miRTarBase - #MIRT457761


—
pre-miRNA Information
pre-miRNA hsa-mir-4651   
Genomic Coordinates chr7: 75915197 - 75915269
Description Homo sapiens miR-4651 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-4651
Sequence 10| CGGGGUGGGUGAGGUCGGGC |29
Evidence Experimental
Experiments Illumina
DRVs in miRNA
Mutant ID Mutant Position Mutant Source
COSN30595227 5 COSMIC
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1458858872 1 dbSNP
rs887877274 2 dbSNP
rs559953168 4 dbSNP
rs1332072774 12 dbSNP
rs868980356 12 dbSNP
rs1291879524 14 dbSNP
rs1228835859 19 dbSNP
rs1349605668 19 dbSNP
rs1277626081 20 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol ZC3H12B   
Synonyms CXorf32, MCPIP2
Description zinc finger CCCH-type containing 12B
Transcript NM_001010888   
Expression
Putative miRNA Targets on ZC3H12B
3'UTR of ZC3H12B
(miRNA target sites are highlighted)		 
>ZC3H12B|NM_001010888|3'UTR
   1 TATGACATAGTACTTATTTCTTTATACAAATATGAATATTAATACTAATAATACACTAATACAATAATTATAGTAACTAA
  81 TAATTTGTGTTGCGCTTTACAAGTTAGAGTGTTTATATCATTTAAGCGCTTAACAACCCTGTGAGGTACGTCTTACTAAC
 161 ATCCTCTTTTATAGAGAAGGAAGGTGAAGGTCAGTGAAATTAAGTGGCTAGCCAGGGTCACACTGCTAGCAAATGACTAA
 241 GTCAAGACACACACCCAAGTCCTCTAAATCCAAGTCCCATGCCCCTTTGCACTGCACCATGCAGGTAATGGAGGACAAAA
 321 CCCAGGGGGAGAGGTCTAGATGTAAGAAATCCCAGAGGATTCCATTACCAGAGTTTTCCTTTTTCTCTTTTCGTTTCTTT
 401 CTTTCTTTCTTTATTTTTTTTTTTTGAGACAGAATCTCACTCTGTTACACAGGCTGGAGTGCAGTGGCACTATCTCTGCT
 481 CACTGCAACCTCCACCTCCAGGGTTCAAGTGATTCTATGGCCTCAGCCTCCCAGGTAGCTGGGATTACAGGCGTGCACCA
 561 CCATGCCCAGCTAATTTTTGTATTTTTAGTAGAGACGTGGTTTCACCGTGTTGGCCAGGCTGGTCTCAAACTCCTGGCCT
 641 CAAGTGATCCGCCCACCTTGGCCTCCTAAAGTGCTGGGATTACAGGTGTGAGCCACTGCGCCCAGCCTACCAGAGTTTTC
 721 GTAGTCACATATTCTATATTACAAAGTATGGATGATATATCCAATTTAGAGAGCAAAAGCATCAGGATCAGATCATATGT
 801 TGAATTAACCTTTTAGGTTTTTTCTAATAGAAATATTTAAAGCTATTTAAAAGTAAATGCATACTTTATTGCATGGATAT
 881 CTGATCACTCAATCTATATTAATGAAACTATAGGGTCACATTGAAGCTTCTAGAACTATATTTTAAAGCTATTATTAGCA
 961 ATTATATTGCATGTATGAATATATATATTTGGTTTGAGATGTGTGTGTATCTCTGTATAACCTTTTATATAGTGATAATG
1041 AGAGGGTAGGCTCTACACAGTCCTTCGTCTATAGCTGTATAGGTCACTAATCTGACTTGATGATTTTAAGTCACATTTCA
1121 TAGTTTTAACTAGTTATGAGAGAGAAATTATATGGCAATATTTGAACATTGCTTTCTTAGGCACCAGAGCAAAGCAACTC
1201 TGTTTCCTTTGCACATTTTACCTGCCAACATTTATTAACAGTTCTTACCTTCCAAGTCTCTTCACCTTAGCAAATTAGGG
1281 ATCAGGTTGCAGTCTTCTGCAGAGAAACTGATGGTTAAGCTCAAGTTCCAAGCATAGTATGTGTGTGCTACACAAGCTCA
1361 GAAGAGTTTGACAAGGACCAGGGGACTTACTACCACAATCCACTTCCCTTATCCCAGGAGAGATGGCCAAACCCATGTGG
1441 CATTAAATGGTGAATAAAAAAGCTTCACTCAAGGAGGGACTATTGGATGCTCTTTGGACTTCTGACCTATGCAGTATTCA
1521 ACATCATTGGATGAAATGTAATGGAGGACAGTGCACAGCCATGTATCCACTTTCTCTTCCTGTCCACCCTTTGGGTAATA
1601 AGGTCAATCATTGGTGGAACAGAATTTCTCTAGGAAACAAAACCAGGGGATTTTATTTGTGGAAAAAGGAAGTTTCCAAA
1681 AGGGGATACTGCATCTTTACTAATAGCTGGCTCAGTTACTCACTTTAAATCCATGCAAAGAGTGCACTTGCTGTTAAATA
1761 ATTGTTAAATGAGTTATTAGAAGGCAGGACTTTTGGTTTGGGCGACACCATTTGCGCAACTTGTATCTTGCTCAGGGTGG
1841 AAAACTTCATAGCTAAATGCCTCTAGAAGAGGTGTTTATTGTTTTTTTTAAGCTGCACTAAATGAATTCCCTTTTTGAAT
1921 CCATTGTATATTTCAATATTTCGAACCATGATCAGCTCACTATTTCCTGAGCTGGAACTTGCTAACTTCTATGATCGTTT
2001 TTTCATGAAAGTTGAGAAGGCCGGGCCTTGGCCTTTTGTTTCTTCATGAGAAGGTGTGACACTGCCTATAAATGTTTCTT
2081 ACTGTGAAACACTCTGAATGTGAGGCTGTAGTCAGGGTTGTTTCTGGTGGTTTGACAATGGCTTGCATGCTGCTTTCTGG
2161 CTTTCTGTCTCTGTCCAAGTTGATCAATACTGCATCTTAACCAATGTTTCACTTGAGTTAACCACAGCTTTACATTCTAT
2241 CTCCTATCTTCTGATCTTCGTATACCCCAGCATATTGAAAAAGAGTAAAAGTATTTTCTATCAATCAGGTAGATCCACAG
2321 AGTGACAGTTGCCACTGCAGTGCTTGCTATTTCACACAAACACCATTTCATACCTTCAACTTCTTGGACTTTCTAAATCG
2401 GACTCGTGTCTAAATCAGGGTATTTGACAATCTCAGATGATGCTACTGCCTATGTGCCAGTTAGTTCATCTTCCTACCAA
2481 GATCATGAATGGCACCACACTATCCACTAGCTGTACAATTTACAGAGAAGCACAAGATTCATCTTGTCACCTACAATTCG
2561 TCTTGAACATGTTCATATTTAGTACTCAGAAACTGTGTAAGCTCCTCCCAATACAGAAAATATTTTTTAAGGCAGCATAT
2641 GTATTTCTGATTTACTAAAAACGATTGTCATTCTCCTCTCATTCTTCTTTTTGGTATGAACCAAAAGCGGCTAGGAGCAA
2721 TGCCTCAAATAACCAGAAATGACCTTTTGTTGATACAAATTGTATCTCTTTTTTTCCTGATTGTATAGAAACAAATGTAC
2801 AAAACTCATCTGAAGCTAGGTTTGGCACTGAATTTTCACCATGAGGTTTGTGGCACTGTGTGTCACAGGGAAGTAGCTCA
2881 GGGGTTGTGAGGGAGCTTTTATTTCTAAAGGGCAGTAGTAATTTATAGACAAAAACAATTTTTCAAGGCCTCTTTATTAC
2961 CACTGCACAGCTATCATGTGTAAAATTTCAAGCATTATATTGCATAAGTTCTCTTTAGCCTATTAAATTTAATATGTCCT
3041 TGCAAAAGGGATTTTGTGTAAAAAGTGTCAGTGTTAGTGACTCATCTGCAAGAATCTACAAATGGAGCTATACAACTATG
3121 AATACATAAATACAGCATGGTTCCTAGTTATTAGAGAAACATTTTCTTTATATTGAGGTCTACGCACTTCTTGACTTTCC
3201 ATTTTGTCTGTAATTATAAAACAGCAAATAACAAAGAAGCATTGGGACCCCCTCGGCTGCCTTGATAATAAAATCAAGCT
