miRTarBase - #MIRT457039


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pre-miRNA Information
pre-miRNA hsa-mir-3622a   
Genomic Coordinates chr8: 27701677 - 27701759
Description Homo sapiens miR-3622a stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-3622a-5p
Sequence 14| CAGGCACGGGAGCUCAGGUGAG |35
Evidence Experimental
Experiments Illumina
Editing Events in miRNAs
Modification Type Position on miR Chromosome DNA Strand Genomic Position (hg38) List of PMIDs Variant details
A-to-I 2 8 + 27701691 29233923 MiREDiBase
A-to-I 6 8 + 27701695 29233923 MiREDiBase
A-to-I 16 8 + 27701705 28550310, 29233923 MiREDiBase
A-to-I 21 8 + 27701710 29233923 MiREDiBase
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs551845360 1 dbSNP
rs946438979 3 dbSNP
rs1044808718 7 dbSNP
rs66683138 8 dbSNP
rs1157333896 10 dbSNP
rs1439657384 12 dbSNP
rs530939348 17 dbSNP
rs1232922758 20 dbSNP
rs1448152954 22 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol S1PR3   
Synonyms EDG-3, EDG3, LPB3, S1P3
Description sphingosine-1-phosphate receptor 3
Transcript NM_005226   
Expression
Putative miRNA Targets on S1PR3
3'UTR of S1PR3
(miRNA target sites are highlighted)		 
>S1PR3|NM_005226|3'UTR
   1 TCGTCTCCATGCGCCCTGCTCTGCGGCTGTGTTCTTATTTATTGCATGCGTCGCTTCCACAGGGGCCCCTCAAGAGCTGT
  81 GACTCGGGAGAGCTACCTTACTTTGACCAACAGCCTGCCCAGTGTGGATGTCTCTTACAGAGGGGGCCCAAGGAATCACC
 161 ACCCCGCTTCAGTGTAAACAACGTGCCTTGTCCACTTTGGGCTCCAGAGTCTTTCAGATGTACTAAGCTGCTGACATCAT
 241 CCACTGCCTTCTGCTGCATCCTAGACACCCTCCCTGTTGTTCACAGAGAGGGAAGGTCGTGGGCCACACAATGCTGTGTG
 321 ACCCTCTCCGTGTGCCTCTGAATGGTGTTTTGATGATTTTACACTACATTTCCTGTGCGTAGAATGGATGCTTGTATATT
 401 CGTACATCTCTATGTTACACAGAATTTGTGTTGCAGGTGTTTGCCATGTGGTACCTACATAGAATCTCCATACAACACAC
 481 AGGTAACAGGTTATACAAGTGGATTCAGACTGAACCCCCAGTACAAGGACATTGTTTTGAACTAGGTGGACATGCCATCC
 561 CTGGTCTCCTTAGACTGACATGATTCTCATGTTAACCAAGTTTTAAAAGTTCAAATTCCCCAAAAAGGCTTGTCCAAGGC
 641 TGGCCCCAGATGTGTGGGTCTGACCCACACCAGCCCTGTGTCCTGTCCTTTCAGTCATTTGTCCCTGCGTAATTTTAATC
 721 GTATTCCAAAGCCCAATTATGTGATGGTTTTCAGGTTTCTGCAAATTACAGAAGAGCCAGCCAAGATCACCCAGGAGCTT
 801 GTGCCCCCAGATGGGCCAAAGAAAGAGCCTATGAAGGAGAAGCAGAAGCAGACGGCTGGCCTGGCTCACCTTCCCACGCC
 881 AGTGGGGCAGGGGTCTGCTTCAGGAAATGGAAGCTGTCCAGGAAATGAGCAGAGATTCACAAGACAGCACTTTGATTCTA
 961 TGTTGAGTTTGTTTCTATATTAGAAAAGCAGCAAGTCAGTAATCCCCCGTGGCATCACAGCTAAGTAGCTGTGGCCACCG
1041 GCAGTTTCACAGCATCCTGAAAGCTGGCACTGATCGTGACTATCAGTGAAAGAAGTTTAATTTTCAGGTTAGAAAATGTG
1121 ATCTGGCAGTTTATGCATTCTTCAGAGTAATGTAATAATACCTATGTGATGCTGTAATTTTACTTTTCAACATAAGTTGA
1201 ACCCGTAGCAGTCTGTTTACCTTGTAAAGGGATTACTTAGAAGACATTTTTGTACATGCTCTTCCCCAAGGATTGTACGT
1281 ATTATACAAATAGATGGAAAGAAAAGTGAACACGTTTGTAGAACTTTCATAAGCACACAGTTGCTGTGTTGAGTTCTCTT
1361 TAAAAACAAGGACAAAACCAACCAGCGTTCAAAGGAACCTCCCATCAGAGTCCCCTAAAGTATTTTAGGTTCAGTGAGCA
1441 TTTGCCTGAATAAAACCTAAAAGAGTAGTCTTAACACATTACTAACTTTTTCTAAGAGAAATTGATTCCTGTTTTGTCAT
1521 CTGATGCAATTTGCTCTTATAAAGAGACATTTTCATAGGTTCAGAGTAACTCACCTCCATGGGCTGACCAAAGGCTTTTC
1601 TAATTTTTGTTACTGATGAGATGAAACCTATTTGTAAGGAGATCTTCCCCAGGAGCATTTCTGTTGCCTTCTTGACATCA
1681 ATGAAAAGTAGCATATTCTCTTATGAAATAGCATGAGAAAACACAGGGCATTTCTAGGACAGTAAAACGTTAAAGTACTG
1761 GATTAAGAAAACAACAACAGGCTGGGCGCAGTGGCTCACACCTGTAATCCCAGCACTTTGGGAGGCTGAGGCGGGTGGAT
1841 CACCTGAGGTCAGGAGTTTGTGACCAGCCTGGCCAACATAGTGAAATCCTGTTTCTACTAAAAATACAAAAATTAGCTGG
1921 ATGCGATAGCACGTGCCTGTAGTCCCAGCTACTCGGGAGGCTGAGGCTGGAGAGTTGCTCAAACCCGGGAGGCGGAGATT
