miRTarBase - #MIRT456135


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pre-miRNA Information
pre-miRNA hsa-mir-7515   
Genomic Coordinates chr2: 6650373 - 6650439
Description Homo sapiens miR-7515 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-7515
Sequence 46| AGAAGGGAAGAUGGUGAC |63
Evidence Experimental
Experiments Cloned
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1451879371 1 dbSNP
rs576086800 3 dbSNP
rs753372632 5 dbSNP
rs1337497055 7 dbSNP
rs1405449301 9 dbSNP
rs1032296398 10 dbSNP
rs960195576 12 dbSNP
rs1470711310 14 dbSNP
Putative Targets

Gene Information
Gene Symbol SAMD10   
Synonyms C20orf136, dJ591C20, dJ591C20.7
Description sterile alpha motif domain containing 10
Transcript NM_080621   
Expression
Putative miRNA Targets on SAMD10
3'UTR of SAMD10
(miRNA target sites are highlighted)		 
>SAMD10|NM_080621|3'UTR
   1 CTGCTGCTGAGGCTTGAACCCAGACCCCAGCACTGTGATGGGAGTCCACGGCTAGGGAGGAGGCCAAGCTGGCCCCGCAG
  81 CGCCTCTTGGACCCTGCGGGATGCCGGGGCGGCCAGGCTGGCCCAACGGACAGACAGGACCAGGATCACACCTCCAGGCG
 161 CCTCTGGTTGGACATTCCAGGTCGTGCCCTGGGGCTGGGTGGGTAGGGGGCTGCTTGAGTGTGGCCCCACCTCCTGGGAC
 241 CTGAGCCCAAGCCCTCCCCTGGTGCAGCTGGCAGCATGTGGGGCAGCTGCCTGGAGCCAGAACCGGTTTGGATGTCCCCC
 321 CTAGACTCCCAGGGAGTCTGTTTATTTACATTCCCCTCTCCACGTGATGTCGGTCCCCCATCGCCTGCTGAGTCACTTGT
 401 CTGTCCACCCACCCAGCCCAGTTCTAGGTCGTTCCCCAGCACCTCCAGGTTGGCCCACACAGGTACCATAAGCTGCCTCG
 481 GCTCCCTGTGGCTTGTGCCCATGCACCTGCCAGGGCCCAGCAGGCCAACCCATCATCTAGAGTAGTGGCCATCAGCACCC
 561 GCCTAACGGGCACCATGCCAAGCACTTTCATCATTATTTATACATCGTCACCACACCCCCTCTATTCATGAGAAGTAAAG
 641 CTGAGAAAGGACCAGATTGACCAAGCGCCAGAGACAAAATGTGGCACAACGAGAACCCCAGCCCTGTCCAGGTGGCTCCG
 721 CGCCCAGGGCCCAGGCTTAGCAGTGCTCCCTGCCCTATCTTTGGGAAAATCTTGCTTTTATGGTCTTCCCCCCTCGCCCT
 801 CAAGAACAAGGGCCTTGTGCGTGGGCCTTCCCATTGCTGCTTTCCCAAGAAGGCCTGGATTCAGGGGAGAGGCCTTCCCA
 881 GGGCCACTCCCCTTACACCCTCCCAGAGGCCTGAGCAACCCCTCTCTGGGTGGTTTGGGGCTGGTGCTGCCTGGCGGAAG
 961 GACAGTGAGGGCGGCCCTAGCCGCCTCCACCCTCTTGCGCCTCTGCCCTCTCCCAGTCCCCCTGTGGCTTCTGAAAATCT
1041 CAGGGACAGATGAGGCTGAGCCCCTAGTCCCCTCTGTGTGCTTTGAGCCTCCAGACTCGAGGCTGGTCACTGCAGGTCCC
1121 AGGTGGAATTTGGACAACTGGCCTGGCCGCTCCCATCCTGTAAGCCCCCACCACGGGGAGACCCTCATCCCTGCCCCTGT
1201 GTGGCTGCGCAAGTATTCTGCCCGCCTCCCACCATCAGCCTTCGCCCAAGGGGCCCTTCTGCCTCTGCTTCCCTCCCTTC
1281 TCCTCTGTCTTGCCCTGGCCCACGCACGCCTGTCTCGTCTTCCTTGTTTTGCTGCACTCACTTTTTTATACTCTGACAAA
1361 AAAAAAAAATCAGAAATAAAGCTGGTTCCCAAGTGCTAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' caGUGGUAGAAGGGAAGa 5'
            ::|:  | ||||||| 
Target 5' tcTGCTTCCCTCCCTTCt 3'