3281 TCCTTCATGGGACTAAGCATGTGTCCTTCAGGATACTTACCTCTAAGCACTCAGCAGGGGTTACTACAAAGCGTTTTGTG
3361 TGGTTTTCAAAAAACAGTGTATTTTGCAAGAGGTGCTTTGTAATTTTAATTATTTCACTGATTTTCTGACCTCATAGGAA
3441 GTCTGTGCCTGTTGAGGCCTTCAATTTTGTAGCTTTTCTGATTTTTTTTCTTCTTTTTGTGATTTTGTTGTTGTTTTCAT
3521 TTTGATCTAAAGGAGAAGTGTGACCCCGGAGTGGCATGGTCAATCCAGGGCACCCTTTCTGTAAGACAACTCAAAGGAAA
3601 AGAAGCCTTTTCAAAGGTAATATCGAGCCATTGCACTCTCTCTTAAGGTGCCAGGTATGGGAGAATGACAGATGCCTTAT
3681 GGAAATGGTCTACAAAACTTTTCTTCTTCTAAGTAATAAAACACATAGCATGATTCTCTCTCCCTCTCTCTCTCTCTCTC
3761 TGCCCACCCCCTGCTAGTTTCCAGGAGAATACTTCTCTAAAATTCATTTTTTTCTATTTTGGAATAAATTATCTTTATAC
3841 AGTAATTCAAACACTGATTTCCATTAACCTTTGGCCCTGAGTTTTCTTCTAACATAGAAGAGTTCATTTTGAGAGGCACT
3921 CAGTTACCATTCAATCTGTGCTGTAAGTATGGGACTTTGTACAAATGCCCTTTTTGAGGGCCAAAAATTTCAATACACTT
4001 TGTTCTACTTTGTGAACCAGGTCTGGATCTGCACAGAGAAAGTAATGCTGAGCTGTCCAAAGAGTCCGCTCAGGTCTCCC
4081 TCCTAACCCTCCTCTGCCTTCCCCTAGTTTGCTTATCCTCACGTCTGACACTGAGGAGTGCATAGTCTTCAACTGAAATG
4161 GCACTACAGTTAGTTCTCATTGGAAACAAACAAGTGTATTTCTGGAACCTGCTCGTCTAAAATAGTCAATGCCTTTGTAA
4241 AGACTCAGCATATTCAATATCTATTGTATGGTAGCTAGCTATATACATAGATTGACTATTTTTAGTCCTGGTTTGTGTAT
4321 TGTTGAGCTATAGTAGTTTGCTTTATCCATTTGTGGGATTAAACAATACTGTTTAATGGTTGTAAACTTTTATAAAATCT
4401 CTTTGGGTTTTTTGTTTGACCCAAACATAATGTAAGTCTTAATGACAAAATACACAAAGTTAACCAGAGGTGAGTGAAAA
4481 TATAGCCCTTCCCCAGTTTTGTCTGCCCCTATAATGCACGTGCATTGCTTTGTAATATGCTCTCGCTAGCATGAATGTGC
4561 TATGACTACTTCATGAGGTTTTGTTTCACCTATAATTGTGATGGAAAATGCTGTATTGCTGACAACAATGAACTGTAACC
4641 ACAGTTATTTACTGCATAAACTATTTGTGTACTAACCAAAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' cgggcuGGAG-UGGGUGGGGc 5'
                :||| :|||||||| 
Target 5' tctctcTCTCTGCCCACCCCc 3'
 3751 - 3771 154.00 -25.30
2 
miRNA  3' cgGGCUGGAGU---GGGUGGGGc 5'
            |: ||: ||   :|||||:| 
Target 5' tgCTCACTGCAACCTCCACCTCc 3'
 477 - 499 134.00 -19.00
3 
miRNA  3' cgggcuGGAGUGGGUGGGGc 5'
                ||| ::||||||: 
Target 5' tctcttCCT-GTCCACCCTt 3'
 1573 - 1591 133.00 -19.40
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs749118677 4 dbSNP
rs986274702 8 dbSNP
rs182944757 9 dbSNP
rs1425615831 12 dbSNP
rs1239745739 26 dbSNP
rs769835730 28 dbSNP
rs775772456 33 dbSNP
rs749528155 40 dbSNP
rs1289504057 45 dbSNP
rs750196139 46 dbSNP
rs1163512766 67 dbSNP
rs910749592 68 dbSNP
rs1381847892 80 dbSNP
rs1156476825 84 dbSNP
rs1438148935 84 dbSNP
rs1237987938 93 dbSNP
rs765868392 94 dbSNP
rs778715695 95 dbSNP
rs1489783481 103 dbSNP
rs1474928158 104 dbSNP
rs747660643 107 dbSNP
rs771767631 121 dbSNP
rs558289193 128 dbSNP
rs761043265 129 dbSNP
rs1013892478 145 dbSNP
rs1488665573 147 dbSNP
rs1288342016 164 dbSNP
rs1238282068 166 dbSNP
rs1020878256 173 dbSNP
rs966904343 183 dbSNP
rs1220847952 187 dbSNP
rs903439661 205 dbSNP
rs934688545 218 dbSNP
rs372283632 224 dbSNP
rs1430754155 225 dbSNP
rs1054825391 231 dbSNP
rs186910354 236 dbSNP
rs1418738707 241 dbSNP
rs1380053448 245 dbSNP
rs1032209387 257 dbSNP
rs1177332447 260 dbSNP
rs576630762 283 dbSNP
rs1423613497 289 dbSNP
rs192719288 294 dbSNP
rs1265451088 310 dbSNP
rs1326081769 326 dbSNP
rs12014994 328 dbSNP
rs905052853 336 dbSNP
rs544097750 343 dbSNP
rs1488107981 349 dbSNP
rs965088753 355 dbSNP
rs1212046960 365 dbSNP
rs1224856725 370 dbSNP
rs1300428699 382 dbSNP
rs1219207366 384 dbSNP
rs1341784060 384 dbSNP
rs1275813619 386 dbSNP
rs1398975238 389 dbSNP
rs1375741368 393 dbSNP
rs187558412 393 dbSNP
rs1357814332 394 dbSNP
rs371453149 394 dbSNP
rs771754312 394 dbSNP
rs1341975130 398 dbSNP
rs1034942135 407 dbSNP
rs1191685470 409 dbSNP
rs1219736428 409 dbSNP
rs201727012 410 dbSNP
rs746891695 410 dbSNP
rs868847278 410 dbSNP
rs1199172716 411 dbSNP
rs1491250283 412 dbSNP
rs200726792 412 dbSNP
rs1491405860 413 dbSNP
rs368479377 413 dbSNP
rs1336528071 414 dbSNP
rs2038283 414 dbSNP
rs5902584 414 dbSNP
rs764122160 414 dbSNP
rs1332687173 415 dbSNP
rs1215652246 417 dbSNP
rs1049213338 418 dbSNP
rs1253770167 420 dbSNP
rs1369162877 425 dbSNP
rs1191354072 427 dbSNP
rs869241580 427 dbSNP
rs1243611102 428 dbSNP
rs1422337370 434 dbSNP
rs1255180221 435 dbSNP
rs1179096504 436 dbSNP
rs751693450 440 dbSNP
rs909414836 454 dbSNP
rs1003974361 461 dbSNP
rs1164079974 473 dbSNP
rs755956633 476 dbSNP
rs1356374295 490 dbSNP
rs938072979 501 dbSNP
rs1242119809 502 dbSNP
rs1320812081 528 dbSNP
rs1055147850 542 dbSNP
rs1447910170 553 dbSNP
rs896444453 554 dbSNP
rs1329863607 559 dbSNP
rs1013590390 562 dbSNP
rs1042820289 567 dbSNP
rs1164987795 568 dbSNP
