miRTarBase - #MIRT461653


—
pre-miRNA Information
pre-miRNA hsa-mir-3650   
Genomic Coordinates chr5: 38557502 - 38557561
Description Homo sapiens miR-3650 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-3650
Sequence 4| AGGUGUGUCUGUAGAGUCC |22
Evidence Experimental
Experiments 454
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol G6PC   
Synonyms G6PC1, G6PT, G6Pase, GSD1, GSD1a
Description glucose-6-phosphatase catalytic subunit
Transcript NM_000151   
Expression
Putative miRNA Targets on G6PC
3'UTR of G6PC
(miRNA target sites are highlighted)		 
>G6PC|NM_000151|3'UTR
   1 GAGATGTGGAGTCTTCGGTGTTTAAAGTCAACAACCATGCCAGGGATTGAGGAGGACTACTATTTGAAGCAATGGGCACT
  81 GGTATTTGGAGCAAGTGACATGCCATCCATTCTGCCGTCGTGGAATTAAATCACGGATGGCAGATTGGAGGGTCGCCTGG
 161 CTTATTCCCATGTGTGACTCCAGCCTGCCCTCAGCACAGACTCTTTCAGATGGAGGTGCCATATCACGTACACCATATGC
 241 AAGTTTCCCGCCAGGAGGTCCTCCTCTCTCTACTTGAATACTCTCACAAGTAGGGAGCTCACTCCCACTGGAACAGCCCA
 321 TTTTATCTTTGAATGGTCTTCTGCCAGCCCATTTTGAGGCCAGAGGTGCTGTCAGCTCAGGTGGTCCTCTTTTACAATCC
 401 TAATCATATTGGGTAATGTTTTTGAAAAGCTAATGAAGCTATTGAGAAAGACCTGTTGCTAGAAGTTGGGTTGTTCTGGA
 481 TTTTCCCCTGAAGACTTACTTATTCTTCCGTCACATATACAAAAGCAAGACTTCCAGGTAGGGCCAGCTCACAAGCCCAG
 561 GCTGGAGATCCTAACTGAGAATTTTCTACCTGTGTTCATTCTTACCGAGAAAAGGAGAAAGGAGCTCTGAATCTGATAGG
 641 AAAAGAAGGCTGCCTAAGGAGGAGTTTTTAGTATGTGGCGTATCATGCAAGTGCTATGCCAAGCCATGTCTAAATGGCTT
 721 TAATTATATAGTAATGCACTCTCAGTAATGGGGGACCAGCTTAAGTATAATTAATAGATGGTTAGTGGGGTAATTCTGCT
 801 TCTAGTATTTTTTTTACTGTGCATACATGTTCATCGTATTTCCTTGGATTTCTGAATGGCTGCAGTGACCCAGATATTGC
 881 ACTAGGTCAAAACATTCAGGTATAGCTGACATCTCCTCTATCACATTACATCATCCTCCTTATAAGCCCAGCTCTGCTTT
 961 TTCCAGATTCTTCCACTGGCTCCACATCCACCCCACTGGATCTTCAGAAGGCTAGAGGGCGACTCTGGTGGTGCTTTTGT
1041 ATGTTTCAATTAGGCTCTGAAATCTTGGGCAAAATGACAAGGGGAGGGCCAGGATTCCTCTCTCAGGTCACTCCAGTGTT
1121 ACTTTTAATTCCTAGAGGGTAAATATGACTCCTTTCTCTATCCCAAGCCAACCAAGAGCACATTCTTAAAGGAAAAGTCA
1201 ACATCTTCTCTCTTTTTTTTTTTTTTTGAGACAGGGTCTCACTATGTTGCCCAGGCTGCTCTTGAATTCCTGGGCTCAAG
1281 CAGTCCTCCCACCCTACCACAGCGTCCCGCGTAGCTGGGACTACAGGTGCAAGCCACTATGTCCAGCTAGCCAACTCCTC
1361 CTTGCCTGCTTTTCTTTTTTTTTCTTTTTTTGAGACGGCGCACCTATCACCCAGGCTGGAGTGGAGTGGCACGATCTTGG
1441 CTCACTGCAACCTCTTCCTCCTGGTTCAAGCGATTCTCATGTCTCAGCCTCCTCAGTAGCTAGGACTACCGGCGTGCACC
1521 ACCATGCCAGGCTAATTTTTATATTTTTAGAATTTTAGAAGAGATGGGATTTCATCATGTTGGCCAGGCTGGTCTCGAAC
1601 TCCTGACCTCAAGTGATCCACCTGCCTTGGCCTCCCAAGGTGCTAGGATTACAGGCATGAGCCACCGCACCGGGCCCTCC
1681 TTGCCTGTTTTTCAATCTCATCTGATATGCAGAGTATTTCTGCCCCACCCACCTACCCCCCAAAAAAAGCTGAAGCCTAT
1761 TTATTTGAAAGTCCTTGTTTTTGCTACTAATTATATAGTATACCATACATTATCATTCAAAACAACCATCCTGCTCATAA
1841 CATCTTTGAAAAGAAAAATATATATGTGCAGTATTTTATTAAAGCAACATTTTATTTAAGAATAAAGTCTTGTTAATTAC
1921 TATATTTTAGATGCAATGTGATCTGAAGTTTCTAATTCTGGCCCAACTAAATTTCTAGCTCTGTTTCCCTAAACAAATAA
2001 TTTGGTTTCTCTGTGCCTGCATTTTCCCTTTGGAGAAGAAAAGTGCTCTCTCTTGAGTTGACCGAGAGTCCCATTAGGGA
2081 TAGGGAGACTTAAATGCATCCACAGGGGCACAGGCAGAGTTGAGCACATAAACGGAGGCCCAAAATCAGCATAGAACCAG
2161 AAAGATTCAGAGTTGGCCAAGAATGAACATTGGCTACCAGACCACAAGTCAGCATGAGTTGCTCTATGGCATCAAATTGC
2241 AACTTGAGAGTAGATGGGCAGGGTCACTATCAAATTAAGCAATCAGGGCACACAAGTTGCAGTAACACAACAAGACTAGG
2321 CCAGCTCTGGAATCCAGTAACTCAGTGTCAGCAAGGTTTTGGGTTATAGTTCAAGAAAGTCTAAACAGAGCCAGTCACAG
2401 CACCAAGGAATGCTCAAGGGAGCTATTGCAGGTTTCTCTGCTAAGAGATTTATTTCATCCTGGGTGCAGGGTTCGACCTC
2481 CAAAGGCCTCAAATCATCACCGTATCAATGGATTTCCTGAGGGTAAGCTCCGCTATTTCACACCTGAACTCCGGAGTCTG
