miRTarBase - #MIRT459784


—
pre-miRNA Information
pre-miRNA hsa-mir-4524b   
Genomic Coordinates chr17: 69099542 - 69099656
Description Homo sapiens miR-4524b stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-4524b-3p
Sequence 66| GAGACAGGUUCAUGCUGCUA |85
Evidence Experimental
Experiments SOLiD
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1263495678 1 dbSNP
rs1350790266 9 dbSNP
rs1322445998 14 dbSNP
Putative Targets

Gene Information
Gene Symbol IDH3A   
Synonyms -
Description isocitrate dehydrogenase 3 (NAD(+)) alpha
Transcript NM_005530   
Expression
Putative miRNA Targets on IDH3A
3'UTR of IDH3A
(miRNA target sites are highlighted)		 
>IDH3A|NM_005530|3'UTR
   1 CACTTCTACAACTGGCATTTACATCAGTCACTCTAAATGGACACCACATGAACCTCTGTTTAGAATACCTACGTATGTAT
  81 GCATTGGTTTGCTTGTTTCTTGACAGTACATTTTTAGATCTGGCCTTTTCTTAACAAAATCTGTGCAAAAGATGCAGGTG
 161 GATGTCCCTAGGTCTGTTTTCAAAGAACTTTTTCCAAGTGCTTGTTTTATTTATTAAGTGTCTACCTGGTAAATGTTTTT
 241 TTTGTAAACTCTGAGTGGACTGTATCATTTGCTATTCTAAACCATTTTACACTTAAGTTAAAATAGTTTCTCTTCAGCTG
 321 TAAATAACAGGATACAGAATTAACAAGAGAAAATGTCTAACTTTTTAAGAAAAACCTTATTTTCTTCGGTTTTTGAAAAA
 401 CATAATGGAAATAAAACAGGATATTGACATAATAGCACAAAATGACACTCTTCTAAAACTAAATGGGCACAAGAGAATTT
 481 TCCTGGGAAAGTTCACATCAAAAAGAGTGAATGTGGTATATTTCTAAATGATATGGAAAATAGAGACAGATTTGTCCTTT
 561 ACAGAAATTACTGAGTGTGAATAAAAACTTCAGATCCAAGAAATATATAATGAGAGATATAATTTTTGTTAATAAGACAA
 641 AGGTAATATATTGGATACAAAGACACAAATGTATTGTGTGTTCAATTATTTTGTTGTCTTGAGATTTAATATTCTTTCCA
 721 AGAGCTTTTAATGAAGCAGAGAGCTAGTACTTCATTTTCACTGGATACATTTTCAGCATCATGAGTTGTCACAGCCTCTG
 801 AGCCCCTGATCTGAAGCCAGAAGGGCTGAGTGTATTGTAAACTTATTCTTGCATGTTGCTGTCTGGGAATGGACCACACT
 881 ACAGCAGGTAGTTCTGGGGGCGATACTGCCGAAAGGCCCGAACACATGTATTTTGGCTGCAATTGAGGAACTTGGGATGC
 961 TATTAATTTTGTATTTCAGCAACTGCCCCTTCTCCTATCCCAAAGCACCAATTACTGCCCTCTGCCTCAGCAGTACCAGT
1041 ATAAGATGACATTCCAAAGACTGGAGGCAACTCAGCCTGAGTTAATTCACAAAATTATGCCATGCTGGGGCTTGAGCTTG
1121 AGCTTGGGCTTAGGCTTGGGCTCAGCTTTTGACCCTCAGGCATCTCCTTTCCCTTCCTGTCTTCCTCTCCCTTCTCCTCT
1201 GCTGCAGCATGATTTTCTTAATCTTCAGACACTCACTATTTTCATGAACAGTTACCCTCTGTCCCCACAACCAAAGACAA
1281 CTCATGGCCTCCTTTGGCCCTTGTGTAACATTGCAAACCTGTGGCTTTGCAAAATGTACCCAGGTCACAAGGGGATTTTT
1361 TTTTTTTTAGCAATGATATCCCTGTCTGGGTCACTTTTTAAGCTTGTAACCGCCCCCCCAGACTTATAATCTTAAATGTA
1441 TTTTCCTTTGTTTAAGCTGCTGCTTCCTCTGTTTCATTGGATTGTGCCAGTTATCAGTGGCTCTTGGGTTCAAAGTAATA
1521 AAGAATTCCAAAACTGAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' aucGUCG-UACU-U--GGACAGAg 5'
             :||| |||| |  ||||||| 
Target 5' tttTAGCAATGATATCCCTGTCTg 3'
 1365 - 1388 155.00 -15.10
2 
miRNA  3' aucgucguacuuGGACAGAg 5'
                      ||||||| 
Target 5' ctcctttcccttCCTGTCTt 3'
 1164 - 1183 140.00 -10.70
3 
miRNA  3' aucGUCGUACUU--GGACAGAg 5'
             || ||||||  :||||:| 
Target 5' cacCA-CATGAACCTCTGTTTa 3'
 42 - 62 130.00 -13.90
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30520973 34 COSMIC
COSN31567142 55 COSMIC
COSN30470184 57 COSMIC
COSN30191374 109 COSMIC
COSN31573754 118 COSMIC
COSN30191577 137 COSMIC
COSN25949833 346 COSMIC
COSN7249336 407 COSMIC
COSN28291577 422 COSMIC
COSN25403517 675 COSMIC
COSN9639239 690 COSMIC
COSN27739779 743 COSMIC
COSN20309992 870 COSMIC
COSN31961115 921 COSMIC
COSN23987216 1118 COSMIC
COSN505788 1369 COSMIC
COSN6073249 1458 COSMIC
COSN4763195 1693 COSMIC
COSN19658395 1843 COSMIC
COSN31541023 1874 COSMIC
COSN31546128 1978 COSMIC
COSN31593302 2011 COSMIC
COSN31593702 2060 COSMIC
COSN31593797 2248 COSMIC
COSN30137277 2354 COSMIC
COSN26964898 2372 COSMIC
COSN20058099 2397 COSMIC
COSN26964895 2398 COSMIC
COSN31497706 2414 COSMIC
COSN31498174 2431 COSMIC
COSM965319 2446 COSMIC
COSM1374758 2450 COSMIC
