miRTarBase - #MIRT457223


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pre-miRNA Information
pre-miRNA hsa-mir-4747   
Genomic Coordinates chr19: 4932687 - 4932740
Description Homo sapiens miR-4747 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-4747-5p
Sequence 1| AGGGAAGGAGGCUUGGUCUUAG |22
Evidence Experimental
Experiments Illumina
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs560927363 4 dbSNP
rs1471226927 10 dbSNP
rs763137545 12 dbSNP
rs767337154 15 dbSNP
rs775298039 16 dbSNP
rs760472311 19 dbSNP
rs1207950315 21 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol AP3D1   
Synonyms ADTD, HPS10, hBLVR
Description adaptor related protein complex 3 delta 1 subunit
Transcript NM_003938   
Expression
Putative miRNA Targets on AP3D1
3'UTR of AP3D1
(miRNA target sites are highlighted)		 
>AP3D1|NM_003938|3'UTR
   1 GAGCTGCCTGCGAGCCCCGCACCACCCCGCGGAGCACGTACCCAGGGACCGCAGCCCTGACGTGTCTCGCCTCTCCTCAG
  81 TCGTGTGTACTGTACCCAAGCCTGAGTGTTAATTTAACTCTATGTTGTCCGCCGTGTAGACATCCGAGGTCATTTGTTGC
 161 GTTGAATTATCTGACCATCCTTTTTTACTGTGACTCTTCCCATTCTCTTTGGCAAGAAGTCCCCTTCTCGCCCCCAAACC
 241 AGCAAGGGACTCCCCCACCTGGGTCTGTGCCCTGCCCCGCGCTGGGGGCCGAGTCCTTGAATGTGGCTTCAGGGGCTCCT
 321 GTCCTGGGCCAGGGCCTGATGGGCACCACGTGAGGGGCACTTGGTGGACAGGGCGGGGCTGACGTGGCCTCCTCTGGGGT
 401 CGCCTGCTTTTGACCCAAAGGTCCTGACGGTTGCGTCCGGGGGAGGGGAAGGAAGGGCCGCTGTCGCCAAGGTTTTCTCT
 481 CCCAGAACCCACAGTGGGAAAGCGGTCTTGCCAGGCGTTGTCCATTGTCAGTGTGCTCGTGGGCTGGTGACTGGGTCTTG
 561 GGATCCCAGGCCACGCGCCAGCCAGGCTGTGGGCAGGGCGGGGCCAGGGACGCCAAAGAGAGGTTGCAGTCAGAACCGTG
 641 GACGGGGTGGGTTGAGGCCTCTCTGCCACCCGTCTTCCTGGTCAGCAGAAGTGCATCTCGGCTTGGGTTTGGGGTGGTCC
 721 GCATCCCCTGCTTGCCACTATGCGCACCAAGGTTTCCCCACATCCTTCCCAGCACCCTTAGGAAGGCCCAGGCAGGGCCT
 801 GGAAGCAGCGGACCTGGGCTGTTCTGTGTTGAAGGAGTGTGCCCAGTGCCCTTGGGCAGGACCTGTGAGAGCCACCTCAC
 881 AGGCAGAGCCCCCACCAGGCAGGGCAAGGAGACTCCGCTCACTCCCCACGGCCAGCGTGGGCACAGGACTGACCCTTCTT
 961 CAGAGATAATGACATTTTATCTTCTCCTTTTGATGAAAACTGTCACTTTAGCATGTAATCCATTACAGAATCCCATGCAG
1041 TGATTCCAGGATTTGAAATTGTATGATGTGTTACATAAGAATTTATTTGCTATCGACATTCCCGTATAAAGAGAGAGACA
1121 TATCACGCTGCTGTCATGATTTTGTGTCAAGATGATCCAATAAAGTTGTAAAACAGGCATTTCCAAAAAAAAAAAAAAAA
1201 AA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' gauucUGGUUC------GG---AGGAAGGGa 5'
               ||||||      ||   |||||||| 
Target 5' tgcgcACCAAGGTTTCCCCACATCCTTCCCa 3'
 741 - 771 155.00 -18.30
2 
miRNA  3' gaUUCUGGUUCGGAGGAAGGGa 5'
            |||   |||:| |||||:| 
Target 5' gcAAG---AAGTCCCCTTCTCg 3'
 212 - 230 145.00 -14.30
3 
miRNA  3' gauucUGGUUCGGAGGAAGGGa 5'
               ||:: | | :|||||| 
Target 5' tttttACTGTGAC-TCTTCCCa 3'
 182 - 202 132.00 -12.31
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN26966317 12 COSMIC
COSN31491021 15 COSMIC
COSN30497874 19 COSMIC
COSN30111000 31 COSMIC
COSN30191939 31 COSMIC
COSN26966319 36 COSMIC
COSN31589185 50 COSMIC
COSN30473930 97 COSMIC
COSN5850136 151 COSMIC
COSN1212649 329 COSMIC
COSN1762538 559 COSMIC
COSN6139645 672 COSMIC
COSN26574639 1050 COSMIC
rs113462542 717 GWAS
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1188516320 1 dbSNP
rs770142224 7 dbSNP
rs563077165 11 dbSNP
rs199607685 12 dbSNP
rs1488533062 14 dbSNP
rs1218339976 15 dbSNP
rs1285200790 16 dbSNP
rs576247354 18 dbSNP
rs779300700 19 dbSNP
rs1264962557 20 dbSNP
rs1423661035 22 dbSNP
rs764830144 23 dbSNP
