pre-miRNA Information
pre-miRNA hsa-mir-1303   
Genomic Coordinates chr5: 154685776 - 154685861
Synonyms MIRN1303, hsa-mir-1303, MIR1303
Description Homo sapiens miR-1303 stem-loop
Comment None
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-1303
Sequence 52| UUUAGAGACGGGGUCUUGCUCU |73
Evidence Experimental
Experiments Illumina
Editing Events in miRNAs
Modification Type Position on miR Chromosome DNA Strand Genomic Position (hg38) List of PMIDs Variant details
A-to-I 4 5 + 154685830 23291724, 29233923 MiREDiBase
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs370437195 6 dbSNP
rs1195001383 7 dbSNP
rs546614687 8 dbSNP
rs762579883 9 dbSNP
rs766041486 10 dbSNP
rs751079975 12 dbSNP
rs888516744 13 dbSNP
rs566454487 14 dbSNP
rs766973220 15 dbSNP
rs1474274822 17 dbSNP
rs753222192 18 dbSNP
rs1230907999 19 dbSNP
rs756552638 22 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol NUP133   
Synonyms hNUP133
Description nucleoporin 133
Transcript NM_018230   
Expression
Putative miRNA Targets on NUP133
3'UTR of NUP133
(miRNA target sites are highlighted)
>NUP133|NM_018230|3'UTR
   1 CTTTTTCTAAAAATGGCCATTGTTTATGAAATCTGTATAAGTGTGTCCTTATACAAATTTTAGGCCATAAACAAGTGTAA
  81 GTTTGTACAATTTCATAACATGTATAGCTGAGTTTTTATACTTTATATGTAGGAAGCTAATATAAAATAGTTATGTAACT
 161 GTGATTTTGGTTTTCAGTTATGTGACTTGTTTTTTCCACCTGAAATGTGTCAGTTGTTGTTCCTGTACTCGGTGCCCTTT
 241 CTTTTTACTCTCACGTGGTCCCAGGTTCTGGAGTTCTTGTCCTGGTTCTAGCTGCTCACATGTACAAATCACTTCTAGGC
 321 CTCAGTTTCTGCGACTATGAAAATTACTAGATTGCACTAGCTTGTCTCTAAAATTGCTGTGACTCCAGATACTTTGCACT
 401 GAAGAGAATCTAGGGTGTTTGATATCTGTTTCAGTTAGGGCTAATGGGAAATGTCTAGTAAGATAAATGTCAACTTTTGC
 481 TGACTTATTATGAGATGAAAAACCAAAGGAGAGTGGGCCTAACTCATGTGAGCTTGATAACTGATGAACTCATTGGGAGC
 561 ATTTTAAACTTTTCTACATAAATAATAAATGAGCACTAATGAAAGTA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' ucuCGUUCUGGGGCAGAGAUUu 5'
             |||  | |::|||||||| 
Target 5' attGCACTAGCTTGTCTCTAAa 3'
351 - 372 163.00 -17.10
2
miRNA  3' ucucGUUCUGGGG-CAGAGAUuu 5'
              | ||:||:| ||:|||:  
Target 5' acttCTAGGCCTCAGTTTCTGcg 3'
311 - 333 114.00 -16.30
3
miRNA  3' ucUCGU----UCUGGGGCAGAGAUuu 5'
            ||||    | ||:   |:||||  
Target 5' ggAGCATTTTAAACT---TTTCTAca 3'
556 - 578 111.00 -8.22
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30149391 7 COSMIC
COSN4748562 53 COSMIC
COSN28859118 91 COSMIC
COSN31518634 104 COSMIC
COSN31558161 167 COSMIC
COSN30659950 255 COSMIC
COSN30125523 384 COSMIC
COSN18725125 422 COSMIC
COSN8437265 428 COSMIC
COSN30497748 442 COSMIC
COSN30748387 442 COSMIC
COSN31535703 443 COSMIC
COSN30509861 449 COSMIC
COSN31496186 494 COSMIC
COSN31567977 497 COSMIC
COSN30467981 508 COSMIC
COSN28632961 540 COSMIC
COSN15859481 543 COSMIC
COSN31485933 567 COSMIC
COSN15857854 650 COSMIC
COSN6446443 686 COSMIC
COSN6026119 941 COSMIC
COSN26098200 962 COSMIC
COSN5367127 1144 COSMIC
COSN27519183 1596 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs541272905 4 dbSNP
rs368526058 7 dbSNP
rs759080960 12 dbSNP
rs201857748 16 dbSNP
rs1209767744 17 dbSNP
rs564524643 19 dbSNP
rs1445744487 26 dbSNP
rs748668207 31 dbSNP
rs1234006563 33 dbSNP
rs994585324 34 dbSNP
rs370829250 35 dbSNP
rs769273102 37 dbSNP
rs1411358120 38 dbSNP
rs747469092 39 dbSNP
rs112780444 42 dbSNP
rs377259967 44 dbSNP
rs1334272977 45 dbSNP
rs1035993023 49 dbSNP
rs1334180652 50 dbSNP
rs758692612 51 dbSNP
rs940369402 52 dbSNP
rs1445722314 58 dbSNP
rs759638290 64 dbSNP
rs1342577562 65 dbSNP
rs1229461380 69 dbSNP
rs1274224048 75 dbSNP
rs1340236595 77 dbSNP
rs1202256266 78 dbSNP
rs544633188 81 dbSNP
rs1042050760 85 dbSNP
rs1266038776 90 dbSNP
rs937285862 100 dbSNP
rs113646920 101 dbSNP
rs945065503 113 dbSNP
rs917818225 127 dbSNP
rs776879136 136 dbSNP
rs887917463 138 dbSNP
rs913327088 143 dbSNP
rs575730674 146 dbSNP
rs1217029241 148 dbSNP
rs760459019 164 dbSNP
rs556265639 166 dbSNP
rs1365779829 169 dbSNP
