miRTarBase - #MIRT459621


—
pre-miRNA Information
pre-miRNA hsa-mir-655   
Genomic Coordinates chr14: 101049550 - 101049646
Synonyms MIRN655, hsa-mir-655, MIR655
Description Homo sapiens miR-655 stem-loop
Comment None
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-655-5p
Sequence 23| AGAGGUUAUCCGUGUUAUGUUC |44
Evidence Experimental
Experiments Illumina
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs766575622 4 dbSNP
rs754023562 5 dbSNP
rs757713353 10 dbSNP
rs369862924 11 dbSNP
rs552601004 12 dbSNP
rs753191773 14 dbSNP
rs569206109 15 dbSNP
rs373094888 18 dbSNP
rs778280798 22 dbSNP
Putative Targets

Gene Information
Gene Symbol SLC25A33   
Synonyms BMSC-MCP, PNC1
Description solute carrier family 25 member 33
Transcript NM_032315   
Expression
Putative miRNA Targets on SLC25A33
3'UTR of SLC25A33
(miRNA target sites are highlighted)		 
>SLC25A33|NM_032315|3'UTR
   1 CAGGCCGGAAAATTGTGCTCTAGAAGAATAAAACTGAAAAACTCTAGAGAATTTTTTTTCCCCATTGATGTTTAGAAAGT
  81 TTGAGACTGAAACAGGAAAGGCCATAAAATATCTGGTTCATATCACCTGTTGGACATTTCCTTTTGGATTCATGCTTTCT
 161 GGAAGGTTTAAATTCATTAACGTTAATAGTTAATTATAACTTTTTTTTTAACTTAAGAGGATTCAGGGTTAAGCACCAAC
 241 TAAATTAAATCATGCTATTTAATTTAAGTATAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' cuugUAUU-GUGCCUAUUGGAGa 5'
              |||: :|   |||||:|: 
Target 5' gttaATAGTTAATTATAACTTTt 3'
 182 - 204 118.00 -5.10
2 
miRNA  3' cuugUAUUGUGCCUAUUGGAGa 5'
              |||| || || || ||| 
Target 5' aagaATAAAACTGAAAAACTCt 3'
 24 - 45 110.00 -7.20
3 
miRNA  3' cuUGUAUUGU--GCC-----UAUUGGAga 5'
            |:| ||:|  :||     || ||||  
Target 5' ccATAAAATATCTGGTTCATATCACCTgt 3'
 102 - 130 102.00 -5.10
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30129860 5 COSMIC
COSN30111480 8 COSMIC
COSN32073873 11 COSMIC
COSN31568547 27 COSMIC
COSN20061585 43 COSMIC
COSN30138919 60 COSMIC
COSN30707741 60 COSMIC
COSN8522679 182 COSMIC
COSN31539435 210 COSMIC
COSN8522685 902 COSMIC
COSN25342550 1073 COSMIC
COSN27305576 1233 COSMIC
COSN22618119 1234 COSMIC
COSN21005638 1872 COSMIC
COSN15972316 2383 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs200121512 2 dbSNP
rs188152435 5 dbSNP
rs369098929 7 dbSNP
rs192868792 8 dbSNP
rs201071322 12 dbSNP
rs1243612368 16 dbSNP
rs745927630 19 dbSNP
rs770268183 20 dbSNP
rs776009973 21 dbSNP
rs531828794 25 dbSNP
rs1383111964 27 dbSNP
rs1449726552 28 dbSNP
rs764517895 36 dbSNP
rs1001304129 42 dbSNP
rs902495206 42 dbSNP
rs774172406 44 dbSNP
rs1331769203 45 dbSNP
rs370888086 45 dbSNP
rs765868970 45 dbSNP
rs761607777 46 dbSNP
rs1430679717 50 dbSNP
rs753204032 52 dbSNP
rs755849174 55 dbSNP
rs1187216954 64 dbSNP
rs1010539005 81 dbSNP
rs1191680709 90 dbSNP
rs1372703115 97 dbSNP
rs1050954450 121 dbSNP
rs1231313946 123 dbSNP
rs890913795 126 dbSNP
rs775135671 129 dbSNP
rs15349 142 dbSNP
rs1006680218 147 dbSNP
rs1475890375 148 dbSNP
rs1018430526 149 dbSNP
rs1028118725 150 dbSNP
rs1414117526 153 dbSNP
