miRTarBase - #MIRT459066


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pre-miRNA Information
pre-miRNA hsa-mir-4640   
Genomic Coordinates chr6: 30890883 - 30890972
Description Homo sapiens miR-4640 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-4640-5p
Sequence 9| UGGGCCAGGGAGCAGCUGGUGGG |31
Evidence Experimental
Experiments Illumina
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1392105945 7 dbSNP
rs939712790 9 dbSNP
rs762825841 15 dbSNP
rs71552023 20 dbSNP
rs1305909531 21 dbSNP
rs750017220 21 dbSNP
rs1375436057 23 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
Circulating MicroRNA Expression Profiling
Biomarker Information
Biomarker ID Name Type Discovered From Mode Level Source Testing Methods
B32FZJ miR-4640 Safety Biomarker (SAF) Clinical/Experimental Data Expression lower Urine Quantitative polymerase chain reaction
Gene Information
Gene Symbol WFIKKN2   
Synonyms GASP-1, WFDC20B, WFIKKNRP, hGASP-1
Description WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2
Transcript NM_175575   
Expression
Putative miRNA Targets on WFIKKN2
3'UTR of WFIKKN2
(miRNA target sites are highlighted)		 
>WFIKKN2|NM_175575|3'UTR
   1 AGCCCCCCACCCCTCCCTGCCCCCTCCCTGGCCTTCTTCCACCTATCCACCCCAATGCCTCTCAGCAAACTGGGCGAGGT
  81 CAGATTAGACAGGCTTGGGACAGCAGGGAAACATCAACCGACGTGTCACAGAAAAAGCCACAGAAGGTCTCAGATCAGCA
 161 TCTATTCTTTGGGTTCAATAAGGGGTTCATATCTTTTTTAGCTGAGGGGGACAAGAGGAGAAGTCAGTGGACACATGGAA
 241 GTTACTCGTGACCACCAGCTTGCTCAGATATTCTCCTCCTCCCCTCACTGGCCCCACACCCCTGGCTCTCCCAGTCACCC
 321 TCCCCTAGCCAGTCTCCCAGCAAGGGTTTAAGAGATGGCCGCTGTGTGCTGGTCACAGGAAGTGTTGAATGGATTGGCTT
 401 GCAAAGGGGGTAGGTGGGGAGAGATAGGAGGGCCCAGGGACTCATGGGACACCTTTCCCACAGCCTCCTCGATTGCTGTG
 481 AGCAGAGGCCACTCGGAGTTAGGGGCATGGGCAATAGCAAGCTGGCGGCAGAGTCCAGCCCAGCATATGACTTGCCCTGA
 561 ATGGAAGCTGCTGAAACGGGTGCCTTTGGGTGGTGGTCGGCTTGCCTCTGAGGCCACCACGGCACCAGCAGAATACGTAT
 641 TTCTTCTCCTTGGCTGCACTGGTTTGTCGATCTAGTTCAGTTCAACTCAGTGGATGTTCTCTGAATGCTTACTGGGTGCC
 721 AGGACCACAGAGAGATGTTAGTCACTGCCCAGTTCTTAGAGCCCCAACACAGATACCCTCATCCCAGGGCCCCCAGACAC
 801 ACCCCTCCGCTGGACTCACAACTGTCTGGAGTTTCTGTCTGATGGATGGTGTGCTTTCATATGCCACTGGCTTCCTTGGA
 881 CATAGATCAGACAAAAGCCCCGGGATCTGTTTGGTAGCAGGAGAAATGAAGGAAGATGAAAAAGCAGGCAGGGAAGGGGG
 961 TAGTAAAGGACTGAGAGAGGAGGGAGGTGGCTGGAGAAGGAAAAGGAACATTGCTCGATGCTCCCATCTGGTGGCGGCCT
1041 CAGGAACCCACGGGAACCTGGAAGGAGGCTCTTTGTGAGACCTGGGCAAAGGATGGGGCAGCTCGTCGATGATTTTTTTG
1121 TGTTTCCAGGCTTCCTGTGTGATCCTGGCCCTCCGGCCGCTAGAGAGAGGATTGGGAAACCCCACTGTCAGCTCTGCATC
1201 TGCCCCCACTACCCTCCTCTGCCCTATTCTGTCCCTGCCCCTCCAAGCTGAAGAAGGTCCTTGTGGGGCGTCCTCATTTC
1281 TTCCTCAAATATAAGGAGGAAGATACCAATTAAAAGCTCATAGTATCAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' ggGUGGUCGA--CGAGGGACCGGGu 5'
            | ||  ||   ||| ||||||| 
Target 5' ttCTCCTCCTCCCCTCACTGGCCCc 3'
 271 - 295 155.00 -22.10
2 
miRNA  3' ggguGGUCG-ACGAGGGACCGGGu 5'
              || |: || | |||||||| 