rs988733763 171 dbSNP
rs143771313 176 dbSNP
rs926438134 182 dbSNP
rs1020060931 187 dbSNP
rs1256716521 189 dbSNP
rs985037983 191 dbSNP
rs1326187856 194 dbSNP
rs770989573 198 dbSNP
rs952161277 199 dbSNP
rs1465698125 201 dbSNP
rs1027147043 202 dbSNP
rs1246569941 217 dbSNP
rs1434599208 219 dbSNP
rs995679993 230 dbSNP
rs1376612059 231 dbSNP
rs1476772276 232 dbSNP
rs148976092 236 dbSNP
rs972047276 238 dbSNP
rs1389296544 241 dbSNP
rs1014703519 246 dbSNP
rs1421774787 254 dbSNP
rs554888348 255 dbSNP
rs766367241 265 dbSNP
rs1388785989 272 dbSNP
rs1192670337 273 dbSNP
rs1057225892 280 dbSNP
rs1018976166 283 dbSNP
rs1007778348 284 dbSNP
rs1245933346 285 dbSNP
rs1185266005 286 dbSNP
rs889381322 291 dbSNP
rs1042837225 292 dbSNP
rs535292050 294 dbSNP
rs778000422 299 dbSNP
rs1489651611 300 dbSNP
rs1210766353 312 dbSNP
rs570192578 316 dbSNP
rs913290728 324 dbSNP
rs1431030536 325 dbSNP
rs189115529 332 dbSNP
rs1000808869 333 dbSNP
rs1472252305 334 dbSNP
rs772530825 337 dbSNP
rs1156820506 340 dbSNP
rs1370079453 354 dbSNP
rs1458242663 355 dbSNP
rs1292670861 362 dbSNP
rs988897157 376 dbSNP
rs558968545 394 dbSNP
rs1309999007 395 dbSNP
rs1351153204 398 dbSNP
rs944142950 406 dbSNP
rs1323975028 408 dbSNP
rs75443114 410 dbSNP
rs1265225543 412 dbSNP
rs1392846023 415 dbSNP
rs1206832595 421 dbSNP
rs945140557 422 dbSNP
rs746026658 424 dbSNP
rs1399580341 425 dbSNP
rs570152634 425 dbSNP
rs757265019 428 dbSNP
rs1183908241 432 dbSNP
rs377341223 451 dbSNP
rs764081236 457 dbSNP
rs1258200514 459 dbSNP
rs756001463 466 dbSNP
rs752577887 470 dbSNP
rs1163892377 474 dbSNP
rs767195636 475 dbSNP
rs1160903831 484 dbSNP
rs748634575 485 dbSNP
rs773807257 486 dbSNP
rs765998975 488 dbSNP
rs1230445466 491 dbSNP
rs1374392198 492 dbSNP
rs1274000327 496 dbSNP
rs1434072878 504 dbSNP
rs985898044 509 dbSNP
rs984623395 512 dbSNP
rs930502769 513 dbSNP
rs762608954 519 dbSNP
rs772844906 520 dbSNP
rs1312527602 522 dbSNP
rs779062471 525 dbSNP
rs769322445 526 dbSNP
rs954241637 528 dbSNP
rs919112047 535 dbSNP
rs866273093 547 dbSNP
rs1171276535 553 dbSNP
rs1409300010 564 dbSNP
rs972120990 565 dbSNP
rs779346073 569 dbSNP
rs550207595 574 dbSNP
rs1018925683 578 dbSNP
rs1181186549 589 dbSNP
rs1483569891 589 dbSNP
rs920175915 596 dbSNP
rs1451129644 598 dbSNP
rs1179728497 599 dbSNP
rs1188908579 600 dbSNP
rs530139890 617 dbSNP
rs974212015 623 dbSNP
rs755511696 624 dbSNP
rs1360944935 628 dbSNP
rs1467038878 634 dbSNP
rs961553199 647 dbSNP
rs1232948118 649 dbSNP
rs1269197241 654 dbSNP
rs1381167171 669 dbSNP
rs10916477 686 dbSNP
rs557605890 706 dbSNP
rs767427070 707 dbSNP
rs1033701955 720 dbSNP
rs1298712269 738 dbSNP
rs1212422354 742 dbSNP
rs1481793256 742 dbSNP
rs773890091 742 dbSNP
rs1000354412 766 dbSNP
rs1312225524 770 dbSNP
rs1208767742 782 dbSNP
rs1004619471 788 dbSNP
rs1273020341 791 dbSNP
rs1248837574 800 dbSNP
rs1247170869 801 dbSNP
rs967919605 804 dbSNP
rs779554067 807 dbSNP
rs547288659 814 dbSNP
rs1427484834 831 dbSNP
rs896247814 834 dbSNP
rs1056049124 845 dbSNP
rs755708855 847 dbSNP
rs1404546039 851 dbSNP
rs145539110 872 dbSNP
rs1459277907 872 dbSNP
rs1049423174 876 dbSNP
rs1428258303 883 dbSNP
rs930596516 897 dbSNP
rs1367807618 903 dbSNP
rs80145187 904 dbSNP
rs1368796037 906 dbSNP
rs1280731168 910 dbSNP
rs1036206538 913 dbSNP
rs1331214965 914 dbSNP
rs1339419756 914 dbSNP
rs891612272 925 dbSNP
rs1445098856 929 dbSNP
rs1223439891 931 dbSNP
rs944767545 932 dbSNP
rs1367643145 933 dbSNP
rs1162507609 935 dbSNP
rs1488893313 940 dbSNP
rs185648967 941 dbSNP
rs1198877843 942 dbSNP
rs1473884127 943 dbSNP
rs1420488761 946 dbSNP
rs538898982 960 dbSNP
rs1160509913 962 dbSNP
rs1053400565 970 dbSNP
rs912016660 974 dbSNP
rs1325875224 987 dbSNP
rs986110380 988 dbSNP
rs1435294316 999 dbSNP
rs953530457 1012 dbSNP
rs562350837 1013 dbSNP
rs1471299259 1014 dbSNP
rs1287677810 1016 dbSNP
rs1348387722 1018 dbSNP
rs1270435369 1027 dbSNP