rs1479392564 154 dbSNP
rs1175490968 163 dbSNP
rs1402618616 181 dbSNP
rs955416683 182 dbSNP
rs549961922 194 dbSNP
rs1353495018 201 dbSNP
rs568761488 201 dbSNP
rs1015782152 210 dbSNP
rs1352903032 215 dbSNP
rs539477831 215 dbSNP
rs1222193163 221 dbSNP
rs1283104868 222 dbSNP
rs962379656 223 dbSNP
rs995114462 225 dbSNP
rs1271159881 228 dbSNP
rs973746332 229 dbSNP
rs1415541019 234 dbSNP
rs1254030862 237 dbSNP
rs1025238456 240 dbSNP
rs1489853109 250 dbSNP
rs1198584952 257 dbSNP
rs920151420 262 dbSNP
rs959613208 276 dbSNP
rs1406245275 281 dbSNP
rs773016954 282 dbSNP
rs1315681950 293 dbSNP
rs1429952244 294 dbSNP
rs1325465456 298 dbSNP
rs950982959 299 dbSNP
rs984077621 305 dbSNP
rs1227760394 315 dbSNP
rs1363148726 316 dbSNP
rs917428506 323 dbSNP
rs1323477268 325 dbSNP
rs1332121743 328 dbSNP
rs918089078 337 dbSNP
rs760321337 338 dbSNP
rs1272251250 353 dbSNP
rs949608738 356 dbSNP
rs148118322 357 dbSNP
rs924036456 368 dbSNP
rs532851175 370 dbSNP
rs1357365057 379 dbSNP
rs113180783 387 dbSNP
rs1053720475 394 dbSNP
rs1453209145 400 dbSNP
rs565693377 405 dbSNP
rs1054479894 406 dbSNP
rs1190802083 411 dbSNP
rs1241276842 412 dbSNP
rs571053796 415 dbSNP
rs1382931354 421 dbSNP
rs1203439960 422 dbSNP
rs1423464353 423 dbSNP
rs1163279463 435 dbSNP
rs12076727 436 dbSNP
rs1051447753 437 dbSNP
rs569763790 440 dbSNP
rs890992690 441 dbSNP
rs1007122542 448 dbSNP
rs1008506136 449 dbSNP
rs1300101630 456 dbSNP
rs1380786203 457 dbSNP
rs183743316 462 dbSNP
rs558794309 463 dbSNP
rs1358437257 466 dbSNP
rs376993070 467 dbSNP
rs961437438 476 dbSNP
rs995131547 477 dbSNP
rs1385775356 479 dbSNP
rs1025273488 481 dbSNP
rs1026644295 483 dbSNP
rs576925930 490 dbSNP
rs1459950362 491 dbSNP
rs766237313 495 dbSNP
rs1388463322 503 dbSNP
rs534936559 506 dbSNP
rs918194253 507 dbSNP
rs970893480 508 dbSNP
rs1024970703 511 dbSNP
rs971621121 535 dbSNP
rs980661329 541 dbSNP
rs978685567 542 dbSNP
rs927423560 545 dbSNP
rs957456687 546 dbSNP
rs990192577 550 dbSNP
rs913273295 554 dbSNP
rs552968460 563 dbSNP
rs572436003 569 dbSNP
rs1200663842 570 dbSNP
rs1257740218 573 dbSNP
rs1051050028 577 dbSNP
rs542604822 581 dbSNP
rs764896517 582 dbSNP
rs1039524576 584 dbSNP
rs150616294 586 dbSNP
rs1261496824 587 dbSNP
rs931067836 588 dbSNP
rs1404338370 590 dbSNP
rs1046797025 600 dbSNP
rs1404539157 642 dbSNP
rs1049651499 643 dbSNP
rs1307452084 644 dbSNP
rs1243572073 645 dbSNP
rs576134908 656 dbSNP
rs1281206804 661 dbSNP
rs1425446325 662 dbSNP
rs762807420 664 dbSNP
rs543473118 667 dbSNP
rs1233617360 674 dbSNP
rs866181104 679 dbSNP
rs886812310 684 dbSNP
rs1013659803 686 dbSNP
rs1479426941 687 dbSNP
rs1194767349 690 dbSNP
rs1008037354 696 dbSNP
rs374398029 697 dbSNP
rs896868329 699 dbSNP
rs565490664 706 dbSNP
rs1371228891 717 dbSNP
rs1427724621 717 dbSNP
rs569184884 717 dbSNP
rs995252904 717 dbSNP
rs77009538 719 dbSNP
rs1453847211 730 dbSNP
rs1159851811 731 dbSNP
rs1026759054 732 dbSNP
rs894800556 742 dbSNP
rs1366751079 746 dbSNP
