miRTarBase - #MIRT461274


—
pre-miRNA Information
pre-miRNA hsa-mir-4651   
Genomic Coordinates chr7: 75915197 - 75915269
Description Homo sapiens miR-4651 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-4651
Sequence 10| CGGGGUGGGUGAGGUCGGGC |29
Evidence Experimental
Experiments Illumina
DRVs in miRNA
Mutant ID Mutant Position Mutant Source
COSN30595227 5 COSMIC
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1458858872 1 dbSNP
rs887877274 2 dbSNP
rs559953168 4 dbSNP
rs1332072774 12 dbSNP
rs868980356 12 dbSNP
rs1291879524 14 dbSNP
rs1228835859 19 dbSNP
rs1349605668 19 dbSNP
rs1277626081 20 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol COX10   
Synonyms -
Description COX10, heme A:farnesyltransferase cytochrome c oxidase assembly factor
Transcript NM_001303   
Expression
Putative miRNA Targets on COX10
3'UTR of COX10
(miRNA target sites are highlighted)		 
>COX10|NM_001303|3'UTR
   1 GAGCACTGGGACGCCCACCGCCCCTTTCCCTCCGCTGCCAGGCGAGCATGTTGTGGTAATTCTGGAACACAAGAAGAGAA
  81 ATTGCTGGGTTTAGAACAAGATTATAAACGAATTCGGTGCTCAGTGATCACTTGACAGTTTTTTTTTTTTTTAAATATTA
 161 CCCAAAATGCTCCCCAAATAAGAAATGCATCAGCTCAGTCAGTGAATACAAAAAAGGAATTATTTTTCCCTTTGAGGGTC
 241 TTTATACATCTCTCCTCCAACCCCACCCTCTATTCTGTTTCTTCCTCCTCACATGGGGGTACACATACACAGCTTCCTCT
 321 TTTGGTTCCATCCTTACCACCACACCACACGCACACTCCACATGCCCAGCAGAGTGGCACTTGGTGGCCAGAAAGTGTGA
 401 GCCTCATGATCTGCTGTCTGTAGTTCTGTGAGCTCAGGTCCCTCAAAGGCCTCGGAGCACCCCCTTCCTGGTGACTGAGC
 481 CAGGGCCTGCATTTTTGGTTTTCCCCACCCCACACATTCTCAACCATAGTCCTTCTAACAATACCAATAGCTAGGACCCG
 561 GCTGCTGTGCACTGGGACTGGGGATTCCACATGTTTGCCTTGGGAGTCTCAAGCTGGACTGCCAGCCCCTGTCCTCCCTT
 641 CACCCCCATTGCGTATGAGCATTTCAGAACTCCAAGGAGTCACAGGCATCTTTATAGTTCACGTTAACATATAGACACTG
 721 TTGGAAGCAGTTCCTTCTAAAAGGGTAGCCCTGGACTTAATACCAGCCGGATACCTCTGGCCCCCACCCCATTACTGTAC
 801 CTCTGGAGTCACTACTGTGGGTCGCCACTCCTCTGCTACACAGCACGGCTTTTTCAAGGCTGTATTGAGAAGGGAAGTTA
 881 GGAAGAAGGGTGTGCTGGGCTAACCAGCCCACAGAGCTCACATTCCTGTCCCTTGGGTGAAAAATACATGTCCATCCTGA
 961 TATCTCCTGAATTCAGAAATTAGCCTCCACATGTGCAATGGCTTTAAGAGCCAGAAGCAGGGTTCTGGGAATTTTGCAAG
1041 TTATCCTGTGGCCAGGTGTGGTCTCGGTTACCAAATACGGTTACCTGCAGCTTTTTAGTCCTTTGTGCTCCCACGGGTCT
1121 GCAGAGTCCCATCTGCCCAAAGGTCTTGAAGCTTGACAGGATGTTTTCATTACTCAGTCTCCCAGGGCACTGCTGGTCCG
1201 TAGGGATTCATTGGTCGGGGTGGGAGAGTTAAACAACATTTAAACAGAGTTCTCTCAAAAATGTCTAAAGGGATTGTAGG
1281 TAGATAACATCCAATCACTGTTTGCACTTATCTGAAATCTTCCCTCTTGGCTGCCCCCAGGTATTTACTGTGGAGAACAT
1361 TGCATAGGAATGTCTGGAAAAAGCCTCTACAACTTGTTACAGCCTTCACATTTGTACAATTCATTGATTCTCTTTTCCTT
1441 CCACAATAAAATGGTATACAAGAACAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' cgGGCUGGAGUGGGUGGGGc 5'
            ::|:::|: |||||||| 
Target 5' ttTTGGTTTTCCCCACCCCa 3'
 493 - 512 158.00 -23.20
2 
miRNA  3' cgGGC---UGGA----GUGGGUGGGGc 5'
            |||   ||||    | |||||||| 
Target 5' agCCGGATACCTCTGGCCCCCACCCCa 3'
 765 - 791 156.00 -27.70
3 
miRNA  3' cgGGCUGGAGUG-GGUGGGGc 5'
            |:| |||| | :|||||| 
Target 5' ccCTGTCCTCCCTTCACCCCc 3'
 627 - 647 146.00 -24.30
