miRTarBase - #MIRT457396


—
pre-miRNA Information
pre-miRNA hsa-mir-4534   
Genomic Coordinates chr22: 37988794 - 37988853
Description Homo sapiens miR-4534 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-4534
Sequence 36| GGAUGGAGGAGGGGUCU |52
Evidence Experimental
Experiments Illumina
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs890798116 2 dbSNP
rs1382774432 11 dbSNP
rs982883970 15 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol CAMK2A   
Synonyms CAMKA
Description calcium/calmodulin dependent protein kinase II alpha
Transcript NM_015981   
Other Transcripts NM_171825   
Expression
Putative miRNA Targets on CAMK2A
3'UTR of CAMK2A
(miRNA target sites are highlighted)		 
>CAMK2A|NM_015981|3'UTR
   1 GGGACCAGGCTGGGGTCGCTGCGTTGCTGTGCCGCAGAGATCCACTCTGTCCGTGGAGTGGAGCTGCTGGTTCTCCCAGG
  81 TGGATTTTGCTGGAATTCTCCCATGTCATCACCCCACCACCGTCACTTCTGTACCTGCATCAAGAAAACCTGCTTGTTCA
 161 CAAAAGTCATCGCAACTTCAGAGCGAACGGCCACATCTCCCCACCTCTCACCCCCACCCTCTCCCCTGCCAGGCTGGGGC
 241 TTCCTCAGGCATGGGTGTCCACAGCACTGGCCCCCTCTCCCCAGCCTCAGCTGCTGTCCGCCTGATCTGTCTTGGGCTGT
 321 AGGCTAGAATGCCCGGGCTGGTGCCCACCAGGGGCTGGGGAGAAGGAGGGGTGGCATGATGAGGAAGGCAGCATCCGTCC
 401 GTCCCTCTCCCAGACCTCTCCTCTTCCAGTGTCCCCGGGGAAGGGCAGATGACACTCCCTTCCCCCTAAGCCAACCGCAC
 481 TGAAGGAGTGGGGAGAAGAGCATACGCCAGGAGCCTCCTGCCTCAAAGTGCTCCCCTAAGTCTTCTTCCTCCTGTGCTGA
 561 CCTCAGGGTGGTCTGACCCTTCCCTCGGTGTGGGGGATGTGGCCCTCTCAGGTGCCCCTACTTGCTTTCTGCTTCCTTCT
 641 GGTGAAGTCCACCTCCAACATTAACCTGCCCACCCCACCCCCGTCATCCCTGGAGAATTCCAGCTTTGTCGTATCTCAGA
 721 GAGGGAATCTAATTGTTTTTGGGGGGCAAAAGAAAGCAACGTTTAGGTATCACTTCTACTTGGACCGCATGCCTTTTTAT
 801 AGCCAAATTTCTGTGTATTTCGTAAATGGATTTCGCGTTAATGGATATTTATGTAATAACTAGACTTCTCAGATTATTGT
 881 GAGAAGGGTCAGGTTGGAAGGGGTGTAGGAAGAGGGGTGAGGGGTAGTTTTTTTCTGTTCTAGTTTTTTTTTTTTTTTTT
 961 GTCATCTCTGAGGTGGACCTTGTCACCTGTGGTTATTGGGGCCAAGGTGGACTCAGCTCCGGGGAGAAGGGCCTCTCTGC
1041 CATTTCGGTCCCAAGGTGAGCTGACACAGGCGTTCCTTTTGGGACTGTGGAAGCATCAGATGCCAGCACTGACTCAGGAA
1121 CAGCAAGTCAGGGCAGAGAGGAGGAGGGAGGCTGTCAGGATGGAAATACCTGGACTTTTCTTTGCTTCCCTCGCAAACTG
1201 GGGTCTTCTCTACCGAACTTCCCAGGATTTCATCTCACCATATCTGTGTGCCGCCCCCAGCACCCCCCACCCACCTCTGG
1281 GGGGCCCGTGAGCGTGTGTCTTCATTGCCTCTCTCCCCTTGGCGTCTGATGACCACAGCAAAGCACTGGGAATTTCTACT
1361 CTTCATGCCTCATCCTGCAGCCTCGGGTTCGCATTCTCTCTTTCTTTTCCTCTTTCCCTCTTTCCCTGGGATTGACTCTG
1441 AGTGGAATACCTTGGCACATCCACTAGGATCTACTGTCTGCACTGTTTTCTTTGCATGACTTTATACGCAGTAAGTATGT
1521 TGAAAACAAACAAAAAGAAGAAAACACTCAACAAAACCAATCTACATGTTTTGGACTAAAAAAAAAAATAGAGGTTGTAT
1601 TCTCAGTGTCCGACTCGGAATTATGTTGCTGCCTCTCTGTGCTTTTGGCCTCTGTGTGGCCGTGTTTTGCCAGCATGAGA
1681 TACTGTCCCCTCTGGAGGATTTTAGGGGAGGAAGAGCCACGTCCCCAGGGATTGGAGGAGGCTCCGGTACCCTCGACCCT
1761 CCTGGGTGTTGGTTGGAGCAGAACTGGTGAGGATGTTTGATCCGAGATTTTCTGAGCTCTCCCCAATCACCAGCTGTCTG
1841 CTGGGTTCTTTTCTCAAGTCCTGCTGCCCAGGCCCAGGTGAGACAGGCAACGCCAGGTCTGCAGGCCAGGAGAGATGCTG
1921 CCCAGGCCTCCTGGTTTCCAAGCTGGTCCATCACTGGCCTCTGTCCTTGGCAGAGACCTTGCTGCCCAGGCCCAGGGGCA
2001 GGCTCTTGGCCTGCCCCAGGCCCAGAGGGCTTCCCAGTAAGGCCCAGTGATCCCATTATCCCAGGGGCAAAACCACCTGT
2081 CCCCTTTTGAGCTGCCAGTTCCCTACAGCCATCCCCAGTCAAGGGTGAGGGTGTGGCCTTCACCAGGGGCTGCTGTAATT
2161 ACCGAGCAAGGTCTGAGCTCTTCTTCAGCCTCAGTTCCCTCATTGGTTAAAAGGGTTCTTTGTTCCCATCCAGCCGATGA
2241 AGGAGCAAACGTCTGGCTATGTGAAGCCTAATTTACCTGCAGGAACTGGCAGGGATAGTCACTGGCTGGACTCCTGTTTA
2321 CTTCTAGACCTGGTCAGGCTCCATCCCCTCCCCCACCTGCCCCTGATTCCCCTCGTCGGTGCCTGTCAACTGCTTTTCAG
2401 CAGTGGACTGCAGGGGAAAGAGCAGTGATTTGGGGTGAGTAGGCTTCAATTCCCAGCTCTGACCAGACTTGCTGTGTGAC
2481 CTTGGGCAAGTTCCTTTCCCTCTTTGGAGCTTGGTTTCCCTGCCAGAGGAAACTGAGCTGGAGGAGCCTGAGGTCCTGCC
2561 TTTCATTGGCTGACACACCTCCTGTCCACTGTGTCACTCTCCAAGTGCCAGAGAAGTGGAGGCAGATCGCTACCCCAGGC
2641 TGAGATGGCCCCCACTGTGAAGGCCACGCCTGTGGGTGGGCAGCCACCTGGTGCCACCACAGGGCACCAGGGATGATCCT
2721 GATGTGGCAGGCAGGGGAGACTCACAGAAAAATCTGCCCAGAGCCTACCCTCACCAGACAAACTCTGTGCTCCTCCAAAA
2801 CATCCTTTAGATGCAAAATAATAATAATAATAATAATAAATAAATAAATAAAAATCCAAACCCAAGTCAAAACCTTGGCT
2881 CCAGCATGAAAACACGTTTACAGGAAAGTGTTCTCCTGGGTTTGTGCCCACCATGGTGCGAATCCTGACCCAAGGCCTCC
2961 TGTCTCCCTTCAAAGGGAGACCCTTTTGGGGGATGAGTTTGCCAGACTCCCCGTGCTGGTTTCTTTGTTACTATTTGTTT
3041 GGGGTTTTGTTTTAGTTCTTTTTTTTTTTCTTTTCTTTTTTAAAAATATGTGGCTGTGAACTTGAATGAACACTGCTCAA
3121 ACTTTCTGCTATTGGGGGGGGCGGGTGGGATGGGAAGAAGGGGCGTTTGTTTTATTCTTGGTGTTTTCAGTGCAATAAAT
3201 AGCTACAAACTTCTGTGCAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' ucUGGG-GAG---GAGGUAGg 5'
            |||:  ||   ||||||| 
Target 5' agACCTGGTCAGGCTCCATCc 3'
 2326 - 2346 143.00 -18.30
2 
miRNA  3' ucUGGGGA---GGAGGUAGg 5'
            ||::||   ||| |||| 
Target 5' tcACTTCTGTACCTGCATCa 3'
 123 - 142 123.00 -13.30
3 
miRNA  3' ucUGGGGAGGAGGUAGg 5'
            | :|| |||||| | 
Target 5' gaAGTCCACCTCCAACa 3'
 644 - 660 123.00 -14.00
