miRTarBase - #MIRT462899


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pre-miRNA Information
pre-miRNA hsa-mir-4776-1   
Genomic Coordinates chr2: 212926257 - 212926336
Description Homo sapiens miR-4776-1 stem-loop
Comment None
RNA Secondary Structure
pre-miRNA hsa-mir-4776-2   
Genomic Coordinates chr2: 212926257 - 212926336
Description Homo sapiens miR-4776-2 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-4776-5p
Sequence 10| GUGGACCAGGAUGGCAAGGGCU |31
Evidence Experimental
Experiments Illumina
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs982906747 5 dbSNP
rs953060487 6 dbSNP
rs965980067 8 dbSNP
rs547466728 9 dbSNP
rs1269946481 12 dbSNP
rs1220781023 14 dbSNP
rs1350638372 18 dbSNP
rs1356074101 19 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol ZNRF3   
Synonyms BK747E2.3, RNF203
Description zinc and ring finger 3
Transcript NM_032173   
Expression
Putative miRNA Targets on ZNRF3
3'UTR of ZNRF3
(miRNA target sites are highlighted)		 
>ZNRF3|NM_032173|3'UTR
   1 GCTCAGGAGGAACTCTTACCTGGAAATTGGGAACTGTATGGAGACTCCAAACTGACTTCTTTCAAAAAACAAAAACAAAA
  81 AATTTTTTTAGCTTTGACAAACACACAAAAGTGGTAATAAAGAGAGCCCTCCTTGTCAACCCAAAATGTGAGCCCCCTGT
 161 GGCAAAACCACCCCCTACCCCATTAACAAATCAACAGACAAAATTCTCCGAGTCCTTTGCCTCTTTTGATAACATGTTGT
 241 TCTGTTTTGTAAAGTGTGTGTGCTTGGGGTTCCGAGGTGTGGGATTGAGTTCTCTGCTTTGTTTTTTTTTAAGATATTGT
 321 ATGTAAATGTAAAAAGTTATTTAAATATATATTTTAAAGAACCCTAACTGCCAACTTTTGCTGAAAAAGAAAAAAAAATC
 401 ACTGCTGCATTAAATGAACCACATCATGTGTAGATACTGTTGTCTCCCTGAAGGGAGCTCAGGCCTTTGAAAAGCTCAGG
 481 GCTTCACCTGCCTTAGAAAATGAACCAGAAACTTGAAGTAAAGCTAGTTGATAGGGGTACAGGCTCTGAGGAGCAGTGCA
 561 AAACTGCCTCTTTCTTTCTCGTGGCAAATCCCAATGTACACGATTTCAGGTCTCAGACGCCATGCCTCTCCAGCCCACGC
 641 CTTTAGGCAGGTGATGGCAGCAGCTAGGAATAGGGTGTACATGATCCACAGCCCTGCGGAGCCAGGTCAAGCCGCTGCTA
 721 TGAAAGCTCCAGGGTGATGGGGACGATTCTGCCCAGTGTCCTCAGTCTGTCCCCTCAGGTCATGGTCCCAAGTGAAATGA
 801 CAGAGTTCACAGCCCTGGTCTTGGCTGAGGTCCAGGTCATAGTAAGGGCATGTTCTTGGGGCCCTCGACCTGAACTCTGA
 881 CCCTCCGGGCAGGGAAGAGGAGGTTGTCCCCTTTGGTTGTCCTGGCTTTGGAGTCCTTTGCAAAAATATTTTGGGCCCCC
 961 TGCCACTGGCTGCAGAAATGGCTCGACGGGGTGTGTGGGGACAGACACCCAGAAGGAATGTACTTTTGTGGCCTTGGTGT
1041 CCGATGGGGCTGGGGGAGAGTGCTCTCCACTGACCCAGCAGCACACCCATGTGCAGTGCGCCTGCATCTGTGTGGGGGCA
1121 GCCACACCCCTTGGCTGCTGCTTCCTTGGGCTGCCTTTCTGGGGGCATGTGACTGGACCTACGAGGTCTGCACTGAGCTC
1201 CATTTGAATGATACCTTTCCTATCCCATTTCCCCCACGGAAGCACCGCTTCAGGGTTATTCAGTCCTCTGCCTCATGGCT
1281 GAAATTGCTCATCTCGTCTGCAGATGTCTACTATCCTGTCTACCTAATGCACTATTATGTATTGATTCTCCATGAGACAG
1361 AGAGAGAGAGAGACTATCAGATAGTTTACACCCAAAGGGTAGGTTTTTGTATATTTTTCCAGCCTTTTTTATTAAGGGGA
1441 AGGGGAGAGTTTAAAAACCCAAACCGTTGTGGTTTTAAGGTGTTTCATTTTTAAAAGGGAGAGAGAATCTATTTAAAGCT
1521 ATTTCAGATCAGGGATTGTCATCCTTTTTTGTCCAATGTATTCCTTGTTCTTTAAAAAAATTTTTTTTAGAGGAAACTAA
1601 TATTAGTCTTTGTGTTCACTAACTCTTCTGGTCACTTGTATTTATTTATTCATTCATTCATCAGATATTTGTTGCCATCT
1681 GAAAGAACTGGCCCAGTGGGTCTGAAAGCTCGCTTGAGAATAGGAAACTTGAGACCTGGCCCCCTGTGGGTAGGAGAACA
1761 AGGACCACCTGGGTTCTCCAGTCTTGAACGAGAATCTCACTCTTATCAGAATGTTTTTCTTAACCTCAGCGTATGATGAG
1841 GAAATTTACTTATCTCTAGCTAGGATTTGACAAATTCCAACATCAAATGATCAAAACATTTGCCACTGAGGCTTCACTGG
1921 TGAGATCCGTTCTCCGTCCTCGGGTGCAGTCCCTTGGGGGCTGCTCCTCGGACTGCGCCCCGCACACCTGTTATCGAGGG
2001 TGTGAGAAGCGCCTAAGCTGGTGACATGTGATCTGGGACGCCTTCATTTCTCGGGCCAGGAGTAGCAGCTGCTAAGGACA
2081 GCAGCTTGCATTGCGTGGTTTTAGGGAAGCAGGGTCTGGCTTTTAATATGAACTGCAAAAAGCAGCTTCTCACTGATATT
2161 TTTTTGTTGTTGTTTCTGGGGGGTTTTTTTGTTTTGTTTTTAATGCCTTTGAGTGCATATTTTCTTCCTCGTCTGAAACC
2241 GAACTCCCAAAGTGGCTTTCTTTAGCCCTGGCTGGAAAACCACCTCTCAATAGCCTTAAGCAATAAATAGATGAGTAGAG
2321 AATGTGGCTTCAACTGGGCTTATTAAAGTAAGTGTGTCTAGTTTTCACTTGAACAAGTGATAGCTGCAGATGGCGAAAGA
2401 AACCCATTTAATTTTTGTAGCTTACAGGTGGTAGAAACAAAAATGCAATTTTAAAACCTTAAATACCAAATACCAACCAT
2481 TGCCTTTTTTTTTTTTGAGATGGAATTTTGCTCTTGTCACCCAGGCTGGAGTGCAATGGCGCGATCTCACCTCACTGCAA
2561 CCTCTGCCTCCCGGGTCCAAGTGATTCTCCTGCCTCAGCCTCCCAAGTAGCTGGGATTACAGGCATGCGCCACCACACCC
2641 AGCTAATTTTGTATTTTTGGTAGAGACAGGGTATCTCCATGTTGGTCAGGCTGGTCTTGGATTCCCGACCTCAGGTGATC
2721 CGCCCACCTCGGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACCATGCCTGCCCAGCAATACCAACCATTGTCTTT
2801 TAAATTCGTGTTGGCTTCTCAGACAGGGAGATCACTGGAATAAAATAACCGATGGTCTTATTTTGTCACACGTAAATCAA
2881 AAGAAATGTCCTCTTTGAAGTTGTAAGACTCCACCAATGACAGACACCCTTTTCGGTGGACTCTGAGTGGTGTGTAGTGG