2001 GCAGTGAGCCAAGATCGCACCGCTGCACTCCAGCCTGGGTGACAGAGCGACCCTCTGTCTCAAAAAATAATAATAATAAT
2081 AAATAAAACAACAACAAAATGCATCAGAGAGCCAAAACATTCAGTATTGCATTTTCACATAGGTGATGAAATGACTTTGG
2161 AACTTTATCTGTGTTATAGTTATGAGTTGCTTTGGGAGACTTGGAGCTCTCTGTAGCTATTGTTCATAACACTTTGCTCC
2241 ATAACCCTGATGTCCGCAGTATCTAAGTATCTCAGCCTTCATCCATTAACTCTACTAGGGAGCCCACAGCCACCATTTCC
2321 ACTAGGAGGTATCAATATTTGTGGTATGACATAAGGCTCCCTTGAAATAACAAGACTTTTGAGCAATCTGAATTAAAAAT
2401 ACATCAAAAAAGTAATAGCGCTCATTTGCTAAATGCAAAAAATAATCACCTTTGATACCAATGTGCACCAATATGCCTAA
2481 CTAGCTAGCCAGCTGGAGATAATTTACCAGGGAATGTTTCAAAGCCCTAACCTTGAAGTTTGGAAACAGGTGGTCTTCTA
2561 TGCTGCAGAGAAACTATGCATTAGGTCTCTTTTCAATTAGAAACCTTTACTATTTCCAATGTATGTTTGTTAAAAATAAT
2641 AATAATAAAACCAAAAGCCTTTGTGGAAACCCACTCTTCGTAGTCCATGTGATGGGATTGTTTTATCGTTTTCACCGGGT
2721 GCCCTCCCCACTGCAGGGGTGCGCACTGTTGTTGCAGGCTTGCTACCCACCTGTGTTTCTTAGCATTTCAGGAATTAAAC
2801 CACATTCAGAACCCCAAAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' gaGUGGACUCGAG---G--GCACGGAc 5'
            |:|:| ||: :   |  ||||||| 
Target 5' ccCGCTTCAGTGTAAACAACGTGCCTt 3'
 163 - 189 146.00 -15.80
2 
miRNA  3' gaguggACUCGA--GGGCACGGAc 5'
                || | |  | ||||||| 
Target 5' gctggaTGCGATAGCACGTGCCTg 3'
 1916 - 1939 146.00 -19.00
3 
miRNA  3' gaguGGACUCGAGG-GCACGGAc 5'
              |||   |||| :|||||| 
Target 5' tgacCCT---CTCCGTGTGCCTc 3'
 319 - 338 139.00 -17.60
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30131499 3 COSMIC
COSN14402280 13 COSMIC
COSN26993685 14 COSMIC
COSN29739681 22 COSMIC
COSN30516966 26 COSMIC
COSN30470393 37 COSMIC
COSN14402282 50 COSMIC
COSN26993683 53 COSMIC
COSN30175075 54 COSMIC
COSN26993684 56 COSMIC
COSN28797283 71 COSMIC
COSN26481681 98 COSMIC
COSN30528025 132 COSMIC
COSN15626195 133 COSMIC
COSN30137463 135 COSMIC
COSN30119631 217 COSMIC
COSN7577015 287 COSMIC
COSN26565494 297 COSMIC
COSN9318877 326 COSMIC
COSN32057838 331 COSMIC
COSN30123895 373 COSMIC
COSN29468733 376 COSMIC
COSN31487571 383 COSMIC
COSN30141005 408 COSMIC
COSN30534496 422 COSMIC
COSN30527691 519 COSMIC
COSN31522703 612 COSMIC
COSN15626196 620 COSMIC
COSN23801211 621 COSMIC
COSN6398646 669 COSMIC
COSN31549985 689 COSMIC
COSN30528782 707 COSMIC
COSN31568786 750 COSMIC
COSN30130605 829 COSMIC
COSN20091979 928 COSMIC
COSN31520178 928 COSMIC
COSN20091980 955 COSMIC
COSN30173198 989 COSMIC
COSN15626197 1005 COSMIC
COSN30538066 1010 COSMIC
COSN30538168 1017 COSMIC
COSN31538149 1076 COSMIC
COSN30173484 1089 COSMIC
COSN20091981 1120 COSMIC
COSN31531353 1134 COSMIC
COSN30132547 1207 COSMIC
COSN30122242 1260 COSMIC
COSN31596219 1271 COSMIC
COSN31530386 1357 COSMIC
COSN32063160 1403 COSMIC
COSN29901308 1430 COSMIC
COSN7577016 1499 COSMIC
COSN30533860 1572 COSMIC
COSN31537537 1662 COSMIC
COSN31570329 1672 COSMIC
COSN30138466 1750 COSMIC
COSN30139324 1866 COSMIC
COSN6398647 1926 COSMIC
COSN24303141 2010 COSMIC
COSN27994294 2049 COSMIC
COSN30111596 2256 COSMIC
COSN2332743 2272 COSMIC
COSN30534174 2331 COSMIC
COSN31566698 2402 COSMIC
COSN30127607 2405 COSMIC
COSN31556820 2412 COSMIC
COSN31553533 2476 COSMIC
COSN31537212 2615 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs974092105 2 dbSNP
rs778549047 3 dbSNP
rs185427056 4 dbSNP
rs1393238764 6 dbSNP
rs932199118 8 dbSNP
rs369307139 10 dbSNP
rs1465483553 11 dbSNP
rs372699188 13 dbSNP
rs768278566 14 dbSNP
rs776323960 15 dbSNP
rs1327125803 16 dbSNP
rs748645894 19 dbSNP
