miRTarBase - #MIRT455932


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pre-miRNA Information
pre-miRNA hsa-mir-1247   
Genomic Coordinates chr14: 101560287 - 101560422
Synonyms MIRN1247, hsa-mir-1247, MIR1247
Description Homo sapiens miR-1247 stem-loop
Comment None
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-1247-3p
Sequence 74| CCCCGGGAACGUCGAGACUGGAGC |97
Evidence Not_experimental
Experiments
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs765946490 1 dbSNP
rs1167774642 3 dbSNP
rs369874810 4 dbSNP
rs1295169065 5 dbSNP
rs1368557653 7 dbSNP
rs375254504 10 dbSNP
rs1049152389 16 dbSNP
rs774601647 21 dbSNP
rs1317190334 23 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol HECTD3   
Synonyms -
Description HECT domain E3 ubiquitin protein ligase 3
Transcript NM_024602   
Expression
Putative miRNA Targets on HECTD3
3'UTR of HECTD3
(miRNA target sites are highlighted)		 
>HECTD3|NM_024602|3'UTR
   1 GGCGTGCCGCCGGCTGTGGGACCAGCAAGACTGCACGTGTCCCTCTTGGCCTTGCCCAGGGCGAAGACACCTTCCCTGCC
  81 CTGGTTTGGCTGACGTGCTCAGCAAAACCCCATGTGCCCTGCTCCTGTGTGCAGTTGGGGTAGGGGCAGCTGGCATGGTC
 161 AGGTAACACTAGTGGCCCAGCCCCGCAGACCCACAAGCCCTACCCGTGCTGGGGCTTGCTTCCCGAGGTATTTCACCTCT
 241 TAAGAGGGAATCTTCCACAAGCCCAGCACAAGCTGCCAGGCCTGAGCTACTTGAAGGGGGCCATCTAGGTCCCCAACCCA
 321 TGGACTTTGCCTCCATTTTCAGCTCCGCCTTTTTTCTCCTATTTTCTCTCTGGCTTTCTTCAGCCATGACTCACAACTAA
 401 AAACATAAAACACTGGAGGTTAGTGGAGGCCCCTCCCCAAGCAGGGAGCCTGGGATGGGCAGGGAGTGATAGCCAAACTC
 481 CTTGGTCACCTGCTCCAAGAAGGAAGCAGTAGCTGAGCACCTGCCCTCACATTCTGCTCTTTTCCCCTCTCCCTCCATAC
 561 CAGAGATGTGGTGAGCTCTGTTCTTCTACCAACCCAGTCTCAACACACAAAGTGCCACCACCTTCCCTGACTCAGAACCC
 641 ACATCCACTCAATGTGAACTCTACTACCACGACCTCCCCATATTCCTCACTTCTCCATCACCTCCAGCCTGACTCCCTGT
 721 CTGCCCTTTCACCCCCAAGATTTTGCACAGGTTAAGGCCAGTTATGGCCTTTTTGAAATCTGTAATAGCTCCCCTTTCCC
 801 CAACTCTAAAGCCTAGACCTTAAACCTGTTCCTAGAGCTATGCACACCCCTGCCCCAGTTTACCGTTCCTCCCTCAGGGC
 881 CTCCGTGACACTCCATGAAAAGAAGTTCTTGCATACCGGAAAGTTGAATAAATGGATGAATTCA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' cgaGGUCA-GAGCU---GC-AAGGGCCCc 5'
             || || || |:   :| |||||| | 
Target 5' ctaCCCGTGCTGGGGCTTGCTTCCCGAGg 3'
 200 - 228 121.00 -22.60
2 
miRNA  3' cgAGGUCAGAGCUGCAAGGGCCcc 5'
            ||||| || |||  |||| |  
Target 5' ccTCCAGCCT-GAC--TCCCTGtc 3'
 701 - 721 117.00 -17.50
3 
miRNA  3' cgaGGUCAGA--GCUGCAAGGG---CCCc 5'
             |||||:|  || :  ||||   ||| 
Target 5' gccCCAGTTTACCGTTCCTCCCTCAGGGc 3'
 852 - 880 115.00 -23.00
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN6457503 9 COSMIC
COSN20074058 11 COSMIC
COSN30458861 13 COSMIC
COSN30102607 62 COSMIC
COSN30192353 78 COSMIC
COSN30539158 127 COSMIC
COSN31577860 150 COSMIC
COSN26548567 313 COSMIC
COSN28747553 412 COSMIC
COSN6457502 429 COSMIC
COSN8470874 629 COSMIC
COSN8470873 663 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs113451625 3 dbSNP
rs767740586 4 dbSNP
rs759843479 6 dbSNP
rs774800396 8 dbSNP
rs11548990 9 dbSNP