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
321818 14 ClinVar
321819 139 ClinVar
321820 139 ClinVar
890315 145 ClinVar
321821 153 ClinVar
321822 298 ClinVar
890316 306 ClinVar
321823 323 ClinVar
321824 372 ClinVar
321825 409 ClinVar
321826 439 ClinVar
892116 486 ClinVar
321827 536 ClinVar
892117 540 ClinVar
321828 564 ClinVar
321829 591 ClinVar
321830 629 ClinVar
888669 629 ClinVar
321831 647 ClinVar
321832 647 ClinVar
888670 654 ClinVar
890373 721 ClinVar
321833 740 ClinVar
321834 758 ClinVar
321835 824 ClinVar
321836 831 ClinVar
890933 860 ClinVar
890934 895 ClinVar
890935 905 ClinVar
321837 975 ClinVar
892165 1003 ClinVar
892166 1033 ClinVar
321838 1077 ClinVar
321839 1079 ClinVar
888723 1080 ClinVar
321840 1102 ClinVar
888724 1149 ClinVar
888725 1268 ClinVar
321841 1325 ClinVar
321842 1368 ClinVar
890428 1384 ClinVar
321843 1386 ClinVar
321844 1459 ClinVar
COSN30522231 7 COSMIC
COSN6099339 18 COSMIC
COSN26971634 20 COSMIC
COSN18740699 36 COSMIC
COSN30699786 45 COSMIC
COSN20113579 152 COSMIC
COSN6414828 152 COSMIC
COSN20113577 153 COSMIC
COSN20113578 153 COSMIC
COSN6414829 153 COSMIC
COSN20079090 154 COSMIC
COSN9655908 279 COSMIC
COSN9655909 343 COSMIC
COSN32058036 372 COSMIC
COSN31644993 571 COSMIC
COSN25043377 744 COSMIC
COSN32058037 758 COSMIC
COSN20113580 834 COSMIC
COSN513234 900 COSMIC
COSN23577342 940 COSMIC
COSN30019483 1300 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1292225268 1 dbSNP
rs766853368 3 dbSNP
rs751928758 6 dbSNP
rs760139431 7 dbSNP
rs1338818407 8 dbSNP
rs1391526058 12 dbSNP
rs753213748 13 dbSNP
rs371047487 14 dbSNP
rs1401740459 17 dbSNP
rs777899213 20 dbSNP
rs375602415 21 dbSNP
rs1157495493 26 dbSNP
rs971466945 30 dbSNP
rs887469940 34 dbSNP
rs757407927 35 dbSNP
rs1332474236 37 dbSNP
rs1322588618 40 dbSNP
rs1408904779 43 dbSNP
rs778711767 44 dbSNP
rs373074821 45 dbSNP
rs1313708937 48 dbSNP
rs1199167306 49 dbSNP
rs1030813575 50 dbSNP
rs1265153023 51 dbSNP
rs113030493 54 dbSNP
rs565856283 56 dbSNP
rs991886958 72 dbSNP
rs1307038402 73 dbSNP
rs1270998460 93 dbSNP
rs956616845 99 dbSNP
rs1351143025 110 dbSNP
rs1021249227 111 dbSNP
rs534881287 116 dbSNP
rs915166969 117 dbSNP
rs979348798 124 dbSNP
rs964028641 131 dbSNP
rs1441055000 139 dbSNP
rs1465639470 139 dbSNP
rs200239586 139 dbSNP
rs201518254 139 dbSNP
rs555034592 139 dbSNP
rs878954736 139 dbSNP
rs886052600 139 dbSNP
rs886052601 139 dbSNP
rs762095727 141 dbSNP
rs1425049474 142 dbSNP
rs74342589 152 dbSNP
rs1386342086 153 dbSNP
rs886052602 153 dbSNP
rs879003213 154 dbSNP
rs1320943035 155 dbSNP
rs1366258746 156 dbSNP
rs1227982889 158 dbSNP
rs1236513087 163 dbSNP
rs953942489 170 dbSNP
rs1458258725 181 dbSNP
rs1262477519 185 dbSNP
rs1207909865 187 dbSNP
rs985440503 193 dbSNP
rs1301760730 195 dbSNP
rs1222932781 207 dbSNP
rs1370747320 210 dbSNP
rs1323587659 217 dbSNP
rs975120964 230 dbSNP
rs912531291 231 dbSNP
rs922335150 235 dbSNP
rs944123418 245 dbSNP
rs1336699547 249 dbSNP
rs1463933654 251 dbSNP
rs1465000448 257 dbSNP
rs1221579890 265 dbSNP
