miRTarBase - #MIRT458923


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pre-miRNA Information
pre-miRNA hsa-mir-4436b-1   
Genomic Coordinates chr2: 110086433 - 110086523
Description Homo sapiens miR-4436b-1 stem-loop
Comment None
RNA Secondary Structure
pre-miRNA hsa-mir-4436b-2   
Genomic Coordinates chr2: 110284853 - 110284943
Description Homo sapiens miR-4436b-2 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-4436b-3p
Sequence 60| CAGGGCAGGAAGAAGUGGACAA |81
Evidence Experimental
Experiments Illumina
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs760150076 9 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol DNM2   
Synonyms CMT2M, CMTDI1, CMTDIB, DI-CMTB, DYN2, DYNII, LCCS5
Description dynamin 2
Transcript NM_001005360   
Other Transcripts NM_001005361 , NM_001005362 , NM_001190716 , NM_004945   
Expression
Putative miRNA Targets on DNM2
3'UTR of DNM2
(miRNA target sites are highlighted)		 
>DNM2|NM_001005360|3'UTR
   1 GCCTCGAGGGGGGCGTGCTCTCGGGGGGGCCTCACGCACCCGCGGCGCAGGAGCTTCAGTGGTCTGGGGCCCTCCGCCGC
  81 CCCTATGCTGGGACCAGGCTCCCAGTGGGCAGCCCTGGCCTCTTCCTTAACGCTGGCCCCGGTCCAGGGCCGGCCCCTGT
 161 GCCTGGCTGGACACCGCACTGCGCAAAGGGGCCCTGGAGCTCCAGGCAGGGGGCGCTGGGGTGTTGCACTTTGGGGGATG
 241 GAGTCTCAGGGTGGCAGAGGGGGGACCAGAACCCTTGACACCATCCTGAATGAGGGGTCCAGCCTGGGGGGGACTCTACC
 321 AAGGTCTTCTTGGGCTGGGAAAGCCCATGTAGGGCAGGCCTTCTATAAGTGCGGGCACCAAGGGCGCCTACATCCCCAGG
 401 CCTTGCTGGGGTGCAGGGGTATATCAACTTCCCATTAGCAGGAGCTCCCCAGCGGCAAGCCTGGCCCAGTGGGCTCGGTA
 481 GTGCCCAGCTGGCAGGCCTGAGGTGTACATAGTCCTTCCCGGCCATATTAACCACACAGCCTGAGCCTGGCCCAGCCTCG
 561 GCTGCCAGAGGTGCCTTTGCTAGGCCCGGAGCCGTTGGCCCGGGCCGGCCTTGCCCTATTCCTCTCCTCCTCCTCCTCCT
 641 GGGTCCCCCAGGGTGGCTGGGCTTGGGCTATGTGGGTGGTGGTGGCGGGGGGTCTTGGGGGCCTCTCAGCTCCCGCCCAT
 721 GCCTCCCTGATGGGTGGGCCCAGGGCGGCCTCTCTCTGAGGAGACCTCACCCACTCCTCGCTCAGTTTGACCACTGTAAG
 801 TGCCTGCACTCTGTATTCTATTAATAAACTAAAATAAAGGGAAGACGCTGCTGGTGGCTGCTGAAAAAAAAAAAAAAAAA
 881 A
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' aacaggugaagaaGGACGGGAc 5'
                       |:|||||| 
Target 5' ggcccgggccggcCTTGCCCTa 3'
 597 - 618 129.00 -14.30
2 
miRNA  3' aaCAGGUGAAG---AAGGACGGGAc 5'
            | ||||| :   | ||||| || 
Target 5' ttGACCACTGTAAGTGCCTGCACTc 3'
 787 - 811 128.00 -15.40
3 
miRNA  3' aacaggugaagaaGGACGGGAc 5'
                       |||| ||| 
Target 5' cccagtgggcagcCCTGGCCTc 3'
 101 - 122 113.00 -13.20
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
327994 11 ClinVar
327995 15 ClinVar
327996 23 ClinVar
327997 23 ClinVar
327998 36 ClinVar
327999 48 ClinVar
328000 80 ClinVar
328001 83 ClinVar
328002 89 ClinVar
328003 107 ClinVar
328004 167 ClinVar
890632 186 ClinVar
890633 215 ClinVar
328005 269 ClinVar
328006 306 ClinVar
891183 322 ClinVar
891184 374 ClinVar
891185 380 ClinVar
328007 386 ClinVar
328008 387 ClinVar
328009 392 ClinVar
328010 454 ClinVar
328011 551 ClinVar
328012 602 ClinVar
328013 608 ClinVar
888990 672 ClinVar
328014 712 ClinVar
889678 717 ClinVar
889679 752 ClinVar
