miRTarBase - #MIRT458683


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pre-miRNA Information
pre-miRNA hsa-mir-378g   
Genomic Coordinates chr1: 94745860 - 94745900
Description Homo sapiens miR-378g stem-loop
Comment None
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-378g
Sequence 2| ACUGGGCUUGGAGUCAGAAG |21
Evidence Experimental
Experiments Illumina
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol MRI1   
Synonyms M1Pi, MRDI, MTNA, Ypr118w
Description methylthioribose-1-phosphate isomerase 1
Transcript NM_001031727   
Other Transcripts NM_032285   
Expression
Putative miRNA Targets on MRI1
3'UTR of MRI1
(miRNA target sites are highlighted)		 
>MRI1|NM_001031727|3'UTR
   1 CCAACTCAGCTCTCCCTAGCCTGCCTCTCTAGGTTTTTCAATACATTTCTTGAATGGCTACCCAAAAGCTGACCGTCCAG
  81 CCCCTGACCACACTTGTTCCTAGTGCAGGGAGCTCAGACAGGGCCTTCCATCTAGAGCCCAGCACCTAGAGCCAGGCTGC
 161 CCAGATTCAAATCCTGACTCCGCCACTTTTCCCACTGTATGATCTTGGGCAAGTCACTTCACCTCTCTGTGCCTTGGTTT
 241 CCTCATTTATAAAATGTGGATAACAGGCCGGGCGCAGTGGCTCACACCTGTAATCCCAGCACTTTGGGAGGCCGAGGCAG
 321 GTGGATCACAAGATCAGGAGATTGAGACCATCCTGGCTAACATGGTGAAACCCCATCTCTACTAAAAATACAAAAAATTA
 401 GCCGGGTGTGGTGGTGGGCACCTGCAGTCCCAGCTACTTGGGAGGCTGAGGCAGGAGAATGGCGTGAAACTGGGAGGCAG
 481 AGCTTGCAGTGAGCCGAGATAGCGCCACTGCACTCCAGCCTGGGCAACAGAGCGAGACTCCGTCTCAAAAATAAATATAA
 561 TTAATTAATTATTTAATTAAAAAAATAAAAAATAAATGTGGATAATACTAGTACCTCCCTCTTAAGGTCAGGGCTGGAGC
 641 TAGGGTGACATCTCCAGGGCAGAATTTTAAGAGGACACCAAAAAAGCTCAGCAACCAAGATAAAAAATATTTTAAAGCAA
 721 TATTTTGTTTTGGGTTTTTTTTTTTTGAGATCAAGTATCACTCGTTACCCAGGCTGGAATGTAGAGGCGAGATCTCAGCT
 801 CACTGAAACCTGTGCCTCCCCGGTTCAAGCGATTCTCCTGCCACAGCCTCCTGAGTAGCTGGGATTACAGGCATGCGCCA
 881 CCATGCCCAGCTAATTTTTCTATTTTTAGTAGAGACATGATTTCACCATGTTGGCCAGGCTGGTCTCGAACTCCTGACTC
 961 AAATGATCCCCCTGCCTCAGCCTCCCAAAGTGCTGGGACTACAGGCATGAGCCACTGTGCCTGACCTTACAGCAGTATTT
1041 TTTAAAAATCAAAATTAATGCAAAAATCCATGATGAGGCCAGGCTTGGTGGCTCATGCCTGTAATTCCAGCACTTTGGGA
1121 GGATCCCTTGAGCCCAGGTGTTTGAGACCAGTTTGGGTAACATAGGAAGAGCTTGTCTCTACAAACAAAAATTTAAAAAC
1201 AATGAGCTGGGCATGGAACTCACACCTCTAGCCCCAGCTACTCAGGCTGAAGTGGGAGGATGGCTTGAGCCCAGGAGTTC
1281 AAGGATGCAGTGTGCTTTGATTGCACTACTGCACTTCACCCTAAGCAACAGAGTGAGACCCCATCTCTTTAAAAAAAAAA
1361 AAAAATCCATGATGAACAAAACAAGTATTTGTTTGAGACGGGGTCTCGCTCTGTCGCCCAGGCTGGAGTACAGTGGTGCC
1441 ATCTCAGCTCACTGCAACCTCCGCCTTCTGGGTTCAAGCGACTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGATTACAGG
1521 AGCCTGGCACTATGCCTGGCTAATTTTTGTATTTTTATTGGAGACACCATGTTAGTCGTGGCTGGTCTCCAACTCCTGAC
1601 CTCGGGTGATCCGCGCCCCGCGGCCTCCGAAAGTGCTGGGATTACAAGCGTGAGCCACCGTGCCCGGCCTAAATAAAATT
1681 TTGAAGAGGCTAGAACCCCGCACTTGTGCCTTGAGCTTACTGACCTCAACACCCTGGTTCCACTAAAACTTTATTTACAA
1761 AATTATGCTGCCGGTCTGCAGGATGTAGTTTAACAATTTGATTATTTTGGATATTAAAATATTTTTTAAGTCTTGAAAAT
1841 ATTGTTTACTATTACCAAAGTTTTTGAACCTTCTTAAATTCTGTACCAGAGGTGAGTGCCACACCCTAACCTAGTCTGAG
1921 TTTTTATGTGTAAAGATCATAAAACGTTGTAAGTTTTCTAAAACACATAAGCTCTCAATAAACGTTAGCTTATCATTGTC
2001 AAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' gaagACUGAGGUUCGGGUCa 5'
              ||:|| ::||||||| 