rs1361365353 273 dbSNP
rs567457401 274 dbSNP
rs1418802352 276 dbSNP
rs1378761177 284 dbSNP
rs1180712179 293 dbSNP
rs750646095 295 dbSNP
rs8076247 298 dbSNP
rs183903455 299 dbSNP
rs941546985 300 dbSNP
rs557163590 302 dbSNP
rs1484199591 304 dbSNP
rs143758001 306 dbSNP
rs1214882970 308 dbSNP
rs573026653 318 dbSNP
rs368791319 320 dbSNP
rs11078233 323 dbSNP
rs1381518440 331 dbSNP
rs1312312917 335 dbSNP
rs1458727983 343 dbSNP
rs1321086195 351 dbSNP
rs1013303600 352 dbSNP
rs1045759022 356 dbSNP
rs907276647 357 dbSNP
rs1160776139 358 dbSNP
rs1013789256 365 dbSNP
rs1384773469 371 dbSNP
rs11078234 372 dbSNP
rs1425620914 373 dbSNP
rs1256864899 380 dbSNP
rs966542131 381 dbSNP
rs1000674901 382 dbSNP
rs1415547434 382 dbSNP
rs1030782217 385 dbSNP
rs1217014758 396 dbSNP
rs1358290125 397 dbSNP
rs956502633 400 dbSNP
rs886052603 409 dbSNP
rs1327767942 411 dbSNP
rs1230801261 413 dbSNP
rs1269241958 423 dbSNP
rs1010760230 424 dbSNP
rs953971887 427 dbSNP
rs1022607159 428 dbSNP
rs146848128 438 dbSNP
rs75823746 439 dbSNP
rs1339040987 442 dbSNP
rs560578836 454 dbSNP
rs751457905 455 dbSNP
rs757031938 459 dbSNP
rs955102373 461 dbSNP
rs965399188 464 dbSNP
rs1459549195 465 dbSNP
rs973257196 468 dbSNP
rs918660319 469 dbSNP
rs1476816776 476 dbSNP
rs1425599659 478 dbSNP
rs982494983 484 dbSNP
rs529638594 485 dbSNP
rs931361027 486 dbSNP
rs1483353725 488 dbSNP
rs1048606415 499 dbSNP
rs908293617 506 dbSNP
rs1249011767 510 dbSNP
rs543545046 513 dbSNP
rs1159857335 514 dbSNP
rs1424315688 524 dbSNP
rs563239177 527 dbSNP
rs886052604 536 dbSNP
rs1316610718 556 dbSNP
rs916135773 560 dbSNP
rs1057374685 561 dbSNP
rs1330857747 564 dbSNP
rs886052605 564 dbSNP
rs532204640 568 dbSNP
rs79156487 581 dbSNP
rs1321880763 591 dbSNP
rs886052606 591 dbSNP
rs1391670969 609 dbSNP
rs1330763195 618 dbSNP
rs949020072 624 dbSNP
rs896170780 626 dbSNP
rs886052607 629 dbSNP
rs907245531 633 dbSNP
rs934668785 635 dbSNP
rs552101577 644 dbSNP
rs189358985 646 dbSNP
rs7214082 647 dbSNP
rs1307585100 648 dbSNP
rs1348747550 649 dbSNP
rs1411688525 651 dbSNP
rs140898783 653 dbSNP
rs537449689 654 dbSNP
rs1367482301 662 dbSNP
rs893235842 668 dbSNP
rs1199799323 675 dbSNP
rs370121669 676 dbSNP
rs1273471040 686 dbSNP
rs1011146047 687 dbSNP
rs1331912457 699 dbSNP
rs557278632 701 dbSNP
rs1022154516 703 dbSNP
rs1000537587 704 dbSNP
rs1167594718 713 dbSNP
rs1348978006 714 dbSNP
rs1332013894 719 dbSNP
rs1413872062 719 dbSNP
rs1204006408 720 dbSNP
rs1174121283 721 dbSNP
rs1271990818 725 dbSNP
rs1466349860 730 dbSNP
rs886052608 740 dbSNP
rs1032138928 743 dbSNP
rs953879063 755 dbSNP
rs899745912 756 dbSNP
rs1802618 758 dbSNP
rs768093978 769 dbSNP
rs539889703 770 dbSNP
rs878888179 772 dbSNP
rs1428787255 776 dbSNP
rs1346144270 782 dbSNP
rs180754993 784 dbSNP
rs1238219051 785 dbSNP
rs1379345888 792 dbSNP
rs982462174 814 dbSNP
rs1168226644 815 dbSNP
rs1447315933 816 dbSNP
rs972777031 818 dbSNP
rs886052609 824 dbSNP
rs1414867581 825 dbSNP
rs1270985756 831 dbSNP
rs1359643212 831 dbSNP
rs397763766 831 dbSNP
