miRTarBase - #MIRT461185


—
pre-miRNA Information
pre-miRNA hsa-mir-4753   
Genomic Coordinates chr1: 235190034 - 235190116
Description Homo sapiens miR-4753 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-4753-5p
Sequence 10| CAAGGCCAAAGGAAGAGAACAG |31
Evidence Experimental
Experiments Illumina
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs547986869 3 dbSNP
rs1007787337 7 dbSNP
rs1224263160 12 dbSNP
rs1256249071 13 dbSNP
rs1484015538 14 dbSNP
rs535678819 19 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol LTBP2   
Synonyms C14orf141, GLC3D, LTBP3, MSPKA, MSTP031, WMS3
Description latent transforming growth factor beta binding protein 2
Transcript NM_000428   
Expression
Putative miRNA Targets on LTBP2
3'UTR of LTBP2
(miRNA target sites are highlighted)		 
>LTBP2|NM_000428|3'UTR
   1 CAGTCAGGGGTCAGTGTGGCAACTACCTGGAAATGGCCTCCAGTCACAGGCAGGGGCCTTGAGGATGATTTCCTAGCTGG
  81 GAAGACACCGTGACATCAGGCCAGAGGTTTCCAATCAGCCTTGCCTGCTTTCATCTCTCCCAGCTTAGCCTCTGGCTGTA
 161 AGCTTCGGTCATTGCCTCCATGCCCTTGCTTGGCTCAAGCACCACCAATCGCTTTAATGCTTCAGCCACCGCATGAGGCC
 241 CTGTCCACCACCTTTCCTGGCCTTGCTATGGGATGCTTACCAAAGGATGGCCCTCATCCACCCTCCCAAGCTGTGCGAGC
 321 ATGCAAGGCCCCATGGCCTCACACTGCAGACACCCCTTTCCAGCCACAATCCACCATCATCCTGACGATCCCACAACTGG
 401 GACAGAGGCTACATCTGCCCTAGGGAGGTCCTTCAGAATCTGTGGAGCAAGAAAGGATTTGGGGAAGCTTGGGGACTGAC
 481 TCCAGAGCCCCCTCCTAAGAACCATCACCACCACTCAGCCAATCTGTTCTGGGCCCTGATTTTGCCACACCTCCATCCTG
 561 TAGCCCATTCTCTGACCCCAAGGAGTGGCAGAAGATCCCTTCACTCAGAGAAGCAAGGCTGATATTAGCTTGTTGAATGT
 641 AAGAGACACAAATGAAGAAGAACAAAGAGCCTGAGAAAGCAGCAAGAGGACATGATGAAAAATACGTGGAGTTGATGAGA
 721 AAGGGGAGCCAAGGCTTTATACGTCTAAAGAAAATATTCAGTAGCTGAATCCGCCCAGTGATAGCCTGTGGGCACCAGCA
 801 GCAAGGGCTGCCATGGGATACAGCACCCATCTACAAAGACCTCTATTACATAAACACTGCTTCTTACAGGAAACAAACCT
 881 CTTCTGGGATCTCCTTTTGTGAAAACCAGTTTGATGTGCTAAAAGTAAAAAGTCTATTTTCCAGTGTGGTCTTGTTCAGA
 961 AGCAGCCAGATTTCCAATGTTGTTTTTCCCCTCCACTCAGAAACCCCTGCCCTTTCCCTTCAGAAAACGATGGCAGGCAT
1041 TCCTCTGAGTTTACAAGCAGAGACTCACTCCAACCCAAACTAGCTGGGAGTTCAGAACCATGGTGGAATAAAGAAATGTG
1121 CATCTGGTCTCTTCTGTTGTTTTTATTTCATATCAGATTAAATTTCTTTACCATGTTGGCTAAGTCTAAATATTAGAGAT
1201 GAGGCTGTGCCTACTCCCTGGCCAGCTCTGCTGATAGCCTATGATGGGTTCCAATGGGAAATGACTCTTTACTATTAAAA
1281 GACAAGGAAAGCTCTGACTTCGTACTTCTCTGATGAATGGCAATGTAAATGAACAAGGCTCCATGTGACTGGAGCATGGA
1361 AGTGAATGCTACTTTCTTAATTTAATCTGCCCTGTCCTACCTGCTCCTCTGATTGTTAGCCATCACATAACTTATTGAAT
1441 GCTTGCCATGTGCCAGGCACTGTGCTGAGTGCCATACATACATTTCATTTAATTATCCAATAATCCTACTTACTATTGTT
1521 TATTCTCAATTTACAGGTGAGGAAACTGAGACATAGAAAGCTTAAATAATTTGCTCTAGGTCCCTATACTAATTGAGATG
1601 TTTTCAGCAGACAAAAATAAGTCACTCTTACGCATGTAAAAATATTCTTTCACTCATAATAAAAGAAATGCAACTTAAAA
1681 CCATACTGAGATCCTTTTTAAAACTGTCAGATTGGCAAAGATCAAAAAGCTTGTTAAGACTCCTAGCTGGCAAGCATGTG
1761 GGAAATAGGTACTCTCATAACAGCTGACAGAAGTACATATTGAAGAGGACAATATGGCAATGTCCTTCAAAATTATAAAA
1841 GCACTAACTCTTTGATCCAGTAGTTTCCACTTCTAGGAACTTAACCTTCAGATATATTTTCACCAGATATAAAATGACAT
1921 ACGTAAGAAGTTATTACTGCATCATTTGTAATAGCTAAAGATTAGAAACAATTAATTGCTATGGAACCCTTAAAAAAGGT
2001 GGCTCTAAATTCCTTAAGAAAGATATCCAAAACAAATTAAGGGGAAAAGGGAGGGTTGCATAACAGCATGTAACATAACA
2081 CTATTTGTCTAAAGAATGGGGAAAGAGAAGCGGTTGTCTGTTCACCTCATCCTTGCCACTCCGCCTTATACCTCACCATC
2161 GGAGAACTTACCATCCCCCAAATATATCCTGCTGGCACTACACCTTCGTAACTGCTGTTCCCACTGCCCCCACAACACTC
2241 CAATCTCCACCTTCCTGCCAACCTTGAGATATTGTATGCATATATACATATTTCCTTTGTTTAAAATACAAATAGCATAC
2321 TATGCATGCTGTTCTGCACTTTGCTTTTTTTTTATACTTGCAATTAGAGCTGCCTCATTTCATTTTACAGCTGTATACTA