Target 5' aggaTGGCT-TGAGCCCAGg 3'
 1257 - 1275 155.00 -16.90
2 
miRNA  3' gaaGACUG-AGGU-UCGGGUCa 5'
             ||  | ||:| ||||||| 
Target 5' ggcCTTCCATCTAGAGCCCAGc 3'
 122 - 143 149.00 -17.10
3 
miRNA  3' gaagaCUGAGG--UUCGGGUCa 5'
               ||: ||  :||||||| 
Target 5' gggagGATCCCTTGAGCCCAGg 3'
 1117 - 1138 149.00 -15.40
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN17154038 5 COSMIC
COSN31552799 37 COSMIC
COSN1211183 72 COSMIC
COSN30502573 75 COSMIC
COSN31542904 109 COSMIC
COSN28602420 285 COSMIC
COSN28598451 287 COSMIC
COSN28599682 294 COSMIC
COSN28881067 314 COSMIC
COSN28595770 337 COSMIC
COSN29233717 465 COSMIC
COSN24107430 572 COSMIC
COSN24157207 580 COSMIC
COSN23123750 608 COSMIC
COSN28570709 1252 COSMIC
COSN28568576 1314 COSMIC
COSN28570686 1324 COSMIC
COSN28569649 1325 COSMIC
COSN30673180 1364 COSMIC
COSN31782111 1366 COSMIC
COSN7354464 1604 COSMIC
COSN21077092 1714 COSMIC
COSN21483741 1836 COSMIC
COSN32058094 1930 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs901036730 1 dbSNP
rs1443472307 2 dbSNP
rs1469071 5 dbSNP
rs758775428 8 dbSNP
rs778302139 10 dbSNP
rs747443089 12 dbSNP
rs771515625 13 dbSNP
rs746052543 14 dbSNP
rs748893321 16 dbSNP
rs1469528652 19 dbSNP
rs1211481416 20 dbSNP
rs768354051 21 dbSNP
rs774155872 24 dbSNP
rs569521698 25 dbSNP
rs1244335083 26 dbSNP
rs772027126 27 dbSNP
rs200883876 29 dbSNP
rs1170038184 34 dbSNP
rs1418720955 41 dbSNP
rs1463192326 42 dbSNP
rs773104020 44 dbSNP
rs142846234 45 dbSNP
rs1438407988 56 dbSNP
rs952784632 60 dbSNP
rs1240372933 61 dbSNP
rs1199631911 74 dbSNP
rs1004199440 75 dbSNP
rs558298182 76 dbSNP
rs1219014017 79 dbSNP
rs576868553 81 dbSNP
rs1322930454 92 dbSNP
rs1315155974 107 dbSNP
rs1314621421 115 dbSNP
rs1374608187 123 dbSNP
rs1311419444 126 dbSNP
rs1034799645 130 dbSNP
rs770091366 136 dbSNP
rs1389835365 143 dbSNP
rs1291940475 147 dbSNP
rs1376035169 148 dbSNP
rs1459657626 149 dbSNP
rs1398844306 152 dbSNP
rs992938729 153 dbSNP
rs917411220 156 dbSNP
rs1035238806 161 dbSNP
rs967550771 179 dbSNP
rs977644502 182 dbSNP
rs991125124 183 dbSNP
rs1382680127 186 dbSNP
rs1179879629 192 dbSNP
rs1227650238 198 dbSNP
rs541169659 198 dbSNP
rs963140686 201 dbSNP
rs1273903899 221 dbSNP
rs1344727674 223 dbSNP
rs1217878380 228 dbSNP
rs1350924616 231 dbSNP
rs1283086841 245 dbSNP
rs554369099 246 dbSNP
rs973146852 249 dbSNP
rs1330242618 252 dbSNP
rs936298860 255 dbSNP
rs572684560 260 dbSNP
rs919091275 262 dbSNP
rs1388702817 270 dbSNP
rs1053448238 271 dbSNP
rs879488097 274 dbSNP
rs377569249 275 dbSNP
rs1159584299 277 dbSNP
rs1465990035 282 dbSNP
rs1376233591 287 dbSNP
rs987706339 289 dbSNP
rs1434154794 293 dbSNP
rs911844605 294 dbSNP
rs1216542934 298 dbSNP
rs942434909 301 dbSNP
rs1040785645 304 dbSNP
rs1261032413 305 dbSNP
rs1329157038 309 dbSNP
rs1448843145 311 dbSNP
rs900989606 312 dbSNP
rs1039031012 314 dbSNP
rs1235117179 315 dbSNP
rs993965989 318 dbSNP
rs1324079917 322 dbSNP
rs1277798921 323 dbSNP
rs1398387255 325 dbSNP
rs1342386386 337 dbSNP
rs572840831 341 dbSNP
rs1395913158 346 dbSNP
