pre-miRNA Information
pre-miRNA hsa-mir-3179-1   
Genomic Coordinates chr16: 14901508 - 14901591
Description Homo sapiens miR-3179-1 stem-loop
Comment None
RNA Secondary Structure
Associated Diseases
pre-miRNA hsa-mir-3179-2   
Genomic Coordinates chr16: 16300159 - 16300242
Description Homo sapiens miR-3179-2 stem-loop
Comment None
RNA Secondary Structure
Associated Diseases
pre-miRNA hsa-mir-3179-3   
Genomic Coordinates chr16: 18411894 - 18411977
Description Homo sapiens miR-3179-3 stem-loop
Comment None
RNA Secondary Structure
Associated Diseases
pre-miRNA hsa-mir-3179-4   
Genomic Coordinates chr16: 18494493 - 18494576
Description Homo sapiens miR-3179-4 stem-loop
Comment None
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-3179
Sequence 52| AGAAGGGGUGAAAUUUAAACGU |73
Evidence Experimental
Experiments Illumina
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1351100204 1 dbSNP
rs1398613616 4 dbSNP
rs1340262765 20 dbSNP
rs1229893475 21 dbSNP
Putative Targets

miRNA Expression profile
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol GPR35   
Synonyms -
Description G protein-coupled receptor 35
Transcript NM_005301   
Expression
Putative miRNA Targets on GPR35
3'UTR of GPR35
(miRNA target sites are highlighted)
>GPR35|NM_005301|3'UTR
   1 GAGGCGTGCTGTGGGCGCTGTGGGCCAGGTCTCGGGGGCTCCGGGAGGTGCTGCCTGCCAGGGGAAGCTGGAACCAGTAG
  81 CAAGGAGCCCGAGATCAGCCCTGAACTCACTGTGTATTCTCTTGGAGCCTTGGGTGGGCAGGGACGGCCCAGGTACCTGC
 161 TCTCTTGGGAAGAGAGAGGGACAGGGACAAGGGCAAGAGGACTGAGGCCAGAGCAAGGCCAATGTCAGAGACCCCCGGGA
 241 TGGGGCCTCACACTTGCCACCCCCAGAACCAGCTCACCTGGCCAGAGTGGGTTCCTGCTGGCCAGGGTGCAGCCTTGATG
 321 ACACCTGCCGCTGCCCCTCGGGGCTGGAATAAAACTCCCCACCCAGAGTCAGTCCTAAAAAAAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' ugcaaauuuaaaGUGGGGAaga 5'
                      ::|||||   
Target 5' gacacctgccgcTGCCCCTcgg 3'
320 - 341 102.00 -8.02
2
miRNA  3' ugcaAAUUUAAA--GUGGGGaaga 5'
              | | | ||  ||||||    
Target 5' ggccTCACACTTGCCACCCCcaga 3'
244 - 267 96.00 -9.76
3
miRNA  3' ugcaaauUUAAAG----UGGGGaaga 5'
                 ||| ||    |||||    
Target 5' caaggccAATGTCAGAGACCCCcggg 3'
214 - 239 93.00 -7.56
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN24400656 6 COSMIC
COSN13982955 17 COSMIC
COSN30137203 18 COSMIC
COSN30529194 29 COSMIC
COSN13982958 34 COSMIC
COSN13982959 35 COSMIC
COSN28194706 36 COSMIC
COSN30481614 37 COSMIC
COSN30522917 42 COSMIC
COSN26441454 43 COSMIC
COSN30532278 44 COSMIC
COSN30531854 50 COSMIC
COSN28827948 56 COSMIC
COSN30516915 59 COSMIC
COSN31506238 62 COSMIC
COSN30479880 65 COSMIC
COSN30477129 72 COSMIC
COSN17693172 81 COSMIC
COSN6681963 93 COSMIC
COSN30463946 94 COSMIC
COSN15624385 120 COSMIC
COSN30509480 130 COSMIC
COSN31518345 140 COSMIC
COSN31521752 179 COSMIC
COSN15624386 180 COSMIC
COSN31514120 224 COSMIC
COSN31483630 250 COSMIC
COSN15624387 263 COSMIC
COSN30174258 286 COSMIC
COSN15624388 295 COSMIC
COSN20715585 372 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs751886685 2 dbSNP
rs199706629 6 dbSNP
rs781236677 7 dbSNP
rs1339230270 8 dbSNP
rs1299266112 11 dbSNP
rs780325829 15 dbSNP
rs199553393 17 dbSNP
rs552670246 18 dbSNP
rs780346623 21 dbSNP
rs1429570440 23 dbSNP
rs1266315935 24 dbSNP
rs573808691 25 dbSNP
rs768727574 28 dbSNP
rs774146102 29 dbSNP
rs747927192 30 dbSNP