2961 TTTTATAGCCATGGAAACTAGGAGTATCTCACTTTCCACTGAGAACCCCTGCCCCCAATCCCTCTAAGTTGGGGTGTGGC
3041 AGTTGGGCAGGGTCAAGTGACCCAGCCCTGGCTGTAGGACAGCCATATACAGTGAAGAGTTCTAGAACCAGCTAAAAATG
3121 GAAGTTTGGGTGTTTACCAACAAGGTACCTCTTTATGGATGCAGCCCCAGTAAGCTGGCTTTAACTCTCAGCTCCTTCCC
3201 TGTCTCCTCCTAATCCAAGCCCTTTTATAAAATAAAGCCCCTTCTGTCCCACTGCTCACATACTTATGTGCTGCTAGTCT
3281 CTACTCGAAGTTCGTGCAGGACTAATGCTTTTAAAATGAGGTCTAAAAAATAATTACTAGTCGAGACTATTATTCTTTAA
3361 ACAGAACTGCCTTTTTCTACTCTTTATGTAAACTCTTTCTATTGTGTTGGTCTAACAAGGCACTATTTTAAAATTTTTTA
3441 ATTTTTCCCATAGCACTTAAAAGAGATTTTGTAAAGACCTTGCTGTAAAGATTTTGTAATAAAATGGTCTAAGGGCTCTT
3521 TTTCCAACATTACCATTTTTAAAAAATGTTTTAAAAGCTAGAAGACAACTTATGTATATTCTGTATATGTATAGCAGCAC
3601 ATTTCATTTATGGAAATATGTTCTCAGAATATTTATTTACTAATATATTTATCTTAAGCCATGTCTTATGTTGAGAGTGT
3681 GACATTGTTGGAATAATCATTGAAAATGACTAACACAAGACCCTGTAAATACATGATAATTGCACACAGATTTTACATAT
3761 TTGCAGACCAAAAATGATTTAAAACAAGTTGTAGTCTTCTATGGTTTTGTAACAAATTGTACACATGACTGTAAAAAAAA
3841 AATACAATTTTATCAAGTATGTGTTAAAAAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' ucGGGAACGGUAG---GACCAGGUg 5'
            |:||| |:||:   :|||||:| 
Target 5' aaCTCTTTCTATTGTGTTGGTCTAa 3'
 3391 - 3415 148.00 -17.30
2 
miRNA  3' ucGGGAACGGUAGGACCAGGUg 5'
            ||: ||||  || |||||| 
Target 5' aaCCTCTGCCTCCCGGGTCCAa 3'
 2559 - 2580 140.00 -25.70
3 
miRNA  3' ucGGGAACGGUAGGACCAGGug 5'
            ||| |   :|| ||||||  
Target 5' gtCCCCTCAGGTCATGGTCCca 3'
 769 - 790 136.00 -18.60
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30521692 11 COSMIC
COSN31569109 35 COSMIC
COSN30506248 83 COSMIC
COSN13908486 84 COSMIC
COSN30135514 87 COSMIC
COSN20066044 90 COSMIC
COSN31526019 104 COSMIC
COSN31596525 117 COSMIC
COSN31957358 153 COSMIC
COSN28850959 311 COSMIC
COSN9163752 618 COSMIC
COSN16455271 676 COSMIC
COSN10029285 682 COSMIC
COSN5454997 868 COSMIC
COSN5269037 993 COSMIC
COSN31544287 1009 COSMIC
COSN28197971 1016 COSMIC
COSN31556077 1040 COSMIC
COSN30174222 1068 COSMIC
COSN31514373 1100 COSMIC
COSN28198300 1154 COSMIC
COSN24307404 1168 COSMIC
COSN20117330 1236 COSMIC
COSN9163753 1295 COSMIC
COSN8869029 1314 COSMIC
COSN28447505 1373 COSMIC
COSN31603294 1452 COSMIC
COSN13908503 1582 COSMIC
COSN9163754 1822 COSMIC
COSN20721282 1970 COSMIC
COSN8016140 1978 COSMIC
COSN32170775 2131 COSMIC
COSN20117338 2201 COSMIC
COSN24723684 2498 COSMIC
COSN8016141 2823 COSMIC
COSN4784982 3426 COSMIC
COSN28250350 3717 COSMIC
COSN31961961 3813 COSMIC
COSN20117341 3843 COSMIC
rs62236881 584 GWAS
rs2179129 1314 GWAS
rs4823006 2062 GWAS
rs12321 3584 GWAS
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs754079534 2 dbSNP
rs755150120 5 dbSNP
rs779054124 6 dbSNP
rs1184682208 7 dbSNP
rs1242991553 8 dbSNP
rs1443150334 11 dbSNP
rs748117655 14 dbSNP
rs1217015538 17 dbSNP
rs763069029 18 dbSNP
rs1159293094 19 dbSNP
rs1453272955 20 dbSNP
rs772178000 22 dbSNP
rs778209636 25 dbSNP
rs747497017 28 dbSNP
rs1021105248 30 dbSNP
rs1380377094 34 dbSNP
rs1448686592 36 dbSNP
rs771444558 37 dbSNP
rs777097749 39 dbSNP
rs1236365046 44 dbSNP
rs1182385859 62 dbSNP
rs1485705868 63 dbSNP
rs1411057128 64 dbSNP
rs1241693795 65 dbSNP
rs1321644222 71 dbSNP
rs1429893858 75 dbSNP
rs1282926033 78 dbSNP
rs886897688 83 dbSNP
rs1000583210 84 dbSNP
rs1325381365 85 dbSNP
rs187445134 89 dbSNP
rs953715090 90 dbSNP
rs1289218553 101 dbSNP
rs35434079 101 dbSNP
rs552471945 101 dbSNP
rs949239939 103 dbSNP
rs1407419703 131 dbSNP
rs1452614758 133 dbSNP
rs1480452273 148 dbSNP
rs1430788378 153 dbSNP
rs987454605 154 dbSNP
rs1263101234 168 dbSNP
rs1207228871 169 dbSNP
rs1055824350 170 dbSNP
rs1262692947 171 dbSNP
rs1046231585 172 dbSNP
rs1364258021 175 dbSNP
rs961828585 176 dbSNP
rs1382981972 178 dbSNP
rs905077605 179 dbSNP
rs920107192 180 dbSNP
rs1325765023 192 dbSNP
rs747153917 195 dbSNP
rs1436960470 196 dbSNP
rs1055699550 210 dbSNP
rs893118766 211 dbSNP
rs570686631 213 dbSNP
rs868165815 220 dbSNP
rs1165626653 224 dbSNP
rs1264791178 234 dbSNP
rs1461079687 234 dbSNP
rs200809710 235 dbSNP
rs552739514 239 dbSNP
rs534305712 241 dbSNP
rs945304944 254 dbSNP
rs73882449 256 dbSNP
rs903704189 258 dbSNP
rs1462816941 262 dbSNP
rs574116785 270 dbSNP
rs1186597646 274 dbSNP
rs1008772784 275 dbSNP
rs1340191645 280 dbSNP
rs1019787283 286 dbSNP
