miRTarBase - #MIRT456494


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pre-miRNA Information
pre-miRNA hsa-mir-4433a   
Genomic Coordinates chr2: 64340759 - 64340839
Description Homo sapiens miR-4433a stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-4433a-3p
Sequence 51| ACAGGAGUGGGGGUGGGACAU |71
Evidence Experimental
Experiments Illumina
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs751480515 9 dbSNP
rs557760377 15 dbSNP
rs1479580865 20 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol SERAC1   
Synonyms -
Description serine active site containing 1
Transcript NM_032861   
Expression
Putative miRNA Targets on SERAC1
3'UTR of SERAC1
(miRNA target sites are highlighted)		 
>SERAC1|NM_032861|3'UTR
   1 CAGTTGTGCTCTTCCAGTTTTCATATGTGAATTCAGTGCAAGAAACTTGGTGTTCTGTTTCTTCTTTTAAGCTCTATGCA
  81 ATCATGCAAACATAGTGATCATAGCGTCAACATGGTCTGGAGTGTGTTGCAGACTACAGAACATTGTTCTCCCTTCAAGC
 161 GCTGTAAAGCACCAACCCGGAAGTGGCAGGCACAGAAGGAAGGGCTGGATTGGGCCCCTTTGGTGTAAAGAAGTCCCTGT
 241 GTGCTGCTTTATGGTTCGCAGTGTTGGGCTTGGTGACTGGAGCAAAGCTGCTGTGAGAGAGTGTCCTTTCCCATCTGTGA
 321 CTTTCCTGGTGCATCCAGGAGGGGCACGGCAGGTTCTGAGGTAACTCAACTTACCATAAAAATGCCATTAAGAGAGTACC
 401 TAAAATGGAGAGAAGAATGAACTAGAACATTCAAGACTCTTTTACTTCTGGGTATTGATTTGCTGTACATTTTTAAAGTT
 481 TGAGTTTTTAGCTCAGTTCTACCTTTTATCTGACACATTATTACTAGTGTTAACTTTGTTAGACTTATTGTCATGTCTGG
 561 GTCAGTTCCTTGTATCTATTTTCGTATTCCTGAGAACAAATCTTTTTCTTAGAAAAATTCTAGCTTATAATAATTCTTTT
 641 CAGACTGTAGCTGCCTATGCTTGGAATTTGTCCTAGATAAGGATAAAGTAGCTAATCCATTATTGATCACAGTATGAAGT
 721 AAAACTATTCTAAGCCATTATATGAATTAGCAATTCTTAGTATCAAGATTCTCAGATTCTCTTTGGCTAAATAAACCTTT
 801 CTTCTTCCTTGCTCATTTGCAAGTGGTATTAATTGACCTCTATAGCATGTGAGTAGTAGATAATCATGTCGATGACCTTT
 881 TTTTCTTTAGAGTAACAGCATTATTGAGATATAATTTACATACCATAAGATTCACCCTTTTAAATTATACAATTCATTTT
 961 TGTTTTGTTTTGTTTGTTTAGAGACAGGGTCTGACTCTGTTGCCCAAGCTGGAGTGCAGTGGCATGATCATAGCTCATTG
1041 TAACCTCAAACTCCTGGGCTCAAGAGATCCTTTTGCTTCAGCCTCCCAAGCAGCTAGGACTACAGGCACATGCCACCACA
1121 CTTGGGTAATTAAAAAATAAATAAATACTTTTTTGTAGAGACAGGGTCTCACTGTGTTGCCCAGGTCTCAAACTCCCGAT
1201 CTCAAGCCACCCTCCCAAAATGCTGTGATTATAGGCCAGAGCCATTGTTCCCAGGCTCAATTCATTGGTTTTTAGTATAG
1281 TTCACTGAGTTGTGCAACATCATTGCTATTTAATTTCAGGCTATTTCATCATCCCCAAAAGAACCCCATACCCATGAGCA
1361 GTCAGTTCCCACCTCTGCTTTCCCAAGCCTGCGGTAAACACTAATCTGTTTTCTGTCTCTATGGATTTGGGAATTTTATG
1441 TAAATGGAATCATACAATATGTGGCCCTCTCTGCCTTCTTCCTTCTATTAGCATGTTTTCAAGGTTCATTCATGATATAG
1521 CATGTATCAGTACTACTTCATTTCTTTTTATGGCCGAAATTACTCCATTGTATGATATGCCATGTTTCTTTATCCATTCA
1601 TCAGCTGATGGACATCTAGGTTCTGTTCATTTTTGTCTATGATAAATAATGCTACCATGATCATTTGTGTACAAATTTAT
1681 GTGTGGATAGATGTTTTTGATTCTCTTGGGTGGAATTGCTGGTCAAATGGTAAGTCTATGTTTAAATTTTGAAGATGGTG
1761 AACTTTTGTAGAATGAGATAGTCGAAGCTAAAACTGGAGTATGGCATCTGAAGGTAAATGGCTCATCAATAAACTCGATA
1841 TCAACAATTAATTGTTTCATTG
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' uacAGGGUGGGGG--UGAGGACa 5'
             |: :| ||:|  ||||||| 
Target 5' tcaTTGTAACCTCAAACTCCTGg 3'
 1035 - 1057 152.00 -18.20
2 
miRNA  3' uaCA-GGGUGGGGG--UGAGGACa 5'
            || :|:|::::|  |:||||| 
Target 5' ttGTATCTATTTTCGTATTCCTGa 3'
 570 - 593 137.00 -15.60
3 
miRNA  3' uacaggGUGGGGGUGAGGACa 5'
                | |::::|||:||| 
Target 5' tcaagaCTCTTTTACTTCTGg 3'
 431 - 451 135.00 -14.20
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
215138 16 ClinVar
COSN30500967 8 COSMIC
COSN30174290 11 COSMIC
COSN24382775 16 COSMIC
COSN26994311 32 COSMIC
COSN30178377 39 COSMIC
COSN31573355 44 COSMIC
COSN30457353 49 COSMIC
COSN30168567 55 COSMIC
COSN7696354 139 COSMIC
COSN7696353 160 COSMIC
COSN31586857 198 COSMIC
COSN14697506 211 COSMIC
COSN2150414 674 COSMIC
COSN8399428 788 COSMIC
COSN26271943 1088 COSMIC
COSN21242078 1140 COSMIC
COSN15716494 1406 COSMIC