2561 TATATTCAGGGAAGATTGCATTCTCCTACTGGATTTGGGCTCTCAGAGGGCGTTGTGGGAACCAGGCCCCTCACAGAATC
2641 AAATGGTCCCAACCAGGGAGAAAGAAAATAGTCTTTTTTTTTTTTTTAATAGAGATGGGGGTCTCACTATGCTGCCCAGG
2721 CTGGTCTTGAACTCCTGGGTTCAAGTGATCCTCCTGCCTCAGCCTCCCAAAGTGCTGGGATTACAGTGTGAGCCACTGCG
2801 CTTGGCCAGAAATGGTTTTGATCTGTCTGAACTGAACCCTACTGCTTAGGCATAGCCCCATCCTTGATAATCTATTTGCT
2881 CCCAAGGACCAAGTCCAAGATCCTTACAAGAAAGGTCTGCCAGAAAGTAAATACTGCCCCCACTCCCTGAAGTTTATGAG
2961 GTTGATAAGAAAACATAACAGATAAAGTTTATTGAGTGCTAACTTTAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' ccugaGAUGUC--UGUGUGGa 5'
               :|:|||  ||||| | 
Target 5' acaagTTGCAGTAACACAACa 3'
 2292 - 2312 120.00 -9.42
2 
miRNA  3' ccugagaugucuGUGUGGa 5'
                      |||||| 
Target 5' gctccgctatttCACACCt 3'
 2527 - 2545 120.00 -13.40
3 
miRNA  3' ccugagAU-GUCUGUGUGGa 5'
                || || ::||||| 
Target 5' gtgccaTATCACGTACACCa 3'
 216 - 235 117.00 -7.70
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
212778 4 ClinVar
889515 18 ClinVar
255350 24 ClinVar
323365 25 ClinVar
889516 104 ClinVar
323366 120 ClinVar
323367 121 ClinVar
323368 212 ClinVar
890174 251 ClinVar
890175 252 ClinVar
323369 287 ClinVar
323370 493 ClinVar
323371 557 ClinVar
323372 608 ClinVar
890176 681 ClinVar
323373 704 ClinVar
323374 715 ClinVar
323375 728 ClinVar
323376 746 ClinVar
323377 878 ClinVar
890758 888 ClinVar
323378 987 ClinVar
323379 1013 ClinVar
323380 1040 ClinVar
323381 1211 ClinVar
323382 1213 ClinVar
323383 1295 ClinVar
323384 1305 ClinVar
891991 1312 ClinVar
323385 1314 ClinVar
323386 1325 ClinVar
891992 1401 ClinVar
323387 1455 ClinVar
889572 1459 ClinVar
889573 1467 ClinVar
323388 1514 ClinVar
889574 1515 ClinVar
889575 1528 ClinVar
323389 1545 ClinVar
889576 1551 ClinVar
323390 1553 ClinVar
889577 1641 ClinVar
323391 1653 ClinVar
890228 1672 ClinVar
890229 1902 ClinVar
323392 1971 ClinVar
323393 1982 ClinVar
323394 1987 ClinVar
890230 2082 ClinVar
323395 2089 ClinVar
323396 2096 ClinVar
323397 2134 ClinVar
323398 2135 ClinVar
890794 2185 ClinVar
323399 2312 ClinVar
890795 2419 ClinVar
890796 2475 ClinVar
323400 2502 ClinVar
323401 2520 ClinVar
323402 2533 ClinVar
323403 2612 ClinVar
323404 2674 ClinVar
892038 2724 ClinVar
323405 2801 ClinVar
323406 2848 ClinVar
892039 2858 ClinVar
888571 2976 ClinVar
888572 2981 ClinVar
323407 2982 ClinVar
COSN30457812 2 COSMIC
COSN13723443 17 COSMIC
COSN30530794 17 COSMIC
COSN30506512 20 COSMIC
COSN15661244 24 COSMIC
COSN31599508 54 COSMIC
COSN31597209 60 COSMIC
COSN31614015 77 COSMIC
COSN31518938 100 COSMIC
COSN18740678 101 COSMIC
COSN30485795 108 COSMIC
COSN28749344 109 COSMIC
COSN30112356 116 COSMIC
COSN30508633 136 COSMIC
COSN30107740 171 COSMIC
COSN29223845 237 COSMIC
COSN15829827 502 COSMIC
COSN29659214 816 COSMIC
COSN16449288 828 COSMIC
COSN17423720 1029 COSMIC
COSN23862660 1114 COSMIC
COSN20113957 1228 COSMIC
COSN1196996 1229 COSMIC
COSN17838026 1305 COSMIC
COSN17882198 1320 COSMIC
COSN15863770 1433 COSMIC
COSN15085993 1684 COSMIC
COSN20907449 1700 COSMIC
COSN22445510 1809 COSMIC
COSN16274547 1870 COSMIC
COSN17290331 1910 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1398370649 2 dbSNP
rs191399793 4 dbSNP
rs566247950 10 dbSNP
rs1369980935 11 dbSNP
rs775267643 12 dbSNP
rs762140129 14 dbSNP
rs767908090 17 dbSNP
rs34537381 18 dbSNP
rs1241099625 19 dbSNP
rs2229611 24 dbSNP
rs377739870 25 dbSNP
rs372909414 27 dbSNP
rs1273525090 30 dbSNP