Target 5' gcttCCTGTGTGAT-CCTGGCCCt 3'
 1130 - 1152 154.00 -22.80
3 
miRNA  3' ggGUGGUCGACGAGGGACCGGGu 5'
            | |:: |  ||||||||||: 
Target 5' ctCCCTGCCCCCTCCCTGGCCTt 3'
 13 - 35 149.00 -28.40
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30447996 13 COSMIC
COSN30451488 14 COSMIC
COSN30452801 18 COSMIC
COSN27005055 21 COSMIC
COSN30467463 22 COSMIC
COSN30461732 23 COSMIC
COSN30488492 24 COSMIC
COSN31503018 27 COSMIC
COSN30682465 33 COSMIC
COSN30454537 40 COSMIC
COSN30180369 64 COSMIC
COSN8838328 206 COSMIC
COSN31779196 274 COSMIC
COSN9670232 579 COSMIC
COSN31615102 713 COSMIC
COSN8838329 731 COSMIC
COSN24626326 846 COSMIC
COSN1721283 1030 COSMIC
COSN29326911 1121 COSMIC
rs3803884 660 GWAS
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1415293508 3 dbSNP
rs574547550 4 dbSNP
rs752001456 6 dbSNP
rs755679037 7 dbSNP
rs750734174 9 dbSNP
rs755191437 9 dbSNP
rs1426640046 10 dbSNP
rs763588935 10 dbSNP
rs1158465533 11 dbSNP
rs1369061843 12 dbSNP
rs1311135080 14 dbSNP
rs543077337 15 dbSNP
rs1324408443 16 dbSNP
rs1446473240 17 dbSNP
rs1233451903 18 dbSNP
rs879872295 19 dbSNP
rs1183153814 20 dbSNP
rs767365030 20 dbSNP
rs756910064 21 dbSNP
rs778391622 22 dbSNP
rs1375053168 23 dbSNP
rs745682201 25 dbSNP
rs1274518788 26 dbSNP
rs758071644 27 dbSNP
rs1271871996 30 dbSNP
rs1321738485 31 dbSNP
rs1200948193 32 dbSNP
rs780098060 33 dbSNP
rs1291155166 34 dbSNP
rs1271154707 35 dbSNP
rs1333948250 37 dbSNP
rs1230539518 38 dbSNP
rs373946636 40 dbSNP
rs768901096 42 dbSNP
rs776833396 43 dbSNP
rs576492266 48 dbSNP
rs1451443245 49 dbSNP
rs1176772404 51 dbSNP
rs1377245135 53 dbSNP
rs1415252435 56 dbSNP
rs1461508507 64 dbSNP
rs1460243666 71 dbSNP
rs1165328482 73 dbSNP
rs1163661531 76 dbSNP
rs545449963 77 dbSNP
rs1436885999 89 dbSNP
rs1023556722 95 dbSNP
rs1440515483 100 dbSNP
rs1252874082 109 dbSNP
rs181069107 120 dbSNP
rs748193535 121 dbSNP
rs949467005 123 dbSNP
rs1357998568 126 dbSNP
rs772699832 128 dbSNP
rs923575915 140 dbSNP
rs1353838242 141 dbSNP
rs935083748 147 dbSNP
rs528031057 150 dbSNP
rs1271400823 151 dbSNP
rs989615165 159 dbSNP
rs914772904 165 dbSNP
rs1406687845 174 dbSNP
rs1046477464 179 dbSNP
rs1363676857 183 dbSNP
rs773892907 184 dbSNP
rs1331440024 185 dbSNP
rs947532915 186 dbSNP
rs547784975 187 dbSNP
rs1420328398 190 dbSNP
rs1365616407 198 dbSNP
rs1050048326 204 dbSNP
rs1231210114 206 dbSNP
rs752626706 215 dbSNP
rs1426295504 218 dbSNP
rs753254747 219 dbSNP
rs1489993998 232 dbSNP
rs944259591 234 dbSNP
rs1218016638 248 dbSNP
rs935323309 249 dbSNP
rs1236430072 253 dbSNP
rs1316032274 254 dbSNP
rs1283664731 256 dbSNP
rs1018218907 259 dbSNP
rs1225073097 267 dbSNP
rs1343430780 268 dbSNP
rs1053083796 269 dbSNP
rs994293234 273 dbSNP
rs1239122351 277 dbSNP
rs893025863 279 dbSNP
rs1027477588 280 dbSNP
rs1186569800 284 dbSNP
rs1415060040 285 dbSNP
rs758893761 300 dbSNP
rs1049560614 302 dbSNP
rs1012497886 303 dbSNP
rs1023440835 306 dbSNP