rs936068121 20 dbSNP
rs1305710624 22 dbSNP
rs376209295 25 dbSNP
rs773412950 26 dbSNP
rs763375924 29 dbSNP
rs374689242 30 dbSNP
rs374563468 31 dbSNP
rs1341947220 32 dbSNP
rs1173076732 34 dbSNP
rs1194388403 36 dbSNP
rs766450076 37 dbSNP
rs377016598 40 dbSNP
rs1430740066 41 dbSNP
rs1054066374 45 dbSNP
rs1052470885 49 dbSNP
rs747738750 50 dbSNP
rs745734911 51 dbSNP
rs369803061 53 dbSNP
rs1403933668 54 dbSNP
rs1250909173 58 dbSNP
rs1205634866 67 dbSNP
rs113563880 73 dbSNP
rs1010729050 86 dbSNP
rs541214032 87 dbSNP
rs1302067647 88 dbSNP
rs905127314 91 dbSNP
rs1337337163 97 dbSNP
rs1307912161 101 dbSNP
rs1216184546 102 dbSNP
rs1399049373 111 dbSNP
rs1273430372 116 dbSNP
rs997821031 119 dbSNP
rs1378060403 121 dbSNP
rs539846642 122 dbSNP
rs73496050 123 dbSNP
rs1034694186 126 dbSNP
rs1266992311 133 dbSNP
rs1182309346 143 dbSNP
rs950989053 148 dbSNP
rs772918682 150 dbSNP
rs1490866882 157 dbSNP
rs1199642704 160 dbSNP
rs1199022785 162 dbSNP
rs1483125299 163 dbSNP
rs570396361 165 dbSNP
rs371181553 166 dbSNP
rs535648295 167 dbSNP
rs1287755752 180 dbSNP
rs1016679783 182 dbSNP
rs530110742 183 dbSNP
rs1391179309 184 dbSNP
rs1395726885 190 dbSNP
rs868477762 194 dbSNP
rs1402620196 198 dbSNP
rs549884321 203 dbSNP
rs773953720 215 dbSNP
rs1161310373 216 dbSNP
rs1367030398 223 dbSNP
rs1455541240 228 dbSNP
rs1386888897 241 dbSNP
rs1317020246 248 dbSNP
rs1387846036 249 dbSNP
rs1159182892 259 dbSNP
rs1470881357 261 dbSNP
rs117135373 269 dbSNP
rs1186382918 275 dbSNP
rs572034232 299 dbSNP
rs762152917 300 dbSNP
rs1432825354 304 dbSNP
rs987642423 305 dbSNP
rs1209978409 306 dbSNP
rs1352922112 330 dbSNP
rs41287349 331 dbSNP
rs1244297422 332 dbSNP
rs935328451 339 dbSNP
rs957484772 343 dbSNP
rs1052503090 355 dbSNP
rs1243433800 357 dbSNP
rs1432649333 359 dbSNP
rs1476859693 363 dbSNP
rs1364286862 368 dbSNP
rs990216805 369 dbSNP
rs915059525 378 dbSNP
rs557433243 379 dbSNP
rs577189627 380 dbSNP
rs149513610 385 dbSNP
rs563227439 390 dbSNP
rs1448044901 392 dbSNP
rs573907766 393 dbSNP
rs188230077 402 dbSNP
rs1194493632 410 dbSNP
rs180739197 413 dbSNP
rs1209342231 414 dbSNP
rs1357249382 415 dbSNP
rs1445294659 419 dbSNP
rs552140472 421 dbSNP
rs112415204 423 dbSNP
rs564594870 425 dbSNP
rs1298124742 427 dbSNP
rs1432769313 432 dbSNP
rs113971313 438 dbSNP
rs550226125 447 dbSNP
rs1386854194 453 dbSNP
rs570358326 459 dbSNP
rs886742391 460 dbSNP
rs1182100975 461 dbSNP
rs1166320766 468 dbSNP
rs536183173 471 dbSNP
rs1389910883 477 dbSNP
rs1038100125 482 dbSNP
rs894649786 484 dbSNP
rs1476647590 494 dbSNP
rs1245499642 500 dbSNP
rs1198169645 512 dbSNP
rs1013115349 515 dbSNP
rs962503335 517 dbSNP
rs1271210494 519 dbSNP
rs1024873946 523 dbSNP
rs1482873638 526 dbSNP
rs1273392941 528 dbSNP
rs996964779 532 dbSNP
rs759550808 533 dbSNP
rs971660044 535 dbSNP
rs1029164549 549 dbSNP
rs549418921 561 dbSNP
rs758784109 565 dbSNP
rs1305689312 567 dbSNP
rs1450229930 569 dbSNP
rs1402321893 570 dbSNP
rs112665509 576 dbSNP
rs1329897604 579 dbSNP
rs1412004104 584 dbSNP
rs957326572 587 dbSNP
rs1245814466 590 dbSNP
rs1172490533 610 dbSNP
rs1481077846 620 dbSNP
rs41287351 621 dbSNP
rs1180143340 627 dbSNP
rs1348669107 634 dbSNP
rs557396285 637 dbSNP
rs910607141 649 dbSNP
rs1472357228 650 dbSNP
rs1233676022 657 dbSNP
rs965142575 674 dbSNP
rs956731534 688 dbSNP
rs752551467 693 dbSNP
rs1440472868 697 dbSNP
rs1277721186 699 dbSNP
rs988122658 702 dbSNP