rs761392853 26 dbSNP
rs753576154 28 dbSNP
rs200388931 29 dbSNP
rs180893127 30 dbSNP
rs1319810455 31 dbSNP
rs774982238 34 dbSNP
rs1389322993 35 dbSNP
rs113163611 37 dbSNP
rs763339870 38 dbSNP
rs1421384038 40 dbSNP
rs1169950195 41 dbSNP
rs773737553 45 dbSNP
rs189353877 50 dbSNP
rs748289680 51 dbSNP
rs371250099 52 dbSNP
rs1453125373 61 dbSNP
rs186478213 62 dbSNP
rs1241479941 68 dbSNP
rs1048794241 69 dbSNP
rs1187741339 75 dbSNP
rs138030639 76 dbSNP
rs1011498776 80 dbSNP
rs1163896225 82 dbSNP
rs893032434 83 dbSNP
rs930422715 87 dbSNP
rs1399350171 91 dbSNP
rs1158950553 92 dbSNP
rs1346280393 93 dbSNP
rs1382028675 97 dbSNP
rs916402335 120 dbSNP
rs534857382 122 dbSNP
rs1453577562 126 dbSNP
rs755789289 130 dbSNP
rs1052995124 131 dbSNP
rs1221882474 133 dbSNP
rs934470800 134 dbSNP
rs1443726862 135 dbSNP
rs901956775 142 dbSNP
rs1801941 145 dbSNP
rs943409711 146 dbSNP
rs960590669 152 dbSNP
rs910559187 156 dbSNP
rs927842859 160 dbSNP
rs1409254163 161 dbSNP
rs1402939368 169 dbSNP
rs1174922919 170 dbSNP
rs1405355767 170 dbSNP
rs978010863 175 dbSNP
rs930944483 176 dbSNP
rs1441807011 177 dbSNP
rs1278735492 182 dbSNP
rs533782514 209 dbSNP
rs1373865856 216 dbSNP
rs756184415 223 dbSNP
rs1230094957 225 dbSNP
rs552301678 227 dbSNP
rs966663126 229 dbSNP
rs1322148170 230 dbSNP
rs1203723268 231 dbSNP
rs1280173177 234 dbSNP
rs1435709544 235 dbSNP
rs1180717560 250 dbSNP
rs1022346731 254 dbSNP
rs111620579 256 dbSNP
rs1197841083 258 dbSNP
rs1429230822 272 dbSNP
rs972283869 274 dbSNP
rs954301590 276 dbSNP
rs537170302 278 dbSNP
rs537645905 279 dbSNP
rs1245929647 280 dbSNP
rs1384236992 286 dbSNP
rs1354834662 289 dbSNP
rs1315248242 290 dbSNP
rs752713478 291 dbSNP
rs901346870 292 dbSNP
rs1224113316 296 dbSNP
rs570637343 310 dbSNP
rs981177166 311 dbSNP
rs1037204257 315 dbSNP
rs1194809762 318 dbSNP
rs1287932049 323 dbSNP
rs969743630 330 dbSNP
rs1220690828 339 dbSNP
rs1022618028 347 dbSNP
rs1011654481 349 dbSNP
rs1453784698 350 dbSNP
rs199644637 355 dbSNP
rs1371352663 356 dbSNP
rs781414439 366 dbSNP
rs552375880 372 dbSNP
rs886098514 373 dbSNP
rs1168672510 374 dbSNP
rs755186592 375 dbSNP
rs1161549415 377 dbSNP
rs1423017175 378 dbSNP
rs930390586 383 dbSNP
rs1364793654 387 dbSNP
rs1405418968 388 dbSNP
rs916293096 390 dbSNP
rs1054896403 397 dbSNP
rs939147579 401 dbSNP
rs1226083919 402 dbSNP
rs538197629 402 dbSNP
rs1343820243 404 dbSNP
rs527752704 412 dbSNP
rs1243403625 416 dbSNP
rs1291488369 421 dbSNP
rs1490620629 422 dbSNP
rs36026505 423 dbSNP
rs1426584999 424 dbSNP
rs978002516 428 dbSNP
rs1207596927 429 dbSNP
rs1193950057 433 dbSNP
rs966653261 434 dbSNP
rs1442991154 435 dbSNP
rs560309626 438 dbSNP
rs77546082 439 dbSNP
rs1040191096 442 dbSNP
rs1266826483 443 dbSNP
rs1382663028 444 dbSNP
rs1007657665 449 dbSNP
rs767258716 450 dbSNP
rs1366810593 453 dbSNP
rs1449940253 458 dbSNP
rs989506875 459 dbSNP
rs879259214 460 dbSNP
rs1247477948 461 dbSNP
rs73512331 464 dbSNP
rs1028790961 465 dbSNP
rs563166730 466 dbSNP
rs976863739 469 dbSNP
rs919649546 471 dbSNP
rs1206295858 482 dbSNP
rs1249909457 485 dbSNP
rs1460039838 487 dbSNP
rs1225618400 503 dbSNP
rs919549774 504 dbSNP
rs965924633 506 dbSNP
rs1294351993 507 dbSNP
rs1400255353 511 dbSNP
rs939584125 516 dbSNP
rs1300718355 517 dbSNP
rs1361917873 523 dbSNP
rs544867198 525 dbSNP
rs1391356165 538 dbSNP
rs1015748676 544 dbSNP