rs1225346192 1031 dbSNP
rs1490669109 1032 dbSNP
rs912645390 1034 dbSNP
rs73112268 1035 dbSNP
rs932655120 1044 dbSNP
rs193107191 1045 dbSNP
rs1307896732 1046 dbSNP
rs528034908 1047 dbSNP
rs1484092826 1048 dbSNP
rs762042176 1054 dbSNP
rs1014409864 1055 dbSNP
rs1468993189 1055 dbSNP
rs1414952781 1059 dbSNP
rs960426073 1067 dbSNP
rs558912025 1068 dbSNP
rs1034760827 1074 dbSNP
rs1001974310 1077 dbSNP
rs1285317616 1078 dbSNP
rs1405477777 1081 dbSNP
rs908708537 1091 dbSNP
rs1306805167 1096 dbSNP
rs1333978915 1112 dbSNP
rs1450115778 1119 dbSNP
rs1389995283 1123 dbSNP
rs1284614658 1139 dbSNP
rs992771155 1142 dbSNP
rs904833720 1149 dbSNP
rs1289888221 1151 dbSNP
rs555127738 1159 dbSNP
rs1344514999 1160 dbSNP
rs1455089210 1167 dbSNP
rs1205962493 1169 dbSNP
rs1272369681 1172 dbSNP
rs1048725873 1175 dbSNP
rs995130297 1177 dbSNP
rs1035850983 1186 dbSNP
rs1238518274 1200 dbSNP
rs897777711 1200 dbSNP
rs1182074041 1202 dbSNP
rs1391640811 1203 dbSNP
rs34022152 1207 dbSNP
rs1166872803 1221 dbSNP
rs1429999338 1221 dbSNP
rs969682821 1236 dbSNP
rs1416140529 1250 dbSNP
rs541672188 1260 dbSNP
rs944543563 1264 dbSNP
rs1450199741 1275 dbSNP
rs187678158 1276 dbSNP
rs766534703 1277 dbSNP
rs1430755206 1280 dbSNP
rs891747893 1282 dbSNP
rs139845119 1291 dbSNP
rs539348947 1293 dbSNP
rs1461209418 1299 dbSNP
rs768994095 1300 dbSNP
rs747324658 1302 dbSNP
rs184423536 1305 dbSNP
rs1250277014 1310 dbSNP
rs1449753088 1313 dbSNP
rs191657720 1317 dbSNP
rs968025852 1318 dbSNP
rs73112267 1324 dbSNP
rs1478735366 1327 dbSNP
rs1487031024 1330 dbSNP
rs1261702575 1339 dbSNP
rs1172590973 1343 dbSNP
rs992944369 1343 dbSNP
rs960170005 1346 dbSNP
rs371464001 1347 dbSNP
rs1322361953 1354 dbSNP
rs1389063798 1356 dbSNP
rs1381404708 1363 dbSNP
rs1034497670 1364 dbSNP
rs534974536 1367 dbSNP
rs146424464 1368 dbSNP
rs1224136441 1370 dbSNP
rs1275512366 1372 dbSNP
rs1027724824 1378 dbSNP
rs1323521688 1379 dbSNP
rs547568027 1391 dbSNP
rs527523388 1392 dbSNP
rs897729798 1395 dbSNP
rs939533214 1396 dbSNP
rs1014881144 1400 dbSNP
rs928375680 1415 dbSNP
rs34816777 1421 dbSNP
rs1452907377 1423 dbSNP
rs890271926 1426 dbSNP
rs1427971411 1428 dbSNP
rs1479443105 1430 dbSNP
rs1161325256 1434 dbSNP
rs1362366928 1435 dbSNP
rs551217678 1436 dbSNP
rs1383164931 1439 dbSNP
rs932026011 1447 dbSNP
rs531525404 1449 dbSNP
rs1303891242 1451 dbSNP
rs1021237009 1459 dbSNP
rs77545425 1461 dbSNP
rs796578567 1462 dbSNP
rs1043448549 1467 dbSNP
rs1290774562 1468 dbSNP
rs370473038 1469 dbSNP
rs1238780038 1471 dbSNP
rs76148598 1476 dbSNP
rs1407923020 1477 dbSNP
rs139426522 1478 dbSNP
rs955941152 1479 dbSNP
rs116835530 1484 dbSNP
rs553795732 1485 dbSNP
rs541626541 1487 dbSNP
rs890938367 1491 dbSNP
rs755689928 1492 dbSNP
rs1430860225 1499 dbSNP
rs142732830 1503 dbSNP
rs980328805 1503 dbSNP
rs572629456 1504 dbSNP
rs898617613 1505 dbSNP
rs1309853171 1506 dbSNP
rs1374778966 1507 dbSNP
rs1391307430 1509 dbSNP
rs1038345675 1513 dbSNP
rs565480911 1514 dbSNP
rs10458374 1515 dbSNP
rs187095722 1516 dbSNP
rs1344334345 1517 dbSNP
rs961679528 1517 dbSNP
rs1356741520 1521 dbSNP
rs1206765190 1524 dbSNP
rs556504947 1525 dbSNP
rs1274717533 1530 dbSNP
rs1480298850 1538 dbSNP
rs1057132161 1541 dbSNP
rs756998747 1542 dbSNP
rs1424197847 1543 dbSNP
rs1182687168 1549 dbSNP
rs150794112 1558 dbSNP
rs11808231 1564 dbSNP
rs1422968084 1570 dbSNP
rs1170627647 1574 dbSNP
rs890386630 1582 dbSNP
rs1308078579 1583 dbSNP
rs1461955744 1594 dbSNP
rs1296586007 1602 dbSNP
rs980938475 1606 dbSNP
rs1453843220 1607 dbSNP
rs1314790585 1610 dbSNP
rs1029235565 1612 dbSNP
rs1380200589 1623 dbSNP
rs914324373 1624 dbSNP
rs989749428 1634 dbSNP
rs755852193 1641 dbSNP
rs955909159 1643 dbSNP
rs996063602 1646 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions TZM-bl
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM1462574. RNA binding protein: AGO2. Condition:TZM-bl ami BaL ...