rs1325627051 703 dbSNP
rs1285854273 709 dbSNP
rs577354695 710 dbSNP
rs747157839 721 dbSNP
rs534645893 722 dbSNP
rs1280923256 723 dbSNP
rs1245374127 729 dbSNP
rs1333967994 732 dbSNP
rs1357761731 732 dbSNP
rs1424695725 737 dbSNP
rs556587038 742 dbSNP
rs745955722 765 dbSNP
rs1045517860 770 dbSNP
rs1046976978 772 dbSNP
rs573843988 779 dbSNP
rs1456778097 783 dbSNP
rs926516885 784 dbSNP
rs769803019 789 dbSNP
rs1056417946 791 dbSNP
rs1179151129 805 dbSNP
rs1471957577 808 dbSNP
rs887042774 809 dbSNP
rs1038432838 813 dbSNP
rs1004101673 815 dbSNP
rs1038047356 816 dbSNP
rs898114241 824 dbSNP
rs996646436 825 dbSNP
rs1208104821 830 dbSNP
rs1013075930 833 dbSNP
rs529176041 833 dbSNP
rs1032086655 837 dbSNP
rs1468151414 838 dbSNP
rs1338559411 846 dbSNP
rs7853537 851 dbSNP
rs1314735836 852 dbSNP
rs1009004581 854 dbSNP
rs7865415 855 dbSNP
rs1319122596 858 dbSNP
rs1031860146 869 dbSNP
rs1345834514 878 dbSNP
rs893138746 879 dbSNP
rs1403770529 889 dbSNP
rs1413364862 894 dbSNP
rs1163912406 900 dbSNP
rs1328458125 905 dbSNP
rs572541146 928 dbSNP
rs1230383886 933 dbSNP
rs1187825536 940 dbSNP
rs1486176811 946 dbSNP
rs1289053689 947 dbSNP
rs1218765461 949 dbSNP
rs1320677772 954 dbSNP
rs535243041 955 dbSNP
rs761659115 957 dbSNP
rs1022298548 960 dbSNP
rs1222231226 961 dbSNP
rs756213678 962 dbSNP
rs968451462 971 dbSNP
rs148240383 978 dbSNP
rs1363300840 990 dbSNP
rs1483798144 995 dbSNP
rs926681123 997 dbSNP
rs1248025080 998 dbSNP
rs1439186707 999 dbSNP
rs939393569 1010 dbSNP
rs1434410198 1014 dbSNP
rs767197283 1028 dbSNP
rs1303969742 1029 dbSNP
rs1426844539 1038 dbSNP
rs982710954 1040 dbSNP
rs908338894 1041 dbSNP
rs1428999245 1042 dbSNP
rs1421581421 1043 dbSNP
rs370499769 1044 dbSNP
rs1188878110 1052 dbSNP
rs1487868271 1055 dbSNP
rs1269042758 1057 dbSNP
rs1224218984 1064 dbSNP
rs12342111 1074 dbSNP
rs543826928 1076 dbSNP
rs376123399 1077 dbSNP
rs915553333 1080 dbSNP
rs41287353 1082 dbSNP
rs932297207 1091 dbSNP
rs1298372402 1112 dbSNP
rs555154887 1120 dbSNP
rs570308672 1127 dbSNP
rs1344941827 1130 dbSNP
rs890896200 1135 dbSNP
rs1007906766 1138 dbSNP
rs1406950514 1142 dbSNP
rs1368969278 1148 dbSNP
rs566257190 1152 dbSNP
rs1019078440 1153 dbSNP
rs1297333358 1156 dbSNP
rs934801094 1174 dbSNP
rs1356125824 1175 dbSNP
rs1173849543 1184 dbSNP
rs892596560 1194 dbSNP
rs1411913907 1198 dbSNP
rs528668301 1206 dbSNP
rs367912406 1233 dbSNP
rs1345005297 1247 dbSNP
rs1196086194 1251 dbSNP
rs968098891 1272 dbSNP
rs41287355 1273 dbSNP
rs753212479 1279 dbSNP
rs1208599516 1280 dbSNP
rs755518882 1292 dbSNP
rs1017613951 1295 dbSNP
rs1134639 1302 dbSNP
rs1225442231 1306 dbSNP
rs960789553 1314 dbSNP
rs571008554 1315 dbSNP
rs1306551535 1329 dbSNP
rs992202903 1340 dbSNP
rs1392239551 1347 dbSNP
rs1134640 1353 dbSNP
rs1249957844 1355 dbSNP
rs1344682599 1359 dbSNP
rs1205434537 1365 dbSNP
rs1469187640 1365 dbSNP
rs191003234 1371 dbSNP
rs1177888984 1379 dbSNP
rs556647592 1388 dbSNP
rs1030394868 1402 dbSNP
rs1182057458 1407 dbSNP
rs1192406102 1408 dbSNP
rs1253049929 1414 dbSNP
rs567208999 1415 dbSNP
rs919822099 1417 dbSNP
rs950766910 1420 dbSNP
rs1461212883 1423 dbSNP
rs779344471 1430 dbSNP
rs1134641 1443 dbSNP
rs1206192122 1445 dbSNP
rs117145268 1447 dbSNP
rs758805983 1452 dbSNP
rs1134642 1454 dbSNP
rs974361363 1482 dbSNP
rs943792947 1485 dbSNP
rs182025303 1492 dbSNP
rs892670820 1499 dbSNP
rs1383342681 1510 dbSNP
rs1451658254 1510 dbSNP