rs1011934553 753 dbSNP
rs1305449509 754 dbSNP
rs139722952 774 dbSNP
rs1274811927 776 dbSNP
rs1343679754 781 dbSNP
rs1337752290 794 dbSNP
rs548099951 798 dbSNP
rs752758201 805 dbSNP
rs971391178 809 dbSNP
rs1192175231 816 dbSNP
rs1034517876 818 dbSNP
rs957521182 827 dbSNP
rs990264881 830 dbSNP
rs1168191750 831 dbSNP
rs1460153620 843 dbSNP
rs1390947894 849 dbSNP
rs1431719277 854 dbSNP
rs559781943 856 dbSNP
rs989503180 859 dbSNP
rs188009345 860 dbSNP
rs922047281 864 dbSNP
rs1306924330 869 dbSNP
rs548209548 872 dbSNP
rs931954227 876 dbSNP
rs1433996485 877 dbSNP
rs756233552 886 dbSNP
rs1297889936 887 dbSNP
rs1243175285 891 dbSNP
rs569630364 891 dbSNP
rs987223868 897 dbSNP
rs912441720 905 dbSNP
rs115189747 907 dbSNP
rs1323052452 916 dbSNP
rs942619401 917 dbSNP
rs1248906167 930 dbSNP
rs371636476 935 dbSNP
rs552271053 947 dbSNP
rs975262376 948 dbSNP
rs1263477236 952 dbSNP
rs1484113736 971 dbSNP
rs570651069 976 dbSNP
rs778024056 980 dbSNP
rs534501742 981 dbSNP
rs919799658 984 dbSNP
rs931141243 987 dbSNP
rs1046827233 988 dbSNP
rs753965907 989 dbSNP
rs1166831156 999 dbSNP
rs1343297098 1012 dbSNP
rs886842599 1015 dbSNP
rs116046263 1016 dbSNP
rs1390430819 1024 dbSNP
rs1183670252 1026 dbSNP
rs1449982533 1034 dbSNP
rs1426627343 1035 dbSNP
rs1046502577 1046 dbSNP
rs904824460 1049 dbSNP
rs1222631370 1065 dbSNP
rs1001824959 1069 dbSNP
rs1336373841 1072 dbSNP
rs1213895921 1074 dbSNP
rs1272185163 1077 dbSNP
rs757522199 1080 dbSNP
rs767019220 1084 dbSNP
rs1361198453 1091 dbSNP
rs1233315578 1094 dbSNP
rs1469556025 1100 dbSNP
rs1175464839 1108 dbSNP
rs1460786101 1109 dbSNP
rs1475596857 1113 dbSNP
rs1164423074 1114 dbSNP
rs1410829336 1117 dbSNP
rs893335387 1121 dbSNP
rs1467451565 1132 dbSNP
rs1397814922 1133 dbSNP
rs1329962547 1136 dbSNP
rs192512471 1138 dbSNP
rs1020427009 1139 dbSNP
rs1356769176 1150 dbSNP
rs1233389351 1157 dbSNP
rs568251306 1158 dbSNP
rs1332221579 1160 dbSNP
rs958185853 1160 dbSNP
rs149428661 1166 dbSNP
rs1273424611 1171 dbSNP
rs1029009027 1174 dbSNP
rs951539144 1180 dbSNP
rs367760788 1199 dbSNP
rs911873640 1207 dbSNP
rs1187319487 1213 dbSNP
rs113218549 1219 dbSNP
rs1408604066 1219 dbSNP
rs200517369 1219 dbSNP
rs536633738 1219 dbSNP
rs931112478 1225 dbSNP
rs543531771 1229 dbSNP
rs986868460 1234 dbSNP
rs894865720 1239 dbSNP
rs1353082977 1240 dbSNP
rs996265508 1245 dbSNP
rs558762039 1246 dbSNP
rs71580100 1247 dbSNP
rs1270446251 1248 dbSNP
rs577401971 1249 dbSNP
rs1235628669 1250 dbSNP
rs1338455320 1251 dbSNP
rs1250588877 1252 dbSNP
rs1020037692 1256 dbSNP
rs964011568 1257 dbSNP
rs1348503011 1263 dbSNP
rs1028826614 1264 dbSNP
rs1255464117 1266 dbSNP
rs1448854984 1268 dbSNP
rs555873744 1270 dbSNP
rs1241767123 1271 dbSNP
rs952573228 1274 dbSNP
rs954735941 1275 dbSNP
rs987387951 1286 dbSNP
rs11121446 1288 dbSNP
rs748521127 1289 dbSNP
rs1172364883 1292 dbSNP
rs1031313806 1296 dbSNP
rs189289155 1302 dbSNP
rs574210841 1308 dbSNP
rs1318510989 1309 dbSNP