rs1004408698 559 dbSNP
rs577493588 560 dbSNP
rs565443482 566 dbSNP
rs750224826 571 dbSNP
rs1170933325 573 dbSNP
rs994883207 574 dbSNP
rs915641016 575 dbSNP
rs138889655 576 dbSNP
rs1240300347 579 dbSNP
rs1270609077 585 dbSNP
rs1055243853 593 dbSNP
rs1203088824 594 dbSNP
rs146387349 599 dbSNP
rs753818782 600 dbSNP
rs559445973 606 dbSNP
rs945259520 611 dbSNP
rs182020378 615 dbSNP
rs1480485887 616 dbSNP
rs989418969 631 dbSNP
rs932602978 637 dbSNP
rs774214128 638 dbSNP
rs535419044 643 dbSNP
rs977233513 646 dbSNP
rs1281053496 651 dbSNP
rs1359291732 656 dbSNP
rs1467206567 659 dbSNP
rs1007396271 663 dbSNP
rs889229274 665 dbSNP
rs1222303691 671 dbSNP
rs1290649170 672 dbSNP
rs965461091 674 dbSNP
rs1331192323 675 dbSNP
rs1015696322 677 dbSNP
rs372372067 699 dbSNP
rs574435176 700 dbSNP
rs1480161988 703 dbSNP
rs1395748554 707 dbSNP
rs1331775463 708 dbSNP
rs1027159715 711 dbSNP
rs201412030 713 dbSNP
rs199606019 715 dbSNP
rs113462542 718 dbSNP
rs3831627 718 dbSNP
rs894802377 720 dbSNP
rs897840173 721 dbSNP
rs1434427821 725 dbSNP
rs1033387485 735 dbSNP
rs1372119946 740 dbSNP
rs1404098965 741 dbSNP
rs368285095 743 dbSNP
rs972839589 744 dbSNP
rs1294637633 746 dbSNP
rs1042181364 747 dbSNP
rs945155661 750 dbSNP
rs893644803 751 dbSNP
rs1251937977 752 dbSNP
rs1054108034 772 dbSNP
rs948208472 773 dbSNP
rs75372425 775 dbSNP
rs866415380 781 dbSNP
rs1221596525 785 dbSNP
rs537682602 786 dbSNP
rs1247238308 791 dbSNP
rs1260798331 793 dbSNP
rs1489450620 795 dbSNP
rs935724899 796 dbSNP
rs924278770 797 dbSNP
rs1202665490 798 dbSNP
rs1449685270 802 dbSNP
rs1170109126 805 dbSNP
rs1424463438 807 dbSNP
rs775094498 809 dbSNP
rs1429295621 810 dbSNP
rs944060053 814 dbSNP
rs908603841 828 dbSNP
rs142326157 831 dbSNP
rs1309893530 846 dbSNP
rs985992159 848 dbSNP
rs1227507726 853 dbSNP
rs953206623 856 dbSNP
rs552322131 858 dbSNP
rs1323427960 871 dbSNP
rs920147245 875 dbSNP
rs1027467397 887 dbSNP
rs1213624132 887 dbSNP
rs1464960569 888 dbSNP
rs995335831 889 dbSNP
rs1336280304 890 dbSNP
rs897900115 894 dbSNP
rs992144228 903 dbSNP
rs1003480157 904 dbSNP
rs1156876484 906 dbSNP
rs1453228740 908 dbSNP
rs959017115 916 dbSNP
rs1181066534 917 dbSNP
rs1159018773 918 dbSNP
rs1443110973 920 dbSNP
rs1045301962 929 dbSNP
rs771657855 930 dbSNP
rs1334850087 932 dbSNP
rs534040476 935 dbSNP
rs1284555522 936 dbSNP
rs1449116552 936 dbSNP
rs1381092014 940 dbSNP
rs1221937288 951 dbSNP
rs1053924246 953 dbSNP
rs1804844 963 dbSNP
rs1280382480 974 dbSNP
rs1260754305 978 dbSNP
rs1003188423 980 dbSNP
rs1202788147 981 dbSNP
rs1210463420 987 dbSNP
rs935784560 989 dbSNP
rs138416315 1002 dbSNP
rs1177084576 1004 dbSNP
rs1801940 1007 dbSNP
rs1020674630 1021 dbSNP
rs1801939 1027 dbSNP
rs1009357302 1034 dbSNP
rs1286592439 1043 dbSNP
rs893633719 1048 dbSNP
rs1473880517 1049 dbSNP
rs1405513911 1053 dbSNP
rs1415196910 1064 dbSNP
rs1242271182 1065 dbSNP
rs944342858 1068 dbSNP
rs1314077169 1075 dbSNP
rs1053654300 1077 dbSNP
rs143700949 1081 dbSNP
rs1448552189 1086 dbSNP
rs1342478380 1091 dbSNP
rs997147795 1092 dbSNP
rs771315013 1094 dbSNP
rs1361272373 1095 dbSNP
rs1160931680 1097 dbSNP
rs1423256106 1099 dbSNP
rs1801938 1101 dbSNP
rs148991383 1102 dbSNP
rs953284962 1103 dbSNP
rs749828717 1104 dbSNP
rs1343696395 1107 dbSNP
rs944007747 1110 dbSNP
rs1164196277 1111 dbSNP
rs1219402424 1115 dbSNP