COSN26973882 6 COSMIC
COSN26961441 11 COSMIC
COSN30632093 14 COSMIC
COSN24306841 15 COSMIC
COSN30542940 23 COSMIC
COSN30612657 30 COSMIC
COSN30680435 30 COSMIC
COSN31592490 31 COSMIC
COSN31537999 36 COSMIC
COSN31603857 47 COSMIC
COSN21178371 165 COSMIC
COSN17432223 269 COSMIC
COSN31522090 333 COSMIC
COSN22706451 364 COSMIC
COSN9225751 366 COSMIC
COSN1210591 470 COSMIC
COSN31518669 512 COSMIC
COSN24306503 523 COSMIC
COSN30171077 594 COSMIC
COSN31566491 732 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs201492679 2 dbSNP
rs775783187 6 dbSNP
rs376586174 7 dbSNP
rs758093165 8 dbSNP
rs777372720 8 dbSNP
rs764535055 9 dbSNP
rs761890287 10 dbSNP
rs200188660 11 dbSNP
rs1176295272 13 dbSNP
rs750490287 14 dbSNP
rs369529119 15 dbSNP
rs1335579045 16 dbSNP
rs531170486 23 dbSNP
rs575649173 23 dbSNP
rs886054142 23 dbSNP
rs751358047 24 dbSNP
rs373530994 26 dbSNP
rs781021684 27 dbSNP
rs752613834 28 dbSNP
rs755694820 29 dbSNP
rs970475202 30 dbSNP
rs981814157 32 dbSNP
rs199700849 36 dbSNP
rs770527645 37 dbSNP
rs778582014 42 dbSNP
rs201756628 43 dbSNP
rs769002287 44 dbSNP
rs989414116 45 dbSNP
rs777139746 46 dbSNP
rs528790280 47 dbSNP
rs367938944 48 dbSNP
rs968305088 52 dbSNP
rs978845697 59 dbSNP
rs1249056279 61 dbSNP
rs1211059522 62 dbSNP
rs1333337350 63 dbSNP
rs1468329062 66 dbSNP
rs922577935 69 dbSNP
rs1356494781 70 dbSNP
rs112740866 71 dbSNP
rs868810675 77 dbSNP
rs535532078 79 dbSNP
rs550692861 80 dbSNP
rs1407126554 81 dbSNP
rs569502521 83 dbSNP
rs1406008350 86 dbSNP
rs886054143 89 dbSNP
rs537301543 93 dbSNP
rs1391947242 95 dbSNP
rs1460733493 100 dbSNP
rs558479379 104 dbSNP
rs897439830 105 dbSNP
rs1449102128 106 dbSNP
rs886054144 107 dbSNP
rs1190898695 128 dbSNP
rs761155589 132 dbSNP
rs369969282 133 dbSNP
rs970337946 134 dbSNP
rs919181416 137 dbSNP
rs1003264351 138 dbSNP
rs1033349352 141 dbSNP
rs778564338 142 dbSNP
rs1297965296 144 dbSNP
rs1230324430 146 dbSNP
rs1337187799 148 dbSNP
rs577028326 150 dbSNP
rs930545872 151 dbSNP
rs915073925 152 dbSNP
rs967051310 153 dbSNP
rs1326935703 157 dbSNP
rs745381074 160 dbSNP
rs886054145 167 dbSNP
rs1371385791 173 dbSNP
rs1439370005 175 dbSNP
rs1278510516 176 dbSNP
rs1356644332 177 dbSNP
rs766892707 183 dbSNP
rs1192235109 185 dbSNP
rs570774479 186 dbSNP
rs933942126 189 dbSNP
rs1247880853 211 dbSNP
rs1202402796 213 dbSNP
rs1271831719 215 dbSNP
rs558027044 216 dbSNP
rs1196765200 221 dbSNP
rs545436079 222 dbSNP
rs1310180147 224 dbSNP
rs1049849859 226 dbSNP
rs1219665665 227 dbSNP
rs1056500620 233 dbSNP
rs1181171979 236 dbSNP
rs1229320471 240 dbSNP
rs1238185600 248 dbSNP
rs1351227573 258 dbSNP
rs759626404 261 dbSNP
rs911330676 262 dbSNP
rs12461992 269 dbSNP
rs1189896737 284 dbSNP
rs1415623619 286 dbSNP
rs1358892062 294 dbSNP
rs1177253133 306 dbSNP
rs886054146 306 dbSNP
rs191330227 307 dbSNP
rs1416582417 308 dbSNP
rs1406409205 309 dbSNP
rs1474730629 311 dbSNP
rs897308834 313 dbSNP
rs1168333665 317 dbSNP
rs149937994 322 dbSNP
rs1183837355 326 dbSNP
rs534332355 328 dbSNP
rs1021091089 331 dbSNP