COSM7650647 2462 COSMIC
COSM8745957 2465 COSMIC
COSM8745896 2466 COSMIC
COSM238666 2485 COSMIC
COSM8825558 2505 COSMIC
COSM6592523 2511 COSMIC
COSM271082 2518 COSMIC
COSM8957260 2525 COSMIC
COSN30705104 2551 COSMIC
COSN19771423 2600 COSMIC
COSN22813184 2602 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1245519107 1 dbSNP
rs748785130 2 dbSNP
rs187282021 3 dbSNP
rs774280661 8 dbSNP
rs1461399476 16 dbSNP
rs761529617 22 dbSNP
rs1325526441 23 dbSNP
rs200899997 30 dbSNP
rs1207377201 33 dbSNP
rs1308943826 35 dbSNP
rs988186524 38 dbSNP
rs773141812 39 dbSNP
rs1351210746 42 dbSNP
rs761023185 45 dbSNP
rs766656068 51 dbSNP
rs1362678461 57 dbSNP
rs1317094623 59 dbSNP
rs934935790 69 dbSNP
rs543574237 73 dbSNP
rs1481039457 74 dbSNP
rs1355391789 80 dbSNP
rs913868834 81 dbSNP
rs570596164 83 dbSNP
rs922790097 84 dbSNP
rs932846633 94 dbSNP
rs1387421015 105 dbSNP
rs17674205 111 dbSNP
rs191256136 119 dbSNP
rs888230780 121 dbSNP
rs1179668247 135 dbSNP
rs1005711377 144 dbSNP
rs1251532308 151 dbSNP
rs1036706055 156 dbSNP
rs1353737072 160 dbSNP
rs1339831151 163 dbSNP
rs896782567 165 dbSNP
rs541461978 172 dbSNP
rs1310467169 186 dbSNP
rs1393222546 192 dbSNP
rs889063274 203 dbSNP
rs1346114007 205 dbSNP
rs1035327330 219 dbSNP
rs1408192367 220 dbSNP
rs1404253182 228 dbSNP
rs1274395269 232 dbSNP
rs1164667605 234 dbSNP
rs959261685 236 dbSNP
rs943315642 243 dbSNP
rs1012119269 245 dbSNP
rs1216555555 249 dbSNP
rs559674479 250 dbSNP
rs1250555589 256 dbSNP
rs1176299299 259 dbSNP
rs1481890062 261 dbSNP
rs1270561401 268 dbSNP
rs1223020194 269 dbSNP
rs1490123069 282 dbSNP
rs1263630161 288 dbSNP
rs1022132500 301 dbSNP
rs769286041 303 dbSNP
rs1317631089 314 dbSNP
rs1306442208 326 dbSNP
rs1296517975 328 dbSNP
rs530023091 332 dbSNP
rs968790155 338 dbSNP
rs1347684152 341 dbSNP
rs1303979698 348 dbSNP
rs1404727039 350 dbSNP
rs1307307648 357 dbSNP
rs1203513833 358 dbSNP
rs1040588040 362 dbSNP
rs1454725698 368 dbSNP
rs1294367656 371 dbSNP
rs528365705 377 dbSNP
rs924647802 377 dbSNP
rs901680187 388 dbSNP
rs976760641 389 dbSNP
rs878971221 406 dbSNP
rs1199623630 407 dbSNP
rs1490132481 408 dbSNP
rs922887490 415 dbSNP
rs932897653 421 dbSNP
rs1486182415 447 dbSNP
rs1260061398 450 dbSNP
rs1244493985 468 dbSNP
rs1325678643 485 dbSNP
rs993213293 489 dbSNP
rs1223080837 492 dbSNP
rs1026103761 518 dbSNP
rs1391885614 519 dbSNP
rs1383100484 533 dbSNP
rs1476084491 535 dbSNP
rs1319122827 542 dbSNP
rs1455189485 547 dbSNP
rs1407595124 551 dbSNP
rs887438774 552 dbSNP
rs1186761145 558 dbSNP
rs541997243 559 dbSNP
rs563492037 561 dbSNP
rs530591465 565 dbSNP
rs1418406343 567 dbSNP
rs760075287 576 dbSNP
rs1195135747 577 dbSNP
rs1428893151 586 dbSNP
rs1017173455 595 dbSNP
rs551972986 604 dbSNP
rs1037161496 620 dbSNP
rs1462727431 621 dbSNP
rs970015545 627 dbSNP
rs79037950 629 dbSNP
rs1365947038 633 dbSNP
rs1035557274 638 dbSNP
rs960867671 640 dbSNP
rs1343193576 642 dbSNP
rs1253277132 644 dbSNP
rs1228694574 648 dbSNP
rs528072993 649 dbSNP
rs546232709 652 dbSNP
rs1455017045 656 dbSNP
rs946707996 665 dbSNP
rs1056133621 666 dbSNP
rs979814943 667 dbSNP
rs1399701754 670 dbSNP
rs910571225 672 dbSNP
rs1389264149 674 dbSNP
rs1348240245 685 dbSNP
rs869224682 691 dbSNP
rs183417040 693 dbSNP
rs1364789162 694 dbSNP
rs536552087 696 dbSNP
rs554715362 704 dbSNP
rs1226460154 707 dbSNP
rs968256585 707 dbSNP
rs570171085 734 dbSNP
rs1440763790 742 dbSNP
rs1317681439 746 dbSNP
rs1040300671 749 dbSNP
rs1360548450 751 dbSNP
rs1228280790 756 dbSNP
rs182190107 757 dbSNP
rs929161832 759 dbSNP
rs1449209730 763 dbSNP
rs1032195566 768 dbSNP
rs753081258 782 dbSNP
rs1215933161 789 dbSNP
rs1314962499 793 dbSNP
rs956136917 797 dbSNP
rs1241011788 802 dbSNP