rs908553009 1115 dbSNP
rs1280317632 1119 dbSNP
rs973256729 1119 dbSNP
rs1047133833 1123 dbSNP
rs757129171 1124 dbSNP
rs778258394 1126 dbSNP
rs770235000 1127 dbSNP
rs1377076160 1128 dbSNP
rs1487654969 1129 dbSNP
rs1263242734 1130 dbSNP
rs1218219463 1140 dbSNP
rs1174487270 1142 dbSNP
rs569600055 1144 dbSNP
rs1417612191 1160 dbSNP
rs551310340 1163 dbSNP
rs1409652765 1170 dbSNP
rs1307178439 1174 dbSNP
rs1371004920 1177 dbSNP
rs1411527262 1177 dbSNP
rs113152158 1178 dbSNP
rs113982605 1179 dbSNP
rs372892224 1185 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions TZM-bl
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM1462574. RNA binding protein: AGO2. Condition:TZM-bl ami BaL ...

- Whisnant AW; Bogerd HP; Flores O; Ho P; et al., 2013, mBio.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' gauucUGGUUCGGAGGAAGGGa 5'
               ||:: | | :|||||| 
Target 5' uuuuuACUGUGAC-UCUUCCCa 3'
 		9 - 29
Article - Whisnant AW; Bogerd HP; Flores O; Ho P; et al.
- mBio, 2013
UNLABELLED: The question of how HIV-1 interfaces with cellular microRNA (miRNA) biogenesis and effector mechanisms has been highly controversial. Here, we first used deep sequencing of small RNAs present in two different infected cell lines (TZM-bl and C8166) and two types of primary human cells (CD4(+) peripheral blood mononuclear cells [PBMCs] and macrophages) to unequivocally demonstrate that HIV-1 does not encode any viral miRNAs. Perhaps surprisingly, we also observed that infection of T cells by HIV-1 has only a modest effect on the expression of cellular miRNAs at early times after infection. Comprehensive analysis of miRNA binding to the HIV-1 genome using the photoactivatable ribonucleoside-induced cross-linking and immunoprecipitation (PAR-CLIP) technique revealed several binding sites for cellular miRNAs, a subset of which were shown to be capable of mediating miRNA-mediated repression of gene expression. However, the main finding from this analysis is that HIV-1 transcripts are largely refractory to miRNA binding, most probably due to extensive viral RNA secondary structure. Together, these data demonstrate that HIV-1 neither encodes viral miRNAs nor strongly influences cellular miRNA expression, at least early after infection, and imply that HIV-1 transcripts have evolved to avoid inhibition by preexisting cellular miRNAs by adopting extensive RNA secondary structures that occlude most potential miRNA binding sites. IMPORTANCE: MicroRNAs (miRNAs) are a ubiquitous class of small regulatory RNAs that serve as posttranscriptional regulators of gene expression. Previous work has suggested that HIV-1 might subvert the function of the cellular miRNA machinery by expressing viral miRNAs or by dramatically altering the level of cellular miRNA expression. Using very sensitive approaches, we now demonstrate that neither of these ideas is in fact correct. Moreover, HIV-1 transcripts appear to largely avoid regulation by cellular miRNAs by adopting an extensive RNA secondary structure that occludes the ability of cellular miRNAs to interact with viral mRNAs. Together, these data suggest that HIV-1, rather than seeking to control miRNA function in infected cells, has instead evolved a mechanism to become largely invisible to cellular miRNA effector mechanisms.
