miRTarBase - #MIRT463119


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pre-miRNA Information
pre-miRNA hsa-mir-605   
Genomic Coordinates chr10: 51299573 - 51299655
Synonyms MIRN605, hsa-mir-605, MIR605
Description Homo sapiens miR-605 stem-loop
Comment None
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-605-5p
Sequence 16| UAAAUCCCAUGGUGCCUUCUCCU |38
Evidence Experimental
Experiments SAGE
Editing Events in miRNAs
Modification Type Position on miR Chromosome DNA Strand Genomic Position (hg38) List of PMIDs Variant details
A-to-I 3 10 + 51299590 29233923, 28550310 MiREDiBase
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs113212828 2 dbSNP
rs1265154909 7 dbSNP
rs76759855 9 dbSNP
rs1032735304 10 dbSNP
rs1318073696 10 dbSNP
rs1486056689 11 dbSNP
rs1225930966 12 dbSNP
rs1011066926 14 dbSNP
rs1261327694 19 dbSNP
rs1020985018 22 dbSNP
rs1426923077 22 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol ZNF507   
Synonyms -
Description zinc finger protein 507
Transcript NM_001136156   
Other Transcripts NM_014910   
Expression
Putative miRNA Targets on ZNF507
3'UTR of ZNF507
(miRNA target sites are highlighted)		 
>ZNF507|NM_001136156|3'UTR
   1 GTGGAATAATGACTCGAGCAGGAAAGCAGTAGAAGAGGATTCCTTCACCACAGTTTCACCTTTACGCTGTCAGACAACTT
  81 CCTGCCACAGAAGAAGTCGTTGATGTGATTTTTGAGGAAATGACAGATGTGACTTTGGAACCAAACTTGTAATAAAAGGA
 161 ATTCCAAATGGACAAGCAGTAATGATATTTAAATATTTTGAGTGAGGGGGAGTGGGTCAAAGAGGAAGTAGAGGTGTAAT
 241 CCTGTATTAACCCTCTGTCACCCCTTCTTAGTGTCGAGTGTATTTATTAATAAAAGCTTATTAGAGTGTAGAAATGCCAG
 321 CAAGAGTTAAGAAAGGGCTTTTCAGGAACTATTCTAAAAGTCATAAAAGGGTCACAGTCTTAAGCAGAGCTTAGTTTTCT
 401 TCTCACTTGTCAAATGCAGACTGTGAGGCCTCCAGTGAGAAATGGGAGGCAGTTCTGGGAGGGGGTTTTTTCAGTGTCAC
 481 CAACAGAGTCAACAAGGAAACATAATTAGAGGGCTTTGAAATGATCTACTGAAATACCTAAATTGATAGAAATTAATCAT
 561 ACTCAATCTAGGACATGTTCCTTTACTCCTTAAAAAAGAAAGGAAAGATCTCTAAATTCAAAGCTAGATTGTAAATAGGC
 641 ATTCAAGAAGTATTGTCTTAAATTTACGATGAATTTCTTGTGAGCAGAGGACGAAACAGGTGAATTCTCACCAGACTCAA
 721 ACCAGATCTCAATTCGTAGTAATGCTAAATCGTCTTCCGTGTTCTCAGAGGTTCTTTTCAGTGTCTGTCAGAACTTGGCA
 801 TACTTTCTCCATAGTACGTAGACCTTCTAATACTCTGCTAAATGAAACCACACTTGTTATCTGAAAGTGTGTGAAAGAAA
 881 CAATGTATGAAAATTTACATTTGATCATCCGGCATTGGAAATAGTTTGAACTATTTCCAAAAATCCCTTAGGGGATGAGG
 961 GGTGAAATTTAAAAGCTCCTGAAAATGAGTACTGCTGTGTTGAGCTTTTCTTTCCTGGGGTATATTAATTTAGTTATATT
1041 TAGCAGAAGAGGAATATAACCAAATGTGACTAAAATATAGCAGAAATTCAGGTTGTTTGTAAAAATTTTAATAACAAATA
1121 GCATTTGGCAAGTCTATAGGATTCTTCCTATCTGGAAATTCTATTTTGTTAGAGTGCGATAGGACATATGGAAAACCAAC
1201 ACAAAGTGCTTTAGCATTAAAACTCACCATCAAATAGATGTAATCTTATTAATTACACATTTTGTATTTTAATTATTTCA
1281 AGGAGTGAAGAAAACAGGGTGTTTTTGTTTTTGTAGTTCTGATTACTCATTTATGCATTGTTTTGTTTAAGTAAATTCTG
1361 CCTACAAGTGAAAAGGTCGGTGCGCTCTTCTGTGCACCATCCTCACGGTGCTATTTCCGAATATCTGAATATTGATTTCT