rs951732446 572 dbSNP
rs757647829 574 dbSNP
rs1380134669 589 dbSNP
rs1384777830 598 dbSNP
rs1441272576 601 dbSNP
rs1378276918 605 dbSNP
rs910299314 608 dbSNP
rs1001218766 609 dbSNP
rs966216531 612 dbSNP
rs779470862 624 dbSNP
rs1207609665 628 dbSNP
rs766354786 651 dbSNP
rs1286209182 652 dbSNP
rs1241915939 654 dbSNP
rs753624788 664 dbSNP
rs1032157057 677 dbSNP
rs953880050 678 dbSNP
rs1293154881 697 dbSNP
rs754892473 700 dbSNP
rs1054477170 701 dbSNP
rs1019384473 705 dbSNP
rs914588198 709 dbSNP
rs965377025 721 dbSNP
rs972424076 722 dbSNP
rs1378213692 723 dbSNP
rs1266078433 735 dbSNP
rs1157845908 741 dbSNP
rs750644532 747 dbSNP
rs907250172 749 dbSNP
rs1003378192 753 dbSNP
rs950984356 770 dbSNP
rs758763406 775 dbSNP
rs897753025 782 dbSNP
rs778697297 786 dbSNP
rs140269552 794 dbSNP
rs1186971495 797 dbSNP
rs1177425134 802 dbSNP
rs758098448 804 dbSNP
rs1204976479 810 dbSNP
rs375918886 812 dbSNP
rs1346154528 816 dbSNP
rs777096934 818 dbSNP
rs909355908 818 dbSNP
rs938189212 825 dbSNP
rs780270861 838 dbSNP
rs918003828 847 dbSNP
rs1402071344 864 dbSNP
rs951839752 865 dbSNP
rs1317921114 868 dbSNP
rs949531724 872 dbSNP
rs746538759 891 dbSNP
rs1404129010 893 dbSNP
rs1170694660 901 dbSNP
rs1017316388 909 dbSNP
rs1423685513 920 dbSNP
rs1195300101 930 dbSNP
rs1476629139 950 dbSNP
rs192803305 984 dbSNP
rs976240081 985 dbSNP
rs1443303781 986 dbSNP
rs902534872 994 dbSNP
rs1199214169 1010 dbSNP
rs1323523564 1012 dbSNP
rs1385243132 1014 dbSNP
rs1258776114 1019 dbSNP
rs1433778197 1037 dbSNP
rs777188571 1053 dbSNP
rs1353999466 1057 dbSNP
rs1053717906 1059 dbSNP
rs368727976 1068 dbSNP
rs1006733543 1073 dbSNP
rs1342023813 1075 dbSNP
rs914828296 1079 dbSNP
rs1469225402 1093 dbSNP
rs1019905697 1104 dbSNP
rs1401016686 1121 dbSNP
rs900913578 1122 dbSNP
rs1044376364 1126 dbSNP
rs1418192301 1130 dbSNP
rs1335205578 1138 dbSNP
rs1473597939 1141 dbSNP
rs1239570477 1159 dbSNP
rs1182189716 1168 dbSNP
rs1461154437 1178 dbSNP
rs770191848 1183 dbSNP
rs1239248653 1194 dbSNP
rs1201110200 1198 dbSNP
rs928721560 1240 dbSNP
rs938716995 1249 dbSNP
rs994352623 1269 dbSNP
rs1358825030 1288 dbSNP
rs1282202274 1300 dbSNP
rs1025291796 1302 dbSNP
rs1210516594 1311 dbSNP
rs1377372050 1326 dbSNP
rs1333227613 1329 dbSNP
rs1277880344 1362 dbSNP
rs1353378474 1369 dbSNP
rs1486555704 1373 dbSNP
rs1406726581 1384 dbSNP
rs1411104703 1387 dbSNP
rs1162540292 1418 dbSNP
rs1444353054 1450 dbSNP
rs775657582 1451 dbSNP
rs952495244 1460 dbSNP
rs747056706 1490 dbSNP
rs184817601 1509 dbSNP
rs984972755 1513 dbSNP
rs1232372688 1525 dbSNP
rs1222483672 1528 dbSNP
rs1453418981 1537 dbSNP
rs1289781452 1544 dbSNP
rs1245547586 1568 dbSNP
rs1354119341 1579 dbSNP
rs993341705 1582 dbSNP
rs1237858721 1583 dbSNP
rs1372594594 1589 dbSNP
rs1416734178 1600 dbSNP
rs1016472708 1612 dbSNP
rs189593006 1621 dbSNP
rs1302090478 1625 dbSNP
rs1380453619 1625 dbSNP
rs768626758 1626 dbSNP
rs1361538613 1639 dbSNP
rs192012553 1645 dbSNP
rs1160895004 1651 dbSNP
rs1453393480 1655 dbSNP
rs1171418342 1696 dbSNP
rs1407824753 1698 dbSNP
rs1192290696 1712 dbSNP
rs1373976480 1714 dbSNP
rs2038284 1721 dbSNP
rs949477396 1735 dbSNP
rs1221980584 1743 dbSNP
rs1303870154 1747 dbSNP
rs1488776205 1748 dbSNP
rs1287871689 1752 dbSNP
rs1213315464 1755 dbSNP
rs1396425734 1763 dbSNP
rs1316124116 1766 dbSNP
rs1301843614 1771 dbSNP
rs1220897846 1772 dbSNP
rs748081012 1774 dbSNP
rs1330970363 1778 dbSNP
rs1377790344 1780 dbSNP
rs1282135433 1781 dbSNP
rs1400224346 1799 dbSNP
rs923937902 1802 dbSNP
rs184613903 1804 dbSNP
rs769543774 1813 dbSNP
rs766225328 1816 dbSNP
rs1349705108 1835 dbSNP
rs1233725965 1837 dbSNP
rs189663605 1840 dbSNP
rs889707500 1867 dbSNP
rs768801926 1876 dbSNP
rs1197527368 1882 dbSNP
rs1198857403 1899 dbSNP
rs1478196851 1901 dbSNP
rs1238229050 1912 dbSNP
rs942628137 1918 dbSNP
rs1265524573 1923 dbSNP
rs1017200266 1925 dbSNP
rs1485393069 1927 dbSNP
rs1256420517 1937 dbSNP
rs41305421 1944 dbSNP
rs901026617 1961 dbSNP
rs993901723 1965 dbSNP
rs770512954 1993 dbSNP
rs1218656183 1996 dbSNP
rs1319398494 1997 dbSNP
rs773878928 1997 dbSNP
rs765166061 1998 dbSNP
rs888073314 1998 dbSNP
rs1191317521 2010 dbSNP
rs1303858647 2011 dbSNP
rs901614447 2034 dbSNP
rs199906454 2038 dbSNP
rs757928340 2049 dbSNP
rs1176342674 2060 dbSNP
rs1466170560 2063 dbSNP
rs777481620 2068 dbSNP
rs1425899024 2074 dbSNP
rs1435215254 2093 dbSNP
rs1428185623 2097 dbSNP
rs759047589 2112 dbSNP
rs1183441597 2117 dbSNP
rs12856294 2123 dbSNP
rs1459827054 2141 dbSNP