rs1463313034 803 dbSNP
rs1184989002 804 dbSNP
rs28425556 812 dbSNP
rs1047494043 819 dbSNP
rs977192832 824 dbSNP
rs1391568022 826 dbSNP
rs1369520745 833 dbSNP
rs922603733 838 dbSNP
rs1385855454 846 dbSNP
rs1426296779 846 dbSNP
rs1162509666 847 dbSNP
rs954298045 854 dbSNP
rs1365571168 856 dbSNP
rs11631060 863 dbSNP
rs537679564 864 dbSNP
rs1482882019 868 dbSNP
rs910068510 879 dbSNP
rs1443742808 884 dbSNP
rs1490596780 890 dbSNP
rs1161417644 892 dbSNP
rs1030322970 901 dbSNP
rs941503326 902 dbSNP
rs972909547 907 dbSNP
rs887554965 911 dbSNP
rs117706925 912 dbSNP
rs1349557294 913 dbSNP
rs939111699 914 dbSNP
rs1023027649 920 dbSNP
rs187905455 921 dbSNP
rs1365897603 929 dbSNP
rs546461591 930 dbSNP
rs1322834847 935 dbSNP
rs1403576178 935 dbSNP
rs905528147 937 dbSNP
rs541023883 943 dbSNP
rs767078890 944 dbSNP
rs1056142958 952 dbSNP
rs192802933 955 dbSNP
rs947964290 967 dbSNP
rs1035267835 983 dbSNP
rs537898428 986 dbSNP
rs557572186 987 dbSNP
rs527507361 992 dbSNP
rs755562201 995 dbSNP
rs1208875651 998 dbSNP
rs577565802 1004 dbSNP
rs574753886 1012 dbSNP
rs183739774 1023 dbSNP
rs968517001 1026 dbSNP
rs28616259 1036 dbSNP
rs879209125 1042 dbSNP
rs1346961925 1047 dbSNP
rs1353553479 1050 dbSNP
rs11072733 1057 dbSNP
rs1266951895 1060 dbSNP
rs1326371056 1063 dbSNP
rs910509815 1064 dbSNP
rs1386485687 1069 dbSNP
rs954020288 1074 dbSNP
rs1470447416 1088 dbSNP
rs1243324052 1089 dbSNP
rs1228136928 1104 dbSNP
rs985695910 1109 dbSNP
rs1476589103 1110 dbSNP
rs964776908 1112 dbSNP
rs1017165923 1115 dbSNP
rs1464065855 1116 dbSNP
rs962982813 1123 dbSNP
rs973349039 1124 dbSNP
rs1277473305 1126 dbSNP
rs1217268618 1135 dbSNP
rs137878326 1137 dbSNP
rs1298274839 1139 dbSNP
rs1434232406 1140 dbSNP
rs939103462 1141 dbSNP
rs976403050 1142 dbSNP
rs142503923 1146 dbSNP
rs777265245 1151 dbSNP
rs1358869054 1159 dbSNP
rs1174135716 1168 dbSNP
rs3087998 1172 dbSNP
rs1047565701 1177 dbSNP
rs1455660895 1178 dbSNP
rs1245497725 1179 dbSNP
rs947724924 1179 dbSNP
rs1184972462 1194 dbSNP
rs570130079 1197 dbSNP
rs1236552418 1205 dbSNP
rs1207530688 1233 dbSNP
rs903803802 1239 dbSNP
rs573229099 1246 dbSNP
rs1227366312 1264 dbSNP
rs561369490 1265 dbSNP
rs1317065550 1267 dbSNP
rs1332672313 1272 dbSNP
rs530295920 1276 dbSNP
rs548451487 1279 dbSNP
rs138704770 1289 dbSNP
rs537237701 1315 dbSNP
rs1301339677 1320 dbSNP
rs1444585763 1321 dbSNP
rs1371364074 1331 dbSNP
rs941733533 1334 dbSNP
rs1044157442 1345 dbSNP
rs1387637759 1349 dbSNP
rs901643010 1352 dbSNP
rs1423916733 1353 dbSNP
rs998239897 1355 dbSNP
rs1252067167 1356 dbSNP
rs1362024859 1356 dbSNP
rs1481440894 1356 dbSNP
rs557937344 1356 dbSNP
rs79522094 1356 dbSNP
rs77251250 1357 dbSNP
rs76863632 1369 dbSNP
rs75891888 1370 dbSNP
rs552746905 1372 dbSNP
rs1245365633 1377 dbSNP
rs1029680585 1378 dbSNP
rs905517297 1380 dbSNP
rs1288227179 1381 dbSNP
rs1225529304 1385 dbSNP
rs141266356 1412 dbSNP
rs1006876436 1413 dbSNP
rs1287892475 1413 dbSNP
rs34764788 1413 dbSNP
rs1056630052 1415 dbSNP
rs1016931601 1418 dbSNP
rs1263185926 1419 dbSNP
rs187922509 1420 dbSNP
rs1198360187 1424 dbSNP
rs1420345021 1424 dbSNP
rs1180926630 1426 dbSNP
rs537186662 1428 dbSNP
rs772281779 1445 dbSNP
rs968252872 1448 dbSNP
rs1001350449 1450 dbSNP
rs1488143780 1460 dbSNP
rs1438124327 1465 dbSNP
rs992309320 1469 dbSNP
rs1181408496 1472 dbSNP
rs1329870429 1484 dbSNP
rs916362027 1486 dbSNP
rs969118164 1489 dbSNP
rs1347589621 1498 dbSNP
rs1481357095 1499 dbSNP
rs1201763753 1522 dbSNP
rs1430057567 1523 dbSNP
rs1386552711 1542 dbSNP
rs1465741896 1555 dbSNP
rs192351606 1562 dbSNP
rs1291074048 1563 dbSNP
rs1170970993 1569 dbSNP
rs1388659849 1573 dbSNP
rs574867382 1580 dbSNP
