miRTarBase - #MIRT456105


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pre-miRNA Information
pre-miRNA hsa-mir-939   
Genomic Coordinates chr8: 144394149 - 144394230
Synonyms MIRN939, hsa-mir-939, MIR939
Description Homo sapiens miR-939 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-939-3p
Sequence 50| CCCUGGGCCUCUGCUCCCCAG |70
Evidence Not_experimental
Experiments
DRVs in miRNA
Mutant ID Mutant Position Mutant Source
COSM8840035 17 COSMIC
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1179840180 2 dbSNP
rs782211712 4 dbSNP
rs562433649 11 dbSNP
rs1419593215 12 dbSNP
rs782285221 16 dbSNP
rs35486628 20 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol VAV3   
Synonyms -
Description vav guanine nucleotide exchange factor 3
Transcript NM_001079874   
Other Transcripts NM_006113   
Expression
Putative miRNA Targets on VAV3
3'UTR of VAV3
(miRNA target sites are highlighted)		 
>VAV3|NM_001079874|3'UTR
   1 ATTCAAATCCCGTGTTGCACCCTGCACCAAAAATTTCAGAGAAGGGATAAATAGAAGCCTGCACAGCATCGTGAATTAAC
  81 TGAAGTGTTTAAAAAGCTGCATTTCTGGCTGTTCAACATCCTCCCTCCTTAGCCCCTCCTAAGTCTTAATGCTGAGATTT
 161 CTAAAGATGCTGGTACTGACAGATTAATGGCTTGCCTAGAGCTGTGCAAGAAACAGCCTGCCAGTCTGTCATTGTCAGGG
 241 ACCAGGGCAAAACCAAGAGCTGTTCTTCCCAGAAGAGCCCTGCAAACACATTGGTTCGTGCTTCCCTTTACTTCTTCTGG
 321 TCAGATACCATGAATGCCAGTCATCAGTAAATCTTAATACACTTTTGCTTTATTCTCACATGCCATTCACCAGATTATTT
 401 GATGGTACAAAGAAGCAGAAGTGTAATTTTCCTTTTCCCAGCATGACGAAAAATTGGAGTTCTGCCATTTGAGCAGCTTA
 481 CTGGAAAGATCCAGCCTTACTTGTCTTAAATTGTCCAACAAGGTGACTCATTGCCCGGCAAACACTTTTACCCTCAGATG
 561 TTACTCATGATATTATAAAATATGAGGCCAGTGCTCAGGTTTGCATCATAAGTGAGCTATCCCTGAAGGGTTTTAATTAC
 641 TTATTTGGTGTCCTGATTATATTTGCAAACTTCTTTATAAAAGGTGAAAAAAGCACACAAAAGAGAGGGTGTCTTCATAT
 721 TAAACCTTCACAACCTTCATGATTTCATAGGATTATTTTGGAAATATAGCACTTGACTTTATGAAAGGATCTGGGCTAGG
 801 TATATTAAGGGTAGTTGCCAATAACCTGAAGAAGCTGGCATTGTTTACAGAAACAGATCAAGGGCTATAATTTATGTCAT
 881 TTTATAGCAGCAGTATCTATTAATACATGCCTTTTCCTCCCATCCACCTCCCCCGCACACACACAAAGATGACCTGGGAC
 961 ATGATTTTTTTATTCCCACATTTTCTTGGAGCACAAACAACTTTGTTGAGGATTTTGGAAGGAAAGCACAACTGGGTCCT
1041 TTATTCATTTCTGGGACAGAAAGAGGGTCAGTGGACTTTTGTGGGCCTCCAGCTTCTCTCAGAGTCTCCCCCTCTGCAGC
1121 CCATCCTGGGAGTGTATTAACTGGAGGGAAGATGGGTCTTGCAGTACATTTGTTTTGCCCAGCCATCACTCTTTTTTGTG
1201 AGGAGCCTAAATACATTCTTCCTGGGGTCCAGAGTCCCCATTCAAGGCAGTCAAGTTAAGACACTAACTTGGCCCTTTCC
1281 TGATGGAAATATTTCCTCCATAGCAGAAGTTGTGTTCTGACAAGACTGAGAGAGTTACATGTTGGGAAAAAAAAGAAGCA
1361 TTAACTTAGTAGAACTGAACCAGGAGCATTAAGTTCTGAAATTTTGAATCATCTCTGAAATGAAGCAGGTGTAGCCTGCC
1441 CTCTCATCAATCCGTCTGGGTGCCAGAACTCAAGGTTCAGTGGACACATCCCCCTGTTAGAGACCCTCATGGGCTAGGAC
1521 TTTTCATCTAGGATAGATTCAAGACCTTTACCTCAGAATTATGTAAACTGTGATTGTGTTTTAGAAAAATTATTATTTGC
1601 TAAAACCATTTAAGTCTTTGTATATGTGTAAATGATCACAAAAATGTATTTTATAAAATGTTCTGTACAATAAAGTTACA
1681 CCTCAAAGTGTACTCTTGGAATGGATTCTTTCCTGTAAAGTCTTATCTGCGACTCTGTCTCGGGAATGTTTTGTCTGTTG
1761 CCGTCAGCCGAACTTTGTTATGGAGGGAGCAGCCTCACACAAGCAGAAACACTCCTGTGGATGGTATTGTAGCATGTATT
1841 GTTTATTTTAGTCAATAGACCCTCTCCTTATAAATGGTGTTTAGTCTTCCTGTTGCATTTCATGGGCCTGGGGGTTTCCT
1921 AGCAGAGGATATTGGAGCCCCTTTTTGTGACATTACCAATTACATCTTTGTCCACGTTTAATACTTTGTTTTGGAAAATT
2001 TAAATGCTGCAGATTTGTGTAGAGTTCTAATACCAAAGACAGAAGTAAATGTTTTCCATATACTTTGTCTTGCCTGTATG
2081 CAGCCCTCGTGTAATACGGTGAATTAGAGTGGTATTTCACTTTGTATTATTTTGTAAATATGTCAATATAATAAATAGTG
2161 ACTAAATTGATAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' gacCCCUCGUCUCCGGGUCCc 5'
             | |: |||  ||:|||| 
Target 5' tatGAGGCCAG-TGCTCAGGt 3'
 581 - 600 133.00 -15.10
2 
miRNA  3' gaccccucGUCUCCGGGUCCc 5'
                  || :||||::|| 
Target 5' ttgcatttCATGGGCCTGGGg 3'
 1893 - 1913 121.00 -19.00
3 
miRNA  3' gaccccucgucucCGGGUCcc 5'
                       ||||||  
Target 5' gtacatttgttttGCCCAGcc 3'
 1164 - 1184 120.00 -9.90
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN31502367 4 COSMIC
COSN31586685 9 COSMIC
COSN30190063 11 COSMIC
COSN30157171 14 COSMIC
COSN30530097 39 COSMIC
COSN30467196 41 COSMIC
COSN28890895 48 COSMIC
COSN31497903 59 COSMIC
COSN30496500 66 COSMIC
COSN16130371 71 COSMIC
COSN30121012 73 COSMIC
COSN30145613 97 COSMIC
COSN5997710 200 COSMIC
COSN31604784 201 COSMIC
COSN31558367 297 COSMIC
COSN22830101 306 COSMIC
COSN30110134 312 COSMIC
COSN14630292 412 COSMIC
COSN27551202 423 COSMIC
COSN26816061 430 COSMIC
COSN30159407 534 COSMIC
COSN21079365 649 COSMIC
COSN30159411 661 COSMIC
COSN31542772 909 COSMIC
COSN1400222 998 COSMIC
COSN15787954 1128 COSMIC
COSN17690417 1347 COSMIC
COSN26549757 1448 COSMIC
COSN30159373 1456 COSMIC
COSN28453565 1533 COSMIC
COSN31529579 1543 COSMIC
COSN31608378 1590 COSMIC
COSN1400221 1608 COSMIC
COSN19490088 1639 COSMIC
COSN17181578 1730 COSMIC
COSN5196995 1743 COSMIC
COSN1400220 1858 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs899446923 2 dbSNP
rs764955911 7 dbSNP
rs1313247484 9 dbSNP
rs759402727 10 dbSNP
rs776619927 11 dbSNP
rs542122942 12 dbSNP
rs746574187 17 dbSNP
rs772705792 18 dbSNP
rs771713648 25 dbSNP
rs747774059 28 dbSNP
rs1368650134 38 dbSNP
rs1192974517 39 dbSNP
rs779276047 40 dbSNP
rs755398431 41 dbSNP
rs749808685 43 dbSNP
rs1490210379 44 dbSNP
rs780763388 48 dbSNP
rs375285827 49 dbSNP
rs373579542 50 dbSNP
rs377617538 58 dbSNP
rs1057441540 61 dbSNP
rs938783918 62 dbSNP
rs1011986853 64 dbSNP
rs927349946 67 dbSNP
rs752422079 70 dbSNP
rs767367610 71 dbSNP
rs62618754 82 dbSNP