rs201044094 834 dbSNP
rs1329621869 847 dbSNP
rs1349871479 848 dbSNP
rs962519934 857 dbSNP
rs974629254 860 dbSNP
rs1471514204 861 dbSNP
rs1372221637 865 dbSNP
rs916118980 874 dbSNP
rs1190181991 878 dbSNP
rs1228063597 882 dbSNP
rs993513282 888 dbSNP
rs917528121 893 dbSNP
rs573080780 895 dbSNP
rs1195941102 899 dbSNP
rs75839697 905 dbSNP
rs928892059 906 dbSNP
rs762344226 910 dbSNP
rs1354304662 915 dbSNP
rs1285937376 916 dbSNP
rs1449312979 921 dbSNP
rs772348744 922 dbSNP
rs1053079453 931 dbSNP
rs555631251 936 dbSNP
rs1042063921 951 dbSNP
rs1247167805 954 dbSNP
rs1322465929 955 dbSNP
rs1403136878 957 dbSNP
rs893194386 961 dbSNP
rs1163282332 963 dbSNP
rs1475823652 968 dbSNP
rs2071245 975 dbSNP
rs1043942475 982 dbSNP
rs1388626342 986 dbSNP
rs1451546109 990 dbSNP
rs1168652564 992 dbSNP
rs543071969 994 dbSNP
rs996686074 996 dbSNP
rs1403637817 999 dbSNP
rs1450038556 1002 dbSNP
rs1326135885 1003 dbSNP
rs1292161032 1014 dbSNP
rs1228891828 1019 dbSNP
rs1276209506 1020 dbSNP
rs1317232600 1020 dbSNP
rs1395828377 1020 dbSNP
rs1220305698 1021 dbSNP
rs1006706409 1022 dbSNP
rs1019842240 1028 dbSNP
rs1351219563 1029 dbSNP
rs1029561397 1032 dbSNP
rs761021294 1037 dbSNP
rs891060099 1038 dbSNP
rs1318950589 1041 dbSNP
rs1169125692 1048 dbSNP
rs766704964 1049 dbSNP
rs901101671 1059 dbSNP
rs1366983898 1062 dbSNP
rs570342762 1067 dbSNP
rs1015291823 1076 dbSNP
rs1050216 1077 dbSNP
rs13183 1079 dbSNP
rs116445114 1080 dbSNP
rs1273785029 1081 dbSNP
rs1256123527 1091 dbSNP
rs1200429691 1097 dbSNP
rs75165393 1102 dbSNP
rs1300368496 1108 dbSNP
rs1206653886 1115 dbSNP
rs1369359178 1118 dbSNP
rs528282657 1119 dbSNP
rs1275071487 1122 dbSNP
rs1445455905 1124 dbSNP
rs751472685 1125 dbSNP
rs1373989932 1141 dbSNP
rs928879246 1142 dbSNP
rs184939367 1146 dbSNP
rs988771587 1147 dbSNP
rs151138383 1149 dbSNP
rs1355562694 1161 dbSNP
rs1194207682 1164 dbSNP
rs947383425 1166 dbSNP
rs1368065281 1170 dbSNP
rs1413104724 1175 dbSNP
rs1039079719 1176 dbSNP
rs15046 1183 dbSNP
rs189403720 1189 dbSNP
rs1439212414 1193 dbSNP
rs1165043454 1200 dbSNP
rs140067025 1201 dbSNP
rs1480921086 1212 dbSNP
rs1457162593 1215 dbSNP
rs150302052 1217 dbSNP
rs891030488 1218 dbSNP
rs1004171830 1221 dbSNP
rs1280662078 1239 dbSNP
rs1391288796 1253 dbSNP
rs923643911 1255 dbSNP
rs75844637 1268 dbSNP
rs1053491315 1285 dbSNP
rs1338308762 1293 dbSNP
rs889549673 1295 dbSNP
rs547070219 1298 dbSNP
rs1446331612 1300 dbSNP
rs1361235901 1301 dbSNP
rs898124484 1302 dbSNP
rs995581493 1312 dbSNP
rs1419361742 1316 dbSNP
rs1327803421 1321 dbSNP
rs1378629094 1323 dbSNP
rs1226502967 1324 dbSNP
rs75636595 1325 dbSNP
rs969810750 1337 dbSNP
rs143735639 1347 dbSNP
rs994135200 1350 dbSNP
rs1025557957 1352 dbSNP
rs1258006906 1356 dbSNP
rs1199642072 1359 dbSNP
rs1215543541 1363 dbSNP
rs555512140 1368 dbSNP
rs1035861407 1375 dbSNP
rs1351076366 1377 dbSNP
rs956285712 1378 dbSNP
rs145948022 1384 dbSNP
rs1050223 1386 dbSNP
rs556710307 1393 dbSNP
rs1034323463 1401 dbSNP
rs576768523 1404 dbSNP
rs1258327812 1418 dbSNP
rs1472265600 1434 dbSNP