rs889590699 309 dbSNP
rs1429045207 311 dbSNP
rs1399317113 312 dbSNP
rs747351878 315 dbSNP
rs1019747539 319 dbSNP
rs561486614 320 dbSNP
rs530254290 321 dbSNP
rs1485274706 322 dbSNP
rs184370068 323 dbSNP
rs1027260484 324 dbSNP
rs1282470280 326 dbSNP
rs569440449 328 dbSNP
rs538242936 337 dbSNP
rs952954549 338 dbSNP
rs1239951691 341 dbSNP
rs764043569 342 dbSNP
rs551794817 346 dbSNP
rs575607903 350 dbSNP
rs1403031874 354 dbSNP
rs1338881412 355 dbSNP
rs1468437266 359 dbSNP
rs751962931 361 dbSNP
rs953115851 362 dbSNP
rs1280525422 363 dbSNP
rs139795910 366 dbSNP
rs1335317169 369 dbSNP
rs866700097 370 dbSNP
rs970852257 377 dbSNP
rs1187159816 379 dbSNP
rs1427344950 381 dbSNP
rs1254694364 387 dbSNP
rs1185042521 388 dbSNP
rs58588562 398 dbSNP
rs1262253338 399 dbSNP
rs1181984656 406 dbSNP
rs879364696 408 dbSNP
rs935371479 409 dbSNP
rs1468324929 410 dbSNP
rs1383534358 417 dbSNP
rs1174644654 432 dbSNP
rs554586258 433 dbSNP
rs915214577 442 dbSNP
rs764808759 446 dbSNP
rs1434583193 448 dbSNP
rs1394795669 451 dbSNP
rs1311598785 453 dbSNP
rs918621860 459 dbSNP
rs1385295692 462 dbSNP
rs1373020421 464 dbSNP
rs1182108704 471 dbSNP
rs368096666 471 dbSNP
rs1048352898 472 dbSNP
rs1306450954 474 dbSNP
rs1195154120 476 dbSNP
rs888538708 479 dbSNP
rs1049589939 481 dbSNP
rs1243929176 487 dbSNP
rs1334178754 489 dbSNP
rs889621853 490 dbSNP
rs1235742799 491 dbSNP
rs1444659858 495 dbSNP
rs149669461 495 dbSNP
rs1044940491 496 dbSNP
rs775052860 503 dbSNP
rs57730294 504 dbSNP
rs993904658 506 dbSNP
rs76604087 512 dbSNP
rs1384079399 521 dbSNP
rs1249255306 525 dbSNP
rs763987635 527 dbSNP
rs374735432 528 dbSNP
rs1180870650 537 dbSNP
rs1490485747 541 dbSNP
rs1395999669 545 dbSNP
rs1454105383 546 dbSNP
rs1012512205 548 dbSNP
rs1023887491 555 dbSNP
rs576657991 578 dbSNP
rs543273518 579 dbSNP
rs1392547195 581 dbSNP
rs565240058 584 dbSNP
rs982671308 585 dbSNP
rs1031115396 593 dbSNP
rs572354039 594 dbSNP
rs1462982841 595 dbSNP
rs866468110 599 dbSNP
rs761765453 600 dbSNP
rs1224454161 605 dbSNP
rs915242960 613 dbSNP
rs985820120 615 dbSNP
rs1404892392 616 dbSNP
rs189304344 618 dbSNP
rs985376928 621 dbSNP
rs977011956 622 dbSNP
rs561439758 625 dbSNP
rs767263624 633 dbSNP
rs530292339 638 dbSNP
rs1309151185 654 dbSNP
rs3803884 660 dbSNP
rs181976637 669 dbSNP
rs896964047 670 dbSNP
rs1479374820 676 dbSNP
rs1242746049 687 dbSNP
rs1218101559 708 dbSNP
rs1445374396 714 dbSNP
rs1283779494 716 dbSNP
rs563033212 719 dbSNP
rs1253226353 722 dbSNP
rs753652464 729 dbSNP
rs35628284 748 dbSNP
rs1048110209 753 dbSNP
rs532036952 756 dbSNP
rs1192112474 760 dbSNP
rs1011918515 767 dbSNP
rs1045157957 770 dbSNP
rs1363317080 773 dbSNP
rs906397020 777 dbSNP
rs1250329572 779 dbSNP
rs1324199866 780 dbSNP
rs1003373233 788 dbSNP
rs551857729 790 dbSNP
rs1023918592 791 dbSNP
rs892384471 801 dbSNP
rs1170371483 808 dbSNP
rs1413819991 809 dbSNP
rs558476699 810 dbSNP
rs1188242074 812 dbSNP