rs773813792 11 dbSNP
rs1022393546 12 dbSNP
rs1250619110 16 dbSNP
rs770221134 20 dbSNP
rs201951582 21 dbSNP
rs200374828 22 dbSNP
rs369741082 23 dbSNP
rs116477746 25 dbSNP
rs1324254822 31 dbSNP
rs745576935 33 dbSNP
rs778673234 35 dbSNP
rs757083325 36 dbSNP
rs184021803 37 dbSNP
rs777716735 41 dbSNP
rs570627646 42 dbSNP
rs1301508224 43 dbSNP
rs78731459 45 dbSNP
rs752757543 50 dbSNP
rs767510163 51 dbSNP
rs1300030494 59 dbSNP
rs1055479797 61 dbSNP
rs139733899 62 dbSNP
rs562356238 63 dbSNP
rs1258379089 68 dbSNP
rs1316906601 71 dbSNP
rs929232434 72 dbSNP
rs920494115 78 dbSNP
rs1489770256 83 dbSNP
rs1329973987 84 dbSNP
rs1041525211 94 dbSNP
rs945769585 95 dbSNP
rs548484501 97 dbSNP
rs1167362566 108 dbSNP
rs1055013359 112 dbSNP
rs749677406 113 dbSNP
rs528791195 116 dbSNP
rs1465279576 117 dbSNP
rs1197517095 121 dbSNP
rs1480273041 122 dbSNP
rs1458368896 124 dbSNP
rs1292804226 125 dbSNP
rs780339962 127 dbSNP
rs1035578529 128 dbSNP
rs978256951 129 dbSNP
rs1278252845 135 dbSNP
rs1267838767 153 dbSNP
rs955413120 155 dbSNP
rs1439443953 157 dbSNP
rs202167592 162 dbSNP
rs1323816704 163 dbSNP
rs41269095 166 dbSNP
rs540253882 179 dbSNP
rs1010618117 184 dbSNP
rs577674779 185 dbSNP
rs972822304 186 dbSNP
rs192080840 189 dbSNP
rs1008634193 192 dbSNP
rs1184953128 199 dbSNP
rs1415700142 202 dbSNP
rs1016119143 203 dbSNP
rs1048034678 204 dbSNP
rs1363689269 205 dbSNP
rs899080546 206 dbSNP
rs147414733 211 dbSNP
rs1359290202 213 dbSNP
rs1444852880 222 dbSNP
rs575244469 224 dbSNP
rs551703154 225 dbSNP
rs535251862 230 dbSNP
rs1229310980 231 dbSNP
rs1470620092 233 dbSNP
rs1357981266 237 dbSNP
rs1408386624 239 dbSNP
rs573115687 240 dbSNP
rs1286856731 251 dbSNP
rs1034639069 252 dbSNP
rs1446444537 254 dbSNP
rs916566646 264 dbSNP
rs1174380362 266 dbSNP
rs1469433191 273 dbSNP
rs1055158884 281 dbSNP
rs1177529899 298 dbSNP
rs939447038 300 dbSNP
rs1231011929 301 dbSNP
rs35657340 301 dbSNP
rs1159113737 302 dbSNP
rs928037936 307 dbSNP
rs755798239 308 dbSNP
rs978670728 311 dbSNP
rs552816272 316 dbSNP
rs1002785985 319 dbSNP
rs906899923 322 dbSNP
rs533519507 332 dbSNP
rs966903381 332 dbSNP
rs1010012329 341 dbSNP
rs1222186118 345 dbSNP
rs767117244 346 dbSNP
rs756702805 347 dbSNP
rs1242508591 349 dbSNP
rs1203211986 358 dbSNP
rs1241053471 359 dbSNP
rs1458869423 361 dbSNP
rs142802430 391 dbSNP
rs1284478308 392 dbSNP
rs570541038 396 dbSNP
rs764154031 403 dbSNP
rs1425208828 405 dbSNP
rs1413576808 407 dbSNP
rs911391969 412 dbSNP
rs1173744081 419 dbSNP
rs1371610196 423 dbSNP
rs769906600 433 dbSNP
rs1279404802 440 dbSNP
rs1404370219 443 dbSNP
rs1453929904 448 dbSNP
rs1449538685 449 dbSNP
rs1026024665 450 dbSNP
rs1335727523 452 dbSNP
rs550559084 459 dbSNP
rs1276709200 461 dbSNP
rs898987934 470 dbSNP
rs1452049430 483 dbSNP
rs1037608811 484 dbSNP
rs1345904165 489 dbSNP
rs1320258072 496 dbSNP
rs1199094439 501 dbSNP
rs1051321563 505 dbSNP
rs1161525922 506 dbSNP
rs762932349 513 dbSNP
rs770788725 515 dbSNP
rs1436043915 518 dbSNP