- Whisnant AW; Bogerd HP; Flores O; Ho P; et al., 2013, mBio.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1
miRNA  3' ucucguucuggggcAGAGAUUu 5'
                        ||||||| 
Target 5' --------------UCUCUAAa 3'
1 - 8
Article - Whisnant AW; Bogerd HP; Flores O; Ho P; et al.
- mBio, 2013
UNLABELLED: The question of how HIV-1 interfaces with cellular microRNA (miRNA) biogenesis and effector mechanisms has been highly controversial. Here, we first used deep sequencing of small RNAs present in two different infected cell lines (TZM-bl and C8166) and two types of primary human cells (CD4(+) peripheral blood mononuclear cells [PBMCs] and macrophages) to unequivocally demonstrate that HIV-1 does not encode any viral miRNAs. Perhaps surprisingly, we also observed that infection of T cells by HIV-1 has only a modest effect on the expression of cellular miRNAs at early times after infection. Comprehensive analysis of miRNA binding to the HIV-1 genome using the photoactivatable ribonucleoside-induced cross-linking and immunoprecipitation (PAR-CLIP) technique revealed several binding sites for cellular miRNAs, a subset of which were shown to be capable of mediating miRNA-mediated repression of gene expression. However, the main finding from this analysis is that HIV-1 transcripts are largely refractory to miRNA binding, most probably due to extensive viral RNA secondary structure. Together, these data demonstrate that HIV-1 neither encodes viral miRNAs nor strongly influences cellular miRNA expression, at least early after infection, and imply that HIV-1 transcripts have evolved to avoid inhibition by preexisting cellular miRNAs by adopting extensive RNA secondary structures that occlude most potential miRNA binding sites. IMPORTANCE: MicroRNAs (miRNAs) are a ubiquitous class of small regulatory RNAs that serve as posttranscriptional regulators of gene expression. Previous work has suggested that HIV-1 might subvert the function of the cellular miRNA machinery by expressing viral miRNAs or by dramatically altering the level of cellular miRNA expression. Using very sensitive approaches, we now demonstrate that neither of these ideas is in fact correct. Moreover, HIV-1 transcripts appear to largely avoid regulation by cellular miRNAs by adopting an extensive RNA secondary structure that occludes the ability of cellular miRNAs to interact with viral mRNAs. Together, these data suggest that HIV-1, rather than seeking to control miRNA function in infected cells, has instead evolved a mechanism to become largely invisible to cellular miRNA effector mechanisms.
LinkOut: [PMID: 23592263]
CLIP-seq Support 1 for dataset GSM4903833
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / CTL_TD_21_a
Location of target site NM_018230 | 3UTR | ACUAUGAAAAUUACUAGAUUGCACUAGCUUGUCUCUAAAAUUGCUGUGACUCCAGAUACUUUGCACUGAAGAGAAUCUAGGGUGUUUGAUAUCU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM4903835
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / CTL_TD_21_c
Location of target site NM_018230 | 3UTR | UCUGCGACUAUGAAAAUUACUAGAUUGCACUAGCUUGUCUCUAAAAUUGCUGUGACUCCAGAUACUUUGCACUGAAGAGAAUCUAGGGUGUUUGAUAUCU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 3 for dataset GSM4903836
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / 124_TD_21_a
Location of target site NM_018230 | 3UTR | CACUAGCUUGUCUCUAAAAUUGCUGUGACUCCAGAUACUUUGCACUGAAGAGAAUCUAGGGUGUUUGAUAUCU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 4 for dataset GSM1462574
Method / RBP PAR-CLIP / AGO2
Cell line / Condition TZM-bl / TZM-bl ami BaL
Location of target site ENST00000261396.3 | 3UTR | UCUCUAAAAUUGCUGUGACUCCAG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23592263 / GSE59944
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
GSE32688 Pancreatic cancer -0.488 2.3e-3 -0.379 1.6e-2 32 Click to see details
GSE38226 Liver fibrosis 0.546 5.2e-3 0.304 9.0e-2 21 Click to see details
GSE28260 Renal cortex and medulla 0.673 5.9e-3 0.560 2.3e-2 13 Click to see details
GSE42095 Differentiated embryonic stem cells 0.297 8.4e-2 0.276 1.0e-1 23 Click to see details