 1264 - 1281 144.00 -12.40
2 
miRNA  3' cagUGGUAGAAGGGAAGa 5'
             ||| || ||||| | 
Target 5' gagACCCTCATCCCTGCc 3'
 1178 - 1195 127.00 -10.90
3 
miRNA  3' cagugguagaaGGGAAGa 5'
                     |||||| 
Target 5' cgcccaaggggCCCTTCt 3'
 1243 - 1260 120.00 -13.50
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN26993715 4 COSMIC
COSN31592342 13 COSMIC
COSN30193239 27 COSMIC
COSN30102722 28 COSMIC
COSN30450681 55 COSMIC
COSN30452648 56 COSMIC
COSN30514870 72 COSMIC
COSN13874433 81 COSMIC
COSN20063798 82 COSMIC
COSN26993717 83 COSMIC
COSN28698931 98 COSMIC
COSN31535444 110 COSMIC
COSN30143670 111 COSMIC
COSN30461607 157 COSMIC
COSN31522987 159 COSMIC
COSN30227321 167 COSMIC
COSN30496883 172 COSMIC
COSN20922027 372 COSMIC
COSN32063958 495 COSMIC
COSN15574198 778 COSMIC
COSN20116701 792 COSMIC
COSN4781580 944 COSMIC
COSN15662054 987 COSMIC
COSN22443252 1033 COSMIC
COSN15726512 1094 COSMIC
COSN31596515 1114 COSMIC
COSN31482521 1120 COSMIC
COSN20116699 1197 COSMIC
COSN24112095 1224 COSMIC
COSN27452543 1358 COSMIC
rs41278232 246 GWAS
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1303785813 3 dbSNP
rs1379538050 8 dbSNP
rs1404623257 9 dbSNP
rs769572436 11 dbSNP
rs1412803427 16 dbSNP
rs1450647798 17 dbSNP
rs747913170 20 dbSNP
rs781063658 23 dbSNP
rs1322882552 25 dbSNP
rs774633304 25 dbSNP
rs768623865 26 dbSNP
rs1354157928 28 dbSNP
rs1168524700 35 dbSNP
rs1407310929 38 dbSNP
rs1297695070 39 dbSNP
rs907542129 42 dbSNP
rs370063493 49 dbSNP
rs372297393 50 dbSNP
rs1221184366 51 dbSNP
rs1256304489 62 dbSNP
rs1458551380 64 dbSNP
rs562253504 69 dbSNP
rs542225205 72 dbSNP
rs562928151 76 dbSNP
rs1197996524 77 dbSNP
rs773342683 79 dbSNP
rs573604503 81 dbSNP
rs542640481 82 dbSNP
rs1446189259 85 dbSNP
rs957905798 93 dbSNP
rs925153490 94 dbSNP
rs904604778 95 dbSNP
rs1207050550 97 dbSNP
rs817341 98 dbSNP
rs1437439908 99 dbSNP
rs766068072 105 dbSNP
rs967756166 106 dbSNP
rs1342995350 110 dbSNP
rs1381524010 111 dbSNP
rs1020304100 118 dbSNP
rs946036451 121 dbSNP
rs1014290027 127 dbSNP
rs1437863117 128 dbSNP
rs1221432137 134 dbSNP
rs960096919 138 dbSNP
rs1034465800 149 dbSNP
rs1001699059 151 dbSNP
rs1057508722 152 dbSNP
rs763177759 159 dbSNP
rs1485839824 162 dbSNP
rs938936399 166 dbSNP
rs1319033644 172 dbSNP
rs927479823 174 dbSNP
rs899331695 183 dbSNP
rs572667308 184 dbSNP
rs1413058199 193 dbSNP
rs919686191 195 dbSNP
rs1157033936 196 dbSNP
rs1344639045 199 dbSNP
rs1453010927 206 dbSNP
rs1294085242 207 dbSNP
rs1367346974 209 dbSNP
rs532252890 210 dbSNP
rs866671614 213 dbSNP