rs755143616 33 dbSNP
rs765355094 35 dbSNP
rs1256766238 36 dbSNP
rs753012050 37 dbSNP
rs758232327 38 dbSNP
rs1212238430 45 dbSNP
rs537055293 46 dbSNP
rs775240201 49 dbSNP
rs746889750 53 dbSNP
rs1455092796 65 dbSNP
rs1172503341 71 dbSNP
rs761973914 74 dbSNP
rs184246813 83 dbSNP
rs1001961594 96 dbSNP
rs1447790159 102 dbSNP
rs577036654 103 dbSNP
rs1032152255 104 dbSNP
rs1464728696 105 dbSNP
rs957762177 117 dbSNP
rs987892731 118 dbSNP
rs886052957 120 dbSNP
rs150477898 121 dbSNP
rs1182684573 135 dbSNP
rs138332426 136 dbSNP
rs1234207596 138 dbSNP
rs1202045165 139 dbSNP
rs1436693611 142 dbSNP
rs903334977 155 dbSNP
rs1314970749 156 dbSNP
rs1413343029 156 dbSNP
rs910765808 160 dbSNP
rs867584902 166 dbSNP
rs1280424998 171 dbSNP
rs1296624306 172 dbSNP
rs1008371805 173 dbSNP
rs1019808706 175 dbSNP
rs1318875952 181 dbSNP
rs1305110920 184 dbSNP
rs964292539 191 dbSNP
rs1256300514 198 dbSNP
rs1347188614 202 dbSNP
rs367967732 210 dbSNP
rs886052958 212 dbSNP
rs1175097478 217 dbSNP
rs1469361441 225 dbSNP
rs952489742 228 dbSNP
rs1223983484 229 dbSNP
rs1489645722 232 dbSNP
rs1291624214 243 dbSNP
rs973539002 250 dbSNP
rs143802152 251 dbSNP
rs753206089 252 dbSNP
rs929482911 254 dbSNP
rs765390240 257 dbSNP
rs1305389945 258 dbSNP
rs1195596560 259 dbSNP
rs1223429374 264 dbSNP
rs1368497494 268 dbSNP
rs1285449267 277 dbSNP
rs886052959 287 dbSNP
rs541803451 288 dbSNP
rs1403129234 298 dbSNP
rs970530104 303 dbSNP
rs1302439367 305 dbSNP
rs563588003 311 dbSNP
rs1454294477 312 dbSNP
rs371213492 317 dbSNP
rs1346730240 319 dbSNP
rs1263551714 335 dbSNP
rs1477331388 338 dbSNP
rs1168080751 346 dbSNP
rs1201156001 356 dbSNP
rs1479145406 363 dbSNP
rs750508510 368 dbSNP
rs530674636 369 dbSNP
rs1187588617 372 dbSNP
rs1487177186 375 dbSNP
rs1466080239 388 dbSNP
rs1215449031 390 dbSNP
rs543413807 392 dbSNP
rs758748813 396 dbSNP
rs895921511 400 dbSNP
rs1221957800 401 dbSNP
rs950075458 408 dbSNP
rs1044792089 428 dbSNP
rs564906976 450 dbSNP
rs1002097557 459 dbSNP
rs1278982668 469 dbSNP
rs1382704690 482 dbSNP
rs532485841 493 dbSNP
rs1363904191 494 dbSNP
rs981970081 504 dbSNP
rs1341504997 510 dbSNP
rs547464411 511 dbSNP
rs1406579351 527 dbSNP
rs937952224 528 dbSNP
rs893629138 529 dbSNP
rs1009849048 540 dbSNP
rs1333011223 541 dbSNP
rs1467950089 548 dbSNP
rs1234083914 551 dbSNP
rs1255430885 554 dbSNP
rs533491939 557 dbSNP
rs1260203648 571 dbSNP
rs914545441 571 dbSNP
rs1186478427 576 dbSNP
rs1462023370 590 dbSNP
rs1218703513 591 dbSNP
rs750061113 593 dbSNP
rs954617725 601 dbSNP
rs755684225 604 dbSNP
rs1201997175 605 dbSNP
rs947388396 607 dbSNP
rs886052960 608 dbSNP
rs146600876 618 dbSNP
rs1008529838 640 dbSNP
rs1191119853 649 dbSNP
rs758483700 659 dbSNP
rs1269043906 660 dbSNP
rs1305860138 662 dbSNP
rs530307111 666 dbSNP
rs1293298575 673 dbSNP
rs1017294910 674 dbSNP
rs964935345 676 dbSNP
rs1383226646 678 dbSNP
rs1338522487 679 dbSNP
rs1041783258 680 dbSNP
rs973632286 681 dbSNP
rs779780631 684 dbSNP
rs950852305 686 dbSNP
rs748752168 688 dbSNP
rs1041232911 695 dbSNP
rs1387471321 696 dbSNP
rs375295552 704 dbSNP
rs139091543 705 dbSNP
rs1160947532 707 dbSNP
rs754543282 713 dbSNP
rs886052961 715 dbSNP
rs80193931 728 dbSNP
rs1287437492 730 dbSNP
rs1227553043 739 dbSNP
rs1360153699 741 dbSNP
rs1393164721 744 dbSNP
rs116897758 746 dbSNP
rs1339692663 768 dbSNP
rs1329082512 769 dbSNP
rs1392822798 775 dbSNP
rs1300758054 776 dbSNP
rs1297171877 797 dbSNP
rs552220012 798 dbSNP