rs1476899980 348 dbSNP
rs1400648227 352 dbSNP
rs1174875469 362 dbSNP
rs1175352138 363 dbSNP
rs888363752 368 dbSNP
rs3180008 382 dbSNP
rs368749940 391 dbSNP
rs1169448647 393 dbSNP
rs1476650631 395 dbSNP
rs1425106212 402 dbSNP
rs1005922554 404 dbSNP
rs1034339181 405 dbSNP
rs377578606 408 dbSNP
rs556584100 408 dbSNP
rs958726525 408 dbSNP
rs1461549439 409 dbSNP
rs749595377 419 dbSNP
rs1024412014 421 dbSNP
rs151047310 426 dbSNP
rs1329064929 431 dbSNP
rs1271029037 432 dbSNP
rs1035585247 434 dbSNP
rs895423792 451 dbSNP
rs1012480726 452 dbSNP
rs1142084 454 dbSNP
rs1454000808 458 dbSNP
rs561499546 464 dbSNP
rs1306014844 465 dbSNP
rs1022649488 471 dbSNP
rs926147179 473 dbSNP
rs1398159663 480 dbSNP
rs1168198897 481 dbSNP
rs1472176817 484 dbSNP
rs957640376 485 dbSNP
rs1240002756 494 dbSNP
rs186790830 495 dbSNP
rs1185281600 496 dbSNP
rs910874177 496 dbSNP
rs535335808 498 dbSNP
rs1237293626 500 dbSNP
rs976432989 501 dbSNP
rs1458963281 504 dbSNP
rs565178174 505 dbSNP
rs1266934505 516 dbSNP
rs950510231 527 dbSNP
rs1354270421 531 dbSNP
rs1450146456 533 dbSNP
rs775049375 534 dbSNP
rs929762928 535 dbSNP
rs73009867 541 dbSNP
rs888302349 542 dbSNP
rs867959394 543 dbSNP
rs1453852736 546 dbSNP
rs1162193419 547 dbSNP
rs1387885673 547 dbSNP
rs941277799 549 dbSNP
rs1164962443 558 dbSNP
rs1056132612 559 dbSNP
rs1379590629 568 dbSNP
rs894455467 571 dbSNP
rs1471036272 573 dbSNP
rs1450118581 579 dbSNP
rs73507683 579 dbSNP
rs915246335 579 dbSNP
rs565491736 580 dbSNP
rs1042774685 583 dbSNP
rs1372116006 584 dbSNP
rs202003453 586 dbSNP
rs140711395 587 dbSNP
rs903259059 587 dbSNP
rs999384391 598 dbSNP
rs1374434130 600 dbSNP
rs529859148 602 dbSNP
rs1435256766 614 dbSNP
rs1304633363 619 dbSNP
rs1017157958 620 dbSNP
rs1359415869 627 dbSNP
rs1033162529 628 dbSNP
rs1156693395 632 dbSNP
rs1402401511 640 dbSNP
rs1305447512 641 dbSNP
rs898744877 650 dbSNP
rs994544755 653 dbSNP
rs1476947239 661 dbSNP
rs957800027 674 dbSNP
rs369863573 675 dbSNP
rs1487967294 677 dbSNP
rs1261145609 678 dbSNP
rs1218496437 680 dbSNP
rs1017815262 683 dbSNP
rs1278583084 686 dbSNP
rs1217806890 691 dbSNP
rs1239841714 696 dbSNP
rs1264882560 699 dbSNP
rs1347652050 702 dbSNP
rs183320358 705 dbSNP
rs1215736241 706 dbSNP
rs1009036360 708 dbSNP
rs1274094325 720 dbSNP
rs1018744046 721 dbSNP
rs1295848035 731 dbSNP
rs964476806 732 dbSNP
rs1457132260 734 dbSNP
rs112618802 735 dbSNP
rs1415327015 735 dbSNP
rs561698016 735 dbSNP
rs974546781 736 dbSNP
rs1252565350 747 dbSNP
rs1419546272 748 dbSNP
rs915193858 755 dbSNP
rs1186760785 757 dbSNP
rs968357012 765 dbSNP
rs1237397609 769 dbSNP
rs976380897 770 dbSNP
rs1366164737 783 dbSNP
rs1462880710 785 dbSNP
rs1462579526 787 dbSNP
rs536993992 789 dbSNP
rs922312738 790 dbSNP
rs1316889923 792 dbSNP
rs1293056844 798 dbSNP
rs1215799745 799 dbSNP
rs1399140215 805 dbSNP
rs552141551 811 dbSNP
rs923913877 817 dbSNP
rs929725601 822 dbSNP
rs113299987 823 dbSNP
rs1056527662 824 dbSNP
rs1337180488 830 dbSNP
rs916751794 831 dbSNP
rs948239960 832 dbSNP
rs909690139 834 dbSNP
rs1392411282 835 dbSNP