rs926314550 1319 dbSNP
rs906171050 1320 dbSNP
rs937646247 1324 dbSNP
rs1426423028 1325 dbSNP
rs60049263 1327 dbSNP
rs1052606966 1328 dbSNP
rs1352867744 1328 dbSNP
rs999227762 1328 dbSNP
rs1056079408 1338 dbSNP
rs894078318 1338 dbSNP
rs893410661 1343 dbSNP
rs1011807078 1345 dbSNP
rs1301852027 1346 dbSNP
rs1253994506 1352 dbSNP
rs1454135609 1353 dbSNP
rs1042285536 1355 dbSNP
rs780757529 1356 dbSNP
rs746489377 1357 dbSNP
rs1008769374 1363 dbSNP
rs542505777 1364 dbSNP
rs1299031207 1366 dbSNP
rs1019688628 1367 dbSNP
rs964043964 1368 dbSNP
rs1294519337 1369 dbSNP
rs181902939 1371 dbSNP
rs1348689762 1382 dbSNP
rs530493944 1387 dbSNP
rs535152627 1388 dbSNP
rs1358716660 1401 dbSNP
rs1222557562 1403 dbSNP
rs1253193953 1407 dbSNP
rs1438889198 1410 dbSNP
rs982688331 1411 dbSNP
rs984070051 1412 dbSNP
rs1471341990 1414 dbSNP
rs916412485 1416 dbSNP
rs908375703 1417 dbSNP
rs1342660793 1419 dbSNP
rs1460665875 1426 dbSNP
rs970578554 1427 dbSNP
rs1209856680 1428 dbSNP
rs1398434700 1432 dbSNP
rs1391872056 1436 dbSNP
rs1255073221 1443 dbSNP
rs982296876 1446 dbSNP
rs1328142255 1449 dbSNP
rs926339638 1451 dbSNP
rs1235234840 1452 dbSNP
rs1046561720 1455 dbSNP
rs1334441190 1457 dbSNP
rs937720151 1458 dbSNP
rs375250790 1459 dbSNP
rs146403938 1460 dbSNP
rs989072239 1462 dbSNP
rs1195691562 1474 dbSNP
rs1249063727 1476 dbSNP
rs1481752801 1477 dbSNP
rs914913184 1481 dbSNP
rs894027605 1483 dbSNP
rs570442883 1484 dbSNP
rs1374549957 1488 dbSNP
rs1011106132 1489 dbSNP
rs139670813 1489 dbSNP
rs1368639281 1491 dbSNP
rs1430206535 1493 dbSNP
rs1298042342 1494 dbSNP
rs1313547515 1494 dbSNP
rs1327342259 1494 dbSNP
rs1394482317 1494 dbSNP
rs889269983 1494 dbSNP
rs947806796 1494 dbSNP
rs1289669348 1501 dbSNP
rs1367700121 1507 dbSNP
rs1212298227 1509 dbSNP
rs1280388434 1510 dbSNP
rs527515817 1511 dbSNP
rs868655179 1515 dbSNP
rs1179706233 1516 dbSNP
rs914875147 1517 dbSNP
rs1428828702 1524 dbSNP
rs1019422669 1526 dbSNP
rs546483243 1536 dbSNP
rs1388155813 1539 dbSNP
rs1436483331 1547 dbSNP
rs1174229458 1548 dbSNP
rs962153525 1557 dbSNP
rs1464629021 1558 dbSNP
rs1290796449 1563 dbSNP
rs1362924264 1565 dbSNP
rs1381931730 1567 dbSNP
rs1295837192 1569 dbSNP
rs1373708187 1573 dbSNP
rs993461855 1577 dbSNP
rs371242741 1580 dbSNP
rs568208171 1582 dbSNP
rs1303350547 1584 dbSNP
rs535379635 1592 dbSNP
rs1381909148 1594 dbSNP
rs1207426361 1595 dbSNP
rs1262048241 1597 dbSNP
rs1246663380 1600 dbSNP
rs1027646976 1613 dbSNP
rs952062528 1614 dbSNP
rs1214552912 1616 dbSNP
rs1194133752 1619 dbSNP
rs1394418022 1631 dbSNP
rs947619295 1634 dbSNP
rs1431445581 1646 dbSNP
rs556809193 1648 dbSNP
rs1041972336 1654 dbSNP
rs903385196 1657 dbSNP
rs1260945072 1659 dbSNP
rs1453292341 1660 dbSNP
rs984022530 1662 dbSNP
rs776230590 1663 dbSNP
rs1442122614 1664 dbSNP
rs569744359 1665 dbSNP
rs1325747363 1666 dbSNP
rs969600157 1667 dbSNP
rs866452754 1672 dbSNP
rs1041549190 1673 dbSNP
rs927665950 1674 dbSNP
rs1445714607 1676 dbSNP