rs535882461 1581 dbSNP
rs1307785146 1610 dbSNP
rs74024181 1621 dbSNP
rs935253406 1622 dbSNP
rs747324123 1627 dbSNP
rs575537981 1629 dbSNP
rs184613469 1634 dbSNP
rs1267635858 1637 dbSNP
rs149798673 1649 dbSNP
rs1339628655 1653 dbSNP
rs770883511 1654 dbSNP
rs983367784 1655 dbSNP
rs1204222594 1661 dbSNP
rs923117701 1665 dbSNP
rs561913754 1666 dbSNP
rs1298398553 1669 dbSNP
rs941906148 1678 dbSNP
rs776740496 1690 dbSNP
rs927093964 1693 dbSNP
rs938445209 1694 dbSNP
rs1056704557 1712 dbSNP
rs765075940 1713 dbSNP
rs891468147 1729 dbSNP
rs1197051869 1731 dbSNP
rs1403911795 1738 dbSNP
rs1172743442 1740 dbSNP
rs1465378995 1745 dbSNP
rs1375050977 1747 dbSNP
rs190101483 1748 dbSNP
rs1170219020 1749 dbSNP
rs1038782316 1750 dbSNP
rs750626725 1755 dbSNP
rs759985378 1756 dbSNP
rs1200034193 1761 dbSNP
rs1257138602 1761 dbSNP
rs1009741934 1766 dbSNP
rs1427129342 1769 dbSNP
rs3743081 1783 dbSNP
rs1229568192 1785 dbSNP
rs1342145067 1787 dbSNP
rs1296037647 1793 dbSNP
rs994845331 1799 dbSNP
rs904017710 1800 dbSNP
rs1334436997 1804 dbSNP
rs756377836 1808 dbSNP
rs1395137397 1812 dbSNP
rs770316460 1818 dbSNP
rs1384521659 1821 dbSNP
rs1430166362 1821 dbSNP
rs79914653 1822 dbSNP
rs1001066320 1833 dbSNP
rs1166573056 1835 dbSNP
rs1473827906 1835 dbSNP
rs1018091665 1851 dbSNP
rs1186891506 1853 dbSNP
rs1440957534 1855 dbSNP
rs900555286 1862 dbSNP
rs1254227297 1864 dbSNP
rs1326722427 1868 dbSNP
rs997618634 1873 dbSNP
rs1227191724 1877 dbSNP
rs1295145765 1878 dbSNP
rs1361249557 1881 dbSNP
rs1246663273 1886 dbSNP
rs960933037 1894 dbSNP
rs1030298319 1896 dbSNP
rs1284333282 1918 dbSNP
rs1357634653 1918 dbSNP
rs572825115 1919 dbSNP
rs1338407531 1920 dbSNP
rs1208177442 1924 dbSNP
rs1410220314 1936 dbSNP
rs1206929587 1939 dbSNP
rs1306135679 1941 dbSNP
rs1369662995 1941 dbSNP
rs969129745 1944 dbSNP
rs775762025 1945 dbSNP
rs181674417 1946 dbSNP
rs1471847878 1955 dbSNP
rs963524633 1957 dbSNP
rs1446786512 1958 dbSNP
rs1183108011 1971 dbSNP
rs979932661 1973 dbSNP
rs927139687 1974 dbSNP
rs1452756852 1975 dbSNP
rs577396557 1977 dbSNP
rs561481991 1978 dbSNP
rs1208733760 1984 dbSNP
rs1269648751 1985 dbSNP
rs139205870 1989 dbSNP
rs550200995 1996 dbSNP
rs1159850898 1997 dbSNP
rs541635711 1999 dbSNP
rs1042602016 2010 dbSNP
rs904132695 2011 dbSNP
rs1318072808 2012 dbSNP
rs1390877968 2017 dbSNP
rs1049436 2023 dbSNP
rs1159962391 2031 dbSNP
rs1456960238 2032 dbSNP
rs1410020116 2038 dbSNP
rs764573552 2046 dbSNP
rs1039178739 2047 dbSNP
rs900670495 2051 dbSNP
rs910350262 2054 dbSNP
rs1311710756 2056 dbSNP
rs942798925 2060 dbSNP
rs997564664 2067 dbSNP
rs1030452292 2068 dbSNP
rs886434883 2069 dbSNP
rs1241085882 2070 dbSNP
rs1208783443 2072 dbSNP
rs538957030 2078 dbSNP
rs1281689958 2080 dbSNP
rs1004909223 2081 dbSNP
rs563788186 2082 dbSNP
rs1246374456 2094 dbSNP
rs1016693334 2097 dbSNP
rs1321374017 2104 dbSNP
rs1047496284 2108 dbSNP
rs1255884037 2121 dbSNP
rs1386739084 2126 dbSNP
rs1178437420 2131 dbSNP
rs896779542 2138 dbSNP
rs3825847 2140 dbSNP
rs1171151290 2141 dbSNP
rs1451928337 2143 dbSNP
rs1184513434 2147 dbSNP
rs751840285 2156 dbSNP
rs1249173202 2160 dbSNP
rs980430875 2164 dbSNP
rs1188714365 2166 dbSNP
rs1456202399 2170 dbSNP
rs1240016079 2171 dbSNP
rs1023818571 2183 dbSNP
rs767683321 2186 dbSNP
rs969517741 2190 dbSNP
rs1231790601 2193 dbSNP
rs1034155964 2196 dbSNP
rs1032117284 2203 dbSNP
rs1227786830 2207 dbSNP
rs1466228111 2213 dbSNP
rs1359901425 2222 dbSNP
rs1302108858 2224 dbSNP
rs765761348 2239 dbSNP
rs1376625701 2242 dbSNP
rs552465923 2246 dbSNP
rs1307572978 2247 dbSNP
rs149534543 2253 dbSNP
rs1358775788 2255 dbSNP
rs992534403 2256 dbSNP
rs1351213458 2272 dbSNP
rs1432010402 2273 dbSNP
rs913007856 2279 dbSNP