rs1429195479 835 dbSNP
rs112694173 838 dbSNP
rs1055674462 849 dbSNP
rs1198386440 851 dbSNP
rs1353618641 856 dbSNP
rs765954125 858 dbSNP
rs894403213 869 dbSNP
rs1249260674 870 dbSNP
rs1206194074 873 dbSNP
rs1307510047 875 dbSNP
rs533564703 877 dbSNP
rs1243624485 878 dbSNP
rs1384863122 885 dbSNP
rs1047406652 887 dbSNP
rs1445751250 889 dbSNP
rs886073411 893 dbSNP
rs1008652505 901 dbSNP
rs1294132477 902 dbSNP
rs1462697972 903 dbSNP
rs1018690292 909 dbSNP
rs1162734961 918 dbSNP
rs1202714714 929 dbSNP
rs1386392642 931 dbSNP
rs1252785716 939 dbSNP
rs1178636639 940 dbSNP
rs1045758001 941 dbSNP
rs553128410 948 dbSNP
rs555046014 949 dbSNP
rs1253124755 951 dbSNP
rs12984952 967 dbSNP
rs1199755517 968 dbSNP
rs754822247 969 dbSNP
rs1033523860 973 dbSNP
rs1480774123 980 dbSNP
rs574897910 986 dbSNP
rs1008149115 987 dbSNP
rs1017763059 988 dbSNP
rs1219590880 990 dbSNP
rs1361042281 991 dbSNP
rs1292400035 1009 dbSNP
rs1022065856 1013 dbSNP
rs1314850769 1018 dbSNP
rs1308905934 1021 dbSNP
rs1392139010 1026 dbSNP
rs1367145482 1027 dbSNP
rs966265685 1034 dbSNP
rs1406841604 1036 dbSNP
rs1366280251 1039 dbSNP
rs968010573 1045 dbSNP
rs978384811 1057 dbSNP
rs764992530 1059 dbSNP
rs976329945 1067 dbSNP
rs1160245816 1073 dbSNP
rs554890340 1077 dbSNP
rs960950515 1078 dbSNP
rs1196918944 1081 dbSNP
rs1422452799 1092 dbSNP
rs1490677946 1096 dbSNP
rs187860182 1098 dbSNP
rs34059821 1102 dbSNP
rs1138206 1104 dbSNP
rs916699318 1105 dbSNP
rs951136452 1124 dbSNP
rs1239490951 1126 dbSNP
rs1172096452 1128 dbSNP
rs543798201 1132 dbSNP
rs73507688 1135 dbSNP
rs909623658 1137 dbSNP
rs1281541117 1139 dbSNP
rs1462861260 1141 dbSNP
rs1038569936 1145 dbSNP
rs1302746252 1149 dbSNP
rs920062595 1150 dbSNP
rs1374247256 1158 dbSNP
rs3179532 1165 dbSNP
rs576829165 1178 dbSNP
rs1387746667 1181 dbSNP
rs141818227 1183 dbSNP
rs1465848317 1185 dbSNP
rs1427639938 1193 dbSNP
rs1173742154 1201 dbSNP
rs991311666 1202 dbSNP
rs781152627 1203 dbSNP
rs1212989177 1204 dbSNP
rs1444839852 1214 dbSNP
rs1263759344 1215 dbSNP
rs1559153 1218 dbSNP
rs1482772932 1219 dbSNP
rs1307832595 1221 dbSNP
rs1559152 1227 dbSNP
rs924605266 1232 dbSNP
rs934661794 1233 dbSNP
rs1205766727 1234 dbSNP
rs900284774 1240 dbSNP
rs1054511975 1241 dbSNP
rs893203989 1244 dbSNP
rs1138208 1245 dbSNP
rs1486644092 1251 dbSNP
rs1328341396 1252 dbSNP
rs1211523554 1257 dbSNP
rs995859645 1260 dbSNP
rs1395971314 1262 dbSNP
rs1404302782 1266 dbSNP
rs1339139328 1271 dbSNP
rs1470529347 1273 dbSNP
rs1007683528 1281 dbSNP
rs1022096919 1282 dbSNP
rs34205382 1283 dbSNP
rs1484624818 1295 dbSNP
rs548364232 1296 dbSNP
rs999450616 1297 dbSNP
rs1374307800 1314 dbSNP
rs1193753234 1318 dbSNP
rs902051070 1322 dbSNP
rs1241246013 1324 dbSNP
rs1187882782 1335 dbSNP
rs1185180001 1339 dbSNP
rs1419840463 1341 dbSNP
rs1257657524 1342 dbSNP
rs386807012 1345 dbSNP
rs201792909 1348 dbSNP
rs745620979 1348 dbSNP
rs748722037 1348 dbSNP
rs1213682035 1350 dbSNP
rs746911736 1350 dbSNP
rs796431153 1350 dbSNP
rs1212671298 1351 dbSNP
rs1491343888 1351 dbSNP
rs1559151 1351 dbSNP