rs1010130878 1519 dbSNP
rs1043876422 1522 dbSNP
rs904115873 1528 dbSNP
rs1338609772 1537 dbSNP
rs1169494138 1541 dbSNP
rs573091899 1556 dbSNP
rs1158673424 1575 dbSNP
rs1454976205 1578 dbSNP
rs1365169849 1598 dbSNP
rs928415476 1604 dbSNP
rs1422868380 1608 dbSNP
rs1161984397 1625 dbSNP
rs545218631 1631 dbSNP
rs1444390318 1634 dbSNP
rs934392711 1635 dbSNP
rs1053255062 1646 dbSNP
rs147663994 1647 dbSNP
rs752733593 1647 dbSNP
rs1261072616 1651 dbSNP
rs1205808846 1667 dbSNP
rs1353037877 1673 dbSNP
rs1263901458 1678 dbSNP
rs1368986161 1679 dbSNP
rs1002425829 1680 dbSNP
rs751959415 1682 dbSNP
rs1359858875 1683 dbSNP
rs1316951213 1684 dbSNP
rs947667204 1685 dbSNP
rs1325807213 1694 dbSNP
rs1318339092 1701 dbSNP
rs757628222 1704 dbSNP
rs1039670856 1705 dbSNP
rs1013709390 1710 dbSNP
rs900516204 1719 dbSNP
rs997548347 1721 dbSNP
rs1165890160 1743 dbSNP
rs1474681270 1749 dbSNP
rs1015672881 1750 dbSNP
rs1229532315 1751 dbSNP
rs1266926253 1770 dbSNP
rs186723306 1779 dbSNP
rs1356819501 1782 dbSNP
rs575516829 1784 dbSNP
rs1293608921 1786 dbSNP
rs1004961767 1787 dbSNP
rs1338593699 1788 dbSNP
rs577364312 1789 dbSNP
rs974333663 1806 dbSNP
rs1282132936 1814 dbSNP
rs1015433361 1823 dbSNP
rs919743913 1829 dbSNP
rs1367070056 1832 dbSNP
rs954109744 1833 dbSNP
rs985354866 1834 dbSNP
rs1014913828 1837 dbSNP
rs1249765639 1845 dbSNP
rs912269587 1863 dbSNP
rs543887990 1869 dbSNP
rs963410698 1877 dbSNP
rs995451821 1879 dbSNP
rs141485469 1880 dbSNP
rs750658699 1881 dbSNP
rs191082607 1882 dbSNP
rs1427244169 1888 dbSNP
rs1198821238 1890 dbSNP
rs969934923 1892 dbSNP
rs574974417 1903 dbSNP
rs1271322562 1905 dbSNP
rs913001194 1925 dbSNP
rs1437002822 1927 dbSNP
rs1273504839 1928 dbSNP
rs981095480 1931 dbSNP
rs559975704 1934 dbSNP
rs1261907789 1937 dbSNP
rs541351459 1938 dbSNP
rs1223599647 1940 dbSNP
rs528807367 1948 dbSNP
rs1286059965 1949 dbSNP
rs1441089731 1955 dbSNP
rs903981934 1956 dbSNP
rs1330008456 1957 dbSNP
rs1412086355 1962 dbSNP
rs1404551483 1966 dbSNP
rs551551674 1970 dbSNP
rs1470341792 1981 dbSNP
rs571467684 1987 dbSNP
rs1287652953 1988 dbSNP
rs1391438763 1994 dbSNP
rs1436329192 1995 dbSNP
rs1314780461 2002 dbSNP
rs1002906382 2004 dbSNP
rs1055375821 2014 dbSNP
rs770307156 2017 dbSNP
rs1129925 2023 dbSNP
rs1229681240 2024 dbSNP
rs1312939736 2034 dbSNP
rs1013575356 2049 dbSNP
rs1015581451 2050 dbSNP
rs1269985812 2052 dbSNP
rs1280447418 2060 dbSNP
rs1381127045 2066 dbSNP
rs1465290879 2066 dbSNP
rs550625489 2066 dbSNP
rs866960521 2069 dbSNP
rs1454028134 2074 dbSNP
rs922203535 2080 dbSNP
rs1157047694 2083 dbSNP
rs1400288054 2087 dbSNP
rs1408994378 2090 dbSNP
rs933558669 2092 dbSNP
rs1241053415 2100 dbSNP
rs995572872 2102 dbSNP
rs1473615882 2104 dbSNP
rs1184097176 2113 dbSNP
rs1027236286 2114 dbSNP
rs1183845350 2114 dbSNP
rs1462622820 2123 dbSNP
rs1051800539 2128 dbSNP
rs567266815 2130 dbSNP
rs886403818 2131 dbSNP
rs953901032 2139 dbSNP
rs536230690 2141 dbSNP
rs552737647 2148 dbSNP
rs898338713 2154 dbSNP
rs1357713540 2155 dbSNP
rs912467545 2157 dbSNP
rs574707280 2158 dbSNP
rs1247295588 2164 dbSNP
rs1381992361 2167 dbSNP
rs965241655 2169 dbSNP
rs1430103285 2170 dbSNP
rs1345925276 2173 dbSNP
rs1320512733 2176 dbSNP
rs77515659 2178 dbSNP
rs759027550 2184 dbSNP
rs1384336482 2200 dbSNP
rs1164004801 2203 dbSNP
rs878878772 2209 dbSNP
rs912864434 2210 dbSNP
rs1156994151 2214 dbSNP
rs1414912782 2215 dbSNP