rs1430286210 87 dbSNP
rs1333171129 91 dbSNP
rs535993365 96 dbSNP
rs182104204 105 dbSNP
rs112965883 110 dbSNP
rs989420542 114 dbSNP
rs112107766 115 dbSNP
rs1024102601 121 dbSNP
rs754798816 123 dbSNP
rs1459449943 125 dbSNP
rs546353195 149 dbSNP
rs956791059 151 dbSNP
rs1248147881 162 dbSNP
rs1480462582 167 dbSNP
rs143546591 173 dbSNP
rs17019458 185 dbSNP
rs1334557922 194 dbSNP
rs1473540188 198 dbSNP
rs1240388647 204 dbSNP
rs1406976053 209 dbSNP
rs1192088612 220 dbSNP
rs886186908 231 dbSNP
rs1451421854 239 dbSNP
rs1405589169 258 dbSNP
rs1302654247 261 dbSNP
rs189767773 262 dbSNP
rs745658316 269 dbSNP
rs1288616864 276 dbSNP
rs1210073527 279 dbSNP
rs1048831852 287 dbSNP
rs1280709403 294 dbSNP
rs188091969 298 dbSNP
rs1258507678 307 dbSNP
rs954488718 313 dbSNP
rs1490419039 314 dbSNP
rs1221018719 317 dbSNP
rs532627404 321 dbSNP
rs574887881 324 dbSNP
rs1266156824 331 dbSNP
rs1377622751 334 dbSNP
rs1483789612 340 dbSNP
rs1182424415 342 dbSNP
rs1363203875 345 dbSNP
rs1468380072 356 dbSNP
rs1164812896 361 dbSNP
rs1028679964 362 dbSNP
rs1311406281 375 dbSNP
rs1438391539 377 dbSNP
rs1330306396 387 dbSNP
rs1324383306 390 dbSNP
rs1411806851 402 dbSNP
rs1040335383 422 dbSNP
rs554999439 431 dbSNP
rs942978542 436 dbSNP
rs1335722623 438 dbSNP
rs1440413224 439 dbSNP
rs538183134 444 dbSNP
rs899350615 445 dbSNP
rs946234154 447 dbSNP
rs569111481 448 dbSNP
rs1343654559 450 dbSNP
rs552120373 456 dbSNP
rs774325091 471 dbSNP
rs1189292345 474 dbSNP
rs957581465 475 dbSNP
rs748820963 477 dbSNP
rs1057163885 480 dbSNP
rs770880777 480 dbSNP
rs1183207538 489 dbSNP
rs1383667099 494 dbSNP
rs368091734 495 dbSNP
rs927256591 498 dbSNP
rs1396337585 500 dbSNP
rs1408721878 510 dbSNP
rs971292158 512 dbSNP
rs1383973641 518 dbSNP
rs1452432835 522 dbSNP
rs1024218504 524 dbSNP
rs3187207 536 dbSNP
rs755527195 537 dbSNP
rs1337288201 539 dbSNP
rs1202100293 540 dbSNP
rs1263738274 546 dbSNP
rs947418853 551 dbSNP
rs886303044 558 dbSNP
rs1241473648 563 dbSNP
rs1027799875 567 dbSNP
rs1287991296 570 dbSNP
rs994616687 572 dbSNP
rs900137130 589 dbSNP
rs1474501789 606 dbSNP
rs1179182908 607 dbSNP
rs1344018968 611 dbSNP
rs915081911 628 dbSNP
rs989716544 644 dbSNP
rs17236113 646 dbSNP
rs1386170633 647 dbSNP
rs1438847157 664 dbSNP
rs923840301 666 dbSNP
rs1386601845 669 dbSNP
rs561891598 682 dbSNP
rs78755947 687 dbSNP
rs140026517 693 dbSNP
rs891381167 693 dbSNP
rs1297853088 694 dbSNP
rs146083978 698 dbSNP
rs954394274 703 dbSNP
rs1234842149 704 dbSNP
rs1283812866 704 dbSNP
rs1322761593 705 dbSNP
rs1051377644 708 dbSNP
rs1400613658 708 dbSNP
rs1362549407 709 dbSNP
rs1028585134 717 dbSNP
rs1269790261 718 dbSNP
rs1486110578 722 dbSNP
rs1205933131 725 dbSNP
rs766838325 731 dbSNP
rs963097724 735 dbSNP
rs1016468527 739 dbSNP
rs1005449693 742 dbSNP
rs1426276307 743 dbSNP
rs1430546531 748 dbSNP
rs550153997 752 dbSNP
rs936110112 758 dbSNP
rs1365908239 762 dbSNP
rs758971235 767 dbSNP
rs980126740 769 dbSNP
rs1406196000 776 dbSNP
rs1420977816 780 dbSNP
rs373675100 787 dbSNP
rs2769668 808 dbSNP
rs1044378034 810 dbSNP
rs947491284 813 dbSNP
rs563214531 818 dbSNP
rs1317273321 821 dbSNP
rs1053654190 824 dbSNP
rs1485027172 826 dbSNP
rs1224736003 827 dbSNP
rs546154570 835 dbSNP
rs3187208 842 dbSNP
rs528500620 843 dbSNP
rs1490225090 848 dbSNP
rs1197876290 850 dbSNP
rs1253342668 854 dbSNP
rs1207931766 856 dbSNP
rs1420015641 856 dbSNP
rs950532634 857 dbSNP
rs923772107 859 dbSNP
rs1441817268 861 dbSNP
rs987359773 862 dbSNP
rs1027501550 863 dbSNP
rs765520249 867 dbSNP
rs17019453 869 dbSNP
rs921645000 877 dbSNP
rs1315843135 879 dbSNP
rs1402617184 893 dbSNP
rs974374964 899 dbSNP
rs373735946 918 dbSNP
rs563642212 918 dbSNP
rs1390553724 922 dbSNP
rs1304612408 925 dbSNP
rs963190594 928 dbSNP
rs1248436241 930 dbSNP
rs1292852902 931 dbSNP
rs890153607 934 dbSNP
rs536707914 935 dbSNP
rs753959740 937 dbSNP
rs1481254697 946 dbSNP
rs1176918973 947 dbSNP
rs1248856445 948 dbSNP
rs1446882752 950 dbSNP
rs1051328282 965 dbSNP
rs1282542428 989 dbSNP
rs1016410770 991 dbSNP
rs1354977703 992 dbSNP
rs891926535 993 dbSNP
rs1054634502 996 dbSNP
rs1384704360 998 dbSNP
rs983199526 1004 dbSNP
rs1315957874 1005 dbSNP
rs570780511 1010 dbSNP
rs1226626878 1016 dbSNP
rs552512219 1019 dbSNP
rs1447921069 1030 dbSNP
rs1360204420 1033 dbSNP
rs191620266 1035 dbSNP
rs1204427813 1038 dbSNP
rs1256770005 1040 dbSNP
rs927395397 1044 dbSNP
rs1204749985 1047 dbSNP
rs368492930 1052 dbSNP
rs1400050101 1054 dbSNP
rs149593145 1055 dbSNP
rs1477983792 1063 dbSNP
rs906111612 1068 dbSNP
rs567106872 1071 dbSNP
rs544578714 1078 dbSNP
rs983303718 1081 dbSNP
rs1425120002 1091 dbSNP
rs1168204884 1106 dbSNP
rs867675651 1108 dbSNP
rs1179555534 1113 dbSNP
rs1472194144 1117 dbSNP
rs1405538799 1123 dbSNP
rs374545999 1132 dbSNP
rs1011569932 1136 dbSNP
rs1446089042 1141 dbSNP
rs575511762 1148 dbSNP
rs548896793 1151 dbSNP
rs920383379 1157 dbSNP
rs558834322 1161 dbSNP
rs1326313206 1167 dbSNP
rs1224446969 1169 dbSNP
rs1262910188 1169 dbSNP
rs934732587 1177 dbSNP
rs902350114 1183 dbSNP
rs1242384609 1187 dbSNP
rs538509454 1191 dbSNP
rs139351899 1197 dbSNP
rs747889462 1198 dbSNP
rs1175706196 1206 dbSNP
rs1426927802 1214 dbSNP
rs1020643676 1221 dbSNP
rs1010454691 1224 dbSNP
rs892047097 1225 dbSNP
rs1430053202 1231 dbSNP
rs1296439391 1234 dbSNP
rs1199471683 1240 dbSNP
rs1320336264 1243 dbSNP
rs1310875756 1254 dbSNP