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN4844357 2 COSMIC
COSN14149079 17 COSMIC
COSN31531573 18 COSMIC
COSN507385 22 COSMIC
COSN30169986 25 COSMIC
COSN26969073 31 COSMIC
COSN14149078 33 COSMIC
COSN30138268 34 COSMIC
COSN30519096 40 COSMIC
COSN30484633 42 COSMIC
COSN30185282 47 COSMIC
COSN30453758 87 COSMIC
COSN26730535 118 COSMIC
COSN31966683 121 COSMIC
COSN25844124 149 COSMIC
COSN30129648 184 COSMIC
COSN30636428 188 COSMIC
COSN29858176 284 COSMIC
COSN20102057 340 COSMIC
COSN31590394 391 COSMIC
COSN26222600 397 COSMIC
COSN28754951 447 COSMIC
COSN26111118 514 COSMIC
COSN29285543 587 COSMIC
COSN29557422 623 COSMIC
COSN26221836 708 COSMIC
COSN15154240 835 COSMIC
COSN14759745 1008 COSMIC
COSN7880304 1042 COSMIC
COSN32058762 1294 COSMIC
COSN5592026 1324 COSMIC
COSN9411364 1354 COSMIC
COSN24301347 1442 COSMIC
COSN31609459 1490 COSMIC
COSN26585236 1509 COSMIC
COSN28928709 1577 COSMIC
COSN23036977 1578 COSMIC
COSN14902160 1754 COSMIC
COSN23303701 1891 COSMIC
COSN31778454 1985 COSMIC
COSN2523440 2054 COSMIC
COSN31485175 2642 COSMIC
COSN31535823 2763 COSMIC
COSN20102054 2817 COSMIC
COSN2076520 2819 COSMIC
COSN20102056 2825 COSMIC
COSN27621928 2835 COSMIC
COSN7880303 2862 COSMIC
COSN31611078 3056 COSMIC
COSN20102048 3058 COSMIC
COSN26574366 3062 COSMIC
COSN28706659 3135 COSMIC
COSN20102045 3141 COSMIC
COSN20102046 3142 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1403916472 4 dbSNP
rs1363283126 8 dbSNP
rs768232346 11 dbSNP
rs1424674038 12 dbSNP
rs1407257379 15 dbSNP
rs563702310 17 dbSNP
rs545697976 18 dbSNP
rs779026434 21 dbSNP
rs201811573 22 dbSNP
rs374575000 23 dbSNP
rs369901307 29 dbSNP
rs755226405 33 dbSNP
rs751816059 34 dbSNP
rs150250733 35 dbSNP
rs750283642 36 dbSNP
rs756921569 36 dbSNP
rs1351212017 38 dbSNP
rs372475680 44 dbSNP
rs1040789311 47 dbSNP
rs1289403840 50 dbSNP
rs140679603 51 dbSNP
rs61217791 51 dbSNP
rs75000324 52 dbSNP
rs1379065623 53 dbSNP
rs1256924780 56 dbSNP
rs1343264075 67 dbSNP
rs765780167 69 dbSNP
rs1413546674 72 dbSNP
rs762275291 73 dbSNP
rs776071504 76 dbSNP
rs1316182943 77 dbSNP
rs573824652 78 dbSNP
rs1408562607 82 dbSNP
rs760046210 83 dbSNP
rs1404345683 103 dbSNP
rs1479295239 105 dbSNP
rs1321215887 106 dbSNP
rs1427543725 108 dbSNP
rs775220318 112 dbSNP
rs934577057 115 dbSNP
rs141071420 118 dbSNP
rs745686978 121 dbSNP
rs1216442618 122 dbSNP
rs761561805 122 dbSNP
rs1342086528 123 dbSNP
rs1449251355 124 dbSNP
rs1269252049 129 dbSNP
rs774254394 132 dbSNP
rs771037753 135 dbSNP
rs1284860432 136 dbSNP
rs1448919991 141 dbSNP
rs151118217 144 dbSNP
rs1414017132 148 dbSNP
rs1360792220 149 dbSNP
rs1267922296 152 dbSNP
rs777509465 154 dbSNP
rs765564257 157 dbSNP
rs1335994859 164 dbSNP
rs1468088603 166 dbSNP
rs1408002245 168 dbSNP
rs921311443 169 dbSNP
rs115797668 170 dbSNP
rs758589408 171 dbSNP
rs965877449 172 dbSNP
rs551245232 184 dbSNP
rs562834086 189 dbSNP
rs1452740087 200 dbSNP
rs565830737 204 dbSNP
rs1183198250 205 dbSNP
rs983208819 207 dbSNP
rs754367641 211 dbSNP
rs908065379 212 dbSNP
rs952940418 214 dbSNP
rs546627283 215 dbSNP
rs528452188 218 dbSNP
rs1169268774 219 dbSNP
rs1397529196 221 dbSNP
rs1411553063 228 dbSNP
rs1329505260 230 dbSNP
rs1384684753 232 dbSNP
rs960130874 237 dbSNP
rs1295345569 253 dbSNP
rs1356265162 255 dbSNP
rs987656140 258 dbSNP
rs1256188016 265 dbSNP
rs1002293808 270 dbSNP
rs1196859934 274 dbSNP
rs980105891 283 dbSNP
rs905371320 296 dbSNP
rs1025136887 299 dbSNP
rs780881398 300 dbSNP
rs868450966 304 dbSNP
rs1262925805 305 dbSNP
rs112896997 306 dbSNP
rs1463113979 318 dbSNP
rs760749643 319 dbSNP
rs549087104 334 dbSNP
rs1013675432 335 dbSNP
rs904409113 337 dbSNP
rs530874070 338 dbSNP
rs33920720 340 dbSNP
rs5872172 341 dbSNP
rs374563226 342 dbSNP
rs1334665209 346 dbSNP
rs1375864014 348 dbSNP
rs1399592194 354 dbSNP
rs1381598202 355 dbSNP
rs563916786 358 dbSNP
rs1228327306 368 dbSNP
rs932595865 370 dbSNP
rs1343415219 374 dbSNP
rs921092324 375 dbSNP
rs1290484664 383 dbSNP
rs2217641 384 dbSNP
rs545225283 396 dbSNP
rs1488145637 397 dbSNP
rs1215473706 399 dbSNP
rs1049346561 400 dbSNP
rs370722785 401 dbSNP
rs908636188 406 dbSNP
rs982772977 409 dbSNP
rs1446451640 411 dbSNP
rs184203395 415 dbSNP
rs1193083495 421 dbSNP
rs1027153420 423 dbSNP
rs1037944769 424 dbSNP
rs1427326823 427 dbSNP
rs1264262106 428 dbSNP
rs980985825 431 dbSNP
rs1490293985 436 dbSNP
rs767757040 437 dbSNP
rs1323034007 440 dbSNP
rs957710 445 dbSNP
rs1025123515 446 dbSNP
rs957709 447 dbSNP
rs959788865 450 dbSNP
rs938713594 459 dbSNP
rs1238344940 473 dbSNP
rs1262859260 474 dbSNP
rs1031847918 476 dbSNP
rs376905162 477 dbSNP
rs1266098956 478 dbSNP
rs1449330784 482 dbSNP
rs1195442296 486 dbSNP
rs555375816 488 dbSNP
rs947401081 493 dbSNP
rs543560329 501 dbSNP