rs899947799 1687 dbSNP
rs996860373 1689 dbSNP
rs1469602841 1692 dbSNP
rs1184124613 1706 dbSNP
rs1026952389 1709 dbSNP
rs1245978518 1715 dbSNP
rs952677470 1717 dbSNP
rs1004569900 1722 dbSNP
rs1405795343 1725 dbSNP
rs1487457057 1729 dbSNP
rs186887978 1731 dbSNP
rs1159999870 1741 dbSNP
rs1015496954 1745 dbSNP
rs970989218 1747 dbSNP
rs981983639 1755 dbSNP
rs11121447 1760 dbSNP
rs1325638874 1766 dbSNP
rs571867029 1769 dbSNP
rs959118904 1774 dbSNP
rs1334402943 1775 dbSNP
rs1348554468 1776 dbSNP
rs1052170225 1782 dbSNP
rs559051147 1785 dbSNP
rs577268055 1796 dbSNP
rs989189082 1798 dbSNP
rs914948723 1803 dbSNP
rs1285891707 1809 dbSNP
rs946414491 1810 dbSNP
rs769486990 1812 dbSNP
rs1233584297 1815 dbSNP
rs1288850208 1821 dbSNP
rs189741314 1822 dbSNP
rs772983921 1823 dbSNP
rs553305714 1840 dbSNP
rs944830245 1846 dbSNP
rs1330717310 1847 dbSNP
rs1482733926 1858 dbSNP
rs1180109297 1859 dbSNP
rs545582220 1862 dbSNP
rs1475647372 1867 dbSNP
rs1162935158 1868 dbSNP
rs1041232286 1873 dbSNP
rs74551580 1882 dbSNP
rs1212763693 1890 dbSNP
rs1027761913 1895 dbSNP
rs780484024 1895 dbSNP
rs375797456 1896 dbSNP
rs1305626663 1900 dbSNP
rs1356866738 1910 dbSNP
rs1414985998 1920 dbSNP
rs1231656403 1924 dbSNP
rs887767543 1926 dbSNP
rs144424797 1928 dbSNP
rs1376631475 1929 dbSNP
rs1216119267 1930 dbSNP
rs111617052 1933 dbSNP
rs1341360885 1937 dbSNP
rs766279626 1945 dbSNP
rs747432437 1946 dbSNP
rs142123165 1956 dbSNP
rs181155984 1957 dbSNP
rs1187048307 1958 dbSNP
rs768659620 1959 dbSNP
rs78660120 1961 dbSNP
rs1048462547 1968 dbSNP
rs1479551235 1969 dbSNP
rs1176000791 1970 dbSNP
rs576234462 1973 dbSNP
rs1405001766 1976 dbSNP
rs1414825173 1980 dbSNP
rs1376700890 1989 dbSNP
rs888474446 1992 dbSNP
rs759547068 1993 dbSNP
rs1333019665 1994 dbSNP
rs1352658498 1999 dbSNP
rs1441424014 2002 dbSNP
rs544627851 2006 dbSNP
rs1432541422 2010 dbSNP
rs1270531847 2014 dbSNP
rs1364245714 2020 dbSNP
rs1034853063 2024 dbSNP
rs372775824 2032 dbSNP
rs956787931 2041 dbSNP
rs1199947160 2045 dbSNP
rs530560290 2048 dbSNP
rs781229756 2049 dbSNP
rs545477928 2054 dbSNP
rs1247761871 2056 dbSNP
rs1003836168 2061 dbSNP
rs12139340 2063 dbSNP
rs1195994213 2066 dbSNP
rs1271377405 2071 dbSNP
rs1396221305 2071 dbSNP
rs1478028877 2074 dbSNP
rs1171477367 2085 dbSNP
rs148640480 2088 dbSNP
rs1205860562 2098 dbSNP
rs959189998 2100 dbSNP
rs989264233 2102 dbSNP
rs1387577971 2103 dbSNP
rs1432655365 2106 dbSNP
rs528186251 2109 dbSNP
rs546643173 2116 dbSNP
rs764030060 2118 dbSNP
rs977803878 2122 dbSNP
rs753965192 2123 dbSNP
rs757416910 2128 dbSNP
rs976934888 2131 dbSNP
rs921473533 2137 dbSNP
rs932807445 2139 dbSNP
rs1174067864 2144 dbSNP
rs1048484267 2145 dbSNP
rs368536481 2146 dbSNP
rs529032296 2150 dbSNP
rs1372402986 2151 dbSNP
rs1254090317 2152 dbSNP
rs944967574 2171 dbSNP
rs1041063430 2174 dbSNP
rs1375391493 2181 dbSNP
rs897973692 2184 dbSNP
rs1159371459 2185 dbSNP
rs1410777254 2187 dbSNP
rs1402536216 2197 dbSNP