COSN32112200 1478 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs370877945 2 dbSNP
rs1318063123 3 dbSNP
rs1312394712 4 dbSNP
rs757141911 6 dbSNP
rs977187207 11 dbSNP
rs1313690025 13 dbSNP
rs199625765 16 dbSNP
rs754950981 19 dbSNP
rs200964065 21 dbSNP
rs182817906 24 dbSNP
rs752327642 25 dbSNP
rs375333121 26 dbSNP
rs1027291513 29 dbSNP
rs1421804187 31 dbSNP
rs1293705162 34 dbSNP
rs756555539 41 dbSNP
rs1230176776 46 dbSNP
rs1188209658 47 dbSNP
rs1380049977 49 dbSNP
rs750748340 51 dbSNP
rs201854885 52 dbSNP
rs1282689915 69 dbSNP
rs980548491 74 dbSNP
rs898039954 75 dbSNP
rs535894128 76 dbSNP
rs1204494691 81 dbSNP
rs1252679566 83 dbSNP
rs775037012 87 dbSNP
rs771709906 89 dbSNP
rs1244918988 90 dbSNP
rs574735577 92 dbSNP
rs920180428 93 dbSNP
rs764905483 105 dbSNP
rs537130188 106 dbSNP
rs754579027 110 dbSNP
rs1396664644 111 dbSNP
rs1053692836 112 dbSNP
rs371513597 114 dbSNP
rs552627077 117 dbSNP
rs1322077514 130 dbSNP
rs1004623209 138 dbSNP
rs191103232 143 dbSNP
rs924499658 146 dbSNP
rs1274329289 149 dbSNP
rs977303405 151 dbSNP
rs1198150839 156 dbSNP
rs570786949 160 dbSNP
rs1341485335 161 dbSNP
rs552806526 178 dbSNP
rs911713764 179 dbSNP
rs1417395423 180 dbSNP
rs986380568 193 dbSNP
rs1235446177 200 dbSNP
rs753509812 202 dbSNP
rs539077764 209 dbSNP
rs2502606 211 dbSNP
rs1435869789 214 dbSNP
rs1463036956 215 dbSNP
rs994469398 217 dbSNP
rs1011469045 218 dbSNP
rs1390616361 223 dbSNP
rs1355252099 226 dbSNP
rs1328339987 234 dbSNP
rs1462463298 234 dbSNP
rs1386980907 238 dbSNP
rs891615561 242 dbSNP
rs1052917081 257 dbSNP
rs185841896 258 dbSNP
rs938766510 260 dbSNP
rs528989576 269 dbSNP
rs1431601760 273 dbSNP
rs773083032 280 dbSNP
rs928712732 282 dbSNP
rs1334069727 298 dbSNP
rs1167760940 300 dbSNP
rs148102913 302 dbSNP
rs371165016 302 dbSNP
rs1274991520 303 dbSNP
rs948744535 304 dbSNP
rs551146754 310 dbSNP
rs749222460 320 dbSNP
rs561899989 323 dbSNP
rs1003780730 331 dbSNP
rs1367453669 345 dbSNP
rs1475812448 346 dbSNP
rs906807556 347 dbSNP
rs1045208195 348 dbSNP
rs1457006023 349 dbSNP
rs1012849498 352 dbSNP
rs549981933 353 dbSNP
rs183504699 366 dbSNP
rs1030504992 368 dbSNP
rs1482384904 369 dbSNP
rs893853840 370 dbSNP
rs1235221021 376 dbSNP
rs1295010213 382 dbSNP
rs1212076827 383 dbSNP
rs1053807941 385 dbSNP
rs1276782169 388 dbSNP
rs964710793 392 dbSNP
rs1261132690 399 dbSNP
rs935454582 402 dbSNP
rs1021316993 422 dbSNP
rs1255063984 428 dbSNP
rs1011439559 432 dbSNP
rs1189478958 437 dbSNP
rs1410331335 441 dbSNP
rs1472577747 444 dbSNP
rs781379389 448 dbSNP
rs1374297903 452 dbSNP
rs891752973 454 dbSNP
rs754977184 455 dbSNP
rs767505135 461 dbSNP
rs190976232 462 dbSNP
rs1376326343 469 dbSNP
rs1416647965 491 dbSNP
rs1306314799 501 dbSNP
rs1041050770 516 dbSNP
rs1348579981 519 dbSNP
rs1390815743 529 dbSNP
rs1307422498 538 dbSNP
rs1307275199 546 dbSNP
rs1230794575 547 dbSNP
rs1279110632 549 dbSNP
rs1348177702 552 dbSNP
rs747068528 554 dbSNP
rs1249073319 560 dbSNP
rs1360750227 572 dbSNP
rs1173680226 580 dbSNP
rs944609069 583 dbSNP
rs546040757 584 dbSNP
rs985942710 587 dbSNP
rs572356042 596 dbSNP
rs898477076 599 dbSNP
rs1266436965 601 dbSNP
rs186257497 603 dbSNP
rs541957474 611 dbSNP
rs973146438 617 dbSNP
rs1462573990 622 dbSNP
rs1298610250 626 dbSNP
rs1471298357 627 dbSNP
rs961814621 629 dbSNP
rs1375476386 630 dbSNP
rs1251751262 631 dbSNP
rs1384812255 635 dbSNP
rs574574461 635 dbSNP
rs143325124 636 dbSNP
rs1227255204 641 dbSNP
rs181604797 649 dbSNP
rs1236118627 657 dbSNP
rs866204284 676 dbSNP
rs1272063236 679 dbSNP
rs780160328 679 dbSNP
rs986934357 683 dbSNP
rs1253548478 692 dbSNP
rs934170170 703 dbSNP
rs1193367751 704 dbSNP
rs921464474 708 dbSNP
rs970981807 711 dbSNP
rs1024311491 712 dbSNP
rs1455734480 720 dbSNP
rs1186847373 725 dbSNP
rs112136556 734 dbSNP
rs1317774589 745 dbSNP