rs59239281 1351 dbSNP
rs768072293 1351 dbSNP
rs1175868659 1352 dbSNP
rs564164401 1356 dbSNP
rs1407884434 1357 dbSNP
rs1397966062 1360 dbSNP
rs768347525 1364 dbSNP
rs960648016 1366 dbSNP
rs1423508530 1368 dbSNP
rs193179571 1370 dbSNP
rs997697316 1373 dbSNP
rs147208398 1375 dbSNP
rs3029143 1375 dbSNP
rs397804006 1375 dbSNP
rs1359930653 1378 dbSNP
rs1428774752 1379 dbSNP
rs1290818508 1387 dbSNP
rs1232103383 1388 dbSNP
rs1179860435 1395 dbSNP
rs1362996441 1396 dbSNP
rs1026544405 1408 dbSNP
rs1385995634 1409 dbSNP
rs951039386 1416 dbSNP
rs1004292151 1417 dbSNP
rs1016632300 1419 dbSNP
rs563377140 1437 dbSNP
rs1357460291 1444 dbSNP
rs991259414 1453 dbSNP
rs1247367520 1459 dbSNP
rs1353379037 1462 dbSNP
rs1278179041 1466 dbSNP
rs569120106 1469 dbSNP
rs538247789 1471 dbSNP
rs767396366 1480 dbSNP
rs969476934 1485 dbSNP
rs974122677 1487 dbSNP
rs147089928 1492 dbSNP
rs557919261 1495 dbSNP
rs971232276 1501 dbSNP
rs1425244679 1502 dbSNP
rs1139803 1517 dbSNP
rs981333273 1518 dbSNP
rs1242326404 1530 dbSNP
rs1156560514 1532 dbSNP
rs138245463 1535 dbSNP
rs1191370162 1537 dbSNP
rs1251484541 1539 dbSNP
rs760711725 1550 dbSNP
rs1271172218 1559 dbSNP
rs1128028 1561 dbSNP
rs534618940 1563 dbSNP
rs1054861964 1567 dbSNP
rs774737872 1570 dbSNP
rs1128029 1575 dbSNP
rs943445931 1578 dbSNP
rs1351928612 1588 dbSNP
rs1279699855 1591 dbSNP
rs1222536608 1592 dbSNP
rs1343037212 1594 dbSNP
rs1410422650 1595 dbSNP
rs539238818 1596 dbSNP
rs931740205 1597 dbSNP
rs748625007 1604 dbSNP
rs1344511551 1605 dbSNP
rs1039109966 1609 dbSNP
rs1316205147 1611 dbSNP
rs537397846 1613 dbSNP
rs557452226 1615 dbSNP
rs901998738 1616 dbSNP
rs1161445326 1622 dbSNP
rs903598899 1623 dbSNP
rs997645143 1625 dbSNP
rs1128030 1630 dbSNP
rs1128031 1631 dbSNP
rs1128032 1633 dbSNP
rs1475162488 1636 dbSNP
rs1128033 1645 dbSNP
rs184279710 1646 dbSNP
rs1006510765 1647 dbSNP
rs1128034 1648 dbSNP
rs1013483653 1653 dbSNP
rs1441419628 1656 dbSNP
rs1016991994 1657 dbSNP
rs866609595 1658 dbSNP
rs1012641228 1660 dbSNP
rs1022739188 1661 dbSNP
rs1360745383 1662 dbSNP
rs971181410 1664 dbSNP
rs1268289340 1667 dbSNP
rs1432835533 1676 dbSNP
rs974068682 1690 dbSNP
rs1335805438 1694 dbSNP
rs187913961 1698 dbSNP
rs1284272484 1700 dbSNP
rs760302467 1701 dbSNP
rs1044733 1706 dbSNP
rs1211387376 1713 dbSNP
rs1188751104 1714 dbSNP
rs990113782 1722 dbSNP
rs914531317 1735 dbSNP
rs1243110751 1741 dbSNP
rs1274720713 1748 dbSNP
rs1182108340 1752 dbSNP
rs537702629 1767 dbSNP
rs558844435 1772 dbSNP
rs912706612 1789 dbSNP
rs1264611176 1808 dbSNP
rs143494501 1811 dbSNP
rs974762224 1820 dbSNP
rs1194724521 1821 dbSNP
rs923363612 1823 dbSNP
rs933438777 1825 dbSNP
rs1232793093 1826 dbSNP
rs1450183653 1843 dbSNP
rs1384737052 1845 dbSNP
rs921606112 1846 dbSNP
rs1469000715 1854 dbSNP
rs931687619 1857 dbSNP
rs1043390771 1858 dbSNP
rs1172578478 1860 dbSNP
rs1048357422 1862 dbSNP
rs756910482 1873 dbSNP
rs866855021 1874 dbSNP
rs1385141888 1882 dbSNP
rs903627203 1882 dbSNP
rs886632218 1884 dbSNP
rs942260972 1887 dbSNP
rs1474934084 1905 dbSNP
rs541010059 1915 dbSNP