rs543609836 1261 dbSNP
rs1379990359 1262 dbSNP
rs1343280396 1268 dbSNP
rs1225873160 1271 dbSNP
rs1286416497 1274 dbSNP
rs1284470960 1275 dbSNP
rs933276532 1279 dbSNP
rs552738260 1289 dbSNP
rs1376626363 1296 dbSNP
rs921840358 1298 dbSNP
rs1467528616 1300 dbSNP
rs1044436615 1306 dbSNP
rs1244952400 1312 dbSNP
rs974406135 1320 dbSNP
rs1158958727 1321 dbSNP
rs941710763 1328 dbSNP
rs1129409 1329 dbSNP
rs1408916883 1330 dbSNP
rs1802379 1331 dbSNP
rs535985544 1332 dbSNP
rs370668561 1338 dbSNP
rs1404179662 1340 dbSNP
rs908850743 1346 dbSNP
rs768422800 1347 dbSNP
rs983614699 1350 dbSNP
rs1157152392 1352 dbSNP
rs1367513776 1355 dbSNP
rs1405674672 1355 dbSNP
rs917213841 1355 dbSNP
rs950458991 1359 dbSNP
rs1035899707 1360 dbSNP
rs1444752002 1371 dbSNP
rs1280516317 1377 dbSNP
rs1372074901 1380 dbSNP
rs1413963112 1381 dbSNP
rs1237491083 1388 dbSNP
rs761872931 1393 dbSNP
rs1293556920 1403 dbSNP
rs530360002 1406 dbSNP
rs56410431 1411 dbSNP
rs1221133339 1414 dbSNP
rs970325658 1421 dbSNP
rs1047722427 1427 dbSNP
rs1437791232 1428 dbSNP
rs1023203867 1436 dbSNP
rs1011806255 1439 dbSNP
rs563299706 1446 dbSNP
rs1437652997 1449 dbSNP
rs1176976128 1451 dbSNP
rs919809531 1452 dbSNP
rs893138574 1453 dbSNP
rs74111051 1454 dbSNP
rs1263836035 1460 dbSNP
rs1425335701 1463 dbSNP
rs781683950 1475 dbSNP
rs1162762264 1484 dbSNP
rs550229468 1488 dbSNP
rs973754898 1490 dbSNP
rs999345492 1500 dbSNP
rs759493161 1504 dbSNP
rs1330217154 1505 dbSNP
rs1354291460 1513 dbSNP
rs891205375 1514 dbSNP
rs1051577275 1517 dbSNP
rs997287286 1521 dbSNP
rs1292203844 1527 dbSNP
rs900322065 1528 dbSNP
rs1238575081 1529 dbSNP
rs530552622 1531 dbSNP
rs1196288767 1533 dbSNP
rs954448915 1537 dbSNP
rs1020758011 1546 dbSNP
rs571112299 1547 dbSNP
rs1245143859 1551 dbSNP
rs1038941537 1552 dbSNP
rs987800478 1558 dbSNP
rs941924291 1578 dbSNP
rs1366791935 1590 dbSNP
rs1476461272 1598 dbSNP
rs769181464 1601 dbSNP
rs1168970016 1607 dbSNP
rs17236120 1609 dbSNP
rs1464347463 1611 dbSNP
rs1365939793 1613 dbSNP
rs1406275866 1614 dbSNP
rs1395089871 1620 dbSNP
rs1047388701 1622 dbSNP
rs1327651610 1628 dbSNP
rs1227567302 1629 dbSNP
rs1435397170 1632 dbSNP
rs1316011880 1634 dbSNP
rs1225057997 1635 dbSNP
rs1263531094 1639 dbSNP
rs929080545 1646 dbSNP
rs1164985019 1648 dbSNP
rs928355612 1665 dbSNP
rs1417347940 1668 dbSNP
rs1033247611 1669 dbSNP
rs1254384215 1676 dbSNP
rs981629755 1682 dbSNP
rs1448770518 1687 dbSNP
rs1379572106 1694 dbSNP
rs1194021377 1696 dbSNP
rs532687105 1698 dbSNP
rs1477132505 1704 dbSNP
rs1441255521 1706 dbSNP
rs1265082211 1711 dbSNP
rs906003413 1717 dbSNP
rs916051162 1720 dbSNP
rs780657392 1723 dbSNP
rs1014252925 1726 dbSNP
rs115069908 1730 dbSNP
rs376103235 1737 dbSNP
rs770804893 1738 dbSNP
rs957603106 1741 dbSNP
rs1032126686 1742 dbSNP
rs998856787 1745 dbSNP
rs749127768 1746 dbSNP
rs1406691573 1748 dbSNP
rs1283912908 1753 dbSNP
rs150886240 1762 dbSNP
rs777266713 1763 dbSNP
rs530251979 1769 dbSNP
rs376782453 1770 dbSNP
rs542013070 1775 dbSNP
rs910352499 1777 dbSNP
rs1487384683 1793 dbSNP
rs1202204168 1797 dbSNP
rs1270281050 1798 dbSNP
rs1432921843 1804 dbSNP
rs181718082 1812 dbSNP
rs758949728 1813 dbSNP
rs987301431 1814 dbSNP
rs1453998469 1834 dbSNP
rs558637805 1836 dbSNP
rs1038804274 1838 dbSNP
rs964515486 1843 dbSNP
rs1426053855 1849 dbSNP
rs1303645747 1855 dbSNP
rs1366850268 1857 dbSNP
rs988322999 1858 dbSNP
rs1308890915 1860 dbSNP
rs1336201545 1864 dbSNP
rs1241138883 1875 dbSNP
rs1006591258 1877 dbSNP
rs190950060 1880 dbSNP
rs957705633 1883 dbSNP
rs887693081 1884 dbSNP
rs1298723189 1892 dbSNP
rs1032438723 1902 dbSNP
rs747605006 1904 dbSNP
rs1293072349 1912 dbSNP
rs1488446515 1919 dbSNP
rs1189772998 1920 dbSNP
rs745880260 1924 dbSNP
rs780738472 1927 dbSNP
rs1177599996 1929 dbSNP
rs970717612 1934 dbSNP
rs1023211549 1939 dbSNP
rs1349165479 1940 dbSNP
rs1456327538 1941 dbSNP
rs1299877273 1948 dbSNP
rs1396921642 1951 dbSNP
rs141569623 1955 dbSNP
rs572795705 1959 dbSNP
rs896014040 1962 dbSNP
rs1374978389 1964 dbSNP
rs552773395 1972 dbSNP
rs1313534567 1973 dbSNP
rs139302493 1975 dbSNP
rs1458464976 1976 dbSNP
rs994006723 1978 dbSNP
rs567097555 1981 dbSNP
rs899136499 1983 dbSNP
rs1482590224 1985 dbSNP
rs916082227 1989 dbSNP
rs990329599 1992 dbSNP
rs1421600166 2000 dbSNP
rs1376031830 2004 dbSNP
rs1314315099 2010 dbSNP
rs1284743336 2011 dbSNP
rs957888776 2013 dbSNP
rs889029854 2014 dbSNP
rs1398293157 2019 dbSNP
rs750890540 2046 dbSNP
rs879458292 2051 dbSNP
rs1303699545 2053 dbSNP
rs147326269 2054 dbSNP
rs544350115 2058 dbSNP
rs779421069 2059 dbSNP
rs1298308415 2063 dbSNP
rs1319231742 2067 dbSNP
rs1218335995 2069 dbSNP
rs1383831641 2070 dbSNP
rs8676 2088 dbSNP
rs1029585429 2089 dbSNP
rs571262744 2094 dbSNP
rs996890816 2096 dbSNP
rs8458 2097 dbSNP
rs1408097988 2102 dbSNP
rs1187784358 2108 dbSNP
rs1017889783 2113 dbSNP
rs924934096 2115 dbSNP
rs1424397322 2121 dbSNP
rs532870032 2123 dbSNP
rs1431137212 2132 dbSNP
rs1195355110 2134 dbSNP
rs1470169198 2141 dbSNP
rs1006039851 2146 dbSNP
rs3790681 2148 dbSNP
rs1445839002 2150 dbSNP
rs1290717101 2158 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM545212. RNA binding protein: AGO1. Condition:Control PAR-CLIP data was present in GSM545213. RNA binding protein: AGO2. Condition:Control PAR-CLIP data was present in GSM545214. RNA binding protein: AGO3. Condition:Control ...