rs1286544200 748 dbSNP
rs893961397 752 dbSNP
rs1032514364 762 dbSNP
rs1437980458 773 dbSNP
rs1293978980 776 dbSNP
rs1415386216 779 dbSNP
rs964524870 780 dbSNP
rs1442843867 796 dbSNP
rs1021705546 814 dbSNP
rs1381226953 816 dbSNP
rs1360864803 819 dbSNP
rs989775702 823 dbSNP
rs28714679 824 dbSNP
rs558995632 832 dbSNP
rs1300908093 835 dbSNP
rs1320441672 840 dbSNP
rs1213684034 845 dbSNP
rs372574636 845 dbSNP
rs550791012 845 dbSNP
rs1470052210 847 dbSNP
rs1207259129 851 dbSNP
rs1446968381 863 dbSNP
rs758557615 867 dbSNP
rs138998897 870 dbSNP
rs565579609 871 dbSNP
rs1411798998 872 dbSNP
rs1474930814 874 dbSNP
rs1164053168 877 dbSNP
rs1418531467 880 dbSNP
rs1462775066 891 dbSNP
rs1318351680 892 dbSNP
rs1344207979 912 dbSNP
rs1431099480 925 dbSNP
rs1290100029 930 dbSNP
rs1376270147 933 dbSNP
rs1160854559 935 dbSNP
rs1455195323 936 dbSNP
rs146411786 941 dbSNP
rs1337607375 944 dbSNP
rs1002638922 962 dbSNP
rs1040999324 965 dbSNP
rs907012019 966 dbSNP
rs1013411258 976 dbSNP
rs1022826971 976 dbSNP
rs1485363397 976 dbSNP
rs944038101 976 dbSNP
rs898621224 980 dbSNP
rs1486363879 983 dbSNP
rs1038340795 989 dbSNP
rs1401085618 990 dbSNP
rs1250137594 991 dbSNP
rs940014363 993 dbSNP
rs1207133848 995 dbSNP
rs535572648 996 dbSNP
rs374750755 997 dbSNP
rs887331106 1001 dbSNP
rs1357879140 1004 dbSNP
rs750788519 1011 dbSNP
rs568184463 1018 dbSNP
rs1297087731 1030 dbSNP
rs1408607118 1047 dbSNP
rs1273945797 1062 dbSNP
rs1235181776 1075 dbSNP
rs542901289 1082 dbSNP
rs549869661 1089 dbSNP
rs1050762519 1126 dbSNP
rs1347496976 1143 dbSNP
rs141330022 1148 dbSNP
rs377737704 1148 dbSNP
rs1051328209 1151 dbSNP
rs1227547627 1151 dbSNP
rs757811147 1156 dbSNP
rs934287285 1162 dbSNP
rs931956862 1166 dbSNP
rs1178746571 1167 dbSNP
rs920408206 1170 dbSNP
rs143864004 1182 dbSNP
rs1407722127 1185 dbSNP
rs940392912 1189 dbSNP
rs1336894531 1197 dbSNP
rs191414100 1198 dbSNP
rs113629694 1207 dbSNP
rs1370527103 1208 dbSNP
rs981762737 1210 dbSNP
rs186617504 1211 dbSNP
rs1340055106 1216 dbSNP
rs1195328823 1224 dbSNP
rs2502607 1230 dbSNP
rs1438370633 1231 dbSNP
rs1206319908 1239 dbSNP
rs989745926 1244 dbSNP
rs1193811319 1259 dbSNP
rs991479173 1265 dbSNP
rs958308279 1271 dbSNP
rs1166861993 1274 dbSNP
rs554048353 1284 dbSNP
rs924303764 1285 dbSNP
rs981753495 1295 dbSNP
rs999665425 1311 dbSNP
rs902566426 1320 dbSNP
rs148109692 1322 dbSNP
rs1300842989 1331 dbSNP
rs534372174 1333 dbSNP
rs889781594 1336 dbSNP
rs1449137951 1344 dbSNP
rs1049775433 1349 dbSNP
rs1226749237 1353 dbSNP
rs541797956 1358 dbSNP
rs963086946 1361 dbSNP
rs1339987019 1366 dbSNP
rs77817829 1370 dbSNP
rs879139695 1384 dbSNP
rs1271209222 1390 dbSNP
rs796557956 1392 dbSNP
rs1037517216 1393 dbSNP
rs940509217 1394 dbSNP
rs1254468225 1400 dbSNP
rs578118798 1401 dbSNP
rs982262782 1406 dbSNP
rs1191845050 1410 dbSNP
rs1373208875 1413 dbSNP
rs181178026 1414 dbSNP
rs1299593355 1421 dbSNP
rs759260241 1421 dbSNP
rs1462245606 1427 dbSNP
rs577369106 1447 dbSNP
rs900084223 1448 dbSNP
rs559098235 1451 dbSNP
rs189557495 1469 dbSNP
rs1413016190 1475 dbSNP
rs1460389956 1487 dbSNP
rs1303611250 1491 dbSNP
rs1233642188 1500 dbSNP
rs1388013339 1512 dbSNP
rs1388032812 1515 dbSNP
rs73797638 1518 dbSNP
rs1462988944 1526 dbSNP
rs1185186799 1544 dbSNP
rs1257402221 1545 dbSNP
rs1054115690 1553 dbSNP
rs113171662 1555 dbSNP
rs62437108 1556 dbSNP
rs1032556636 1570 dbSNP
rs183569858 1582 dbSNP
rs145112477 1595 dbSNP
rs981171626 1596 dbSNP
rs1412992014 1599 dbSNP
rs1201193675 1607 dbSNP
rs971683772 1614 dbSNP
rs1266840730 1615 dbSNP
rs1177816179 1620 dbSNP
rs1483357435 1621 dbSNP
rs1415390081 1625 dbSNP
rs978196157 1630 dbSNP
rs1314792860 1637 dbSNP
rs1333702134 1641 dbSNP
rs1238103138 1650 dbSNP
rs143733117 1656 dbSNP
rs1355466810 1667 dbSNP
