miRTarBase - #MIRT461643


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pre-miRNA Information
pre-miRNA hsa-mir-4436b-1   
Genomic Coordinates chr2: 110086433 - 110086523
Description Homo sapiens miR-4436b-1 stem-loop
Comment None
RNA Secondary Structure
pre-miRNA hsa-mir-4436b-2   
Genomic Coordinates chr2: 110284853 - 110284943
Description Homo sapiens miR-4436b-2 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-4436b-3p
Sequence 60| CAGGGCAGGAAGAAGUGGACAA |81
Evidence Experimental
Experiments Illumina
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs760150076 9 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol ZSWIM4   
Synonyms -
Description zinc finger SWIM-type containing 4
Transcript NM_023072   
Expression
Putative miRNA Targets on ZSWIM4
3'UTR of ZSWIM4
(miRNA target sites are highlighted)		 
>ZSWIM4|NM_023072|3'UTR
   1 GGGACAGTGGGGTGCGTGGGAGTGGGGATCCCCCTCGCCCCTGCGTCCCCCACCCTTGCTCTCCAATTAGGCCCACGTGG
  81 CATTTCAGTATTATTAAGTCAGGGAAGGAGCCCGGCTGGAGATGGGGGCAGGGGGAGCAGCATCCTGCCACGTGTGTGCC
 161 TGGGAGTCTGTGAGCAAGTGTGCAAGACTCCAGAAGCAGAAGCCATACTGCCACCCAGAAGCCTGGAAGGGGTGTGTGCT
 241 TGGGCTGCTGGTATGACCCCACTTTGGGCACCCCAAAAGCAATAGGCAAACTCCCCTTACCCAGACTGGCTTGGGCTCCA
 321 GGAGGGAGGCTGGGAGGCAGGACTTTCCAGAAATCGACCCTCTAAGTCAATGTAGCACATTTTCCCCCAACCCCACCCTG
 401 GGTGGCCAAGGGTCCTCCCCCACCCCCTACTGCTCAGGGCCCCCCATTATGCCACCTCCAAAGTGGCTGCCCAGCCAGGA
 481 CCATTGGCTCACCCCCACTGAAGGAATTGAAGAGGCCTCAGGCCTCAGCCTCATACCTCACCCCCTTATCCTATCCGGCC
 561 AGGACCCCCATTTCCTTGGGCACTAGGGTCCCAGGGTGGGCTCAGGGTTGGGGAAGTCCTCGCTGCCCTCTCTTCTCACC
 641 TGCTAGTCACTGGACGTACAACTCAGGAACTGAGCGAGGCTCACACTGCCCCTTCCAACCTGGGGTTGGGGGACACAGAC
 721 GCGAGAGAGCCGGAGACCCCCACCCCCGATCTGGAAAGGAAAGAGACCTGTATCTTGGTGTTTTTCTGGCTTTTTCACCC
 801 TTTCGCCTCCTGTCTTTCTGCTTCGCCCCTTCATCTTACTCTGTTTCCATTTTTCCCGGCACTTACCTGCCTTTCTCTCT
 881 GCACCTAAGTCCCTGCCGCCCTCTCTCTTTGGCCATCCTTCCTTTCCCCCACCTTGACCCAGGGAGGAGAAGGGAGAACA
 961 TCACCCCCCCAAGTCACCCCCACATCTTTTCCCTTCTTGTATATTAAGGACAAAATACCACATCATTTTGTAACTTTTTT
1041 TCTATTTATTGAACGGTGTATTACATGTCCTTTTCCTTTTTTTTTTTCAAAGATTGAACAGAAATTTTTCTTTTTAATTT
1121 TATTTTGAGACTGGGGTGCATCTCCAGAGCCACTCACACCCTCAACCTCGTTTCCTCCGC
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' aacaggugaAGAAG-GACGGGAc 5'
                   || || ||||||| 
Target 5' ttggggaagTCCTCGCTGCCCTc 3'
 608 - 630 149.00 -15.70
2 
miRNA  3' aacAGGUGAA---------GAA-GGACGGGAc 5'
             ||||:||         ||| ||||||:| 
Target 5' gttTCCATTTTTCCCGGCACTTACCTGCCTTt 3'
 843 - 874 143.00 -17.20
3 
miRNA  3' aacaGGUGAAG-----AAGGACGGGac 5'
              |||| ||     |  ||||||  
Target 5' tatgCCACCTCCAAAGTGGCTGCCCag 3'
 448 - 474 130.00 -15.60
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN20047707 12 COSMIC
COSN30525564 17 COSMIC
COSN30515555 22 COSMIC
COSN28886231 38 COSMIC
COSN27006759 45 COSMIC
COSN30130004 46 COSMIC
COSN30540110 102 COSMIC
COSN30451128 108 COSMIC
COSN30451156 109 COSMIC
COSN30158031 115 COSMIC
COSN31570054 125 COSMIC
COSN31545197 130 COSMIC