1441 AACACCTGGATGAGGCTGTGACCGATCAACTTGGAACACTGTAAAGGTTTTCGAATGGGATACGCTGTAGGCACGTTTTA
1521 AGAAGTATTCTGTTCCTAAAGTCCAGGTATGATTGGATTAATATTTATAAAATTATTATTAGGAATTATTTAAGTGGGGC
1601 CAGGCATCTTGCAACATTTTCTGATTTTTTTTTCTTTCTTTCTAATCTCATTTTGGTGATATTTAAACAAACATAAATGA
1681 TTGTAACTTTGCAGCTTTTTTATTTAGGTAGCTTTAATTTATTTATGAAAGTTAATCCATTTCTGATACGTGGTTTTTAA
1761 AAATATGAAATGGATTTATATATACTATATTCCTCAAATCCACTGTATGTGGACTTATATTCATTTTCTCCTTTTTTCGG
1841 AATTGAAACATTTTAATTTCAAATTCAAATAGAACATTTAAAATGATTTCATTATTATTACCCATACTGTTGCCACTCAT
1921 ATTGTAAGTCAGTTTTTTCATTGCTGGTACAATGACTCAGTATTTCTTTATAAAAATCTGTTGTTCTGAAAATCAACAAC
2001 CTTAGAAGGATTTTGTCTTAGAAAATTTCCTTGGCTTTAGTTTTATATCATATTTAGAAAATAATAATGAAAAGCATCCC
2081 CAAAATTTCAATGATGTGAATTTTTAAATTACCTTTATTTCTTTAAACTAATTCCATTGATTGTTACTTAAATTTTCCAC
2161 CTGGAATCATGGATTTAAAATTTCCCCACCTCATGGGGAAAAAACTAACCCAGAAGTTCAAAGCCTTTAAAGTTTCATCT
2241 GATTCTGGCCTTAGAATTGTCCTTAAAAGCTTTCTCCTGGCCGATAGGAGGAAGCATATATCAAGGAGGTTCTTTCCCTT
2321 CCCATTATCATTTTGTGGCAAGCCTTAAGTTAACAATGTGTCTACCAAGAACAATTGAGTTTTCTAAAAGTAATAATGAA
2401 GATTATGCAATTCTAACTGTAGAAGAGATAGCTATTAAAATAATCAGTAGCCTGGGCATAGTGGCTCACACCTGTAATCC
2481 CAATACTTTAGAAGGCCAAGGCTGGAGGACTGCTTGAGTCCAGAAGTTTAAGACCAGCCTGGGCAACACGGGGAGACCCT
2561 GTCTCTACAAGAAATTAAAAATTAGCCAGGCATAGTTGGCACGTGCCTGTAGCACCAGCTACTTGGGAGGTTAAGGTGGG
2641 AGGATCACTTGAGCCTGGGAGATAGAGGCTTGCAGTGAGCCGTGATGGCACCATTGCACTCCAACCGGGGTGACAGATGA
2721 GGTCCTCTGTTTACCTCCCCCCCCAAAAAAAAAATTCAGTAGGAATTCCTTCATAGAATAACATGTTATTTATTGGTATT
2801 GACTTCTTATTAGACAGAGCTCATAGTATTTGTTTTCTGCTCCGAACACTTAAAAAATACTAAGACGTGATAGTGAAAAT
2881 AGCTTTGAAAAGAAACTACATATGGCAAAGGTGGGGAGGGGGGAAGATGATGCATTCTGATCATTATAAAGAATACTTTT
2961 CAGGGCTCTATCATTTTCTCCCTTTCTCTAATCATCCAGAATATGGCGGGTGTCCCAGTGTTCAACAGTATCATGCTAAT
3041 ATTCCATTTGATCGGTAGTCCAAGTTCTTTGGCCAGATAGTGCAATGTTGTGACACCGACCGAAGCCTTTGTTCTGGATC
3121 TTTCTTCCTATTGAAGGTGGCTGCTGGTGGCTTCATAATTTTCTGTTTTTTTTCTCACAAAGTAAATGGTGGGCATCCAT
3201 GTTTACATTGCACCTTCCCGTGCTGTAATTGGCTTGACAAAGACAAGCAGGCTTCTCTGTTGAGACTTATTGTGTTTTTA
3281 GTTTTCATAGACACTTATTTAATCTTTTTAAATTGTACAGCAAGGTGCTCTAAGTAATATTCGATAAAATATATTTAATA
3361 GAAATTTGCGTTTGATATTCATGAACATGAATACATGTATTTTTTTAAGAAATAAGTATTGTGTAACACTATGGCATTGC
3441 TTCTATAGCCAAAGTATAAAAATTTCTGGAATACTGACATGTAAAGACTACAGTTAATTCTGACACTGTATCTTATTAAA
3521 ATAGGATGATTTGCATTTTGTAAAATTATCCTGCACATCAAGCTGCATGCCTTAAAGCGGAAACTCTAGGACTGTGTTCA
3601 TGGGAGAGCAGTTCATCTGTTCAGAACAGTGAGGCAAGGTCTGTAGTGCTTCTTTAACTACCTTTGGAAATACTGTACAA
3681 TGTTAGAATAATTTATTTTGCTTTACAGGAGTTTGTCATGTATTGACTTTAATATTGTATTTTGGTAATAAATTTTTTGT
3761 TAAAAAAAACTTGGCTCCAAGTTCTATTAACCACAGGTTGTGTTCATTCTTTTCCTGGAAATGATGACTTTATTGCTTAG
3841 AAAGTTGTAAATAATTAAAAGCTTCCCAAGAGTTAAATGAAGGTTATGATGACTCTTGATAACTTGTTAATCTGTTGCTG
3921 ACTAGCATTAGACTGTTACACGAAGATAAACTGAATAAGCATTTAGCTTTTTAAATCATTTTAAAAATTAAGTCTAATTT