rs1424748732 800 dbSNP
rs1015330191 808 dbSNP
rs936033810 808 dbSNP
rs970498839 808 dbSNP
rs1053624013 814 dbSNP
rs1368862651 816 dbSNP
rs570444384 818 dbSNP
rs1364775057 819 dbSNP
rs981937619 827 dbSNP
rs1417614465 828 dbSNP
rs149299573 830 dbSNP
rs1223246044 835 dbSNP
rs1309855475 836 dbSNP
rs72826982 878 dbSNP
rs959201611 879 dbSNP
rs1355349601 886 dbSNP
rs1279982991 887 dbSNP
rs777466548 890 dbSNP
rs746849569 891 dbSNP
rs754827320 894 dbSNP
rs1042622036 898 dbSNP
rs1333558844 912 dbSNP
rs890182205 914 dbSNP
rs1442601255 915 dbSNP
rs574584322 931 dbSNP
rs766279304 946 dbSNP
rs1404974855 979 dbSNP
rs1346878043 980 dbSNP
rs370935410 987 dbSNP
rs1488639762 988 dbSNP
rs947393062 992 dbSNP
rs1017388299 996 dbSNP
rs1208855117 999 dbSNP
rs1452086734 1005 dbSNP
rs537108675 1012 dbSNP
rs75063448 1013 dbSNP
rs1481442101 1015 dbSNP
rs944084696 1019 dbSNP
rs776851181 1021 dbSNP
rs994536456 1022 dbSNP
rs1284879909 1028 dbSNP
rs1178671294 1029 dbSNP
rs1381500845 1030 dbSNP
rs529429768 1031 dbSNP
rs549474805 1040 dbSNP
rs983602613 1044 dbSNP
rs1048622043 1048 dbSNP
rs917426226 1052 dbSNP
rs556830972 1054 dbSNP
rs1458659092 1060 dbSNP
rs1293139885 1074 dbSNP
rs971614652 1085 dbSNP
rs980145615 1086 dbSNP
rs1392430430 1089 dbSNP
rs1436380632 1092 dbSNP
rs927418828 1097 dbSNP
rs936001112 1103 dbSNP
rs1320881597 1104 dbSNP
rs1380848188 1108 dbSNP
rs1365320494 1110 dbSNP
rs1177391290 1117 dbSNP
rs575186130 1127 dbSNP
rs1015306638 1135 dbSNP
rs915127199 1149 dbSNP
rs945300183 1153 dbSNP
rs1475791681 1162 dbSNP
rs1242578838 1170 dbSNP
rs1195272652 1183 dbSNP
rs1376063925 1188 dbSNP
rs1445032851 1204 dbSNP
rs545658086 1206 dbSNP
rs201313100 1207 dbSNP
rs1314676553 1209 dbSNP
rs1220520404 1210 dbSNP
rs1325324641 1211 dbSNP
rs144568330 1211 dbSNP
rs1260869436 1212 dbSNP
rs1272403018 1213 dbSNP
rs1449862177 1213 dbSNP
rs1465364923 1213 dbSNP
rs1491174689 1213 dbSNP
rs11436510 1214 dbSNP
rs200704026 1215 dbSNP
rs1270918195 1216 dbSNP
rs1033442792 1221 dbSNP
rs1333778984 1223 dbSNP
rs397735497 1228 dbSNP
rs1198743417 1229 dbSNP
rs1236963026 1230 dbSNP
rs959212634 1233 dbSNP
rs1447643965 1234 dbSNP
rs1480631301 1235 dbSNP
rs1183897977 1245 dbSNP
rs1175977779 1246 dbSNP
rs1416476417 1251 dbSNP
rs1424732990 1273 dbSNP
rs989746795 1274 dbSNP
rs890265916 1276 dbSNP
rs1008760378 1291 dbSNP
rs161620 1295 dbSNP
rs559807250 1298 dbSNP
rs1399621224 1304 dbSNP
rs549833149 1305 dbSNP
rs994462869 1309 dbSNP
rs1027330315 1310 dbSNP
rs1379753312 1311 dbSNP
rs1395262885 1312 dbSNP
rs886052962 1314 dbSNP
rs1005529625 1320 dbSNP
rs548787621 1325 dbSNP
rs971966934 1327 dbSNP
rs934332561 1331 dbSNP
rs976779865 1338 dbSNP
rs980278332 1339 dbSNP
rs921369844 1342 dbSNP
rs1034358441 1354 dbSNP
rs932822722 1355 dbSNP
rs957460607 1366 dbSNP
rs1180911937 1375 dbSNP
rs1305237704 1375 dbSNP
rs1446198935 1375 dbSNP
rs1470346991 1376 dbSNP
rs888701395 1380 dbSNP
rs1203087053 1385 dbSNP
rs990081454 1397 dbSNP
rs1482456838 1398 dbSNP
rs1293084158 1400 dbSNP
rs113536060 1401 dbSNP
rs946091500 1405 dbSNP
rs1289682396 1414 dbSNP
rs1483839185 1419 dbSNP
rs1224536750 1422 dbSNP
rs1375714768 1423 dbSNP
rs1187680391 1424 dbSNP
rs763493186 1434 dbSNP
rs1255838476 1437 dbSNP
rs1303666184 1447 dbSNP
rs1478956503 1454 dbSNP
rs148453821 1455 dbSNP
rs944532944 1472 dbSNP
rs572871169 1473 dbSNP
rs552879065 1490 dbSNP
rs1054862308 1511 dbSNP
rs558231884 1512 dbSNP