rs1034008435 2150 dbSNP
rs1372932121 2164 dbSNP
rs1460888081 2169 dbSNP
rs758280020 2170 dbSNP
rs1319327892 2182 dbSNP
rs1249152293 2192 dbSNP
rs1226230802 2206 dbSNP
rs1322006388 2208 dbSNP
rs1314443667 2230 dbSNP
rs1248538447 2238 dbSNP
rs766958527 2238 dbSNP
rs181311149 2240 dbSNP
rs971318871 2247 dbSNP
rs2038285 2250 dbSNP
rs762451818 2257 dbSNP
rs1296593242 2265 dbSNP
rs1461659635 2272 dbSNP
rs1369213288 2276 dbSNP
rs1167184126 2278 dbSNP
rs958150826 2306 dbSNP
rs765694949 2308 dbSNP
rs781648242 2309 dbSNP
rs1324073814 2316 dbSNP
rs1384405202 2343 dbSNP
rs956445740 2348 dbSNP
rs1459086970 2373 dbSNP
rs990328107 2375 dbSNP
rs1022295639 2388 dbSNP
rs1488522449 2398 dbSNP
rs911254960 2400 dbSNP
rs144933884 2401 dbSNP
rs980109344 2406 dbSNP
rs1387632514 2407 dbSNP
rs1041378856 2409 dbSNP
rs928646489 2420 dbSNP
rs1294548800 2421 dbSNP
rs922426199 2421 dbSNP
rs1305602763 2423 dbSNP
rs929800934 2426 dbSNP
rs868239904 2427 dbSNP
rs1391590363 2428 dbSNP
rs1305138159 2447 dbSNP
rs1229456856 2461 dbSNP
rs1423031539 2464 dbSNP
rs1364725515 2471 dbSNP
rs1258666331 2473 dbSNP
rs1441324726 2475 dbSNP
rs888189640 2477 dbSNP
rs750877923 2485 dbSNP
rs1433214267 2498 dbSNP
rs1268902745 2515 dbSNP
rs138175352 2519 dbSNP
rs929137807 2524 dbSNP
rs1332613356 2538 dbSNP
rs1048848746 2542 dbSNP
rs1217730998 2544 dbSNP
rs1185610548 2555 dbSNP
rs1353295082 2557 dbSNP
rs562480589 2559 dbSNP
rs1012470544 2560 dbSNP
rs1025657184 2561 dbSNP
rs1331734948 2564 dbSNP
rs1038915274 2587 dbSNP
rs749676942 2587 dbSNP
rs1345054405 2606 dbSNP
rs901542478 2609 dbSNP
rs1424992423 2610 dbSNP
rs997191567 2626 dbSNP
rs970882756 2649 dbSNP
rs1466523524 2650 dbSNP
rs1430779904 2663 dbSNP
rs891511377 2664 dbSNP
rs1012175325 2673 dbSNP
rs1263372665 2697 dbSNP
rs1000102612 2704 dbSNP
rs1162877231 2710 dbSNP
rs1260147384 2724 dbSNP
rs1021765317 2729 dbSNP
rs574077720 2735 dbSNP
rs970198060 2741 dbSNP
rs1265554808 2768 dbSNP
rs768694444 2769 dbSNP
rs1359556809 2777 dbSNP
rs1383711036 2778 dbSNP
rs1278698790 2779 dbSNP
rs1354724752 2780 dbSNP
rs1231447866 2781 dbSNP
rs1322953951 2782 dbSNP
rs1274469341 2784 dbSNP
rs1279018332 2793 dbSNP
rs1321844629 2813 dbSNP
rs774705155 2858 dbSNP
rs1035940647 2859 dbSNP
rs1317458837 2860 dbSNP
rs1031211658 2863 dbSNP
rs958096676 2874 dbSNP
rs761789316 2878 dbSNP
rs772245254 2883 dbSNP
rs1408136572 2885 dbSNP
rs1485066376 2890 dbSNP
rs1174191681 2914 dbSNP
rs989588289 2930 dbSNP
rs758851463 2931 dbSNP
rs1196287797 2937 dbSNP
rs1264435146 2938 dbSNP
rs1475151288 2950 dbSNP
rs960062759 2967 dbSNP
rs1240718104 2974 dbSNP
rs1192846127 2976 dbSNP
rs1462047320 2995 dbSNP
rs1245462401 2996 dbSNP
rs972724559 2999 dbSNP
rs766559527 3006 dbSNP
rs1460909729 3009 dbSNP
rs1258841911 3017 dbSNP
rs1216542772 3018 dbSNP
rs911204020 3024 dbSNP
rs1186490231 3032 dbSNP
rs186751976 3036 dbSNP
rs976656232 3043 dbSNP
rs922507752 3049 dbSNP
rs776682117 3067 dbSNP
rs1406058466 3070 dbSNP
rs759495129 3071 dbSNP
rs1451891837 3075 dbSNP
rs1343665179 3082 dbSNP
rs751749036 3084 dbSNP
rs1330389234 3087 dbSNP
rs1421812498 3093 dbSNP
rs1418261959 3102 dbSNP
rs1445562136 3106 dbSNP
rs909740430 3106 dbSNP
rs1387526588 3112 dbSNP
rs909080133 3116 dbSNP
rs941088996 3117 dbSNP
rs765276307 3124 dbSNP
rs189087787 3127 dbSNP
rs1298576982 3128 dbSNP
rs1055480838 3144 dbSNP
rs894112675 3145 dbSNP
rs1014341734 3154 dbSNP
rs1436157245 3170 dbSNP
rs1272513985 3172 dbSNP
rs1295074789 3174 dbSNP
rs1361306700 3185 dbSNP
rs762869741 3207 dbSNP
rs1245151495 3218 dbSNP
rs1377635638 3219 dbSNP
rs763639095 3220 dbSNP
rs1052761273 3243 dbSNP
rs867065004 3247 dbSNP
rs1353435609 3248 dbSNP
rs1045443173 3255 dbSNP
rs751395313 3266 dbSNP
rs906773116 3278 dbSNP
rs781167361 3280 dbSNP
rs999810986 3292 dbSNP
rs1031157693 3295 dbSNP
rs748070294 3298 dbSNP
rs893997580 3301 dbSNP
rs1222722795 3306 dbSNP
rs1444411350 3311 dbSNP
rs891550908 3312 dbSNP
rs1179495411 3314 dbSNP
rs1468624818 3317 dbSNP
rs1010968261 3322 dbSNP
rs1318353952 3325 dbSNP
rs1011351891 3335 dbSNP
rs1490922544 3354 dbSNP
rs1042807540 3355 dbSNP
rs906069170 3363 dbSNP
rs1287165720 3375 dbSNP
rs1317326067 3376 dbSNP
rs1286197626 3387 dbSNP
rs751273865 3397 dbSNP
rs1209308164 3403 dbSNP
rs1406379904 3406 dbSNP
rs1343190744 3415 dbSNP
rs964200166 3436 dbSNP
rs1239730980 3438 dbSNP
rs977149955 3443 dbSNP
rs762023265 3444 dbSNP
rs756100676 3455 dbSNP
rs181032563 3456 dbSNP
rs780638627 3473 dbSNP
rs1161887604 3475 dbSNP
rs1399509896 3481 dbSNP