rs975162485 1441 dbSNP
rs922026128 1442 dbSNP
rs1358942274 1449 dbSNP
rs1300242789 1454 dbSNP
rs574015313 1459 dbSNP
rs933414698 1459 dbSNP
rs1367992585 1461 dbSNP
rs1050912877 1462 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions TZM-bl
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM1462574. RNA binding protein: AGO2. Condition:TZM-bl ami BaL ...

- Whisnant AW; Bogerd HP; Flores O; Ho P; et al., 2013, mBio.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' cgggcuggaGUGGGUGGGGc 5'
                   | |||||||| 
Target 5' ---------CCCCCACCCCa 3'
 		1 - 11
Article - Whisnant AW; Bogerd HP; Flores O; Ho P; et al.
- mBio, 2013
UNLABELLED: The question of how HIV-1 interfaces with cellular microRNA (miRNA) biogenesis and effector mechanisms has been highly controversial. Here, we first used deep sequencing of small RNAs present in two different infected cell lines (TZM-bl and C8166) and two types of primary human cells (CD4(+) peripheral blood mononuclear cells [PBMCs] and macrophages) to unequivocally demonstrate that HIV-1 does not encode any viral miRNAs. Perhaps surprisingly, we also observed that infection of T cells by HIV-1 has only a modest effect on the expression of cellular miRNAs at early times after infection. Comprehensive analysis of miRNA binding to the HIV-1 genome using the photoactivatable ribonucleoside-induced cross-linking and immunoprecipitation (PAR-CLIP) technique revealed several binding sites for cellular miRNAs, a subset of which were shown to be capable of mediating miRNA-mediated repression of gene expression. However, the main finding from this analysis is that HIV-1 transcripts are largely refractory to miRNA binding, most probably due to extensive viral RNA secondary structure. Together, these data demonstrate that HIV-1 neither encodes viral miRNAs nor strongly influences cellular miRNA expression, at least early after infection, and imply that HIV-1 transcripts have evolved to avoid inhibition by preexisting cellular miRNAs by adopting extensive RNA secondary structures that occlude most potential miRNA binding sites. IMPORTANCE: MicroRNAs (miRNAs) are a ubiquitous class of small regulatory RNAs that serve as posttranscriptional regulators of gene expression. Previous work has suggested that HIV-1 might subvert the function of the cellular miRNA machinery by expressing viral miRNAs or by dramatically altering the level of cellular miRNA expression. Using very sensitive approaches, we now demonstrate that neither of these ideas is in fact correct. Moreover, HIV-1 transcripts appear to largely avoid regulation by cellular miRNAs by adopting an extensive RNA secondary structure that occludes the ability of cellular miRNAs to interact with viral mRNAs. Together, these data suggest that HIV-1, rather than seeking to control miRNA function in infected cells, has instead evolved a mechanism to become largely invisible to cellular miRNA effector mechanisms.