rs945703463 2280 dbSNP
rs978421978 2281 dbSNP
rs925627524 2311 dbSNP
rs1416822842 2321 dbSNP
rs1183073746 2326 dbSNP
rs1029911735 2328 dbSNP
rs1266306543 2329 dbSNP
rs753432837 2338 dbSNP
rs11556085 2342 dbSNP
rs1483883406 2348 dbSNP
rs535264699 2352 dbSNP
rs1204298194 2353 dbSNP
rs1305658391 2355 dbSNP
rs910402458 2366 dbSNP
rs1228946611 2375 dbSNP
rs1255772829 2378 dbSNP
rs1412078875 2384 dbSNP
rs1371505394 2387 dbSNP
rs1487449344 2389 dbSNP
rs376109337 2390 dbSNP
rs941896452 2392 dbSNP
rs199991915 2393 dbSNP
rs765675038 2395 dbSNP
rs753303647 2397 dbSNP
rs368273559 2398 dbSNP
rs1454665684 2399 dbSNP
rs778150048 2404 dbSNP
rs1358178368 2405 dbSNP
rs1182037748 2406 dbSNP
rs1418731943 2407 dbSNP
rs751899344 2408 dbSNP
rs372364654 2409 dbSNP
rs1384997300 2414 dbSNP
rs375386246 2415 dbSNP
rs1336097645 2416 dbSNP
rs1267137394 2417 dbSNP
rs1242001672 2418 dbSNP
rs754456068 2425 dbSNP
rs147470279 2426 dbSNP
rs1216247687 2432 dbSNP
rs748188156 2433 dbSNP
rs1489534615 2434 dbSNP
rs772108798 2437 dbSNP
rs949630228 2439 dbSNP
rs1321135400 2442 dbSNP
rs773160296 2443 dbSNP
rs771280821 2444 dbSNP
rs201874784 2452 dbSNP
rs1378860386 2454 dbSNP
rs545427158 2455 dbSNP
rs1351317254 2468 dbSNP
rs778868128 2470 dbSNP
rs765424200 2471 dbSNP
rs775401161 2475 dbSNP
rs1292466827 2478 dbSNP
rs763501280 2490 dbSNP
rs764537595 2491 dbSNP
rs372529648 2493 dbSNP
rs1375949698 2497 dbSNP
rs1037669159 2498 dbSNP
rs539743362 2500 dbSNP
rs1313754309 2504 dbSNP
rs752742288 2505 dbSNP
rs751597856 2508 dbSNP
rs753588373 2511 dbSNP
rs375772785 2518 dbSNP
rs778529190 2522 dbSNP
rs201136052 2528 dbSNP
rs758437551 2534 dbSNP
rs777782663 2535 dbSNP
rs758124630 2537 dbSNP
rs373292255 2539 dbSNP
rs770905119 2542 dbSNP
rs11638547 2544 dbSNP
rs370953009 2546 dbSNP
rs1381678208 2548 dbSNP
rs1467106576 2550 dbSNP
rs769884974 2552 dbSNP
rs959849366 2555 dbSNP
rs775662194 2556 dbSNP
rs1453042066 2558 dbSNP
rs762981722 2559 dbSNP
rs1417014590 2561 dbSNP
rs1226255113 2562 dbSNP
rs77787593 2564 dbSNP
rs1297041027 2568 dbSNP
rs762283233 2569 dbSNP
rs1312093022 2572 dbSNP
rs1342964916 2574 dbSNP
rs573409049 2576 dbSNP
rs1020087155 2582 dbSNP
rs1029964026 2584 dbSNP
rs752704221 2584 dbSNP
rs1251274482 2604 dbSNP
rs1210657435 2609 dbSNP
rs1330158260 2612 dbSNP
rs1267673153 2618 dbSNP
rs1237355334 2621 dbSNP
rs754748815 2625 dbSNP
rs747175764 2633 dbSNP
rs1302629985 2638 dbSNP
rs1207113823 2643 dbSNP
rs1386751295 2646 dbSNP
rs954353575 2647 dbSNP
rs1323373646 2648 dbSNP
rs36035191 2662 dbSNP
rs139852452 2669 dbSNP
rs978919371 2676 dbSNP
rs1203559456 2677 dbSNP
rs1017502210 2680 dbSNP
rs1270420808 2683 dbSNP
rs868760241 2705 dbSNP
rs963616999 2727 dbSNP
rs771206969 2730 dbSNP
rs533344808 2740 dbSNP
rs1190298695 2741 dbSNP
rs1190601141 2742 dbSNP
rs781207142 2747 dbSNP
rs562523174 2755 dbSNP
rs930084554 2760 dbSNP
rs1484344181 2764 dbSNP
rs1257000381 2768 dbSNP
rs1169042739 2777 dbSNP
rs1232966951 2779 dbSNP
rs145485376 2783 dbSNP
rs1389254539 2791 dbSNP
rs1427744241 2801 dbSNP
rs147697701 2818 dbSNP
rs1351708501 2821 dbSNP
rs1229990039 2822 dbSNP
rs1437340401 2849 dbSNP
rs745949137 2850 dbSNP
rs1380208565 2852 dbSNP
rs34384673 2853 dbSNP
rs564650608 2853 dbSNP
rs1403888369 2856 dbSNP
rs1365838869 2861 dbSNP
rs1303282491 2875 dbSNP
rs982836315 2879 dbSNP
rs1230867979 2896 dbSNP
rs770224913 2899 dbSNP
rs933461847 2902 dbSNP
rs1170361432 2904 dbSNP
rs1051912345 2911 dbSNP
rs908044859 2928 dbSNP
rs775958279 2930 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions TZM-bl
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM1462574. RNA binding protein: AGO2. Condition:TZM-bl ami BaL ...