rs1024419692 214 dbSNP
rs961353771 220 dbSNP
rs1388832218 221 dbSNP
rs912201687 222 dbSNP
rs1315853835 223 dbSNP
rs1221627329 228 dbSNP
rs1294655107 237 dbSNP
rs1490000742 241 dbSNP
rs41278232 246 dbSNP
rs1005147619 248 dbSNP
rs1028198702 251 dbSNP
rs570122194 258 dbSNP
rs1407498839 261 dbSNP
rs886080179 262 dbSNP
rs967838330 263 dbSNP
rs1166985659 264 dbSNP
rs1051358682 268 dbSNP
rs1367448823 275 dbSNP
rs1422604311 282 dbSNP
rs1370894832 286 dbSNP
rs933023068 306 dbSNP
rs1173057241 316 dbSNP
rs550262541 320 dbSNP
rs1316444895 322 dbSNP
rs1357946174 322 dbSNP
rs1245826817 323 dbSNP
rs1038762397 329 dbSNP
rs1275841396 330 dbSNP
rs1439964413 334 dbSNP
rs891801003 335 dbSNP
rs936476795 340 dbSNP
rs1232583027 350 dbSNP
rs925156292 354 dbSNP
rs1190200784 358 dbSNP
rs978391608 363 dbSNP
rs371574600 364 dbSNP
rs780189807 370 dbSNP
rs931484979 371 dbSNP
rs920071578 372 dbSNP
rs992819168 373 dbSNP
rs960064758 374 dbSNP
rs1168050838 375 dbSNP
rs182034653 376 dbSNP
rs1034392287 382 dbSNP
rs558113700 383 dbSNP
rs1036755303 384 dbSNP
rs939773889 385 dbSNP
rs1451244402 388 dbSNP
rs912238153 393 dbSNP
rs986480927 399 dbSNP
rs1280909034 402 dbSNP
rs1220306063 405 dbSNP
rs1213249315 406 dbSNP
rs1272662140 407 dbSNP
rs963851379 409 dbSNP
rs921188819 412 dbSNP
rs1296053054 414 dbSNP
rs1189278045 415 dbSNP
rs373055758 430 dbSNP
rs1366404025 431 dbSNP
rs1184572586 432 dbSNP
rs1418471653 438 dbSNP
rs527633156 438 dbSNP
rs967889317 448 dbSNP
rs1005484034 449 dbSNP
rs1403417708 454 dbSNP
rs1020769389 460 dbSNP
rs1320635754 461 dbSNP
rs1328714771 474 dbSNP
rs571867092 480 dbSNP
rs1030581011 487 dbSNP
rs1360381040 492 dbSNP
rs933236021 495 dbSNP
rs923160296 501 dbSNP
rs1428551250 502 dbSNP
rs956148113 506 dbSNP
rs367989431 507 dbSNP
rs1323079003 508 dbSNP
rs1209442103 509 dbSNP
rs1170442374 522 dbSNP
rs1448682388 525 dbSNP
rs1190890238 529 dbSNP
rs1036136737 532 dbSNP
rs900185027 532 dbSNP
rs1038733013 538 dbSNP
rs936454969 543 dbSNP
rs1426850203 544 dbSNP
rs1479868471 546 dbSNP
rs1158657199 558 dbSNP
rs140467283 560 dbSNP
rs903625621 561 dbSNP
rs1042212235 567 dbSNP
rs1350960519 569 dbSNP
rs1181496255 570 dbSNP
rs1407209777 573 dbSNP
rs1471967203 579 dbSNP
rs945235184 583 dbSNP
rs1229190274 585 dbSNP
rs1281382345 586 dbSNP
rs1348684033 589 dbSNP
rs1239447352 596 dbSNP
rs1044647354 599 dbSNP
rs1490493192 600 dbSNP
rs995686927 600 dbSNP
rs898696931 602 dbSNP
rs917835439 604 dbSNP
rs992076686 606 dbSNP
rs114206001 607 dbSNP
rs1365156734 610 dbSNP
rs771526417 615 dbSNP
rs927292464 615 dbSNP