2401 TTCCATTGAATGGATAAACCATAATTTATTTAATCAGTCCCTCACTGACAGACGTTTCCATTGTTTCCTGTCTTTTGCTA
2481 TAAATAATGCTGTAATGAATATTCTTGTGCATATTTCACATTAATTTATGGGATTACATCTGCAGGATAAATTCTTAGAA
2561 CCAATGGTGGTTTGTGGGGAGGGTGACAGGGTGGATAGGTACAGGATTGGGAGACTTTTCACTGTATCTCCTTTTGTATT
2641 TTTTTGAATTTTGTACCATATGTATCACCTATTCAAAAAAAATAAAATATTTTTAAATACAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' gaCAAGAGAAGGAA---ACCGGAAc 5'
            || | |  ||||   ||||||| 
Target 5' ctGTCCACCACCTTTCCTGGCCTTg 3'
 241 - 265 156.00 -18.90
2 
miRNA  3' gaCA-AGAGAAGG--AAACCGGAAc 5'
            || | |:||||  | |||:||| 
Target 5' aaGTCTATTTTCCAGTGTGGTCTTg 3'
 930 - 954 146.00 -16.90
3 
miRNA  3' gacaagaGAAGGA----AACCGGAac 5'
                 || |||     ||||||  
Target 5' gtggcaaCTACCTGGAAATGGCCTcc 3'
 16 - 41 125.00 -12.10
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
314264 11 ClinVar
314263 55 ClinVar
884477 119 ClinVar
314262 147 ClinVar
314261 167 ClinVar
314260 206 ClinVar
314259 229 ClinVar
314258 233 ClinVar
887441 312 ClinVar
887440 316 ClinVar
314257 373 ClinVar
887439 384 ClinVar
885345 397 ClinVar
885344 609 ClinVar
314256 638 ClinVar
885343 705 ClinVar
884415 742 ClinVar
314255 743 ClinVar
314254 824 ClinVar
884414 929 ClinVar
884413 945 ClinVar
887567 1005 ClinVar
887566 1029 ClinVar
314253 1170 ClinVar
314252 1180 ClinVar
314250 1302 ClinVar
314251 1302 ClinVar
887370 1393 ClinVar
886377 1427 ClinVar
886376 1481 ClinVar
314249 1521 ClinVar
314248 1631 ClinVar
314247 1743 ClinVar
886375 1776 ClinVar
884353 1777 ClinVar
314246 1818 ClinVar
884352 1873 ClinVar
314245 1957 ClinVar
314244 2026 ClinVar
887502 2044 ClinVar
887501 2112 ClinVar
887500 2153 ClinVar
887316 2236 ClinVar
314243 2266 ClinVar
314242 2353 ClinVar
887315 2363 ClinVar
886323 2419 ClinVar
886322 2463 ClinVar
886321 2569 ClinVar
886320 2684 ClinVar
COSN30452315 12 COSMIC
COSN30505624 19 COSMIC
COSN30490377 30 COSMIC
COSN31501295 41 COSMIC
COSN30469051 81 COSMIC
COSN30526397 89 COSMIC
COSN16001624 94 COSMIC
COSN28235835 677 COSMIC
COSN27596856 995 COSMIC
COSN31547698 1513 COSMIC
COSN30160469 1556 COSMIC
COSN30544123 1561 COSMIC
COSN31480523 1639 COSMIC
COSN31608484 1641 COSMIC
COSN31513720 1665 COSMIC
COSN6542950 2207 COSMIC
rs73296215 1957 GWAS
rs74384554 2684 GWAS
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1408905968 1 dbSNP
rs1372840869 2 dbSNP
rs1410785257 3 dbSNP
rs1375836700 5 dbSNP
rs1314499287 7 dbSNP
rs754048591 8 dbSNP
rs201969110 10 dbSNP
rs546442756 11 dbSNP
rs748049498 12 dbSNP
rs1365656319 16 dbSNP
rs760497578 19 dbSNP
rs1236260141 28 dbSNP
rs1285515491 41 dbSNP
rs773332497 43 dbSNP
rs761300537 45 dbSNP
rs368507186 52 dbSNP
rs185374765 55 dbSNP
rs1036512243 63 dbSNP
rs942118651 70 dbSNP
rs1403917813 75 dbSNP
rs1047655916 85 dbSNP
rs993325310 88 dbSNP
rs1468950020 89 dbSNP
rs559543287 90 dbSNP
rs1392208638 95 dbSNP
rs1038444827 100 dbSNP
rs1167635565 118 dbSNP
rs146119949 119 dbSNP
rs1241344759 120 dbSNP
rs986542449 123 dbSNP
rs931969771 126 dbSNP
rs1443152130 127 dbSNP
rs1044391124 128 dbSNP
rs1451217188 131 dbSNP
rs1203108003 134 dbSNP
rs886050753 147 dbSNP
rs1312480019 155 dbSNP
rs1349653087 158 dbSNP
rs1228672344 162 dbSNP
rs1286522843 166 dbSNP
rs574028105 167 dbSNP
rs1202148834 172 dbSNP
rs1279197015 181 dbSNP
rs557348037 184 dbSNP
rs112465641 185 dbSNP
rs192723743 206 dbSNP