rs1200850985 526 dbSNP
rs1399236803 528 dbSNP
rs4660829 533 dbSNP
rs1196631451 549 dbSNP
rs1157838750 552 dbSNP
rs1425387299 553 dbSNP
rs5869 556 dbSNP
rs8681 558 dbSNP
rs1244926358 560 dbSNP
rs1181720079 561 dbSNP
rs1168885182 563 dbSNP
rs761022302 570 dbSNP
rs1242249193 574 dbSNP
rs1217488899 583 dbSNP
rs1314773334 588 dbSNP
rs1326032967 592 dbSNP
rs372440804 597 dbSNP
rs1283934696 601 dbSNP
rs909921199 603 dbSNP
rs772664098 604 dbSNP
rs1342660778 611 dbSNP
rs1219440067 612 dbSNP
rs1250572130 612 dbSNP
rs1337138622 618 dbSNP
rs1211573597 621 dbSNP
rs1490159490 633 dbSNP
rs1362174731 638 dbSNP
rs984641310 642 dbSNP
rs548766753 645 dbSNP
rs528997831 646 dbSNP
rs958830076 647 dbSNP
rs1191950042 649 dbSNP
rs560942986 659 dbSNP
rs981387745 666 dbSNP
rs1165347735 667 dbSNP
rs1366791417 669 dbSNP
rs769274003 670 dbSNP
rs1301412111 684 dbSNP
rs1362489437 685 dbSNP
rs1400855996 686 dbSNP
rs1295041502 688 dbSNP
rs971286773 701 dbSNP
rs1428821667 707 dbSNP
rs1358680627 709 dbSNP
rs138763204 711 dbSNP
rs185003915 718 dbSNP
rs1425028490 723 dbSNP
rs1009878610 725 dbSNP
rs1234094673 726 dbSNP
rs892894214 731 dbSNP
rs1204027169 737 dbSNP
rs1386910640 746 dbSNP
rs1033136336 750 dbSNP
rs1161578515 756 dbSNP
rs910772065 765 dbSNP
rs1006633016 768 dbSNP
rs543835612 769 dbSNP
rs113246343 775 dbSNP
rs1386213973 782 dbSNP
rs1051186084 788 dbSNP
rs532831178 789 dbSNP
rs1484662298 790 dbSNP
rs1382251972 791 dbSNP
rs1262064959 793 dbSNP
rs1026514566 794 dbSNP
rs77867663 799 dbSNP
rs774365914 803 dbSNP
rs1337172459 808 dbSNP
rs1036998878 817 dbSNP
rs769167391 819 dbSNP
rs909884581 821 dbSNP
rs963204218 823 dbSNP
rs1311451575 825 dbSNP
rs991348256 826 dbSNP
rs1012670746 832 dbSNP
rs544971989 836 dbSNP
rs927144550 841 dbSNP
rs1200633537 847 dbSNP
rs981250095 848 dbSNP
rs575316795 853 dbSNP
rs1308605617 857 dbSNP
rs749730479 863 dbSNP
rs971317807 864 dbSNP
rs1020179554 865 dbSNP
rs1212912393 868 dbSNP
rs894401875 869 dbSNP
rs147168479 871 dbSNP
rs780466778 877 dbSNP
rs1467787350 879 dbSNP
rs558406120 881 dbSNP
rs1007075018 885 dbSNP
rs1367198533 890 dbSNP
rs1333089345 891 dbSNP
rs180933151 892 dbSNP
rs1042890279 896 dbSNP
rs1355065336 901 dbSNP
rs1171859571 903 dbSNP
rs1426192216 909 dbSNP
rs1233528138 912 dbSNP
rs1422354766 914 dbSNP
rs945500810 917 dbSNP
rs189985140 918 dbSNP
rs1053964587 919 dbSNP
rs943476936 920 dbSNP
rs1481258009 922 dbSNP
rs572991701 923 dbSNP
rs910845531 924 dbSNP
rs1267132479 932 dbSNP
rs1209639123 934 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions TZM-bl
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM1462574. RNA binding protein: AGO2. Condition:TZM-bl ami BaL ...

- Whisnant AW; Bogerd HP; Flores O; Ho P; et al., 2013, mBio.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' cgaggucagagcugcaAGGGCCCc 5'
                          ||||||| 
Target 5' ----------------UCCCGGGu 3'
 		1 - 8
Article - Whisnant AW; Bogerd HP; Flores O; Ho P; et al.