rs1343281242 617 dbSNP
rs1386415250 620 dbSNP
rs750780344 627 dbSNP
rs932336706 634 dbSNP
rs1392301312 636 dbSNP
rs1226241953 641 dbSNP
rs189919447 653 dbSNP
rs1334191824 654 dbSNP
rs1016788133 658 dbSNP
rs983636513 663 dbSNP
rs757683106 666 dbSNP
rs1284426305 667 dbSNP
rs1360093809 669 dbSNP
rs374097543 671 dbSNP
rs1408641439 676 dbSNP
rs1030505940 690 dbSNP
rs1196143261 691 dbSNP
rs879889813 691 dbSNP
rs913778501 692 dbSNP
rs960790888 696 dbSNP
rs1243165825 702 dbSNP
rs1035783496 710 dbSNP
rs1430406417 712 dbSNP
rs1385135784 714 dbSNP
rs1238911514 717 dbSNP
rs1462869200 718 dbSNP
rs151221020 719 dbSNP
rs117649689 721 dbSNP
rs1406884776 722 dbSNP
rs1337500256 723 dbSNP
rs1385036508 728 dbSNP
rs1450512442 731 dbSNP
rs1022908997 736 dbSNP
rs1358632557 739 dbSNP
rs995738832 743 dbSNP
rs1017206792 744 dbSNP
rs1416179660 748 dbSNP
rs184986517 751 dbSNP
rs1000969561 760 dbSNP
rs1194835145 770 dbSNP
rs1263342782 787 dbSNP
rs1016211089 788 dbSNP
rs1181202397 788 dbSNP
rs903592472 791 dbSNP
rs1439965631 792 dbSNP
rs201761934 792 dbSNP
rs200172652 793 dbSNP
rs945188676 793 dbSNP
rs1468357037 794 dbSNP
rs397840894 794 dbSNP
rs11474170 796 dbSNP
rs200522482 796 dbSNP
rs1325238865 798 dbSNP
rs201868957 798 dbSNP
rs932362634 812 dbSNP
rs1056366656 820 dbSNP
rs572730081 821 dbSNP
rs1323908441 824 dbSNP
rs1046513 827 dbSNP
rs1290123048 830 dbSNP
rs780084633 831 dbSNP
rs559300304 833 dbSNP
rs1207372630 837 dbSNP
rs1260223881 838 dbSNP
rs817340 839 dbSNP
rs1348087247 840 dbSNP
rs926549837 841 dbSNP
rs1431719518 846 dbSNP
rs1479543794 849 dbSNP
rs1409918487 852 dbSNP
rs1175826263 855 dbSNP
rs764685992 863 dbSNP
rs1366741111 867 dbSNP
rs1455381849 871 dbSNP
rs988426125 873 dbSNP
rs817339 879 dbSNP
rs1350301639 881 dbSNP
rs927759332 884 dbSNP
rs1165884034 886 dbSNP
rs556358208 891 dbSNP
rs981579440 898 dbSNP
rs1221258026 900 dbSNP
rs536795993 926 dbSNP
rs1022959935 928 dbSNP
rs1240539295 929 dbSNP
rs909261248 932 dbSNP
rs1259551644 941 dbSNP
rs974036804 950 dbSNP
rs1223700732 952 dbSNP
rs962650740 955 dbSNP
rs1489930027 956 dbSNP
rs567552234 960 dbSNP
rs983950188 965 dbSNP
rs554090690 969 dbSNP
rs1408954635 972 dbSNP
rs1161383370 973 dbSNP
rs1157010950 975 dbSNP
rs1361998934 976 dbSNP
rs1015848856 982 dbSNP
rs950856933 989 dbSNP
rs78056322 998 dbSNP
rs1482931811 999 dbSNP
rs1190001107 1012 dbSNP
rs1489655024 1014 dbSNP
rs1292638395 1018 dbSNP
rs35124681 1018 dbSNP
rs976248089 1019 dbSNP
rs964920088 1020 dbSNP
rs1224967946 1021 dbSNP
rs1304156366 1022 dbSNP
rs766118264 1024 dbSNP
rs760617781 1027 dbSNP