LinkOut: [PMID: 23592263]
CLIP-seq Support 1 for dataset GSM4903833
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / CTL_TD_21_a
Location of target site NM_001303 | 3UTR | GGGUAGCCCUGGACUUAAUACCAGCCGGAUACCUCUGGCCCCCACCCCAUUACUGUACCUCUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM4903834
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / CTL_TD_21_b
Location of target site NM_001303 | 3UTR | UACCUCUGGCCCCCACCCCAUUACUGUACCUCUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 3 for dataset GSM4903835
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / CTL_TD_21_c
Location of target site NM_001303 | 3UTR | UAGCCCUGGACUUAAUACCAGCCGGAUACCUCUGGCCCCCACCCCAUUACUGUACCUCUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 4 for dataset GSM4903836
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / 124_TD_21_a
Location of target site NM_001303 | 3UTR | UACCAGCCGGAUACCUCUGGCCCCCACCCCAUUACUGUACCUCUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 5 for dataset GSM4903837
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / 124_TD_21_b
Location of target site NM_001303 | 3UTR | AGGGUAGCCCUGGACUUAAUACCAGCCGGAUACCUCUGGCCCCCACCCCAUUACUGUACCUCUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 6 for dataset GSM4903838
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / 124_TD_21_c
Location of target site NM_001303 | 3UTR | GGAUACCUCUGGCCCCCACCCCAUUACUGUACCUCUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 7 for dataset GSM1462574
Method / RBP PAR-CLIP / AGO2
Cell line / Condition TZM-bl / TZM-bl ami BaL
Location of target site ENST00000261643.3 | 3UTR | CCCCCACCCCAUUACUGUACCUCUGGAGUCACUACUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23592263 / GSE59944
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
121 hsa-miR-4651 Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT066212 MARCH9 membrane associated ring-CH-type finger 9 2 2
MIRT113270 TMBIM6 transmembrane BAX inhibitor motif containing 6 2 2
MIRT115795 CAPN15 calpain 15 2 2
MIRT125296 MID1IP1 MID1 interacting protein 1 2 2
MIRT145419 ANKRD13B ankyrin repeat domain 13B 2 2
MIRT153779 NCOA3 nuclear receptor coactivator 3 2 2
MIRT189384 TXLNA taxilin alpha 2 4
MIRT451063 PNMAL2 paraneoplastic Ma antigen family member 8B 2 2
MIRT451142 C19orf53 chromosome 19 open reading frame 53 2 2
MIRT452374 LY6E lymphocyte antigen 6 family member E 2 4
MIRT452788 FAM136A family with sequence similarity 136 member A 2 2
MIRT452985 CABP4 calcium binding protein 4 2 2
MIRT453231 FTSJ3 FtsJ RNA methyltransferase homolog 3 2 2
MIRT453824 SAA1 serum amyloid A1 2 2
MIRT454136 FOXRED2 FAD dependent oxidoreductase domain containing 2 2 2
MIRT455104 NKX2-2 NK2 homeobox 2 2 6
MIRT455250 DDX39B DExD-box helicase 39B 2 10
MIRT456899 DDA1 DET1 and DDB1 associated 1 2 2
MIRT457099 DCX doublecortin 2 2
MIRT457761 ZC3H12B zinc finger CCCH-type containing 12B 2 4
MIRT458539 CYP2B6 cytochrome P450 family 2 subfamily B member 6 2 2
MIRT459011 UQCRH ubiquinol-cytochrome c reductase hinge protein 2 2
MIRT459197 RCE1 Ras converting CAAX endopeptidase 1 2 2
MIRT459295 PHYKPL 5-phosphohydroxy-L-lysine phospho-lyase 2 2
MIRT459466 MUC17 mucin 17, cell surface associated 2 4
MIRT459598 KCNK3 potassium two pore domain channel subfamily K member 3 2 2
MIRT461274 COX10 COX10, heme A:farnesyltransferase cytochrome c oxidase assembly factor 2 2
MIRT464551 UBTF upstream binding transcription factor, RNA polymerase I 2 2
MIRT465253 TRIM44 tripartite motif containing 44 2 2
MIRT465274 TRIM28 tripartite motif containing 28 2 2
MIRT465402 TP53 tumor protein p53 2 2