rs1202776492 1669 dbSNP
rs1341128130 1672 dbSNP
rs537946013 1674 dbSNP
rs148876640 1677 dbSNP
rs1008710497 1680 dbSNP
rs1016803656 1692 dbSNP
rs1183047638 1703 dbSNP
rs1365725884 1705 dbSNP
rs535437835 1710 dbSNP
rs1235045342 1716 dbSNP
rs1433166814 1718 dbSNP
rs1328967247 1720 dbSNP
rs1173075975 1721 dbSNP
rs1376089354 1726 dbSNP
rs1436669996 1738 dbSNP
rs1300052356 1746 dbSNP
rs145568162 1749 dbSNP
rs1394274610 1750 dbSNP
rs1390580178 1755 dbSNP
rs1028713601 1758 dbSNP
rs995526110 1769 dbSNP
rs899043737 1778 dbSNP
rs749275789 1783 dbSNP
rs113233603 1784 dbSNP
rs1302252945 1789 dbSNP
rs886272721 1795 dbSNP
rs1046252885 1802 dbSNP
rs1347885963 1804 dbSNP
rs1211656274 1805 dbSNP
rs1030037041 1808 dbSNP
rs548045820 1817 dbSNP
rs773050551 1822 dbSNP
rs949148199 1829 dbSNP
rs1376500930 1834 dbSNP
rs1240480351 1835 dbSNP
rs141132901 1836 dbSNP
rs1055157153 1837 dbSNP
rs1395956189 1838 dbSNP
rs1377237895 1841 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions TZM-bl
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM1462574. RNA binding protein: AGO2. Condition:TZM-bl ami BaL ...

- Whisnant AW; Bogerd HP; Flores O; Ho P; et al., 2013, mBio.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' uacAGGGUGGGGG--UGAGGACa 5'
             |: :| ||:|  ||||||| 
Target 5' -caUUGUAACCUCAAACUCCUG- 3'
 		1 - 21
Article - Whisnant AW; Bogerd HP; Flores O; Ho P; et al.
- mBio, 2013
UNLABELLED: The question of how HIV-1 interfaces with cellular microRNA (miRNA) biogenesis and effector mechanisms has been highly controversial. Here, we first used deep sequencing of small RNAs present in two different infected cell lines (TZM-bl and C8166) and two types of primary human cells (CD4(+) peripheral blood mononuclear cells [PBMCs] and macrophages) to unequivocally demonstrate that HIV-1 does not encode any viral miRNAs. Perhaps surprisingly, we also observed that infection of T cells by HIV-1 has only a modest effect on the expression of cellular miRNAs at early times after infection. Comprehensive analysis of miRNA binding to the HIV-1 genome using the photoactivatable ribonucleoside-induced cross-linking and immunoprecipitation (PAR-CLIP) technique revealed several binding sites for cellular miRNAs, a subset of which were shown to be capable of mediating miRNA-mediated repression of gene expression. However, the main finding from this analysis is that HIV-1 transcripts are largely refractory to miRNA binding, most probably due to extensive viral RNA secondary structure. Together, these data demonstrate that HIV-1 neither encodes viral miRNAs nor strongly influences cellular miRNA expression, at least early after infection, and imply that HIV-1 transcripts have evolved to avoid inhibition by preexisting cellular miRNAs by adopting extensive RNA secondary structures that occlude most potential miRNA binding sites. IMPORTANCE: MicroRNAs (miRNAs) are a ubiquitous class of small regulatory RNAs that serve as posttranscriptional regulators of gene expression. Previous work has suggested that HIV-1 might subvert the function of the cellular miRNA machinery by expressing viral miRNAs or by dramatically altering the level of cellular miRNA expression. Using very sensitive approaches, we now demonstrate that neither of these ideas is in fact correct. Moreover, HIV-1 transcripts appear to largely avoid regulation by cellular miRNAs by adopting an extensive RNA secondary structure that occludes the ability of cellular miRNAs to interact with viral mRNAs. Together, these data suggest that HIV-1, rather than seeking to control miRNA function in infected cells, has instead evolved a mechanism to become largely invisible to cellular miRNA effector mechanisms.