COSN24387483 134 COSMIC
COSN1211191 227 COSMIC
COSN1760790 314 COSMIC
COSN28753637 358 COSMIC
COSN21445554 480 COSMIC
COSN31533712 640 COSMIC
COSN30174038 665 COSMIC
COSN28750796 724 COSMIC
COSN8343733 866 COSMIC
COSN21445106 1097 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1485518180 6 dbSNP
rs202197140 9 dbSNP
rs748985554 11 dbSNP
rs144297960 12 dbSNP
rs1182579529 16 dbSNP
rs1031921919 17 dbSNP
rs1380540592 18 dbSNP
rs778919819 26 dbSNP
rs1351433342 29 dbSNP
rs748085568 31 dbSNP
rs201378218 36 dbSNP
rs1362514454 37 dbSNP
rs114355642 38 dbSNP
rs771067856 39 dbSNP
rs1404435222 44 dbSNP
rs374641062 45 dbSNP
rs747778923 46 dbSNP
rs1377967648 53 dbSNP
rs1297664644 56 dbSNP
rs1398166770 58 dbSNP
rs1347487324 59 dbSNP
rs1160418680 74 dbSNP
rs1205542332 78 dbSNP
rs963870200 87 dbSNP
rs1423574645 88 dbSNP
rs1179019045 90 dbSNP
rs1481253509 95 dbSNP
rs995097110 103 dbSNP
rs565116449 113 dbSNP
rs762038108 114 dbSNP
rs769338042 117 dbSNP
rs187360665 126 dbSNP
rs1243310570 128 dbSNP
rs982418028 131 dbSNP
rs1441755793 136 dbSNP
rs1223594247 152 dbSNP
rs1253082629 154 dbSNP
rs1324553488 159 dbSNP
rs1277752099 169 dbSNP
rs1216909483 179 dbSNP
rs767782019 185 dbSNP
rs1161619344 194 dbSNP
rs1364226610 196 dbSNP
rs1438493923 199 dbSNP
rs912202023 203 dbSNP
rs965181859 206 dbSNP
rs975567191 224 dbSNP
rs541355894 233 dbSNP
rs559081432 234 dbSNP
rs1381826168 261 dbSNP
rs967727292 272 dbSNP
rs1429589942 273 dbSNP
rs1169563632 288 dbSNP
rs1426345391 293 dbSNP
rs1421094647 296 dbSNP
rs1472427902 297 dbSNP
rs1241135037 301 dbSNP
rs975145934 308 dbSNP
rs921142103 311 dbSNP
rs773697514 314 dbSNP
rs1159569155 326 dbSNP
rs1257158339 329 dbSNP
rs1197043122 340 dbSNP
rs529642735 341 dbSNP
rs921047923 344 dbSNP
rs761017465 348 dbSNP
rs766908004 354 dbSNP
rs924502757 356 dbSNP
rs987040565 357 dbSNP
rs3745453 358 dbSNP
rs1317724235 360 dbSNP
rs879829683 363 dbSNP
rs563057098 364 dbSNP
rs77843146 371 dbSNP
rs1240008178 385 dbSNP
rs1013035315 386 dbSNP
rs1329709223 395 dbSNP
rs1283391702 399 dbSNP
rs367816771 400 dbSNP
rs1170547350 402 dbSNP
rs1422680586 403 dbSNP
rs1229984669 417 dbSNP
rs1273793867 419 dbSNP
rs1457240783 422 dbSNP
rs762346915 422 dbSNP
rs1196288006 423 dbSNP
rs1239456011 427 dbSNP
rs1438062923 429 dbSNP
rs1186320433 430 dbSNP
rs1368285808 435 dbSNP
rs1471986146 436 dbSNP
rs60965837 440 dbSNP
rs994982409 444 dbSNP
rs1294011973 447 dbSNP
rs765911541 457 dbSNP
rs571847577 461 dbSNP
rs1376804809 462 dbSNP
rs1307537629 464 dbSNP
rs1419257031 470 dbSNP
rs1375105399 471 dbSNP
rs1465558059 472 dbSNP
rs1457068691 475 dbSNP
rs1168687175 488 dbSNP
rs948753282 493 dbSNP
rs1044453380 505 dbSNP
rs372024000 508 dbSNP
rs1164924731 512 dbSNP
rs1425299644 513 dbSNP
rs1392184155 517 dbSNP
rs886722583 520 dbSNP
rs548117320 542 dbSNP
rs534539248 544 dbSNP
rs1009135252 546 dbSNP
rs1190875564 553 dbSNP
rs1032267484 558 dbSNP
rs965409420 559 dbSNP
rs1223232887 579 dbSNP
rs1019806572 593 dbSNP
rs892022511 594 dbSNP
rs1317942876 597 dbSNP