- mBio, 2013
UNLABELLED: The question of how HIV-1 interfaces with cellular microRNA (miRNA) biogenesis and effector mechanisms has been highly controversial. Here, we first used deep sequencing of small RNAs present in two different infected cell lines (TZM-bl and C8166) and two types of primary human cells (CD4(+) peripheral blood mononuclear cells [PBMCs] and macrophages) to unequivocally demonstrate that HIV-1 does not encode any viral miRNAs. Perhaps surprisingly, we also observed that infection of T cells by HIV-1 has only a modest effect on the expression of cellular miRNAs at early times after infection. Comprehensive analysis of miRNA binding to the HIV-1 genome using the photoactivatable ribonucleoside-induced cross-linking and immunoprecipitation (PAR-CLIP) technique revealed several binding sites for cellular miRNAs, a subset of which were shown to be capable of mediating miRNA-mediated repression of gene expression. However, the main finding from this analysis is that HIV-1 transcripts are largely refractory to miRNA binding, most probably due to extensive viral RNA secondary structure. Together, these data demonstrate that HIV-1 neither encodes viral miRNAs nor strongly influences cellular miRNA expression, at least early after infection, and imply that HIV-1 transcripts have evolved to avoid inhibition by preexisting cellular miRNAs by adopting extensive RNA secondary structures that occlude most potential miRNA binding sites. IMPORTANCE: MicroRNAs (miRNAs) are a ubiquitous class of small regulatory RNAs that serve as posttranscriptional regulators of gene expression. Previous work has suggested that HIV-1 might subvert the function of the cellular miRNA machinery by expressing viral miRNAs or by dramatically altering the level of cellular miRNA expression. Using very sensitive approaches, we now demonstrate that neither of these ideas is in fact correct. Moreover, HIV-1 transcripts appear to largely avoid regulation by cellular miRNAs by adopting an extensive RNA secondary structure that occludes the ability of cellular miRNAs to interact with viral mRNAs. Together, these data suggest that HIV-1, rather than seeking to control miRNA function in infected cells, has instead evolved a mechanism to become largely invisible to cellular miRNA effector mechanisms.
LinkOut: [PMID: 23592263]
CLIP-seq Support 1 for dataset GSM1462574
Method / RBP PAR-CLIP / AGO2
Cell line / Condition TZM-bl / TZM-bl ami BaL
Location of target site ENST00000372168.3 | 3UTR | UCCCGGGUUCAAACAAUUCUCCUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23592263 / GSE59944
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
228 hsa-miR-1247-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT107246 PTGES2 prostaglandin E synthase 2 2 2
MIRT118004 BLOC1S3 biogenesis of lysosomal organelles complex 1 subunit 3 2 6
MIRT345983 BIRC5 baculoviral IAP repeat containing 5 2 4
MIRT369967 ZNF264 zinc finger protein 264 2 2
MIRT451350 ZNF573 zinc finger protein 573 2 4
MIRT451367 UQCR11 ubiquinol-cytochrome c reductase, complex III subunit XI 2 2
MIRT451450 ZNF556 zinc finger protein 556 2 4
MIRT451766 ZNF611 zinc finger protein 611 2 6
MIRT452065 ZNF585B zinc finger protein 585B 2 8
MIRT452346 TG thyroglobulin 2 2
MIRT452519 TFDP2 transcription factor Dp-2 2 6
MIRT452631 FAM162A family with sequence similarity 162 member A 2 2
MIRT452896 PSD4 pleckstrin and Sec7 domain containing 4 2 4
MIRT453263 PARP11 poly(ADP-ribose) polymerase family member 11 2 2
MIRT453567 RDH13 retinol dehydrogenase 13 2 2