- Whisnant AW; Bogerd HP; Flores O; Ho P; et al., 2013, mBio.

Article - Whisnant AW; Bogerd HP; Flores O; Ho P; et al.
- mBio, 2013
UNLABELLED: The question of how HIV-1 interfaces with cellular microRNA (miRNA) biogenesis and effector mechanisms has been highly controversial. Here, we first used deep sequencing of small RNAs present in two different infected cell lines (TZM-bl and C8166) and two types of primary human cells (CD4(+) peripheral blood mononuclear cells [PBMCs] and macrophages) to unequivocally demonstrate that HIV-1 does not encode any viral miRNAs. Perhaps surprisingly, we also observed that infection of T cells by HIV-1 has only a modest effect on the expression of cellular miRNAs at early times after infection. Comprehensive analysis of miRNA binding to the HIV-1 genome using the photoactivatable ribonucleoside-induced cross-linking and immunoprecipitation (PAR-CLIP) technique revealed several binding sites for cellular miRNAs, a subset of which were shown to be capable of mediating miRNA-mediated repression of gene expression. However, the main finding from this analysis is that HIV-1 transcripts are largely refractory to miRNA binding, most probably due to extensive viral RNA secondary structure. Together, these data demonstrate that HIV-1 neither encodes viral miRNAs nor strongly influences cellular miRNA expression, at least early after infection, and imply that HIV-1 transcripts have evolved to avoid inhibition by preexisting cellular miRNAs by adopting extensive RNA secondary structures that occlude most potential miRNA binding sites. IMPORTANCE: MicroRNAs (miRNAs) are a ubiquitous class of small regulatory RNAs that serve as posttranscriptional regulators of gene expression. Previous work has suggested that HIV-1 might subvert the function of the cellular miRNA machinery by expressing viral miRNAs or by dramatically altering the level of cellular miRNA expression. Using very sensitive approaches, we now demonstrate that neither of these ideas is in fact correct. Moreover, HIV-1 transcripts appear to largely avoid regulation by cellular miRNAs by adopting an extensive RNA secondary structure that occludes the ability of cellular miRNAs to interact with viral mRNAs. Together, these data suggest that HIV-1, rather than seeking to control miRNA function in infected cells, has instead evolved a mechanism to become largely invisible to cellular miRNA effector mechanisms.
LinkOut: [PMID: 23592263]
CLIP-seq Support 1 for dataset GSM1462574
Method / RBP PAR-CLIP / AGO2
Cell line / Condition TZM-bl / TZM-bl ami BaL
Location of target site ENST00000299518.2 | 3UTR | UUCCUCUCCCUUCUCCUCUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23592263 / GSE59944
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
175 hsa-miR-4524b-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT064889 ZBTB18 zinc finger and BTB domain containing 18 2 2
MIRT075345 SF3B3 splicing factor 3b subunit 3 2 2
MIRT094174 PCGF3 polycomb group ring finger 3 2 6
MIRT100109 ABT1 activator of basal transcription 1 2 8
MIRT102242 HBP1 HMG-box transcription factor 1 2 2
MIRT124918 HCCS holocytochrome c synthase 2 2
MIRT140195 CHAC1 ChaC glutathione specific gamma-glutamylcyclotransferase 1 2 2
MIRT193891 HACD3 3-hydroxyacyl-CoA dehydratase 3 2 2
MIRT265634 LDHA lactate dehydrogenase A 2 2
MIRT303878 VAMP8 vesicle associated membrane protein 8 2 2
MIRT409756 CRTAP cartilage associated protein 2 4
MIRT441503 SPG20 spartin 2 6
MIRT446882 ZNF554 zinc finger protein 554 2 2
MIRT447093 COPRS coordinator of PRMT5 and differentiation stimulator 2 2
MIRT449987 AEN apoptosis enhancing nuclease 2 2
MIRT452116 IFITM1 interferon induced transmembrane protein 1 2 2
MIRT452654 ZNF33A zinc finger protein 33A 2 2
MIRT453886 IFRD1 interferon related developmental regulator 1 2 12
MIRT454143 FOXRED2 FAD dependent oxidoreductase domain containing 2 2 2
MIRT454501 SLC29A1 solute carrier family 29 member 1 (Augustine blood group) 2 2
MIRT456633 ARMCX6 armadillo repeat containing, X-linked 6 2 2
MIRT457021 ACADSB acyl-CoA dehydrogenase, short/branched chain 2 2
MIRT457055 NEGR1 neuronal growth regulator 1 2 2
MIRT457335 REG4 regenerating family member 4 2 2
MIRT457421 CASC5 kinetochore scaffold 1 2 2