rs964259408 290 dbSNP
rs1230543315 300 dbSNP
rs1314088208 302 dbSNP
rs201334273 302 dbSNP
rs1453163024 322 dbSNP
rs975679676 323 dbSNP
rs1341858343 324 dbSNP
rs920205378 330 dbSNP
rs1049505120 361 dbSNP
rs1260559045 362 dbSNP
rs889439404 365 dbSNP
rs1423287301 366 dbSNP
rs1385221976 371 dbSNP
rs1164584937 376 dbSNP
rs1446865723 380 dbSNP
rs1179006466 389 dbSNP
rs1220424217 390 dbSNP
rs1237831948 390 dbSNP
rs1252766543 390 dbSNP
rs199953416 390 dbSNP
rs952350786 390 dbSNP
rs1019719468 398 dbSNP
rs982508536 405 dbSNP
rs1174650478 408 dbSNP
rs1246383803 422 dbSNP
rs908249604 423 dbSNP
rs1277349305 426 dbSNP
rs1347480552 429 dbSNP
rs771015860 431 dbSNP
rs1309301489 438 dbSNP
rs777057987 442 dbSNP
rs1431482864 447 dbSNP
rs1365474527 448 dbSNP
rs760069353 451 dbSNP
rs1407387162 452 dbSNP
rs952897590 456 dbSNP
rs763547028 465 dbSNP
rs937871738 471 dbSNP
rs541479859 480 dbSNP
rs1158148340 483 dbSNP
rs1407044754 487 dbSNP
rs1053616056 488 dbSNP
rs1197320572 494 dbSNP
rs16987090 498 dbSNP
rs1268030654 510 dbSNP
rs775974762 525 dbSNP
rs1218561790 531 dbSNP
rs1276347317 533 dbSNP
rs1223061110 543 dbSNP
rs76158396 559 dbSNP
rs762482079 562 dbSNP
rs1215822119 564 dbSNP
rs1217287166 568 dbSNP
rs913236271 568 dbSNP
rs1289878479 577 dbSNP
rs763875339 578 dbSNP
rs1221113635 582 dbSNP
rs62236881 584 dbSNP
rs34966056 590 dbSNP
rs1284426559 593 dbSNP
rs1439230602 596 dbSNP
rs543683786 597 dbSNP
rs903232991 600 dbSNP
rs1318042980 602 dbSNP
rs1487086958 603 dbSNP
rs1391051827 610 dbSNP
rs1174573041 615 dbSNP
rs1008325166 616 dbSNP
rs1480116911 617 dbSNP
rs1020177204 619 dbSNP
rs1478961017 620 dbSNP
rs1240336355 622 dbSNP
rs1214772247 623 dbSNP
rs565557172 624 dbSNP
rs1270036494 625 dbSNP
rs1480283620 626 dbSNP
rs964188134 627 dbSNP
rs1263217671 628 dbSNP
rs936541990 631 dbSNP
rs1360451173 639 dbSNP
rs1410744904 640 dbSNP
rs80311519 642 dbSNP
rs1201388671 644 dbSNP
rs1367809508 669 dbSNP
rs1334882309 672 dbSNP
rs1027238682 673 dbSNP
rs183941891 674 dbSNP
rs1407187461 681 dbSNP
rs767165756 683 dbSNP
rs1008408987 696 dbSNP
rs750336103 698 dbSNP
rs1040681760 699 dbSNP
rs1449788260 701 dbSNP
rs908217695 704 dbSNP
rs970861822 711 dbSNP
rs1181601519 712 dbSNP
rs1358743046 714 dbSNP
rs559736386 715 dbSNP
rs189456673 718 dbSNP
rs766055297 721 dbSNP
rs1053585522 730 dbSNP
rs1215669483 739 dbSNP
rs561055602 742 dbSNP
rs1034535494 745 dbSNP
rs945320929 748 dbSNP
rs1440053774 756 dbSNP
rs548655590 757 dbSNP
rs913192266 761 dbSNP
rs570098765 778 dbSNP
rs977969046 789 dbSNP
rs944059620 793 dbSNP
rs1256359479 797 dbSNP
rs1183250195 801 dbSNP
rs1350948129 802 dbSNP
rs1231809434 810 dbSNP
rs1205323688 819 dbSNP
rs1484310035 824 dbSNP
rs1041128681 825 dbSNP
rs1290269089 830 dbSNP
rs925228900 847 dbSNP
rs1224094223 857 dbSNP
rs1315040421 859 dbSNP
rs1222289804 867 dbSNP
rs1291972177 867 dbSNP
rs1490092328 868 dbSNP
rs899958087 871 dbSNP
rs145999339 876 dbSNP
rs1235008016 877 dbSNP
rs911056280 881 dbSNP
rs1368833023 883 dbSNP
rs1166737156 884 dbSNP
rs1027164906 887 dbSNP
rs1406855896 888 dbSNP
rs888674481 890 dbSNP
rs777918256 891 dbSNP
rs1004489998 900 dbSNP
rs1267325027 902 dbSNP
rs192612914 903 dbSNP
rs1488974392 905 dbSNP
rs752314755 912 dbSNP
rs929657817 923 dbSNP
rs138609511 936 dbSNP
rs1289248445 941 dbSNP
rs1378535277 952 dbSNP
rs534577347 965 dbSNP
rs970408535 967 dbSNP
rs982216948 973 dbSNP
rs1343731465 983 dbSNP
rs1033385257 985 dbSNP
rs1048659381 986 dbSNP
rs1391446540 988 dbSNP
rs1295040536 989 dbSNP
rs755671010 992 dbSNP
rs936225028 993 dbSNP
rs747241765 999 dbSNP
rs1344188455 1001 dbSNP
rs552852924 1011 dbSNP
rs1473247971 1013 dbSNP
rs915089524 1014 dbSNP
rs1198134178 1027 dbSNP
rs1434249678 1033 dbSNP
rs567678612 1043 dbSNP
rs757207274 1044 dbSNP
rs1321304367 1046 dbSNP
rs911826302 1053 dbSNP
rs535124716 1057 dbSNP
rs1356132455 1059 dbSNP
rs1020820636 1060 dbSNP
rs1442823258 1061 dbSNP
rs1330527336 1064 dbSNP
rs944050711 1069 dbSNP
rs556995970 1076 dbSNP
rs1303348120 1081 dbSNP
rs1380272441 1083 dbSNP
rs35262642 1086 dbSNP
rs899884336 1090 dbSNP
rs1247488089 1091 dbSNP
rs932736740 1094 dbSNP
rs1048572238 1099 dbSNP
rs542773854 1100 dbSNP
rs575278105 1101 dbSNP
rs545898354 1107 dbSNP
rs201356225 1109 dbSNP
rs1004819009 1113 dbSNP