rs1474429341 814 dbSNP
rs1247505994 826 dbSNP
rs1022396814 830 dbSNP
rs1462875038 832 dbSNP
rs888768686 834 dbSNP
rs1003771460 840 dbSNP
rs1031603613 843 dbSNP
rs1308466695 849 dbSNP
rs1007298317 855 dbSNP
rs956854095 864 dbSNP
rs145488779 866 dbSNP
rs1022327256 872 dbSNP
rs1296325761 874 dbSNP
rs953417954 875 dbSNP
rs376853668 880 dbSNP
rs1384609855 884 dbSNP
rs965730643 885 dbSNP
rs752786421 887 dbSNP
rs534334002 891 dbSNP
rs768319242 902 dbSNP
rs1172375001 903 dbSNP
rs778539741 908 dbSNP
rs1363840801 910 dbSNP
rs965687109 913 dbSNP
rs976659204 920 dbSNP
rs918424904 925 dbSNP
rs758597857 930 dbSNP
rs1382647684 932 dbSNP
rs1446644549 934 dbSNP
rs1241465867 935 dbSNP
rs1181524492 938 dbSNP
rs1481123176 949 dbSNP
rs1235024487 950 dbSNP
rs1307467554 956 dbSNP
rs929819343 956 dbSNP
rs148428646 958 dbSNP
rs909616857 960 dbSNP
rs540865577 961 dbSNP
rs1044767110 968 dbSNP
rs1227398804 969 dbSNP
rs537242541 972 dbSNP
rs1333657934 973 dbSNP
rs1439893092 978 dbSNP
rs1369924286 981 dbSNP
rs1211469568 990 dbSNP
rs115652159 1000 dbSNP
rs1426580556 1003 dbSNP
rs562245895 1010 dbSNP
rs781561422 1011 dbSNP
rs577123300 1014 dbSNP
rs1004204272 1017 dbSNP
rs1186365214 1018 dbSNP
rs946648329 1022 dbSNP
rs1043642367 1036 dbSNP
rs1270182523 1037 dbSNP
rs1260241536 1038 dbSNP
rs1052664371 1052 dbSNP
rs1490680755 1053 dbSNP
rs1263229633 1059 dbSNP
rs1317185449 1062 dbSNP
rs746275971 1075 dbSNP
rs888819536 1077 dbSNP
rs1007183820 1078 dbSNP
rs1018532691 1082 dbSNP
rs901615924 1084 dbSNP
rs1363789787 1087 dbSNP
rs1293061730 1092 dbSNP
rs1454485031 1093 dbSNP
rs892659966 1098 dbSNP
rs1460027166 1102 dbSNP
rs372034372 1105 dbSNP
rs78920086 1106 dbSNP
rs953449053 1108 dbSNP
rs1202210949 1109 dbSNP
rs1479780748 1109 dbSNP
rs1264616430 1111 dbSNP
rs1454110900 1113 dbSNP
rs1485920808 1119 dbSNP
rs1288122513 1122 dbSNP
rs1359746520 1131 dbSNP
rs1262080309 1137 dbSNP
rs142585460 1152 dbSNP
rs1018904909 1155 dbSNP
rs966038946 1156 dbSNP
rs977109056 1159 dbSNP
rs772129442 1160 dbSNP
rs951316700 1167 dbSNP
rs1382810646 1168 dbSNP
rs1317200924 1169 dbSNP
rs1215486811 1177 dbSNP
rs1287275352 1177 dbSNP
rs939434529 1177 dbSNP
rs1407294150 1180 dbSNP
rs1259376993 1182 dbSNP
rs988224579 1182 dbSNP
rs529482755 1186 dbSNP
rs946568731 1187 dbSNP
rs1194553672 1188 dbSNP
rs1212253327 1194 dbSNP
rs1043911683 1199 dbSNP
rs532350387 1200 dbSNP
rs541095057 1205 dbSNP
rs947806230 1208 dbSNP
rs111978478 1215 dbSNP
rs993679888 1217 dbSNP
rs1255271359 1220 dbSNP
rs1228085199 1222 dbSNP
rs1309320503 1227 dbSNP
rs927626731 1232 dbSNP
rs939020068 1242 dbSNP
rs1418764293 1244 dbSNP
rs1295581706 1249 dbSNP
rs1053153826 1253 dbSNP
rs575069601 1256 dbSNP
rs1343241395 1257 dbSNP
rs543714719 1261 dbSNP
rs563491086 1262 dbSNP
rs887315724 1263 dbSNP
rs1043884961 1270 dbSNP
rs375202513 1271 dbSNP
rs1374285073 1281 dbSNP
rs1280830249 1294 dbSNP
rs1017487641 1307 dbSNP