MIRT457940 LCE1A late cornified envelope 1A 2 2
MIRT458486 RMI1 RecQ mediated genome instability 1 2 10
MIRT458662 PAGR1 PAXIP1 associated glutamate rich protein 1 2 12
MIRT459784 IDH3A isocitrate dehydrogenase 3 (NAD(+)) alpha 2 2
MIRT459864 SVOP SV2 related protein 2 2
MIRT460575 FEM1A fem-1 homolog A 2 2
MIRT460987 STK17B serine/threonine kinase 17b 2 2
MIRT462315 TMEM109 transmembrane protein 109 2 2
MIRT464407 URM1 ubiquitin related modifier 1 2 2
MIRT465148 TSC22D2 TSC22 domain family member 2 2 2
MIRT466312 TIMM22 translocase of inner mitochondrial membrane 22 2 2
MIRT466718 SYNJ2BP synaptojanin 2 binding protein 2 2
MIRT468258 SFXN4 sideroflexin 4 2 2
MIRT469140 RNF126 ring finger protein 126 2 2
MIRT471783 NUP153 nucleoporin 153 2 2
MIRT472506 NACC2 NACC family member 2 2 2
MIRT474588 KLF6 Kruppel like factor 6 2 2
MIRT475049 JOSD1 Josephin domain containing 1 2 2
MIRT476900 FBXO21 F-box protein 21 2 2
MIRT476972 FAM83G family with sequence similarity 83 member G 2 4
MIRT477433 EMP1 epithelial membrane protein 1 2 2
MIRT480334 C5orf51 chromosome 5 open reading frame 51 2 10
MIRT481179 AVL9 AVL9 cell migration associated 2 6
MIRT481693 AR androgen receptor 2 2
MIRT483280 HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 2 4
MIRT485775 B4GALT5 beta-1,4-galactosyltransferase 5 2 2
MIRT487424 CACNB1 calcium voltage-gated channel auxiliary subunit beta 1 2 2
MIRT488002 RXRB retinoid X receptor beta 2 2
MIRT488259 DNLZ DNL-type zinc finger 2 4
MIRT490360 DPYSL5 dihydropyrimidinase like 5 2 2
MIRT491593 USB1 U6 snRNA biogenesis phosphodiesterase 1 2 2
MIRT495269 IGF2BP1 insulin like growth factor 2 mRNA binding protein 1 2 4
MIRT495619 ZNF736 zinc finger protein 736 2 2
MIRT496167 ELP3 elongator acetyltransferase complex subunit 3 2 2
MIRT496250 GJB2 gap junction protein beta 2 2 2
MIRT496915 RTKN rhotekin 2 2
MIRT498713 PGAM5 PGAM family member 5, mitochondrial serine/threonine protein phosphatase 2 10
MIRT501106 SLC5A6 solute carrier family 5 member 6 2 4
MIRT501831 NCOA3 nuclear receptor coactivator 3 2 2
MIRT507142 GIGYF1 GRB10 interacting GYF protein 1 2 2
MIRT510991 PER1 period circadian clock 1 2 4
MIRT512283 ARHGDIA Rho GDP dissociation inhibitor alpha 2 6
MIRT513152 CSDC2 cold shock domain containing C2 2 2
MIRT513327 KCNMB1 potassium calcium-activated channel subfamily M regulatory beta subunit 1 2 6
MIRT515090 FAM120AOS family with sequence similarity 120A opposite strand 2 2
MIRT516113 OARD1 O-acyl-ADP-ribose deacylase 1 2 8
MIRT516657 PIGP phosphatidylinositol glycan anchor biosynthesis class P 2 2
MIRT516892 PLEKHS1 pleckstrin homology domain containing S1 2 2
MIRT517966 ZMIZ2 zinc finger MIZ-type containing 2 2 4
MIRT519492 PNPLA3 patatin like phospholipase domain containing 3 2 2
MIRT519799 ZNF226 zinc finger protein 226 2 2
MIRT524309 CTC1 CST telomere replication complex component 1 2 8
MIRT524425 CNKSR3 CNKSR family member 3 2 2
MIRT525927 KIAA0391 KIAA0391 2 2
MIRT528022 ACOT9 acyl-CoA thioesterase 9 2 2
MIRT528227 METTL8 methyltransferase like 8 2 2
MIRT528686 CEP57L1 centrosomal protein 57 like 1 2 2
MIRT528774 CD1D CD1d molecule 2 2
MIRT529935 P2RX7 purinergic receptor P2X 7 2 2
MIRT530642 PPIC peptidylprolyl isomerase C 2 4
MIRT530683 CHRNB1 cholinergic receptor nicotinic beta 1 subunit 2 4
MIRT531922 SLC4A1 solute carrier family 4 member 1 (Diego blood group) 2 2
MIRT532181 SEC14L5 SEC14 like lipid binding 5 2 4
MIRT534996 PRR11 proline rich 11 2 6
MIRT535452 PDCL phosducin like 2 4
MIRT544682 AP1S1 adaptor related protein complex 1 sigma 1 subunit 2 2
MIRT553757 TARBP2 TARBP2, RISC loading complex RNA binding subunit 2 4
MIRT560724 ZNF749 zinc finger protein 749 2 2
MIRT561518 SPTY2D1 SPT2 chromatin protein domain containing 1 2 2
MIRT561578 SLC30A1 solute carrier family 30 member 1 2 2
MIRT562483 CHORDC1 cysteine and histidine rich domain containing 1 2 2
MIRT565039 VAV2 vav guanine nucleotide exchange factor 2 2 2
MIRT565348 TMED4 transmembrane p24 trafficking protein 4 2 2
MIRT567104 KANSL1 KAT8 regulatory NSL complex subunit 1 2 2
MIRT568879 LY6H lymphocyte antigen 6 family member H 2 2
MIRT569141 NAP1L4 nucleosome assembly protein 1 like 4 2 2
MIRT569199 LRRC3C leucine rich repeat containing 3C 2 2