rs1455376272 2199 dbSNP
rs142035652 2200 dbSNP
rs906486977 2201 dbSNP
rs1049148394 2202 dbSNP
rs779336824 2204 dbSNP
rs373678062 2205 dbSNP
rs1287888380 2209 dbSNP
rs1229710960 2214 dbSNP
rs1235428321 2217 dbSNP
rs1022974176 2220 dbSNP
rs895009939 2220 dbSNP
rs1010727627 2223 dbSNP
rs1022114299 2226 dbSNP
rs1253306692 2227 dbSNP
rs1438980879 2228 dbSNP
rs907232671 2242 dbSNP
rs1003460892 2246 dbSNP
rs1035373117 2250 dbSNP
rs956509270 2251 dbSNP
rs375546406 2256 dbSNP
rs987952565 2265 dbSNP
rs1191315233 2269 dbSNP
rs1240075708 2277 dbSNP
rs1474956939 2278 dbSNP
rs999651058 2296 dbSNP
rs185407370 2297 dbSNP
rs539299385 2306 dbSNP
rs1416819138 2311 dbSNP
rs1313735208 2313 dbSNP
rs1340190907 2319 dbSNP
rs1391923134 2321 dbSNP
rs1243080520 2324 dbSNP
rs1422714837 2325 dbSNP
rs1343484853 2327 dbSNP
rs986316819 2333 dbSNP
rs910214831 2334 dbSNP
rs966099007 2348 dbSNP
rs748180479 2350 dbSNP
rs919518314 2360 dbSNP
rs1406683869 2361 dbSNP
rs547353392 2370 dbSNP
rs1185132170 2372 dbSNP
rs1325563798 2374 dbSNP
rs151142088 2382 dbSNP
rs1300329416 2383 dbSNP
rs954270529 2390 dbSNP
rs1381170758 2396 dbSNP
rs750796123 2401 dbSNP
rs1167925168 2404 dbSNP
rs530237306 2405 dbSNP
rs940121494 2406 dbSNP
rs139376790 2415 dbSNP
rs1401767397 2417 dbSNP
rs1394566540 2418 dbSNP
rs1358562494 2422 dbSNP
rs1037519712 2424 dbSNP
rs140131812 2434 dbSNP
rs1228262411 2437 dbSNP
rs1296071249 2439 dbSNP
rs939321588 2454 dbSNP
rs1055072670 2455 dbSNP
rs1465551710 2463 dbSNP
rs1256144886 2465 dbSNP
rs1188930139 2468 dbSNP
rs1198418906 2469 dbSNP
rs189655186 2472 dbSNP
rs1009320179 2473 dbSNP
rs1442649795 2480 dbSNP
rs570745942 2490 dbSNP
rs12033711 2495 dbSNP
rs1010799891 2500 dbSNP
rs1176863795 2504 dbSNP
rs967892752 2507 dbSNP
rs1007290544 2515 dbSNP
rs1473492893 2517 dbSNP
rs1389777837 2519 dbSNP
rs1043577289 2520 dbSNP
rs902307639 2535 dbSNP
rs1319051404 2537 dbSNP
rs3087919 2543 dbSNP
rs1019104768 2544 dbSNP
rs976173903 2547 dbSNP
rs1383767696 2551 dbSNP
rs1457483156 2552 dbSNP
rs1311142140 2563 dbSNP
rs919472061 2564 dbSNP
rs950954318 2570 dbSNP
rs965761259 2573 dbSNP
rs995815594 2584 dbSNP
rs183396168 2588 dbSNP
rs1028585006 2606 dbSNP
rs1404377749 2613 dbSNP
rs954299846 2619 dbSNP
rs555179974 2620 dbSNP
rs985076762 2640 dbSNP
rs144360129 2641 dbSNP
rs868196377 2641 dbSNP
rs747474242 2644 dbSNP
rs1161480759 2646 dbSNP
rs909378006 2646 dbSNP
rs984298060 2655 dbSNP
rs910090103 2657 dbSNP
rs1456975898 2659 dbSNP
rs961835115 2665 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions TZM-bl
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM1462574. RNA binding protein: AGO2. Condition:TZM-bl ami BaL ...

- Whisnant AW; Bogerd HP; Flores O; Ho P; et al., 2013, mBio.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' cuuguAUU--GUGCCUAUUGGAGa 5'
               ||:  ||| | ||||||| 
Target 5' -----UAGCUCACUG-UAACCUCa 3'
 		1 - 18
Article - Whisnant AW; Bogerd HP; Flores O; Ho P; et al.