rs968535631 602 dbSNP
rs978593503 606 dbSNP
rs73922778 608 dbSNP
rs1304439048 612 dbSNP
rs1021913415 616 dbSNP
rs934615408 617 dbSNP
rs967697585 622 dbSNP
rs975114941 623 dbSNP
rs1455260162 627 dbSNP
rs1364221927 633 dbSNP
rs1175085460 636 dbSNP
rs1479581323 638 dbSNP
rs555071317 652 dbSNP
rs1028036561 656 dbSNP
rs955117125 657 dbSNP
rs986621900 660 dbSNP
rs1207461213 664 dbSNP
rs576584059 673 dbSNP
rs537585502 675 dbSNP
rs111392178 676 dbSNP
rs374634340 677 dbSNP
rs764744145 685 dbSNP
rs540919614 686 dbSNP
rs1223709875 687 dbSNP
rs1339334806 690 dbSNP
rs1253700081 701 dbSNP
rs1383915934 702 dbSNP
rs74901950 704 dbSNP
rs948722316 711 dbSNP
rs1190599231 713 dbSNP
rs1408611940 720 dbSNP
rs10418969 721 dbSNP
rs60981777 722 dbSNP
rs996885749 723 dbSNP
rs12610873 724 dbSNP
rs530507617 726 dbSNP
rs545926714 731 dbSNP
rs1462607606 732 dbSNP
rs978477143 733 dbSNP
rs533132592 738 dbSNP
rs891944367 740 dbSNP
rs1338334668 747 dbSNP
rs372031025 748 dbSNP
rs1228897764 749 dbSNP
rs1326976221 753 dbSNP
rs1314243218 763 dbSNP
rs1021880953 767 dbSNP
rs1372398939 769 dbSNP
rs955836494 776 dbSNP
rs1406433145 802 dbSNP
rs900757987 805 dbSNP
rs996479998 806 dbSNP
rs191007071 810 dbSNP
rs1279963675 822 dbSNP
rs777277215 825 dbSNP
rs532744585 826 dbSNP
rs1446956054 827 dbSNP
rs1231939207 834 dbSNP
rs1244202210 835 dbSNP
rs1253735563 839 dbSNP
rs1056882 841 dbSNP
rs986938016 855 dbSNP
rs948763573 858 dbSNP
rs757088019 859 dbSNP
rs1211080935 863 dbSNP
rs1162575282 865 dbSNP
rs151124535 865 dbSNP
rs1243760711 869 dbSNP
rs1384903512 880 dbSNP
rs920578448 882 dbSNP
rs1441141137 885 dbSNP
rs566393148 898 dbSNP
rs182491944 899 dbSNP
rs961496857 903 dbSNP
rs973918915 904 dbSNP
rs1047836662 906 dbSNP
rs1161739374 910 dbSNP
rs1427114006 913 dbSNP
rs1386340176 926 dbSNP
rs1056883 932 dbSNP
rs548587070 943 dbSNP
rs1468886884 954 dbSNP
rs1429627848 957 dbSNP
rs373673610 964 dbSNP
rs554631812 964 dbSNP
rs1183600366 966 dbSNP
rs570104287 970 dbSNP
rs1455750278 971 dbSNP
rs1292349753 972 dbSNP
rs367674027 975 dbSNP
rs1348329044 977 dbSNP
rs1359689842 977 dbSNP
rs1281054504 980 dbSNP
rs1240107400 983 dbSNP
rs529165331 986 dbSNP
rs1056884 997 dbSNP
rs1290379623 1001 dbSNP
rs1301383990 1009 dbSNP
rs1406793177 1010 dbSNP
rs969959308 1015 dbSNP
rs1386129854 1019 dbSNP
rs1399441591 1024 dbSNP
rs1298569907 1025 dbSNP
rs1410693371 1035 dbSNP
rs1332250590 1048 dbSNP
rs781309559 1055 dbSNP
rs868288594 1056 dbSNP
rs1196683208 1058 dbSNP
rs1490687091 1061 dbSNP
rs1268944703 1064 dbSNP
rs1309925995 1077 dbSNP
rs996424684 1077 dbSNP
rs1224072707 1078 dbSNP
rs1351014188 1080 dbSNP
rs745754275 1082 dbSNP
rs186816048 1088 dbSNP
rs1214994629 1089 dbSNP
rs1346284136 1090 dbSNP
rs1269661308 1093 dbSNP
rs1429322939 1095 dbSNP
rs1347395883 1097 dbSNP
rs904187710 1100 dbSNP
rs1469570171 1111 dbSNP
rs1404942835 1112 dbSNP
rs1262854044 1116 dbSNP
rs1486489108 1118 dbSNP
rs1209697491 1123 dbSNP
rs1481202801 1128 dbSNP
rs570510334 1131 dbSNP
rs554318919 1137 dbSNP