rs904110921 349 dbSNP
rs1327781087 351 dbSNP
rs1001084182 353 dbSNP
rs1313787865 365 dbSNP
rs1028990265 366 dbSNP
rs1266131561 366 dbSNP
rs1024032256 373 dbSNP
rs906210543 374 dbSNP
rs953057550 380 dbSNP
rs1450612658 381 dbSNP
rs1343848068 382 dbSNP
rs1291919776 384 dbSNP
rs78160240 386 dbSNP
rs74952080 387 dbSNP
rs886054147 392 dbSNP
rs1272358310 393 dbSNP
rs1412586595 394 dbSNP
rs1337684404 412 dbSNP
rs1010634319 414 dbSNP
rs1484089222 416 dbSNP
rs1245984227 418 dbSNP
rs1207968251 422 dbSNP
rs780967653 424 dbSNP
rs972315818 428 dbSNP
rs746714638 429 dbSNP
rs575248424 432 dbSNP
rs919059969 436 dbSNP
rs1321249519 440 dbSNP
rs1313674425 448 dbSNP
rs1230276305 452 dbSNP
rs200104482 454 dbSNP
rs922480697 455 dbSNP
rs1436361412 460 dbSNP
rs1391451362 476 dbSNP
rs955268952 477 dbSNP
rs182644552 478 dbSNP
rs938035448 479 dbSNP
rs1164973916 480 dbSNP
rs528752597 482 dbSNP
rs1255294667 489 dbSNP
rs1425199567 492 dbSNP
rs911208517 497 dbSNP
rs941472119 499 dbSNP
rs1449910599 500 dbSNP
rs1249793335 503 dbSNP
rs974156473 512 dbSNP
rs918769725 514 dbSNP
rs930104899 516 dbSNP
rs1374520758 518 dbSNP
rs540550675 521 dbSNP
rs1223982185 522 dbSNP
rs1340293635 527 dbSNP
rs1297211052 533 dbSNP
rs907497428 534 dbSNP
rs937590462 537 dbSNP
rs1042953129 538 dbSNP
rs1166913982 550 dbSNP
rs886054148 551 dbSNP
rs561728898 553 dbSNP
rs539454672 560 dbSNP
rs529286909 561 dbSNP
rs1011093691 571 dbSNP
rs1426082915 572 dbSNP
rs550660987 588 dbSNP
rs1022008763 589 dbSNP
rs1374619574 590 dbSNP
rs902357169 594 dbSNP
rs999395316 595 dbSNP
rs1268069190 597 dbSNP
rs185820576 602 dbSNP
rs1320869366 603 dbSNP
rs1007247015 607 dbSNP
rs117954916 608 dbSNP
rs1344695743 610 dbSNP
rs985381014 618 dbSNP
rs1350389148 623 dbSNP
rs1304127111 624 dbSNP
rs971881209 624 dbSNP
rs780011638 625 dbSNP
rs1026476878 631 dbSNP
rs1232144387 633 dbSNP
rs1018705374 637 dbSNP
rs962718612 639 dbSNP
rs1306984993 641 dbSNP
rs1486241462 644 dbSNP
rs1205573627 652 dbSNP
rs1263799992 661 dbSNP
rs190696940 672 dbSNP
rs918643646 673 dbSNP
rs959251065 674 dbSNP
rs542631620 676 dbSNP
rs917877106 677 dbSNP
rs1251200565 684 dbSNP
rs981612915 684 dbSNP
rs945367010 685 dbSNP
rs1254413700 687 dbSNP
rs753331843 687 dbSNP
rs928787507 687 dbSNP
rs1455358566 688 dbSNP
rs1042510018 689 dbSNP
rs905176240 694 dbSNP
rs570576980 697 dbSNP
rs1258254167 701 dbSNP
rs1227125519 711 dbSNP
rs886054149 712 dbSNP
rs1326407243 716 dbSNP
rs937621414 723 dbSNP
rs1056020668 732 dbSNP
rs1337163502 733 dbSNP
rs1331843650 739 dbSNP
rs894808907 740 dbSNP
rs534897506 744 dbSNP
rs1455588669 745 dbSNP
rs1411248491 747 dbSNP
rs936873220 748 dbSNP
rs1160759313 750 dbSNP
rs1366912296 750 dbSNP
rs1471233305 750 dbSNP
rs1057884 757 dbSNP
rs1443315685 758 dbSNP
rs1043777801 759 dbSNP
rs1207324782 761 dbSNP
rs1383470648 776 dbSNP
rs902304784 780 dbSNP
rs1228446144 781 dbSNP
rs1057886 794 dbSNP
rs553338764 795 dbSNP
rs1327044696 797 dbSNP
rs1352262320 797 dbSNP
rs1243635866 798 dbSNP
rs1050322900 799 dbSNP
rs999259246 807 dbSNP