rs374021788 1514 dbSNP
rs111309126 1515 dbSNP
rs1202205741 1517 dbSNP
rs1465424785 1524 dbSNP
rs966575521 1528 dbSNP
rs886093149 1535 dbSNP
rs534589177 1542 dbSNP
rs1384184340 1545 dbSNP
rs397717945 1545 dbSNP
rs1324359967 1551 dbSNP
rs138968865 1553 dbSNP
rs201722515 1554 dbSNP
rs1403187321 1558 dbSNP
rs1400281076 1565 dbSNP
rs1024977369 1574 dbSNP
rs1292893014 1580 dbSNP
rs1277150496 1583 dbSNP
rs1346785353 1589 dbSNP
rs907455211 1598 dbSNP
rs537388227 1606 dbSNP
rs1001624548 1609 dbSNP
rs1429371159 1614 dbSNP
rs1034494396 1617 dbSNP
rs976750374 1621 dbSNP
rs957429317 1629 dbSNP
rs556943624 1641 dbSNP
rs1020395572 1643 dbSNP
rs765883953 1653 dbSNP
rs1246639251 1656 dbSNP
rs546236128 1658 dbSNP
rs7210335 1665 dbSNP
rs940217664 1667 dbSNP
rs1210777847 1668 dbSNP
rs568149292 1672 dbSNP
rs911757369 1673 dbSNP
rs944611985 1675 dbSNP
rs377751565 1676 dbSNP
rs921779184 1678 dbSNP
rs930493904 1683 dbSNP
rs1037263079 1696 dbSNP
rs1434090610 1706 dbSNP
rs928224894 1712 dbSNP
rs938988165 1713 dbSNP
rs1464068412 1715 dbSNP
rs1376613405 1727 dbSNP
rs1171719517 1731 dbSNP
rs1188263806 1736 dbSNP
rs1388864234 1736 dbSNP
rs1430877397 1736 dbSNP
rs1049280736 1738 dbSNP
rs1245160564 1742 dbSNP
rs571386177 1743 dbSNP
rs1425955819 1750 dbSNP
rs1482952840 1756 dbSNP
rs1205125708 1760 dbSNP
rs1252021860 1760 dbSNP
rs894894773 1766 dbSNP
rs1011034909 1768 dbSNP
rs1043495928 1775 dbSNP
rs1171660697 1776 dbSNP
rs1316679881 1786 dbSNP
rs1393986100 1787 dbSNP
rs902319148 1795 dbSNP
rs367885331 1796 dbSNP
rs999336688 1803 dbSNP
rs1369200395 1810 dbSNP
rs1168551238 1828 dbSNP
rs1420115005 1829 dbSNP
rs1387530263 1830 dbSNP
rs940311557 1837 dbSNP
rs1423524327 1843 dbSNP
rs1297304578 1851 dbSNP
rs575079591 1864 dbSNP
rs775865016 1868 dbSNP
rs1178964281 1874 dbSNP
rs1482127386 1876 dbSNP
rs1438157888 1888 dbSNP
rs1272337864 1889 dbSNP
rs1204394514 1890 dbSNP
rs1018801972 1891 dbSNP
rs1045409943 1904 dbSNP
rs539395778 1912 dbSNP
rs1001760517 1924 dbSNP
rs1339454498 1926 dbSNP
rs1307290740 1928 dbSNP
rs370221388 1938 dbSNP
rs754518597 1968 dbSNP
rs192778595 1971 dbSNP
rs1307938508 1979 dbSNP
rs573802724 1982 dbSNP
rs984583449 1985 dbSNP
rs542411157 1987 dbSNP
rs1457727700 1998 dbSNP
rs1356407111 2012 dbSNP
rs1008609077 2018 dbSNP
rs1217823743 2021 dbSNP
rs1283919859 2024 dbSNP
rs1019623243 2027 dbSNP
rs965927045 2028 dbSNP
rs1471632309 2029 dbSNP
rs1445564238 2049 dbSNP
rs1181360771 2050 dbSNP
rs758226811 2064 dbSNP
rs1269391905 2065 dbSNP
rs9902963 2089 dbSNP
rs692180 2096 dbSNP
rs1326450820 2099 dbSNP
rs141802218 2100 dbSNP
rs776939484 2108 dbSNP
rs1405030436 2117 dbSNP
rs544700252 2118 dbSNP
rs1322168391 2123 dbSNP
rs1382125946 2129 dbSNP
rs183542930 2134 dbSNP
rs886052963 2135 dbSNP
rs1160490040 2140 dbSNP
rs940464622 2142 dbSNP
rs1411514221 2164 dbSNP
rs770763503 2165 dbSNP
rs1177170715 2169 dbSNP
rs1481473479 2174 dbSNP
rs1379258393 2175 dbSNP
rs1196722551 2179 dbSNP
rs1450799956 2181 dbSNP
rs146025743 2185 dbSNP
rs928285806 2190 dbSNP
rs563896823 2195 dbSNP
rs1346542166 2196 dbSNP
rs935157651 2200 dbSNP
rs937035940 2203 dbSNP
rs1233222037 2209 dbSNP
rs1327374603 2216 dbSNP
rs1322893137 2240 dbSNP
rs1433369239 2244 dbSNP
rs1388124044 2248 dbSNP
rs1040223332 2249 dbSNP
rs901686213 2260 dbSNP
rs1400223646 2267 dbSNP
rs1055963498 2270 dbSNP
rs893429320 2274 dbSNP
rs1170733039 2279 dbSNP
rs1012119560 2288 dbSNP