rs1056887 1138 dbSNP
rs1185359664 1145 dbSNP
rs1474392183 1150 dbSNP
rs1469843634 1151 dbSNP
rs1194315521 1158 dbSNP
rs1243724557 1159 dbSNP
rs1216273275 1162 dbSNP
rs1460735158 1166 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions TZM-bl
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM1462574. RNA binding protein: AGO2. Condition:TZM-bl ami BaL ...

- Whisnant AW; Bogerd HP; Flores O; Ho P; et al., 2013, mBio.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' aacaggugaagaagGACGGGAc 5'
                        ||||||| 
Target 5' --------------CUGCCCUc 3'
 		1 - 8
Article - Whisnant AW; Bogerd HP; Flores O; Ho P; et al.
- mBio, 2013
UNLABELLED: The question of how HIV-1 interfaces with cellular microRNA (miRNA) biogenesis and effector mechanisms has been highly controversial. Here, we first used deep sequencing of small RNAs present in two different infected cell lines (TZM-bl and C8166) and two types of primary human cells (CD4(+) peripheral blood mononuclear cells [PBMCs] and macrophages) to unequivocally demonstrate that HIV-1 does not encode any viral miRNAs. Perhaps surprisingly, we also observed that infection of T cells by HIV-1 has only a modest effect on the expression of cellular miRNAs at early times after infection. Comprehensive analysis of miRNA binding to the HIV-1 genome using the photoactivatable ribonucleoside-induced cross-linking and immunoprecipitation (PAR-CLIP) technique revealed several binding sites for cellular miRNAs, a subset of which were shown to be capable of mediating miRNA-mediated repression of gene expression. However, the main finding from this analysis is that HIV-1 transcripts are largely refractory to miRNA binding, most probably due to extensive viral RNA secondary structure. Together, these data demonstrate that HIV-1 neither encodes viral miRNAs nor strongly influences cellular miRNA expression, at least early after infection, and imply that HIV-1 transcripts have evolved to avoid inhibition by preexisting cellular miRNAs by adopting extensive RNA secondary structures that occlude most potential miRNA binding sites. IMPORTANCE: MicroRNAs (miRNAs) are a ubiquitous class of small regulatory RNAs that serve as posttranscriptional regulators of gene expression. Previous work has suggested that HIV-1 might subvert the function of the cellular miRNA machinery by expressing viral miRNAs or by dramatically altering the level of cellular miRNA expression. Using very sensitive approaches, we now demonstrate that neither of these ideas is in fact correct. Moreover, HIV-1 transcripts appear to largely avoid regulation by cellular miRNAs by adopting an extensive RNA secondary structure that occludes the ability of cellular miRNAs to interact with viral mRNAs. Together, these data suggest that HIV-1, rather than seeking to control miRNA function in infected cells, has instead evolved a mechanism to become largely invisible to cellular miRNA effector mechanisms.