GSE26953 Aortic valvular endothelial cells -0.213 1.6e-1 -0.195 1.8e-1 24 Click to see details
GSE28544 Breast cancer -0.096 3.3e-1 -0.015 4.7e-1 24 Click to see details
GSE38974 Chronic obstructive pulmonary disease 0.028 4.5e-1 -0.267 9.8e-2 25 Click to see details
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
186 hsa-miR-1303 Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT035871 SOAT1 sterol O-acyltransferase 1 1 1
MIRT035872 FHOD3 formin homology 2 domain containing 3 1 1
MIRT035873 RPL7A ribosomal protein L7a 1 1
MIRT035874 NCAPD2 non-SMC condensin I complex subunit D2 1 1
MIRT035875 RPS8 ribosomal protein S8 1 1
MIRT035876 AHNAK AHNAK nucleoprotein 1 1
MIRT035877 ACTB actin beta 1 1
MIRT035878 DEF8 differentially expressed in FDCP 8 homolog 1 1
MIRT035879 MET MET proto-oncogene, receptor tyrosine kinase 1 1
MIRT035880 MED13 mediator complex subunit 13 1 1
MIRT035881 FAT3 FAT atypical cadherin 3 1 1
MIRT035882 HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 1 1
MIRT035883 RPS16 ribosomal protein S16 1 1
MIRT035884 CDK6 cyclin dependent kinase 6 1 1
MIRT035885 GEMIN5 gem nuclear organelle associated protein 5 1 1
MIRT035886 PITRM1 pitrilysin metallopeptidase 1 1 1
MIRT035887 PRRC2A proline rich coiled-coil 2A 1 1
MIRT035888 KIAA0226 RUN and cysteine rich domain containing beclin 1 interacting protein 1 1
MIRT035889 MLLT6 MLLT6, PHD finger containing 1 1
MIRT035890 EIF3I eukaryotic translation initiation factor 3 subunit I 1 1
MIRT035891 FASN fatty acid synthase 1 1
MIRT035892 LEPREL4 prolyl 3-hydroxylase family member 4 (non-enzymatic) 1 1
MIRT035893 HSCB HscB mitochondrial iron-sulfur cluster cochaperone 1 1
MIRT035894 PSME4 proteasome activator subunit 4 1 1
MIRT035895 FRS2 fibroblast growth factor receptor substrate 2 1 1
MIRT035896 ZNF264 zinc finger protein 264 1 1
MIRT035897 HYLS1 HYLS1, centriolar and ciliogenesis associated 1 1
MIRT035898 USP54 ubiquitin specific peptidase 54 1 1
MIRT035899 L1TD1 LINE1 type transposase domain containing 1 1 1
MIRT035900 OR51E2 olfactory receptor family 51 subfamily E member 2 1 1
MIRT053762 CLDN18 claudin 18 3 1
MIRT060730 RPS3 ribosomal protein S3 2 2
MIRT083986 RAB22A RAB22A, member RAS oncogene family 2 2
MIRT098550 TBPL1 TATA-box binding protein like 1 2 6
MIRT134983 TWF1 twinfilin actin binding protein 1 2 4
MIRT136956 FNDC3A fibronectin type III domain containing 3A 2 2
MIRT222065 PURB purine rich element binding protein B 2 2
MIRT239574 UBN2 ubinuclein 2 2 4
MIRT261820 BUB3 BUB3, mitotic checkpoint protein 2 2
MIRT264698 C11ORF57 chromosome 11 open reading frame 57 2 4
MIRT308476 GXYLT2 glucoside xylosyltransferase 2 2 2
MIRT377481 NDUFB5 NADH:ubiquinone oxidoreductase subunit B5 2 2
MIRT442304 NEU3 neuraminidase 3 2 2
MIRT446083 SLC30A10 solute carrier family 30 member 10 2 2
MIRT449606 PRPF4 pre-mRNA processing factor 4 2 2
MIRT453767 NUCB1 nucleobindin 1 2 10
MIRT455603 SRSF3 serine and arginine rich splicing factor 3 2 2
MIRT455913 KIF2C kinesin family member 2C 2 2
MIRT460091 ZYG11B zyg-11 family member B, cell cycle regulator 2 4
MIRT460866 UBE2S ubiquitin conjugating enzyme E2 S 2 2
MIRT461339 NUP133 nucleoporin 133 2 2
MIRT463769 YOD1 YOD1 deubiquitinase 2 2
MIRT466368 THAP1 THAP domain containing 1 2 4
MIRT467168 SPTY2D1 SPT2 chromatin protein domain containing 1 2 2
MIRT468703 SDHD succinate dehydrogenase complex subunit D 2 2
MIRT469122 RNF126 ring finger protein 126 2 2
MIRT472426 NCBP2 nuclear cap binding protein subunit 2 2 4
MIRT479420 CDKN1B cyclin dependent kinase inhibitor 1B 2 8
MIRT484260 FAM177A1 family with sequence similarity 177 member A1 2 2
MIRT485468 IL6ST interleukin 6 signal transducer 2 10
MIRT490237 H2AFZ H2A histone family member Z 2 6
MIRT491002 ATF7IP activating transcription factor 7 interacting protein 2 2
MIRT492127 SUMO2 small ubiquitin-like modifier 2 2 2
MIRT499169 RBPJL recombination signal binding protein for immunoglobulin kappa J region like 2 2
MIRT499825 PCSK9 proprotein convertase subtilisin/kexin type 9 2 8
MIRT501794 NRAS NRAS proto-oncogene, GTPase 2 2
MIRT503441 GINS4 GINS complex subunit 4 2 4
MIRT503688 MAVS mitochondrial antiviral signaling protein 2 5