rs749177493 502 dbSNP
rs374631793 505 dbSNP
rs576005520 506 dbSNP
rs145916509 513 dbSNP
rs1388697584 514 dbSNP
rs1443119986 515 dbSNP
rs1040858047 517 dbSNP
rs1364766942 521 dbSNP
rs1327169201 526 dbSNP
rs140231558 533 dbSNP
rs908589603 537 dbSNP
rs986601174 549 dbSNP
rs539900482 551 dbSNP
rs1028024028 562 dbSNP
rs995248584 566 dbSNP
rs931435764 569 dbSNP
rs919919044 570 dbSNP
rs1480273768 573 dbSNP
rs572607568 577 dbSNP
rs1175382840 584 dbSNP
rs969589578 586 dbSNP
rs1015693910 587 dbSNP
rs918178138 596 dbSNP
rs992306351 598 dbSNP
rs1165820397 602 dbSNP
rs1399611252 610 dbSNP
rs1464554394 615 dbSNP
rs1300371811 616 dbSNP
rs1057280490 620 dbSNP
rs554114532 624 dbSNP
rs1289936149 625 dbSNP
rs1194785253 632 dbSNP
rs1395746284 633 dbSNP
rs1311027463 636 dbSNP
rs1336907294 646 dbSNP
rs553628592 658 dbSNP
rs957097240 659 dbSNP
rs1344624171 663 dbSNP
rs1281215861 668 dbSNP
rs1316705851 669 dbSNP
rs1438837038 674 dbSNP
rs1331946030 676 dbSNP
rs906064176 680 dbSNP
rs1031210404 682 dbSNP
rs780619214 683 dbSNP
rs947480273 689 dbSNP
rs1255118243 698 dbSNP
rs7448702 701 dbSNP
rs373456869 704 dbSNP
rs371373892 706 dbSNP
rs548923924 709 dbSNP
rs996530476 710 dbSNP
rs531039633 711 dbSNP
rs1465971763 712 dbSNP
rs986716218 723 dbSNP
rs1377623397 727 dbSNP
rs1416281205 732 dbSNP
rs953869475 732 dbSNP
rs1478794428 748 dbSNP
rs1028136837 755 dbSNP
rs1041365624 756 dbSNP
rs1246879451 757 dbSNP
rs973826169 757 dbSNP
rs1008021078 760 dbSNP
rs570050508 761 dbSNP
rs1046925690 762 dbSNP
rs1486505597 767 dbSNP
rs1211889837 769 dbSNP
rs1180685974 772 dbSNP
rs931383554 777 dbSNP
rs1484934599 780 dbSNP
rs1064129 785 dbSNP
rs920029235 803 dbSNP
rs1420292545 817 dbSNP
rs1433160226 819 dbSNP
rs551991956 821 dbSNP
rs752734160 822 dbSNP
rs948065639 827 dbSNP
rs1015227062 834 dbSNP
rs79354200 835 dbSNP
rs746674731 836 dbSNP
rs560119760 837 dbSNP
rs896191464 846 dbSNP
rs1035935771 851 dbSNP
rs1003155463 856 dbSNP
rs1349798551 868 dbSNP
rs1234661754 887 dbSNP
rs924093830 891 dbSNP
rs1285035275 893 dbSNP
rs1315407804 897 dbSNP
rs979617648 900 dbSNP
rs1345488107 903 dbSNP
rs968431004 905 dbSNP
rs541770238 915 dbSNP
rs1255370214 917 dbSNP
rs1455081215 922 dbSNP
rs906010316 925 dbSNP
rs1279111945 926 dbSNP
rs1044600359 928 dbSNP
rs1440303280 937 dbSNP
rs1379195032 940 dbSNP
rs1021396513 941 dbSNP
rs1452512984 942 dbSNP
rs1404602124 943 dbSNP
rs947464739 944 dbSNP
rs1439443094 951 dbSNP
rs1323807257 959 dbSNP
rs1415362144 960 dbSNP
rs1285150789 961 dbSNP
rs1323785292 961 dbSNP
rs1441522073 961 dbSNP
rs201670618 961 dbSNP
rs35164363 961 dbSNP
rs537846929 961 dbSNP
rs747281210 962 dbSNP
rs1275112336 963 dbSNP
rs1469343404 964 dbSNP
rs1178533529 971 dbSNP
rs529578992 996 dbSNP
rs1471332697 1002 dbSNP
rs1157618748 1006 dbSNP
rs7732895 1008 dbSNP
rs192111888 1009 dbSNP
rs1178766808 1017 dbSNP
rs934652163 1019 dbSNP
rs1328046078 1020 dbSNP
rs1333784775 1021 dbSNP
rs1019315196 1022 dbSNP
rs912594062 1024 dbSNP
rs1241151621 1025 dbSNP
rs1378792995 1037 dbSNP
rs1008553682 1045 dbSNP
rs1442725291 1046 dbSNP
rs921068665 1047 dbSNP
rs887059905 1053 dbSNP
rs143235845 1062 dbSNP
rs570833066 1071 dbSNP
rs187749277 1072 dbSNP
rs1205740252 1076 dbSNP
rs982586830 1083 dbSNP
rs898551980 1087 dbSNP
rs1045129799 1102 dbSNP
rs1245277909 1104 dbSNP
rs948203213 1127 dbSNP
rs960347278 1134 dbSNP
rs896472636 1136 dbSNP
rs1056500019 1142 dbSNP
rs1167268544 1148 dbSNP
rs1305040834 1149 dbSNP
rs546006206 1156 dbSNP
rs1344968609 1158 dbSNP
rs1374592822 1161 dbSNP
rs755350646 1162 dbSNP
rs970309304 1169 dbSNP
rs1417456029 1173 dbSNP
rs1023104098 1176 dbSNP
rs1012157430 1182 dbSNP
rs1268486042 1183 dbSNP
rs1342152423 1184 dbSNP
rs1215640803 1185 dbSNP
rs979565143 1191 dbSNP
rs946874282 1192 dbSNP
rs539753446 1193 dbSNP
rs1259102588 1194 dbSNP
rs914283239 1199 dbSNP
rs1411006319 1204 dbSNP
rs975156384 1209 dbSNP
rs963861589 1214 dbSNP
rs1370819564 1215 dbSNP
rs1473125737 1216 dbSNP
rs184845639 1217 dbSNP
rs1168385933 1218 dbSNP
rs1213447466 1221 dbSNP
rs35651593 1246 dbSNP
rs1432567801 1252 dbSNP
rs986505783 1253 dbSNP
rs868665173 1256 dbSNP
rs1222030939 1257 dbSNP
rs1357299636 1266 dbSNP
rs1315018054 1268 dbSNP
rs34429496 1269 dbSNP
rs1432143117 1272 dbSNP
rs1229362239 1285 dbSNP
rs921184829 1287 dbSNP
rs1237048951 1288 dbSNP
rs1281479321 1290 dbSNP
rs1268954544 1291 dbSNP
rs1204157529 1292 dbSNP
rs1402189917 1293 dbSNP
rs951346239 1294 dbSNP
rs941182636 1297 dbSNP
rs1025524841 1303 dbSNP
rs908399063 1306 dbSNP
rs556864595 1323 dbSNP
rs567968447 1324 dbSNP
rs11952641 1326 dbSNP
rs191193183 1328 dbSNP
rs1156999478 1334 dbSNP
rs78265902 1335 dbSNP
rs927583123 1346 dbSNP
rs1325299951 1348 dbSNP
rs34864007 1351 dbSNP