rs771942582 32 dbSNP
rs772719757 34 dbSNP
rs760379738 35 dbSNP
rs1188696384 36 dbSNP
rs779838005 39 dbSNP
rs375334362 40 dbSNP
rs1156400493 42 dbSNP
rs547386562 43 dbSNP
rs763397646 44 dbSNP
rs369873945 45 dbSNP
rs1213422653 47 dbSNP
rs1373539612 49 dbSNP
rs566004779 54 dbSNP
rs536151550 60 dbSNP
rs1371881514 61 dbSNP
rs1008946530 63 dbSNP
rs1339039704 65 dbSNP
rs1031015682 71 dbSNP
rs1406298921 72 dbSNP
rs945382496 88 dbSNP
rs554370200 91 dbSNP
rs1255377615 92 dbSNP
rs2975786 93 dbSNP
rs1418375346 95 dbSNP
rs936787477 104 dbSNP
rs1055602264 117 dbSNP
rs201998665 132 dbSNP
rs756686473 132 dbSNP
rs1010840366 139 dbSNP
rs1261371039 140 dbSNP
rs114392845 143 dbSNP
rs1167024628 144 dbSNP
rs969279860 146 dbSNP
rs558199503 147 dbSNP
rs1024235700 148 dbSNP
rs907077452 158 dbSNP
rs1430858288 160 dbSNP
rs1003901961 163 dbSNP
rs576763329 167 dbSNP
rs1015295144 168 dbSNP
rs1288877242 169 dbSNP
rs1034773545 171 dbSNP
rs1452469162 173 dbSNP
rs962351135 178 dbSNP
rs1165372269 182 dbSNP
rs35230312 183 dbSNP
rs982463175 185 dbSNP
rs908231623 190 dbSNP
rs1448897295 200 dbSNP
rs941001352 210 dbSNP
rs954243866 215 dbSNP
rs1487360004 218 dbSNP
rs973705008 222 dbSNP
rs987333146 226 dbSNP
rs1395959664 229 dbSNP
rs1223835824 232 dbSNP
rs1313986902 233 dbSNP
rs1341805982 235 dbSNP
rs920836892 237 dbSNP
rs552692498 238 dbSNP
rs912831925 240 dbSNP
rs1295879452 246 dbSNP
rs945603403 249 dbSNP
rs1050585467 250 dbSNP
rs890593877 251 dbSNP
rs151129330 260 dbSNP
rs1055251024 261 dbSNP
rs1161172253 271 dbSNP
rs1482772857 272 dbSNP
rs1476288191 273 dbSNP
rs1052494434 274 dbSNP
rs542145613 278 dbSNP
rs948586045 281 dbSNP
rs1045952548 308 dbSNP
rs1271132642 320 dbSNP
rs892491572 323 dbSNP
rs907019473 324 dbSNP
rs545096104 330 dbSNP
rs531099555 331 dbSNP
rs898195703 333 dbSNP
rs1340471550 339 dbSNP
rs546323503 340 dbSNP
rs116534085 341 dbSNP
rs1034826377 348 dbSNP
rs1405033511 359 dbSNP
rs528566949 362 dbSNP
rs1170644039 368 dbSNP
rs1357795548 369 dbSNP
rs1003938611 370 dbSNP
rs796950797 375 dbSNP
rs1464214785 377 dbSNP
rs1431728401 379 dbSNP
rs547017867 383 dbSNP
rs1020231698 386 dbSNP
rs1480166438 387 dbSNP
rs1245108597 394 dbSNP
rs1184563938 395 dbSNP
rs966832560 397 dbSNP
rs561913243 398 dbSNP
rs773515828 403 dbSNP
rs530038080 404 dbSNP
rs1365205541 411 dbSNP
rs953765422 419 dbSNP
rs762910399 428 dbSNP
rs912081740 429 dbSNP
rs1311459486 430 dbSNP
rs1233669010 431 dbSNP
rs991190980 436 dbSNP
rs944836371 437 dbSNP
rs2953156 438 dbSNP
rs1463508910 446 dbSNP
rs913969173 448 dbSNP
rs569534853 449 dbSNP
rs115519330 451 dbSNP
rs76429238 452 dbSNP
rs141100240 455 dbSNP
rs1002090891 459 dbSNP
rs1036957250 461 dbSNP
rs191878730 470 dbSNP
rs552969570 471 dbSNP
rs1462954482 474 dbSNP
rs1244179787 481 dbSNP
rs1433009397 492 dbSNP
rs574320459 497 dbSNP
rs1379683129 499 dbSNP
rs184263047 503 dbSNP
rs557640685 509 dbSNP
rs1351264027 511 dbSNP
rs1320404846 520 dbSNP
rs995200741 521 dbSNP
rs1237936532 523 dbSNP
rs1049832965 527 dbSNP
rs1337225931 536 dbSNP
rs896347346 537 dbSNP
rs1003989608 541 dbSNP
rs1291473934 546 dbSNP
rs1366446703 549 dbSNP
rs575920397 552 dbSNP
rs1407830612 565 dbSNP
rs1008417456 566 dbSNP
rs1447015191 572 dbSNP
rs1386241719 574 dbSNP
rs1303179843 578 dbSNP
rs962779582 592 dbSNP
rs763453884 593 dbSNP
rs1235415516 604 dbSNP