LinkOut: [PMID: 23592263]
CLIP-seq Support 1 for dataset GSM1462574
Method / RBP PAR-CLIP / AGO2
Cell line / Condition TZM-bl / TZM-bl ami BaL
Location of target site ENST00000367102.2 | 3UTR | CAUUGUAACCUCAAACUCCUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23592263 / GSE59944
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
256 hsa-miR-4433a-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT088097 SEPT2 septin 2 2 2
MIRT143134 MGRN1 mahogunin ring finger 1 2 2
MIRT153912 NCOA3 nuclear receptor coactivator 3 2 2
MIRT154894 GNAS GNAS complex locus 2 4
MIRT200996 ZNF805 zinc finger protein 805 2 2
MIRT215729 C5ORF51 chromosome 5 open reading frame 51 2 10
MIRT235593 POFUT1 protein O-fucosyltransferase 1 2 2
MIRT263250 SGPL1 sphingosine-1-phosphate lyase 1 2 2
MIRT317951 CDC5L cell division cycle 5 like 2 4
MIRT325572 HIATL1 major facilitator superfamily domain containing 14B 2 4
MIRT354739 LSM3 LSM3 homolog, U6 small nuclear RNA and mRNA degradation associated 2 2
MIRT444552 UBE2D3 ubiquitin conjugating enzyme E2 D3 2 4
MIRT446978 SUSD5 sushi domain containing 5 2 2
MIRT451036 ZNF610 zinc finger protein 610 2 2
MIRT451596 TRPM7 transient receptor potential cation channel subfamily M member 7 2 2
MIRT452025 NLRP6 NLR family pyrin domain containing 6 2 2
MIRT452594 CA6 carbonic anhydrase 6 2 2
MIRT452768 TCEA3 transcription elongation factor A3 2 4
MIRT452959 ZNF844 zinc finger protein 844 2 2
MIRT453191 ACSF2 acyl-CoA synthetase family member 2 2 2
MIRT453382 RHD Rh blood group D antigen 2 2
MIRT453685 CEBPD CCAAT/enhancer binding protein delta 2 2
MIRT455272 DDX39B DExD-box helicase 39B 2 8
MIRT455346 BAMBI BMP and activin membrane bound inhibitor 2 2
MIRT456494 SERAC1 serine active site containing 1 2 2
MIRT456585 NID1 nidogen 1 2 2
MIRT456888 DDA1 DET1 and DDB1 associated 1 2 2
MIRT457123 APOLD1 apolipoprotein L domain containing 1 2 2
MIRT457852 ZNF324B zinc finger protein 324B 2 2
MIRT457987 APAF1 apoptotic peptidase activating factor 1 2 2
MIRT459278 APOBEC3F apolipoprotein B mRNA editing enzyme catalytic subunit 3F 2 2
MIRT459625 SLC25A33 solute carrier family 25 member 33 2 2
MIRT459715 SGK494 uncharacterized serine/threonine-protein kinase SgK494 2 2
MIRT460057 RPL22L1 ribosomal protein L22 like 1 2 2
MIRT460182 UNK unkempt family zinc finger 2 6
MIRT460288 PDE11A phosphodiesterase 11A 2 2
MIRT460841 EGF epidermal growth factor 2 4
MIRT460860 TBC1D19 TBC1 domain family member 19 2 2
MIRT461519 EMC7 ER membrane protein complex subunit 7 2 2
MIRT461729 SLC27A1 solute carrier family 27 member 1 2 4
MIRT461821 SNAP23 synaptosome associated protein 23 2 2
MIRT462066 CCDC77 coiled-coil domain containing 77 2 4
MIRT462084 MSANTD2 Myb/SANT DNA binding domain containing 2 2 2
MIRT462508 MTFMT mitochondrial methionyl-tRNA formyltransferase 2 10
MIRT464239 VCP valosin containing protein 2 2
MIRT465316 TRAF5 TNF receptor associated factor 5 2 2
MIRT466549 TBL1XR1 transducin beta like 1 X-linked receptor 1 2 2
MIRT467128 SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 2 8
MIRT468091 SHCBP1 SHC binding and spindle associated 1 2 2
MIRT469630 RAD21 RAD21 cohesin complex component 2 6
MIRT471097 PIK3C2B phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta 2 2
MIRT472704 MYBL1 MYB proto-oncogene like 1 2 2
MIRT472830 MTMR10 myotubularin related protein 10 2 2
MIRT472872 MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase 2 2
MIRT472895 MTDH metadherin 2 2
MIRT473728 MAPK1 mitogen-activated protein kinase 1 2 2
MIRT473859 MAP2K4 mitogen-activated protein kinase kinase 4 2 2
MIRT474047 LONRF1 LON peptidase N-terminal domain and ring finger 1 2 2
MIRT474297 LAMC1 laminin subunit gamma 1 2 2
MIRT474658 KLF13 Kruppel like factor 13 2 2
MIRT475234 IKZF3 IKAROS family zinc finger 3 2 2
MIRT475500 HSP90B1 heat shock protein 90 beta family member 1 2 2
MIRT475742 HERPUD1 homocysteine inducible ER protein with ubiquitin like domain 1 2 4
MIRT475793 HDGF heparin binding growth factor 2 2
MIRT477254 ERGIC2 ERGIC and golgi 2 2 2
