 3049 dbSNP
rs1028434776 3052 dbSNP
rs1400136710 3057 dbSNP
rs937811972 3065 dbSNP
rs1405470470 3067 dbSNP
rs1473196175 3068 dbSNP
rs997005470 3071 dbSNP
rs900260007 3080 dbSNP
rs1300160253 3083 dbSNP
rs1326808658 3086 dbSNP
rs778063494 3089 dbSNP
rs1474866463 3101 dbSNP
rs1053474455 3102 dbSNP
rs756264601 3110 dbSNP
rs1317179596 3123 dbSNP
rs1214209261 3129 dbSNP
rs971961939 3130 dbSNP
rs1184153562 3135 dbSNP
rs1479495160 3138 dbSNP
rs1209543530 3139 dbSNP
rs1232533950 3145 dbSNP
rs1000909706 3160 dbSNP
rs1222520235 3180 dbSNP
rs902194443 3187 dbSNP
rs1042470308 3198 dbSNP
rs1475844314 3203 dbSNP
rs1167501664 3205 dbSNP
rs1369754564 3208 dbSNP
rs1455874029 3210 dbSNP
rs1292595020 3233 dbSNP
rs1360711268 3236 dbSNP
rs1204397 3252 dbSNP
rs1296155776 3266 dbSNP
rs1339568046 3274 dbSNP
rs917872738 3280 dbSNP
rs1228872829 3282 dbSNP
rs1232738892 3290 dbSNP
rs1314770885 3297 dbSNP
rs1054960999 3301 dbSNP
rs1290682559 3302 dbSNP
rs763867975 3308 dbSNP
rs1489371745 3312 dbSNP
rs767507984 3313 dbSNP
rs375581241 3316 dbSNP
rs1372997114 3324 dbSNP
rs1262981720 3326 dbSNP
rs919976226 3328 dbSNP
rs1278626695 3335 dbSNP
rs1254618373 3337 dbSNP
rs1421564801 3350 dbSNP
rs1436806666 3357 dbSNP
rs1380341595 3370 dbSNP
rs974199301 3377 dbSNP
rs1156440996 3381 dbSNP
rs754844922 3392 dbSNP
rs961654705 3394 dbSNP
rs761489788 3412 dbSNP
rs1323373904 3424 dbSNP
rs755759807 3425 dbSNP
rs1460459745 3432 dbSNP
rs1389287593 3456 dbSNP
rs987235247 3457 dbSNP
rs889900957 3459 dbSNP
rs1395560015 3461 dbSNP
rs955642840 3465 dbSNP
rs1028572143 3467 dbSNP
rs998042387 3479 dbSNP
rs1238320854 3497 dbSNP
rs1285575534 3498 dbSNP
rs900977750 3510 dbSNP
rs1417105462 3518 dbSNP
rs1036954146 3523 dbSNP
rs1483230193 3537 dbSNP
rs185032432 3555 dbSNP
rs1238315531 3563 dbSNP
rs1440991169 3571 dbSNP
rs1191522489 3572 dbSNP
rs888359341 3579 dbSNP
rs1479163058 3583 dbSNP
rs1414849841 3586 dbSNP
rs1177923146 3587 dbSNP
rs1048130518 3588 dbSNP
rs1357182734 3588 dbSNP
rs78444289 3592 dbSNP
rs1204396 3596 dbSNP
rs1379298117 3598 dbSNP
rs937658655 3609 dbSNP
rs1032028020 3612 dbSNP
rs1000602171 3629 dbSNP
rs1368521976 3645 dbSNP
rs1213148725 3662 dbSNP
rs902289658 3668 dbSNP
rs1277006170 3682 dbSNP
rs767269286 3691 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Disease 7105.0
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... "PAR-CLIP data was present in GSM1065667. RNA binding protein: AGO1. Condition:4-thiouridine ...

- Memczak S; Jens M; Elefsinioti A; Torti F; et al., 2013, Nature.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' ccguaUGUUAGAC-UGUACaua 5'
               ||| |||| |||||   
Target 5' ccugcACAUUCUGCACAUG--- 3'
 		18 - 36
Article - Memczak S; Jens M; Elefsinioti A; Torti F; et al.
- Nature, 2013
Circular RNAs (circRNAs) in animals are an enigmatic class of RNA with unknown function. To explore circRNAs systematically, we sequenced and computationally analysed human, mouse and nematode RNA. We detected thousands of well-expressed, stable circRNAs, often showing tissue/developmental-stage-specific expression. Sequence analysis indicated important regulatory functions for circRNAs. We found that a human circRNA, antisense to the cerebellar degeneration-related protein 1 transcript (CDR1as), is densely bound by microRNA (miRNA) effector complexes and harbours 63 conserved binding sites for the ancient miRNA miR-7. Further analyses indicated that CDR1as functions to bind miR-7 in neuronal tissues. Human CDR1as expression in zebrafish impaired midbrain development, similar to knocking down miR-7, suggesting that CDR1as is a miRNA antagonist with a miRNA-binding capacity ten times higher than any other known transcript. Together, our data provide evidence that circRNAs form a large class of post-transcriptional regulators. Numerous circRNAs form by head-to-tail splicing of exons, suggesting previously unrecognized regulatory potential of coding sequences.