rs1247298772 1047 dbSNP
rs571175628 1048 dbSNP
rs1294547785 1055 dbSNP
rs1357801724 1057 dbSNP
rs891306633 1062 dbSNP
rs1233733029 1063 dbSNP
rs1481703376 1066 dbSNP
rs1030228511 1067 dbSNP
rs996620465 1076 dbSNP
rs1439047541 1077 dbSNP
rs1254095464 1081 dbSNP
rs1164181238 1085 dbSNP
rs1207702089 1092 dbSNP
rs551285295 1098 dbSNP
rs1017848049 1099 dbSNP
rs35441244 1113 dbSNP
rs1163724565 1120 dbSNP
rs1269633449 1121 dbSNP
rs1443857757 1122 dbSNP
rs1295976829 1123 dbSNP
rs1043463908 1125 dbSNP
rs531381546 1127 dbSNP
rs1311127798 1130 dbSNP
rs1452698494 1144 dbSNP
rs1000532003 1148 dbSNP
rs111264234 1149 dbSNP
rs1228115758 1157 dbSNP
rs1274083236 1164 dbSNP
rs1309508791 1170 dbSNP
rs1202650065 1172 dbSNP
rs548794153 1174 dbSNP
rs1185487545 1175 dbSNP
rs1244896032 1179 dbSNP
rs1471735170 1180 dbSNP
rs1419912106 1182 dbSNP
rs1411417846 1184 dbSNP
rs1167942105 1189 dbSNP
rs1388486145 1190 dbSNP
rs1052376459 1193 dbSNP
rs1020665673 1194 dbSNP
rs71767561 1199 dbSNP
rs927843430 1208 dbSNP
rs767544456 1209 dbSNP
rs529030297 1216 dbSNP
rs948839159 1221 dbSNP
rs567952460 1222 dbSNP
rs540185037 1223 dbSNP
rs376000549 1224 dbSNP
rs1377182860 1225 dbSNP
rs1205659910 1234 dbSNP
rs908508143 1238 dbSNP
rs752742314 1243 dbSNP
rs983082247 1244 dbSNP
rs955793274 1250 dbSNP
rs1435487093 1251 dbSNP
rs1476302642 1252 dbSNP
rs1191229833 1265 dbSNP
rs1029866317 1271 dbSNP
rs1002065512 1275 dbSNP
rs1480528108 1287 dbSNP
rs1396228726 1292 dbSNP
rs1177996309 1293 dbSNP
rs868016742 1303 dbSNP
rs1038696185 1304 dbSNP
rs964170478 1305 dbSNP
rs1429148609 1307 dbSNP
rs1022073619 1308 dbSNP
rs1281575228 1314 dbSNP
rs192690245 1316 dbSNP
rs909218248 1317 dbSNP
rs545740514 1325 dbSNP
rs1284951549 1352 dbSNP
rs1205408987 1357 dbSNP
rs892160853 1359 dbSNP
rs1253805478 1365 dbSNP
rs1052514013 1367 dbSNP
rs75572855 1369 dbSNP
rs1375552828 1370 dbSNP
rs1490420683 1370 dbSNP
rs74986911 1370 dbSNP
rs576692403 1373 dbSNP
rs1158638446 1376 dbSNP
rs1410810978 1378 dbSNP
rs371305393 1381 dbSNP
rs1158450084 1389 dbSNP
rs1366622781 1390 dbSNP
rs542859155 1394 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions TZM-bl
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM1462574. RNA binding protein: AGO2. Condition:TZM-bl ami BaL ...

- Whisnant AW; Bogerd HP; Flores O; Ho P; et al., 2013, mBio.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' cagugguaGAAGGGAAGa 5'
                  | ||||||| 
Target 5' -----uucCCUCCCUUCu 3'
 		1 - 13
Article - Whisnant AW; Bogerd HP; Flores O; Ho P; et al.