MIRT506926 IGDCC4 immunoglobulin superfamily DCC subclass member 4 2 6
MIRT511430 HOXA10 homeobox A10 2 6
MIRT512415 LAYN layilin 2 4
MIRT513791 NIPAL3 NIPA like domain containing 3 2 4
MIRT516163 NTMT1 N-terminal Xaa-Pro-Lys N-methyltransferase 1 2 4
MIRT516513 PARK2 parkin RBR E3 ubiquitin protein ligase 2 2
MIRT516915 HINFP histone H4 transcription factor 2 2
MIRT517102 NDUFV3 NADH:ubiquinone oxidoreductase subunit V3 2 2
MIRT517350 NLRP9 NLR family pyrin domain containing 9 2 2
MIRT518019 ABHD15 abhydrolase domain containing 15 2 2
MIRT520945 SRSF10 serine and arginine rich splicing factor 10 2 2
MIRT525250 RNF213 ring finger protein 213 2 2
MIRT530634 PPIC peptidylprolyl isomerase C 2 4
MIRT530671 CHRNB1 cholinergic receptor nicotinic beta 1 subunit 2 4
MIRT531563 ILDR1 immunoglobulin like domain containing receptor 1 2 2
MIRT538205 CYR61 cysteine rich angiogenic inducer 61 2 2
MIRT538419 COLEC10 collectin subfamily member 10 2 2
MIRT541964 ZNF485 zinc finger protein 485 2 2
MIRT543088 KNSTRN kinetochore localized astrin/SPAG5 binding protein 2 2
MIRT543257 ZNF662 zinc finger protein 662 2 2
MIRT543589 KIAA1549 KIAA1549 2 2
MIRT543955 RNF20 ring finger protein 20 2 2
MIRT544043 C9orf64 chromosome 9 open reading frame 64 2 4
MIRT548064 GIGYF1 GRB10 interacting GYF protein 1 2 2
MIRT548240 FBXW7 F-box and WD repeat domain containing 7 2 2
MIRT548442 EIF1AX eukaryotic translation initiation factor 1A, X-linked 2 2
MIRT548623 DAZAP1 DAZ associated protein 1 2 4
MIRT548770 COLEC12 collectin subfamily member 12 2 2
MIRT549506 HDDC2 HD domain containing 2 2 4
MIRT551924 AKAP8 A-kinase anchoring protein 8 2 4
MIRT555656 PGRMC1 progesterone receptor membrane component 1 2 2
MIRT556286 MAP3K5 mitogen-activated protein kinase kinase kinase 5 2 2
MIRT557012 HOXD13 homeobox D13 2 4
MIRT563907 CLSPN claspin 2 2
MIRT565527 SON SON DNA binding protein 2 2
MIRT568000 COMMD2 COMM domain containing 2 2 2
MIRT569831 PLA2G16 phospholipase A2 group XVI 2 4
MIRT573905 PARP1 poly(ADP-ribose) polymerase 1 2 2
MIRT616589 KLHL9 kelch like family member 9 2 2
MIRT617137 ZNF556 zinc finger protein 556 2 2
MIRT617400 API5 apoptosis inhibitor 5 2 2
MIRT617455 CCS copper chaperone for superoxide dismutase 2 2
MIRT617799 ZNF793 zinc finger protein 793 2 2
MIRT618190 MACC1 MACC1, MET transcriptional regulator 2 2
MIRT618303 GNE glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase 2 2
MIRT618329 ZNF813 zinc finger protein 813 2 2
MIRT618820 PHF20 PHD finger protein 20 2 2
MIRT619153 PPDPF pancreatic progenitor cell differentiation and proliferation factor 2 2
MIRT619530 ZNF708 zinc finger protein 708 2 2
MIRT619849 KIR3DX1 killer cell immunoglobulin like receptor, three Ig domains X1 2 2
MIRT620806 SLC26A2 solute carrier family 26 member 2 2 2
MIRT621312 YIPF4 Yip1 domain family member 4 2 2
MIRT621358 GUCA1B guanylate cyclase activator 1B 2 2
MIRT621366 ART4 ADP-ribosyltransferase 4 (Dombrock blood group) 2 2
MIRT621547 ZMYM1 zinc finger MYM-type containing 1 2 2
MIRT621883 TAOK1 TAO kinase 1 2 2
MIRT622451 RNF19B ring finger protein 19B 2 2
MIRT623404 KREMEN1 kringle containing transmembrane protein 1 2 2
MIRT623587 IPO9 importin 9 2 2
MIRT623974 FAM63A MINDY lysine 48 deubiquitinase 1 2 2
MIRT624086 DPP8 dipeptidyl peptidase 8 2 2
MIRT624108 DNAH10OS dynein axonemal heavy chain 10 opposite strand 2 2
MIRT632486 RNF8 ring finger protein 8 2 2
MIRT634057 PLIN3 perilipin 3 2 2
MIRT634657 GDE1 glycerophosphodiester phosphodiesterase 1 2 2
MIRT640682 MCUR1 mitochondrial calcium uniporter regulator 1 2 2
MIRT641242 CENPN centromere protein N 2 2
MIRT642260 ZNF677 zinc finger protein 677 2 2
MIRT642954 RELA RELA proto-oncogene, NF-kB subunit 2 2
MIRT644326 IPP intracisternal A particle-promoted polypeptide 2 2
MIRT644632 ICA1L islet cell autoantigen 1 like 2 2
MIRT645721 POLR3A RNA polymerase III subunit A 2 2
MIRT647850 LYPLA1 lysophospholipase I 2 2
MIRT649281 NEK8 NIMA related kinase 8 2 2
MIRT650038 VHL von Hippel-Lindau tumor suppressor 2 2
MIRT650354 RRP36 ribosomal RNA processing 36 2 2
MIRT651144 ZNF384 zinc finger protein 384 2 2
MIRT651778 UTP6 UTP6, small subunit processome component 2 2