LinkOut: [PMID: 23446348]
Experimental Support 2 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions TZM-bl
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM1462574. RNA binding protein: AGO2. Condition:TZM-bl ami BaL ...

- Whisnant AW; Bogerd HP; Flores O; Ho P; et al., 2013, mBio.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' ccguaUGUUAGAC-UGUACaua 5'
               ||| |||| |||||   
Target 5' ccugcACAUUCUGCACAUG--- 3'
 		17 - 35
Article - Whisnant AW; Bogerd HP; Flores O; Ho P; et al.
- mBio, 2013
UNLABELLED: The question of how HIV-1 interfaces with cellular microRNA (miRNA) biogenesis and effector mechanisms has been highly controversial. Here, we first used deep sequencing of small RNAs present in two different infected cell lines (TZM-bl and C8166) and two types of primary human cells (CD4(+) peripheral blood mononuclear cells [PBMCs] and macrophages) to unequivocally demonstrate that HIV-1 does not encode any viral miRNAs. Perhaps surprisingly, we also observed that infection of T cells by HIV-1 has only a modest effect on the expression of cellular miRNAs at early times after infection. Comprehensive analysis of miRNA binding to the HIV-1 genome using the photoactivatable ribonucleoside-induced cross-linking and immunoprecipitation (PAR-CLIP) technique revealed several binding sites for cellular miRNAs, a subset of which were shown to be capable of mediating miRNA-mediated repression of gene expression. However, the main finding from this analysis is that HIV-1 transcripts are largely refractory to miRNA binding, most probably due to extensive viral RNA secondary structure. Together, these data demonstrate that HIV-1 neither encodes viral miRNAs nor strongly influences cellular miRNA expression, at least early after infection, and imply that HIV-1 transcripts have evolved to avoid inhibition by preexisting cellular miRNAs by adopting extensive RNA secondary structures that occlude most potential miRNA binding sites. IMPORTANCE: MicroRNAs (miRNAs) are a ubiquitous class of small regulatory RNAs that serve as posttranscriptional regulators of gene expression. Previous work has suggested that HIV-1 might subvert the function of the cellular miRNA machinery by expressing viral miRNAs or by dramatically altering the level of cellular miRNA expression. Using very sensitive approaches, we now demonstrate that neither of these ideas is in fact correct. Moreover, HIV-1 transcripts appear to largely avoid regulation by cellular miRNAs by adopting an extensive RNA secondary structure that occludes the ability of cellular miRNAs to interact with viral mRNAs. Together, these data suggest that HIV-1, rather than seeking to control miRNA function in infected cells, has instead evolved a mechanism to become largely invisible to cellular miRNA effector mechanisms.
LinkOut: [PMID: 23592263]
CLIP-seq Support 1 for dataset GSM1065667
Method / RBP PAR-CLIP / AGO1
Cell line / Condition HEK293 / 4-thiouridine, ML_MM_6
Location of target site ENST00000373020.4 | 3UTR | UAUACCUAUGUAACAAACCUGCACAUUCUGCACAUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23446348 / GSE43573
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM1462574
Method / RBP PAR-CLIP / AGO2
Cell line / Condition TZM-bl / TZM-bl ami BaL
Location of target site ENST00000373020.4 | 3UTR | AUACCUAUGUAACAAACCUGCACAUUCUGCACAUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23592263 / GSE59944
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
83 hsa-miR-4666a-5p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT057266 FAM35A family with sequence similarity 35 member A 2 2
MIRT059969 PATL1 PAT1 homolog 1, processing body mRNA decay factor 2 6
MIRT079031 TNRC6C trinucleotide repeat containing 6C 2 2
MIRT079631 DNAJB4 DnaJ heat shock protein family (Hsp40) member B4 2 2
MIRT086974 LANCL1 LanC like 1 2 2
MIRT091804 GOLGA4 golgin A4 2 2
MIRT229501 EIF1AX eukaryotic translation initiation factor 1A, X-linked 2 4
MIRT255972 WDR17 WD repeat domain 17 2 2
MIRT262975 ADO 2-aminoethanethiol dioxygenase 2 2
MIRT264774 PAFAH1B2 platelet activating factor acetylhydrolase 1b catalytic subunit 2 2 2
MIRT334169 CCND1 cyclin D1 2 6