MIRT453911 GABRR2 gamma-aminobutyric acid type A receptor rho2 subunit 2 4
MIRT454576 NT5DC3 5'-nucleotidase domain containing 3 2 2
MIRT454859 ACOT9 acyl-CoA thioesterase 9 2 4
MIRT455094 NMNAT1 nicotinamide nucleotide adenylyltransferase 1 2 2
MIRT455790 TAF8 TATA-box binding protein associated factor 8 2 2
MIRT455932 HECTD3 HECT domain E3 ubiquitin protein ligase 3 2 2
MIRT456213 LIX1L limb and CNS expressed 1 like 2 4
MIRT456238 LHPP phospholysine phosphohistidine inorganic pyrophosphate phosphatase 2 6
MIRT456279 HRNR hornerin 2 2
MIRT456665 TIFA TRAF interacting protein with forkhead associated domain 2 2
MIRT457088 XPNPEP3 X-prolyl aminopeptidase 3 2 2
MIRT457322 DUSP19 dual specificity phosphatase 19 2 2
MIRT457695 ZNF587 zinc finger protein 587 2 4
MIRT458160 LYRM4 LYR motif containing 4 2 6
MIRT458465 SNX22 sorting nexin 22 2 8
MIRT458504 MARVELD2 MARVEL domain containing 2 2 2
MIRT458514 GSG2 histone H3 associated protein kinase 2 10
MIRT458645 SGPP2 sphingosine-1-phosphate phosphatase 2 2 2
MIRT458823 ZNF843 zinc finger protein 843 2 4
MIRT459156 NARF nuclear prelamin A recognition factor 2 2
MIRT459182 HSPA6 heat shock protein family A (Hsp70) member 6 2 4
MIRT459374 MPLKIP M-phase specific PLK1 interacting protein 2 6
MIRT459552 BTD biotinidase 2 2
MIRT459756 SNRPD1 small nuclear ribonucleoprotein D1 polypeptide 2 2
MIRT459860 SVOP SV2 related protein 2 8
MIRT460020 DTX3L deltex E3 ubiquitin ligase 3L 2 6
MIRT460233 TNFRSF13C TNF receptor superfamily member 13C 2 2
MIRT460275 SLC26A2 solute carrier family 26 member 2 2 2
MIRT460461 NOM1 nucleolar protein with MIF4G domain 1 2 4
MIRT460540 TM4SF5 transmembrane 4 L six family member 5 2 2
MIRT460551 IFNAR1 interferon alpha and beta receptor subunit 1 2 6
MIRT460978 STK17B serine/threonine kinase 17b 2 2
MIRT461421 CTSL2 cathepsin V 1 2
MIRT461960 C3 complement C3 2 4
MIRT462529 DHODH dihydroorotate dehydrogenase (quinone) 2 6
MIRT462864 CYP51A1 cytochrome P450 family 51 subfamily A member 1 2 2
MIRT462917 ZNRF3 zinc and ring finger 3 2 2
MIRT463022 ZNF70 zinc finger protein 70 2 2
MIRT463074 ZNF639 zinc finger protein 639 2 2
MIRT463130 ZNF451 zinc finger protein 451 2 4
MIRT463627 YY1 YY1 transcription factor 2 2
MIRT467015 SSBP2 single stranded DNA binding protein 2 2 2
MIRT467127 SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 2 8
MIRT468526 SERTAD2 SERTA domain containing 2 2 4
MIRT468584 SERBP1 SERPINE1 mRNA binding protein 1 2 6
MIRT469540 RBBP8 RB binding protein 8, endonuclease 2 2
MIRT469876 PURB purine rich element binding protein B 2 4
MIRT471577 PARD6B par-6 family cell polarity regulator beta 2 2
MIRT472110 NME2 NME/NM23 nucleoside diphosphate kinase 2 2 2
MIRT472127 NME1-NME2 NME1-NME2 readthrough 2 2
MIRT472423 NCKAP1 NCK associated protein 1 2 2
MIRT472829 MTMR10 myotubularin related protein 10 2 4
MIRT473022 MRPS14 mitochondrial ribosomal protein S14 2 2
MIRT473408 MDM4 MDM4, p53 regulator 2 2
MIRT474122 LIPC lipase C, hepatic type 2 2
MIRT474927 KCTD20 potassium channel tetramerization domain containing 20 2 2
MIRT476807 FNDC3B fibronectin type III domain containing 3B 2 2
MIRT478006 DNAL1 dynein axonemal light chain 1 2 2
MIRT479200 CLCN5 chloride voltage-gated channel 5 2 6
MIRT479671 CCSER2 coiled-coil serine rich protein 2 2 2
MIRT479917 CCDC117 coiled-coil domain containing 117 2 6
MIRT479977 CARD10 caspase recruitment domain family member 10 2 2
MIRT480731 BPTF bromodomain PHD finger transcription factor 2 6
MIRT481100 B3GALNT2 beta-1,3-N-acetylgalactosaminyltransferase 2 2 2