rs1369504416 1359 dbSNP
rs1012735478 1364 dbSNP
rs570166639 1365 dbSNP
rs1405862838 1368 dbSNP
rs1418647746 1372 dbSNP
rs746199208 1384 dbSNP
rs1258521375 1390 dbSNP
rs59633008 1391 dbSNP
rs1208877557 1394 dbSNP
rs957755004 1399 dbSNP
rs1031859602 1402 dbSNP
rs1195389325 1402 dbSNP
rs1253421678 1404 dbSNP
rs902732116 1404 dbSNP
rs1418232805 1408 dbSNP
rs1179938749 1416 dbSNP
rs113163901 1418 dbSNP
rs1454491970 1420 dbSNP
rs1198951614 1422 dbSNP
rs756627754 1427 dbSNP
rs922085953 1434 dbSNP
rs1327105707 1437 dbSNP
rs1222333562 1445 dbSNP
rs1307022900 1451 dbSNP
rs1389963710 1458 dbSNP
rs974967296 1464 dbSNP
rs1309599048 1466 dbSNP
rs1337216908 1468 dbSNP
rs187757305 1474 dbSNP
rs1228594929 1477 dbSNP
rs767643124 1480 dbSNP
rs547971932 1507 dbSNP
rs750484768 1508 dbSNP
rs1215504183 1515 dbSNP
rs1265889817 1518 dbSNP
rs529658277 1531 dbSNP
rs562357916 1535 dbSNP
rs899877229 1535 dbSNP
rs1341502342 1539 dbSNP
rs1473064676 1539 dbSNP
rs1187446504 1543 dbSNP
rs951083330 1548 dbSNP
rs1283115162 1551 dbSNP
rs941310863 1551 dbSNP
rs766939686 1557 dbSNP
rs762027741 1558 dbSNP
rs1373077804 1560 dbSNP
rs918292907 1561 dbSNP
rs1300314131 1563 dbSNP
rs973955042 1565 dbSNP
rs962632266 1567 dbSNP
rs927699265 1582 dbSNP
rs1294953514 1584 dbSNP
rs1306896981 1589 dbSNP
rs1365851554 1589 dbSNP
rs78529899 1589 dbSNP
rs879574605 1589 dbSNP
rs1436528510 1593 dbSNP
rs1225116242 1596 dbSNP
rs1252888059 1608 dbSNP
rs1023408608 1611 dbSNP
rs1012102388 1612 dbSNP
rs1255587163 1616 dbSNP
rs767524503 1617 dbSNP
rs1182576945 1627 dbSNP
rs1418861559 1628 dbSNP
rs990787038 1631 dbSNP
rs1173111777 1636 dbSNP
rs1374012992 1639 dbSNP
rs1035116128 1660 dbSNP
rs549779315 1661 dbSNP
rs1172162347 1662 dbSNP
rs1373305977 1676 dbSNP
rs112597831 1683 dbSNP
rs1360613954 1685 dbSNP
rs1380482832 1690 dbSNP
rs957658231 1704 dbSNP
rs1032223197 1709 dbSNP
rs1233375878 1720 dbSNP
rs182629016 1721 dbSNP
rs902511707 1723 dbSNP
rs72837583 1728 dbSNP
rs1011149700 1731 dbSNP
rs1431250582 1735 dbSNP
rs1241624172 1737 dbSNP
rs900779154 1745 dbSNP
rs1269686517 1746 dbSNP
rs1249267411 1747 dbSNP
rs1191995225 1752 dbSNP
rs34266615 1754 dbSNP
rs1236491746 1755 dbSNP
rs749346291 1758 dbSNP
rs1397237179 1766 dbSNP
rs1201064981 1768 dbSNP
rs1415853194 1773 dbSNP
rs1176275666 1777 dbSNP
rs1344107976 1779 dbSNP
rs1029693473 1781 dbSNP
rs944901910 1783 dbSNP
rs1262888106 1785 dbSNP
rs149933620 1789 dbSNP
rs912259502 1791 dbSNP
rs571766100 1803 dbSNP
rs79207651 1804 dbSNP
rs929763148 1813 dbSNP
rs541622938 1824 dbSNP
rs6869490 1825 dbSNP
rs370847074 1827 dbSNP
rs1268832061 1837 dbSNP
rs556024193 1841 dbSNP
rs1371967442 1844 dbSNP
rs1192261431 1866 dbSNP
rs191256988 1868 dbSNP
rs939163112 1870 dbSNP
rs1478528510 1872 dbSNP
rs1191419651 1880 dbSNP
rs906395380 1887 dbSNP
rs1400878716 1888 dbSNP
rs1336035302 1891 dbSNP
rs746245033 1892 dbSNP
rs1460881142 1908 dbSNP
rs947806324 1909 dbSNP
rs1177034993 1910 dbSNP
rs914866203 1913 dbSNP
rs1371517706 1923 dbSNP
rs576384293 1927 dbSNP
rs769836752 1929 dbSNP
rs558100344 1938 dbSNP
rs1212383053 1946 dbSNP
rs759435022 1951 dbSNP
rs1180646554 1953 dbSNP
rs960571695 1954 dbSNP
rs1231508857 1957 dbSNP
rs1035302847 1958 dbSNP
rs539560967 1959 dbSNP
rs1183840378 1963 dbSNP
rs1412090455 1968 dbSNP
rs1243033449 1969 dbSNP
rs1474559607 1970 dbSNP
rs1162705441 1985 dbSNP
rs1415949077 1988 dbSNP
rs1405863088 1991 dbSNP
rs1327984517 1994 dbSNP
rs750759815 1996 dbSNP
rs924886614 1996 dbSNP
rs977678343 1998 dbSNP
rs999607514 1999 dbSNP
rs966812209 2002 dbSNP
rs1484408934 2005 dbSNP
rs1231604189 2006 dbSNP
rs1257013939 2014 dbSNP
rs1022286252 2015 dbSNP
rs950978014 2017 dbSNP
rs34655241 2018 dbSNP
rs1010930482 2021 dbSNP
rs1271362912 2026 dbSNP
rs548589134 2026 dbSNP
rs900721900 2028 dbSNP
rs964171474 2029 dbSNP
rs1017312269 2036 dbSNP
rs187985136 2043 dbSNP
rs1005552244 2045 dbSNP
rs1039291172 2048 dbSNP
rs1314216392 2060 dbSNP
rs1417146496 2066 dbSNP
rs548048677 2074 dbSNP
rs1375127965 2075 dbSNP
rs890622182 2078 dbSNP
rs906343663 2081 dbSNP
rs1341099387 2083 dbSNP
rs536039480 2101 dbSNP
rs1430665915 2105 dbSNP
rs183021002 2106 dbSNP
rs1044934713 2111 dbSNP
rs547199963 2116 dbSNP
rs893559542 2120 dbSNP
rs531997567 2124 dbSNP
rs918356656 2127 dbSNP
rs1037974565 2130 dbSNP
rs941036595 2131 dbSNP
rs1192389861 2145 dbSNP
rs916442288 2158 dbSNP
rs530134149 2163 dbSNP
rs770372502 2164 dbSNP
rs1433127314 2166 dbSNP
rs939297868 2170 dbSNP
rs563933970 2173 dbSNP
rs1053986011 2177 dbSNP
rs1316304081 2190 dbSNP
rs935006004 2193 dbSNP
rs1426146574 2196 dbSNP
rs10038918 2197 dbSNP
rs1041932568 2205 dbSNP
rs1487529508 2209 dbSNP
rs1369173775 2213 dbSNP
rs1283357919 2222 dbSNP
rs1257329260 2226 dbSNP