rs996015116 2290 dbSNP
rs1028924207 2299 dbSNP
rs1447454982 2300 dbSNP
rs1323769389 2307 dbSNP
rs1041895620 2311 dbSNP
rs372226654 2312 dbSNP
rs1438104005 2315 dbSNP
rs552942446 2317 dbSNP
rs1008328655 2322 dbSNP
rs1200381636 2330 dbSNP
rs1340606254 2345 dbSNP
rs376601294 2349 dbSNP
rs1300476620 2368 dbSNP
rs1226600107 2371 dbSNP
rs1364976356 2377 dbSNP
rs1315971767 2395 dbSNP
rs1332725487 2413 dbSNP
rs1357502658 2415 dbSNP
rs115371692 2419 dbSNP
rs964033857 2420 dbSNP
rs374104069 2426 dbSNP
rs996891591 2432 dbSNP
rs1425979015 2433 dbSNP
rs1371034188 2448 dbSNP
rs1170443817 2459 dbSNP
rs1028877205 2470 dbSNP
rs143133684 2475 dbSNP
rs546598294 2476 dbSNP
rs972896862 2486 dbSNP
rs1410326965 2487 dbSNP
rs1235397937 2493 dbSNP
rs1186164595 2494 dbSNP
rs886052964 2502 dbSNP
rs907720455 2503 dbSNP
rs1203699934 2505 dbSNP
rs962210236 2509 dbSNP
rs886052965 2520 dbSNP
rs1341883609 2528 dbSNP
rs981201241 2530 dbSNP
rs562655160 2532 dbSNP
rs76156285 2533 dbSNP
rs1377171802 2545 dbSNP
rs1283839865 2547 dbSNP
rs960874118 2553 dbSNP
rs937004875 2554 dbSNP
rs1407981466 2557 dbSNP
rs1369712460 2558 dbSNP
rs1055390815 2576 dbSNP
rs1165134647 2588 dbSNP
rs763118529 2590 dbSNP
rs991454430 2603 dbSNP
rs916861299 2609 dbSNP
rs186556135 2612 dbSNP
rs1042253729 2613 dbSNP
rs1458201459 2614 dbSNP
rs1180646899 2615 dbSNP
rs903331076 2624 dbSNP
rs774929925 2627 dbSNP
rs1270257153 2654 dbSNP
rs1224171949 2655 dbSNP
rs923689711 2661 dbSNP
rs905712898 2665 dbSNP
rs113390675 2674 dbSNP
rs1286602833 2674 dbSNP
rs796305511 2674 dbSNP
rs886052966 2674 dbSNP
rs1409290422 2682 dbSNP
rs1349744572 2684 dbSNP
rs944239549 2688 dbSNP
rs1041149966 2702 dbSNP
rs899923476 2712 dbSNP
rs1322461047 2718 dbSNP
rs1180968059 2722 dbSNP
rs146698137 2724 dbSNP
rs1413724452 2729 dbSNP
rs1156251450 2730 dbSNP
rs1027001036 2731 dbSNP
rs1426435995 2734 dbSNP
rs1163571839 2739 dbSNP
rs1416731942 2740 dbSNP
rs1459485305 2741 dbSNP
rs931835159 2744 dbSNP
rs1209590812 2747 dbSNP
rs1172277234 2750 dbSNP
rs1400376050 2751 dbSNP
rs1050754287 2754 dbSNP
rs1324417166 2755 dbSNP
rs1392530066 2757 dbSNP
rs1220934980 2759 dbSNP
rs1365223169 2766 dbSNP
rs1273961871 2776 dbSNP
rs191738448 2778 dbSNP
rs755732323 2787 dbSNP
rs1318161691 2797 dbSNP
rs539257353 2800 dbSNP
rs886052967 2801 dbSNP
rs1178851856 2805 dbSNP
rs897163785 2819 dbSNP
rs1285081037 2830 dbSNP
rs1425086478 2839 dbSNP
rs139115520 2848 dbSNP
rs762083428 2853 dbSNP
rs1208402227 2876 dbSNP
rs1483612867 2879 dbSNP
rs1257905930 2903 dbSNP
rs1231667002 2907 dbSNP
rs961895861 2908 dbSNP
rs566449657 2916 dbSNP
rs1367141677 2920 dbSNP
rs533168611 2933 dbSNP
rs1318674810 2937 dbSNP
rs1035362444 2938 dbSNP
rs1433977891 2942 dbSNP
rs1195257556 2951 dbSNP
rs149904153 2958 dbSNP
rs968368712 2962 dbSNP
rs1359042001 2969 dbSNP
rs1169827322 2970 dbSNP
rs145828729 2976 dbSNP
rs753514553 2977 dbSNP
rs886052968 2982 dbSNP
rs935010477 2992 dbSNP
rs975781951 3006 dbSNP
rs1256525534 3010 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions TZM-bl
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM1462574. RNA binding protein: AGO2. Condition:TZM-bl ami BaL ...

- Whisnant AW; Bogerd HP; Flores O; Ho P; et al., 2013, mBio.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' ccugagaugucuGUGUGGa 5'
                      |||||| 
Target 5' -----------uCACACCa 3'
 		1 - 8
Article - Whisnant AW; Bogerd HP; Flores O; Ho P; et al.