rs1015837405 1115 dbSNP
rs1226293824 1116 dbSNP
rs558853189 1119 dbSNP
rs1428233514 1124 dbSNP
rs943904344 1126 dbSNP
rs1460126538 1129 dbSNP
rs1438812418 1141 dbSNP
rs906817116 1142 dbSNP
rs1201060658 1145 dbSNP
rs1003168419 1154 dbSNP
rs1257621625 1160 dbSNP
rs1225167292 1163 dbSNP
rs929729984 1180 dbSNP
rs1033312152 1183 dbSNP
rs1380089282 1184 dbSNP
rs1236813861 1186 dbSNP
rs1396043050 1187 dbSNP
rs1403742161 1189 dbSNP
rs959086469 1193 dbSNP
rs577514273 1201 dbSNP
rs1463076248 1205 dbSNP
rs1184262802 1211 dbSNP
rs1170852119 1212 dbSNP
rs989207980 1215 dbSNP
rs374260168 1216 dbSNP
rs11330684 1231 dbSNP
rs869174465 1231 dbSNP
rs79202051 1232 dbSNP
rs1384800564 1235 dbSNP
rs77260356 1236 dbSNP
rs888120319 1237 dbSNP
rs1169928631 1238 dbSNP
rs937536675 1239 dbSNP
rs1482668383 1246 dbSNP
rs7290117 1247 dbSNP
rs1410262023 1248 dbSNP
rs978370190 1253 dbSNP
rs895975961 1256 dbSNP
rs745700752 1258 dbSNP
rs745418557 1270 dbSNP
rs1341966311 1273 dbSNP
rs1326246157 1296 dbSNP
rs185118125 1297 dbSNP
rs1020346808 1299 dbSNP
rs879209388 1302 dbSNP
rs866995224 1303 dbSNP
rs2179129 1314 dbSNP
rs1000246149 1321 dbSNP
rs1032937483 1335 dbSNP
rs1164256127 1344 dbSNP
rs953419691 1345 dbSNP
rs944629188 1351 dbSNP
rs1181143184 1353 dbSNP
rs1472969942 1354 dbSNP
rs137858476 1359 dbSNP
rs1489856996 1359 dbSNP
rs796077990 1359 dbSNP
rs965224198 1359 dbSNP
rs976721793 1362 dbSNP
rs1210257842 1369 dbSNP
rs976968811 1374 dbSNP
rs1277434970 1379 dbSNP
rs1339432907 1383 dbSNP
rs190306994 1398 dbSNP
rs1350575196 1403 dbSNP
rs1290691207 1409 dbSNP
rs1403621832 1410 dbSNP
rs1445337179 1412 dbSNP
rs921286790 1414 dbSNP
rs951076336 1414 dbSNP
rs1271513878 1423 dbSNP
rs1158739607 1424 dbSNP
rs983872601 1425 dbSNP
rs932664999 1429 dbSNP
rs1048496628 1430 dbSNP
rs909546380 1437 dbSNP
rs1197447867 1443 dbSNP
rs1479399801 1444 dbSNP
rs1256614633 1449 dbSNP
rs1246104761 1460 dbSNP
rs1199247159 1464 dbSNP
rs181187217 1465 dbSNP
rs1281619812 1466 dbSNP
rs1329501795 1467 dbSNP
rs1204936290 1471 dbSNP
rs1221195000 1472 dbSNP
rs1367485653 1480 dbSNP
rs1275982683 1485 dbSNP
rs1438997809 1493 dbSNP
rs141618340 1495 dbSNP
rs1056035201 1499 dbSNP
rs1320376004 1501 dbSNP
rs917511205 1502 dbSNP
rs775056470 1506 dbSNP
rs1195427821 1517 dbSNP
rs950346736 1527 dbSNP
rs200424365 1530 dbSNP
rs1414000613 1533 dbSNP
rs1037607682 1535 dbSNP
rs1192633950 1539 dbSNP
rs1424328961 1545 dbSNP
rs1173095614 1557 dbSNP
rs1478854763 1557 dbSNP
rs34605658 1563 dbSNP
rs906748866 1571 dbSNP
rs111499659 1574 dbSNP
rs1187769044 1574 dbSNP
rs1465042635 1581 dbSNP
rs552661003 1582 dbSNP
rs1470911767 1592 dbSNP
rs370427115 1596 dbSNP
rs563892871 1598 dbSNP
rs1054695509 1600 dbSNP
rs1221427580 1601 dbSNP
rs1338095007 1603 dbSNP
rs1177136867 1604 dbSNP
rs1436347060 1611 dbSNP
rs894796264 1613 dbSNP
rs1367562390 1615 dbSNP
rs1335009096 1619 dbSNP
rs1447301937 1626 dbSNP
rs1359830522 1634 dbSNP
rs1401425036 1635 dbSNP
rs889104741 1639 dbSNP
rs749608242 1647 dbSNP
rs1412201741 1648 dbSNP
rs1416097321 1648 dbSNP
rs1007997222 1652 dbSNP
rs1018964745 1662 dbSNP
rs1391586241 1665 dbSNP
rs537130881 1671 dbSNP
rs1179755440 1677 dbSNP
rs1482609233 1679 dbSNP
rs1319751204 1690 dbSNP
rs1237550691 1696 dbSNP
rs1326603101 1696 dbSNP
rs781609617 1700 dbSNP
rs1399056771 1712 dbSNP
rs146202243 1713 dbSNP
rs546482157 1722 dbSNP
rs1344765715 1730 dbSNP
rs1313116407 1742 dbSNP
rs1227947789 1743 dbSNP
rs1025858488 1744 dbSNP
rs1285999174 1747 dbSNP
rs1224525350 1751 dbSNP
rs1368574707 1755 dbSNP
rs951232679 1757 dbSNP
rs983864091 1774 dbSNP
rs568041311 1775 dbSNP
rs1255856094 1790 dbSNP
rs1162513991 1791 dbSNP
rs774104798 1807 dbSNP
rs966865123 1814 dbSNP
rs1183051601 1817 dbSNP
rs1206927135 1820 dbSNP
rs991537510 1822 dbSNP
rs535414980 1826 dbSNP
rs999334201 1827 dbSNP
rs1484356189 1830 dbSNP
rs1264044146 1831 dbSNP
rs1019208274 1832 dbSNP
rs1191854293 1834 dbSNP
rs550272088 1837 dbSNP
rs1222102848 1844 dbSNP
rs1349952258 1854 dbSNP
rs568854667 1865 dbSNP
rs1287577422 1875 dbSNP
rs539112597 1878 dbSNP
rs1352306525 1883 dbSNP
rs1291554344 1885 dbSNP
rs1260744356 1889 dbSNP
rs1042013117 1893 dbSNP
rs1245263535 1900 dbSNP
rs1166481097 1911 dbSNP
rs1455135074 1918 dbSNP
rs965967056 1924 dbSNP
rs974642036 1929 dbSNP