LinkOut: [PMID: 23592263]
CLIP-seq Support 1 for dataset GSM4903831
Method / RBP HITS-CLIP / AGO
Cell line / Condition Human neurons / 124TD_shELAVL3_a
Location of target site NM_001077523 | 3UTR | CCCACAUCCUUCCCAG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161238
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM1462574
Method / RBP PAR-CLIP / AGO2
Cell line / Condition TZM-bl / TZM-bl ami BaL
Location of target site ENST00000355272.6 | 3UTR | ACCAUCCUUUUUUACUGUGACUCUUCCCAUUCUCUUUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23592263 / GSE59944
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
215 hsa-miR-4747-5p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT061689 BTG2 BTG anti-proliferation factor 2 2 2
MIRT062834 BCL7A BCL tumor suppressor 7A 2 2
MIRT079371 CCDC137 coiled-coil domain containing 137 2 2
MIRT081190 MIDN midnolin 2 4
MIRT081724 ZNF507 zinc finger protein 507 2 2
MIRT110565 ZMYND11 zinc finger MYND-type containing 11 2 2
MIRT133724 SKI SKI proto-oncogene 2 4
MIRT146689 MINK1 misshapen like kinase 1 2 2
MIRT150676 SLC27A1 solute carrier family 27 member 1 2 2
MIRT159196 NRBP1 nuclear receptor binding protein 1 2 2
MIRT180865 RPRD2 regulation of nuclear pre-mRNA domain containing 2 2 2
MIRT190659 PABPN1 poly(A) binding protein nuclear 1 2 2
MIRT196111 MPRIP myosin phosphatase Rho interacting protein 2 2
MIRT232390 SP1 Sp1 transcription factor 2 2
MIRT331070 EIF5AL1 eukaryotic translation initiation factor 5A-like 1 2 4
MIRT338632 SHMT2 serine hydroxymethyltransferase 2 2 2
MIRT407441 CTDSP1 CTD small phosphatase 1 2 2
MIRT444276 NKX6-1 NK6 homeobox 1 2 2
MIRT444834 PDE6D phosphodiesterase 6D 2 2
MIRT445452 EXT1 exostosin glycosyltransferase 1 2 2
MIRT445644 NPY4R neuropeptide Y receptor Y4 2 2
MIRT446157 RPL12 ribosomal protein L12 2 2
MIRT446608 HIP1 huntingtin interacting protein 1 2 2
MIRT447108 CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit 2 2
MIRT449314 MRO maestro 2 2
MIRT450305 DRAXIN dorsal inhibitory axon guidance protein 2 2
MIRT451245 ZNF444 zinc finger protein 444 2 2
MIRT451714 OLR1 oxidized low density lipoprotein receptor 1 2 2
MIRT451908 ILK integrin linked kinase 2 2
MIRT452183 KIAA1456 KIAA1456 2 2
MIRT452610 REPIN1 replication initiator 1 2 2
MIRT453422 GLG1 golgi glycoprotein 1 2 2
MIRT454006 ALKBH5 alkB homolog 5, RNA demethylase 2 2
MIRT455072 ARHGAP39 Rho GTPase activating protein 39 2 2
MIRT455319 TTLL9 tubulin tyrosine ligase like 9 2 2
MIRT455357 KDM5C lysine demethylase 5C 2 2
MIRT455589 TAF12 TATA-box binding protein associated factor 12 2 2
MIRT455711 EIF4EBP2 eukaryotic translation initiation factor 4E binding protein 2 2 2
MIRT455860 TMEM254 transmembrane protein 254 2 2
MIRT455919 RAPGEF1 Rap guanine nucleotide exchange factor 1 2 2
MIRT455946 CYP4A22 cytochrome P450 family 4 subfamily A member 22 2 2
MIRT456935 LRP10 LDL receptor related protein 10 2 2
MIRT457223 AP3D1 adaptor related protein complex 3 delta 1 subunit 2 2
MIRT457431 NOL10 nucleolar protein 10 2 2
MIRT457470 SLC35F6 solute carrier family 35 member F6 2 2
MIRT457907 ZNF212 zinc finger protein 212 2 2
MIRT458046 TSEN54 tRNA splicing endonuclease subunit 54 2 2