rs1217253683 608 dbSNP
rs1227720998 611 dbSNP
rs995232036 614 dbSNP
rs753391407 617 dbSNP
rs953712772 624 dbSNP
rs999616355 629 dbSNP
rs1214354392 630 dbSNP
rs1361576186 631 dbSNP
rs1315408577 636 dbSNP
rs1227534861 637 dbSNP
rs1032561268 639 dbSNP
rs1329998572 641 dbSNP
rs986403084 643 dbSNP
rs990851606 644 dbSNP
rs373877600 651 dbSNP
rs78486705 652 dbSNP
rs1366747447 658 dbSNP
rs565829284 658 dbSNP
rs1164471761 660 dbSNP
rs1422157059 664 dbSNP
rs988307310 665 dbSNP
rs1475578311 673 dbSNP
rs72996949 679 dbSNP
rs969570728 682 dbSNP
rs982636943 688 dbSNP
rs371760349 702 dbSNP
rs540354504 704 dbSNP
rs946800246 706 dbSNP
rs1413303663 707 dbSNP
rs1220489608 714 dbSNP
rs1458406992 715 dbSNP
rs1319673682 716 dbSNP
rs766964684 726 dbSNP
rs939837371 727 dbSNP
rs1043790324 733 dbSNP
rs1276319978 735 dbSNP
rs1406847576 739 dbSNP
rs188547782 740 dbSNP
rs937996213 755 dbSNP
rs374831724 759 dbSNP
rs1456876381 760 dbSNP
rs1356636184 780 dbSNP
rs1171636621 789 dbSNP
rs113751065 792 dbSNP
rs1422482108 794 dbSNP
rs1049648245 796 dbSNP
rs1167864767 796 dbSNP
rs1269031901 805 dbSNP
rs1294859845 810 dbSNP
rs889488908 817 dbSNP
rs1348459873 822 dbSNP
rs1234380632 823 dbSNP
rs115643804 826 dbSNP
rs939901394 827 dbSNP
rs1288951182 843 dbSNP
rs1225636282 851 dbSNP
rs139055519 856 dbSNP
rs1037280429 859 dbSNP
rs755817807 860 dbSNP
rs1300756963 861 dbSNP
rs1385585739 863 dbSNP
rs530704201 867 dbSNP
rs191469134 869 dbSNP
rs1299038691 875 dbSNP
rs141518526 877 dbSNP
rs534733093 878 dbSNP
rs1028052299 886 dbSNP
rs546350492 894 dbSNP
rs889482647 904 dbSNP
rs1007887969 913 dbSNP
rs147070398 923 dbSNP
rs549725264 928 dbSNP
rs937223726 929 dbSNP
rs1410074255 932 dbSNP
rs1181887281 935 dbSNP
rs1019245471 936 dbSNP
rs542728996 937 dbSNP
rs115490519 941 dbSNP
rs1015033513 943 dbSNP
rs1461980616 946 dbSNP
rs962091669 949 dbSNP
rs973471961 952 dbSNP
rs1308369181 953 dbSNP
rs1240120299 954 dbSNP
rs1021555031 968 dbSNP
rs968221362 970 dbSNP
rs1387629760 973 dbSNP
rs1166552127 984 dbSNP
rs556987539 985 dbSNP
rs1402485776 987 dbSNP
rs931158943 989 dbSNP
rs138206937 990 dbSNP
rs1439082214 997 dbSNP
rs553810656 1000 dbSNP
rs1424551792 1008 dbSNP
rs540114362 1013 dbSNP
rs1198755326 1025 dbSNP
rs943705531 1034 dbSNP
rs1308433151 1044 dbSNP
rs1372132378 1049 dbSNP
rs1216510345 1050 dbSNP
rs1352221392 1057 dbSNP
rs1317539113 1058 dbSNP
rs558364453 1064 dbSNP
rs11682492 1067 dbSNP
rs992121730 1068 dbSNP
rs1393969799 1072 dbSNP
rs71049510 1088 dbSNP
rs917882100 1089 dbSNP
rs939953032 1095 dbSNP
rs146366566 1097 dbSNP
rs561991534 1098 dbSNP
rs573704444 1099 dbSNP
rs906760450 1107 dbSNP
rs1003557003 1113 dbSNP
rs1049974515 1117 dbSNP
rs1185650616 1118 dbSNP
rs1430584459 1119 dbSNP
rs1204658181 1130 dbSNP
rs889535654 1143 dbSNP
rs1449893240 1150 dbSNP
rs1193056722 1152 dbSNP
rs1439864871 1153 dbSNP
rs1310744087 1155 dbSNP
rs1354392098 1157 dbSNP
rs1294624193 1159 dbSNP
rs1218776484 1161 dbSNP
rs1237405421 1162 dbSNP
rs1279561538 1164 dbSNP
rs749143242 1164 dbSNP
rs1242144300 1165 dbSNP
rs1336805795 1165 dbSNP
rs370202999 1168 dbSNP
rs71049511 1168 dbSNP
rs71293150 1168 dbSNP
rs376160377 1170 dbSNP
rs1304858626 1176 dbSNP
rs1387318738 1177 dbSNP
rs1389740963 1178 dbSNP
rs1184877082 1179 dbSNP
rs1161299819 1181 dbSNP
rs1463664742 1184 dbSNP
rs377071984 1184 dbSNP