- Hafner M; Landthaler M; Burger L; Khorshid et al., 2010, Cell.

Article - Hafner M; Landthaler M; Burger L; Khorshid et al.
- Cell, 2010
RNA transcripts are subject to posttranscriptional gene regulation involving hundreds of RNA-binding proteins (RBPs) and microRNA-containing ribonucleoprotein complexes (miRNPs) expressed in a cell-type dependent fashion. We developed a cell-based crosslinking approach to determine at high resolution and transcriptome-wide the binding sites of cellular RBPs and miRNPs. The crosslinked sites are revealed by thymidine to cytidine transitions in the cDNAs prepared from immunopurified RNPs of 4-thiouridine-treated cells. We determined the binding sites and regulatory consequences for several intensely studied RBPs and miRNPs, including PUM2, QKI, IGF2BP1-3, AGO/EIF2C1-4 and TNRC6A-C. Our study revealed that these factors bind thousands of sites containing defined sequence motifs and have distinct preferences for exonic versus intronic or coding versus untranslated transcript regions. The precise mapping of binding sites across the transcriptome will be critical to the interpretation of the rapidly emerging data on genetic variation between individuals and how these variations contribute to complex genetic diseases.
LinkOut: [PMID: 20371350]
Experimental Support 2 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions C8166 , TZM-bl
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM1462572. RNA binding protein: AGO2. Condition:C8166 NL4-3 PAR-CLIP data was present in GSM1462573. RNA binding protein: AGO2. Condition:TZM-bl BaL PAR-CLIP data was present in GSM1462574. RNA binding protein: AGO2. Condition:TZM-bl ami BaL ...

- Whisnant AW; Bogerd HP; Flores O; Ho P; et al., 2013, mBio.

Article - Whisnant AW; Bogerd HP; Flores O; Ho P; et al.
- mBio, 2013
UNLABELLED: The question of how HIV-1 interfaces with cellular microRNA (miRNA) biogenesis and effector mechanisms has been highly controversial. Here, we first used deep sequencing of small RNAs present in two different infected cell lines (TZM-bl and C8166) and two types of primary human cells (CD4(+) peripheral blood mononuclear cells [PBMCs] and macrophages) to unequivocally demonstrate that HIV-1 does not encode any viral miRNAs. Perhaps surprisingly, we also observed that infection of T cells by HIV-1 has only a modest effect on the expression of cellular miRNAs at early times after infection. Comprehensive analysis of miRNA binding to the HIV-1 genome using the photoactivatable ribonucleoside-induced cross-linking and immunoprecipitation (PAR-CLIP) technique revealed several binding sites for cellular miRNAs, a subset of which were shown to be capable of mediating miRNA-mediated repression of gene expression. However, the main finding from this analysis is that HIV-1 transcripts are largely refractory to miRNA binding, most probably due to extensive viral RNA secondary structure. Together, these data demonstrate that HIV-1 neither encodes viral miRNAs nor strongly influences cellular miRNA expression, at least early after infection, and imply that HIV-1 transcripts have evolved to avoid inhibition by preexisting cellular miRNAs by adopting extensive RNA secondary structures that occlude most potential miRNA binding sites. IMPORTANCE: MicroRNAs (miRNAs) are a ubiquitous class of small regulatory RNAs that serve as posttranscriptional regulators of gene expression. Previous work has suggested that HIV-1 might subvert the function of the cellular miRNA machinery by expressing viral miRNAs or by dramatically altering the level of cellular miRNA expression. Using very sensitive approaches, we now demonstrate that neither of these ideas is in fact correct. Moreover, HIV-1 transcripts appear to largely avoid regulation by cellular miRNAs by adopting an extensive RNA secondary structure that occludes the ability of cellular miRNAs to interact with viral mRNAs. Together, these data suggest that HIV-1, rather than seeking to control miRNA function in infected cells, has instead evolved a mechanism to become largely invisible to cellular miRNA effector mechanisms.
LinkOut: [PMID: 23592263]
Experimental Support 3 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HCT116
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in ERX177599. RNA binding protein: AGO2. Condition:p53_D_AGO_CLIP_2_1 PAR-CLIP data was present in ERX177602. RNA binding protein: AGO2. Condition:KO_V_AGO_CLIP_2_4 PAR-CLIP data was present in ERX177609. RNA binding protein: AGO2. Condition:KO_D_AGO_CLIP_2_11 PAR-CLIP data was present in ERX177610. RNA binding protein: AGO2. Condition:KO_V_AGO_CLIP_2_12 PAR-CLIP data was present in ERX177614. RNA binding protein: AGO2. Condition:KO_V_AGO_CLIP_3_4 PAR-CLIP data was present in ERX177618. RNA binding protein: AGO2. Condition:KO_V_AGO_CLIP_3_8 PAR-CLIP data was present in ERX177622. RNA binding protein: AGO2. Condition:KO_V_AGO_CLIP_3_12 PAR-CLIP data was present in ERX177633. RNA binding protein: AGO2. Condition:KO_D_AGO_CLIP_4_11 PAR-CLIP data was present in ERX177634. RNA binding protein: AGO2. Condition:KO_V_AGO_CLIP_4_12 PAR-CLIP data was present in ERX177603. RNA binding protein: AGO2. Condition:p53_D_AGO_CLIP_2_5 PAR-CLIP data was present in ERX177606. RNA binding protein: AGO2. Condition:KO_V_AGO_CLIP_2_8 PAR-CLIP data was present in ERX177623. RNA binding protein: AGO2. Condition:p53_D_AGO_CLIP_4_1 PAR-CLIP data was present in ERX177627. RNA binding protein: AGO2. Condition:p53_D_AGO_CLIP_4_5 PAR-CLIP data was present in ERX177605. RNA binding protein: AGO2. Condition:KO_D_AGO_CLIP_2_7 PAR-CLIP data was present in ERX177608. RNA binding protein: AGO2. Condition:p53_V_AGO_CLIP_2_10 PAR-CLIP data was present in ERX177620. RNA binding protein: AGO2. Condition:p53_V_AGO_CLIP_3_10 PAR-CLIP data was present in ERX177629. RNA binding protein: AGO2. Condition:KO_D_AGO_CLIP_4_7 PAR-CLIP data was present in ERX177630. RNA binding protein: AGO2. Condition:KO_V_AGO_CLIP_4_8 PAR-CLIP data was present in ERX177632. RNA binding protein: AGO2. Condition:p53_V_AGO_CLIP_4_10 PAR-CLIP data was present in ERX177611. RNA binding protein: AGO2. Condition:p53_D_AGO_CLIP_3_1 PAR-CLIP data was present in ERX177607. RNA binding protein: AGO2. Condition:p53_D_AGO_CLIP_2_9 PAR-CLIP data was present in ERX177615. RNA binding protein: AGO2. Condition:p53_D_AGO_CLIP_3_5 PAR-CLIP data was present in ERX177619. RNA binding protein: AGO2. Condition:p53_D_AGO_CLIP_3_9 PAR-CLIP data was present in ERX177631. RNA binding protein: AGO2. Condition:p53_D_AGO_CLIP_4_9 ...