- mBio, 2013
UNLABELLED: The question of how HIV-1 interfaces with cellular microRNA (miRNA) biogenesis and effector mechanisms has been highly controversial. Here, we first used deep sequencing of small RNAs present in two different infected cell lines (TZM-bl and C8166) and two types of primary human cells (CD4(+) peripheral blood mononuclear cells [PBMCs] and macrophages) to unequivocally demonstrate that HIV-1 does not encode any viral miRNAs. Perhaps surprisingly, we also observed that infection of T cells by HIV-1 has only a modest effect on the expression of cellular miRNAs at early times after infection. Comprehensive analysis of miRNA binding to the HIV-1 genome using the photoactivatable ribonucleoside-induced cross-linking and immunoprecipitation (PAR-CLIP) technique revealed several binding sites for cellular miRNAs, a subset of which were shown to be capable of mediating miRNA-mediated repression of gene expression. However, the main finding from this analysis is that HIV-1 transcripts are largely refractory to miRNA binding, most probably due to extensive viral RNA secondary structure. Together, these data demonstrate that HIV-1 neither encodes viral miRNAs nor strongly influences cellular miRNA expression, at least early after infection, and imply that HIV-1 transcripts have evolved to avoid inhibition by preexisting cellular miRNAs by adopting extensive RNA secondary structures that occlude most potential miRNA binding sites. IMPORTANCE: MicroRNAs (miRNAs) are a ubiquitous class of small regulatory RNAs that serve as posttranscriptional regulators of gene expression. Previous work has suggested that HIV-1 might subvert the function of the cellular miRNA machinery by expressing viral miRNAs or by dramatically altering the level of cellular miRNA expression. Using very sensitive approaches, we now demonstrate that neither of these ideas is in fact correct. Moreover, HIV-1 transcripts appear to largely avoid regulation by cellular miRNAs by adopting an extensive RNA secondary structure that occludes the ability of cellular miRNAs to interact with viral mRNAs. Together, these data suggest that HIV-1, rather than seeking to control miRNA function in infected cells, has instead evolved a mechanism to become largely invisible to cellular miRNA effector mechanisms.
LinkOut: [PMID: 23592263]
CLIP-seq Support 1 for dataset GSM1462574
Method / RBP PAR-CLIP / AGO2
Cell line / Condition TZM-bl / TZM-bl ami BaL
Location of target site ENST00000302692.6 | 3UTR | UAGCUCACUGUAACCUCAAACUCCUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23592263 / GSE59944
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
91 hsa-miR-655-5p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT080691 KIAA1468 KIAA1468 2 2
MIRT095086 SEC24A SEC24 homolog A, COPII coat complex component 2 4
MIRT122450 SMIM13 small integral membrane protein 13 2 2
MIRT214635 SMAD5 SMAD family member 5 2 4
MIRT268267 CCND1 cyclin D1 2 2
MIRT312418 GRPEL2 GrpE like 2, mitochondrial 2 2
MIRT329008 DSTN destrin, actin depolymerizing factor 2 2
MIRT329824 PDCD4 programmed cell death 4 2 4
MIRT389635 LRRC58 leucine rich repeat containing 58 2 6
MIRT443969 FAM198B family with sequence similarity 198 member B 2 2
MIRT444080 C12orf73 chromosome 12 open reading frame 73 2 2
MIRT444886 TMEM196 transmembrane protein 196 2 2
MIRT445506 CRNKL1 crooked neck pre-mRNA splicing factor 1 2 4
MIRT446292 ACSL3 acyl-CoA synthetase long chain family member 3 2 2
MIRT446462 THAP1 THAP domain containing 1 2 2
MIRT446472 THUMPD3 THUMP domain containing 3 2 2
MIRT447413 MED21 mediator complex subunit 21 2 2
MIRT447491 KIAA1715 lunapark, ER junction formation factor 2 2
MIRT448965 CDADC1 cytidine and dCMP deaminase domain containing 1 2 2
MIRT449602 INIP INTS3 and NABP interacting protein 2 2
MIRT449607 PRPF4 pre-mRNA processing factor 4 2 2
MIRT449737 TAB2 TGF-beta activated kinase 1/MAP3K7 binding protein 2 2 2
MIRT451668 KRT8 keratin 8 2 4
MIRT452424 QDPR quinoid dihydropteridine reductase 2 2
MIRT455187 AGTRAP angiotensin II receptor associated protein 2 2
MIRT456059 SLC25A28 solute carrier family 25 member 28 2 2
MIRT456488 SERAC1 serine active site containing 1 2 2
MIRT456631 ARMCX6 armadillo repeat containing, X-linked 6 2 2