rs779667099 207 dbSNP
rs1450397476 208 dbSNP
rs375641682 210 dbSNP
rs1192731284 211 dbSNP
rs527309087 215 dbSNP
rs975949301 221 dbSNP
rs141989493 229 dbSNP
rs117468792 230 dbSNP
rs1341846160 231 dbSNP
rs886050752 233 dbSNP
rs1405918903 235 dbSNP
rs558089942 246 dbSNP
rs1315765424 250 dbSNP
rs1399797248 253 dbSNP
rs879101185 256 dbSNP
rs1366721508 261 dbSNP
rs989092961 275 dbSNP
rs1294366902 276 dbSNP
rs1020103337 278 dbSNP
rs1324501114 290 dbSNP
rs1235085888 294 dbSNP
rs1275384991 299 dbSNP
rs1322645315 301 dbSNP
rs534807623 312 dbSNP
rs957387729 316 dbSNP
rs1465387256 317 dbSNP
rs978955987 322 dbSNP
rs1259854389 329 dbSNP
rs1435290174 333 dbSNP
rs1421998381 337 dbSNP
rs558492468 344 dbSNP
rs953978477 352 dbSNP
rs1429019670 355 dbSNP
rs372058379 355 dbSNP
rs921119094 359 dbSNP
rs964782617 363 dbSNP
rs1001615299 364 dbSNP
rs1161972225 365 dbSNP
rs971057427 367 dbSNP
rs886050751 373 dbSNP
rs1390252520 376 dbSNP
rs1453807191 382 dbSNP
rs1287949672 383 dbSNP
rs1239334697 386 dbSNP
rs1191261590 387 dbSNP
rs756741674 389 dbSNP
rs535631766 391 dbSNP
rs1008492792 396 dbSNP
rs954400565 400 dbSNP
rs1221665206 409 dbSNP
rs1290108023 415 dbSNP
rs569995132 439 dbSNP
rs1013866893 441 dbSNP
rs1026174745 455 dbSNP
rs1259189720 459 dbSNP
rs898064642 468 dbSNP
rs1489627314 469 dbSNP
rs1263612555 476 dbSNP
rs993854488 477 dbSNP
rs866352656 485 dbSNP
rs1489952094 494 dbSNP
rs1218531535 508 dbSNP
rs549805387 516 dbSNP
rs187561548 517 dbSNP
rs563935952 523 dbSNP
rs1419169651 526 dbSNP
rs1157656422 541 dbSNP
rs1037898027 548 dbSNP
rs1459175211 553 dbSNP
rs1303358013 559 dbSNP
rs1364778947 574 dbSNP
rs1402818623 577 dbSNP
rs1290981964 579 dbSNP
rs1228872763 583 dbSNP
rs1309789127 586 dbSNP
rs1036563708 591 dbSNP
rs1006356883 597 dbSNP
rs887869528 606 dbSNP
rs1323555762 609 dbSNP
rs753227965 611 dbSNP
rs1002059398 612 dbSNP
rs1267969910 617 dbSNP
rs931996354 624 dbSNP
rs1357772388 625 dbSNP
rs905925387 626 dbSNP
rs1044524060 633 dbSNP
rs1340759970 635 dbSNP
rs886050750 638 dbSNP
rs1299113627 639 dbSNP
rs1175976623 647 dbSNP
rs1402276614 653 dbSNP
rs1425010707 655 dbSNP
rs950020057 657 dbSNP
rs1384157146 663 dbSNP
rs917290434 670 dbSNP
rs923321550 688 dbSNP
rs1053371883 691 dbSNP
rs547341326 692 dbSNP
rs781592995 696 dbSNP
rs560071689 699 dbSNP
rs41307092 705 dbSNP
rs926234187 706 dbSNP
rs1380774423 707 dbSNP
rs1230880175 708 dbSNP
rs1274224738 712 dbSNP
rs979310301 712 dbSNP
rs1475173387 717 dbSNP
rs943567694 727 dbSNP
rs1195519937 728 dbSNP
rs1462276779 730 dbSNP
rs913148674 742 dbSNP
rs541978964 743 dbSNP
rs1190086328 755 dbSNP
rs1420010828 762 dbSNP
rs1427659428 765 dbSNP
rs1267971910 772 dbSNP
rs1168261726 777 dbSNP
rs1222216384 780 dbSNP
rs1470348023 784 dbSNP
rs1453316587 788 dbSNP
rs987210120 792 dbSNP
rs1213484701 797 dbSNP
rs142586523 805 dbSNP
rs529442225 806 dbSNP
rs61980864 807 dbSNP
rs574577021 815 dbSNP
rs7569 824 dbSNP
rs1343992263 844 dbSNP
rs1324965374 855 dbSNP
rs750693740 859 dbSNP
rs1262013261 865 dbSNP
rs115881853 866 dbSNP
rs1217535994 867 dbSNP
rs76333864 868 dbSNP
rs1474966751 889 dbSNP
rs1352132742 906 dbSNP
rs1184493134 912 dbSNP
rs544422625 917 dbSNP
rs1480757010 921 dbSNP
rs1175589944 929 dbSNP
rs1326856357 932 dbSNP
rs1016202568 936 dbSNP
rs374130664 945 dbSNP
rs905057670 947 dbSNP
rs1428880598 949 dbSNP
rs1295709945 951 dbSNP
rs993824202 968 dbSNP
rs962293711 969 dbSNP
rs1015152887 977 dbSNP