rs1007607873 1310 dbSNP
rs1222881051 1320 dbSNP
rs1185059728 1322 dbSNP
rs1018978226 1332 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions TZM-bl
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM1462574. RNA binding protein: AGO2. Condition:TZM-bl ami BaL ...

- Whisnant AW; Bogerd HP; Flores O; Ho P; et al., 2013, mBio.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' ggGUGGUCGA--CGAGGGACcgggu 5'
            | ||  ||   ||| |||     
Target 5' uuCUCCUCCUCCCCUCACUG----- 3'
 		2 - 21
Article - Whisnant AW; Bogerd HP; Flores O; Ho P; et al.
- mBio, 2013
UNLABELLED: The question of how HIV-1 interfaces with cellular microRNA (miRNA) biogenesis and effector mechanisms has been highly controversial. Here, we first used deep sequencing of small RNAs present in two different infected cell lines (TZM-bl and C8166) and two types of primary human cells (CD4(+) peripheral blood mononuclear cells [PBMCs] and macrophages) to unequivocally demonstrate that HIV-1 does not encode any viral miRNAs. Perhaps surprisingly, we also observed that infection of T cells by HIV-1 has only a modest effect on the expression of cellular miRNAs at early times after infection. Comprehensive analysis of miRNA binding to the HIV-1 genome using the photoactivatable ribonucleoside-induced cross-linking and immunoprecipitation (PAR-CLIP) technique revealed several binding sites for cellular miRNAs, a subset of which were shown to be capable of mediating miRNA-mediated repression of gene expression. However, the main finding from this analysis is that HIV-1 transcripts are largely refractory to miRNA binding, most probably due to extensive viral RNA secondary structure. Together, these data demonstrate that HIV-1 neither encodes viral miRNAs nor strongly influences cellular miRNA expression, at least early after infection, and imply that HIV-1 transcripts have evolved to avoid inhibition by preexisting cellular miRNAs by adopting extensive RNA secondary structures that occlude most potential miRNA binding sites. IMPORTANCE: MicroRNAs (miRNAs) are a ubiquitous class of small regulatory RNAs that serve as posttranscriptional regulators of gene expression. Previous work has suggested that HIV-1 might subvert the function of the cellular miRNA machinery by expressing viral miRNAs or by dramatically altering the level of cellular miRNA expression. Using very sensitive approaches, we now demonstrate that neither of these ideas is in fact correct. Moreover, HIV-1 transcripts appear to largely avoid regulation by cellular miRNAs by adopting an extensive RNA secondary structure that occludes the ability of cellular miRNAs to interact with viral mRNAs. Together, these data suggest that HIV-1, rather than seeking to control miRNA function in infected cells, has instead evolved a mechanism to become largely invisible to cellular miRNA effector mechanisms.