MIRT465877 TMEM43 transmembrane protein 43 2 4
MIRT466234 TMED10 transmembrane p24 trafficking protein 10 2 2
MIRT467027 SRSF1 serine and arginine rich splicing factor 1 2 4
MIRT468320 SF3B3 splicing factor 3b subunit 3 2 2
MIRT468437 SETD1B SET domain containing 1B 2 2
MIRT468691 SEC22C SEC22 homolog C, vesicle trafficking protein 2 4
MIRT468863 RREB1 ras responsive element binding protein 1 2 2
MIRT469779 RAB15 RAB15, member RAS oncogene family 2 2
MIRT470314 PPP6R1 protein phosphatase 6 regulatory subunit 1 2 2
MIRT470765 PNPLA6 patatin like phospholipase domain containing 6 2 2
MIRT472213 NGFR nerve growth factor receptor 2 2
MIRT472520 NACC1 nucleus accumbens associated 1 2 2
MIRT473281 MFRP membrane frizzled-related protein 2 2
MIRT473403 MDM4 MDM4, p53 regulator 2 2
MIRT473521 MAX MYC associated factor X 2 2
MIRT474529 KLHDC8A kelch domain containing 8A 2 2
MIRT474631 KLF16 Kruppel like factor 16 2 2
MIRT475130 IP6K1 inositol hexakisphosphate kinase 1 2 2
MIRT475808 HDGF heparin binding growth factor 2 2
MIRT478623 CTDNEP1 CTD nuclear envelope phosphatase 1 2 2
MIRT479501 CDH6 cadherin 6 2 2
MIRT479865 CCDC6 coiled-coil domain containing 6 2 2
MIRT480132 CALR calreticulin 2 2
MIRT480529 C10orf76 chromosome 10 open reading frame 76 2 2
MIRT480774 BMP2 bone morphogenetic protein 2 2 2
MIRT481423 ASB6 ankyrin repeat and SOCS box containing 6 2 2
MIRT481778 APEX1 apurinic/apyrimidinic endodeoxyribonuclease 1 2 2
MIRT481821 AP2M1 adaptor related protein complex 2 mu 1 subunit 2 2
MIRT482698 XRCC3 X-ray repair cross complementing 3 2 2
MIRT482976 CSTF2 cleavage stimulation factor subunit 2 2 2
MIRT483391 SPATA6 spermatogenesis associated 6 2 4
MIRT483429 RHOXF2B Rhox homeobox family member 2B 2 2
MIRT483476 STMN3 stathmin 3 2 4
MIRT483687 CYP11A1 cytochrome P450 family 11 subfamily A member 1 2 2
MIRT483803 CYP2W1 cytochrome P450 family 2 subfamily W member 1 2 6
MIRT484335 EPN1 epsin 1 2 4
MIRT484683 PACSIN1 protein kinase C and casein kinase substrate in neurons 1 2 2
MIRT484966 UCK1 uridine-cytidine kinase 1 2 2
MIRT485987 YIPF2 Yip1 domain family member 2 2 2
MIRT486773 SESTD1 SEC14 and spectrin domain containing 1 2 4
MIRT487372 C10orf54 V-set immunoregulatory receptor 2 2
MIRT487632 ONECUT3 one cut homeobox 3 2 4
MIRT488080 DLGAP3 DLG associated protein 3 2 4
MIRT488158 PRRC2B proline rich coiled-coil 2B 2 4
MIRT488463 B3GALNT2 beta-1,3-N-acetylgalactosaminyltransferase 2 2 2
MIRT490948 PPM1F protein phosphatase, Mg2+/Mn2+ dependent 1F 2 2
MIRT491719 RTN4R reticulon 4 receptor 2 2
MIRT492338 SEPT8 septin 8 2 2
MIRT493038 NAA50 N(alpha)-acetyltransferase 50, NatE catalytic subunit 2 2
MIRT493368 KIAA1614 KIAA1614 2 2
MIRT499384 PLCG2 phospholipase C gamma 2 2 11
MIRT499596 ANKRD45 ankyrin repeat domain 45 2 2
MIRT499730 USH1G USH1 protein network component sans 2 4
MIRT500357 ZNF385A zinc finger protein 385A 2 2
MIRT501691 PCGF3 polycomb group ring finger 3 2 6
MIRT504502 PPP1R9B protein phosphatase 1 regulatory subunit 9B 2 2
MIRT509579 HIST2H2AB histone cluster 2 H2A family member b 2 4
MIRT510610 TPM3 tropomyosin 3 2 2
MIRT512803 GLRX glutaredoxin 2 2
MIRT513302 SETBP1 SET binding protein 1 2 2
MIRT514005 CECR2 CECR2, histone acetyl-lysine reader 2 4
MIRT515701 ZNF321P zinc finger protein 321, pseudogene 2 2
MIRT518260 LEAP2 liver enriched antimicrobial peptide 2 2 2
MIRT523183 HIST3H3 histone cluster 3 H3 2 2
MIRT524051 DNAJC8 DnaJ heat shock protein family (Hsp40) member C8 2 2
MIRT538642 CCSAP centriole, cilia and spindle associated protein 2 2
MIRT541497 ADM adrenomedullin 2 2
MIRT569279 PTPRF protein tyrosine phosphatase, receptor type F 2 2