rs1448533110 1185 dbSNP
rs544237579 1186 dbSNP
rs1318780817 1187 dbSNP
rs74800663 1187 dbSNP
rs77203928 1189 dbSNP
rs1412543357 1191 dbSNP
rs1333474400 1192 dbSNP
rs373151004 1193 dbSNP
rs376408107 1194 dbSNP
rs1338820637 1196 dbSNP
rs1363043486 1198 dbSNP
rs370930687 1200 dbSNP
rs1227965793 1201 dbSNP
rs374581702 1203 dbSNP
rs368216751 1204 dbSNP
rs370855221 1210 dbSNP
rs1200196237 1212 dbSNP
rs1298585923 1212 dbSNP
rs1167281539 1213 dbSNP
rs1341986427 1216 dbSNP
rs373972400 1219 dbSNP
rs202125763 1227 dbSNP
rs1217799058 1229 dbSNP
rs562523839 1233 dbSNP
rs75269142 1234 dbSNP
rs371347962 1237 dbSNP
rs375750945 1238 dbSNP
rs1315498509 1239 dbSNP
rs1027732207 1240 dbSNP
rs545661855 1242 dbSNP
rs564330515 1244 dbSNP
rs952662093 1255 dbSNP
rs1245670106 1261 dbSNP
rs375188677 1263 dbSNP
rs528228092 1265 dbSNP
rs1171515681 1266 dbSNP
rs1401239087 1273 dbSNP
rs781068754 1273 dbSNP
rs2975787 1274 dbSNP
rs1476948191 1276 dbSNP
rs1171807329 1278 dbSNP
rs116619940 1280 dbSNP
rs551415371 1287 dbSNP
rs550621992 1288 dbSNP
rs979617831 1294 dbSNP
rs1053472931 1296 dbSNP
rs1034219218 1298 dbSNP
rs914954851 1303 dbSNP
rs1184370012 1309 dbSNP
rs776208654 1309 dbSNP
rs948237203 1309 dbSNP
rs1197618292 1310 dbSNP
rs959455938 1311 dbSNP
rs906679956 1315 dbSNP
rs992174118 1316 dbSNP
rs568853870 1317 dbSNP
rs917934193 1321 dbSNP
rs879625226 1328 dbSNP
rs973088591 1333 dbSNP
rs1334872819 1336 dbSNP
rs540152365 1338 dbSNP
rs1028157350 1340 dbSNP
rs1160768535 1351 dbSNP
rs1018705792 1352 dbSNP
rs1380059771 1355 dbSNP
rs931175769 1359 dbSNP
rs1434517123 1362 dbSNP
rs1049582442 1363 dbSNP
rs1437356880 1365 dbSNP
rs749575098 1371 dbSNP
rs1274663605 1373 dbSNP
rs73116228 1376 dbSNP
rs1218689408 1381 dbSNP
rs1275941251 1381 dbSNP
rs1354344574 1386 dbSNP
rs965167650 1400 dbSNP
rs567054342 1406 dbSNP
rs976678707 1408 dbSNP
rs1040794497 1409 dbSNP
rs891490983 1410 dbSNP
rs534090365 1419 dbSNP
rs1420778465 1420 dbSNP
rs555917303 1420 dbSNP
rs904103223 1429 dbSNP
rs144548697 1432 dbSNP
rs1197641091 1436 dbSNP
rs771186107 1439 dbSNP
rs774791059 1448 dbSNP
rs1180004294 1452 dbSNP
rs1472299298 1452 dbSNP
rs1195221462 1458 dbSNP
rs1235183623 1458 dbSNP
rs148022991 1459 dbSNP
rs1013647896 1460 dbSNP
rs142677828 1462 dbSNP
rs898041628 1466 dbSNP
rs577589078 1468 dbSNP
rs1387178547 1471 dbSNP
rs546085503 1471 dbSNP
rs961707587 1479 dbSNP
rs33986981 1486 dbSNP
rs919879615 1490 dbSNP
rs537714950 1491 dbSNP
rs1346602009 1492 dbSNP
rs1400720547 1494 dbSNP
rs558905398 1495 dbSNP
rs1296861730 1496 dbSNP
rs911079307 1517 dbSNP
rs1287058893 1519 dbSNP
rs1007668869 1520 dbSNP
rs943836694 1544 dbSNP
rs1350828365 1545 dbSNP
rs1040845382 1546 dbSNP
rs1278772828 1550 dbSNP
rs912978719 1552 dbSNP
rs1353578369 1555 dbSNP
rs146021437 1557 dbSNP
rs1477851287 1558 dbSNP
rs1042733582 1559 dbSNP
rs2975788 1560 dbSNP
rs1191417788 1564 dbSNP
rs555929213 1574 dbSNP
rs1489458808 1576 dbSNP
rs1247006919 1578 dbSNP
rs1220557912 1587 dbSNP
rs1450041451 1590 dbSNP
rs1001141441 1591 dbSNP
rs529031321 1592 dbSNP
rs1250734861 1593 dbSNP
rs1317339217 1595 dbSNP
rs1276457060 1608 dbSNP
rs1229906132 1609 dbSNP
rs555531023 1613 dbSNP
rs761386836 1616 dbSNP
rs764881489 1619 dbSNP
rs1013697120 1620 dbSNP
rs1434791507 1623 dbSNP
rs772994914 1624 dbSNP
rs1025051437 1638 dbSNP
rs1332921795 1639 dbSNP