LinkOut: [PMID: 23592263]
CLIP-seq Support 1 for dataset GSM1462574
Method / RBP PAR-CLIP / AGO2
Cell line / Condition TZM-bl / TZM-bl ami BaL
Location of target site ENST00000311378.4 | 3UTR | AUUCUCCUCCUCCCCUCACUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23592263 / GSE59944
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
87 hsa-miR-4640-5p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT100106 ABT1 activator of basal transcription 1 2 8
MIRT248144 LMBR1L limb development membrane protein 1 like 2 2
MIRT327062 KLHL15 kelch like family member 15 2 2
MIRT347231 GATAD2A GATA zinc finger domain containing 2A 2 2
MIRT450221 CENPN centromere protein N 2 2
MIRT451264 NDUFA11 NADH:ubiquinone oxidoreductase subunit A11 2 2
MIRT452701 C1orf226 chromosome 1 open reading frame 226 2 2
MIRT453212 CERS1 ceramide synthase 1 2 2
MIRT454822 POLR2J3 RNA polymerase II subunit J3 2 2
MIRT454883 RAD50 RAD50 double strand break repair protein 2 2
MIRT455783 TAF8 TATA-box binding protein associated factor 8 2 2
MIRT455858 TMEM254 transmembrane protein 254 2 2
MIRT457615 UPK3BL uroplakin 3B like 1 2 2
MIRT457822 ITPRIP inositol 1,4,5-trisphosphate receptor interacting protein 2 4
MIRT458344 NOC2L NOC2 like nucleolar associated transcriptional repressor 2 2
MIRT458376 ITM2C integral membrane protein 2C 2 2
MIRT458928 SAMD4B sterile alpha motif domain containing 4B 2 2
MIRT459066 WFIKKN2 WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2 2 2
MIRT460138 ASB16 ankyrin repeat and SOCS box containing 16 2 2
MIRT460818 FSTL4 follistatin like 4 2 2
MIRT461285 COX10 COX10, heme A:farnesyltransferase cytochrome c oxidase assembly factor 2 2
MIRT462738 EFNB1 ephrin B1 2 2
MIRT464556 UBTF upstream binding transcription factor, RNA polymerase I 2 2
MIRT477910 DUSP2 dual specificity phosphatase 2 2 2
MIRT479073 CNNM4 cyclin and CBS domain divalent metal cation transport mediator 4 2 4
MIRT479534 CDC5L cell division cycle 5 like 2 4
MIRT485628 EEPD1 endonuclease/exonuclease/phosphatase family domain containing 1 2 2
MIRT489896 PPIC peptidylprolyl isomerase C 2 4
MIRT490737 SRCIN1 SRC kinase signaling inhibitor 1 2 2
MIRT491201 MLLT1 MLLT1, super elongation complex subunit 2 4
MIRT492681 PHYHIP phytanoyl-CoA 2-hydroxylase interacting protein 2 2
MIRT494593 ATG7 autophagy related 7 2 2
MIRT495061 PADI3 peptidyl arginine deiminase 3 2 4
MIRT496623 TMEM67 transmembrane protein 67 2 2
MIRT497177 ZBTB40 zinc finger and BTB domain containing 40 2 2
MIRT498217 TLN2 talin 2 2 2
MIRT498306 BCL11B B-cell CLL/lymphoma 11B 2 2
MIRT499668 NPHP3 nephrocystin 3 2 2
MIRT508080 ANKRD52 ankyrin repeat domain 52 2 2
MIRT509707 ANKRD23 ankyrin repeat domain 23 2 2
MIRT509841 FOS Fos proto-oncogene, AP-1 transcription factor subunit 2 2
MIRT512814 ARRDC2 arrestin domain containing 2 2 2
MIRT513353 SLIT1 slit guidance ligand 1 2 2
MIRT514293 FXYD5 FXYD domain containing ion transport regulator 5 2 2
MIRT516598 FAM89A family with sequence similarity 89 member A 2 4
MIRT516616 DARS2 aspartyl-tRNA synthetase 2, mitochondrial 2 2
MIRT518348 CCL5 C-C motif chemokine ligand 5 2 2
MIRT520130 WSB1 WD repeat and SOCS box containing 1 2 2
MIRT522072 ORAI2 ORAI calcium release-activated calcium modulator 2 2 2
MIRT526461 OSBPL5 oxysterol binding protein like 5 2 2
MIRT528278 MBL2 mannose binding lectin 2 2 2