- Krell J; Stebbing J; Carissimi C; Dabrowska et al., 2016, Genome research.

Article - Krell J; Stebbing J; Carissimi C; Dabrowska et al.
- Genome research, 2016
DNA damage activates TP53-regulated surveillance mechanisms that are crucial in suppressing tumorigenesis. TP53 orchestrates these responses directly by transcriptionally modulating genes, including microRNAs (miRNAs), and by regulating miRNA biogenesis through interacting with the DROSHA complex. However, whether the association between miRNAs and AGO2 is regulated following DNA damage is not yet known. Here, we show that, following DNA damage, TP53 interacts with AGO2 to induce or reduce AGO2's association of a subset of miRNAs, including multiple let-7 family members. Furthermore, we show that specific mutations in TP53 decrease rather than increase the association of let-7 family miRNAs, reducing their activity without preventing TP53 from interacting with AGO2. This is consistent with the oncogenic properties of these mutants. Using AGO2 RIP-seq and PAR-CLIP-seq, we show that the DNA damage-induced increase in binding of let-7 family members to the RISC complex is functional. We unambiguously determine the global miRNA-mRNA interaction networks involved in the DNA damage response, validating them through the identification of miRNA-target chimeras formed by endogenous ligation reactions. We find that the target complementary region of the let-7 seed tends to have highly fixed positions and more variable ones. Additionally, we observe that miRNAs, whose cellular abundance or differential association with AGO2 is regulated by TP53, are involved in an intricate network of regulatory feedback and feedforward circuits. TP53-mediated regulation of AGO2-miRNA interaction represents a new mechanism of miRNA regulation in carcinogenesis.
LinkOut: [PMID: 26701625]
Experimental Support 4 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions Prostate Tissue
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in SRX1760618. RNA binding protein: AGO2. Condition:AGO-CLIP-PC3_B PAR-CLIP data was present in SRX1760631. RNA binding protein: AGO2. Condition:AGO-CLIP-22RV1_B PAR-CLIP data was present in SRX1760620. RNA binding protein: AGO2. Condition:AGO-CLIP-LAPC4_A PAR-CLIP data was present in SRX1760628. RNA binding protein: AGO2. Condition:AGO-CLIP-LAPC4_B PAR-CLIP data was present in SRX1760638. RNA binding protein: AGO2. Condition:AGO-CLIP-PC3-miR148 PAR-CLIP data was present in SRX1760639. RNA binding protein: AGO2. Condition:AGO-CLIP-LNCaP-MDV_A PAR-CLIP data was present in SRX1760641. RNA binding protein: AGO2. Condition:AGO-CLIP-LNCaP-MDV_B PAR-CLIP data was present in SRX1760630. RNA binding protein: AGO2. Condition:AGO-CLIP-22RV1_A PAR-CLIP data was present in SRX1760583. RNA binding protein: AGO2. Condition:AGO-CLIP-LNCaP_A PAR-CLIP data was present in SRX1760591. RNA binding protein: AGO2. Condition:AGO-CLIP-LNCaP_B PAR-CLIP data was present in SRX1760632. RNA binding protein: AGO2. Condition:AGO-CLIP-22RV1_C ...

- Hamilton MP; Rajapakshe KI; Bader DA; Cerne et al., 2016, Neoplasia (New York, N.Y.).

Article - Hamilton MP; Rajapakshe KI; Bader DA; Cerne et al.
- Neoplasia (New York, N.Y.), 2016
MicroRNA (miRNA) deregulation in prostate cancer (PCa) contributes to PCa initiation and metastatic progression. To comprehensively define the cancer-associated changes in miRNA targeting and function in commonly studied models of PCa, we performed photoactivatable ribonucleoside-enhanced cross-linking immunoprecipitation of the Argonaute protein in a panel of PCa cell lines modeling different stages of PCa progression. Using this comprehensive catalogue of miRNA targets, we analyzed miRNA targeting on known drivers of PCa and examined tissue-specific and stage-specific pathway targeting by miRNAs. We found that androgen receptor is the most frequently targeted PCa oncogene and that miR-148a targets the largest number of known PCa drivers. Globally, tissue-specific and stage-specific changes in miRNA targeting are driven by homeostatic response to active oncogenic pathways. Our findings indicate that, even in advanced PCa, the miRNA pool adapts to regulate continuing alterations in the cancer genome to balance oncogenic molecular changes. These findings are important because they are the first to globally characterize miRNA changes in PCa and demonstrate how the miRNA target spectrum responds to staged tumorigenesis.
LinkOut: [PMID: 27292025]
CLIP-seq Support 1 for dataset GSM545212
Method / RBP PAR-CLIP / AGO1
Cell line / Condition HEK293 / Control
Location of target site ENST00000370056.4 | 3UTR | GUAGGAGGGCCGCUGCGGUGAGUCUUGAAGCCCA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 20371350 / GSE21578
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM545213
Method / RBP PAR-CLIP / AGO2
Cell line / Condition HEK293 / Control
Location of target site ENST00000370056.4 | 3UTR | UAGGAGGGCCGCUGCGGUGAGUCUUGAAGC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 20371350 / GSE21578
CLIP-seq Viewer Link
CLIP-seq Support 3 for dataset GSM545214
Method / RBP PAR-CLIP / AGO3
Cell line / Condition HEK293 / Control
Location of target site ENST00000370056.4 | 3UTR | AGUAGGAGGGCCGCUGCGGUGAGUCUUGAAGCCCAG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 20371350 / GSE21578
CLIP-seq Viewer Link
CLIP-seq Support 4 for dataset GSM1462572
Method / RBP PAR-CLIP / AGO2
Cell line / Condition C8166 / C8166 NL4-3
Location of target site ENST00000370056.4 | 3UTR | AGUAGGAGGGCCGCUGCGGUGAGUCUUGAAGCCCAGGGC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23592263 / GSE59944
CLIP-seq Viewer Link
CLIP-seq Support 5 for dataset GSM1462573
Method / RBP PAR-CLIP / AGO2
Cell line / Condition TZM-bl / TZM-bl BaL
Location of target site ENST00000370056.4 | 3UTR | AGUAGGAGGGCCGCUGCGGUGAGUCUUGAAGCCCAGGGC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23592263 / GSE59944
CLIP-seq Viewer Link
CLIP-seq Support 6 for dataset GSM1462574
Method / RBP PAR-CLIP / AGO2
Cell line / Condition TZM-bl / TZM-bl ami BaL
Location of target site ENST00000370056.4 | 3UTR | CUAGUAGGAGGGCCGCUGCGGUGAGUCUUGAAGCCCAGGGC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23592263 / GSE59944
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
330 hsa-miR-939-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT247374 GABARAPL1 GABA type A receptor associated protein like 1 2 2