MIRT345868 SRSF2 serine and arginine rich splicing factor 2 2 2
MIRT452477 DDX4 DEAD-box helicase 4 2 2
MIRT455764 TSPAN6 tetraspanin 6 2 4
MIRT461627 DCAF15 DDB1 and CUL4 associated factor 15 2 4
MIRT465169 TRPV2 transient receptor potential cation channel subfamily V member 2 2 4
MIRT468950 RPS14 ribosomal protein S14 2 6
MIRT483236 C2orf72 chromosome 2 open reading frame 72 2 8
MIRT498544 TMEM30B transmembrane protein 30B 2 2
MIRT500633 TXNIP thioredoxin interacting protein 2 4
MIRT504113 GPR158 G protein-coupled receptor 158 2 2
MIRT504428 ZNF85 zinc finger protein 85 2 6
MIRT505036 ZNF451 zinc finger protein 451 2 2
MIRT506526 MRPL17 mitochondrial ribosomal protein L17 2 6
MIRT508773 GSG1 germ cell associated 1 2 2
MIRT517297 ELF4 E74 like ETS transcription factor 4 2 6
MIRT519353 OBFC1 STN1, CST complex subunit 2 4
MIRT523891 ENPP6 ectonucleotide pyrophosphatase/phosphodiesterase 6 2 6
MIRT527509 ZNF134 zinc finger protein 134 2 2
MIRT531218 IFNGR2 interferon gamma receptor 2 2 2
MIRT535957 MOGAT1 monoacylglycerol O-acyltransferase 1 2 2
MIRT537229 GALNT7 polypeptide N-acetylgalactosaminyltransferase 7 2 4
MIRT537337 FKBP5 FK506 binding protein 5 2 2
MIRT539125 ARHGEF17 Rho guanine nucleotide exchange factor 17 2 2
MIRT539910 ISPD isoprenoid synthase domain containing 2 2
MIRT541527 MGAT4C MGAT4 family member C 2 2
MIRT546119 USP25 ubiquitin specific peptidase 25 2 2
MIRT548846 CERCAM cerebral endothelial cell adhesion molecule 2 2
MIRT549892 LINC00955 long intergenic non-protein coding RNA 955 2 2
MIRT549898 ADH4 alcohol dehydrogenase 4 (class II), pi polypeptide 2 2
MIRT550763 ENOX2 ecto-NOX disulfide-thiol exchanger 2 2 4
MIRT553200 UBE2A ubiquitin conjugating enzyme E2 A 2 2
MIRT553970 SRSF10 serine and arginine rich splicing factor 10 2 2
MIRT554092 SMU1 DNA replication regulator and spliceosomal factor 2 2
MIRT555208 PROX1 prospero homeobox 1 2 4
MIRT555834 PAX5 paired box 5 2 4
MIRT556865 JAZF1 JAZF zinc finger 1 2 2
MIRT558594 CREBL2 cAMP responsive element binding protein like 2 2 2
MIRT559690 AGO2 argonaute 2, RISC catalytic component 2 4
MIRT563312 ORC4 origin recognition complex subunit 4 2 2
MIRT563585 FAM229B family with sequence similarity 229 member B 2 2
MIRT563853 ALYREF Aly/REF export factor 2 4
MIRT565146 TUBB2A tubulin beta 2A class IIa 2 2
MIRT565769 SEPHS1 selenophosphate synthetase 1 2 2
MIRT568317 BACH1 BTB domain and CNC homolog 1 2 2
MIRT575387 Unc5b unc-5 netrin receptor B 2 4
MIRT607728 BDH1 3-hydroxybutyrate dehydrogenase 1 2 8
MIRT612691 PLXNA4 plexin A4 2 4
MIRT615916 GDPD1 glycerophosphodiester phosphodiesterase domain containing 1 2 2
MIRT629792 P2RY1 purinergic receptor P2Y1 2 2
MIRT632119 FKBP9 FK506 binding protein 9 2 2
MIRT645554 ZDHHC15 zinc finger DHHC-type containing 15 2 4
MIRT651479 WWC3 WWC family member 3 2 2
MIRT654138 RPH3A rabphilin 3A 2 6
MIRT655191 PHAX phosphorylated adaptor for RNA export 2 2
MIRT665543 UNC5B unc-5 netrin receptor B 2 5
MIRT668057 GRIK3 glutamate ionotropic receptor kainate type subunit 3 2 2
MIRT678978 CERS4 ceramide synthase 4 2 4
MIRT679124 RBM3 RNA binding motif (RNP1, RRM) protein 3 2 2
MIRT686776 AZF1 azoospermia factor 1 2 2
MIRT687144 PTPN12 protein tyrosine phosphatase, non-receptor type 12 2 2
MIRT691453 C21orf58 chromosome 21 open reading frame 58 2 2
MIRT691469 FAM98B family with sequence similarity 98 member B 2 2
MIRT697031 UHRF1BP1 UHRF1 binding protein 1 2 2
MIRT698401 TM9SF3 transmembrane 9 superfamily member 3 2 2
MIRT702056 RNMT RNA guanine-7 methyltransferase 2 2
MIRT705903 ADAM9 ADAM metallopeptidase domain 9 2 2
MIRT707491 MMADHC methylmalonic aciduria and homocystinuria, cblD type 2 2
MIRT708080 KLHL23 kelch like family member 23 2 2
MIRT709738 TRIM27 tripartite motif containing 27 2 2
MIRT710056 RWDD2A RWD domain containing 2A 2 2
MIRT710226 KCNK1 potassium two pore domain channel subfamily K member 1 2 2
MIRT712043 STYK1 serine/threonine/tyrosine kinase 1 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-4666a Doxorubicin 31703 NSC123127 approved sensitive High Triple-Negative Breast Cancer cell line (MDA-MB-231, MDA-MB-468)

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