MIRT478228 DDX52 DExD-box helicase 52 2 2
MIRT478393 DCTN5 dynactin subunit 5 2 2
MIRT478754 CS citrate synthase 2 2
MIRT478827 CRKL CRK like proto-oncogene, adaptor protein 2 4
MIRT480234 C9orf41 carnosine N-methyltransferase 1 2 2
MIRT480597 BTRC beta-transducin repeat containing E3 ubiquitin protein ligase 2 2
MIRT484121 C14orf142 GON7, KEOPS complex subunit homolog 2 2
MIRT484689 PACSIN1 protein kinase C and casein kinase substrate in neurons 1 2 2
MIRT486331 C11orf54 chromosome 11 open reading frame 54 2 4
MIRT488599 FAM3C family with sequence similarity 3 member C 2 8
MIRT488833 MRRF mitochondrial ribosome recycling factor 2 2
MIRT492523 RAB15 RAB15, member RAS oncogene family 2 4
MIRT493632 HIC2 HIC ZBTB transcriptional repressor 2 2 2
MIRT500026 ABCF2 ATP binding cassette subfamily F member 2 2 8
MIRT501075 SMAD7 SMAD family member 7 2 8
MIRT503094 BTG2 BTG anti-proliferation factor 2 2 4
MIRT503336 MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 2 2
MIRT505465 STMN1 stathmin 1 2 4
MIRT505726 SERTAD3 SERTA domain containing 3 2 4
MIRT509333 MS4A4A membrane spanning 4-domains A4A 2 2
MIRT509978 KCNMB1 potassium calcium-activated channel subfamily M regulatory beta subunit 1 2 4
MIRT513068 CHST6 carbohydrate sulfotransferase 6 2 2
MIRT513446 EMP1 epithelial membrane protein 1 2 6
MIRT513736 PSD3 pleckstrin and Sec7 domain containing 3 2 4
MIRT513996 CENPQ centromere protein Q 2 4
MIRT516538 MIXL1 Mix paired-like homeobox 2 2
MIRT517606 SAV1 salvador family WW domain containing protein 1 2 2
MIRT518064 CEP89 centrosomal protein 89 2 2
MIRT518119 RNMTL1 mitochondrial rRNA methyltransferase 3 2 2
MIRT518325 WDR92 WD repeat domain 92 2 2
MIRT519048 ABCB11 ATP binding cassette subfamily B member 11 2 2
MIRT520972 SPPL2A signal peptide peptidase like 2A 2 4
MIRT521359 RPL35A ribosomal protein L35a 2 2
MIRT523359 GTF3C6 general transcription factor IIIC subunit 6 2 2
MIRT523801 FAM63A MINDY lysine 48 deubiquitinase 1 2 2
MIRT524622 C7orf73 short transmembrane mitochondrial protein 1 2 2
MIRT525550 PHB2 prohibitin 2 2 4
MIRT529709 ZBTB49 zinc finger and BTB domain containing 49 2 2
MIRT531605 PLEKHA6 pleckstrin homology domain containing A6 2 2
MIRT532387 UMPS uridine monophosphate synthetase 2 2
MIRT534468 SCD stearoyl-CoA desaturase 2 4
MIRT537546 ETNK1 ethanolamine kinase 1 2 2
MIRT541619 C11orf31 selenoprotein H 2 2
MIRT548380 ENPP5 ectonucleotide pyrophosphatase/phosphodiesterase 5 (putative) 2 4
MIRT549523 HDDC2 HD domain containing 2 2 2
MIRT549774 SOD2 superoxide dismutase 2 2 2
MIRT550578 SLC2A5 solute carrier family 2 member 5 2 2
MIRT551498 CENPN centromere protein N 2 4
MIRT552301 ITGA3 integrin subunit alpha 3 2 2
MIRT555400 PPM1L protein phosphatase, Mg2+/Mn2+ dependent 1L 2 2
MIRT556399 LUC7L LUC7 like 2 2
MIRT557047 HOXB3 homeobox B3 2 2
MIRT558072 ERO1L endoplasmic reticulum oxidoreductase 1 alpha 1 2
MIRT559659 AHCYL2 adenosylhomocysteinase like 2 2 2
MIRT561239 ZNF354B zinc finger protein 354B 2 2
MIRT566899 LRIG2 leucine rich repeats and immunoglobulin like domains 2 2 2
MIRT568786 FAM120B family with sequence similarity 120B 2 2
MIRT574014 MRPL12 mitochondrial ribosomal protein L12 2 2
MIRT574885 Dnajc6 DnaJ heat shock protein family (Hsp40) member C6 2 2
MIRT575243 Serping1 serine (or cysteine) peptidase inhibitor, clade G, member 1 2 2
MIRT576194 Vsig2 V-set and immunoglobulin domain containing 2 2 2
MIRT576309 Acbd7 acyl-Coenzyme A binding domain containing 7 2 2
MIRT576484 Lhx4 LIM homeobox protein 4 2 3
MIRT576646 Mill2 MHC I like leukocyte 2 1 1
MIRT576708 Kras Kirsten rat sarcoma viral oncogene homolog 2 2
MIRT576855 Socs6 suppressor of cytokine signaling 6 2 2
MIRT576950 Aldoa aldolase A, fructose-bisphosphate 2 2
MIRT617133 ZNF556 zinc finger protein 556 2 4
MIRT617928 ZNF783 zinc finger family member 783 2 2
MIRT618981 MRPS16 mitochondrial ribosomal protein S16 2 2
MIRT621100 SIX3 SIX homeobox 3 2 2
MIRT624537 BROX BRO1 domain and CAAX motif containing 2 2
MIRT625663 C2orf48 chromosome 2 open reading frame 48 2 2