MIRT304947 CNBP CCHC-type zinc finger nucleic acid binding protein 2 2
MIRT444448 PLCXD2 phosphatidylinositol specific phospholipase C X domain containing 2 2 2
MIRT446613 HIP1 huntingtin interacting protein 1 2 2
MIRT447114 CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit 2 2
MIRT454832 POLR2J3 RNA polymerase II subunit J3 2 2
MIRT456105 VAV3 vav guanine nucleotide exchange factor 3 2 4
MIRT457626 UPK3BL uroplakin 3B like 1 2 2
MIRT465224 TRIP10 thyroid hormone receptor interactor 10 2 2
MIRT465262 TRIM44 tripartite motif containing 44 2 2
MIRT467963 SLC16A1 solute carrier family 16 member 1 2 2
MIRT471841 NUFIP2 NUFIP2, FMR1 interacting protein 2 2 2
MIRT473978 LRRC58 leucine rich repeat containing 58 2 2
MIRT475231 IKZF3 IKAROS family zinc finger 3 2 6
MIRT478536 CTNS cystinosin, lysosomal cystine transporter 2 2
MIRT480102 CALR calreticulin 2 2
MIRT480299 C7orf73 short transmembrane mitochondrial protein 1 2 4
MIRT481159 AVL9 AVL9 cell migration associated 2 2
MIRT481232 ATXN7L3 ataxin 7 like 3 2 2
MIRT481975 AMOTL2 angiomotin like 2 2 2
MIRT483036 KHSRP KH-type splicing regulatory protein 2 4
MIRT485632 EEPD1 endonuclease/exonuclease/phosphatase family domain containing 1 2 2
MIRT487115 SCARF2 scavenger receptor class F member 2 2 2
MIRT489897 PPIC peptidylprolyl isomerase C 2 4
MIRT490804 PSMD3 proteasome 26S subunit, non-ATPase 3 2 2
MIRT492561 PRX periaxin 2 6
MIRT493012 NANOS1 nanos C2HC-type zinc finger 1 2 2
MIRT494470 BTF3L4 basic transcription factor 3 like 4 2 6
MIRT495063 PADI3 peptidyl arginine deiminase 3 2 4
MIRT496484 ADAMTS17 ADAM metallopeptidase with thrombospondin type 1 motif 17 2 2
MIRT497181 ZBTB40 zinc finger and BTB domain containing 40 2 2
MIRT505026 ZNF460 zinc finger protein 460 2 6
MIRT506174 PIK3R1 phosphoinositide-3-kinase regulatory subunit 1 2 4
MIRT507299 FEM1B fem-1 homolog B 2 2
MIRT516318 F8A2 coagulation factor VIII associated 2 2 2
MIRT516344 F8A3 coagulation factor VIII associated 3 2 2
MIRT517817 UGDH UDP-glucose 6-dehydrogenase 2 6
MIRT518748 C1orf35 chromosome 1 open reading frame 35 2 2
MIRT519301 MLH1 mutL homolog 1 2 2
MIRT528565 DNAAF3 dynein axonemal assembly factor 3 2 2
MIRT528719 S100A2 S100 calcium binding protein A2 2 2
MIRT531524 NOM1 nucleolar protein with MIF4G domain 1 2 2
MIRT534547 RUNX1 runt related transcription factor 1 2 2
MIRT539566 CNKSR3 CNKSR family member 3 2 4
MIRT539596 SSH2 slingshot protein phosphatase 2 2 2
MIRT539680 ZBTB44 zinc finger and BTB domain containing 44 2 2
MIRT539713 EIF3H eukaryotic translation initiation factor 3 subunit H 2 2
MIRT539734 DNAH10OS dynein axonemal heavy chain 10 opposite strand 2 2
MIRT539792 EMC1 ER membrane protein complex subunit 1 2 4
MIRT539819 GAPVD1 GTPase activating protein and VPS9 domains 1 2 2
MIRT539998 SLC24A4 solute carrier family 24 member 4 2 2
MIRT540042 DNAJC28 DnaJ heat shock protein family (Hsp40) member C28 2 4
MIRT540078 SSH3 slingshot protein phosphatase 3 2 2
MIRT540096 NPY4R neuropeptide Y receptor Y4 2 2
MIRT540231 SAMD5 sterile alpha motif domain containing 5 2 2
MIRT540250 RGS17 regulator of G protein signaling 17 2 2
MIRT540323 PIGR polymeric immunoglobulin receptor 2 2
MIRT540431 FAM83F family with sequence similarity 83 member F 2 2
MIRT540515 CXCL10 C-X-C motif chemokine ligand 10 2 2
MIRT540535 ZNF417 zinc finger protein 417 2 2
MIRT540626 F2RL2 coagulation factor II thrombin receptor like 2 2 2
MIRT540879 ZBTB24 zinc finger and BTB domain containing 24 2 2
MIRT540896 SRSF9 serine and arginine rich splicing factor 9 2 2
MIRT540914 PON1 paraoxonase 1 2 2
MIRT541334 G3BP1 G3BP stress granule assembly factor 1 2 2
MIRT541517 TOR1AIP1 torsin 1A interacting protein 1 2 2
MIRT541569 ZNF43 zinc finger protein 43 2 4
MIRT541636 PARP2 poly(ADP-ribose) polymerase 2 2 2
MIRT541670 ATP8B3 ATPase phospholipid transporting 8B3 2 2
MIRT541741 ZC3HAV1 zinc finger CCCH-type containing, antiviral 1 2 2
MIRT541789 TBCCD1 TBCC domain containing 1 2 2
MIRT541818 SMU1 DNA replication regulator and spliceosomal factor 2 2
MIRT541855 PLIN5 perilipin 5 2 2
MIRT541910 VWA7 von Willebrand factor A domain containing 7 2 2
MIRT541929 ORC1 origin recognition complex subunit 1 2 4
MIRT542009 XRCC2 X-ray repair cross complementing 2 2 4
MIRT542023 PEX2 peroxisomal biogenesis factor 2 2 2
MIRT542192 FUT1 fucosyltransferase 1 (H blood group) 2 6
MIRT542210 C14orf142 GON7, KEOPS complex subunit homolog 2 2
MIRT542237 FUT9 fucosyltransferase 9 2 2
MIRT542288 POLR3K RNA polymerase III subunit K 2 2
MIRT542305 QTRTD1 queuine tRNA-ribosyltransferase accessory subunit 2 2 4
MIRT542343 LIMD1 LIM domains containing 1 2 2
MIRT542371 PAICS phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase 2 2
MIRT542430 ZNF331 zinc finger protein 331 2 2
MIRT542445 C3 complement C3 2 4
MIRT542462 AKR7A2 aldo-keto reductase family 7 member A2 2 2
MIRT542479 APOC3 apolipoprotein C3 2 2
MIRT542500 WDR13 WD repeat domain 13 2 2
MIRT542537 MRPS10 mitochondrial ribosomal protein S10 2 2
MIRT542643 TIMM8A translocase of inner mitochondrial membrane 8A 2 4
MIRT542707 RPS15A ribosomal protein S15a 2 2
MIRT542794 PLEKHA3 pleckstrin homology domain containing A3 2 2
MIRT542824 PDE12 phosphodiesterase 12 2 2
MIRT546235 TNRC18P2 trinucleotide repeat containing 18 pseudogene 2 2 4
MIRT550023 BAG1 BCL2 associated athanogene 1 2 2
MIRT551434 F2 coagulation factor II, thrombin 2 2
MIRT558613 COX6B1 cytochrome c oxidase subunit 6B1 2 2
MIRT559747 ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 2 2
MIRT572272 AGO2 argonaute 2, RISC catalytic component 2 2
MIRT572605 PAPLN papilin, proteoglycan like sulfated glycoprotein 2 2
MIRT573603 CERS1 ceramide synthase 1 2 2
MIRT574124 CDCP1 CUB domain containing protein 1 2 2
MIRT607392 LANCL3 LanC like 3 2 2
MIRT607454 ZNF543 zinc finger protein 543 2 2
MIRT608706 GMPR guanosine monophosphate reductase 2 2
MIRT615269 ZNF488 zinc finger protein 488 2 2
MIRT616105 HOXB5 homeobox B5 2 2
MIRT617344 ZSCAN2 zinc finger and SCAN domain containing 2 2 2
MIRT617386 FAM227A family with sequence similarity 227 member A 2 2
MIRT617710 RUSC2 RUN and SH3 domain containing 2 2 2
MIRT620892 ANO7 anoctamin 7 2 2
MIRT621222 LILRA2 leukocyte immunoglobulin like receptor A2 2 2
MIRT622088 SRPX2 sushi repeat containing protein, X-linked 2 2 2
MIRT622545 PXMP4 peroxisomal membrane protein 4 2 2