rs1006815090 980 dbSNP
rs1223482978 984 dbSNP
rs1281886368 986 dbSNP
rs1173060255 987 dbSNP
rs541743695 1005 dbSNP
rs1224907972 1010 dbSNP
rs1284528086 1013 dbSNP
rs1051015864 1025 dbSNP
rs1213195564 1026 dbSNP
rs183438163 1028 dbSNP
rs572909673 1033 dbSNP
rs1191574652 1051 dbSNP
rs1471209300 1068 dbSNP
rs1159286289 1070 dbSNP
rs1407328912 1086 dbSNP
rs1478932089 1109 dbSNP
rs1399221730 1110 dbSNP
rs1043337000 1113 dbSNP
rs1366616899 1120 dbSNP
rs901916734 1129 dbSNP
rs1301848708 1136 dbSNP
rs145355511 1139 dbSNP
rs1352795464 1160 dbSNP
rs886050749 1170 dbSNP
rs1279687794 1171 dbSNP
rs987177569 1172 dbSNP
rs1203151767 1174 dbSNP
rs535695688 1178 dbSNP
rs576929018 1180 dbSNP
rs1359919168 1188 dbSNP
rs1201378830 1190 dbSNP
rs919019373 1197 dbSNP
rs34676576 1209 dbSNP
rs1182403810 1230 dbSNP
rs1232410843 1231 dbSNP
rs935849895 1235 dbSNP
rs963102917 1236 dbSNP
rs778112867 1237 dbSNP
rs1424426492 1241 dbSNP
rs1162140643 1244 dbSNP
rs1016584219 1254 dbSNP
rs1411065383 1257 dbSNP
rs1328734556 1258 dbSNP
rs868710850 1262 dbSNP
rs556284173 1265 dbSNP
rs768532960 1270 dbSNP
rs980749268 1271 dbSNP
rs969208256 1283 dbSNP
rs1024776382 1290 dbSNP
rs1289381579 1298 dbSNP
rs1341169623 1299 dbSNP
rs971202468 1301 dbSNP
rs191692241 1302 dbSNP
rs540009806 1302 dbSNP
rs904550300 1306 dbSNP
rs558596992 1313 dbSNP
rs775199545 1318 dbSNP
rs961005039 1322 dbSNP
rs1401123203 1323 dbSNP
rs771886578 1324 dbSNP
rs1167871015 1331 dbSNP
rs1394899422 1338 dbSNP
rs1333517163 1341 dbSNP
rs1468379691 1346 dbSNP
rs1338196450 1352 dbSNP
rs1299014494 1353 dbSNP
rs943660469 1361 dbSNP
rs1451507468 1362 dbSNP
rs1176472763 1363 dbSNP
rs1328002835 1378 dbSNP
rs889367179 1401 dbSNP
rs1337443694 1403 dbSNP
rs534068941 1411 dbSNP
rs1051844164 1415 dbSNP
rs933502371 1416 dbSNP
rs187052141 1427 dbSNP
rs1202044807 1433 dbSNP
rs952383257 1434 dbSNP
rs778481508 1435 dbSNP
rs547110933 1449 dbSNP
rs1192841924 1458 dbSNP
rs908919518 1472 dbSNP
rs1481732529 1475 dbSNP
rs527271189 1481 dbSNP
rs778822852 1496 dbSNP
rs1468784584 1500 dbSNP
rs1181227953 1511 dbSNP
rs980437517 1513 dbSNP
rs996746157 1514 dbSNP
rs1482684533 1515 dbSNP
rs969260946 1515 dbSNP
rs565536636 1521 dbSNP
rs567860502 1521 dbSNP
rs1225319105 1524 dbSNP
rs1283806102 1526 dbSNP
rs1211196885 1533 dbSNP
rs901938394 1536 dbSNP
rs1322947041 1547 dbSNP
rs1314282189 1561 dbSNP
rs1018950704 1564 dbSNP
rs1010206177 1567 dbSNP
rs1262722916 1573 dbSNP
rs891772775 1576 dbSNP
rs1351759386 1579 dbSNP
rs560399527 1589 dbSNP
rs956549151 1593 dbSNP
rs1032159283 1599 dbSNP
rs998982803 1607 dbSNP
rs1054365266 1617 dbSNP
rs1268727817 1631 dbSNP
rs183119073 1631 dbSNP
rs773817321 1632 dbSNP
rs1044273316 1643 dbSNP
rs563731177 1646 dbSNP
rs1157602037 1647 dbSNP
rs1358423961 1653 dbSNP
rs1378312761 1667 dbSNP
rs1311472998 1669 dbSNP
rs1344730146 1705 dbSNP
rs748819133 1710 dbSNP
rs1309322227 1713 dbSNP
rs1317558423 1715 dbSNP
rs1007521109 1725 dbSNP
rs1259130498 1733 dbSNP
rs543965530 1742 dbSNP
rs781717691 1743 dbSNP
rs1223598710 1756 dbSNP
rs1291497989 1766 dbSNP
rs1179439984 1768 dbSNP
rs1490018993 1768 dbSNP
rs1378655630 1776 dbSNP
rs1419112516 1777 dbSNP
rs889335158 1780 dbSNP
rs1051992757 1787 dbSNP
rs1426326728 1793 dbSNP
rs1303624662 1794 dbSNP
rs1364722944 1798 dbSNP
rs917018488 1800 dbSNP
rs972454508 1802 dbSNP
rs997628900 1815 dbSNP
rs1052939 1818 dbSNP
rs1307352458 1844 dbSNP