rs1265941988 1930 dbSNP
rs1489027552 1936 dbSNP
rs921876963 1937 dbSNP
rs1207067807 1942 dbSNP
rs186556957 1943 dbSNP
rs1268822907 1945 dbSNP
rs984158487 1950 dbSNP
rs1318607263 1955 dbSNP
rs1159763678 1956 dbSNP
rs889176093 1957 dbSNP
rs1007657455 1971 dbSNP
rs1040743953 1973 dbSNP
rs1883198 1977 dbSNP
rs187981926 1978 dbSNP
rs142484447 1982 dbSNP
rs1175978401 1983 dbSNP
rs1025600682 1995 dbSNP
rs575246008 1996 dbSNP
rs767110721 1997 dbSNP
rs939545084 2011 dbSNP
rs536546395 2012 dbSNP
rs1005411012 2026 dbSNP
rs1254113411 2028 dbSNP
rs542529019 2040 dbSNP
rs1405894848 2041 dbSNP
rs116544893 2047 dbSNP
rs991260535 2053 dbSNP
rs1024390073 2054 dbSNP
rs4823006 2062 dbSNP
rs766393758 2069 dbSNP
rs1399447335 2080 dbSNP
rs1301811457 2096 dbSNP
rs1466997980 2100 dbSNP
rs1379935029 2103 dbSNP
rs1280201518 2106 dbSNP
rs1353146818 2108 dbSNP
rs902231953 2114 dbSNP
rs1167050263 2115 dbSNP
rs1449280048 2128 dbSNP
rs1294140963 2130 dbSNP
rs978066042 2134 dbSNP
rs377001184 2144 dbSNP
rs1490584175 2145 dbSNP
rs1190770361 2147 dbSNP
rs1440966507 2156 dbSNP
rs1255557696 2157 dbSNP
rs370363094 2164 dbSNP
rs1018722072 2167 dbSNP
rs1436962175 2178 dbSNP
rs184219298 2182 dbSNP
rs11913197 2183 dbSNP
rs1341201346 2183 dbSNP
rs3208800 2184 dbSNP
rs1028913272 2185 dbSNP
rs112352251 2187 dbSNP
rs74449985 2187 dbSNP
rs138835675 2193 dbSNP
rs951943474 2196 dbSNP
rs984086391 2197 dbSNP
rs1449788758 2200 dbSNP
rs59463566 2201 dbSNP
rs182339307 2203 dbSNP
rs1429453871 2207 dbSNP
rs1170947713 2215 dbSNP
rs1368165091 2216 dbSNP
rs528247899 2231 dbSNP
rs909885459 2232 dbSNP
rs180799948 2238 dbSNP
rs1040500541 2240 dbSNP
rs961458842 2242 dbSNP
rs1275080642 2248 dbSNP
rs1197375287 2250 dbSNP
rs1353766199 2253 dbSNP
rs561561247 2266 dbSNP
rs1244802777 2271 dbSNP
rs1386650740 2272 dbSNP
rs928099865 2281 dbSNP
rs13055677 2282 dbSNP
rs550852302 2284 dbSNP
rs990986927 2297 dbSNP
rs916797459 2298 dbSNP
rs150694537 2303 dbSNP
rs1005484642 2312 dbSNP
rs1390233849 2321 dbSNP
rs1376820703 2323 dbSNP
rs1164054556 2328 dbSNP
rs1238005203 2334 dbSNP
rs1043374741 2337 dbSNP
rs1382821538 2343 dbSNP
rs539457677 2344 dbSNP
rs894350023 2348 dbSNP
rs1360411505 2349 dbSNP
rs1244423796 2353 dbSNP
rs115252587 2354 dbSNP
rs935043159 2359 dbSNP
rs1252508755 2362 dbSNP
rs1487349170 2367 dbSNP
rs1040521549 2378 dbSNP
rs971454731 2380 dbSNP
rs562465521 2395 dbSNP
rs1238668376 2404 dbSNP
rs1457277060 2407 dbSNP
rs901634578 2408 dbSNP
rs1031311919 2420 dbSNP
rs753735903 2422 dbSNP
rs566601458 2426 dbSNP
rs1330898908 2427 dbSNP
rs1324686294 2429 dbSNP
rs1443368567 2439 dbSNP
rs1163711543 2447 dbSNP
rs1158489827 2456 dbSNP
rs754739821 2464 dbSNP
rs185247029 2469 dbSNP
rs990365336 2470 dbSNP
rs1160244419 2471 dbSNP
rs1477035827 2481 dbSNP
rs1376852453 2483 dbSNP
rs11403703 2485 dbSNP
rs1207506840 2485 dbSNP
rs1245842211 2485 dbSNP
rs397797317 2485 dbSNP
rs397825648 2485 dbSNP
rs1164293320 2490 dbSNP
rs1286886870 2496 dbSNP
rs74778781 2497 dbSNP
rs1366369736 2498 dbSNP
rs1345002501 2499 dbSNP
rs1463792755 2499 dbSNP
rs910717102 2500 dbSNP
rs1400147970 2503 dbSNP
rs1445281885 2506 dbSNP
rs1338746978 2511 dbSNP
rs1383694067 2512 dbSNP
rs545017603 2521 dbSNP
rs1395539612 2532 dbSNP
rs887664445 2536 dbSNP
rs1320150391 2541 dbSNP
rs139986632 2542 dbSNP
rs1347031380 2543 dbSNP
rs558571952 2544 dbSNP
rs961661443 2571 dbSNP
rs575001338 2573 dbSNP
rs535728216 2574 dbSNP
rs1387862979 2588 dbSNP
rs1187552029 2589 dbSNP
rs1317187774 2589 dbSNP
rs1196748528 2595 dbSNP
rs1047729959 2597 dbSNP
rs1035512013 2598 dbSNP
rs1442323003 2606 dbSNP
rs941216783 2621 dbSNP
rs557644097 2629 dbSNP
rs990919891 2630 dbSNP
rs1194817444 2634 dbSNP
rs1229410986 2635 dbSNP
rs575453673 2651 dbSNP
rs946910734 2653 dbSNP
rs980080776 2660 dbSNP
rs1358465668 2661 dbSNP
rs924252195 2668 dbSNP
rs4823007 2669 dbSNP
rs1360253810 2670 dbSNP
rs5762962 2672 dbSNP
rs572967279 2674 dbSNP
rs1410148552 2676 dbSNP
rs1421266551 2681 dbSNP
rs1364318780 2695 dbSNP
rs4823008 2701 dbSNP
rs1258764501 2702 dbSNP
rs1190682707 2708 dbSNP
rs1011774969 2714 dbSNP
rs1050227146 2717 dbSNP
rs1274333702 2722 dbSNP
rs887589514 2723 dbSNP
rs1339664576 2730 dbSNP
rs965223397 2731 dbSNP
rs190804823 2732 dbSNP
rs1416539502 2737 dbSNP