MIRT481160 AVL9 AVL9 cell migration associated 2 6
MIRT481393 ATG12 autophagy related 12 2 2
MIRT481433 ASB6 ankyrin repeat and SOCS box containing 6 2 2
MIRT482083 ALG9 ALG9, alpha-1,2-mannosyltransferase 2 2
MIRT484667 HOXD3 homeobox D3 2 4
MIRT485940 ECSIT ECSIT signalling integrator 2 4
MIRT485950 BRSK1 BR serine/threonine kinase 1 2 2
MIRT487600 NKD2 naked cuticle homolog 2 2 4
MIRT487666 HPCAL1 hippocalcin like 1 2 4
MIRT489966 GNB2 G protein subunit beta 2 2 2
MIRT490332 ANK1 ankyrin 1 2 4
MIRT491314 LRFN1 leucine rich repeat and fibronectin type III domain containing 1 2 2
MIRT493193 MINK1 misshapen like kinase 1 2 4
MIRT493300 LLGL2 LLGL2, scribble cell polarity complex component 2 2
MIRT493816 FSCN1 fascin actin-bundling protein 1 2 2
MIRT496977 RPS6KA2 ribosomal protein S6 kinase A2 2 2
MIRT512229 ATXN3 ataxin 3 2 6
MIRT515141 ZNF799 zinc finger protein 799 2 4
MIRT516647 SMC5 structural maintenance of chromosomes 5 2 2
MIRT517952 TRIM59 tripartite motif containing 59 2 2
MIRT520971 SPPL2A signal peptide peptidase like 2A 2 4
MIRT521569 PTPLB 3-hydroxyacyl-CoA dehydratase 2 1 1
MIRT522918 KCNE3 potassium voltage-gated channel subfamily E regulatory subunit 3 2 2
MIRT532713 SNRPD3 small nuclear ribonucleoprotein D3 polypeptide 2 2
MIRT540809 SLC35F5 solute carrier family 35 member F5 2 2
MIRT550734 PMPCA peptidase, mitochondrial processing alpha subunit 2 4
MIRT551293 MCF2L2 MCF.2 cell line derived transforming sequence-like 2 2 4
MIRT559740 ACOX1 acyl-CoA oxidase 1 2 2
MIRT564410 EMILIN2 elastin microfibril interfacer 2 2 2
MIRT565240 TRAF6 TNF receptor associated factor 6 2 2
MIRT568911 ATP6V1B1 ATPase H+ transporting V1 subunit B1 2 2
MIRT575232 Fut1 fucosyltransferase 1 2 2
MIRT576224 Srsf1 serine/arginine-rich splicing factor 1 2 2
MIRT607724 LIMS1 LIM zinc finger domain containing 1 2 2
MIRT608090 CRISPLD2 cysteine rich secretory protein LCCL domain containing 2 2 2
MIRT613920 POU3F1 POU class 3 homeobox 1 2 2
MIRT618520 SELPLG selectin P ligand 2 2
MIRT624703 AQR aquarius intron-binding spliceosomal factor 2 2
MIRT624770 AKR1D1 aldo-keto reductase family 1 member D1 2 2
MIRT625720 SPI1 Spi-1 proto-oncogene 2 2
MIRT629975 MRPL36 mitochondrial ribosomal protein L36 2 2
MIRT631356 ZFP82 ZFP82 zinc finger protein 2 2
MIRT631426 CDNF cerebral dopamine neurotrophic factor 2 2
MIRT631665 NDUFV3 NADH:ubiquinone oxidoreductase subunit V3 2 2
MIRT631735 SF3B1 splicing factor 3b subunit 1 2 2
MIRT632334 TCEANC2 transcription elongation factor A N-terminal and central domain containing 2 2 2
MIRT632419 SLC30A5 solute carrier family 30 member 5 2 2
MIRT632531 PSMB2 proteasome subunit beta 2 2 2
MIRT633264 LDLR low density lipoprotein receptor 2 2
MIRT634327 SLC43A2 solute carrier family 43 member 2 2 2
MIRT634753 CRCP CGRP receptor component 2 2
MIRT635412 KIAA1614 KIAA1614 2 2
MIRT636281 RFFL ring finger and FYVE like domain containing E3 ubiquitin protein ligase 2 2
MIRT636291 RAD51L3-RFFL RAD51L3-RFFL readthrough 2 2
MIRT640265 FANCA Fanconi anemia complementation group A 2 2
MIRT641738 TXNL1 thioredoxin like 1 2 2
MIRT643276 ZNF566 zinc finger protein 566 2 2
MIRT643528 ERAP2 endoplasmic reticulum aminopeptidase 2 2 2
MIRT643555 C11orf70 chromosome 11 open reading frame 70 2 2
MIRT647027 NQO2 N-ribosyldihydronicotinamide:quinone reductase 2 2 2
MIRT647298 RBM43 RNA binding motif protein 43 2 2
MIRT648124 SEMA3E semaphorin 3E 2 4
MIRT648611 TPCN2 two pore segment channel 2 2 2
MIRT648717 IL10RB interleukin 10 receptor subunit beta 2 2