rs1365616519 1639 dbSNP
rs961485168 1641 dbSNP
rs1471843731 1652 dbSNP
rs77983700 1653 dbSNP
rs1027001881 1659 dbSNP
rs545134540 1662 dbSNP
rs1425821189 1668 dbSNP
rs1429386272 1670 dbSNP
rs1426734329 1672 dbSNP
rs914935181 1672 dbSNP
rs1239818421 1677 dbSNP
rs1199502406 1700 dbSNP
rs952800050 1703 dbSNP
rs969457936 1714 dbSNP
rs568892990 1717 dbSNP
rs766033169 1718 dbSNP
rs1313250406 1720 dbSNP
rs911129098 1722 dbSNP
rs532905748 1730 dbSNP
rs1218026120 1737 dbSNP
rs183612690 1738 dbSNP
rs939503338 1739 dbSNP
rs373112156 1764 dbSNP
rs1399096720 1770 dbSNP
rs913031209 1770 dbSNP
rs1295902060 1779 dbSNP
rs1467152128 1786 dbSNP
rs1359282408 1794 dbSNP
rs1309775704 1795 dbSNP
rs567089960 1802 dbSNP
rs978893443 1807 dbSNP
rs1179037250 1810 dbSNP
rs925665488 1812 dbSNP
rs1248711725 1820 dbSNP
rs1183869301 1822 dbSNP
rs1483602333 1826 dbSNP
rs936989363 1831 dbSNP
rs1255557085 1834 dbSNP
rs1208628268 1835 dbSNP
rs1356488998 1835 dbSNP
rs919524342 1838 dbSNP
rs1239912633 1843 dbSNP
rs751377789 1847 dbSNP
rs1304381549 1854 dbSNP
rs2975789 1855 dbSNP
rs1379256302 1858 dbSNP
rs895397866 1858 dbSNP
rs889164435 1859 dbSNP
rs949598129 1861 dbSNP
rs1046554743 1863 dbSNP
rs901910437 1868 dbSNP
rs1273655537 1887 dbSNP
rs767464872 1892 dbSNP
rs1361890686 1894 dbSNP
rs1167172779 1903 dbSNP
rs752668341 1905 dbSNP
rs1255493192 1917 dbSNP
rs897288135 1918 dbSNP
rs756178343 1929 dbSNP
rs1027469308 1930 dbSNP
rs1253992514 1931 dbSNP
rs777884991 1946 dbSNP
rs867844133 1954 dbSNP
rs1010863008 1956 dbSNP
rs1321962680 1966 dbSNP
rs1186960762 1977 dbSNP
rs555719159 1979 dbSNP
rs1446678367 1984 dbSNP
rs535303932 1988 dbSNP
rs1166889059 1992 dbSNP
rs71428448 1994 dbSNP
rs1018244610 1995 dbSNP
rs567487254 1997 dbSNP
rs980806891 2002 dbSNP
rs1298700529 2004 dbSNP
rs1462813952 2010 dbSNP
rs537971569 2013 dbSNP
rs976632083 2022 dbSNP
rs1300466391 2023 dbSNP
rs139827603 2041 dbSNP
rs13395858 2042 dbSNP
rs545115045 2046 dbSNP
rs971795522 2053 dbSNP
rs1384275595 2056 dbSNP
rs1424469604 2062 dbSNP
rs1193567018 2064 dbSNP
rs919450971 2066 dbSNP
rs930806970 2072 dbSNP
rs985097291 2078 dbSNP
rs553410156 2082 dbSNP
rs554135578 2083 dbSNP
rs1217879870 2093 dbSNP
rs1324626787 2097 dbSNP
rs746268867 2108 dbSNP
rs1253976471 2110 dbSNP
rs991116054 2111 dbSNP
rs1200899502 2114 dbSNP
rs1389803800 2120 dbSNP
rs1040323247 2122 dbSNP
rs150756160 2126 dbSNP
rs1244371165 2137 dbSNP
rs1401103772 2138 dbSNP
rs1170074064 2140 dbSNP
rs949648751 2159 dbSNP
rs1474674482 2160 dbSNP
rs1379912593 2166 dbSNP
rs1046610844 2168 dbSNP
rs1432935674 2176 dbSNP
rs1053128848 2177 dbSNP
rs897346520 2178 dbSNP
rs1458825697 2179 dbSNP
rs930125012 2183 dbSNP
rs1048506822 2184 dbSNP
rs1258069712 2188 dbSNP
rs1194768550 2190 dbSNP
rs1337316565 2197 dbSNP
rs540503940 2204 dbSNP
rs1276517066 2208 dbSNP
rs561877755 2210 dbSNP
rs1369969396 2217 dbSNP
rs776110822 2218 dbSNP
rs1186986734 2221 dbSNP
rs1022215066 2238 dbSNP
rs1330714994 2252 dbSNP
rs1408299341 2253 dbSNP
rs190573713 2254 dbSNP
rs901150093 2255 dbSNP
rs998125277 2257 dbSNP
rs1173015030 2259 dbSNP
rs1393598402 2259 dbSNP
rs1180907347 2260 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions TZM-bl
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM1462574. RNA binding protein: AGO2. Condition:TZM-bl ami BaL ...