MIRT570279 ARPC3 actin related protein 2/3 complex subunit 3 2 2
MIRT570326 ZBTB7A zinc finger and BTB domain containing 7A 2 2
MIRT571451 YKT6 YKT6 v-SNARE homolog 2 2
MIRT571597 TOB2 transducer of ERBB2, 2 2 2
MIRT574894 Plcg2 phospholipase C, gamma 2 2 7
MIRT607551 GLI2 GLI family zinc finger 2 2 2
MIRT607694 MAPK10 mitogen-activated protein kinase 10 2 2
MIRT609983 PPARA peroxisome proliferator activated receptor alpha 2 2
MIRT610076 CRLF1 cytokine receptor like factor 1 2 2
MIRT610578 CACUL1 CDK2 associated cullin domain 1 2 4
MIRT626322 LRTOMT leucine rich transmembrane and O-methyltransferase domain containing 2 2
MIRT634011 RIF1 replication timing regulatory factor 1 2 2
MIRT642680 KRT74 keratin 74 2 2
MIRT689717 ATXN2 ataxin 2 2 2
MIRT691175 APOL6 apolipoprotein L6 2 2
MIRT693169 NPR1 natriuretic peptide receptor 1 2 2
MIRT697121 OTUD5 OTU deubiquitinase 5 2 2
MIRT711817 ELN elastin 2 2
MIRT721551 FXN frataxin 2 2
MIRT721666 SLFN12 schlafen family member 12 2 2
MIRT723760 NKIRAS2 NFKB inhibitor interacting Ras like 2 2 2
MIRT737362 FOXP4 forkhead box P4 2 0
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-4 Dexamethasone approved 5743 Microarray primary rat thymocytes 20847043 2010 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-4651 Platinum 23939 sensitive High Ovarian Cancer tissue
hsa-miR-4651 Imatinib 5291 NSC743414 approved sensitive High Gastrointestinal Stromal Tumor cell line (882R-NC, 882R-OE, 882R-KD)
hsa-miR-4651 Cisplatin 5460033 NSC119875 approved resistant High Pancreatic Cancer cell line (BxPC-3)
hsa-miR-4651 Dabrafenib 44462760 NSC764134 approved resistant High Melanoma cell line (A375, IGR37, 501Mel)
hsa-miR-4651 Vemurafenib 42611257 NSC761431 approved resistant High Melanoma cell line (A375, IGR37, 501Mel)
hsa-miR-4651 Curcumin 969516 NSC32982 approved sensitive High Breast Cancer cell line (MCF-7)
hsa-miR-4651 Doxorubicin 31703 NSC123127 approved sensitive High Breast Cancer cell line (MCF-7)
hsa-miR-4651 Paclitaxel 36314 NSC125973 approved resistant High Non-Small Cell Lung Cancer cell line (A549)
hsa-miR-4651 Fulvestrant 17756771 NSC719276 approved resistant High Breast Cancer cell line (MCF-7)
hsa-mir-4651 Dabrafenib 44462760 NSC764134 approved resistant cell line (A375)
hsa-mir-4651 Cisplatin 5460033 NSC119875 approved resistant cell line (BxPC3)
hsa-miR-4651 Osimertinib 71496458 NSC779217 approved resistant cell line (PC9)
hsa-miR-4651 Cisplatin 5460033 NSC119875 approved resistant cell line (CAL-27) (cytosolic RNA)
hsa-miR-4651 Cisplatin 5460033 NSC119875 approved resistant cell line (CAL-27) (total RNA)
hsa-miR-4651 Cisplatin 5460033 NSC119875 approved sensitive cell line
hsa-miR-4651 Doxorubicin 31703 NSC123127 approved resistant cell line (HS578T)
hsa-miR-4651 Doxorubicin 31703 NSC123127 approved resistant cell line (BAS)
hsa-miR-4651 Cisplatin 5460033 NSC119875 approved resistant cell line (CIS)
hsa-miR-4651 Cisplatin 5460033 NSC119875 approved resistant cell line (CP20)
hsa-miR-4651 Osimertinib 71496458 NSC779217 approved sensitive cell line (H1975)
hsa-miR-4651 Vemurafenib 42611257 NSC761431 approved sensitive cell line (LM16)
hsa-miR-4651 Neoadjuvant chemotherapy sensitive tissue (breast cancer)
hsa-miR-4651 Neoadjuvant chemotherapy sensitive tissue (breast cancer)
hsa-miR-4651 Gemcitabine 60750 NSC613327 approved resistant cell line (PANC-1) (1500 ng/ml)
hsa-miR-4651 Gemcitabine 60750 NSC613327 approved resistant cell line (PANC-1) (100 ng/ml)
hsa-miR-4651 Gemcitabine 60750 NSC613327 approved resistant cell line (Panc1-GR4)

Error report submission