MIRT458073 RNLS renalase, FAD dependent amine oxidase 2 2
MIRT458234 NXPH3 neurexophilin 3 2 2
MIRT458307 TNFAIP8L3 TNF alpha induced protein 8 like 3 2 2
MIRT458378 ITM2C integral membrane protein 2C 2 2
MIRT458967 ZNF436 zinc finger protein 436 2 2
MIRT459099 CYP4A11 cytochrome P450 family 4 subfamily A member 11 2 2
MIRT459446 TMEM37 transmembrane protein 37 2 2
MIRT459671 VPS37C VPS37C, ESCRT-I subunit 2 2
MIRT460727 ASXL3 additional sex combs like 3, transcriptional regulator 2 2
MIRT460744 SRP14 signal recognition particle 14 2 2
MIRT461531 C14orf1 ergosterol biosynthesis 28 homolog 2 2
MIRT461752 DDX11 DEAD/H-box helicase 11 2 2
MIRT461837 F2RL3 F2R like thrombin or trypsin receptor 3 2 2
MIRT462019 RIF1 replication timing regulatory factor 1 2 2
MIRT462631 PHF5A PHD finger protein 5A 2 2
MIRT462772 ZNF8 zinc finger protein 8 2 2
MIRT463032 ZNF689 zinc finger protein 689 2 2
MIRT463886 WNT7B Wnt family member 7B 2 2
MIRT463995 WDTC1 WD and tetratricopeptide repeats 1 2 2
MIRT464371 URM1 ubiquitin related modifier 1 2 2
MIRT465342 TPM3 tropomyosin 3 2 4
MIRT465515 PRICKLE4 prickle planar cell polarity protein 4 2 2
MIRT465602 TNRC6A trinucleotide repeat containing 6A 2 2
MIRT465697 TNPO2 transportin 2 2 10
MIRT466988 SSRP1 structure specific recognition protein 1 2 4
MIRT467630 SLC7A5 solute carrier family 7 member 5 2 2
MIRT468132 SH3PXD2A SH3 and PX domains 2A 2 2
MIRT468322 SF3B3 splicing factor 3b subunit 3 2 2
MIRT468502 SESN2 sestrin 2 2 2
MIRT468881 RREB1 ras responsive element binding protein 1 2 2
MIRT469322 RGP1 RGP1 homolog, RAB6A GEF complex partner 1 2 2
MIRT469562 RARA retinoic acid receptor alpha 2 2
MIRT469898 PTRF caveolae associated protein 1 2 2
MIRT470045 PTGFRN prostaglandin F2 receptor inhibitor 2 2
MIRT470068 PTGES2 prostaglandin E synthase 2 2 2
MIRT470238 PRRC2A proline rich coiled-coil 2A 2 2
MIRT470390 PPP1R16B protein phosphatase 1 regulatory subunit 16B 2 2
MIRT470500 PPP1R11 protein phosphatase 1 regulatory inhibitor subunit 11 2 2
MIRT470689 POLR2D RNA polymerase II subunit D 2 2
MIRT470704 POGK pogo transposable element derived with KRAB domain 2 2
MIRT471083 PIK3C2B phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta 2 2
MIRT472482 NACC2 NACC family member 2 2 2
MIRT473583 MAT2A methionine adenosyltransferase 2A 2 2
MIRT474554 KLHDC3 kelch domain containing 3 2 2
MIRT474651 KLF13 Kruppel like factor 13 2 2
MIRT474843 KHSRP KH-type splicing regulatory protein 2 2
MIRT474934 KCTD15 potassium channel tetramerization domain containing 15 2 2
MIRT475573 HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 2 2
MIRT476045 GRSF1 G-rich RNA sequence binding factor 1 2 2
MIRT476080 GRB2 growth factor receptor bound protein 2 2 2
MIRT476440 GBA2 glucosylceramidase beta 2 2 2
MIRT476764 FOSL2 FOS like 2, AP-1 transcription factor subunit 2 2
MIRT478785 CRTC2 CREB regulated transcription coactivator 2 2 2
MIRT479287 CHAC1 ChaC glutathione specific gamma-glutamylcyclotransferase 1 2 2
MIRT479505 CDH6 cadherin 6 2 2
MIRT479732 CCND1 cyclin D1 2 6
MIRT480352 C5orf24 chromosome 5 open reading frame 24 2 2
MIRT480407 C19orf47 chromosome 19 open reading frame 47 2 2
MIRT480859 BHLHB9 basic helix-loop-helix family member b9 2 2