- mBio, 2013
UNLABELLED: The question of how HIV-1 interfaces with cellular microRNA (miRNA) biogenesis and effector mechanisms has been highly controversial. Here, we first used deep sequencing of small RNAs present in two different infected cell lines (TZM-bl and C8166) and two types of primary human cells (CD4(+) peripheral blood mononuclear cells [PBMCs] and macrophages) to unequivocally demonstrate that HIV-1 does not encode any viral miRNAs. Perhaps surprisingly, we also observed that infection of T cells by HIV-1 has only a modest effect on the expression of cellular miRNAs at early times after infection. Comprehensive analysis of miRNA binding to the HIV-1 genome using the photoactivatable ribonucleoside-induced cross-linking and immunoprecipitation (PAR-CLIP) technique revealed several binding sites for cellular miRNAs, a subset of which were shown to be capable of mediating miRNA-mediated repression of gene expression. However, the main finding from this analysis is that HIV-1 transcripts are largely refractory to miRNA binding, most probably due to extensive viral RNA secondary structure. Together, these data demonstrate that HIV-1 neither encodes viral miRNAs nor strongly influences cellular miRNA expression, at least early after infection, and imply that HIV-1 transcripts have evolved to avoid inhibition by preexisting cellular miRNAs by adopting extensive RNA secondary structures that occlude most potential miRNA binding sites. IMPORTANCE: MicroRNAs (miRNAs) are a ubiquitous class of small regulatory RNAs that serve as posttranscriptional regulators of gene expression. Previous work has suggested that HIV-1 might subvert the function of the cellular miRNA machinery by expressing viral miRNAs or by dramatically altering the level of cellular miRNA expression. Using very sensitive approaches, we now demonstrate that neither of these ideas is in fact correct. Moreover, HIV-1 transcripts appear to largely avoid regulation by cellular miRNAs by adopting an extensive RNA secondary structure that occludes the ability of cellular miRNAs to interact with viral mRNAs. Together, these data suggest that HIV-1, rather than seeking to control miRNA function in infected cells, has instead evolved a mechanism to become largely invisible to cellular miRNA effector mechanisms.
LinkOut: [PMID: 23592263]
CLIP-seq Support 1 for dataset GSM1462574
Method / RBP PAR-CLIP / AGO2
Cell line / Condition TZM-bl / TZM-bl ami BaL
Location of target site ENST00000369886.3 | 3UTR | UUCCCUCCCUUCUCCUCUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23592263 / GSE59944
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
116 hsa-miR-7515 Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT063460 SKI SKI proto-oncogene 2 4
MIRT089615 MAT2A methionine adenosyltransferase 2A 2 10
MIRT100238 PRR3 proline rich 3 2 4
MIRT159239 NRBP1 nuclear receptor binding protein 1 2 2
MIRT183526 BTG2 BTG anti-proliferation factor 2 2 2
MIRT266866 SLC25A44 solute carrier family 25 member 44 2 2
MIRT304116 CNNM4 cyclin and CBS domain divalent metal cation transport mediator 4 2 4
MIRT331077 EIF5AL1 eukaryotic translation initiation factor 5A-like 1 2 2
MIRT350659 PDIA6 protein disulfide isomerase family A member 6 2 2
MIRT438442 MET MET proto-oncogene, receptor tyrosine kinase 3 1
MIRT443555 ZFP3 ZFP3 zinc finger protein 2 2
MIRT447969 MSH6 mutS homolog 6 2 2
MIRT448635 ONECUT1 one cut homeobox 1 2 2
MIRT451778 USP36 ubiquitin specific peptidase 36 2 2
MIRT452615 REPIN1 replication initiator 1 2 2