rs1348599981 2744 dbSNP
rs1015247151 2745 dbSNP
rs983536262 2759 dbSNP
rs1355878175 2760 dbSNP
rs145473021 2769 dbSNP
rs544167373 2770 dbSNP
rs1166526255 2773 dbSNP
rs1471884277 2790 dbSNP
rs1038277403 2803 dbSNP
rs1178101102 2806 dbSNP
rs562846492 2808 dbSNP
rs1034998079 2809 dbSNP
rs915808410 2811 dbSNP
rs948659125 2817 dbSNP
rs1221091478 2826 dbSNP
rs1045534133 2831 dbSNP
rs879427708 2836 dbSNP
rs1326926333 2837 dbSNP
rs58582319 2852 dbSNP
rs183405122 2855 dbSNP
rs1375245034 2856 dbSNP
rs1023704564 2859 dbSNP
rs968615659 2865 dbSNP
rs1291638388 2866 dbSNP
rs1052834199 2868 dbSNP
rs566492534 2870 dbSNP
rs1327273496 2871 dbSNP
rs979665444 2872 dbSNP
rs1011219194 2873 dbSNP
rs1421455317 2878 dbSNP
rs1017706571 2884 dbSNP
rs964959159 2885 dbSNP
rs186595948 2898 dbSNP
rs1202081763 2902 dbSNP
rs549103044 2903 dbSNP
rs1255150606 2911 dbSNP
rs756566455 2919 dbSNP
rs1260013080 2926 dbSNP
rs1239676617 2928 dbSNP
rs1030457952 2930 dbSNP
rs956987574 2935 dbSNP
rs1173998848 2936 dbSNP
rs1347102655 2937 dbSNP
rs1420528691 2942 dbSNP
rs1305185640 2947 dbSNP
rs775181042 2953 dbSNP
rs75967761 2955 dbSNP
rs1358872372 2958 dbSNP
rs983523294 2966 dbSNP
rs760318327 2969 dbSNP
rs1289008607 2987 dbSNP
rs780541950 2988 dbSNP
rs1276421455 2997 dbSNP
rs931657198 3014 dbSNP
rs536417678 3019 dbSNP
rs749788843 3029 dbSNP
rs1175736698 3030 dbSNP
rs1218618739 3047 dbSNP
rs1397046705 3048 dbSNP
rs2294241 3052 dbSNP
rs569566370 3072 dbSNP
rs1262480662 3075 dbSNP
rs1240245816 3086 dbSNP
rs1036200783 3087 dbSNP
rs149141007 3089 dbSNP
rs1002810819 3091 dbSNP
rs1225153324 3092 dbSNP
rs570045048 3093 dbSNP
rs1209807518 3119 dbSNP
rs774904433 3119 dbSNP
rs1305430372 3121 dbSNP
rs1057002419 3122 dbSNP
rs1190034413 3123 dbSNP
rs1410823641 3126 dbSNP
rs1225720183 3141 dbSNP
rs1440327923 3145 dbSNP
rs934522257 3146 dbSNP
rs1383434022 3150 dbSNP
rs1377571081 3154 dbSNP
rs1302779557 3155 dbSNP
rs1052783998 3158 dbSNP
rs896478281 3159 dbSNP
rs1158157925 3161 dbSNP
rs892864861 3170 dbSNP
rs1012239331 3175 dbSNP
rs1195371988 3179 dbSNP
rs747768261 3181 dbSNP
rs1011292502 3191 dbSNP
rs1023674902 3192 dbSNP
rs1378649748 3194 dbSNP
rs1202818113 3195 dbSNP
rs1338284498 3205 dbSNP
rs1426846410 3206 dbSNP
rs1251562120 3207 dbSNP
rs1228887259 3210 dbSNP
rs1319415934 3221 dbSNP
rs900168022 3228 dbSNP
rs115669003 3241 dbSNP
rs572904269 3244 dbSNP
rs540286023 3245 dbSNP
rs555868257 3246 dbSNP
rs1005033541 3249 dbSNP
rs957150521 3268 dbSNP
rs1379064340 3276 dbSNP
rs560369394 3280 dbSNP
rs544421976 3282 dbSNP
rs1165799058 3284 dbSNP
rs1351007478 3287 dbSNP
rs771912706 3288 dbSNP
rs1437021174 3292 dbSNP
rs985832006 3294 dbSNP
rs191887929 3295 dbSNP
rs1291016840 3315 dbSNP
rs991315451 3317 dbSNP
rs1219836518 3318 dbSNP
rs941798008 3327 dbSNP
rs1458626561 3329 dbSNP
rs1036582529 3343 dbSNP
rs919079398 3344 dbSNP
rs971171998 3350 dbSNP
rs938543552 3355 dbSNP
rs1336714967 3370 dbSNP
rs1056969936 3371 dbSNP
rs1385272819 3375 dbSNP
rs1394082984 3377 dbSNP
rs1326599300 3383 dbSNP
rs894438166 3385 dbSNP
rs1463104625 3393 dbSNP
rs1178078065 3394 dbSNP
rs1156755907 3396 dbSNP
rs533222314 3402 dbSNP
rs1364154092 3403 dbSNP
rs772581014 3406 dbSNP
rs1236478951 3409 dbSNP
rs1012164348 3412 dbSNP
rs753361980 3415 dbSNP
rs545346035 3417 dbSNP
rs3178915 3418 dbSNP
rs1205059067 3421 dbSNP
rs1000974584 3434 dbSNP
rs988575165 3435 dbSNP
rs1231556161 3439 dbSNP
rs1304442210 3442 dbSNP
rs914411307 3442 dbSNP
rs1443118459 3445 dbSNP
rs577560116 3448 dbSNP
rs113063808 3451 dbSNP
rs770354213 3457 dbSNP
rs1400009354 3460 dbSNP
rs1385610835 3463 dbSNP
rs1160046607 3464 dbSNP
rs1452346100 3477 dbSNP
rs900156372 3482 dbSNP
rs1193869181 3486 dbSNP
rs956879750 3495 dbSNP
rs933006057 3503 dbSNP
rs997718224 3508 dbSNP
rs886663967 3514 dbSNP
rs1030584737 3519 dbSNP
rs953613303 3529 dbSNP
rs114981975 3533 dbSNP
rs750300317 3534 dbSNP
rs1363336705 3541 dbSNP
rs5752860 3542 dbSNP
rs113010896 3544 dbSNP
rs963397926 3562 dbSNP
rs1431615336 3564 dbSNP
rs182810865 3570 dbSNP
rs1012326452 3573 dbSNP
rs1284358764 3574 dbSNP
rs1374626029 3581 dbSNP
rs1174074834 3582 dbSNP
rs12321 3584 dbSNP
rs1416971806 3588 dbSNP
rs188226810 3591 dbSNP
rs992625296 3593 dbSNP
rs970733784 3597 dbSNP
rs915797949 3600 dbSNP
rs948653651 3608 dbSNP