MIRT649425 CDC14B cell division cycle 14B 2 2
MIRT650029 DSG3 desmoglein 3 2 2
MIRT650281 TAS2R5 taste 2 receptor member 5 2 2
MIRT650529 CCDC77 coiled-coil domain containing 77 2 2
MIRT654240 RNF115 ring finger protein 115 2 2
MIRT657032 KCNJ6 potassium voltage-gated channel subfamily J member 6 2 2
MIRT658408 FAM212B family with sequence similarity 212 member B 2 2
MIRT659442 CNNM4 cyclin and CBS domain divalent metal cation transport mediator 4 2 2
MIRT661080 FFAR2 free fatty acid receptor 2 2 2
MIRT661529 NWD1 NACHT and WD repeat domain containing 1 2 2
MIRT661876 PDLIM5 PDZ and LIM domain 5 2 2
MIRT662100 ZNF419 zinc finger protein 419 2 2
MIRT662136 ZC3H8 zinc finger CCCH-type containing 8 2 2
MIRT663638 HM13 histocompatibility minor 13 2 2
MIRT663703 ABHD17B abhydrolase domain containing 17B 2 2
MIRT663847 TRIM72 tripartite motif containing 72 2 2
MIRT664769 MESDC2 mesoderm development LRP chaperone 2 2
MIRT665481 VSTM4 V-set and transmembrane domain containing 4 2 2
MIRT666533 RNF157 ring finger protein 157 2 2
MIRT668107 GK5 glycerol kinase 5 (putative) 2 2
MIRT668984 CKAP4 cytoskeleton associated protein 4 2 4
MIRT669742 HSPE1-MOB4 HSPE1-MOB4 readthrough 2 2
MIRT671010 MOB4 MOB family member 4, phocein 2 2
MIRT671583 SPIRE2 spire type actin nucleation factor 2 2 2
MIRT673261 INO80 INO80 complex subunit 2 2
MIRT673533 ADRBK2 G protein-coupled receptor kinase 3 2 2
MIRT674714 FAM73A mitoguardin 1 2 2
MIRT675205 ZNF554 zinc finger protein 554 2 2
MIRT676488 DSN1 DSN1 homolog, MIS12 kinetochore complex component 2 2
MIRT676705 GXYLT2 glucoside xylosyltransferase 2 2 2
MIRT676851 ZMYM1 zinc finger MYM-type containing 1 2 2
MIRT676855 RAB3B RAB3B, member RAS oncogene family 2 2
MIRT676915 PHLDA3 pleckstrin homology like domain family A member 3 2 2
MIRT677000 CYP20A1 cytochrome P450 family 20 subfamily A member 1 2 2
MIRT677188 PDE12 phosphodiesterase 12 2 2
MIRT677473 SLC7A11 solute carrier family 7 member 11 2 2
MIRT677562 C19orf52 translocase of inner mitochondrial membrane 29 2 2
MIRT677779 FKTN fukutin 2 2
MIRT677896 DCP1A decapping mRNA 1A 2 2
MIRT677996 GATC glutamyl-tRNA amidotransferase subunit C 2 2
MIRT678239 HMGB1 high mobility group box 1 2 4
MIRT678313 MCM8 minichromosome maintenance 8 homologous recombination repair factor 2 2
MIRT678437 PDE4C phosphodiesterase 4C 2 2
MIRT678480 RNF222 ring finger protein 222 2 2
MIRT678591 ZNF91 zinc finger protein 91 2 2
MIRT678863 SLC7A14 solute carrier family 7 member 14 2 2
MIRT679241 LRP10 LDL receptor related protein 10 2 2
MIRT679388 WDR92 WD repeat domain 92 2 2
MIRT679501 ZNF106 zinc finger protein 106 2 2
MIRT679581 UGGT1 UDP-glucose glycoprotein glucosyltransferase 1 2 2
MIRT679827 TMEM106B transmembrane protein 106B 2 2
MIRT679842 GPR75 G protein-coupled receptor 75 2 2
MIRT679860 ZFP30 ZFP30 zinc finger protein 2 2
MIRT680733 PRICKLE1 prickle planar cell polarity protein 1 2 2
MIRT680922 STX2 syntaxin 2 2 2
MIRT680953 CEP104 centrosomal protein 104 2 2
MIRT681053 ZDBF2 zinc finger DBF-type containing 2 2 2
MIRT681967 TFCP2 transcription factor CP2 2 2
MIRT682010 ATP5S ATP synthase, H+ transporting, mitochondrial Fo complex subunit s (factor B) 2 2
MIRT682061 B4GALT7 beta-1,4-galactosyltransferase 7 2 4
MIRT682070 QPCTL glutaminyl-peptide cyclotransferase like 2 2
MIRT683356 SCARF1 scavenger receptor class F member 1 2 2
MIRT683699 LAX1 lymphocyte transmembrane adaptor 1 2 2
MIRT684268 PRPF4 pre-mRNA processing factor 4 2 2
MIRT685500 MED16 mediator complex subunit 16 2 2