MIRT453433 GLG1 golgi glycoprotein 1 2 2
MIRT454015 ALKBH5 alkB homolog 5, RNA demethylase 2 2
MIRT454961 TPM2 tropomyosin 2 2 2
MIRT455364 KDM5C lysine demethylase 5C 2 2
MIRT455434 ID3 inhibitor of DNA binding 3, HLH protein 2 2
MIRT455456 EPB41L4B erythrocyte membrane protein band 4.1 like 4B 2 2
MIRT455595 TAF12 TATA-box binding protein associated factor 12 2 2
MIRT455689 GLO1 glyoxalase I 2 2
MIRT455949 CYP4A22 cytochrome P450 family 4 subfamily A member 22 2 2
MIRT456135 SAMD10 sterile alpha motif domain containing 10 2 2
MIRT456821 PIGP phosphatidylinositol glycan anchor biosynthesis class P 2 2
MIRT457441 NOL10 nucleolar protein 10 2 2
MIRT458048 TSEN54 tRNA splicing endonuclease subunit 54 2 2
MIRT458237 NXPH3 neurexophilin 3 2 2
MIRT458671 GPR35 G protein-coupled receptor 35 2 2
MIRT458741 CES2 carboxylesterase 2 2 2
MIRT459102 CYP4A11 cytochrome P450 family 4 subfamily A member 11 2 2
MIRT459676 VPS37C VPS37C, ESCRT-I subunit 2 2
MIRT459776 IDH3A isocitrate dehydrogenase 3 (NAD(+)) alpha 2 2
MIRT461975 PACSIN1 protein kinase C and casein kinase substrate in neurons 1 2 2
MIRT462267 TPI1 triosephosphate isomerase 1 2 2
MIRT463296 ZFP91 ZFP91 zinc finger protein 2 2
MIRT463446 ZC3HAV1L zinc finger CCCH-type containing, antiviral 1 like 2 2
MIRT464379 URM1 ubiquitin related modifier 1 2 2
MIRT465552 TOB2 transducer of ERBB2, 2 2 2
MIRT467359 SP2 Sp2 transcription factor 2 2
MIRT467638 SLC7A5 solute carrier family 7 member 5 2 2
MIRT467795 SLC2A14 solute carrier family 2 member 14 2 2
MIRT468466 SET SET nuclear proto-oncogene 2 4
MIRT468725 SDC4 syndecan 4 2 2
MIRT468784 SCAMP5 secretory carrier membrane protein 5 2 2
MIRT469154 RNF121 ring finger protein 121 2 2
MIRT473436 MDM4 MDM4, p53 regulator 2 2
MIRT473636 MARK2 microtubule affinity regulating kinase 2 2 2
MIRT474242 LCLAT1 lysocardiolipin acyltransferase 1 2 2
MIRT474654 KLF13 Kruppel like factor 13 2 2
MIRT475384 ICOSLG inducible T-cell costimulator ligand 2 2
MIRT475400 ICMT isoprenylcysteine carboxyl methyltransferase 2 4
MIRT476369 GIGYF1 GRB10 interacting GYF protein 1 2 2
MIRT478017 DNAJC8 DnaJ heat shock protein family (Hsp40) member C8 2 2
MIRT478459 DAB2 DAB2, clathrin adaptor protein 2 2
MIRT478791 CRTC2 CREB regulated transcription coactivator 2 2 2
MIRT478952 COX15 COX15, cytochrome c oxidase assembly homolog 2 2
MIRT480412 C19orf47 chromosome 19 open reading frame 47 2 2
MIRT481455 ARRB2 arrestin beta 2 2 2
MIRT481556 ARL10 ADP ribosylation factor like GTPase 10 2 2
MIRT481740 APH1A aph-1 homolog A, gamma-secretase subunit 2 2
MIRT483592 SLC26A9 solute carrier family 26 member 9 2 2
MIRT484423 SNX19 sorting nexin 19 2 2
MIRT484727 HOXB8 homeobox B8 2 6
MIRT487419 CACNB1 calcium voltage-gated channel auxiliary subunit beta 1 2 2
MIRT487622 C20orf96 chromosome 20 open reading frame 96 2 2
MIRT488048 PABPC1L2B poly(A) binding protein cytoplasmic 1 like 2B 2 2
MIRT488064 PABPC1L2A poly(A) binding protein cytoplasmic 1 like 2A 2 2
MIRT488587 ST7L suppression of tumorigenicity 7 like 2 2
MIRT488696 NAT9 N-acetyltransferase 9 (putative) 2 2
MIRT489175 ANKRD45 ankyrin repeat domain 45 2 4
MIRT490435 MYL9 myosin light chain 9 2 2
MIRT490452 GLUD1 glutamate dehydrogenase 1 2 2
MIRT490704 FSTL4 follistatin like 4 2 2
MIRT491038 ALPK3 alpha kinase 3 2 2
MIRT491249 HCN2 hyperpolarization activated cyclic nucleotide gated potassium and sodium channel 2 2 2
MIRT491632 SEMA4G semaphorin 4G 2 2
MIRT492491 RAPGEF1 Rap guanine nucleotide exchange factor 1 2 2
MIRT492506 RANBP10 RAN binding protein 10 2 4