MIRT481445 ARRB2 arrestin beta 2 2 2
MIRT481732 APH1A aph-1 homolog A, gamma-secretase subunit 2 2
MIRT481824 AP2M1 adaptor related protein complex 2 mu 1 subunit 2 2
MIRT482566 ABHD2 abhydrolase domain containing 2 2 2
MIRT482607 ABHD14B abhydrolase domain containing 14B 2 2
MIRT483144 SYCE1L synaptonemal complex central element protein 1 like 2 2
MIRT483214 APOA1 apolipoprotein A1 2 6
MIRT483878 TGIF1 TGFB induced factor homeobox 1 2 2
MIRT483917 SPSB1 splA/ryanodine receptor domain and SOCS box containing 1 2 2
MIRT483939 LENG8 leukocyte receptor cluster member 8 2 4
MIRT484420 SNX19 sorting nexin 19 2 2
MIRT484489 SLC9A1 solute carrier family 9 member A1 2 2
MIRT484612 SIX3 SIX homeobox 3 2 6
MIRT484705 RNF11 ring finger protein 11 2 2
MIRT485107 SHISA6 shisa family member 6 2 2
MIRT485354 MYO1C myosin IC 2 4
MIRT485609 FOSL1 FOS like 1, AP-1 transcription factor subunit 2 4
MIRT487311 GLTSCR1 BRD4 interacting chromatin remodeling complex associated protein 2 2
MIRT487417 CACNB1 calcium voltage-gated channel auxiliary subunit beta 1 2 2
MIRT487695 CDK14 cyclin dependent kinase 14 2 2
MIRT487791 GPR20 G protein-coupled receptor 20 2 4
MIRT488042 PABPC1L2B poly(A) binding protein cytoplasmic 1 like 2B 2 2
MIRT488058 PABPC1L2A poly(A) binding protein cytoplasmic 1 like 2A 2 2
MIRT488237 DNLZ DNL-type zinc finger 2 4
MIRT488764 FXYD1 FXYD domain containing ion transport regulator 1 2 2
MIRT489401 TUBB2A tubulin beta 2A class IIa 2 2
MIRT489777 GRINA glutamate ionotropic receptor NMDA type subunit associated protein 1 2 2
MIRT490099 FN3K fructosamine 3 kinase 2 2
MIRT490290 ISL2 ISL LIM homeobox 2 2 2
MIRT490378 LHFPL3 LHFPL tetraspan subfamily member 3 2 2
MIRT491329 GFER growth factor, augmenter of liver regeneration 2 2
MIRT491435 MSX2 msh homeobox 2 2 2
MIRT491769 ZNF385A zinc finger protein 385A 2 2
MIRT491922 WNK2 WNK lysine deficient protein kinase 2 2 2
MIRT491983 UNK unkempt family zinc finger 2 2
MIRT492228 SLC48A1 solute carrier family 48 member 1 2 2
MIRT492404 SDK1 sidekick cell adhesion molecule 1 2 2
MIRT492767 PDGFB platelet derived growth factor subunit B 2 2
MIRT492966 NCS1 neuronal calcium sensor 1 2 2
MIRT493295 LLGL2 LLGL2, scribble cell polarity complex component 2 2
MIRT493650 HDLBP high density lipoprotein binding protein 2 2
MIRT493913 FAM127B retrotransposon Gag like 8A 2 4
MIRT495601 NKX2-5 NK2 homeobox 5 2 2
MIRT496875 AHCYL2 adenosylhomocysteinase like 2 2 2
MIRT498514 MYH14 myosin heavy chain 14 2 2
MIRT499178 RBPJL recombination signal binding protein for immunoglobulin kappa J region like 2 2
MIRT502143 KIF5B kinesin family member 5B 2 8
MIRT502692 CSNK1G1 casein kinase 1 gamma 1 2 4
MIRT508460 HOXB6 homeobox B6 2 4
MIRT510430 ZNF207 zinc finger protein 207 2 6
MIRT511837 GPATCH8 G-patch domain containing 8 2 4
MIRT512368 CPM carboxypeptidase M 2 2
MIRT512506 BTBD19 BTB domain containing 19 2 2
MIRT513065 ANKRD45 ankyrin repeat domain 45 2 2
MIRT513267 SCUBE1 signal peptide, CUB domain and EGF like domain containing 1 2 4
MIRT513575 EVX1 even-skipped homeobox 1 2 2
MIRT515051 EBNA1BP2 EBNA1 binding protein 2 2 2
MIRT515790 COL4A3BP collagen type IV alpha 3 binding protein 2 2
MIRT521657 PRKD3 protein kinase D3 2 2