rs1029531956 819 dbSNP
rs868403259 825 dbSNP
rs1387801208 831 dbSNP
rs1438902934 840 dbSNP
rs77603768 841 dbSNP
rs535393826 845 dbSNP
rs557005694 847 dbSNP
rs1008445844 848 dbSNP
rs1387399493 855 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions TZM-bl
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM1462574. RNA binding protein: AGO2. Condition:TZM-bl ami BaL ...

- Whisnant AW; Bogerd HP; Flores O; Ho P; et al., 2013, mBio.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' aacagguGAAGAAGGACGGGAc 5'
                 | | ||||| :||| 
Target 5' ------cCCUAUUCCUCUCCUc 3'
 		1 - 16
Article - Whisnant AW; Bogerd HP; Flores O; Ho P; et al.
- mBio, 2013
UNLABELLED: The question of how HIV-1 interfaces with cellular microRNA (miRNA) biogenesis and effector mechanisms has been highly controversial. Here, we first used deep sequencing of small RNAs present in two different infected cell lines (TZM-bl and C8166) and two types of primary human cells (CD4(+) peripheral blood mononuclear cells [PBMCs] and macrophages) to unequivocally demonstrate that HIV-1 does not encode any viral miRNAs. Perhaps surprisingly, we also observed that infection of T cells by HIV-1 has only a modest effect on the expression of cellular miRNAs at early times after infection. Comprehensive analysis of miRNA binding to the HIV-1 genome using the photoactivatable ribonucleoside-induced cross-linking and immunoprecipitation (PAR-CLIP) technique revealed several binding sites for cellular miRNAs, a subset of which were shown to be capable of mediating miRNA-mediated repression of gene expression. However, the main finding from this analysis is that HIV-1 transcripts are largely refractory to miRNA binding, most probably due to extensive viral RNA secondary structure. Together, these data demonstrate that HIV-1 neither encodes viral miRNAs nor strongly influences cellular miRNA expression, at least early after infection, and imply that HIV-1 transcripts have evolved to avoid inhibition by preexisting cellular miRNAs by adopting extensive RNA secondary structures that occlude most potential miRNA binding sites. IMPORTANCE: MicroRNAs (miRNAs) are a ubiquitous class of small regulatory RNAs that serve as posttranscriptional regulators of gene expression. Previous work has suggested that HIV-1 might subvert the function of the cellular miRNA machinery by expressing viral miRNAs or by dramatically altering the level of cellular miRNA expression. Using very sensitive approaches, we now demonstrate that neither of these ideas is in fact correct. Moreover, HIV-1 transcripts appear to largely avoid regulation by cellular miRNAs by adopting an extensive RNA secondary structure that occludes the ability of cellular miRNAs to interact with viral mRNAs. Together, these data suggest that HIV-1, rather than seeking to control miRNA function in infected cells, has instead evolved a mechanism to become largely invisible to cellular miRNA effector mechanisms.