rs1157885885 1850 dbSNP
rs1246967758 1867 dbSNP
rs1385344053 1867 dbSNP
rs752139439 1870 dbSNP
rs77847288 1873 dbSNP
rs867537188 1877 dbSNP
rs984185819 1881 dbSNP
rs568215347 1882 dbSNP
rs1029619699 1892 dbSNP
rs1480681841 1895 dbSNP
rs750625790 1909 dbSNP
rs1256303109 1915 dbSNP
rs974946001 1922 dbSNP
rs755969599 1923 dbSNP
rs541467389 1926 dbSNP
rs1172457560 1931 dbSNP
rs1354967073 1937 dbSNP
rs947720261 1945 dbSNP
rs917820749 1952 dbSNP
rs1408360456 1957 dbSNP
rs73296215 1957 dbSNP
rs1314583018 1958 dbSNP
rs1377461540 1964 dbSNP
rs374829064 1968 dbSNP
rs555938966 1969 dbSNP
rs1216635205 1978 dbSNP
rs960444892 1984 dbSNP
rs956736934 1988 dbSNP
rs1217324559 1998 dbSNP
rs1307492773 1998 dbSNP
rs923835884 2003 dbSNP
rs542354241 2006 dbSNP
rs1019003262 2020 dbSNP
rs753248465 2024 dbSNP
rs886050748 2026 dbSNP
rs891867031 2031 dbSNP
rs1033047042 2033 dbSNP
rs1188118698 2036 dbSNP
rs1419946194 2038 dbSNP
rs1427898419 2041 dbSNP
rs73296214 2044 dbSNP
rs1007490050 2055 dbSNP
rs1313615819 2056 dbSNP
rs1470317074 2061 dbSNP
rs1397992207 2064 dbSNP
rs1357577308 2065 dbSNP
rs1360149109 2074 dbSNP
rs905781505 2075 dbSNP
rs1289880742 2081 dbSNP
rs1361676723 2085 dbSNP
rs1398743794 2088 dbSNP
rs1297281068 2097 dbSNP
rs1044679202 2111 dbSNP
rs949885665 2112 dbSNP
rs1301188148 2120 dbSNP
rs895677296 2123 dbSNP
rs1368531345 2142 dbSNP
rs1310132812 2149 dbSNP
rs113879332 2153 dbSNP
rs539604468 2156 dbSNP
rs1422517644 2158 dbSNP
rs939786766 2160 dbSNP
rs909631566 2161 dbSNP
rs1488810380 2167 dbSNP
rs983806749 2170 dbSNP
rs932275887 2171 dbSNP
rs898076518 2172 dbSNP
rs1052942 2175 dbSNP
rs868460877 2177 dbSNP
rs1402711314 2181 dbSNP
rs1265845863 2183 dbSNP
rs1160069014 2196 dbSNP
rs1345008053 2207 dbSNP
rs922221673 2208 dbSNP
rs1305489419 2212 dbSNP
rs975376297 2220 dbSNP
rs1346765093 2227 dbSNP
rs966247712 2231 dbSNP
rs753803515 2236 dbSNP
rs1273781546 2249 dbSNP
rs1036498641 2263 dbSNP
rs886050747 2266 dbSNP
rs1225146035 2271 dbSNP
rs1284460467 2272 dbSNP
rs1006815021 2286 dbSNP
rs1214097104 2288 dbSNP
rs1293670032 2292 dbSNP
rs887511960 2301 dbSNP
rs1198055869 2303 dbSNP
rs1247088489 2313 dbSNP
rs1471179222 2315 dbSNP
rs1178006583 2324 dbSNP
rs1316248434 2326 dbSNP
rs1044861211 2333 dbSNP
rs1277826035 2339 dbSNP
rs947688846 2342 dbSNP
rs1322101005 2345 dbSNP
rs1342104335 2345 dbSNP
rs1279775983 2349 dbSNP
rs912089489 2352 dbSNP
rs552983028 2353 dbSNP
rs1056391821 2354 dbSNP
rs896187750 2354 dbSNP
rs935221196 2354 dbSNP
rs956161692 2359 dbSNP
rs1359850909 2360 dbSNP
rs1209203209 2361 dbSNP
rs190461277 2363 dbSNP
rs1439633468 2367 dbSNP
rs1294736996 2371 dbSNP
rs1460047076 2374 dbSNP
rs1398983058 2384 dbSNP
rs979258571 2386 dbSNP
rs576018096 2393 dbSNP
rs1438116399 2398 dbSNP
rs946558277 2399 dbSNP
rs1386280631 2401 dbSNP
rs1472645552 2402 dbSNP
rs764238545 2406 dbSNP
rs533581873 2408 dbSNP
rs1411013596 2418 dbSNP
rs1394481702 2429 dbSNP
rs1329015498 2442 dbSNP
rs1478637653 2445 dbSNP
rs1398897900 2451 dbSNP
rs79540518 2453 dbSNP
rs1030252251 2454 dbSNP
rs1383290910 2462 dbSNP
rs10141546 2463 dbSNP
rs1282203836 2470 dbSNP
rs1341454847 2488 dbSNP
rs1014210177 2492 dbSNP
rs1456467689 2497 dbSNP
rs1205832371 2499 dbSNP
rs1433044843 2508 dbSNP
rs895728197 2511 dbSNP
rs531324462 2514 dbSNP
rs1185953735 2517 dbSNP
rs775430648 2525 dbSNP
rs1006371975 2536 dbSNP
rs1170557740 2546 dbSNP
rs1422334625 2551 dbSNP
rs1463565275 2556 dbSNP