- mBio, 2013
UNLABELLED: The question of how HIV-1 interfaces with cellular microRNA (miRNA) biogenesis and effector mechanisms has been highly controversial. Here, we first used deep sequencing of small RNAs present in two different infected cell lines (TZM-bl and C8166) and two types of primary human cells (CD4(+) peripheral blood mononuclear cells [PBMCs] and macrophages) to unequivocally demonstrate that HIV-1 does not encode any viral miRNAs. Perhaps surprisingly, we also observed that infection of T cells by HIV-1 has only a modest effect on the expression of cellular miRNAs at early times after infection. Comprehensive analysis of miRNA binding to the HIV-1 genome using the photoactivatable ribonucleoside-induced cross-linking and immunoprecipitation (PAR-CLIP) technique revealed several binding sites for cellular miRNAs, a subset of which were shown to be capable of mediating miRNA-mediated repression of gene expression. However, the main finding from this analysis is that HIV-1 transcripts are largely refractory to miRNA binding, most probably due to extensive viral RNA secondary structure. Together, these data demonstrate that HIV-1 neither encodes viral miRNAs nor strongly influences cellular miRNA expression, at least early after infection, and imply that HIV-1 transcripts have evolved to avoid inhibition by preexisting cellular miRNAs by adopting extensive RNA secondary structures that occlude most potential miRNA binding sites. IMPORTANCE: MicroRNAs (miRNAs) are a ubiquitous class of small regulatory RNAs that serve as posttranscriptional regulators of gene expression. Previous work has suggested that HIV-1 might subvert the function of the cellular miRNA machinery by expressing viral miRNAs or by dramatically altering the level of cellular miRNA expression. Using very sensitive approaches, we now demonstrate that neither of these ideas is in fact correct. Moreover, HIV-1 transcripts appear to largely avoid regulation by cellular miRNAs by adopting an extensive RNA secondary structure that occludes the ability of cellular miRNAs to interact with viral mRNAs. Together, these data suggest that HIV-1, rather than seeking to control miRNA function in infected cells, has instead evolved a mechanism to become largely invisible to cellular miRNA effector mechanisms.
LinkOut: [PMID: 23592263]
CLIP-seq Support 1 for dataset GSM1462574
Method / RBP PAR-CLIP / AGO2
Cell line / Condition TZM-bl / TZM-bl ami BaL
Location of target site ENST00000253801.2 | 3UTR | UCACACCAUUGCACUCCAACCUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23592263 / GSE59944
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
Click to see details
Click to see details
121 hsa-miR-3650 Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT075340 SF3B3 splicing factor 3b subunit 3 2 2
MIRT302326 ACP1 acid phosphatase 1, soluble 2 2
MIRT395212 PRKCB protein kinase C beta 2 2
MIRT404446 PLEKHA1 pleckstrin homology domain containing A1 2 2
MIRT449647 CASS4 Cas scaffolding protein family member 4 2 2
MIRT451262 NDUFA11 NADH:ubiquinone oxidoreductase subunit A11 2 2
MIRT452113 IFITM1 interferon induced transmembrane protein 1 2 2
MIRT452723 AGAP9 ArfGAP with GTPase domain, ankyrin repeat and PH domain 9 2 4
MIRT452982 CABP4 calcium binding protein 4 2 2
MIRT453966 ATP13A4 ATPase 13A4 2 6
MIRT454112 MRPL52 mitochondrial ribosomal protein L52 2 2
MIRT454343 CDKL1 cyclin dependent kinase like 1 2 2
MIRT454405 AKAP5 A-kinase anchoring protein 5 2 2
MIRT456224 LIX1L limb and CNS expressed 1 like 2 4
MIRT456232 LHPP phospholysine phosphohistidine inorganic pyrophosphate phosphatase 2 6
MIRT458505 GSG2 histone H3 associated protein kinase 2 6
MIRT461653 G6PC glucose-6-phosphatase catalytic subunit 2 2
MIRT461933 TNFSF14 TNF superfamily member 14 2 2
MIRT462734 EFNB1 ephrin B1 2 2
MIRT463817 XKR4 XK related 4 2 2
MIRT463833 WSB1 WD repeat and SOCS box containing 1 2 2
MIRT464928 TXLNA taxilin alpha 2 2
MIRT465874 TMEM43 transmembrane protein 43 2 4
MIRT467753 SLC35F1 solute carrier family 35 member F1 2 4
MIRT468688 SEC22C SEC22 homolog C, vesicle trafficking protein 2 4
MIRT469453 REL REL proto-oncogene, NF-kB subunit 2 6
MIRT471931 NRAS NRAS proto-oncogene, GTPase 2 2
MIRT474715 KIF13A kinesin family member 13A 2 6
MIRT475396 ICMT isoprenylcysteine carboxyl methyltransferase 2 2
MIRT475681 HHIPL1 HHIP like 1 2 2
MIRT477016 FAM217B family with sequence similarity 217 member B 2 2
MIRT477073 FAM208A family with sequence similarity 208 member A 2 4
MIRT478172 DENND5B DENN domain containing 5B 2 2
MIRT478995 COLGALT1 collagen beta(1-O)galactosyltransferase 1 2 2
MIRT479700 CCNT1 cyclin T1 2 2
MIRT482784 STIM1 stromal interaction molecule 1 2 2
MIRT488682 RAD23B RAD23 homolog B, nucleotide excision repair protein 2 2