LinkOut: [PMID: 23592263]
CLIP-seq Support 1 for dataset GSM1462574
Method / RBP PAR-CLIP / AGO2
Cell line / Condition TZM-bl / TZM-bl ami BaL
Location of target site ENST00000314646.5 | 3UTR | CCCUAUUCCUCUCCUCCUCCUCCUCCUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23592263 / GSE59944
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
87 hsa-miR-4436b-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT066957 ATXN7L3B ataxin 7 like 3B 2 8
MIRT119284 NABP1 nucleic acid binding protein 1 2 6
MIRT128915 KMT2A lysine methyltransferase 2A 2 2
MIRT150116 MIDN midnolin 2 2
MIRT173040 YTHDF3 YTH N6-methyladenosine RNA binding protein 3 2 2
MIRT253117 BCL2L12 BCL2 like 12 2 2
MIRT256997 RGMB repulsive guidance molecule family member b 2 2
MIRT259746 SNX12 sorting nexin 12 2 2
MIRT267278 TMEM109 transmembrane protein 109 2 2
MIRT441934 C1orf109 chromosome 1 open reading frame 109 2 2
MIRT443625 CPSF2 cleavage and polyadenylation specific factor 2 2 2
MIRT445757 AGO1 argonaute 1, RISC catalytic component 2 2
MIRT447835 CTIF cap binding complex dependent translation initiation factor 2 2
MIRT451230 ZNF444 zinc finger protein 444 2 2
MIRT451966 TMPRSS5 transmembrane protease, serine 5 2 2
MIRT453127 HOXC4 homeobox C4 2 2
MIRT454604 RPL13A ribosomal protein L13a 2 2
MIRT455176 SUV39H1 suppressor of variegation 3-9 homolog 1 2 2
MIRT455547 GJB1 gap junction protein beta 1 2 2
MIRT458197 ATP6V0A2 ATPase H+ transporting V0 subunit a2 2 2
MIRT458356 NOC2L NOC2 like nucleolar associated transcriptional repressor 2 2
MIRT458923 DNM2 dynamin 2 2 2
MIRT461013 SYT7 synaptotagmin 7 2 2
MIRT461643 ZSWIM4 zinc finger SWIM-type containing 4 2 2
MIRT461997 PACSIN1 protein kinase C and casein kinase substrate in neurons 1 2 2
MIRT462367 BCL7B BCL tumor suppressor 7B 2 2
MIRT464915 TXNIP thioredoxin interacting protein 2 2
MIRT466311 TIMM22 translocase of inner mitochondrial membrane 22 2 2
MIRT466591 TBC1D2B TBC1 domain family member 2B 2 2
MIRT467045 SRSF1 serine and arginine rich splicing factor 1 2 2
MIRT468750 SDC2 syndecan 2 2 2
MIRT468943 RPS24 ribosomal protein S24 2 2
MIRT469474 REEP5 receptor accessory protein 5 2 2
MIRT469913 PTRF caveolae associated protein 1 2 2
MIRT473325 MEX3A mex-3 RNA binding family member A 2 2
MIRT473643 MARK2 microtubule affinity regulating kinase 2 2 2
MIRT474064 LMNB2 lamin B2 2 2
MIRT474357 KMT2D lysine methyltransferase 2D 2 2
MIRT475394 ICMT isoprenylcysteine carboxyl methyltransferase 2 4
MIRT476335 GLTSCR1L BRD4 interacting chromatin remodeling complex associated protein like 2 2
MIRT478651 CTDNEP1 CTD nuclear envelope phosphatase 1 2 2