rs1178165552 2564 dbSNP
rs1036906772 2566 dbSNP
rs531824728 2569 dbSNP
rs1456478554 2577 dbSNP
rs1395072807 2583 dbSNP
rs1332000221 2588 dbSNP
rs759369859 2593 dbSNP
rs1327945550 2594 dbSNP
rs1431431496 2598 dbSNP
rs1277430142 2600 dbSNP
rs1316158353 2601 dbSNP
rs1023380344 2603 dbSNP
rs1263827527 2604 dbSNP
rs888211313 2607 dbSNP
rs1257546490 2621 dbSNP
rs1048590123 2624 dbSNP
rs1198926378 2626 dbSNP
rs1199499511 2626 dbSNP
rs896238620 2627 dbSNP
rs1447903437 2630 dbSNP
rs187434507 2638 dbSNP
rs1193607105 2646 dbSNP
rs774052044 2646 dbSNP
rs1320289903 2666 dbSNP
rs1481700978 2668 dbSNP
rs1201026672 2672 dbSNP
rs1377673308 2683 dbSNP
rs570997244 2683 dbSNP
rs1170402168 2684 dbSNP
rs74384554 2684 dbSNP
rs902403589 2690 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions TZM-bl
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM1462574. RNA binding protein: AGO2. Condition:TZM-bl ami BaL ...

- Whisnant AW; Bogerd HP; Flores O; Ho P; et al., 2013, mBio.

Article - Whisnant AW; Bogerd HP; Flores O; Ho P; et al.
- mBio, 2013
UNLABELLED: The question of how HIV-1 interfaces with cellular microRNA (miRNA) biogenesis and effector mechanisms has been highly controversial. Here, we first used deep sequencing of small RNAs present in two different infected cell lines (TZM-bl and C8166) and two types of primary human cells (CD4(+) peripheral blood mononuclear cells [PBMCs] and macrophages) to unequivocally demonstrate that HIV-1 does not encode any viral miRNAs. Perhaps surprisingly, we also observed that infection of T cells by HIV-1 has only a modest effect on the expression of cellular miRNAs at early times after infection. Comprehensive analysis of miRNA binding to the HIV-1 genome using the photoactivatable ribonucleoside-induced cross-linking and immunoprecipitation (PAR-CLIP) technique revealed several binding sites for cellular miRNAs, a subset of which were shown to be capable of mediating miRNA-mediated repression of gene expression. However, the main finding from this analysis is that HIV-1 transcripts are largely refractory to miRNA binding, most probably due to extensive viral RNA secondary structure. Together, these data demonstrate that HIV-1 neither encodes viral miRNAs nor strongly influences cellular miRNA expression, at least early after infection, and imply that HIV-1 transcripts have evolved to avoid inhibition by preexisting cellular miRNAs by adopting extensive RNA secondary structures that occlude most potential miRNA binding sites. IMPORTANCE: MicroRNAs (miRNAs) are a ubiquitous class of small regulatory RNAs that serve as posttranscriptional regulators of gene expression. Previous work has suggested that HIV-1 might subvert the function of the cellular miRNA machinery by expressing viral miRNAs or by dramatically altering the level of cellular miRNA expression. Using very sensitive approaches, we now demonstrate that neither of these ideas is in fact correct. Moreover, HIV-1 transcripts appear to largely avoid regulation by cellular miRNAs by adopting an extensive RNA secondary structure that occludes the ability of cellular miRNAs to interact with viral mRNAs. Together, these data suggest that HIV-1, rather than seeking to control miRNA function in infected cells, has instead evolved a mechanism to become largely invisible to cellular miRNA effector mechanisms.