rs1343705644 2229 dbSNP
rs1218356373 2235 dbSNP
rs1204101162 2240 dbSNP
rs1265670484 2241 dbSNP
rs1466228058 2243 dbSNP
rs1353779902 2245 dbSNP
rs190785277 2250 dbSNP
rs1252167451 2251 dbSNP
rs1452277399 2256 dbSNP
rs922744199 2258 dbSNP
rs975557952 2259 dbSNP
rs1242475379 2261 dbSNP
rs1156942477 2263 dbSNP
rs1342242397 2267 dbSNP
rs777408020 2268 dbSNP
rs964434968 2290 dbSNP
rs1313379028 2293 dbSNP
rs1381404818 2297 dbSNP
rs139169139 2306 dbSNP
rs987002884 2310 dbSNP
rs559808389 2311 dbSNP
rs186399006 2313 dbSNP
rs951395995 2324 dbSNP
rs1331380015 2325 dbSNP
rs1025670985 2329 dbSNP
rs1285945392 2335 dbSNP
rs1330540568 2336 dbSNP
rs1228939734 2338 dbSNP
rs1272399298 2343 dbSNP
rs574271571 2354 dbSNP
rs1437497108 2358 dbSNP
rs964705048 2360 dbSNP
rs1179863088 2362 dbSNP
rs1414296543 2365 dbSNP
rs1472923248 2365 dbSNP
rs1018057349 2369 dbSNP
rs1416417932 2374 dbSNP
rs1420605565 2375 dbSNP
rs562677803 2377 dbSNP
rs1023434211 2402 dbSNP
rs1305730538 2410 dbSNP
rs890728065 2414 dbSNP
rs544197979 2416 dbSNP
rs111466577 2419 dbSNP
rs73796375 2432 dbSNP
rs1319904511 2433 dbSNP
rs550889299 2434 dbSNP
rs1246851135 2444 dbSNP
rs1265836537 2448 dbSNP
rs569049701 2452 dbSNP
rs1203289348 2468 dbSNP
rs182017467 2471 dbSNP
rs1477012357 2474 dbSNP
rs896873725 2476 dbSNP
rs1038085779 2486 dbSNP
rs1254135539 2487 dbSNP
rs1265864439 2487 dbSNP
rs1166040881 2492 dbSNP
rs941150924 2495 dbSNP
rs1460722837 2504 dbSNP
rs539809598 2519 dbSNP
rs999705127 2523 dbSNP
rs1372084027 2524 dbSNP
rs894801607 2529 dbSNP
rs1207504966 2546 dbSNP
rs1055225950 2547 dbSNP
rs780436184 2549 dbSNP
rs1376287185 2554 dbSNP
rs1397727707 2559 dbSNP
rs1313257433 2560 dbSNP
rs1325786520 2569 dbSNP
rs1225980928 2584 dbSNP
rs1357888562 2590 dbSNP
rs1051391227 2599 dbSNP
rs927888622 2608 dbSNP
rs934211482 2610 dbSNP
rs1182951646 2618 dbSNP
rs977891496 2628 dbSNP
rs945194938 2629 dbSNP
rs915117216 2630 dbSNP
rs572605070 2635 dbSNP
rs1400804998 2649 dbSNP
rs564690788 2655 dbSNP
rs942873876 2664 dbSNP
rs554283274 2667 dbSNP
rs756959817 2668 dbSNP
rs1467194123 2669 dbSNP
rs1302909920 2670 dbSNP
rs1384231300 2671 dbSNP
rs951559981 2674 dbSNP
rs1365595548 2675 dbSNP
rs987897287 2676 dbSNP
rs1299376816 2678 dbSNP
rs1210983934 2681 dbSNP
rs1314156467 2681 dbSNP
rs116563155 2687 dbSNP
rs1026992594 2719 dbSNP
rs1463964602 2720 dbSNP
rs1167829207 2721 dbSNP
rs2163766 2725 dbSNP
rs1426184887 2726 dbSNP
rs899335720 2727 dbSNP
rs550308584 2728 dbSNP
rs1189837347 2768 dbSNP
rs1422698739 2771 dbSNP
rs757808056 2778 dbSNP
rs1480325417 2779 dbSNP
rs538157761 2787 dbSNP
rs1023550543 2789 dbSNP
rs1455594847 2797 dbSNP
rs571119766 2797 dbSNP
rs1452781421 2801 dbSNP
rs894910603 2807 dbSNP
rs1032606215 2811 dbSNP
rs1054773960 2823 dbSNP
rs1197930825 2825 dbSNP
rs1291558336 2825 dbSNP
rs376082789 2826 dbSNP
rs1491326912 2827 dbSNP
rs939026616 2827 dbSNP
rs1327095509 2828 dbSNP
rs1491340364 2828 dbSNP
rs34777554 2828 dbSNP
rs386405298 2828 dbSNP
rs1259727817 2830 dbSNP
rs1269397510 2830 dbSNP
rs1468418505 2831 dbSNP
rs1219894207 2834 dbSNP
rs1248792350 2836 dbSNP
rs138971440 2837 dbSNP
rs1489277198 2837 dbSNP
rs1218964783 2839 dbSNP
rs1160731925 2840 dbSNP
rs1290280515 2840 dbSNP
rs1410597077 2840 dbSNP
rs1471284514 2840 dbSNP
rs147490193 2840 dbSNP
rs999252583 2840 dbSNP
rs1250696292 2841 dbSNP
rs1344036510 2841 dbSNP
rs1273242262 2844 dbSNP
rs1183774056 2853 dbSNP
rs1235774058 2853 dbSNP
rs57339321 2853 dbSNP
rs902277311 2854 dbSNP
rs1029914636 2855 dbSNP
rs997135196 2868 dbSNP
rs1167713781 2872 dbSNP
rs900210921 2878 dbSNP
rs906416032 2879 dbSNP
rs1431832050 2887 dbSNP
rs1042326567 2891 dbSNP
rs945310260 2895 dbSNP
rs915066221 2896 dbSNP
rs6882623 2899 dbSNP
rs1380521462 2901 dbSNP
rs943444885 2902 dbSNP
rs1214404112 2905 dbSNP
rs1272900997 2908 dbSNP
rs1414200512 2909 dbSNP
rs888593925 2913 dbSNP
rs1206805757 2920 dbSNP
rs1441277003 2924 dbSNP
rs1423528007 2933 dbSNP
rs1049047467 2934 dbSNP
rs1239200244 2935 dbSNP
rs930006208 2936 dbSNP
rs910642382 2939 dbSNP
rs987458261 2940 dbSNP
rs918675238 2945 dbSNP
rs1478844235 2947 dbSNP
rs527278402 2951 dbSNP
rs1377668591 2955 dbSNP
rs1177520745 2956 dbSNP
rs1360295476 2957 dbSNP
rs1434970722 2959 dbSNP
rs866671221 2964 dbSNP
rs982228708 2966 dbSNP
rs1239858354 2968 dbSNP
rs949354329 2973 dbSNP
rs1230177346 2982 dbSNP
rs954874736 2983 dbSNP
rs916609855 2984 dbSNP
rs1198278366 2988 dbSNP
rs1280089991 2990 dbSNP
rs1442970999 2996 dbSNP
rs990727348 2997 dbSNP
rs919296703 3003 dbSNP
rs972278721 3004 dbSNP
rs1188960295 3005 dbSNP
rs963625063 3007 dbSNP
rs1032140083 3009 dbSNP
rs1377339008 3012 dbSNP
rs1016367744 3013 dbSNP
rs1174425128 3019 dbSNP
rs1013519286 3027 dbSNP
rs1202359304 3042 dbSNP