MIRT479585 CDC42SE1 CDC42 small effector 1 2 2
MIRT479943 CBX5 chromobox 5 2 2
MIRT482001 AMOTL2 angiomotin like 2 2 2
MIRT482043 AMER1 APC membrane recruitment protein 1 2 2
MIRT483070 EXT2 exostosin glycosyltransferase 2 2 6
MIRT484323 KCNH1 potassium voltage-gated channel subfamily H member 1 2 4
MIRT487528 GXYLT2 glucoside xylosyltransferase 2 2 2
MIRT489636 ALS2CL ALS2 C-terminal like 2 2
MIRT490693 SSTR1 somatostatin receptor 1 2 2
MIRT490871 UPK2 uroplakin 2 2 2
MIRT492582 PPM1L protein phosphatase, Mg2+/Mn2+ dependent 1L 2 2
MIRT492945 NEUROD2 neuronal differentiation 2 2 2
MIRT498675 SOD2 superoxide dismutase 2 2 4
MIRT499349 RAB25 RAB25, member RAS oncogene family 2 2
MIRT502338 GIGYF1 GRB10 interacting GYF protein 1 2 4
MIRT502976 CCNL1 cyclin L1 2 8
MIRT503706 NUP62 nucleoporin 62 2 2
MIRT505567 SMUG1 single-strand-selective monofunctional uracil-DNA glycosylase 1 2 2
MIRT507808 CDKN1B cyclin dependent kinase inhibitor 1B 2 2
MIRT513242 FBXO41 F-box protein 41 2 6
MIRT513586 EVX1 even-skipped homeobox 1 2 2
MIRT525036 FRK fyn related Src family tyrosine kinase 2 2
MIRT531035 TDGF1P3 teratocarcinoma-derived growth factor 1 pseudogene 3 2 2
MIRT531939 RBMS2 RNA binding motif single stranded interacting protein 2 2 2
MIRT534912 PUM2 pumilio RNA binding family member 2 2 2
MIRT535717 N4BP1 NEDD4 binding protein 1 2 2
MIRT540498 ZMAT4 zinc finger matrin-type 4 2 4
MIRT541465 AURKA aurora kinase A 2 2
MIRT554328 SH3GLB1 SH3 domain containing GRB2 like, endophilin B1 2 2
MIRT561572 SLC6A9 solute carrier family 6 member 9 2 2
MIRT564715 ZNF322P1 zinc finger protein 322 pseudogene 1 2 2
MIRT576176 Hmox1 heme oxygenase 1 2 2
MIRT629712 XKR4 XK related 4 2 2
MIRT636182 THBD thrombomodulin 2 2
MIRT646315 MPHOSPH8 M-phase phosphoprotein 8 2 2
MIRT649174 IQSEC1 IQ motif and Sec7 domain 1 2 2
MIRT666945 PMEPA1 prostate transmembrane protein, androgen induced 1 2 2
MIRT684057 FOLR1 folate receptor 1 2 2
MIRT687585 MAU2 MAU2 sister chromatid cohesion factor 2 2
MIRT689953 ZNF185 zinc finger protein 185 with LIM domain 2 2
MIRT704071 SRCAP Snf2 related CREBBP activator protein 2 2
MIRT704327 DCUN1D5 defective in cullin neddylation 1 domain containing 5 2 2
MIRT705406 ATP1B3 ATPase Na+/K+ transporting subunit beta 3 2 2
MIRT710488 CDH5 cadherin 5 2 2
MIRT718241 LCE1A late cornified envelope 1A 2 2
MIRT723182 CDCA4 cell division cycle associated 4 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-4436b-3p Gefitinib 123631 NSC715055 approved resistant cell line (HCC827)
hsa-miR-4436b-3p Gemcitabine 60750 NSC613327 approved resistant cell line (Panc1-GR4)

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