MIRT493917 FAM127B retrotransposon Gag like 8A 2 4
MIRT494012 DUSP9 dual specificity phosphatase 9 2 2
MIRT499188 RBPJL recombination signal binding protein for immunoglobulin kappa J region like 2 2
MIRT499813 LONRF3 LON peptidase N-terminal domain and ring finger 3 2 2
MIRT501837 NCOA2 nuclear receptor coactivator 2 2 2
MIRT504067 KCTD12 potassium channel tetramerization domain containing 12 2 4
MIRT505313 TOR1AIP2 torsin 1A interacting protein 2 2 2
MIRT511829 H2AFX H2A histone family member X 2 4
MIRT515497 GTF2F1 general transcription factor IIF subunit 1 2 2
MIRT518629 NONO non-POU domain containing octamer binding 2 2
MIRT519774 ZNF354B zinc finger protein 354B 2 8
MIRT521806 POM121C POM121 transmembrane nucleoporin C 2 2
MIRT522621 MAP7D1 MAP7 domain containing 1 2 4
MIRT532803 CLDN11 claudin 11 2 2
MIRT533783 TMEM119 transmembrane protein 119 2 2
MIRT536433 KMT2B lysine methyltransferase 2B 2 6
MIRT538700 CASP16 caspase 16, pseudogene 2 4
MIRT544603 DCAF5 DDB1 and CUL4 associated factor 5 2 2
MIRT556730 KLHL15 kelch like family member 15 2 4
MIRT560587 LCE1B late cornified envelope 1B 2 2
MIRT560617 ANKRD36 ankyrin repeat domain 36 2 2
MIRT564348 AKR1B10 aldo-keto reductase family 1 member B10 2 2
MIRT568925 SMCR8 Smith-Magenis syndrome chromosome region, candidate 8 2 2
MIRT570946 CPE carboxypeptidase E 2 2
MIRT571235 SCAMP4 secretory carrier membrane protein 4 2 2
MIRT573805 FRMPD4 FERM and PDZ domain containing 4 2 2
MIRT574149 MARVELD1 MARVEL domain containing 1 2 2
MIRT575772 Tnfrsf10b tumor necrosis factor receptor superfamily, member 10b 2 2
MIRT576154 Hmox1 heme oxygenase 1 2 2
MIRT611312 CA8 carbonic anhydrase 8 2 4
MIRT615891 MT1A metallothionein 1A 2 2
MIRT669589 AK2 adenylate kinase 2 2 2
MIRT687186 PRKAR1A protein kinase cAMP-dependent type I regulatory subunit alpha 2 2
MIRT692711 MEAF6 MYST/Esa1 associated factor 6 2 2
MIRT701346 NR4A3 nuclear receptor subfamily 4 group A member 3 2 2
MIRT701997 MIER3 MIER family member 3 2 2
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-7 Berbamine derivative(BBMD3) NULL NULL Illumina HiSeq2000 brain 24732116 2014 down-regulated
miR-7 Curcumin NULL 969516 Microarray BxPC-3 human pancreatic carcinoma cell line 18347134 2008 down-regulated
miR-7 Enoxacin approved 3229 Quantitative real-time PCR HCT-116 and RKO colon cancer cell lines 21368194 2011 up-regulated
miR-7 5-Fluorouracil approved 3385 Microarray MCF-7 breast cancer cells 21506117 2011 down-regulated
miR-7 Aidi injection NULL NULL Microarray human breast cancer cells 21563499 2011 up-regulated
miR-7 Arsenic trioxide approved 14888 Quantitative real-time PCR acute promyelocytic leukemia 22072212 2012 up-regulated
miR-7 Marine fungal metabolite 1386A NULL NULL Microarray MCF-7 breast cancer cells. 22159329 2012 up-regulated
miR-7 Interleukin 13 (IL-13) NULL NULL Quantitative real-time PCR bronchial epithelial cells 22453679 2012 down-regulated
miR-7 1,2,6-Tri-O-galloyl-beta-D-glucopyranose NULL NULL Microarray HepG2 hepatocarcinoma cells. 22506400 2011 down-regulated
miR-7 Goserelin approved 47725 Microarray prostate 22674191 2012 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-7515 Cisplatin 5460033 NSC119875 approved sensitive cell line (A2780)
hsa-miR-7515 Cisplatin 5460033 NSC119875 approved sensitive cell line
hsa-miR-7515 Tamoxifen+Fulvestrant resistant cell line (LCC9)
hsa-miR-7515 Cisplatin 5460033 NSC119875 approved resistant cell line (CIS)

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