rs1457196363 3042 dbSNP
rs1030029585 3044 dbSNP
rs15645 3049 dbSNP
rs1391292008 3054 dbSNP
rs1436355409 3055 dbSNP
rs869034463 3058 dbSNP
rs1308826351 3061 dbSNP
rs997248467 3061 dbSNP
rs1237999446 3063 dbSNP
rs1330194250 3066 dbSNP
rs111509060 3070 dbSNP
rs11398735 3070 dbSNP
rs1230565021 3070 dbSNP
rs397724114 3070 dbSNP
rs535528051 3070 dbSNP
rs1033948003 3075 dbSNP
rs1466185813 3077 dbSNP
rs1209172579 3080 dbSNP
rs1379218530 3081 dbSNP
rs1201212242 3082 dbSNP
rs1247378950 3082 dbSNP
rs200240393 3082 dbSNP
rs1310562800 3083 dbSNP
rs566258154 3087 dbSNP
rs1448021549 3093 dbSNP
rs1472267045 3095 dbSNP
rs1357784960 3099 dbSNP
rs192040695 3105 dbSNP
rs1414900437 3114 dbSNP
rs1458203062 3118 dbSNP
rs1163075322 3122 dbSNP
rs1415799851 3131 dbSNP
rs1375626801 3133 dbSNP
rs900155359 3134 dbSNP
rs13173132 3135 dbSNP
rs868312678 3136 dbSNP
rs6882312 3137 dbSNP
rs1056045 3138 dbSNP
rs7721896 3139 dbSNP
rs200391443 3140 dbSNP
rs867834275 3141 dbSNP
rs113096177 3142 dbSNP
rs1391905895 3142 dbSNP
rs1491037227 3142 dbSNP
rs10609501 3143 dbSNP
rs375452482 3143 dbSNP
rs138156987 3144 dbSNP
rs199517991 3145 dbSNP
rs1014206436 3146 dbSNP
rs1276884346 3146 dbSNP
rs199658748 3146 dbSNP
rs773237274 3147 dbSNP
rs1487465746 3148 dbSNP
rs758481941 3148 dbSNP
rs1184631962 3149 dbSNP
rs1286920881 3149 dbSNP
rs1228221201 3150 dbSNP
rs1491561002 3150 dbSNP
rs1301737933 3151 dbSNP
rs1400033173 3151 dbSNP
rs1491519638 3151 dbSNP
rs1397673715 3152 dbSNP
rs565168735 3153 dbSNP
rs1315501143 3154 dbSNP
rs1377688618 3155 dbSNP
rs10038061 3157 dbSNP
rs10038060 3160 dbSNP
rs1007109058 3161 dbSNP
rs1226473912 3162 dbSNP
rs1300182783 3163 dbSNP
rs1308291513 3164 dbSNP
rs375378601 3164 dbSNP
rs114959506 3165 dbSNP
rs563147489 3177 dbSNP
rs10043606 3182 dbSNP
rs1048682209 3193 dbSNP
rs1340310074 3197 dbSNP
rs147430614 3205 dbSNP
rs1003333529 3208 dbSNP
rs1417550756 3219 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions TZM-bl
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM1462574. RNA binding protein: AGO2. Condition:TZM-bl ami BaL ...

- Whisnant AW; Bogerd HP; Flores O; Ho P; et al., 2013, mBio.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' ucuGGGGAGGAGGUAGg 5'
             ||||||| ||| | 
Target 5' cauCCCCUCCCCCACCu 3'
 		2 - 18
Article - Whisnant AW; Bogerd HP; Flores O; Ho P; et al.
- mBio, 2013
UNLABELLED: The question of how HIV-1 interfaces with cellular microRNA (miRNA) biogenesis and effector mechanisms has been highly controversial. Here, we first used deep sequencing of small RNAs present in two different infected cell lines (TZM-bl and C8166) and two types of primary human cells (CD4(+) peripheral blood mononuclear cells [PBMCs] and macrophages) to unequivocally demonstrate that HIV-1 does not encode any viral miRNAs. Perhaps surprisingly, we also observed that infection of T cells by HIV-1 has only a modest effect on the expression of cellular miRNAs at early times after infection. Comprehensive analysis of miRNA binding to the HIV-1 genome using the photoactivatable ribonucleoside-induced cross-linking and immunoprecipitation (PAR-CLIP) technique revealed several binding sites for cellular miRNAs, a subset of which were shown to be capable of mediating miRNA-mediated repression of gene expression. However, the main finding from this analysis is that HIV-1 transcripts are largely refractory to miRNA binding, most probably due to extensive viral RNA secondary structure. Together, these data demonstrate that HIV-1 neither encodes viral miRNAs nor strongly influences cellular miRNA expression, at least early after infection, and imply that HIV-1 transcripts have evolved to avoid inhibition by preexisting cellular miRNAs by adopting extensive RNA secondary structures that occlude most potential miRNA binding sites. IMPORTANCE: MicroRNAs (miRNAs) are a ubiquitous class of small regulatory RNAs that serve as posttranscriptional regulators of gene expression. Previous work has suggested that HIV-1 might subvert the function of the cellular miRNA machinery by expressing viral miRNAs or by dramatically altering the level of cellular miRNA expression. Using very sensitive approaches, we now demonstrate that neither of these ideas is in fact correct. Moreover, HIV-1 transcripts appear to largely avoid regulation by cellular miRNAs by adopting an extensive RNA secondary structure that occludes the ability of cellular miRNAs to interact with viral mRNAs. Together, these data suggest that HIV-1, rather than seeking to control miRNA function in infected cells, has instead evolved a mechanism to become largely invisible to cellular miRNA effector mechanisms.