rs1025617267 3482 dbSNP
rs1176674206 3482 dbSNP
rs1177321805 3482 dbSNP
rs749959165 3483 dbSNP
rs951354308 3488 dbSNP
rs1198990621 3491 dbSNP
rs756558335 3503 dbSNP
rs1441742631 3505 dbSNP
rs982680453 3506 dbSNP
rs1213551489 3509 dbSNP
rs749016496 3514 dbSNP
rs1316325599 3519 dbSNP
rs1159525843 3526 dbSNP
rs1263693920 3527 dbSNP
rs909688189 3536 dbSNP
rs770743766 3540 dbSNP
rs1224741508 3548 dbSNP
rs941204617 3549 dbSNP
rs911306514 3566 dbSNP
rs1282191922 3595 dbSNP
rs991161916 3599 dbSNP
rs1363058270 3600 dbSNP
rs780544288 3603 dbSNP
rs749612462 3606 dbSNP
rs1432661285 3624 dbSNP
rs964550601 3625 dbSNP
rs974515796 3626 dbSNP
rs1337991867 3632 dbSNP
rs1470966621 3634 dbSNP
rs1359661343 3636 dbSNP
rs1441474929 3641 dbSNP
rs769126918 3642 dbSNP
rs915660716 3646 dbSNP
rs1378540907 3653 dbSNP
rs949866964 3656 dbSNP
rs933222231 3662 dbSNP
rs186127769 3670 dbSNP
rs1045800239 3676 dbSNP
rs1232571571 3681 dbSNP
rs1243638374 3687 dbSNP
rs769942005 3692 dbSNP
rs778984501 3701 dbSNP
rs774007193 3713 dbSNP
rs1262010287 3732 dbSNP
rs1053430993 3744 dbSNP
rs1364948139 3744 dbSNP
rs1455090017 3744 dbSNP
rs759383063 3744 dbSNP
rs947037486 3744 dbSNP
rs1403992470 3747 dbSNP
rs1443492606 3749 dbSNP
rs902872460 3753 dbSNP
rs1356429912 3764 dbSNP
rs1204488241 3767 dbSNP
rs748445770 3775 dbSNP
rs1185316935 3787 dbSNP
rs1001705558 3790 dbSNP
rs1241977026 3794 dbSNP
rs1052702145 3796 dbSNP
rs772457439 3801 dbSNP
rs893938908 3803 dbSNP
rs1203432263 3804 dbSNP
rs1341855038 3807 dbSNP
rs1316250518 3827 dbSNP
rs1248785689 3829 dbSNP
rs896070482 3839 dbSNP
rs1312641151 3841 dbSNP
rs1452873890 3855 dbSNP
rs994458622 3876 dbSNP
rs773365184 3878 dbSNP
rs1429396008 3880 dbSNP
rs1026298737 3882 dbSNP
rs1165304576 3901 dbSNP
rs1011074760 3904 dbSNP
rs1384465795 3916 dbSNP
rs1018485822 3926 dbSNP
rs1420326809 3929 dbSNP
rs899899603 3945 dbSNP
rs964060082 3950 dbSNP
rs974559868 3965 dbSNP
rs1293507198 3970 dbSNP
rs35615566 3971 dbSNP
rs998304142 3973 dbSNP
rs1357780117 3991 dbSNP
rs1030053318 3994 dbSNP
rs951425395 4003 dbSNP
rs982628209 4004 dbSNP
rs1016809757 4008 dbSNP
rs965539330 4033 dbSNP
rs1305045136 4036 dbSNP
rs913131546 4045 dbSNP
rs1346329021 4054 dbSNP
rs1305196836 4069 dbSNP
rs1402834832 4077 dbSNP
rs1389802422 4079 dbSNP
rs1159040874 4088 dbSNP
rs962642906 4096 dbSNP
rs947079663 4105 dbSNP
rs1200025106 4115 dbSNP
rs1361543451 4119 dbSNP
rs745557094 4122 dbSNP
rs144266821 4123 dbSNP
rs774748356 4124 dbSNP
rs1042705404 4144 dbSNP
rs1489955677 4154 dbSNP
rs1267155042 4166 dbSNP
rs1206236604 4177 dbSNP
rs1438250875 4181 dbSNP
rs1259502153 4184 dbSNP
rs1276941558 4191 dbSNP
rs1324410646 4191 dbSNP
rs949823559 4191 dbSNP
rs927047316 4194 dbSNP
rs1221953498 4197 dbSNP
rs1330293036 4215 dbSNP
rs148330089 4216 dbSNP
rs762632903 4226 dbSNP
rs1383718093 4230 dbSNP
rs1382608905 4246 dbSNP
rs1319844334 4250 dbSNP
rs57087998 4251 dbSNP
rs1056888927 4271 dbSNP
rs1173775086 4277 dbSNP
rs934352457 4280 dbSNP
rs1251381063 4287 dbSNP
rs930134555 4291 dbSNP
rs1320006177 4295 dbSNP
rs751339933 4297 dbSNP
rs1260214987 4311 dbSNP
rs1208679415 4343 dbSNP
rs761477098 4358 dbSNP
rs1265146283 4370 dbSNP
rs767171619 4371 dbSNP
rs1054160732 4375 dbSNP
rs1221894487 4379 dbSNP
rs894053174 4380 dbSNP
rs1199361054 4398 dbSNP
rs749869034 4401 dbSNP
rs946978967 4403 dbSNP
rs1270993171 4408 dbSNP
rs1252530628 4412 dbSNP
rs866557543 4418 dbSNP
rs1467288262 4459 dbSNP
rs1201346658 4462 dbSNP
rs5964981 4465 dbSNP
rs900015791 4470 dbSNP
rs1453337912 4473 dbSNP
rs1474979006 4482 dbSNP
rs762399011 4486 dbSNP
rs1334190461 4487 dbSNP
rs1184640469 4499 dbSNP
rs765784533 4507 dbSNP
rs1396689811 4513 dbSNP
rs1169320181 4519 dbSNP
rs1476568555 4520 dbSNP
rs1388763476 4521 dbSNP
rs1188477805 4526 dbSNP
rs1445824892 4541 dbSNP
rs1466130541 4543 dbSNP
rs1163576346 4545 dbSNP
rs1051195615 4546 dbSNP
rs888664047 4551 dbSNP
rs1441945799 4569 dbSNP
rs1273916366 4591 dbSNP
rs1197826335 4593 dbSNP
rs7890060 4599 dbSNP
rs773864141 4611 dbSNP
rs887067963 4613 dbSNP
rs1005513893 4622 dbSNP
rs1018208604 4623 dbSNP
rs1384833520 4629 dbSNP
rs1312843072 4631 dbSNP
rs1335860040 4645 dbSNP
rs1446604941 4645 dbSNP
rs763441186 4659 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions TZM-bl
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM1462573. RNA binding protein: AGO2. Condition:TZM-bl BaL PAR-CLIP data was present in GSM1462574. RNA binding protein: AGO2. Condition:TZM-bl ami BaL ...