rs1417306571 2220 dbSNP
rs1185924451 2227 dbSNP
rs766624114 2233 dbSNP
rs538891528 2240 dbSNP
rs1042807044 2246 dbSNP
rs925475339 2250 dbSNP
rs938178835 2256 dbSNP
rs955683971 2260 dbSNP
rs1291431411 2261 dbSNP
rs1223702367 2262 dbSNP
rs1404403497 2268 dbSNP
rs1055406608 2269 dbSNP
rs896760135 2270 dbSNP
rs1294047604 2275 dbSNP
rs749166777 2282 dbSNP
rs1303122041 2296 dbSNP
rs183157541 2303 dbSNP
rs1280210156 2316 dbSNP
rs1362720244 2316 dbSNP
rs1403283910 2330 dbSNP
rs1221645284 2335 dbSNP
rs575481955 2345 dbSNP
rs968480686 2354 dbSNP
rs1037045562 2357 dbSNP
rs975356815 2360 dbSNP
rs922117101 2364 dbSNP
rs1222823777 2367 dbSNP
rs543803910 2368 dbSNP
rs1429090053 2370 dbSNP
rs1420972634 2377 dbSNP
rs1196674341 2383 dbSNP
rs933566563 2404 dbSNP
rs1269157147 2406 dbSNP
rs1201211859 2417 dbSNP
rs897117731 2420 dbSNP
rs996035313 2421 dbSNP
rs1308623117 2422 dbSNP
rs542618824 2424 dbSNP
rs1221770464 2425 dbSNP
rs1345039576 2434 dbSNP
rs1480426470 2437 dbSNP
rs899269811 2438 dbSNP
rs948159019 2443 dbSNP
rs1370868802 2446 dbSNP
rs1180214496 2460 dbSNP
rs889647458 2462 dbSNP
rs769343795 2463 dbSNP
rs1044654207 2478 dbSNP
rs905666029 2481 dbSNP
rs1002765028 2482 dbSNP
rs1178109678 2483 dbSNP
rs1416976367 2486 dbSNP
rs1035543343 2499 dbSNP
rs1472936304 2512 dbSNP
rs1006661861 2515 dbSNP
rs1423660733 2517 dbSNP
rs557409742 2521 dbSNP
rs1202388475 2525 dbSNP
rs1322884530 2527 dbSNP
rs891702150 2528 dbSNP
rs1235637056 2532 dbSNP
rs1867 2533 dbSNP
rs1305953657 2541 dbSNP
rs1177241808 2552 dbSNP
rs1021290681 2557 dbSNP
rs1334583494 2561 dbSNP
rs1388982017 2567 dbSNP
rs543005983 2568 dbSNP
rs747910593 2579 dbSNP
rs1173842317 2584 dbSNP
rs559529725 2589 dbSNP
rs1020409906 2593 dbSNP
rs968403120 2597 dbSNP
rs978945626 2608 dbSNP
rs927042913 2612 dbSNP
rs572912037 2614 dbSNP
rs375732310 2618 dbSNP
rs974487000 2618 dbSNP
rs937064446 2620 dbSNP
rs954834331 2624 dbSNP
rs1461284887 2635 dbSNP
rs987733369 2635 dbSNP
rs545250729 2638 dbSNP
rs1219656003 2643 dbSNP
rs1272042346 2644 dbSNP
rs940934021 2652 dbSNP
rs973851418 2672 dbSNP
rs373382913 2680 dbSNP
rs918058503 2681 dbSNP
rs1245096109 2685 dbSNP
rs116923686 2686 dbSNP
rs1335546247 2688 dbSNP
rs1037284234 2694 dbSNP
rs139877318 2699 dbSNP
rs1421178820 2701 dbSNP
rs1362797610 2708 dbSNP
rs905718789 2709 dbSNP
rs1444500429 2715 dbSNP
rs772874419 2717 dbSNP
rs1245550907 2718 dbSNP
rs1426797948 2724 dbSNP
rs113330842 2725 dbSNP
rs1217572613 2727 dbSNP
rs561018705 2730 dbSNP
rs764002804 2733 dbSNP
rs1006894395 2736 dbSNP
rs1289253273 2740 dbSNP
rs891754806 2743 dbSNP
rs529789506 2744 dbSNP
rs1225218723 2746 dbSNP
rs145329710 2749 dbSNP
rs1295709391 2751 dbSNP
rs1401405770 2752 dbSNP
rs1363339981 2757 dbSNP
rs566426082 2773 dbSNP
rs538657428 2777 dbSNP
rs901008903 2786 dbSNP
rs114837647 2800 dbSNP
rs1020187794 2801 dbSNP
rs1423496488 2810 dbSNP
rs1165483558 2812 dbSNP
rs968811998 2813 dbSNP
rs1194495147 2817 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions TZM-bl
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM1462574. RNA binding protein: AGO2. Condition:TZM-bl ami BaL ...

- Whisnant AW; Bogerd HP; Flores O; Ho P; et al., 2013, mBio.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' gaguggacucgaGGGCACGGAc 5'
                      | ||||||| 
Target 5' ------------CACGUGCCUg 3'
 		1 - 10
Article - Whisnant AW; Bogerd HP; Flores O; Ho P; et al.