MIRT622659 POU2F3 POU class 2 homeobox 3 2 4
MIRT623876 FUS FUS RNA binding protein 2 2
MIRT624566 BDP1 B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB 2 2
MIRT626370 DIS3L DIS3 like exosome 3'-5' exoribonuclease 2 2
MIRT629258 KDM2B lysine demethylase 2B 2 2
MIRT630774 MSANTD3 Myb/SANT DNA binding domain containing 3 2 2
MIRT631311 CBS cystathionine-beta-synthase 2 2
MIRT631874 BBS5 Bardet-Biedl syndrome 5 2 2
MIRT631909 VEGFC vascular endothelial growth factor C 2 2
MIRT632880 GOSR1 golgi SNAP receptor complex member 1 2 2
MIRT632944 ELOVL6 ELOVL fatty acid elongase 6 2 4
MIRT633137 C6orf132 chromosome 6 open reading frame 132 2 2
MIRT633994 SLC35E2 solute carrier family 35 member E2 2 2
MIRT634887 SENP8 SUMO/sentrin peptidase family member, NEDD8 specific 2 2
MIRT635285 GK5 glycerol kinase 5 (putative) 2 2
MIRT635347 RBL1 RB transcriptional corepressor like 1 2 2
MIRT635868 SLC11A2 solute carrier family 11 member 2 2 2
MIRT636634 CHAF1B chromatin assembly factor 1 subunit B 2 4
MIRT636959 APTX aprataxin 2 2
MIRT637482 DEFB105B defensin beta 105B 2 4
MIRT637514 DEFB105A defensin beta 105A 2 4
MIRT637811 GGPS1 geranylgeranyl diphosphate synthase 1 2 2
MIRT638473 PANK3 pantothenate kinase 3 2 2
MIRT638629 GSR glutathione-disulfide reductase 2 4
MIRT640401 ZNF785 zinc finger protein 785 2 2
MIRT640881 ENTPD1 ectonucleoside triphosphate diphosphohydrolase 1 2 2
MIRT641017 ANKFY1 ankyrin repeat and FYVE domain containing 1 2 2
MIRT641933 SLC25A16 solute carrier family 25 member 16 2 2
MIRT642204 SMAGP small cell adhesion glycoprotein 2 2
MIRT642446 CLUAP1 clusterin associated protein 1 2 2
MIRT642857 RNF135 ring finger protein 135 2 2
MIRT643024 LETM2 leucine zipper and EF-hand containing transmembrane protein 2 2 2
MIRT643245 PRSS21 protease, serine 21 2 2
MIRT643380 TRIM16L tripartite motif containing 16 like 2 2
MIRT645127 HES2 hes family bHLH transcription factor 2 2 2
MIRT645652 MRPS16 mitochondrial ribosomal protein S16 2 2
MIRT646045 NPR1 natriuretic peptide receptor 1 2 2
MIRT646085 MGST3 microsomal glutathione S-transferase 3 2 2
MIRT646569 ALDH5A1 aldehyde dehydrogenase 5 family member A1 2 2
MIRT646934 MCCC2 methylcrotonoyl-CoA carboxylase 2 2 2
MIRT647789 ASB8 ankyrin repeat and SOCS box containing 8 2 2
MIRT647808 FRMD8 FERM domain containing 8 2 2
MIRT648093 FAM192A family with sequence similarity 192 member A 2 2
MIRT648675 ZNF626 zinc finger protein 626 2 2
MIRT648979 ACAD8 acyl-CoA dehydrogenase family member 8 2 2
MIRT649307 IGSF6 immunoglobulin superfamily member 6 2 2
MIRT651397 ZBTB16 zinc finger and BTB domain containing 16 2 2
MIRT651826 USP49 ubiquitin specific peptidase 49 2 2
MIRT652479 TMEM181 transmembrane protein 181 2 2
MIRT652841 TACO1 translational activator of cytochrome c oxidase I 2 2
MIRT653029 STX1B syntaxin 1B 2 2
MIRT654767 PRKAR2A protein kinase cAMP-dependent type II regulatory subunit alpha 2 2
MIRT655208 PHAX phosphorylated adaptor for RNA export 2 2
MIRT655594 OTUD7B OTU deubiquitinase 7B 2 2
MIRT655898 NEK9 NIMA related kinase 9 2 2
MIRT656566 LYRM7 LYR motif containing 7 2 2
MIRT657656 GPR75 G protein-coupled receptor 75 2 2
MIRT657817 GJD3 gap junction protein delta 3 2 2
MIRT658699 EMC3 ER membrane protein complex subunit 3 2 2
MIRT660739 ALG14 ALG14, UDP-N-acetylglucosaminyltransferase subunit 2 2
MIRT660993 ABHD2 abhydrolase domain containing 2 2 2
MIRT661178 S1PR2 sphingosine-1-phosphate receptor 2 2 2
MIRT661337 TBC1D15 TBC1 domain family member 15 2 2
MIRT661825 PRPSAP1 phosphoribosyl pyrophosphate synthetase associated protein 1 2 2
MIRT662014 ZNF445 zinc finger protein 445 2 2
MIRT663048 SLC16A4 solute carrier family 16 member 4 2 2
MIRT663355 ORAI2 ORAI calcium release-activated calcium modulator 2 2 2
MIRT663478 POFUT2 protein O-fucosyltransferase 2 2 2
MIRT665027 ELK1 ELK1, ETS transcription factor 2 2
MIRT665164 SF3A1 splicing factor 3a subunit 1 2 4
MIRT665588 TUBD1 tubulin delta 1 2 2
MIRT666463 SCRG1 stimulator of chondrogenesis 1 2 2
MIRT666526 RNF170 ring finger protein 170 2 2
MIRT666548 RNF115 ring finger protein 115 2 2
MIRT666971 PI4K2B phosphatidylinositol 4-kinase type 2 beta 2 2
MIRT667281 NAV1 neuron navigator 1 2 2
MIRT667294 MYPN myopalladin 2 4
MIRT668025 HAUS3 HAUS augmin like complex subunit 3 2 2
MIRT668154 GDE1 glycerophosphodiester phosphodiesterase 1 2 2
MIRT668335 FKBP5 FK506 binding protein 5 2 2
MIRT669309 C17orf75 chromosome 17 open reading frame 75 2 2
MIRT669352 BMP3 bone morphogenetic protein 3 2 2
MIRT669731 ZBTB8B zinc finger and BTB domain containing 8B 2 4
MIRT670093 ABCF3 ATP binding cassette subfamily F member 3 2 4
MIRT671687 ADK adenosine kinase 2 2
MIRT673234 KLHDC8A kelch domain containing 8A 2 2
MIRT673616 HPSE heparanase 2 2
MIRT673762 ZNF333 zinc finger protein 333 2 2
MIRT674816 FAM229B family with sequence similarity 229 member B 2 2
MIRT675136 ZNF347 zinc finger protein 347 2 2
MIRT675300 ARL10 ADP ribosylation factor like GTPase 10 2 2
MIRT675403 SVOP SV2 related protein 2 2
MIRT675636 HACE1 HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1 2 2
MIRT675792 MED28 mediator complex subunit 28 2 2
MIRT676570 VSIG1 V-set and immunoglobulin domain containing 1 2 2
MIRT676722 METTL14 methyltransferase like 14 2 2
MIRT676812 SHROOM4 shroom family member 4 2 2
MIRT677090 SMIM15 small integral membrane protein 15 2 2
MIRT677203 MURC caveolae associated protein 4 2 2
MIRT677283 SNRPD1 small nuclear ribonucleoprotein D1 polypeptide 2 2
MIRT677358 POC1A POC1 centriolar protein A 2 2
MIRT677515 SLC10A6 solute carrier family 10 member 6 2 2
MIRT677529 OCIAD2 OCIA domain containing 2 2 2
MIRT677626 ALG1 ALG1, chitobiosyldiphosphodolichol beta-mannosyltransferase 2 2
MIRT677668 UGGT1 UDP-glucose glycoprotein glucosyltransferase 1 2 2
MIRT677806 PNPLA3 patatin like phospholipase domain containing 3 2 2
MIRT677946 ZNF519 zinc finger protein 519 2 2
MIRT678150 SLC4A4 solute carrier family 4 member 4 2 2
MIRT678208 CSNK1E casein kinase 1 epsilon 2 2
MIRT678379 VTA1 vesicle trafficking 1 2 2
MIRT678628 OLFML2A olfactomedin like 2A 2 2
MIRT678712 DHTKD1 dehydrogenase E1 and transketolase domain containing 1 2 2
MIRT678793 NUPL2 nucleoporin like 2 2 2
MIRT678973 OGFOD1 2-oxoglutarate and iron dependent oxygenase domain containing 1 2 2
MIRT679042 LACTB lactamase beta 2 2
MIRT679087 PURB purine rich element binding protein B 2 2