MIRT652576 TLCD2 TLC domain containing 2 2 2
MIRT654621 PTPRJ protein tyrosine phosphatase, receptor type J 2 2
MIRT656023 MYO5A myosin VA 2 2
MIRT656105 MSRB3 methionine sulfoxide reductase B3 2 2
MIRT657749 GMEB1 glucocorticoid modulatory element binding protein 1 2 2
MIRT657924 GATSL2 cytosolic arginine sensor for mTORC1 subunit 2 2 2
MIRT658848 DUSP19 dual specificity phosphatase 19 2 2
MIRT659100 DENND6A DENN domain containing 6A 2 2
MIRT659153 DCX doublecortin 2 2
MIRT660870 ADRBK2 G protein-coupled receptor kinase 3 2 2
MIRT661941 FAHD1 fumarylacetoacetate hydrolase domain containing 1 2 2
MIRT663577 C10orf32 BLOC-1 related complex subunit 7 2 2
MIRT664625 WDPCP WD repeat containing planar cell polarity effector 2 4
MIRT666562 RHOBTB3 Rho related BTB domain containing 3 2 2
MIRT669992 GPR156 G protein-coupled receptor 156 2 4
MIRT670445 RSBN1L round spermatid basic protein 1 like 2 2
MIRT670853 IFNAR1 interferon alpha and beta receptor subunit 1 2 4
MIRT671942 SPPL3 signal peptide peptidase like 3 2 2
MIRT674269 LMOD3 leiomodin 3 2 2
MIRT674424 MIOX myo-inositol oxygenase 2 4
MIRT674982 ATP5G1 ATP synthase, H+ transporting, mitochondrial Fo complex subunit C1 (subunit 9) 2 2
MIRT675038 BACE2 beta-site APP-cleaving enzyme 2 2 4
MIRT675309 C2orf68 chromosome 2 open reading frame 68 2 2
MIRT675641 TTPAL alpha tocopherol transfer protein like 2 2
MIRT688688 CPS1 carbamoyl-phosphate synthase 1 2 2
MIRT689369 ZNF101 zinc finger protein 101 2 2
MIRT689605 AKAP6 A-kinase anchoring protein 6 2 2
MIRT691715 LARS leucyl-tRNA synthetase 2 2
MIRT695473 TRAT1 T-cell receptor associated transmembrane adaptor 1 2 2
MIRT695530 MAP4K2 mitogen-activated protein kinase kinase kinase kinase 2 2 2
MIRT695878 CACNG8 calcium voltage-gated channel auxiliary subunit gamma 8 2 2
MIRT696586 ORMDL2 ORMDL sphingolipid biosynthesis regulator 2 2 2
MIRT703007 HEATR5A HEAT repeat containing 5A 2 2
MIRT707942 PHKA1 phosphorylase kinase regulatory subunit alpha 1 2 2
MIRT709765 GPR183 G protein-coupled receptor 183 2 2
MIRT710332 ZNF669 zinc finger protein 669 2 2
MIRT713249 ZFP30 ZFP30 zinc finger protein 2 2
MIRT716613 RBM18 RNA binding motif protein 18 2 2
MIRT733414 BAG2 BCL2 associated athanogene 2 2 0
MIRT756135 THSD7A thrombospondin type 1 domain containing 7A 3 1
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-1 Anthocyanin NULL 145858 Microarray apoE−/− mice 22253797 2012 down-regulated
miR-1 Caffeic acid NULL 689043 Microarray apoE−/− mice 22253797 2012 down-regulated
miR-1 Catechin approved 9064 Microarray apoE−/− mice 22253797 2012 up-regulated
miR-1 Curcumin NULL 969516 Microarray apoE−/− mice 22253797 2012 down-regulated
miR-1 Ferulic acid NULL 445858 Microarray apoE−/− mice 22253797 2012 down-regulated
miR-1 Hesperidin NULL 10621 Microarray apoE−/− mice 22253797 2012 up-regulated
miR-1 Quercetin NULL 5280343 Microarray apoE−/− mice 22253797 2012 down-regulated
miR-1 Galactose NULL 6036 Quantitative real-time PCR lens 22736950 2012 up-regulated
miR-1 Hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) NULL 8490 Microarray mouse brain 19270793 2009 down-regulated
miR-1 Trichostatin A (TSA) NULL 444732 Quantitative real-time PCR myocardial differentiation of mouse ES cells 19521018 2009 down-regulated
miR-1 Sulfonyl-hydrazone-1 (SHZ) NULL NULL Quantitative real-time PCR Murine broblast-derived Induced pluripotent stem cells 21445862 2011 up-regulated
miR-1 Cocaine NULL 446220 Next-generation sequencing ventral striatum 21708909 2011 up-regulated
miR-1 Atorvastatin approved 60823 Quantitative real-time PCR Cardiomyocyte 23860036 2013 down-regualted
miR-1 Glucose NULL 5793 Quantitative real-time PCR endothelial cells 24394957 2014 down-regulated
miR-1 Docosahexaenoic acid NULL 445580 Quantitative real-time PCR Caco-2 cells 24623846 2014 up-regulated
miR-1 Palmitic acid approved 985 Quantitative real-time PCR Caco-2 cells 24623846 2014 up-regulated
miR-1 17beta-estradiol (E2) approved 5757 Microarray MCF-7AKT breast cancer cells 19528081 2009 down-regulated
miR-1 Essential amino acids (EAA) NULL NULL Quantitative real-time PCR skeletal muscle of young adults 19828686 2009 up-regulated