MIRT627059 DCTN6 dynactin subunit 6 2 2
MIRT628319 CLPB ClpB homolog, mitochondrial AAA ATPase chaperonin 2 2
MIRT630859 ENTPD5 ectonucleoside triphosphate diphosphohydrolase 5 2 2
MIRT632295 TMEM65 transmembrane protein 65 2 2
MIRT634115 ZNF207 zinc finger protein 207 2 2
MIRT634736 CYP20A1 cytochrome P450 family 20 subfamily A member 1 2 2
MIRT635655 NDST3 N-deacetylase and N-sulfotransferase 3 2 2
MIRT635772 PDCL3 phosducin like 3 2 2
MIRT635911 LILRA2 leukocyte immunoglobulin like receptor A2 2 2
MIRT636365 OGFRL1 opioid growth factor receptor like 1 2 4
MIRT637251 GLRX2 glutaredoxin 2 2 2
MIRT638705 FZD4 frizzled class receptor 4 2 2
MIRT639640 PREX2 phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 2 2 2
MIRT639676 PPEF2 protein phosphatase with EF-hand domain 2 2 4
MIRT642267 SMIM17 small integral membrane protein 17 2 2
MIRT642372 ZNF581 zinc finger protein 581 2 2
MIRT643545 SLC25A17 solute carrier family 25 member 17 2 2
MIRT647994 PDE12 phosphodiesterase 12 2 2
MIRT649094 NOM1 nucleolar protein with MIF4G domain 1 2 2
MIRT650993 ZNF770 zinc finger protein 770 2 2
MIRT651956 UBE2N ubiquitin conjugating enzyme E2 N 2 2
MIRT652977 SUN2 Sad1 and UNC84 domain containing 2 2 2
MIRT654389 RBM12B RNA binding motif protein 12B 2 2
MIRT655637 OLFML2A olfactomedin like 2A 2 2
MIRT655729 NRXN3 neurexin 3 2 2
MIRT658171 FCHSD1 FCH and double SH3 domains 1 2 2
MIRT660937 ACOX1 acyl-CoA oxidase 1 2 2
MIRT662112 CERKL ceramide kinase like 2 2
MIRT662302 MPV17L MPV17 mitochondrial inner membrane protein like 2 2
MIRT662993 TMEM59 transmembrane protein 59 2 2
MIRT663071 SFR1 SWI5 dependent homologous recombination repair protein 1 2 2
MIRT663704 ABHD17B abhydrolase domain containing 17B 2 2
MIRT663864 MUC20 mucin 20, cell surface associated 2 2
MIRT665185 HAUS5 HAUS augmin like complex subunit 5 2 4
MIRT665402 WEE1 WEE1 G2 checkpoint kinase 2 2
MIRT665688 TNPO3 transportin 3 2 2
MIRT665795 TMEM170A transmembrane protein 170A 2 2
MIRT665847 TIAL1 TIA1 cytotoxic granule associated RNA binding protein like 1 2 2
MIRT666999 PDPN podoplanin 2 2
MIRT667598 LIPC lipase C, hepatic type 2 2
MIRT668576 ELMSAN1 ELM2 and Myb/SANT domain containing 1 2 4
MIRT670960 UGGT1 UDP-glucose glycoprotein glucosyltransferase 1 2 2
MIRT671187 ZNF891 zinc finger protein 891 2 2
MIRT671739 ZNF451 zinc finger protein 451 2 2
MIRT672745 ZNF585B zinc finger protein 585B 2 4
MIRT673446 ZNF583 zinc finger protein 583 2 2
MIRT679843 GPR75 G protein-coupled receptor 75 2 2
MIRT680556 ZNF584 zinc finger protein 584 2 2
MIRT680661 C1orf210 chromosome 1 open reading frame 210 2 2
MIRT681285 RFC2 replication factor C subunit 2 2 2
MIRT683264 ZNF329 zinc finger protein 329 2 2
MIRT684519 C1orf174 chromosome 1 open reading frame 174 2 2
MIRT685065 GEMIN4 gem nuclear organelle associated protein 4 2 2
MIRT685157 DTWD2 DTW domain containing 2 2 2
MIRT685168 ERCC1 ERCC excision repair 1, endonuclease non-catalytic subunit 2 2
MIRT685470 CACNG8 calcium voltage-gated channel auxiliary subunit gamma 8 2 2
MIRT686001 NEK4 NIMA related kinase 4 2 2
MIRT687027 RNF24 ring finger protein 24 2 2
MIRT687543 MOB1B MOB kinase activator 1B 2 2
MIRT687592 MANEAL mannosidase endo-alpha like 2 2
MIRT687753 KIAA1328 KIAA1328 2 2
MIRT688050 GLUL glutamate-ammonia ligase 2 2
MIRT688374 ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1 2 2
MIRT688802 CBFA2T3 CBFA2/RUNX1 translocation partner 3 2 2
MIRT688957 ATXN3 ataxin 3 2 2
MIRT689281 C5AR2 complement component 5a receptor 2 2 2
MIRT689988 NNMT nicotinamide N-methyltransferase 2 2
MIRT689997 MMP17 matrix metallopeptidase 17 2 2
MIRT690014 LUZP2 leucine zipper protein 2 2 2
MIRT690161 ELP3 elongator acetyltransferase complex subunit 3 2 2
MIRT690379 ZSWIM7 zinc finger SWIM-type containing 7 2 2
MIRT690563 MICA MHC class I polypeptide-related sequence A 2 2
MIRT691891 EVC EvC ciliary complex subunit 1 2 2
MIRT693107 SCNM1 sodium channel modifier 1 2 2
MIRT693832 ZFP64 ZFP64 zinc finger protein 2 2
MIRT694105 ZNF446 zinc finger protein 446 2 2