rs1244274551 3612 dbSNP
rs982496330 3630 dbSNP
rs1457968125 3644 dbSNP
rs1030973913 3654 dbSNP
rs955920328 3660 dbSNP
rs1340254769 3666 dbSNP
rs1226918174 3677 dbSNP
rs1272569819 3699 dbSNP
rs529445572 3717 dbSNP
rs1319174919 3722 dbSNP
rs1045018864 3724 dbSNP
rs1341545717 3741 dbSNP
rs903831316 3743 dbSNP
rs1198645945 3745 dbSNP
rs1282570058 3750 dbSNP
rs936695362 3751 dbSNP
rs1052521011 3758 dbSNP
rs1313208531 3764 dbSNP
rs1256221483 3770 dbSNP
rs892583916 3782 dbSNP
rs1352334972 3786 dbSNP
rs60214892 3800 dbSNP
rs191941463 3803 dbSNP
rs1169321147 3813 dbSNP
rs1410239700 3814 dbSNP
rs569372422 3825 dbSNP
rs1188369782 3826 dbSNP
rs1030512644 3828 dbSNP
rs1258866327 3831 dbSNP
rs1232723658 3833 dbSNP
rs3215453 3833 dbSNP
rs397708299 3833 dbSNP
rs76221730 3833 dbSNP
rs869136813 3833 dbSNP
rs1471960010 3847 dbSNP
rs1439822713 3855 dbSNP
rs1287788118 3857 dbSNP
rs889342414 3858 dbSNP
rs1240753591 3860 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions TZM-bl
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM1462574. RNA binding protein: AGO2. Condition:TZM-bl ami BaL ...

- Whisnant AW; Bogerd HP; Flores O; Ho P; et al., 2013, mBio.

Article - Whisnant AW; Bogerd HP; Flores O; Ho P; et al.
- mBio, 2013
UNLABELLED: The question of how HIV-1 interfaces with cellular microRNA (miRNA) biogenesis and effector mechanisms has been highly controversial. Here, we first used deep sequencing of small RNAs present in two different infected cell lines (TZM-bl and C8166) and two types of primary human cells (CD4(+) peripheral blood mononuclear cells [PBMCs] and macrophages) to unequivocally demonstrate that HIV-1 does not encode any viral miRNAs. Perhaps surprisingly, we also observed that infection of T cells by HIV-1 has only a modest effect on the expression of cellular miRNAs at early times after infection. Comprehensive analysis of miRNA binding to the HIV-1 genome using the photoactivatable ribonucleoside-induced cross-linking and immunoprecipitation (PAR-CLIP) technique revealed several binding sites for cellular miRNAs, a subset of which were shown to be capable of mediating miRNA-mediated repression of gene expression. However, the main finding from this analysis is that HIV-1 transcripts are largely refractory to miRNA binding, most probably due to extensive viral RNA secondary structure. Together, these data demonstrate that HIV-1 neither encodes viral miRNAs nor strongly influences cellular miRNA expression, at least early after infection, and imply that HIV-1 transcripts have evolved to avoid inhibition by preexisting cellular miRNAs by adopting extensive RNA secondary structures that occlude most potential miRNA binding sites. IMPORTANCE: MicroRNAs (miRNAs) are a ubiquitous class of small regulatory RNAs that serve as posttranscriptional regulators of gene expression. Previous work has suggested that HIV-1 might subvert the function of the cellular miRNA machinery by expressing viral miRNAs or by dramatically altering the level of cellular miRNA expression. Using very sensitive approaches, we now demonstrate that neither of these ideas is in fact correct. Moreover, HIV-1 transcripts appear to largely avoid regulation by cellular miRNAs by adopting an extensive RNA secondary structure that occludes the ability of cellular miRNAs to interact with viral mRNAs. Together, these data suggest that HIV-1, rather than seeking to control miRNA function in infected cells, has instead evolved a mechanism to become largely invisible to cellular miRNA effector mechanisms.
LinkOut: [PMID: 23592263]
Experimental Support 2 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HCT116
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in ERX177613. RNA binding protein: AGO2. Condition:KO_D_AGO_CLIP_3_3 PAR-CLIP data was present in ERX177624. RNA binding protein: AGO2. Condition:p53_V_AGO_CLIP_4_2 ...

- Krell J; Stebbing J; Carissimi C; Dabrowska et al., 2016, Genome research.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' ucgGGA---ACGGUAG-GAC-CAGGug 5'
             |||   ||| | | |||  |||  
Target 5' ucaCCUCACUGCAACCUCUGCCUCCcg 3'
 		4 - 30
Article - Krell J; Stebbing J; Carissimi C; Dabrowska et al.