- Whisnant AW; Bogerd HP; Flores O; Ho P; et al., 2013, mBio.

Article - Whisnant AW; Bogerd HP; Flores O; Ho P; et al.
- mBio, 2013
UNLABELLED: The question of how HIV-1 interfaces with cellular microRNA (miRNA) biogenesis and effector mechanisms has been highly controversial. Here, we first used deep sequencing of small RNAs present in two different infected cell lines (TZM-bl and C8166) and two types of primary human cells (CD4(+) peripheral blood mononuclear cells [PBMCs] and macrophages) to unequivocally demonstrate that HIV-1 does not encode any viral miRNAs. Perhaps surprisingly, we also observed that infection of T cells by HIV-1 has only a modest effect on the expression of cellular miRNAs at early times after infection. Comprehensive analysis of miRNA binding to the HIV-1 genome using the photoactivatable ribonucleoside-induced cross-linking and immunoprecipitation (PAR-CLIP) technique revealed several binding sites for cellular miRNAs, a subset of which were shown to be capable of mediating miRNA-mediated repression of gene expression. However, the main finding from this analysis is that HIV-1 transcripts are largely refractory to miRNA binding, most probably due to extensive viral RNA secondary structure. Together, these data demonstrate that HIV-1 neither encodes viral miRNAs nor strongly influences cellular miRNA expression, at least early after infection, and imply that HIV-1 transcripts have evolved to avoid inhibition by preexisting cellular miRNAs by adopting extensive RNA secondary structures that occlude most potential miRNA binding sites. IMPORTANCE: MicroRNAs (miRNAs) are a ubiquitous class of small regulatory RNAs that serve as posttranscriptional regulators of gene expression. Previous work has suggested that HIV-1 might subvert the function of the cellular miRNA machinery by expressing viral miRNAs or by dramatically altering the level of cellular miRNA expression. Using very sensitive approaches, we now demonstrate that neither of these ideas is in fact correct. Moreover, HIV-1 transcripts appear to largely avoid regulation by cellular miRNAs by adopting an extensive RNA secondary structure that occludes the ability of cellular miRNAs to interact with viral mRNAs. Together, these data suggest that HIV-1, rather than seeking to control miRNA function in infected cells, has instead evolved a mechanism to become largely invisible to cellular miRNA effector mechanisms.
LinkOut: [PMID: 23592263]
Experimental Support 2 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions MCF7
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in SRR1045082. RNA binding protein: AGO2. Condition:Untreated ...

- Farazi TA; Ten Hoeve JJ; Brown M; et al., 2014, Genome biology.

Article - Farazi TA; Ten Hoeve JJ; Brown M; et al.
- Genome biology, 2014
BACKGROUND: Various microRNAs (miRNAs) are up- or downregulated in tumors. However, the repression of cognate miRNA targets responsible for the phenotypic effects of this dysregulation in patients remains largely unexplored. To define miRNA targets and associated pathways, together with their relationship to outcome in breast cancer, we integrated patient-paired miRNA-mRNA expression data with a set of validated miRNA targets and pathway inference. RESULTS: To generate a biochemically-validated set of miRNA-binding sites, we performed argonaute-2 photoactivatable-ribonucleoside-enhanced crosslinking and immunoprecipitation (AGO2-PAR-CLIP) in MCF7 cells. We then defined putative miRNA-target interactions using a computational model, which ranked and selected additional TargetScan-predicted interactions based on features of our AGO2-PAR-CLIP binding-site data. We subselected modeled interactions according to the abundance of their constituent miRNA and mRNA transcripts in tumors, and we took advantage of the variability of miRNA expression within molecular subtypes to detect miRNA repression. Interestingly, our data suggest that miRNA families control subtype-specific pathways; for example, miR-17, miR-19a, miR-25, and miR-200b show high miRNA regulatory activity in the triple-negative, basal-like subtype, whereas miR-22 and miR-24 do so in the HER2 subtype. An independent dataset validated our findings for miR-17 and miR-25, and showed a correlation between the expression levels of miR-182 targets and overall patient survival. Pathway analysis associated miR-17, miR-19a, and miR-200b with leukocyte transendothelial migration. CONCLUSIONS: We combined PAR-CLIP data with patient expression data to predict regulatory miRNAs, revealing potential therapeutic targets and prognostic markers in breast cancer.
LinkOut: [PMID: 24398324]
Experimental Support 3 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions Prostate Tissue
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in SRX1760618. RNA binding protein: AGO2. Condition:AGO-CLIP-PC3_B PAR-CLIP data was present in SRX1760616. RNA binding protein: AGO2. Condition:AGO-CLIP-PC3_A PAR-CLIP data was present in SRX1760631. RNA binding protein: AGO2. Condition:AGO-CLIP-22RV1_B ...

- Hamilton MP; Rajapakshe KI; Bader DA; Cerne et al., 2016, Neoplasia (New York, N.Y.).

Article - Hamilton MP; Rajapakshe KI; Bader DA; Cerne et al.