- Whisnant AW; Bogerd HP; Flores O; Ho P; et al., 2013, mBio.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1
miRNA  3' ugcaaauuuaaaguGGGGAAGa 5'
                        ||||||| 
Target 5' -----------cuuCCCCUUCa 3'
1 - 11
Article - Whisnant AW; Bogerd HP; Flores O; Ho P; et al.
- mBio, 2013
UNLABELLED: The question of how HIV-1 interfaces with cellular microRNA (miRNA) biogenesis and effector mechanisms has been highly controversial. Here, we first used deep sequencing of small RNAs present in two different infected cell lines (TZM-bl and C8166) and two types of primary human cells (CD4(+) peripheral blood mononuclear cells [PBMCs] and macrophages) to unequivocally demonstrate that HIV-1 does not encode any viral miRNAs. Perhaps surprisingly, we also observed that infection of T cells by HIV-1 has only a modest effect on the expression of cellular miRNAs at early times after infection. Comprehensive analysis of miRNA binding to the HIV-1 genome using the photoactivatable ribonucleoside-induced cross-linking and immunoprecipitation (PAR-CLIP) technique revealed several binding sites for cellular miRNAs, a subset of which were shown to be capable of mediating miRNA-mediated repression of gene expression. However, the main finding from this analysis is that HIV-1 transcripts are largely refractory to miRNA binding, most probably due to extensive viral RNA secondary structure. Together, these data demonstrate that HIV-1 neither encodes viral miRNAs nor strongly influences cellular miRNA expression, at least early after infection, and imply that HIV-1 transcripts have evolved to avoid inhibition by preexisting cellular miRNAs by adopting extensive RNA secondary structures that occlude most potential miRNA binding sites. IMPORTANCE: MicroRNAs (miRNAs) are a ubiquitous class of small regulatory RNAs that serve as posttranscriptional regulators of gene expression. Previous work has suggested that HIV-1 might subvert the function of the cellular miRNA machinery by expressing viral miRNAs or by dramatically altering the level of cellular miRNA expression. Using very sensitive approaches, we now demonstrate that neither of these ideas is in fact correct. Moreover, HIV-1 transcripts appear to largely avoid regulation by cellular miRNAs by adopting an extensive RNA secondary structure that occludes the ability of cellular miRNAs to interact with viral mRNAs. Together, these data suggest that HIV-1, rather than seeking to control miRNA function in infected cells, has instead evolved a mechanism to become largely invisible to cellular miRNA effector mechanisms.
LinkOut: [PMID: 23592263]
CLIP-seq Support 1 for dataset GSM1462574
Method / RBP PAR-CLIP / AGO2
Cell line / Condition TZM-bl / TZM-bl ami BaL
Location of target site ENST00000319838.5 | 3UTR | CUUCCCCUUCACCUUCUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23592263 / GSE59944
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
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133 hsa-miR-3179 Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT102087 GIGYF1 GRB10 interacting GYF protein 1 2 4
MIRT110061 OGT O-linked N-acetylglucosamine (GlcNAc) transferase 2 6
MIRT112198 BTG2 BTG anti-proliferation factor 2 2 2
MIRT117668 SCAMP4 secretory carrier membrane protein 4 2 2
MIRT146657 MINK1 misshapen like kinase 1 2 2
MIRT175505 ZBTB33 zinc finger and BTB domain containing 33 2 4
MIRT180535 TXNIP thioredoxin interacting protein 2 2
MIRT190624 BCL2L2-PABPN1 BCL2L2-PABPN1 readthrough 2 2
MIRT190650 PABPN1 poly(A) binding protein nuclear 1 2 2
MIRT366902 NONO non-POU domain containing octamer binding 2 2
MIRT443554 ZFP3 ZFP3 zinc finger protein 2 2