LinkOut: [PMID: 23592263]
Experimental Support 2 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HCT116
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in ERX177603. RNA binding protein: AGO2. Condition:p53_D_AGO_CLIP_2_5 PAR-CLIP data was present in ERX177619. RNA binding protein: AGO2. Condition:p53_D_AGO_CLIP_3_9 ...

- Krell J; Stebbing J; Carissimi C; Dabrowska et al., 2016, Genome research.

Article - Krell J; Stebbing J; Carissimi C; Dabrowska et al.
- Genome research, 2016
DNA damage activates TP53-regulated surveillance mechanisms that are crucial in suppressing tumorigenesis. TP53 orchestrates these responses directly by transcriptionally modulating genes, including microRNAs (miRNAs), and by regulating miRNA biogenesis through interacting with the DROSHA complex. However, whether the association between miRNAs and AGO2 is regulated following DNA damage is not yet known. Here, we show that, following DNA damage, TP53 interacts with AGO2 to induce or reduce AGO2's association of a subset of miRNAs, including multiple let-7 family members. Furthermore, we show that specific mutations in TP53 decrease rather than increase the association of let-7 family miRNAs, reducing their activity without preventing TP53 from interacting with AGO2. This is consistent with the oncogenic properties of these mutants. Using AGO2 RIP-seq and PAR-CLIP-seq, we show that the DNA damage-induced increase in binding of let-7 family members to the RISC complex is functional. We unambiguously determine the global miRNA-mRNA interaction networks involved in the DNA damage response, validating them through the identification of miRNA-target chimeras formed by endogenous ligation reactions. We find that the target complementary region of the let-7 seed tends to have highly fixed positions and more variable ones. Additionally, we observe that miRNAs, whose cellular abundance or differential association with AGO2 is regulated by TP53, are involved in an intricate network of regulatory feedback and feedforward circuits. TP53-mediated regulation of AGO2-miRNA interaction represents a new mechanism of miRNA regulation in carcinogenesis.
LinkOut: [PMID: 26701625]
CLIP-seq Support 1 for dataset GSM1462574
Method / RBP PAR-CLIP / AGO2
Cell line / Condition TZM-bl / TZM-bl ami BaL
Location of target site ENST00000261978.4 | 3UTR | UCCACCACCUUUCCUGG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23592263 / GSE59944
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
94 hsa-miR-4753-5p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT064916 ZBTB18 zinc finger and BTB domain containing 18 2 2
MIRT161166 SLC25A36 solute carrier family 25 member 36 2 2
MIRT285542 CDT1 chromatin licensing and DNA replication factor 1 2 2
MIRT308266 LRIG1 leucine rich repeats and immunoglobulin like domains 1 2 2
MIRT311425 LMNB1 lamin B1 2 2
MIRT373989 PEBP1 phosphatidylethanolamine binding protein 1 2 4
MIRT383141 CRY2 cryptochrome circadian clock 2 2 2
MIRT405243 ADIPOR2 adiponectin receptor 2 2 2
MIRT441620 ROCK1 Rho associated coiled-coil containing protein kinase 1 2 6
MIRT441789 SRPK1 SRSF protein kinase 1 2 2
MIRT441804 NOC3L NOC3 like DNA replication regulator 2 2
MIRT441832 ALG14 ALG14, UDP-N-acetylglucosaminyltransferase subunit 2 2
MIRT442005 NDUFV3 NADH:ubiquinone oxidoreductase subunit V3 2 2
MIRT442411 LIMD1 LIM domains containing 1 2 2
MIRT442708 UBE4B ubiquitination factor E4B 2 2
MIRT442714 TNRC6B trinucleotide repeat containing 6B 2 2
MIRT442738 SERINC5 serine incorporator 5 2 2
MIRT442793 CEP170 centrosomal protein 170 2 2
MIRT442984 ZNF736 zinc finger protein 736 2 2
MIRT443055 THRB thyroid hormone receptor beta 2 2
MIRT443288 ZC3H12A zinc finger CCCH-type containing 12A 2 2
MIRT443325 SLC35G1 solute carrier family 35 member G1 2 2
MIRT443331 OCRL OCRL, inositol polyphosphate-5-phosphatase 2 2
MIRT443593 ZNF439 zinc finger protein 439 2 4
MIRT443696 KCNN3 potassium calcium-activated channel subfamily N member 3 2 2
MIRT443748 ELL2 elongation factor for RNA polymerase II 2 2 2
MIRT443866 HDLBP high density lipoprotein binding protein 2 2
MIRT461185 LTBP2 latent transforming growth factor beta binding protein 2 2 2
MIRT464074 WAC WW domain containing adaptor with coiled-coil 2 2
MIRT468738 SDC4 syndecan 4 2 2
MIRT470540 COASY Coenzyme A synthase 2 2