- Neoplasia (New York, N.Y.), 2016
MicroRNA (miRNA) deregulation in prostate cancer (PCa) contributes to PCa initiation and metastatic progression. To comprehensively define the cancer-associated changes in miRNA targeting and function in commonly studied models of PCa, we performed photoactivatable ribonucleoside-enhanced cross-linking immunoprecipitation of the Argonaute protein in a panel of PCa cell lines modeling different stages of PCa progression. Using this comprehensive catalogue of miRNA targets, we analyzed miRNA targeting on known drivers of PCa and examined tissue-specific and stage-specific pathway targeting by miRNAs. We found that androgen receptor is the most frequently targeted PCa oncogene and that miR-148a targets the largest number of known PCa drivers. Globally, tissue-specific and stage-specific changes in miRNA targeting are driven by homeostatic response to active oncogenic pathways. Our findings indicate that, even in advanced PCa, the miRNA pool adapts to regulate continuing alterations in the cancer genome to balance oncogenic molecular changes. These findings are important because they are the first to globally characterize miRNA changes in PCa and demonstrate how the miRNA target spectrum responds to staged tumorigenesis.
LinkOut: [PMID: 27292025]
CLIP-seq Support 1 for dataset SRR1045082
Method / RBP PAR-CLIP / AGO2
Cell line / Condition MCF7 / Untreated
Location of target site ENST00000338957.4 | 3UTR | CCCUCUCUCUCUCUCUCUCUGCCC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 24398324 / SRX388831
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM1462573
Method / RBP PAR-CLIP / AGO2
Cell line / Condition TZM-bl / TZM-bl BaL
Location of target site ENST00000338957.4 | 3UTR | CUCUCUCCCUCUCUCUCUCUCUCUCUGCCC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23592263 / GSE59944
CLIP-seq Viewer Link
CLIP-seq Support 3 for dataset GSM1462574
Method / RBP PAR-CLIP / AGO2
Cell line / Condition TZM-bl / TZM-bl ami BaL
Location of target site ENST00000338957.4 | 3UTR | CCCUCUCUCUCUCUCUCUCUGCCC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23592263 / GSE59944
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
121 hsa-miR-4651 Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT066212 MARCH9 membrane associated ring-CH-type finger 9 2 2
MIRT113270 TMBIM6 transmembrane BAX inhibitor motif containing 6 2 2
MIRT115795 CAPN15 calpain 15 2 2
MIRT125296 MID1IP1 MID1 interacting protein 1 2 2
MIRT145419 ANKRD13B ankyrin repeat domain 13B 2 2
MIRT153779 NCOA3 nuclear receptor coactivator 3 2 2
MIRT189384 TXLNA taxilin alpha 2 4
MIRT451063 PNMAL2 paraneoplastic Ma antigen family member 8B 2 2
MIRT451142 C19orf53 chromosome 19 open reading frame 53 2 2
MIRT452374 LY6E lymphocyte antigen 6 family member E 2 4
MIRT452788 FAM136A family with sequence similarity 136 member A 2 2
MIRT452985 CABP4 calcium binding protein 4 2 2
MIRT453231 FTSJ3 FtsJ RNA methyltransferase homolog 3 2 2
MIRT453824 SAA1 serum amyloid A1 2 2
MIRT454136 FOXRED2 FAD dependent oxidoreductase domain containing 2 2 2
MIRT455104 NKX2-2 NK2 homeobox 2 2 6
MIRT455250 DDX39B DExD-box helicase 39B 2 10
MIRT456899 DDA1 DET1 and DDB1 associated 1 2 2
MIRT457099 DCX doublecortin 2 2
MIRT457761 ZC3H12B zinc finger CCCH-type containing 12B 2 4
MIRT458539 CYP2B6 cytochrome P450 family 2 subfamily B member 6 2 2
MIRT459011 UQCRH ubiquinol-cytochrome c reductase hinge protein 2 2
MIRT459197 RCE1 Ras converting CAAX endopeptidase 1 2 2
MIRT459295 PHYKPL 5-phosphohydroxy-L-lysine phospho-lyase 2 2
MIRT459466 MUC17 mucin 17, cell surface associated 2 4
MIRT459598 KCNK3 potassium two pore domain channel subfamily K member 3 2 2
MIRT461274 COX10 COX10, heme A:farnesyltransferase cytochrome c oxidase assembly factor 2 2
MIRT464551 UBTF upstream binding transcription factor, RNA polymerase I 2 2
MIRT465253 TRIM44 tripartite motif containing 44 2 2
MIRT465274 TRIM28 tripartite motif containing 28 2 2
MIRT465402 TP53 tumor protein p53 2 2
MIRT465877 TMEM43 transmembrane protein 43 2 4
MIRT466234 TMED10 transmembrane p24 trafficking protein 10 2 2
MIRT467027 SRSF1 serine and arginine rich splicing factor 1 2 4
MIRT468320 SF3B3 splicing factor 3b subunit 3 2 2
MIRT468437 SETD1B SET domain containing 1B 2 2
MIRT468691 SEC22C SEC22 homolog C, vesicle trafficking protein 2 4
MIRT468863 RREB1 ras responsive element binding protein 1 2 2
MIRT469779 RAB15 RAB15, member RAS oncogene family 2 2
MIRT470314 PPP6R1 protein phosphatase 6 regulatory subunit 1 2 2
MIRT470765 PNPLA6 patatin like phospholipase domain containing 6 2 2
MIRT472213 NGFR nerve growth factor receptor 2 2
MIRT472520 NACC1 nucleus accumbens associated 1 2 2
MIRT473281 MFRP membrane frizzled-related protein 2 2
MIRT473403 MDM4 MDM4, p53 regulator 2 2
MIRT473521 MAX MYC associated factor X 2 2
MIRT474529 KLHDC8A kelch domain containing 8A 2 2
MIRT474631 KLF16 Kruppel like factor 16 2 2
MIRT475130 IP6K1 inositol hexakisphosphate kinase 1 2 2
MIRT475808 HDGF heparin binding growth factor 2 2
MIRT478623 CTDNEP1 CTD nuclear envelope phosphatase 1 2 2
MIRT479501 CDH6 cadherin 6 2 2
MIRT479865 CCDC6 coiled-coil domain containing 6 2 2
MIRT480132 CALR calreticulin 2 2
MIRT480529 C10orf76 chromosome 10 open reading frame 76 2 2
MIRT480774 BMP2 bone morphogenetic protein 2 2 2
MIRT481423 ASB6 ankyrin repeat and SOCS box containing 6 2 2
MIRT481778 APEX1 apurinic/apyrimidinic endodeoxyribonuclease 1 2 2
MIRT481821 AP2M1 adaptor related protein complex 2 mu 1 subunit 2 2
MIRT482698 XRCC3 X-ray repair cross complementing 3 2 2
MIRT482976 CSTF2 cleavage stimulation factor subunit 2 2 2