MIRT679140 SYK spleen associated tyrosine kinase 2 2
MIRT679306 SSBP2 single stranded DNA binding protein 2 2 2
MIRT679564 LIN9 lin-9 DREAM MuvB core complex component 2 2
MIRT679749 CABP4 calcium binding protein 4 2 2
MIRT679858 GTDC1 glycosyltransferase like domain containing 1 2 2
MIRT679953 AS3MT arsenite methyltransferase 2 2
MIRT679982 E2F2 E2F transcription factor 2 2 2
MIRT680400 OXA1L OXA1L, mitochondrial inner membrane protein 2 2
MIRT681034 AAED1 AhpC/TSA antioxidant enzyme domain containing 1 2 2
MIRT681727 KCNE4 potassium voltage-gated channel subfamily E regulatory subunit 4 2 2
MIRT682301 RBM28 RNA binding motif protein 28 2 2
MIRT682483 LIX1L limb and CNS expressed 1 like 2 2
MIRT682569 EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1 2 2
MIRT682761 MDM2 MDM2 proto-oncogene 2 2
MIRT682813 TMCO1 transmembrane and coiled-coil domains 1 2 2
MIRT682869 C9orf156 tRNA methyltransferase O 2 2
MIRT682918 FAM73A mitoguardin 1 2 2
MIRT682937 ZNF292 zinc finger protein 292 2 2
MIRT682955 RPL12 ribosomal protein L12 2 2
MIRT682974 NF2 neurofibromin 2 2 2
MIRT683035 SUSD5 sushi domain containing 5 2 2
MIRT683910 PSMB9 proteasome subunit beta 9 2 2
MIRT684182 MOG myelin oligodendrocyte glycoprotein 2 2
MIRT684237 C20orf144 chromosome 20 open reading frame 144 2 2
MIRT684391 MCTS1 MCTS1, re-initiation and release factor 2 2
MIRT684690 OR7D2 olfactory receptor family 7 subfamily D member 2 2 2
MIRT685410 C1orf158 chromosome 1 open reading frame 158 2 2
MIRT687206 PLXNA3 plexin A3 2 2
MIRT687496 NFATC2IP nuclear factor of activated T-cells 2 interacting protein 2 2
MIRT687521 NCKAP1 NCK associated protein 1 2 2
MIRT688249 FITM2 fat storage inducing transmembrane protein 2 2 2
MIRT688323 FAM151B family with sequence similarity 151 member B 2 2
MIRT688743 CNDP1 carnosine dipeptidase 1 2 2
MIRT689039 ANGPTL3 angiopoietin like 3 2 2
MIRT689150 IRAK1BP1 interleukin 1 receptor associated kinase 1 binding protein 1 2 2
MIRT689236 RPS19 ribosomal protein S19 2 2
MIRT689308 C5AR2 complement component 5a receptor 2 2 2
MIRT689366 ZNF101 zinc finger protein 101 2 2
MIRT689657 RBM23 RNA binding motif protein 23 2 2
MIRT690152 PPIL6 peptidylprolyl isomerase like 6 2 2
MIRT690603 C17orf105 chromosome 17 open reading frame 105 2 2
MIRT690807 FAHD1 fumarylacetoacetate hydrolase domain containing 1 2 2
MIRT690948 GLG1 golgi glycoprotein 1 2 2
MIRT691410 DNA2 DNA replication helicase/nuclease 2 2 2
MIRT692237 ALDH1B1 aldehyde dehydrogenase 1 family member B1 2 2
MIRT692524 PARD3 par-3 family cell polarity regulator 2 2
MIRT693626 CENPL centromere protein L 2 2
MIRT693762 ZNF383 zinc finger protein 383 2 2
MIRT694020 PPIL4 peptidylprolyl isomerase like 4 2 2
MIRT694323 NLRP9 NLR family pyrin domain containing 9 2 2
MIRT694598 AAR2 AAR2 splicing factor homolog 2 2
MIRT694812 STX4 syntaxin 4 2 2
MIRT694931 ANKS4B ankyrin repeat and sterile alpha motif domain containing 4B 2 2
MIRT694986 PLAC8 placenta specific 8 2 2
MIRT695022 MRPS21 mitochondrial ribosomal protein S21 2 2
MIRT696222 LYZ lysozyme 2 2
MIRT696419 DOCK7 dedicator of cytokinesis 7 2 2
MIRT697234 ZYG11A zyg-11 family member A, cell cycle regulator 2 2
MIRT697808 UBXN2A UBX domain protein 2A 2 2
MIRT697946 TVP23C trans-golgi network vesicle protein 23 homolog C 2 2
MIRT698511 TGFBR1 transforming growth factor beta receptor 1 2 2
MIRT699536 SIX4 SIX homeobox 4 2 2
MIRT699865 SAR1A secretion associated Ras related GTPase 1A 2 2
MIRT700488 PTPRF protein tyrosine phosphatase, receptor type F 2 2
MIRT702459 KIAA1467 family with sequence similarity 234 member B 2 2
MIRT702616 ITPRIPL2 inositol 1,4,5-trisphosphate receptor interacting protein like 2 2 2
MIRT702693 IRGQ immunity related GTPase Q 2 2
MIRT702937 HMX3 H6 family homeobox 3 2 2
MIRT702993 HERPUD2 HERPUD family member 2 2 2
MIRT703724 FAM127A retrotransposon Gag like 8C 2 2
MIRT704300 DDX19B DEAD-box helicase 19B 2 2
MIRT704335 DCTN6 dynactin subunit 6 2 2
MIRT704704 CHRFAM7A CHRNA7 (exons 5-10) and FAM7A (exons A-E) fusion 2 2
MIRT709961 TRUB2 TruB pseudouridine synthase family member 2 2 2
MIRT710169 MTRF1L mitochondrial translational release factor 1 like 2 2
MIRT710232 KCNK1 potassium two pore domain channel subfamily K member 1 2 2
MIRT711546 MSH3 mutS homolog 3 2 2
MIRT712468 KCNC3 potassium voltage-gated channel subfamily C member 3 2 2
MIRT714174 PHF7 PHD finger protein 7 2 2
MIRT714511 SHE Src homology 2 domain containing E 2 2
MIRT714702 MT1A metallothionein 1A 2 2
MIRT714775 TERF1 telomeric repeat binding factor 1 2 2
MIRT715269 RNF125 ring finger protein 125 2 2
MIRT715317 POLR2E RNA polymerase II subunit E 2 2
MIRT716450 TMPRSS11BNL TMPRSS11B N-terminal like, pseudogene 2 2
MIRT716611 MPPED1 metallophosphoesterase domain containing 1 2 2
MIRT717609 DSTYK dual serine/threonine and tyrosine protein kinase 2 2
MIRT718201 PSMF1 proteasome inhibitor subunit 1 2 2
MIRT718834 CDT1 chromatin licensing and DNA replication factor 1 2 2
MIRT719358 ITPKB inositol-trisphosphate 3-kinase B 2 2
MIRT720005 SNRPD3 small nuclear ribonucleoprotein D3 polypeptide 2 2
MIRT720017 CBX5 chromobox 5 2 2
MIRT720420 SPRED3 sprouty related EVH1 domain containing 3 2 2
MIRT720509 PHKG2 phosphorylase kinase catalytic subunit gamma 2 2 2
MIRT721235 CRCP CGRP receptor component 2 2
MIRT721268 SH3D19 SH3 domain containing 19 2 2
MIRT722528 PLXNA2 plexin A2 2 2
MIRT722913 COA4 cytochrome c oxidase assembly factor 4 homolog 2 2
MIRT724342 RNPEPL1 arginyl aminopeptidase like 1 2 2
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-939 Ginsenoside Rh2 NULL 119307 Microarray NSCLC cell line A549 23152132 2013 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-939 Dabrafenib 44462760 NSC764134 approved resistant cell line (A375)
hsa-mir-939 Cisplatin 5460033 NSC119875 approved resistant cell line (BxPC3)
hsa-mir-939 Ceritinib 57379345 NSC776422 approved resistant cell line (H3122)
hsa-miR-939-3p Gefitinib 123631 NSC715055 approved resistant cell line (PC9)
hsa-miR-939-3p Osimertinib 71496458 NSC779217 approved resistant cell line (PC9)
hsa-miR-939-3p Osimertinib 71496458 NSC779217 approved resistant cell line (HCC827)
hsa-miR-939-3p Cisplatin 5460033 NSC119875 approved resistant cell line (A2780)
hsa-miR-939-3p Gemcitabine 60750 NSC613327 approved resistant cell line (PANC-1) (1500 ng/ml)

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