miR-1 Hydrogen peroxide (H2O2) NULL 784 Quantitative real-time PCR Human umbilical vein endothelial cells 21527937 2011 down-regulated
miR-1 Trichostatin A (TSA) NULL 444732 Microarray apoptosis-resistant breast cancer cells 21971930 2011 up-regulated
miR-1 Arsenic trioxide approved 14888 Quantitative real-time PCR acute promyelocytic leukemia 22072212 2012 up-regulated
miR-1 5-Fluorouracil approved 3385 Microarray CNE cells 22614822 2012 up-regulated
miR-1 Bicalutamide approved 2375 Microarray prostate 22674191 2012 up-regulated
miR-1 Arsenic trioxide approved 14888 Quantitative real-time PCR cardia 22889704 2012 up-regulated
miR-1 Perfluorooctane sulfonate NULL 74483 Microarray zebrafish embryos 20878907 2011 up-regulated
miR-1 Quinidine approved 441074 Quantitative real-time PCR myocardial infarction (MI) rats 19775284 2009 up-regulated
miR-1 Tanshinone IIA NULL 164676 Quantitative real-time PCR myocardial infarction (MI) rats 19775284 2009 down-regulated
miR-1 Tanshinone IIA NULL 164676 Quantitative real-time PCR post-infarction rat cardiomyocytes 21220930 2011 down-regulated
miR-1 Isoproterenol approved 3779 Quantitative real-time PCR heart 22847192 2012 down-regulated
miR-1 Dexamethasone approved 5743 Microarray adrenals and granulosa cells 24205079 2014 up-regulated
miR-1 Thiourea (TU) NULL 737139 Quantitative real-time PCR skeletal muscle and heart 22142802 2012 up-regulated
miR-1 Thiourea (TU) NULL 737139 Quantitative real-time PCR skeletal muscle and heart 22142802 2012 down-regulated
miR-1 Isoproterenol approved 3779 Quantitative real-time PCR heart 22847192 2012 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-1303 Oxaliplatin 6857599 NSC266046 approved sensitive High Colorectal Cancer cell line (RKO)
hsa-miR-1303 Oxaliplatin 6857599 NSC266046 approved resistant High Colorectal Cancer cell line (HT-29)
hsa-miR-1303 Imatinib 5291 NSC743414 approved sensitive High Gastrointestinal Stromal Tumor cell line (882R-NC, 882R-OE, 882R-KD)
hsa-miR-1303 Fulvestrant 17756771 NSC719276 approved sensitive High Breast Cancer cell line (MCF-7)
hsa-miR-1303 Rituximab sensitive High Diffuse Large B-Cell Lymphoma cell line (DB, NU-DHL-1, NU-DUL-1, MC-116, SU-DHL-4, SU-DHL-5, FARAGE, HBL-1, OCI-Ly3, OCI-Ly7, OCI-Ly8, OCI-Ly19, RIVA, SU-DHL-8, U2932)
hsa-miR-1303 Etoposide 36462 NSC141540 approved resistant High Colorectal Cancer cell line (HCT8)
hsa-miR-1303 Doxorubicin 31703 NSC123127 approved resistant High Colorectal Cancer cell line (HCT8)
hsa-miR-1303 Vinorelbine 44424639 approved resistant High Colorectal Cancer cell line (HCT8)
hsa-miR-1303 Vincristine 5978 approved resistant High Colorectal Cancer cell line (HCT8)
hsa-miR-1303 Paclitaxel 36314 NSC125973 approved resistant High Colorectal Cancer cell line (HCT8)
hsa-mir-1303 Dabrafenib 44462760 NSC764134 approved sensitive cell line (A375)
hsa-mir-1303 Cisplatin 5460033 NSC119875 approved resistant cell line (W1)
hsa-mir-1303 Topotecan 60699 NSC609699 approved resistant cell line (W1)
hsa-mir-1303 Androstenedione+Letrozole resistant cell line (MCF-7)
hsa-miR-1303 Gefitinib 123631 NSC715055 approved sensitive cell line (HCC827)
hsa-miR-1303 Osimertinib 71496458 NSC779217 approved sensitive cell line (HCC827)
hsa-miR-1303 Osimertinib 71496458 NSC779217 approved resistant cell line (PC9)
hsa-miR-1303 Vemurafenib 42611257 NSC761431 approved resistant cell line (451Lu)
hsa-miR-1303 Palbociclib 5330286 NSC758247 approved resistant tissue (breast cancer)
hsa-miR-1303 Cisplatin 5460033 NSC119875 approved sensitive cell line
hsa-miR-1303 Gefitinib 123631 NSC715055 approved sensitive cell line (HCC827)
hsa-miR-1303 Paclitaxel 36314 NSC125973 approved resistant cell line (BAS)
hsa-miR-1303 Doxorubicin 31703 NSC123127 approved resistant cell line (HS578T)
hsa-miR-1303 Cisplatin 5460033 NSC119875 approved resistant cell line (CP20)
hsa-miR-1303 Cisplatin 5460033 NSC119875 approved sensitive cell line (MGC-803)
hsa-miR-1303 Oxaliplatin 6857599 NSC266046 approved sensitive cell line (IGROV-1)
hsa-miR-1303 Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)

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