MIRT573559 TMEM120B transmembrane protein 120B 2 2
MIRT575931 Mrrf mitochondrial ribosome recycling factor 2 6
MIRT607035 MRRF mitochondrial ribosome recycling factor 2 9
MIRT607194 SPRY4 sprouty RTK signaling antagonist 4 2 2
MIRT609682 TMEM213 transmembrane protein 213 2 2
MIRT611227 ZNF274 zinc finger protein 274 2 2
MIRT611370 PLXDC1 plexin domain containing 1 2 4
MIRT611640 SCRG1 stimulator of chondrogenesis 1 2 2
MIRT613011 GABRB1 gamma-aminobutyric acid type A receptor beta1 subunit 2 2
MIRT613532 GTSE1 G2 and S-phase expressed 1 2 2
MIRT614459 REL REL proto-oncogene, NF-kB subunit 2 2
MIRT616492 CD300E CD300e molecule 2 2
MIRT617288 GTF2H3 general transcription factor IIH subunit 3 2 2
MIRT618356 CDKL1 cyclin dependent kinase like 1 2 2
MIRT619529 ZNF74 zinc finger protein 74 2 2
MIRT619990 ZSCAN22 zinc finger and SCAN domain containing 22 2 2
MIRT621286 ATP5E ATP synthase, H+ transporting, mitochondrial F1 complex, epsilon subunit 2 2
MIRT621482 GPKOW G-patch domain and KOW motifs 2 2
MIRT625456 RANGAP1 Ran GTPase activating protein 1 2 2
MIRT626757 NDUFA9 NADH:ubiquinone oxidoreductase subunit A9 2 2
MIRT629138 CTCFL CCCTC-binding factor like 2 2
MIRT630092 DCAF10 DDB1 and CUL4 associated factor 10 2 2
MIRT633501 RNF14 ring finger protein 14 2 2
MIRT633604 APCDD1 APC down-regulated 1 2 2
MIRT633772 F2 coagulation factor II, thrombin 2 2
MIRT635605 ADAT1 adenosine deaminase, tRNA specific 1 2 2
MIRT637422 EPB41L3 erythrocyte membrane protein band 4.1 like 3 2 2
MIRT637822 PLA2G7 phospholipase A2 group VII 2 2
MIRT637978 RRP36 ribosomal RNA processing 36 2 2
MIRT638385 RABL3 RAB, member of RAS oncogene family like 3 2 2
MIRT638547 KIAA1549 KIAA1549 2 2
MIRT642019 NCKIPSD NCK interacting protein with SH3 domain 2 2
MIRT643342 MICA MHC class I polypeptide-related sequence A 2 2
MIRT644281 LRRC57 leucine rich repeat containing 57 2 2
MIRT646818 COX19 COX19, cytochrome c oxidase assembly factor 2 2
MIRT646839 TLDC1 TBC/LysM-associated domain containing 1 2 2
MIRT646976 CYP2W1 cytochrome P450 family 2 subfamily W member 1 2 2
MIRT647735 CXCR2 C-X-C motif chemokine receptor 2 2 2
MIRT648598 ZYG11B zyg-11 family member B, cell cycle regulator 2 2
MIRT649843 LIPG lipase G, endothelial type 2 2
MIRT650031 VHL von Hippel-Lindau tumor suppressor 2 2
MIRT652082 TSPAN14 tetraspanin 14 2 2
MIRT652103 TRUB2 TruB pseudouridine synthase family member 2 2 2
MIRT652902 SYNPO2L synaptopodin 2 like 2 2
MIRT653549 SLC38A7 solute carrier family 38 member 7 2 2
MIRT653981 SEMA6B semaphorin 6B 2 2
MIRT654287 RCAN1 regulator of calcineurin 1 2 2
MIRT658372 FAM63B MINDY lysine 48 deubiquitinase 2 2 2
MIRT660321 BDP1 B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB 2 2
MIRT663063 LRIF1 ligand dependent nuclear receptor interacting factor 1 2 2
MIRT663269 ATP1A2 ATPase Na+/K+ transporting subunit alpha 2 2 2
MIRT664076 ZNF417 zinc finger protein 417 2 2
MIRT664193 MYOZ2 myozenin 2 2 2
MIRT664512 POLR3K RNA polymerase III subunit K 2 2
MIRT667025 PDF peptide deformylase, mitochondrial 2 2
MIRT669621 ACSL6 acyl-CoA synthetase long chain family member 6 2 2
MIRT670530 MLLT6 MLLT6, PHD finger containing 2 2
MIRT673050 SGPL1 sphingosine-1-phosphate lyase 1 2 2
MIRT683339 ZNF581 zinc finger protein 581 2 2
MIRT689264 WDR83OS WD repeat domain 83 opposite strand 2 2
MIRT690902 TOP2A DNA topoisomerase II alpha 2 2
MIRT699196 SLX4IP SLX4 interacting protein 2 2
MIRT702223 LONRF3 LON peptidase N-terminal domain and ring finger 3 2 2
MIRT707053 TRPV2 transient receptor potential cation channel subfamily V member 2 2 2
MIRT707080 MED29 mediator complex subunit 29 2 2
MIRT712347 NLN neurolysin 2 2
MIRT714715 KIT KIT proto-oncogene receptor tyrosine kinase 2 2
MIRT715963 CES4A carboxylesterase 4A 2 2
MIRT718224 DEFB105B defensin beta 105B 2 2
MIRT718244 DEFB105A defensin beta 105A 2 2
MIRT721960 GCK glucokinase 2 2
MIRT723098 SERINC3 serine incorporator 3 2 2
MIRT725207 PTPRT protein tyrosine phosphatase, receptor type T 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-4524b Tripterygium wilfordii Hook F resistant tissue
hsa-miR-4524b-3p Tamoxifen 2733525 NSC180973 approved sensitive cell line (LCC2)

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