MIRT694179 ZNF486 zinc finger protein 486 2 2
MIRT694475 LRTOMT leucine rich transmembrane and O-methyltransferase domain containing 2 2
MIRT694998 GGA2 golgi associated, gamma adaptin ear containing, ARF binding protein 2 2 2
MIRT695031 ALG10B ALG10B, alpha-1,2-glucosyltransferase 2 2
MIRT695163 TCTN2 tectonic family member 2 2 2
MIRT695525 SLC25A34 solute carrier family 25 member 34 2 2
MIRT696067 ZNF264 zinc finger protein 264 2 2
MIRT696616 CRIPT CXXC repeat containing interactor of PDZ3 domain 2 2
MIRT696661 AGXT2 alanine--glyoxylate aminotransferase 2 2 2
MIRT696705 PNPO pyridoxamine 5'-phosphate oxidase 2 2
MIRT697173 INMT indolethylamine N-methyltransferase 2 2
MIRT697303 ZNF652 zinc finger protein 652 2 2
MIRT697491 ZBTB8B zinc finger and BTB domain containing 8B 2 2
MIRT698657 TERF2 telomeric repeat binding factor 2 2 2
MIRT699042 SOAT1 sterol O-acyltransferase 1 2 2
MIRT699185 SLX4IP SLX4 interacting protein 2 2
MIRT699598 SHOC2 SHOC2, leucine rich repeat scaffold protein 2 2
MIRT700150 RNF115 ring finger protein 115 2 2
MIRT700720 PNO1 partner of NOB1 homolog 2 2
MIRT700870 PER2 period circadian clock 2 2 2
MIRT700912 PDXK pyridoxal kinase 2 2
MIRT701095 PAPOLG poly(A) polymerase gamma 2 2
MIRT701194 OTUD3 OTU deubiquitinase 3 2 2
MIRT702203 LPP LIM domain containing preferred translocation partner in lipoma 2 2
MIRT702272 LHX4 LIM homeobox 4 2 3
MIRT703125 GPRC5A G protein-coupled receptor class C group 5 member A 2 2
MIRT703252 GNS glucosamine (N-acetyl)-6-sulfatase 2 2
MIRT703262 GNL3L G protein nucleolar 3 like 2 2
MIRT703440 FYTTD1 forty-two-three domain containing 1 2 2
MIRT704321 DCUN1D5 defective in cullin neddylation 1 domain containing 5 2 2
MIRT704393 CTSS cathepsin S 2 2
MIRT704483 CPT1A carnitine palmitoyltransferase 1A 2 2
MIRT704880 CCSER2 coiled-coil serine rich protein 2 2 2
MIRT704926 CCDC36 coiled-coil domain containing 36 2 2
MIRT705175 BZW1 basic leucine zipper and W2 domains 1 2 2
MIRT706561 EIF2AK2 eukaryotic translation initiation factor 2 alpha kinase 2 2 2
MIRT707048 TRPV2 transient receptor potential cation channel subfamily V member 2 2 2
MIRT711497 PGD phosphogluconate dehydrogenase 2 2
MIRT716644 EPGN epithelial mitogen 2 2
MIRT720083 TNRC6B trinucleotide repeat containing 6B 2 2
MIRT722288 PMPCA peptidase, mitochondrial processing alpha subunit 2 2
MIRT725468 GRAP2 GRB2-related adaptor protein 2 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-4433a Dabrafenib 44462760 NSC764134 approved resistant cell line (A375)
hsa-mir-4433a Paclitaxel 36314 NSC125973 approved resistant cell line (W1)
hsa-mir-4433a Vincristine 5978 approved resistant cell line (W1)
hsa-mir-4433a Cisplatin 5460033 NSC119875 approved resistant cell line (BxPC3)
hsa-miR-4433a-3p Platinum 23939 sensitive High Ovarian Cancer tissue
hsa-miR-4433a-3p Imatinib 5291 NSC743414 approved sensitive High Gastrointestinal Stromal Tumor cell line (882R-NC, 882R-OE, 882R-KD)
hsa-miR-4433a-3p Cisplatin 5460033 NSC119875 approved resistant High Pancreatic Cancer cell line (BxPC-3)
hsa-miR-4433a-3p Paclitaxel 36314 NSC125973 approved resistant High Non-Small Cell Lung Cancer cell line (A549)
hsa-miR-4433a-3p Imatinib 5291 NSC743414 approved sensitive High Chronic Myelogenous Leukemia tissue
hsa-miR-4433a-3p Cisplatin 5460033 NSC119875 approved resistant High Ovarian Cancer cell line (A2780CIS)
hsa-miR-4433a-3p Cisplatin 5460033 NSC119875 approved sensitive cell line (CAL-27) (mitochondrial RNA)
hsa-miR-4433a-3p Paclitaxel 36314 NSC125973 approved resistant cell line (BAS)
hsa-miR-4433a-3p Cisplatin 5460033 NSC119875 approved resistant cell line (CP20)
hsa-miR-4433a-3p Cisplatin 5460033 NSC119875 approved resistant cell line (CIS)
hsa-miR-4433a-3p Neoadjuvant chemotherapy sensitive tissue (breast cancer)
hsa-miR-4433a-3p Gemcitabine 60750 NSC613327 approved sensitive cell line (PANC-1) (1500 ng/ml)
hsa-miR-4433a-3p Gemcitabine 60750 NSC613327 approved sensitive cell line (PANC-1) (100 ng/ml)

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