LinkOut: [PMID: 23592263]
CLIP-seq Support 1 for dataset GSM4903825
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / PID14_NS
Location of target site NM_023072 | 3UTR | AGGCCUCAGCCUCAUACCUCACCCCCUUAUCCUAUCCGGCCAGGACCCCCAUUUCCUUGGGCACUAGGGUCCCAGGGUGGGCUCAGGGUUGGGGAAGUCCUCGCUGCCCUCUCUUCUCAC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161237
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM4903826
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / PID21_NS
Location of target site NM_023072 | 3UTR | AGGGUGGGCUCAGGGUUGGGGAAGUCCUCGCUGCCCUCUCUUCUCAC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161237
CLIP-seq Viewer Link
CLIP-seq Support 3 for dataset GSM4903827
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / PID14_9124
Location of target site NM_023072 | 3UTR | AGGGUGGGCUCAGGGUUGGGGAAGUCCUCGCUGCCCUCUCUUCUCAC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161237
CLIP-seq Viewer Link
CLIP-seq Support 4 for dataset GSM4903833
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / CTL_TD_21_a
Location of target site NM_023072 | 3UTR | UCCUCGCUGCCCUCUCUUCUCAC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 5 for dataset GSM1462574
Method / RBP PAR-CLIP / AGO2
Cell line / Condition TZM-bl / TZM-bl ami BaL
Location of target site ENST00000254323.2 | 3UTR | CUGCCCUCUCUUCUCACCUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23592263 / GSE59944
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
87 hsa-miR-4436b-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT066957 ATXN7L3B ataxin 7 like 3B 2 8
MIRT119284 NABP1 nucleic acid binding protein 1 2 6
MIRT128915 KMT2A lysine methyltransferase 2A 2 2
MIRT150116 MIDN midnolin 2 2
MIRT173040 YTHDF3 YTH N6-methyladenosine RNA binding protein 3 2 2
MIRT253117 BCL2L12 BCL2 like 12 2 2
MIRT256997 RGMB repulsive guidance molecule family member b 2 2
MIRT259746 SNX12 sorting nexin 12 2 2
MIRT267278 TMEM109 transmembrane protein 109 2 2
MIRT441934 C1orf109 chromosome 1 open reading frame 109 2 2
MIRT443625 CPSF2 cleavage and polyadenylation specific factor 2 2 2
MIRT445757 AGO1 argonaute 1, RISC catalytic component 2 2
MIRT447835 CTIF cap binding complex dependent translation initiation factor 2 2
MIRT451230 ZNF444 zinc finger protein 444 2 2
MIRT451966 TMPRSS5 transmembrane protease, serine 5 2 2
MIRT453127 HOXC4 homeobox C4 2 2
MIRT454604 RPL13A ribosomal protein L13a 2 2
MIRT455176 SUV39H1 suppressor of variegation 3-9 homolog 1 2 2
MIRT455547 GJB1 gap junction protein beta 1 2 2
MIRT458197 ATP6V0A2 ATPase H+ transporting V0 subunit a2 2 2
MIRT458356 NOC2L NOC2 like nucleolar associated transcriptional repressor 2 2
MIRT458923 DNM2 dynamin 2 2 2
MIRT461013 SYT7 synaptotagmin 7 2 2
MIRT461643 ZSWIM4 zinc finger SWIM-type containing 4 2 2
MIRT461997 PACSIN1 protein kinase C and casein kinase substrate in neurons 1 2 2
MIRT462367 BCL7B BCL tumor suppressor 7B 2 2
MIRT464915 TXNIP thioredoxin interacting protein 2 2
MIRT466311 TIMM22 translocase of inner mitochondrial membrane 22 2 2
MIRT466591 TBC1D2B TBC1 domain family member 2B 2 2
MIRT467045 SRSF1 serine and arginine rich splicing factor 1 2 2
MIRT468750 SDC2 syndecan 2 2 2