LinkOut: [PMID: 23592263]
CLIP-seq Support 1 for dataset GSM4903829
Method / RBP HITS-CLIP / AGO
Cell line / Condition Human neurons / CTLTD_shCTL_a
Location of target site NM_171825 | 3UTR | CUCCAUCCCCUCCCCCAC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161238
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM4903830
Method / RBP HITS-CLIP / AGO
Cell line / Condition Human neurons / CTLTD_shCTL_b
Location of target site NM_015981 | 3UTR | CUCCAUCCCCUCCCCCAC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161238
CLIP-seq Viewer Link
CLIP-seq Support 3 for dataset GSM4903831
Method / RBP HITS-CLIP / AGO
Cell line / Condition Human neurons / 124TD_shELAVL3_a
Location of target site NM_015981 | 3UTR | CUCCAUCCCCUCCCCCAC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161238
CLIP-seq Viewer Link
CLIP-seq Support 4 for dataset GSM4903832
Method / RBP HITS-CLIP / AGO
Cell line / Condition Human neurons / 124TD_shELAVL3_b
Location of target site NM_171825 | 3UTR | CUCCAUCCCCUCCCCCAC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161238
CLIP-seq Viewer Link
CLIP-seq Support 5 for dataset GSM4903833
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / CTL_TD_21_a
Location of target site NM_171825 | 3UTR | CUCCAUCCCCUCCCCCAC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 6 for dataset GSM4903834
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / CTL_TD_21_b
Location of target site NM_171825 | 3UTR | CUCCAUCCCCUCCCCCAC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 7 for dataset GSM4903835
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / CTL_TD_21_c
Location of target site NM_171825 | 3UTR | CUCCAUCCCCUCCCCCAC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 8 for dataset GSM4903836
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / 124_TD_21_a
Location of target site NM_171825 | 3UTR | CUCCAUCCCCUCCCCCAC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 9 for dataset GSM4903837
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / 124_TD_21_b
Location of target site NM_171825 | 3UTR | CUCCAUCCCCUCCCCCAC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 10 for dataset GSM4903838
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / 124_TD_21_c
Location of target site NM_171825 | 3UTR | CUCCAUCCCCUCCCCCAC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 11 for dataset GSM1462574
Method / RBP PAR-CLIP / AGO2
Cell line / Condition TZM-bl / TZM-bl ami BaL
Location of target site ENST00000348628.6 | 3UTR | CCAUCCCCUCCCCCACCUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23592263 / GSE59944
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
141 hsa-miR-4534 Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT087131 CRKL CRK like proto-oncogene, adaptor protein 2 2
MIRT179641 CAPZA1 capping actin protein of muscle Z-line alpha subunit 1 2 2
MIRT243304 SLC25A36 solute carrier family 25 member 36 2 2
MIRT325574 HIATL1 major facilitator superfamily domain containing 14B 2 4
MIRT448776 GNA13 G protein subunit alpha 13 2 2
MIRT451456 HSD11B1L hydroxysteroid 11-beta dehydrogenase 1 like 2 2
MIRT452150 PPP2R1B protein phosphatase 2 scaffold subunit Abeta 2 2
MIRT454199 HLA-A major histocompatibility complex, class I, A 2 2
MIRT455984 ENPP5 ectonucleotide pyrophosphatase/phosphodiesterase 5 (putative) 2 2
MIRT456058 SLC25A28 solute carrier family 25 member 28 2 2
MIRT457082 XPNPEP3 X-prolyl aminopeptidase 3 2 2
MIRT457278 ALDH9A1 aldehyde dehydrogenase 9 family member A1 2 2
MIRT457361 POFUT2 protein O-fucosyltransferase 2 2 2
MIRT457396 CAMK2A calcium/calmodulin dependent protein kinase II alpha 2 2
MIRT458817 ZNF843 zinc finger protein 843 2 2
MIRT459697 VPS37C VPS37C, ESCRT-I subunit 2 2
MIRT460346 ARL14EP ADP ribosylation factor like GTPase 14 effector protein 2 2
MIRT462713 MAPK13 mitogen-activated protein kinase 13 2 2
MIRT464278 VASH1 vasohibin 1 2 2
MIRT465634 TNRC18P2 trinucleotide repeat containing 18 pseudogene 2 2 10
MIRT465772 TMOD3 tropomodulin 3 2 2
MIRT466414 TFDP1 transcription factor Dp-1 2 2
MIRT467122 SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 2 8
MIRT467475 SMYD1 SET and MYND domain containing 1 2 4
MIRT468462 SET SET nuclear proto-oncogene 2 2
MIRT468618 SUMO1 small ubiquitin-like modifier 1 2 2
MIRT468835 RRM2 ribonucleotide reductase regulatory subunit M2 2 4
MIRT470890 PLXND1 plexin D1 2 2
MIRT473226 SMCR7L mitochondrial elongation factor 1 2 4
MIRT473858 MAP2K4 mitogen-activated protein kinase kinase 4 2 2
MIRT474975 KCND3 potassium voltage-gated channel subfamily D member 3 2 2
MIRT475858 H6PD hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase 2 2
MIRT478569 CTNND1 catenin delta 1 2 2
MIRT479347 CEP97 centrosomal protein 97 2 2
MIRT479910 CCDC117 coiled-coil domain containing 117 2 4
MIRT480122 CALR calreticulin 2 2
MIRT480892 BCL9L B-cell CLL/lymphoma 9 like 2 2
MIRT481149 AVL9 AVL9 cell migration associated 2 6
MIRT481527 ARL5B ADP ribosylation factor like GTPase 5B 2 10
MIRT481896 ANKRD40 ankyrin repeat domain 40 2 2
MIRT490138 FN3K fructosamine 3 kinase 2 4
MIRT490329 ANK1 ankyrin 1 2 4
MIRT491472 TMEM214 transmembrane protein 214 2 2
MIRT503552 TIGIT T-cell immunoreceptor with Ig and ITIM domains 2 4
MIRT504413 TUBA1B tubulin alpha 1b 2 4
MIRT508207 SLC35E1 solute carrier family 35 member E1 2 2
MIRT508333 SLC37A4 solute carrier family 37 member 4 2 6
MIRT516381 TRAF3IP2 TRAF3 interacting protein 2 2 4
MIRT518549 ABCA6 ATP binding cassette subfamily A member 6 2 2
MIRT522545 MED28 mediator complex subunit 28 2 6
MIRT522592 MAPK1IP1L mitogen-activated protein kinase 1 interacting protein 1 like 2 2
MIRT522923 KAT6A lysine acetyltransferase 6A 2 4
MIRT525937 C11orf74 chromosome 11 open reading frame 74 2 2
MIRT527021 PABPN1L poly(A) binding protein nuclear 1 like, cytoplasmic 2 2
MIRT530396 SULT1B1 sulfotransferase family 1B member 1 2 2
MIRT530660 TRIM56 tripartite motif containing 56 2 2
MIRT531625 TM4SF5 transmembrane 4 L six family member 5 2 4
MIRT532703 TCN2 transcobalamin 2 2 4
MIRT540173 MB21D1 Mab-21 domain containing 1 2 2
MIRT540756 UTP6 UTP6, small subunit processome component 2 2
MIRT541966 ZNF485 zinc finger protein 485 2 2