MIRT483391 SPATA6 spermatogenesis associated 6 2 4
MIRT483429 RHOXF2B Rhox homeobox family member 2B 2 2
MIRT483476 STMN3 stathmin 3 2 4
MIRT483687 CYP11A1 cytochrome P450 family 11 subfamily A member 1 2 2
MIRT483803 CYP2W1 cytochrome P450 family 2 subfamily W member 1 2 6
MIRT484335 EPN1 epsin 1 2 4
MIRT484683 PACSIN1 protein kinase C and casein kinase substrate in neurons 1 2 2
MIRT484966 UCK1 uridine-cytidine kinase 1 2 2
MIRT485987 YIPF2 Yip1 domain family member 2 2 2
MIRT486773 SESTD1 SEC14 and spectrin domain containing 1 2 4
MIRT487372 C10orf54 V-set immunoregulatory receptor 2 2
MIRT487632 ONECUT3 one cut homeobox 3 2 4
MIRT488080 DLGAP3 DLG associated protein 3 2 4
MIRT488158 PRRC2B proline rich coiled-coil 2B 2 4
MIRT488463 B3GALNT2 beta-1,3-N-acetylgalactosaminyltransferase 2 2 2
MIRT490948 PPM1F protein phosphatase, Mg2+/Mn2+ dependent 1F 2 2
MIRT491719 RTN4R reticulon 4 receptor 2 2
MIRT492338 SEPT8 septin 8 2 2
MIRT493038 NAA50 N(alpha)-acetyltransferase 50, NatE catalytic subunit 2 2
MIRT493368 KIAA1614 KIAA1614 2 2
MIRT499384 PLCG2 phospholipase C gamma 2 2 11
MIRT499596 ANKRD45 ankyrin repeat domain 45 2 2
MIRT499730 USH1G USH1 protein network component sans 2 4
MIRT500357 ZNF385A zinc finger protein 385A 2 2
MIRT501691 PCGF3 polycomb group ring finger 3 2 6
MIRT504502 PPP1R9B protein phosphatase 1 regulatory subunit 9B 2 2
MIRT509579 HIST2H2AB histone cluster 2 H2A family member b 2 4
MIRT510610 TPM3 tropomyosin 3 2 2
MIRT512803 GLRX glutaredoxin 2 2
MIRT513302 SETBP1 SET binding protein 1 2 2
MIRT514005 CECR2 CECR2, histone acetyl-lysine reader 2 4
MIRT515701 ZNF321P zinc finger protein 321, pseudogene 2 2
MIRT518260 LEAP2 liver enriched antimicrobial peptide 2 2 2
MIRT523183 HIST3H3 histone cluster 3 H3 2 2
MIRT524051 DNAJC8 DnaJ heat shock protein family (Hsp40) member C8 2 2
MIRT538642 CCSAP centriole, cilia and spindle associated protein 2 2
MIRT541497 ADM adrenomedullin 2 2
MIRT569279 PTPRF protein tyrosine phosphatase, receptor type F 2 2
MIRT570279 ARPC3 actin related protein 2/3 complex subunit 3 2 2
MIRT570326 ZBTB7A zinc finger and BTB domain containing 7A 2 2
MIRT571451 YKT6 YKT6 v-SNARE homolog 2 2
MIRT571597 TOB2 transducer of ERBB2, 2 2 2
MIRT574894 Plcg2 phospholipase C, gamma 2 2 7
MIRT607551 GLI2 GLI family zinc finger 2 2 2
MIRT607694 MAPK10 mitogen-activated protein kinase 10 2 2
MIRT609983 PPARA peroxisome proliferator activated receptor alpha 2 2
MIRT610076 CRLF1 cytokine receptor like factor 1 2 2
MIRT610578 CACUL1 CDK2 associated cullin domain 1 2 4
MIRT626322 LRTOMT leucine rich transmembrane and O-methyltransferase domain containing 2 2
MIRT634011 RIF1 replication timing regulatory factor 1 2 2
MIRT642680 KRT74 keratin 74 2 2
MIRT689717 ATXN2 ataxin 2 2 2
MIRT691175 APOL6 apolipoprotein L6 2 2
MIRT693169 NPR1 natriuretic peptide receptor 1 2 2
MIRT697121 OTUD5 OTU deubiquitinase 5 2 2
MIRT711817 ELN elastin 2 2
MIRT721551 FXN frataxin 2 2
MIRT721666 SLFN12 schlafen family member 12 2 2
MIRT723760 NKIRAS2 NFKB inhibitor interacting Ras like 2 2 2
MIRT737362 FOXP4 forkhead box P4 2 0
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-4 Dexamethasone approved 5743 Microarray primary rat thymocytes 20847043 2010 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-4651 Platinum 23939 sensitive High Ovarian Cancer tissue
hsa-miR-4651 Imatinib 5291 NSC743414 approved sensitive High Gastrointestinal Stromal Tumor cell line (882R-NC, 882R-OE, 882R-KD)
hsa-miR-4651 Cisplatin 5460033 NSC119875 approved resistant High Pancreatic Cancer cell line (BxPC-3)
hsa-miR-4651 Dabrafenib 44462760 NSC764134 approved resistant High Melanoma cell line (A375, IGR37, 501Mel)
hsa-miR-4651 Vemurafenib 42611257 NSC761431 approved resistant High Melanoma cell line (A375, IGR37, 501Mel)
hsa-miR-4651 Curcumin 969516 NSC32982 approved sensitive High Breast Cancer cell line (MCF-7)
hsa-miR-4651 Doxorubicin 31703 NSC123127 approved sensitive High Breast Cancer cell line (MCF-7)
hsa-miR-4651 Paclitaxel 36314 NSC125973 approved resistant High Non-Small Cell Lung Cancer cell line (A549)
hsa-miR-4651 Fulvestrant 17756771 NSC719276 approved resistant High Breast Cancer cell line (MCF-7)
hsa-mir-4651 Dabrafenib 44462760 NSC764134 approved resistant cell line (A375)
hsa-mir-4651 Cisplatin 5460033 NSC119875 approved resistant cell line (BxPC3)
hsa-miR-4651 Osimertinib 71496458 NSC779217 approved resistant cell line (PC9)
hsa-miR-4651 Cisplatin 5460033 NSC119875 approved resistant cell line (CAL-27) (cytosolic RNA)
hsa-miR-4651 Cisplatin 5460033 NSC119875 approved resistant cell line (CAL-27) (total RNA)
hsa-miR-4651 Cisplatin 5460033 NSC119875 approved sensitive cell line
hsa-miR-4651 Doxorubicin 31703 NSC123127 approved resistant cell line (HS578T)
hsa-miR-4651 Doxorubicin 31703 NSC123127 approved resistant cell line (BAS)
hsa-miR-4651 Cisplatin 5460033 NSC119875 approved resistant cell line (CIS)
hsa-miR-4651 Cisplatin 5460033 NSC119875 approved resistant cell line (CP20)
hsa-miR-4651 Osimertinib 71496458 NSC779217 approved sensitive cell line (H1975)
hsa-miR-4651 Vemurafenib 42611257 NSC761431 approved sensitive cell line (LM16)
hsa-miR-4651 Neoadjuvant chemotherapy sensitive tissue (breast cancer)
hsa-miR-4651 Neoadjuvant chemotherapy sensitive tissue (breast cancer)
hsa-miR-4651 Gemcitabine 60750 NSC613327 approved resistant cell line (PANC-1) (1500 ng/ml)
hsa-miR-4651 Gemcitabine 60750 NSC613327 approved resistant cell line (PANC-1) (100 ng/ml)
hsa-miR-4651 Gemcitabine 60750 NSC613327 approved resistant cell line (Panc1-GR4)

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