MIRT445953 MLLT11 MLLT11, transcription factor 7 cofactor 2 2
MIRT446042 HMCN1 hemicentin 1 2 2
MIRT447968 MSH6 mutS homolog 6 2 2
MIRT448634 ONECUT1 one cut homeobox 1 2 2
MIRT449316 MRO maestro 2 2
MIRT451380 C19orf43 telomerase RNA component interacting RNase 2 2
MIRT451547 CIAPIN1 cytokine induced apoptosis inhibitor 1 2 2
MIRT451807 CDCA3 cell division cycle associated 3 2 4
MIRT451916 ILK integrin linked kinase 2 2
MIRT451938 TMPRSS5 transmembrane protease, serine 5 2 2
MIRT452189 KIAA1456 KIAA1456 2 2
MIRT452498 HMGXB3 HMG-box containing 3 2 2
MIRT452548 ZNF467 zinc finger protein 467 2 2
MIRT453844 SDK1 sidekick cell adhesion molecule 1 2 2
MIRT454515 ZFYVE27 zinc finger FYVE-type containing 27 2 2
MIRT455363 KDM5C lysine demethylase 5C 2 2
MIRT455455 EPB41L4B erythrocyte membrane protein band 4.1 like 4B 2 2
MIRT455628 PABPC1L2B poly(A) binding protein cytoplasmic 1 like 2B 2 10
MIRT455639 PABPC1L2A poly(A) binding protein cytoplasmic 1 like 2A 2 10
MIRT455690 GLO1 glyoxalase I 2 2
MIRT456300 ASH1L ASH1 like histone lysine methyltransferase 2 2
MIRT456784 MTHFSD methenyltetrahydrofolate synthetase domain containing 2 2
MIRT456819 PIGP phosphatidylinositol glycan anchor biosynthesis class P 2 2
MIRT457566 ZNF34 zinc finger protein 34 2 2
MIRT457604 IDS iduronate 2-sulfatase 2 2
MIRT458236 NXPH3 neurexophilin 3 2 2
MIRT458313 TNFAIP8L3 TNF alpha induced protein 8 like 3 2 2
MIRT458350 NOC2L NOC2 like nucleolar associated transcriptional repressor 2 2
MIRT458670 GPR35 G protein-coupled receptor 35 2 2
MIRT459675 VPS37C VPS37C, ESCRT-I subunit 2 2
MIRT461126 RAB36 RAB36, member RAS oncogene family 2 2
MIRT461918 NECAB3 N-terminal EF-hand calcium binding protein 3 2 2
MIRT462301 PPM1H protein phosphatase, Mg2+/Mn2+ dependent 1H 2 2
MIRT463520 ZBTB7B zinc finger and BTB domain containing 7B 2 2
MIRT464378 URM1 ubiquitin related modifier 1 2 2
MIRT464614 UBE4B ubiquitination factor E4B 2 2
MIRT464711 UBE2V1 ubiquitin conjugating enzyme E2 V1 2 2
MIRT465520 PRICKLE4 prickle planar cell polarity protein 4 2 2
MIRT465974 TMEM189-UBE2V1 TMEM189-UBE2V1 readthrough 2 2
MIRT466058 TMEM189 transmembrane protein 189 2 2
MIRT466548 TBL1XR1 transducin beta like 1 X-linked receptor 1 2 2
MIRT466647 TAGLN2 transgelin 2 2 2
MIRT467357 SP2 Sp2 transcription factor 2 2
MIRT468744 SDC2 syndecan 2 2 2
MIRT470244 PRRC2A proline rich coiled-coil 2A 2 2
MIRT471426 PDIA6 protein disulfide isomerase family A member 6 2 2
MIRT471732 OTUB1 OTU deubiquitinase, ubiquitin aldehyde binding 1 2 2
MIRT472190 NHP2L1 small nuclear ribonucleoprotein 13 2 2
MIRT472450 NAV2 neuron navigator 2 2 6
MIRT474563 KLHDC3 kelch domain containing 3 2 2
MIRT474936 KCTD15 potassium channel tetramerization domain containing 15 2 2
MIRT475165 IP6K1 inositol hexakisphosphate kinase 1 2 2
MIRT475399 ICMT isoprenylcysteine carboxyl methyltransferase 2 4
MIRT475426 ICK intestinal cell kinase 2 2
MIRT477090 FAM168A family with sequence similarity 168 member A 2 2
MIRT478458 DAB2 DAB2, clathrin adaptor protein 2 2
MIRT478953 COX15 COX15, cytochrome c oxidase assembly homolog 2 2
MIRT480096 CALR calreticulin 2 2
MIRT481924 ANKRD33B ankyrin repeat domain 33B 2 2
MIRT483217 APOA1 apolipoprotein A1 2 6
MIRT483882 TGIF1 TGFB induced factor homeobox 1 2 2
MIRT483923 SPSB1 splA/ryanodine receptor domain and SOCS box containing 1 2 2
MIRT483942 LENG8 leukocyte receptor cluster member 8 2 4
MIRT484209 SUMO1 small ubiquitin-like modifier 1 2 2
MIRT484512 SYT7 synaptotagmin 7 2 2
MIRT484709 RNF11 ring finger protein 11 2 2
MIRT485356 MYO1C myosin IC 2 4
MIRT485615 FOSL1 FOS like 1, AP-1 transcription factor subunit 2 4
MIRT486584 ZNF619 zinc finger protein 619 2 2