- Genome research, 2016
DNA damage activates TP53-regulated surveillance mechanisms that are crucial in suppressing tumorigenesis. TP53 orchestrates these responses directly by transcriptionally modulating genes, including microRNAs (miRNAs), and by regulating miRNA biogenesis through interacting with the DROSHA complex. However, whether the association between miRNAs and AGO2 is regulated following DNA damage is not yet known. Here, we show that, following DNA damage, TP53 interacts with AGO2 to induce or reduce AGO2's association of a subset of miRNAs, including multiple let-7 family members. Furthermore, we show that specific mutations in TP53 decrease rather than increase the association of let-7 family miRNAs, reducing their activity without preventing TP53 from interacting with AGO2. This is consistent with the oncogenic properties of these mutants. Using AGO2 RIP-seq and PAR-CLIP-seq, we show that the DNA damage-induced increase in binding of let-7 family members to the RISC complex is functional. We unambiguously determine the global miRNA-mRNA interaction networks involved in the DNA damage response, validating them through the identification of miRNA-target chimeras formed by endogenous ligation reactions. We find that the target complementary region of the let-7 seed tends to have highly fixed positions and more variable ones. Additionally, we observe that miRNAs, whose cellular abundance or differential association with AGO2 is regulated by TP53, are involved in an intricate network of regulatory feedback and feedforward circuits. TP53-mediated regulation of AGO2-miRNA interaction represents a new mechanism of miRNA regulation in carcinogenesis.
LinkOut: [PMID: 26701625]
CLIP-seq Support 1 for dataset GSM4903829
Method / RBP HITS-CLIP / AGO
Cell line / Condition Human neurons / CTLTD_shCTL_a
Location of target site NM_032173 | 3UTR | GUCCAAGUGAUUCUCCU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161238
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM4903833
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / CTL_TD_21_a
Location of target site NM_001206998 | 3UTR | CCUCCCGGGUCCAAGUGAUUCUCCUGCCUCAGCCUCCCAAGUAGCUGGGAUUACAGGCAUGCGCCACCACACCCAGCUAAUUUUGUAUUUUUGGUAGAGACAGG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 3 for dataset GSM4903834
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / CTL_TD_21_b
Location of target site NM_032173 | 3UTR | CCCGGGUCCAAGUGAUUCUCCUGCCUCAGCCUCCCAAGUAGCUGGGAUUACAGGCAU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 4 for dataset GSM4903835
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / CTL_TD_21_c
Location of target site NM_032173 | 3UTR | CAAGUGAUUCUCCUGCCUCAGCCUCCCAAGUAGCUGGGAUUACAGGCAU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 5 for dataset GSM4903836
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / 124_TD_21_a
Location of target site NM_032173 | 3UTR | CCAAGUGAUUCUCCUGCCUCAGCCUCCCAAGUAGCUGGGAUUACAGGCAU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 6 for dataset GSM4903837
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / 124_TD_21_b
Location of target site NM_032173 | 3UTR | CGGGUCCAAGUGAUUCUCCUGCCUCAGCCUCCCAAGUAGCUGGGAUUACAGGCAU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 7 for dataset GSM4903838
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / 124_TD_21_c
Location of target site NM_032173 | 3UTR | UCCAAGUGAUUCUCCUGCCUCAGCCUCCCAAGUAGCUGGGAUUACAGGCAUGCGCCACC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 8 for dataset GSM1462574
Method / RBP PAR-CLIP / AGO2
Cell line / Condition TZM-bl / TZM-bl ami BaL
Location of target site ENST00000544604.2 | 3UTR | CAAUGGCGCGAUCUCACCUCACUGCAACCUCUGCCUCCCGGGUCCAAGUGAUUCUCCUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23592263 / GSE59944
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
30 hsa-miR-4776-5p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT303862 MAT2A methionine adenosyltransferase 2A 2 4
MIRT445702 OGT O-linked N-acetylglucosamine (GlcNAc) transferase 2 4
MIRT451664 KRT8 keratin 8 2 4
MIRT456718 TMEM239 transmembrane protein 239 2 2
MIRT462899 ZNRF3 zinc and ring finger 3 2 2
MIRT469058 RNF20 ring finger protein 20 2 2
MIRT476392 GDE1 glycerophosphodiester phosphodiesterase 1 2 8
MIRT477147 FADS1 fatty acid desaturase 1 2 8
MIRT479187 CLCN5 chloride voltage-gated channel 5 2 6
MIRT480935 BBX BBX, HMG-box containing 2 8
MIRT496801 WNT2B Wnt family member 2B 2 2
MIRT503537 SNTN sentan, cilia apical structure protein 2 4
MIRT507648 CREBRF CREB3 regulatory factor 2 4
MIRT507918 C2orf72 chromosome 2 open reading frame 72 2 4
MIRT510817 SBNO1 strawberry notch homolog 1 2 4
MIRT523221 HIST1H3A histone cluster 1 H3 family member a 2 2
MIRT529829 ARGFX arginine-fifty homeobox 2 2
MIRT532355 SLC1A4 solute carrier family 1 member 4 2 2
MIRT532401 RAB44 RAB44, member RAS oncogene family 2 2
MIRT535409 PDZD8 PDZ domain containing 8 2 2
MIRT566060 RCC2 regulator of chromosome condensation 2 2 2
MIRT571239 FADS6 fatty acid desaturase 6 2 2
MIRT611144 TNRC6B trinucleotide repeat containing 6B 2 4
MIRT621399 PYCRL pyrroline-5-carboxylate reductase 3 2 2
MIRT647404 SSTR3 somatostatin receptor 3 2 2
MIRT654033 SAMD12 sterile alpha motif domain containing 12 2 2
MIRT659428 COL1A1 collagen type I alpha 1 chain 2 2
MIRT662068 ZNF284 zinc finger protein 284 2 2
MIRT663830 AGBL5 ATP/GTP binding protein like 5 2 4
MIRT699963 RREB1 ras responsive element binding protein 1 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-4776-5p Temozolomide 5394 NSC362856 approved sensitive cell line (U251)
hsa-miR-4776-5p Cisplatin 5460033 NSC119875 approved sensitive cell line (CAL-27) (mitochondrial RNA)
hsa-miR-4776-5p Osimertinib 71496458 NSC779217 approved resistant cell line (H1975)
hsa-miR-4776-5p Gemcitabine 60750 NSC613327 approved sensitive cell line (PANC-1) (100 ng/ml)
hsa-miR-4776-5p Gemcitabine 60750 NSC613327 approved sensitive cell line (PANC-1) (1500 ng/ml)

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