MIRT686876 SLC25A32 solute carrier family 25 member 32 2 2
MIRT690869 PLEKHG2 pleckstrin homology and RhoGEF domain containing G2 2 2
MIRT691139 HJURP Holliday junction recognition protein 2 2
MIRT691195 NIF3L1 NGG1 interacting factor 3 like 1 2 2
MIRT691780 SLC24A4 solute carrier family 24 member 4 2 2
MIRT692901 MPL MPL proto-oncogene, thrombopoietin receptor 2 2
MIRT694551 BPNT1 3'(2'), 5'-bisphosphate nucleotidase 1 2 2
MIRT695421 ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide 2 2
MIRT695956 FANCM Fanconi anemia complementation group M 2 2
MIRT696615 CRIPT CXXC repeat containing interactor of PDZ3 domain 2 2
MIRT700682 PPAP2B phospholipid phosphatase 3 2 2
MIRT701215 ORAI2 ORAI calcium release-activated calcium modulator 2 2 2
MIRT702196 LRRC58 leucine rich repeat containing 58 2 2
MIRT702837 HOOK3 hook microtubule tethering protein 3 2 2
MIRT703652 FAM60A SIN3-HDAC complex associated factor 2 2
MIRT705679 ANKRD40 ankyrin repeat domain 40 2 2
MIRT706650 SMIM19 small integral membrane protein 19 2 2
MIRT711087 NEUROD2 neuronal differentiation 2 2 2
MIRT724961 PTK6 protein tyrosine kinase 6 2 2
MIRT735597 BCL6 B-cell CLL/lymphoma 6 1 0
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-1247 Ceritinib 57379345 NSC776422 approved resistant High Non-Small Cell Lung Cancer cell line (H3122, H2228)
hsa-mir-1247 Cisplatin 5460033 NSC119875 approved sensitive High Ovarian Cancer cell line (A2780CIS)
hsa-mir-1247 Sorafenib 216239 NSC747971 approved sensitive High Hepatocellular Carcinoma tissue
hsa-mir-1247 Cisplatin 5460033 NSC119875 approved sensitive cell line (CIS)
hsa-mir-1247 Androstenedione 6128 NSC9563 resistant cell line (MCF-7)
hsa-mir-1247 Androstenedione+Anastrozole resistant cell line (MCF-7)
hsa-mir-1247 Androstenedione+Letrozole resistant cell line (MCF-7)
hsa-mir-1247 Fluorouracil 3385 NSC19893 approved resistant cell line (OE19)
hsa-mir-1247 Cisplatin 5460033 NSC119875 approved resistant cell line (BxPC3)
hsa-mir-1247 Ceritinib 57379345 NSC776422 approved resistant cell line (H3122)
hsa-miR-1247-3p Gemcitabine 60750 NSC613327 approved sensitive High Pancreatic Cancer cell line (SW1990)
hsa-miR-1247-3p Gefitinib 123631 NSC715055 approved resistant High Non-Small Cell Lung Cancer cell line (PC-9)
hsa-miR-1247-3p Gefitinib 123631 NSC715055 approved sensitive High Non-Small Cell Lung Cancer cell line (PC-9)
hsa-miR-1247-3p Yuanhuadine 6440572 resistant High Non-Small Cell Lung Cancer cell line (PC-9)
hsa-miR-1247-3p Cisplatin 5460033 NSC119875 approved sensitive High Non-Small Cell Lung Cancer cell line (A549, HCC827)
hsa-miR-1247-3p Gefitinib 123631 NSC715055 approved sensitive High Non-Small Cell Lung Cancer cell line (A549, HCC827)
hsa-miR-1247-3p Oxaliplatin 6857599 NSC266046 approved sensitive Low Colorectal Cancer cell line (HCT-116)
hsa-miR-1247-3p Gefitinib 123631 NSC715055 approved sensitive cell line (PC9)
hsa-miR-1247-3p Osimertinib 71496458 NSC779217 approved resistant cell line (HCC827)
hsa-miR-1247-3p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-1247-3p Gefitinib 123631 NSC715055 approved sensitive cell line (HCC827)
hsa-miR-1247-3p Osimertinib 71496458 NSC779217 approved sensitive cell line (H1975)
hsa-miR-1247-3p Gemcitabine 60750 NSC613327 approved resistant cell line (PANC-1) (100 ng/ml)
hsa-miR-1247-3p Gemcitabine 60750 NSC613327 approved resistant cell line (PANC-1) (1500 ng/ml)
hsa-miR-1247-3p Ceritinib 57379345 NSC776422 approved resistant cell line (H3122)

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