rs898139814 1921 dbSNP
rs1013513216 1926 dbSNP
rs112835479 1929 dbSNP
rs1044747 1930 dbSNP
rs192477616 1936 dbSNP
rs906949110 1939 dbSNP
rs1290866565 1969 dbSNP
rs1352551697 1973 dbSNP
rs1002648121 1997 dbSNP
rs1444248972 1999 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions TZM-bl
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM1462574. RNA binding protein: AGO2. Condition:TZM-bl ami BaL ...

- Whisnant AW; Bogerd HP; Flores O; Ho P; et al., 2013, mBio.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' gaaGACUGAGGUUCGGguca 5'
             ||||||||  |||    
Target 5' aucCUGACUCC--GCCacuu 3'
 		7 - 24
Article - Whisnant AW; Bogerd HP; Flores O; Ho P; et al.
- mBio, 2013
UNLABELLED: The question of how HIV-1 interfaces with cellular microRNA (miRNA) biogenesis and effector mechanisms has been highly controversial. Here, we first used deep sequencing of small RNAs present in two different infected cell lines (TZM-bl and C8166) and two types of primary human cells (CD4(+) peripheral blood mononuclear cells [PBMCs] and macrophages) to unequivocally demonstrate that HIV-1 does not encode any viral miRNAs. Perhaps surprisingly, we also observed that infection of T cells by HIV-1 has only a modest effect on the expression of cellular miRNAs at early times after infection. Comprehensive analysis of miRNA binding to the HIV-1 genome using the photoactivatable ribonucleoside-induced cross-linking and immunoprecipitation (PAR-CLIP) technique revealed several binding sites for cellular miRNAs, a subset of which were shown to be capable of mediating miRNA-mediated repression of gene expression. However, the main finding from this analysis is that HIV-1 transcripts are largely refractory to miRNA binding, most probably due to extensive viral RNA secondary structure. Together, these data demonstrate that HIV-1 neither encodes viral miRNAs nor strongly influences cellular miRNA expression, at least early after infection, and imply that HIV-1 transcripts have evolved to avoid inhibition by preexisting cellular miRNAs by adopting extensive RNA secondary structures that occlude most potential miRNA binding sites. IMPORTANCE: MicroRNAs (miRNAs) are a ubiquitous class of small regulatory RNAs that serve as posttranscriptional regulators of gene expression. Previous work has suggested that HIV-1 might subvert the function of the cellular miRNA machinery by expressing viral miRNAs or by dramatically altering the level of cellular miRNA expression. Using very sensitive approaches, we now demonstrate that neither of these ideas is in fact correct. Moreover, HIV-1 transcripts appear to largely avoid regulation by cellular miRNAs by adopting an extensive RNA secondary structure that occludes the ability of cellular miRNAs to interact with viral mRNAs. Together, these data suggest that HIV-1, rather than seeking to control miRNA function in infected cells, has instead evolved a mechanism to become largely invisible to cellular miRNA effector mechanisms.