MIRT534844 RAB15 RAB15, member RAS oncogene family 2 4
MIRT542245 HSPA4L heat shock protein family A (Hsp70) member 4 like 2 2
MIRT543299 ZNF585B zinc finger protein 585B 2 2
MIRT552456 ZNF410 zinc finger protein 410 2 2
MIRT553641 TJAP1 tight junction associated protein 1 2 2
MIRT557103 HOXA3 homeobox A3 2 2
MIRT570782 FANCA Fanconi anemia complementation group A 2 2
MIRT630912 ZMAT2 zinc finger matrin-type 2 2 2
MIRT631034 ZNF878 zinc finger protein 878 2 2
MIRT639017 AAK1 AP2 associated kinase 1 2 2
MIRT648596 ZYG11B zyg-11 family member B, cell cycle regulator 2 2
MIRT648939 ATP5A1 ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle 2 2
MIRT652834 TACO1 translational activator of cytochrome c oxidase I 2 2
MIRT659347 CSRP1 cysteine and glycine rich protein 1 2 2
MIRT664163 APOBEC3F apolipoprotein B mRNA editing enzyme catalytic subunit 3F 2 2
MIRT670511 ZSCAN22 zinc finger and SCAN domain containing 22 2 2
MIRT671246 TMEM41B transmembrane protein 41B 2 2
MIRT672120 ATP6V0A2 ATPase H+ transporting V0 subunit a2 2 2
MIRT672313 CD3D CD3d molecule 2 2
MIRT672543 BRMS1L breast cancer metastasis-suppressor 1 like 2 2
MIRT673036 SGPL1 sphingosine-1-phosphate lyase 1 2 2
MIRT673814 DARS aspartyl-tRNA synthetase 2 2
MIRT674858 GINM1 glycoprotein integral membrane 1 2 2
MIRT674970 SH3BP2 SH3 domain binding protein 2 2 2
MIRT675185 KIF1C kinesin family member 1C 2 2
MIRT675219 UGDH UDP-glucose 6-dehydrogenase 2 2
MIRT675558 MED16 mediator complex subunit 16 2 2
MIRT682566 EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1 2 2
MIRT684640 PDE4C phosphodiesterase 4C 2 2
MIRT689722 ATXN2 ataxin 2 2 2
MIRT693594 SLC39A1 solute carrier family 39 member 1 2 2
MIRT704745 CDKN2B cyclin dependent kinase inhibitor 2B 2 2
MIRT712779 ZNF154 zinc finger protein 154 2 2
MIRT718118 OTOF otoferlin 2 2
MIRT720115 SAMD4A sterile alpha motif domain containing 4A 2 2
MIRT720275 EIF1AD eukaryotic translation initiation factor 1A domain containing 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-4640 Gemcitabine 60750 NSC613327 approved resistant High Pancreatic Cancer cell line (PANC-1)
hsa-mir-4640 Fluorouracil 3385 NSC19893 approved resistant High Pancreatic Cancer cell line (PANC-1)
hsa-mir-4640 Cisplatin 5460033 NSC119875 approved resistant cell line (BxPC3)
hsa-miR-4640-5p Platinum 23939 sensitive High Ovarian Cancer tissue
hsa-miR-4640-5p Paclitaxel 36314 NSC125973 approved resistant High Non-Small Cell Lung Cancer cell line (A549)
hsa-miR-4640-5p Gemcitabine 60750 NSC613327 approved resistant High Pancreatic Cancer cell line (AsPC-1)
hsa-miR-4640-5p Gefitinib 123631 NSC715055 approved resistant cell line (PC9)
hsa-miR-4640-5p Osimertinib 71496458 NSC779217 approved resistant cell line (HCC827)
hsa-miR-4640-5p Osimertinib 71496458 NSC779217 approved resistant cell line (PC9)
hsa-miR-4640-5p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-4640-5p Gefitinib 123631 NSC715055 approved resistant cell line (HCC827)
hsa-miR-4640-5p Osimertinib 71496458 NSC779217 approved sensitive cell line (H1975)
hsa-miR-4640-5p Paclitaxel 36314 NSC125973 approved resistant cell line (A2780)
hsa-miR-4640-5p Docetaxel+Cisplatin+5-Fluorouracil resistant tissue (hypopharyngeal squamous cell carcinoma)

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