MIRT476458 GBA2 glucosylceramidase beta 2 2 2
MIRT479470 CDK6 cyclin dependent kinase 6 2 2
MIRT486351 TACC2 transforming acidic coiled-coil containing protein 2 2 8
MIRT495126 CXorf67 chromosome X open reading frame 67 2 2
MIRT495166 CNGA2 cyclic nucleotide gated channel alpha 2 2 4
MIRT495432 ATG7 autophagy related 7 2 2
MIRT495922 FBXO41 F-box protein 41 2 2
MIRT496572 DGCR6L DiGeorge syndrome critical region gene 6 like 2 2
MIRT498277 POFUT1 protein O-fucosyltransferase 1 2 2
MIRT498431 DDX39A DExD-box helicase 39A 2 2
MIRT530149 HADHB hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), beta subunit 2 2
MIRT530313 TNFRSF10D TNF receptor superfamily member 10d 2 2
MIRT530880 TRUB1 TruB pseudouridine synthase family member 1 2 4
MIRT531177 ZNF626 zinc finger protein 626 2 2
MIRT533395 TYRP1 tyrosinase related protein 1 2 2
MIRT533709 TMEM64 transmembrane protein 64 2 2
MIRT533954 TAF1D TATA-box binding protein associated factor, RNA polymerase I subunit D 2 2
MIRT535616 NSD1 nuclear receptor binding SET domain protein 1 2 2
MIRT539472 ADARB2 adenosine deaminase, RNA specific B2 (inactive) 2 2
MIRT542878 NR6A1 nuclear receptor subfamily 6 group A member 1 2 2
MIRT559077 C19orf47 chromosome 19 open reading frame 47 2 2
MIRT559465 ARPP19 cAMP regulated phosphoprotein 19 2 2
MIRT561233 ZNF772 zinc finger protein 772 2 2
MIRT563477 POLE3 DNA polymerase epsilon 3, accessory subunit 2 2
MIRT563995 SLFN11 schlafen family member 11 2 2
MIRT564222 SDE2 SDE2 telomere maintenance homolog 2 2
MIRT566017 RHOA ras homolog family member A 2 2
MIRT566028 RFX1 regulatory factor X1 2 2
MIRT566591 NUFIP2 NUFIP2, FMR1 interacting protein 2 2 2
MIRT567874 CTDSP1 CTD small phosphatase 1 2 2
MIRT568552 AKT2 AKT serine/threonine kinase 2 2 2
MIRT569357 EFHC1 EF-hand domain containing 1 2 2
MIRT569973 DNAAF2 dynein axonemal assembly factor 2 2 2
MIRT614423 ZNF440 zinc finger protein 440 2 2
MIRT628831 SLC25A34 solute carrier family 25 member 34 2 2
MIRT630142 ZFYVE9 zinc finger FYVE-type containing 9 2 2
MIRT634479 PAFAH1B2 platelet activating factor acetylhydrolase 1b catalytic subunit 2 2 2
MIRT634498 OR7D2 olfactory receptor family 7 subfamily D member 2 2 2
MIRT637394 R3HDM2 R3H domain containing 2 2 2
MIRT641840 TCF7L2 transcription factor 7 like 2 2 2
MIRT644397 CDKL1 cyclin dependent kinase like 1 2 2
MIRT644888 C2orf50 chromosome 2 open reading frame 50 2 2
MIRT647124 ZNF446 zinc finger protein 446 2 2
MIRT647420 SSTR3 somatostatin receptor 3 2 2
MIRT650297 PYCARD PYD and CARD domain containing 2 2
MIRT655488 PAK3 p21 (RAC1) activated kinase 3 2 2
MIRT658185 FBXO9 F-box protein 9 2 2
MIRT660931 ADAM19 ADAM metallopeptidase domain 19 2 2
MIRT665317 ZBTB3 zinc finger and BTB domain containing 3 2 2
MIRT670350 C1orf106 chromosome 1 open reading frame 106 2 4
MIRT670823 NICN1 nicolin 1 2 2
MIRT671825 TRPM6 transient receptor potential cation channel subfamily M member 6 2 2
MIRT672732 NETO2 neuropilin and tolloid like 2 2 2
MIRT674841 GLRX2 glutaredoxin 2 2 2
MIRT675930 CYP51A1 cytochrome P450 family 51 subfamily A member 1 2 2
MIRT686786 AZF1 azoospermia factor 1 2 2
MIRT697723 USP8 ubiquitin specific peptidase 8 2 2
MIRT702357 KLHL26 kelch like family member 26 2 2
MIRT704361 DBR1 debranching RNA lariats 1 2 2
MIRT709242 RANGAP1 Ran GTPase activating protein 1 2 2
MIRT714433 SNED1 sushi, nidogen and EGF like domains 1 2 2
MIRT717000 ARL6IP4 ADP ribosylation factor like GTPase 6 interacting protein 4 2 2
MIRT720875 ADCY5 adenylate cyclase 5 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-4753 Cisplatin 5460033 NSC119875 approved sensitive cell line (A2780)
hsa-miR-4753-5p Gefitinib 123631 NSC715055 approved resistant cell line (HCC827)
hsa-miR-4753-5p Osimertinib 71496458 NSC779217 approved resistant cell line (HCC827)
hsa-miR-4753-5p Osimertinib 71496458 NSC779217 approved sensitive cell line (H1975)
hsa-miR-4753-5p Cisplatin 5460033 NSC119875 approved resistant cell line (A2780)
hsa-miR-4753-5p Platinum 23939 resistant tissue
hsa-miR-4753-5p Gemcitabine 60750 NSC613327 approved resistant cell line (PANC-1) (1500 ng/ml)
hsa-miR-4753-5p Gemcitabine 60750 NSC613327 approved resistant cell line (PANC-1) (100 ng/ml)
hsa-miR-4753-5p Gemcitabine 60750 NSC613327 approved resistant cell line (Panc1-GR4)

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