- mBio, 2013
UNLABELLED: The question of how HIV-1 interfaces with cellular microRNA (miRNA) biogenesis and effector mechanisms has been highly controversial. Here, we first used deep sequencing of small RNAs present in two different infected cell lines (TZM-bl and C8166) and two types of primary human cells (CD4(+) peripheral blood mononuclear cells [PBMCs] and macrophages) to unequivocally demonstrate that HIV-1 does not encode any viral miRNAs. Perhaps surprisingly, we also observed that infection of T cells by HIV-1 has only a modest effect on the expression of cellular miRNAs at early times after infection. Comprehensive analysis of miRNA binding to the HIV-1 genome using the photoactivatable ribonucleoside-induced cross-linking and immunoprecipitation (PAR-CLIP) technique revealed several binding sites for cellular miRNAs, a subset of which were shown to be capable of mediating miRNA-mediated repression of gene expression. However, the main finding from this analysis is that HIV-1 transcripts are largely refractory to miRNA binding, most probably due to extensive viral RNA secondary structure. Together, these data demonstrate that HIV-1 neither encodes viral miRNAs nor strongly influences cellular miRNA expression, at least early after infection, and imply that HIV-1 transcripts have evolved to avoid inhibition by preexisting cellular miRNAs by adopting extensive RNA secondary structures that occlude most potential miRNA binding sites. IMPORTANCE: MicroRNAs (miRNAs) are a ubiquitous class of small regulatory RNAs that serve as posttranscriptional regulators of gene expression. Previous work has suggested that HIV-1 might subvert the function of the cellular miRNA machinery by expressing viral miRNAs or by dramatically altering the level of cellular miRNA expression. Using very sensitive approaches, we now demonstrate that neither of these ideas is in fact correct. Moreover, HIV-1 transcripts appear to largely avoid regulation by cellular miRNAs by adopting an extensive RNA secondary structure that occludes the ability of cellular miRNAs to interact with viral mRNAs. Together, these data suggest that HIV-1, rather than seeking to control miRNA function in infected cells, has instead evolved a mechanism to become largely invisible to cellular miRNA effector mechanisms.
LinkOut: [PMID: 23592263]
CLIP-seq Support 1 for dataset GSM4903833
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / CTL_TD_21_a
Location of target site NM_005226 | 3UTR | UACUAAAAAUACAAAAAUUAGCUGGAUGCGAUAGCACGUGCCUGUAGUCCCAGCUACUCGGGAGGCUGAGGCUGGAGAGUUGCUCAAACCCGGGAGGCGGAGAUUGCAGUGAGCCAAGAUCGCACCGCUGCACUCCAGCCUGG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM4903835
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / CTL_TD_21_c
Location of target site NM_005226 | 3UTR | AAAAUUAGCUGGAUGCGAUAGCAC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 3 for dataset GSM4903836
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / 124_TD_21_a
Location of target site NM_005226 | 3UTR | GGGAGGCUGAGGCGGGUGGAUCACCUGAGGUCAGGAGUUUGUGACCAGCCUGGCCAACAUAGUGAAAUCCUGUUUCUACUAAAAAUACAAAAAUUAGCUGGAUGCGAUAGCACGUGCCUGUAGUCCCAGCUACUCGGGAGGCUGAGGCUGGAGAGUUGCUCAAACCCGGGAGGCGGAGAUUGCAGUGAGCCAAGAUCGCACCGCUGCACUCCAGCCUGG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 4 for dataset GSM4903837
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / 124_TD_21_b
Location of target site NM_005226 | 3UTR | GUAAUCCCAGCACUUUGGGAGGCUGAGGCGGGUGGAUCACCUGAGGUCAGGAGUUUGUGACCAGCCUGGCCAACAUAGUGAAAUCCUGUUUCUACUAAAAAUACAAAAAUUAGCUGGAUGCGAUAGCACGUGCCUGUAGUCCCAGCUACUCGGGAGGCUGAGGCUGGAGAGUUGCUCAAACCCGGGAGGCGGAGAUUGCAGUGAGCCAAGAUCGCACCGCUGCACUCCAGCCUGG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 5 for dataset GSM4903838
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / 124_TD_21_c
Location of target site NM_005226 | 3UTR | CACUUUGGGAGGCUGAGGCGGGUGGAUCACCUGAGGUCAGGAGUUUGUGACCAGCCUGGCCAACAUAGUGAAAUCCUGUUUCUACUAAAAAUACAAAAAUUAGCUGGAUGCGAUAGCACGUGCCUGUAGUCCCAGCUACUCGGGAGGCUGAGGCUGGAGAGUUGCUCAAACCCGGGAGGCGGAGAUUGCAGUGAGCCAAGAUCGCACCGCUGCACUCCAGCCUGG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 6 for dataset GSM1462574
Method / RBP PAR-CLIP / AGO2
Cell line / Condition TZM-bl / TZM-bl ami BaL
Location of target site ENST00000358157.2 | 3UTR | CACGUGCCUGUAGUCCCAGCUACUCGGGAGGCUGAGGCUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23592263 / GSE59944
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
THCA -0.298 0.24 -0.262 0.27 8 Click to see details
THCA -0.298 0.24 -0.262 0.27 8 Click to see details
THCA -0.298 0.24 -0.262 0.27 8 Click to see details
THCA -0.298 0.24 -0.262 0.27 8 Click to see details
THCA -0.298 0.24 -0.262 0.27 8 Click to see details
THCA -0.298 0.24 -0.262 0.27 8 Click to see details
THCA -0.298 0.24 -0.262 0.27 8 Click to see details