MIRT493179 MKNK2 MAP kinase interacting serine/threonine kinase 2 2 2
MIRT494243 CHAC1 ChaC glutathione specific gamma-glutamylcyclotransferase 1 2 2
MIRT508775 GSG1 germ cell associated 1 2 2
MIRT509555 ACTG1 actin gamma 1 2 4
MIRT510305 PDRG1 p53 and DNA damage regulated 1 2 2
MIRT510976 PFN2 profilin 2 2 6
MIRT517860 NCAPD2 non-SMC condensin I complex subunit D2 2 4
MIRT519451 CSTF1 cleavage stimulation factor subunit 1 2 2
MIRT521340 RPP14 ribonuclease P/MRP subunit p14 2 2
MIRT522478 MIPOL1 mirror-image polydactyly 1 2 4
MIRT522584 MAPK1IP1L mitogen-activated protein kinase 1 interacting protein 1 like 2 2
MIRT525629 NUP93 nucleoporin 93 2 4
MIRT529240 PORCN porcupine O-acyltransferase 2 2
MIRT529788 AP4S1 adaptor related protein complex 4 sigma 1 subunit 2 2
MIRT530567 ABHD15 abhydrolase domain containing 15 2 2
MIRT535784 MTRNR2L11 MT-RNR2-like 11 2 6
MIRT536819 HMGA1 high mobility group AT-hook 1 2 2
MIRT541615 C11orf31 selenoprotein H 2 2
MIRT546188 TPD52 tumor protein D52 2 4
MIRT546201 TOR1AIP2 torsin 1A interacting protein 2 2 2
MIRT547466 MBNL3 muscleblind like splicing regulator 3 2 8
MIRT550570 SLC2A5 solute carrier family 2 member 5 2 2
MIRT550778 DBT dihydrolipoamide branched chain transacylase E2 2 4
MIRT550987 RBM38 RNA binding motif protein 38 2 2
MIRT554735 RHOC ras homolog family member C 2 2
MIRT555390 PPM1L protein phosphatase, Mg2+/Mn2+ dependent 1L 2 2
MIRT556871 IVNS1ABP influenza virus NS1A binding protein 2 2
MIRT557530 GPBP1L1 GC-rich promoter binding protein 1 like 1 2 2
MIRT564850 ZBED3 zinc finger BED-type containing 3 2 2
MIRT569426 DCAF8 DDB1 and CUL4 associated factor 8 2 2
MIRT569479 CTSE cathepsin E 2 2
MIRT569653 SLC23A1 solute carrier family 23 member 1 2 2
MIRT570089 KANSL1L KAT8 regulatory NSL complex subunit 1 like 2 4
MIRT574074 RNF152 ring finger protein 152 2 2
MIRT575199 Entpd4 ectonucleoside triphosphate diphosphohydrolase 4 2 2
MIRT606929 CDK15 cyclin dependent kinase 15 2 2
MIRT606959 BDH1 3-hydroxybutyrate dehydrogenase 1 2 6
MIRT606968 FAM117B family with sequence similarity 117 member B 2 2
MIRT606975 ONECUT3 one cut homeobox 3 2 2
MIRT607002 KCNQ5 potassium voltage-gated channel subfamily Q member 5 2 2
MIRT607129 MARCH4 membrane associated ring-CH-type finger 4 2 2
MIRT607185 SPRY4 sprouty RTK signaling antagonist 4 2 4
MIRT607547 GLI2 GLI family zinc finger 2 2 2
MIRT607617 TMEM130 transmembrane protein 130 2 4
MIRT607638 FAM69C family with sequence similarity 69 member C 2 2
MIRT607690 MAPK10 mitogen-activated protein kinase 10 2 2
MIRT607810 SPATA6 spermatogenesis associated 6 2 2
MIRT607945 SSX2 SSX family member 2 2 4
MIRT608018 CARNS1 carnosine synthase 1 2 2
MIRT608066 SSX2B SSX family member 2B 2 4
MIRT608833 PTCHD1 patched domain containing 1 2 4
MIRT608857 TCTE1 t-complex-associated-testis-expressed 1 2 2
MIRT608863 BCAS1 breast carcinoma amplified sequence 1 2 2
MIRT608871 NR2E1 nuclear receptor subfamily 2 group E member 1 2 2
MIRT608949 CYP7B1 cytochrome P450 family 7 subfamily B member 1 2 2
MIRT608994 PYGO1 pygopus family PHD finger 1 2 2
MIRT609060 LPP LIM domain containing preferred translocation partner in lipoma 2 2
MIRT609066 IGLON5 IgLON family member 5 2 4
MIRT610789 KLK2 kallikrein related peptidase 2 2 2
MIRT620567 WBSCR27 methyltransferase like 27 2 4
MIRT624028 EN2 engrailed homeobox 2 2 2
MIRT626738 TXNL4B thioredoxin like 4B 2 2
MIRT627162 ZNF48 zinc finger protein 48 2 2
MIRT627198 ZDHHC20 zinc finger DHHC-type containing 20 2 2
MIRT631188 TSPAN14 tetraspanin 14 2 2
MIRT631967 YIPF5 Yip1 domain family member 5 2 2
MIRT632888 GINM1 glycoprotein integral membrane 1 2 2
MIRT636752 SLC16A5 solute carrier family 16 member 5 2 2
MIRT637769 PDLIM3 PDZ and LIM domain 3 2 2
MIRT640735 FAM83C family with sequence similarity 83 member C 2 2
MIRT645611 TSPAN6 tetraspanin 6 2 2
MIRT653679 SLC25A36 solute carrier family 25 member 36 2 2
MIRT654119 RPS6KA5 ribosomal protein S6 kinase A5 2 2
MIRT655110 PHLDA3 pleckstrin homology like domain family A member 3 2 2
MIRT662230 PGBD4 piggyBac transposable element derived 4 2 2
MIRT662332 MYLK3 myosin light chain kinase 3 2 2
MIRT662730 LRRC3C leucine rich repeat containing 3C 2 2
MIRT668622 EEA1 early endosome antigen 1 2 2
MIRT687702 KRR1 KRR1, small subunit processome component homolog 2 2
MIRT691171 APOL6 apolipoprotein L6 2 2
MIRT701450 NFIC nuclear factor I C 2 2
MIRT705501 ASH1L ASH1 like histone lysine methyltransferase 2 2
MIRT706893 ST3GAL1 ST3 beta-galactoside alpha-2,3-sialyltransferase 1 2 2
MIRT707402 KCNK12 potassium two pore domain channel subfamily K member 12 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-3650 Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-3650 Paclitaxel/Docetaxel/Vinorelbine/Doxorubicin/Etoposide resistant cell line (Bads-200)

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