MIRT522679 LUZP1 leucine zipper protein 1 2 6
MIRT528845 RAB32 RAB32, member RAS oncogene family 2 2
MIRT533569 TOR1AIP1 torsin 1A interacting protein 1 2 2
MIRT543738 DHCR7 7-dehydrocholesterol reductase 2 2
MIRT544295 TSPYL1 TSPY like 1 2 2
MIRT544857 MYH2 myosin heavy chain 2 2 4
MIRT557323 HIATL1 major facilitator superfamily domain containing 14B 2 4
MIRT560522 TMEM98 transmembrane protein 98 2 2
MIRT561565 SLC6A9 solute carrier family 6 member 9 2 2
MIRT562374 ERI2 ERI1 exoribonuclease family member 2 2 2
MIRT565780 SEMA6D semaphorin 6D 2 2
MIRT569548 UNC119B unc-119 lipid binding chaperone B 2 2
MIRT569944 PRRT2 proline rich transmembrane protein 2 2 2
MIRT570016 COL1A2 collagen type I alpha 2 chain 2 2
MIRT572163 CRK CRK proto-oncogene, adaptor protein 2 2
MIRT572322 HSPB6 heat shock protein family B (small) member 6 2 2
MIRT573495 IQSEC3 IQ motif and Sec7 domain 3 2 2
MIRT574139 MARVELD1 MARVEL domain containing 1 2 2
MIRT609449 CCDC149 coiled-coil domain containing 149 2 2
MIRT610619 ARHGAP18 Rho GTPase activating protein 18 2 2
MIRT623355 LZIC leucine zipper and CTNNBIP1 domain containing 2 2
MIRT629854 ACOX1 acyl-CoA oxidase 1 2 2
MIRT630516 CDC73 cell division cycle 73 2 2
MIRT632535 PSMB2 proteasome subunit beta 2 2 2
MIRT633975 SLC35E2 solute carrier family 35 member E2 2 2
MIRT636408 MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase 2 2
MIRT641722 LTBR lymphotoxin beta receptor 2 2
MIRT642661 RGS6 regulator of G protein signaling 6 2 2
MIRT649649 MAST3 microtubule associated serine/threonine kinase 3 2 2
MIRT650367 MOCS3 molybdenum cofactor synthesis 3 2 2
MIRT651355 ZBTB40 zinc finger and BTB domain containing 40 2 2
MIRT664840 HUS1 HUS1 checkpoint clamp component 2 2
MIRT667322 MYH9 myosin heavy chain 9 2 2
MIRT670680 SUGT1 SGT1 homolog, MIS12 kinetochore complex assembly cochaperone 2 2
MIRT674922 TRPM6 transient receptor potential cation channel subfamily M member 6 2 2
MIRT675919 CYP51A1 cytochrome P450 family 51 subfamily A member 1 2 2
MIRT676493 GJD3 gap junction protein delta 3 2 2
MIRT680162 ZDHHC20 zinc finger DHHC-type containing 20 2 2
MIRT688008 GSN gelsolin 2 2
MIRT688997 ATP6AP1 ATPase H+ transporting accessory protein 1 2 2
MIRT700337 RAB4A RAB4A, member RAS oncogene family 2 2
MIRT701344 NR4A3 nuclear receptor subfamily 4 group A member 3 2 2
MIRT703519 FKBP15 FK506 binding protein 15 2 2
MIRT703901 EPT1 selenoprotein I 2 2
MIRT705565 ARHGEF18 Rho/Rac guanine nucleotide exchange factor 18 2 2
MIRT709709 DNAJC11 DnaJ heat shock protein family (Hsp40) member C11 2 2
MIRT713108 TMBIM4 transmembrane BAX inhibitor motif containing 4 2 2
MIRT718426 ZNF85 zinc finger protein 85 2 2
MIRT719236 CYSLTR2 cysteinyl leukotriene receptor 2 2 2
MIRT719326 STAC SH3 and cysteine rich domain 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-4747 Paclitaxel 36314 NSC125973 approved resistant cell line (A2780)
hsa-miR-4747-5p Temozolomide 5394 NSC362856 approved sensitive cell line (U251)
hsa-miR-4747-5p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-4747-5p Gemcitabine 60750 NSC613327 approved sensitive cell line (PANC-1) (1500 ng/ml)

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