61 hsa-miR-3622a-5p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT166678 ZSWIM6 zinc finger SWIM-type containing 6 2 2
MIRT452081 ATP6V0B ATPase H+ transporting V0 subunit b 2 2
MIRT457039 S1PR3 sphingosine-1-phosphate receptor 3 2 2
MIRT471975 NR3C1 nuclear receptor subfamily 3 group C member 1 2 2
MIRT474065 LMNB2 lamin B2 2 2
MIRT475862 H6PD hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase 2 2
MIRT476191 GOLGA8A golgin A8 family member A 2 2
MIRT476521 GABRB1 gamma-aminobutyric acid type A receptor beta1 subunit 2 2
MIRT483046 C15orf52 chromosome 15 open reading frame 52 2 4
MIRT495541 EIF3H eukaryotic translation initiation factor 3 subunit H 2 2
MIRT495892 CLOCK clock circadian regulator 2 2
MIRT495992 LTBP2 latent transforming growth factor beta binding protein 2 2 2
MIRT496001 EMP1 epithelial membrane protein 1 2 2
MIRT496208 PLEKHG2 pleckstrin homology and RhoGEF domain containing G2 2 2
MIRT496427 ACTRT3 actin related protein T3 2 2
MIRT496438 ZNF704 zinc finger protein 704 2 2
MIRT496473 SDE2 SDE2 telomere maintenance homolog 2 2
MIRT496555 TBX15 T-box 15 2 2
MIRT497202 CECR1 adenosine deaminase 2 2 2
MIRT507632 CREBZF CREB/ATF bZIP transcription factor 2 2
MIRT513377 MGAT4A mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A 2 2
MIRT523460 GOLGA8J golgin A8 family member J 2 2
MIRT523465 GOLGA8I golgin A8 family member I, pseudogene 1 1
MIRT526049 GMDS GDP-mannose 4,6-dehydratase 2 2
MIRT533122 YIPF4 Yip1 domain family member 4 2 2
MIRT534183 SLC8A1 solute carrier family 8 member A1 2 2
MIRT556618 LCOR ligand dependent nuclear receptor corepressor 2 2
MIRT563361 WHSC1 nuclear receptor binding SET domain protein 2 2 2
MIRT563868 FAM206A family with sequence similarity 206 member A 2 2
MIRT564360 PPWD1 peptidylprolyl isomerase domain and WD repeat containing 1 2 2
MIRT564661 ZNF449 zinc finger protein 449 2 2
MIRT564805 ZBTB33 zinc finger and BTB domain containing 33 2 2
MIRT564867 ZBED3 zinc finger BED-type containing 3 2 2
MIRT565340 TMEM104 transmembrane protein 104 2 2
MIRT566439 PHF16 jade family PHD finger 3 2 2
MIRT567587 FCHSD2 FCH and double SH3 domains 2 2 2
MIRT569597 C3orf62 chromosome 3 open reading frame 62 2 2
MIRT569700 FMNL3 formin like 3 2 2
MIRT575957 Nanos1 nanos homolog 1 (Drosophila) 2 3
MIRT576516 Slc35e2 solute carrier family 35, member E2 2 2
MIRT608480 RRP36 ribosomal RNA processing 36 2 2
MIRT614335 NANOS1 nanos C2HC-type zinc finger 1 2 3
MIRT630816 ATAT1 alpha tubulin acetyltransferase 1 2 4
MIRT631708 C1QTNF6 C1q and TNF related 6 2 2
MIRT632369 SRRD SRR1 domain containing 2 2
MIRT633471 DSN1 DSN1 homolog, MIS12 kinetochore complex component 2 2
MIRT634478 PAFAH1B2 platelet activating factor acetylhydrolase 1b catalytic subunit 2 2 2
MIRT667336 MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like 2 2
MIRT667654 LFNG LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase 2 2
MIRT671046 SS18 SS18, nBAF chromatin remodeling complex subunit 2 2
MIRT672823 VEZT vezatin, adherens junctions transmembrane protein 2 2
MIRT673049 SGPL1 sphingosine-1-phosphate lyase 1 2 2
MIRT673435 APAF1 apoptotic peptidase activating factor 1 2 2
MIRT676096 DPP9 dipeptidyl peptidase 9 2 2
MIRT678059 RPL7L1 ribosomal protein L7 like 1 2 2
MIRT679783 GOLGA2 golgin A2 2 2
MIRT684219 C9orf64 chromosome 9 open reading frame 64 2 2
MIRT697642 WRN Werner syndrome RecQ like helicase 2 2
MIRT706595 C1RL complement C1r subcomponent like 2 2
MIRT706603 CCS copper chaperone for superoxide dismutase 2 2
MIRT717647 HLX H2.0 like homeobox 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-3622a Doxorubicin 31703 NSC123127 approved resistant High Hepatocellular Carcinoma cell line (HepG2)
hsa-mir-3622a Paclitaxel 36314 NSC125973 approved resistant cell line (W1)
hsa-miR-3622a-5p Paclitaxel 36314 NSC125973 approved resistant High Non-Small Cell Lung Cancer cell line (A549)
hsa-miR-3622a-5p Osimertinib 71496458 NSC779217 approved resistant cell line (PC9)
hsa-miR-3622a-5p Osimertinib 71496458 NSC779217 approved resistant cell line (HCC827)
hsa-miR-3622a-5p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-3622a-5p Gefitinib 123631 NSC715055 approved sensitive cell line (HCC827)
hsa-miR-3622a-5p Osimertinib 71496458 NSC779217 approved sensitive cell line (H1975)
hsa-miR-3622a-5p Cisplatin 5460033 NSC119875 approved sensitive cell line (MGC-803)
hsa-miR-3622a-5p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-3622a-5p Gemcitabine 60750 NSC613327 approved sensitive cell line (PANC-1) (1500 ng/ml)
hsa-miR-3622a-5p Gemcitabine 60750 NSC613327 approved sensitive cell line (PANC-1) (100 ng/ml)
hsa-miR-3622a-5p Gemcitabine 60750 NSC613327 approved sensitive cell line (Panc1-GR3)
hsa-miR-3622a-5p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)

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