LinkOut: [PMID: 23592263]
CLIP-seq Support 1 for dataset GSM4903833
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / CTL_TD_21_a
Location of target site NM_032285 | 3UTR | GAGGAUGGCUUGAGCCCAG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM4903835
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / CTL_TD_21_c
Location of target site NM_001031727 | 3UTR | GGCUUGAGCCCAGGA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 3 for dataset GSM4903837
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / 124_TD_21_b
Location of target site NM_001031727 | 3UTR | CCCAGAUUCAAAUCCUGACUCCGCCACUUUUCCCACUGUAUGAUCUU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 4 for dataset GSM1462574
Method / RBP PAR-CLIP / AGO2
Cell line / Condition TZM-bl / TZM-bl ami BaL
Location of target site ENST00000319545.8 | 3UTR | AUUCAAAUCCUGACUCCGCCACUUUUCCCACUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23592263 / GSE59944
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
68 hsa-miR-378g Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT444739 SMYD1 SET and MYND domain containing 1 2 2
MIRT456104 VAV3 vav guanine nucleotide exchange factor 3 2 4
MIRT458683 MRI1 methylthioribose-1-phosphate isomerase 1 2 2
MIRT465802 TMEM91 transmembrane protein 91 2 2
MIRT470843 PLXND1 plexin D1 2 2
MIRT497263 GRK6 G protein-coupled receptor kinase 6 2 2
MIRT497674 SYNGR1 synaptogyrin 1 2 2
MIRT498218 TLN2 talin 2 2 2
MIRT498309 BCL11B B-cell CLL/lymphoma 11B 2 2
MIRT504046 TOMM5 translocase of outer mitochondrial membrane 5 2 2
MIRT518196 CLEC4E C-type lectin domain family 4 member E 2 2
MIRT533143 WNT10A Wnt family member 10A 2 2
MIRT533540 TPR translocated promoter region, nuclear basket protein 2 2
MIRT533679 TMEM86A transmembrane protein 86A 2 2
MIRT540892 SRSF9 serine and arginine rich splicing factor 9 2 2
MIRT541329 G3BP1 G3BP stress granule assembly factor 1 2 2
MIRT541850 PLIN5 perilipin 5 2 2
MIRT551431 F2 coagulation factor II, thrombin 2 2
MIRT552105 PPP1R1A protein phosphatase 1 regulatory inhibitor subunit 1A 2 2
MIRT564912 YTHDF1 YTH N6-methyladenosine RNA binding protein 1 2 2
MIRT568605 ACVR2A activin A receptor type 2A 2 2
MIRT572604 PAPLN papilin, proteoglycan like sulfated glycoprotein 2 2
MIRT574234 DMRT2 doublesex and mab-3 related transcription factor 2 2 2
MIRT575688 Map1b microtubule-associated protein 1B 2 2
MIRT576643 Mill2 MHC I like leukocyte 2 1 1
MIRT609877 RAD54L2 RAD54 like 2 2 4
MIRT610057 MYBPC1 myosin binding protein C, slow type 2 2
MIRT610791 KLK2 kallikrein related peptidase 2 2 2
MIRT617175 GOSR2 golgi SNAP receptor complex member 2 2 2
MIRT617707 RUSC2 RUN and SH3 domain containing 2 2 2
MIRT620577 WBSCR27 methyltransferase like 27 2 4
MIRT622657 POU2F3 POU class 2 homeobox 3 2 4
MIRT624561 BDP1 B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB 2 2
MIRT634255 TIAL1 TIA1 cytotoxic granule associated RNA binding protein like 1 2 2
MIRT634677 GDE1 glycerophosphodiester phosphodiesterase 1 2 2
MIRT635254 FBXL20 F-box and leucine rich repeat protein 20 2 2
MIRT637081 SELPLG selectin P ligand 2 2
MIRT639021 AAK1 AP2 associated kinase 1 2 2
MIRT640396 ZNF785 zinc finger protein 785 2 2
MIRT642441 CLUAP1 clusterin associated protein 1 2 2
MIRT645666 ADK adenosine kinase 2 2
MIRT646083 MGST3 microsomal glutathione S-transferase 3 2 2
MIRT650513 UFM1 ubiquitin fold modifier 1 2 2
MIRT652474 TMEM181 transmembrane protein 181 2 2
MIRT652584 TIMM8A translocase of inner mitochondrial membrane 8A 2 2
MIRT654763 PRKAR2A protein kinase cAMP-dependent type II regulatory subunit alpha 2 2
MIRT655200 PHAX phosphorylated adaptor for RNA export 2 2
MIRT658353 FAM65B RHO family interacting cell polarization regulator 2 2 2
MIRT661820 PRPSAP1 phosphoribosyl pyrophosphate synthetase associated protein 1 2 2