MIRT468943 RPS24 ribosomal protein S24 2 2
MIRT469474 REEP5 receptor accessory protein 5 2 2
MIRT469913 PTRF caveolae associated protein 1 2 2
MIRT473325 MEX3A mex-3 RNA binding family member A 2 2
MIRT473643 MARK2 microtubule affinity regulating kinase 2 2 2
MIRT474064 LMNB2 lamin B2 2 2
MIRT474357 KMT2D lysine methyltransferase 2D 2 2
MIRT475394 ICMT isoprenylcysteine carboxyl methyltransferase 2 4
MIRT476335 GLTSCR1L BRD4 interacting chromatin remodeling complex associated protein like 2 2
MIRT478651 CTDNEP1 CTD nuclear envelope phosphatase 1 2 2
MIRT479585 CDC42SE1 CDC42 small effector 1 2 2
MIRT479943 CBX5 chromobox 5 2 2
MIRT482001 AMOTL2 angiomotin like 2 2 2
MIRT482043 AMER1 APC membrane recruitment protein 1 2 2
MIRT483070 EXT2 exostosin glycosyltransferase 2 2 6
MIRT484323 KCNH1 potassium voltage-gated channel subfamily H member 1 2 4
MIRT487528 GXYLT2 glucoside xylosyltransferase 2 2 2
MIRT489636 ALS2CL ALS2 C-terminal like 2 2
MIRT490693 SSTR1 somatostatin receptor 1 2 2
MIRT490871 UPK2 uroplakin 2 2 2
MIRT492582 PPM1L protein phosphatase, Mg2+/Mn2+ dependent 1L 2 2
MIRT492945 NEUROD2 neuronal differentiation 2 2 2
MIRT498675 SOD2 superoxide dismutase 2 2 4
MIRT499349 RAB25 RAB25, member RAS oncogene family 2 2
MIRT502338 GIGYF1 GRB10 interacting GYF protein 1 2 4
MIRT502976 CCNL1 cyclin L1 2 8
MIRT503706 NUP62 nucleoporin 62 2 2
MIRT505567 SMUG1 single-strand-selective monofunctional uracil-DNA glycosylase 1 2 2
MIRT507808 CDKN1B cyclin dependent kinase inhibitor 1B 2 2
MIRT513242 FBXO41 F-box protein 41 2 6
MIRT513586 EVX1 even-skipped homeobox 1 2 2
MIRT525036 FRK fyn related Src family tyrosine kinase 2 2
MIRT531035 TDGF1P3 teratocarcinoma-derived growth factor 1 pseudogene 3 2 2
MIRT531939 RBMS2 RNA binding motif single stranded interacting protein 2 2 2
MIRT534912 PUM2 pumilio RNA binding family member 2 2 2
MIRT535717 N4BP1 NEDD4 binding protein 1 2 2
MIRT540498 ZMAT4 zinc finger matrin-type 4 2 4
MIRT541465 AURKA aurora kinase A 2 2
MIRT554328 SH3GLB1 SH3 domain containing GRB2 like, endophilin B1 2 2
MIRT561572 SLC6A9 solute carrier family 6 member 9 2 2
MIRT564715 ZNF322P1 zinc finger protein 322 pseudogene 1 2 2
MIRT576176 Hmox1 heme oxygenase 1 2 2
MIRT629712 XKR4 XK related 4 2 2
MIRT636182 THBD thrombomodulin 2 2
MIRT646315 MPHOSPH8 M-phase phosphoprotein 8 2 2
MIRT649174 IQSEC1 IQ motif and Sec7 domain 1 2 2
MIRT666945 PMEPA1 prostate transmembrane protein, androgen induced 1 2 2
MIRT684057 FOLR1 folate receptor 1 2 2
MIRT687585 MAU2 MAU2 sister chromatid cohesion factor 2 2
MIRT689953 ZNF185 zinc finger protein 185 with LIM domain 2 2
MIRT704071 SRCAP Snf2 related CREBBP activator protein 2 2
MIRT704327 DCUN1D5 defective in cullin neddylation 1 domain containing 5 2 2
MIRT705406 ATP1B3 ATPase Na+/K+ transporting subunit beta 3 2 2
MIRT710488 CDH5 cadherin 5 2 2
MIRT718241 LCE1A late cornified envelope 1A 2 2
MIRT723182 CDCA4 cell division cycle associated 4 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-4436b-3p Gefitinib 123631 NSC715055 approved resistant cell line (HCC827)
hsa-miR-4436b-3p Gemcitabine 60750 NSC613327 approved resistant cell line (Panc1-GR4)

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