MIRT542738 RAF1 Raf-1 proto-oncogene, serine/threonine kinase 2 2
MIRT543090 KNSTRN kinetochore localized astrin/SPAG5 binding protein 2 2
MIRT550687 YARS tyrosyl-tRNA synthetase 2 2
MIRT553466 TNRC6A trinucleotide repeat containing 6A 2 2
MIRT559980 RELA RELA proto-oncogene, NF-kB subunit 2 2
MIRT561084 LLPH LLP homolog, long-term synaptic facilitation 2 2
MIRT561738 PLAGL2 PLAG1 like zinc finger 2 2 2
MIRT569872 KLK10 kallikrein related peptidase 10 2 2
MIRT570264 ARPC3 actin related protein 2/3 complex subunit 3 2 2
MIRT573431 ALDOA aldolase, fructose-bisphosphate A 2 2
MIRT573874 PRPS1L1 phosphoribosyl pyrophosphate synthetase 1-like 1 2 2
MIRT576905 Poteg POTE ankyrin domain family, member G 2 2
MIRT607934 ANG angiogenin 2 2
MIRT609472 RPL7L1 ribosomal protein L7 like 1 2 4
MIRT612179 EMC3 ER membrane protein complex subunit 3 2 2
MIRT613428 GALNT6 polypeptide N-acetylgalactosaminyltransferase 6 2 2
MIRT613746 GPR155 G protein-coupled receptor 155 2 2
MIRT615034 DIS3 DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease 2 2
MIRT615565 JPH2 junctophilin 2 2 2
MIRT615937 MAP1LC3B microtubule associated protein 1 light chain 3 beta 2 2
MIRT616643 LRAT lecithin retinol acyltransferase 2 4
MIRT630890 SLC25A33 solute carrier family 25 member 33 2 2
MIRT636542 FAM126B family with sequence similarity 126 member B 2 2
MIRT641392 NUBPL nucleotide binding protein like 2 2
MIRT641410 SCN2B sodium voltage-gated channel beta subunit 2 2 2
MIRT643184 HYPK huntingtin interacting protein K 2 2
MIRT652600 TIMM8A translocase of inner mitochondrial membrane 8A 2 2
MIRT653974 SEMA7A semaphorin 7A (John Milton Hagen blood group) 2 2
MIRT655692 NUDT3 nudix hydrolase 3 2 2
MIRT660734 ALG14 ALG14, UDP-N-acetylglucosaminyltransferase subunit 2 4
MIRT661604 C2orf15 chromosome 2 open reading frame 15 2 2
MIRT663284 ZNF675 zinc finger protein 675 2 2
MIRT666337 SKAP2 src kinase associated phosphoprotein 2 2 2
MIRT666636 RBMS2 RNA binding motif single stranded interacting protein 2 2 2
MIRT667125 OCIAD2 OCIA domain containing 2 2 2
MIRT670412 ELP2 elongator acetyltransferase complex subunit 2 2 2
MIRT671119 ZNF573 zinc finger protein 573 2 2
MIRT671152 ANKRD9 ankyrin repeat domain 9 2 2
MIRT671336 FAM71F2 family with sequence similarity 71 member F2 2 2
MIRT671867 ZNF429 zinc finger protein 429 2 2
MIRT671972 IKZF3 IKAROS family zinc finger 3 2 2
MIRT672062 KIAA0930 KIAA0930 2 2
MIRT672652 SLC25A16 solute carrier family 25 member 16 2 4
MIRT672671 GTF2H5 general transcription factor IIH subunit 5 2 2
MIRT672768 UBE2V2 ubiquitin conjugating enzyme E2 V2 2 2
MIRT672927 LRRC2 leucine rich repeat containing 2 2 2
MIRT673156 C1orf50 chromosome 1 open reading frame 50 2 2
MIRT673270 RUNDC1 RUN domain containing 1 2 2
MIRT673329 THAP1 THAP domain containing 1 2 2
MIRT673348 SLC35F6 solute carrier family 35 member F6 2 2
MIRT673664 ZNF440 zinc finger protein 440 2 2
MIRT673901 DCTN6 dynactin subunit 6 2 2
MIRT674399 MYCBP MYC binding protein 2 2
MIRT674523 PRR23A proline rich 23A 2 2
MIRT674831 ADAMTS4 ADAM metallopeptidase with thrombospondin type 1 motif 4 2 2
MIRT675064 FGD6 FYVE, RhoGEF and PH domain containing 6 2 2
MIRT675078 CCR6 C-C motif chemokine receptor 6 2 2
MIRT675123 FSD2 fibronectin type III and SPRY domain containing 2 2 2
MIRT679399 IL10RB interleukin 10 receptor subunit beta 2 2
MIRT686608 TMEM70 transmembrane protein 70 2 2
MIRT690371 ZSWIM7 zinc finger SWIM-type containing 7 2 2
MIRT694464 LRTOMT leucine rich transmembrane and O-methyltransferase domain containing 2 2
MIRT695706 OLA1 Obg like ATPase 1 2 2
MIRT696846 WDR13 WD repeat domain 13 2 2
MIRT700894 PER2 period circadian clock 2 2 2
MIRT701924 MLLT1 MLLT1, super elongation complex subunit 2 2
MIRT704918 CCDC36 coiled-coil domain containing 36 2 2
MIRT706211 ACOT9 acyl-CoA thioesterase 9 2 2
MIRT706546 GJD2 gap junction protein delta 2 2 2
MIRT706727 RFK riboflavin kinase 2 2
MIRT707366 ORAI2 ORAI calcium release-activated calcium modulator 2 2 2
MIRT707416 RRP7A ribosomal RNA processing 7 homolog A 2 2
MIRT710646 GLUL glutamate-ammonia ligase 2 2
MIRT712298 PGM2L1 phosphoglucomutase 2 like 1 2 2
MIRT713709 HIST3H2BB histone cluster 3 H2B family member b 2 2
MIRT713751 SLC9A8 solute carrier family 9 member A8 2 2
MIRT716423 VPS53 VPS53, GARP complex subunit 2 2
MIRT717169 UCHL3 ubiquitin C-terminal hydrolase L3 2 2
MIRT718877 PDIA3 protein disulfide isomerase family A member 3 2 2
MIRT720096 SPTLC3 serine palmitoyltransferase long chain base subunit 3 2 2
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-4 Dexamethasone approved 5743 Microarray primary rat thymocytes 20847043 2010 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-4534 Platinum 23939 sensitive High Ovarian Cancer tissue
hsa-miR-4534 Fluorouracil 3385 NSC19893 approved sensitive High Pancreatic Cancer cell line (PATU8988)
hsa-miR-4534 Dabrafenib 44462760 NSC764134 approved sensitive High Melanoma cell line (A375, IGR37, 501Mel)
hsa-miR-4534 Vemurafenib 42611257 NSC761431 approved sensitive High Melanoma cell line (A375, IGR37, 501Mel)
hsa-miR-4534 Fulvestrant 17756771 NSC719276 approved resistant High Breast Cancer cell line (MCF-7)
hsa-miR-4534 Tamoxifen 2733525 NSC180973 approved resistant High Breast Cancer cell line (MCF-7)
hsa-mir-4534 Androstenedione+Anastrozole sensitive cell line (MCF-7)
hsa-mir-4534 Cisplatin 5460033 NSC119875 approved resistant cell line (BxPC3)
hsa-miR-4534 Cisplatin 5460033 NSC119875 approved resistant cell line (CAL-27) (cytosolic RNA)
hsa-miR-4534 Doxorubicin 31703 NSC123127 approved sensitive cell line (BAS)
hsa-miR-4534 Osimertinib 71496458 NSC779217 approved sensitive cell line (H1975)
hsa-miR-4534 Paclitaxel 36314 NSC125973 approved resistant cell line (A2780)
hsa-miR-4534 Cisplatin 5460033 NSC119875 approved resistant cell line (A2780)
hsa-miR-4534 Platinum 23939 resistant tissue
hsa-miR-4534 Gemcitabine 60750 NSC613327 approved sensitive cell line (PANC-1) (1500 ng/ml)
hsa-miR-4534 Gemcitabine 60750 NSC613327 approved sensitive cell line (PANC-1) (100 ng/ml)
hsa-miR-4534 Cisplatin 5460033 NSC119875 approved resistant cell line (A549)

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