MIRT459621 SLC25A33 solute carrier family 25 member 33 2 2
MIRT461162 SLC11A2 solute carrier family 11 member 2 2 4
MIRT461990 PACSIN1 protein kinase C and casein kinase substrate in neurons 1 2 2
MIRT463149 ZNF385A zinc finger protein 385A 2 4
MIRT463465 ZC3HAV1L zinc finger CCCH-type containing, antiviral 1 like 2 2
MIRT463801 XPOT exportin for tRNA 2 2
MIRT464010 WDR26 WD repeat domain 26 2 2
MIRT465302 TRIB1 tribbles pseudokinase 1 2 2
MIRT468837 RRM2 ribonucleotide reductase regulatory subunit M2 2 2
MIRT469132 RNF126 ring finger protein 126 2 2
MIRT469244 RHOB ras homolog family member B 2 2
MIRT472414 NCKAP1 NCK associated protein 1 2 2
MIRT472432 NCBP2 nuclear cap binding protein subunit 2 2 2
MIRT472808 MTMR12 myotubularin related protein 12 2 2
MIRT477893 DVL3 dishevelled segment polarity protein 3 2 4
MIRT477963 DPM2 dolichyl-phosphate mannosyltransferase subunit 2, regulatory 2 2
MIRT479258 CHSY1 chondroitin sulfate synthase 1 2 2
MIRT479718 CCNF cyclin F 2 2
MIRT480231 C9orf41 carnosine N-methyltransferase 1 2 2
MIRT482600 ABHD14B abhydrolase domain containing 14B 2 2
MIRT483096 TFPI tissue factor pathway inhibitor 2 2
MIRT484644 TBC1D5 TBC1 domain family member 5 2 4
MIRT488899 CLDND1 claudin domain containing 1 2 2
MIRT491954 VPS52 VPS52, GARP complex subunit 2 2
MIRT496937 LBR lamin B receptor 2 2
MIRT498546 TMEM30B transmembrane protein 30B 2 2
MIRT501778 NRBF2 nuclear receptor binding factor 2 2 6
MIRT516286 DBT dihydrolipoamide branched chain transacylase E2 2 2
MIRT516351 GABPB1 GA binding protein transcription factor beta subunit 1 2 2
MIRT516751 ZNF100 zinc finger protein 100 2 2
MIRT517939 ZNF431 zinc finger protein 431 2 4
MIRT518295 ZNF514 zinc finger protein 514 2 4
MIRT518515 CASP10 caspase 10 2 2
MIRT519017 NOA1 nitric oxide associated 1 2 2
MIRT519171 SCO1 SCO1, cytochrome c oxidase assembly protein 2 2
MIRT519470 SPTLC2 serine palmitoyltransferase long chain base subunit 2 2 2
MIRT521029 SLC30A5 solute carrier family 30 member 5 2 2
MIRT521251 SAMD8 sterile alpha motif domain containing 8 2 2
MIRT521682 PRKAR2A protein kinase cAMP-dependent type II regulatory subunit alpha 2 2
MIRT529386 SKP1 S-phase kinase associated protein 1 2 2
MIRT545507 NAP1L1 nucleosome assembly protein 1 like 1 2 2
MIRT549655 RSL1D1 ribosomal L1 domain containing 1 2 2
MIRT551041 CTSB cathepsin B 2 4
MIRT551441 ZNF490 zinc finger protein 490 2 4
MIRT554778 RHEBP1 RHEB pseudogene 1 2 4
MIRT565793 SEC14L5 SEC14 like lipid binding 5 2 2
MIRT566727 MSL2 MSL complex subunit 2 2 2
MIRT574668 HNRNPDL heterogeneous nuclear ribonucleoprotein D like 2 2
MIRT610128 DENND5B DENN domain containing 5B 2 2
MIRT624919 FBXW2 F-box and WD repeat domain containing 2 2 2
MIRT641830 TRIM71 tripartite motif containing 71 2 2
MIRT662165 IFNAR2 interferon alpha and beta receptor subunit 2 2 2
MIRT667150 NRXN3 neurexin 3 2 2
MIRT689085 ADNP2 ADNP homeobox 2 2 2
MIRT696322 DCAF15 DDB1 and CUL4 associated factor 15 2 2
MIRT699062 SNX4 sorting nexin 4 2 2
MIRT703229 GOLGA1 golgin A1 2 2
MIRT705743 AMD1 adenosylmethionine decarboxylase 1 2 2
MIRT706087 HNRNPU heterogeneous nuclear ribonucleoprotein U 2 2
MIRT709288 MAPK8IP2 mitogen-activated protein kinase 8 interacting protein 2 2 2
MIRT711457 RNF145 ring finger protein 145 2 2
MIRT714708 PPP3CC protein phosphatase 3 catalytic subunit gamma 2 2
MIRT719871 CYP4F11 cytochrome P450 family 4 subfamily F member 11 2 2
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-655 Gefitinib approved 123631 Quantitative real-time PCR lung adenocarcinoma cells 24258346 2014 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-655 Cisplatin 5460033 NSC119875 approved sensitive cell line (A2780)
hsa-mir-655 Androstenedione 6128 NSC9563 resistant cell line (MCF-7)
hsa-mir-655 Ceritinib 57379345 NSC776422 approved resistant cell line (H3122)
hsa-miR-655-5p Temozolomide 5394 NSC362856 approved sensitive cell line (U251)
hsa-miR-655-5p Gefitinib 123631 NSC715055 approved sensitive cell line (PC9)
hsa-miR-655-5p Gefitinib 123631 NSC715055 approved resistant cell line (HCC827)
hsa-miR-655-5p Ceritinib 57379345 NSC776422 approved resistant cell line (H3122)

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