MIRT662190 MEI1 meiotic double-stranded break formation protein 1 2 2
MIRT664375 CYB5A cytochrome b5 type A 2 2
MIRT665025 ELK1 ELK1, ETS transcription factor 2 2
MIRT666492 SBNO1 strawberry notch homolog 1 2 2
MIRT668480 EXOSC2 exosome component 2 2 2
MIRT682768 TMEM120B transmembrane protein 120B 2 2
MIRT689628 NAA30 N(alpha)-acetyltransferase 30, NatC catalytic subunit 2 2
MIRT691846 OSCAR osteoclast associated, immunoglobulin-like receptor 2 2
MIRT696490 COX6B1 cytochrome c oxidase subunit 6B1 2 2
MIRT712480 FSTL3 follistatin like 3 2 2
MIRT712780 ZNF154 zinc finger protein 154 2 2
MIRT716607 MPPED1 metallophosphoesterase domain containing 1 2 2
MIRT719357 ITPKB inositol-trisphosphate 3-kinase B 2 2
MIRT719739 SLC39A11 solute carrier family 39 member 11 2 2
MIRT722569 C1orf95 stum, mechanosensory transduction mediator homolog 2 2
MIRT722838 C17orf102 chromosome 17 open reading frame 102 2 2
MIRT733138 LINC00963 long intergenic non-protein coding RNA 963 3 0
MIRT733139 CHI3L1 chitinase 3 like 1 3 0
MIRT736944 TARBP2 TARBP2, RISC loading complex RNA binding subunit 2 0
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-378g Fluorouracil 3385 NSC19893 approved resistant High Pancreatic Cancer cell line (PANC-1)
hsa-miR-378g Gemcitabine 60750 NSC613327 approved resistant High Pancreatic Cancer cell line (PANC-1)
hsa-miR-378g Vemurafenib 42611257 NSC761431 approved sensitive High Melanoma cell line (A375, IGR37, 501Mel)
hsa-miR-378g Dabrafenib 44462760 NSC764134 approved sensitive High Melanoma cell line (A375, IGR37, 501Mel)
hsa-miR-378g Trametinib 11707110 NSC758246 approved resistant High Melanoma cell line (WM266) (1uM)
hsa-miR-378g Vemurafenib 42611257 NSC761431 approved resistant High Melanoma cell line (WM266) (1uM)
hsa-miR-378g Trametinib 11707110 NSC758246 approved resistant High Melanoma cell line (WM266) (500nM)
hsa-miR-378g Vemurafenib 42611257 NSC761431 approved resistant High Melanoma cell line (WM266) (500nM)
hsa-miR-378g Vemurafenib 42611257 NSC761431 approved resistant High Melanoma cell line (WM266) (2uM)
hsa-miR-378g Trametinib 11707110 NSC758246 approved resistant High Melanoma cell line (WM266) (2uM)
hsa-miR-378g Gemcitabine 60750 NSC613327 approved sensitive High Pancreatic Cancer cell line (AsPC-1)
hsa-miR-378g Trametinib 11707110 NSC758246 approved sensitive High Melanoma cell line
hsa-miR-378g Vemurafenib 42611257 NSC761431 approved sensitive High Melanoma cell line
hsa-miR-378g Dabrafenib + Trametinib sensitive High Melanoma cell line
hsa-miR-378g Dabrafenib 44462760 NSC764134 approved sensitive High Melanoma cell line
hsa-mir-378g Decitabine 451668 approved sensitive tissue (esopheageal cancer)
hsa-miR-378g Temozolomide 5394 NSC362856 approved resistant cell line (U251)
hsa-miR-378g Gefitinib 123631 NSC715055 approved resistant cell line (HCC827)
hsa-miR-378g Osimertinib 71496458 NSC779217 approved sensitive cell line (PC9)
hsa-miR-378g Osimertinib 71496458 NSC779217 approved resistant cell line (HCC827)
hsa-miR-378g Tripterygium wilfordii Hook F resistant tissue
hsa-miR-378g Vemurafenib 42611257 NSC761431 approved sensitive cell line (LM17)
hsa-miR-378g Vemurafenib 42611257 NSC761431 approved sensitive cell line (LM36)
hsa-miR-378g Vemurafenib 42611257 NSC761431 approved sensitive cell line (LM16)
hsa-miR-378g Paclitaxel 36314 NSC125973 approved sensitive cell line (BAS)
hsa-miR-378g Doxorubicin 31703 NSC123127 approved sensitive cell line (BAS)
hsa-miR-378g Neoadjuvant chemotherapy resistant tissue (breast cancer)
hsa-miR-378g Gemcitabine 60750 NSC613327 approved resistant cell line (Panc1-GR3)
hsa-miR-378g Gemcitabine 60750 NSC613327 approved resistant cell line (Panc1-GR4)

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