MIRT487013 C2orf82 chromosome 2 open reading frame 82 2 2
MIRT487621 C20orf96 chromosome 20 open reading frame 96 2 2
MIRT487801 GPR20 G protein-coupled receptor 20 2 4
MIRT488134 GPR107 G protein-coupled receptor 107 2 2
MIRT488773 FXYD1 FXYD domain containing ion transport regulator 1 2 2
MIRT488854 UBTF upstream binding transcription factor, RNA polymerase I 2 2
MIRT489783 GRINA glutamate ionotropic receptor NMDA type subunit associated protein 1 2 2
MIRT490102 FN3K fructosamine 3 kinase 2 2
MIRT490389 LHFPL3 LHFPL tetraspan subfamily member 3 2 2
MIRT490434 MYL9 myosin light chain 9 2 2
MIRT490451 GLUD1 glutamate dehydrogenase 1 2 2
MIRT490880 OSBP oxysterol binding protein 2 2
MIRT491037 ALPK3 alpha kinase 3 2 2
MIRT491250 HCN2 hyperpolarization activated cyclic nucleotide gated potassium and sodium channel 2 2 2
MIRT491748 SEMA3F semaphorin 3F 2 2
MIRT492235 SLC48A1 solute carrier family 48 member 1 2 2
MIRT492490 RAPGEF1 Rap guanine nucleotide exchange factor 1 2 2
MIRT492505 RANBP10 RAN binding protein 10 2 4
MIRT492773 PDGFB platelet derived growth factor subunit B 2 2
MIRT492922 NFAT5 nuclear factor of activated T-cells 5 2 2
MIRT493459 ITFG3 family with sequence similarity 234 member A 2 2
MIRT493654 HDLBP high density lipoprotein binding protein 2 2
MIRT494011 DUSP9 dual specificity phosphatase 9 2 2
MIRT499412 PLCG2 phospholipase C gamma 2 2 4
MIRT499552 C15orf43 telomere repeat binding bouquet formation protein 2 2 2
MIRT501836 NCOA2 nuclear receptor coactivator 2 2 2
MIRT501950 MAT2A methionine adenosyltransferase 2A 2 10
MIRT504066 KCTD12 potassium channel tetramerization domain containing 12 2 4
MIRT504509 PPP1R9B protein phosphatase 1 regulatory subunit 9B 2 2
MIRT508466 HOXB6 homeobox B6 2 4
MIRT512373 CPM carboxypeptidase M 2 2
MIRT513578 EVX1 even-skipped homeobox 1 2 2
MIRT517763 ZNF366 zinc finger protein 366 2 4
MIRT519773 ZNF354B zinc finger protein 354B 2 8
MIRT523568 GGCX gamma-glutamyl carboxylase 2 4
MIRT532802 CLDN11 claudin 11 2 2
MIRT544299 TSPYL1 TSPY like 1 2 2
MIRT544862 MYH2 myosin heavy chain 2 2 4
MIRT556731 KLHL15 kelch like family member 15 2 4
MIRT564347 AKR1B10 aldo-keto reductase family 1 member B10 2 2
MIRT568924 SMCR8 Smith-Magenis syndrome chromosome region, candidate 8 2 2
MIRT569012 CXorf36 chromosome X open reading frame 36 2 2
MIRT569256 FAM129B family with sequence similarity 129 member B 2 2
MIRT569591 PRELP proline and arginine rich end leucine rich repeat protein 2 2
MIRT569779 SAMD14 sterile alpha motif domain containing 14 2 2
MIRT570034 FAM228A family with sequence similarity 228 member A 2 2
MIRT573803 FRMPD4 FERM and PDZ domain containing 4 2 2
MIRT574190 ZNF264 zinc finger protein 264 2 2
MIRT576153 Hmox1 heme oxygenase 1 2 2
MIRT611311 CA8 carbonic anhydrase 8 2 4
MIRT673429 APAF1 apoptotic peptidase activating factor 1 2 2
MIRT674976 SH3BP2 SH3 domain binding protein 2 2 2
MIRT692712 MEAF6 MYST/Esa1 associated factor 6 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-3179 Gemcitabine 60750 NSC613327 approved resistant High Pancreatic Cancer cell line (AsPC-1)
hsa-miR-3179 Gefitinib 123631 NSC715055 approved sensitive cell line (HCC827)
hsa-miR-3179 Gefitinib 123631 NSC715055 approved sensitive cell line (PC9)
hsa-miR-3179 Osimertinib 71496458 NSC779217 approved sensitive cell line (HCC827)
hsa-miR-3179 Osimertinib 71496458 NSC779217 approved sensitive cell line (PC9)
hsa-miR-3179 Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-3179 Gemcitabine 60750 NSC613327 approved sensitive cell line (PANC-1) (100 ng/ml)
hsa-miR-3179 Gemcitabine 60750 NSC613327 approved sensitive cell line (PANC-1) (1500 ng/ml)

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