4001 TGAAGCTTTTTTCCTTGCTACCCAGTTCAGTTTCTCTTCCAAATGTGACACGCTTATATGCTTTCAATTCTGATATAGTC
4081 AAAGTGCTAAAGACTAGTTCTGCTATTGACGAAGGAATTAGCATTCCTTAGTGAAGGCCAAAAACTACAGTGATATGTTC
4161 ACACCTTGATCACTCTGTCGTCTATACAGACAGCTATTGACATATTTGTTGCATTGACGAAGCTAACATCATCTGACTGT
4241 ATCGTGGGTCTGGTTATCCATTTGTGCCCTAGAATCCTGGGTCACCTCAGTTGAAAGTGACCAAGGCCAAATATTTCGTC
4321 CCATGCTTCCCAGGGACAACATAATCATATCCCCTGTCTTTGAAAAACCCAATCTGAAACTGTGTCACTAACCTCCAAAT
4401 TAAAGAATCCGAGCATGGAAGCTCTAGAACGTATGGTCCAGTGTGGCAGCCACTATAATATCTAAGTGTAAAATACATAG
4481 CAGTTGCAAAGACTTAGTACAAAAAGAATGGAAATGTATTAACAGTTTTTTATATTGATTACATGTTGAAATGATATTTT
4561 GGTTTAAATAAAATATTAAAATTAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' uccUCUUCCGUGG-UACCCUAAAu 5'
             ||||| |::: ||| ||||| 
Target 5' agaAGAAGTCGTTGATGTGATTTt 3'
 89 - 112 140.00 -12.60
2 
miRNA  3' uccUCUUCCGU---GG---UACCCUAAAu 5'
             :|:|||||   |:   | |||:||| 
Target 5' aatGGGAGGCAGTTCTGGGAGGGGGTTTt 3'
 441 - 469 140.00 -16.90
3 
miRNA  3' uccUCUUCCGUGGUA-------CCCUAAAu 5'
             | |||| | |||       ||| ||| 
Target 5' tcaACAAGGAAACATAATTAGAGGGCTTTg 3'
 489 - 518 124.00 -9.54
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30491894 4 COSMIC
COSN30498833 5 COSMIC
COSN31556461 9 COSMIC
COSN26465729 12 COSMIC
COSN30496077 16 COSMIC
COSN30709284 17 COSMIC
COSN31523798 25 COSMIC
COSN31612458 61 COSMIC
COSN20079396 67 COSMIC
COSN30165815 87 COSMIC
COSN30531683 88 COSMIC
COSN1214216 179 COSMIC
COSN27963467 304 COSMIC
COSN6142700 756 COSMIC
COSN26837249 1565 COSMIC
COSN20115690 1634 COSMIC
COSN1214217 1635 COSMIC
COSN1214218 1636 COSMIC
COSN9354863 1648 COSMIC
COSN20115696 1951 COSMIC
COSN4967599 2099 COSMIC
COSN5184299 2224 COSMIC
COSN31961538 3055 COSMIC
COSN31556213 3174 COSMIC
COSN31579366 3197 COSMIC
COSN28673671 3271 COSMIC
COSN21624445 3298 COSMIC
COSN24507238 3305 COSMIC
COSN22473490 3334 COSMIC
COSN31546513 3343 COSMIC
COSN1766422 3413 COSMIC
COSN20093570 3436 COSMIC
COSN26603943 3450 COSMIC
COSN24725089 3555 COSMIC
COSN31546508 3618 COSMIC
COSN26676817 3635 COSMIC
COSN29291113 3900 COSMIC
COSN27378303 4449 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs200305272 2 dbSNP
rs1201480683 5 dbSNP
rs1441218265 5 dbSNP
rs768769195 9 dbSNP
rs1427038551 14 dbSNP
rs774505328 16 dbSNP
rs762029958 17 dbSNP
rs367984378 23 dbSNP
rs1205888504 28 dbSNP
rs1466346530 29 dbSNP
rs772441937 31 dbSNP
rs770836106 38 dbSNP
rs886516168 60 dbSNP
rs1324163056 61 dbSNP
rs774312940 66 dbSNP
rs147487056 67 dbSNP
rs1224978386 77 dbSNP
rs1325601388 86 dbSNP
rs1295881259 89 dbSNP
rs753843468 89 dbSNP
rs1275570113 95 dbSNP
rs1336180988 96 dbSNP
rs745596836 98 dbSNP
rs532913645 99 dbSNP
rs114137801 100 dbSNP
rs1460350121 106 dbSNP
rs759501039 115 dbSNP
rs570289102 116 dbSNP
rs1174787802 126 dbSNP
rs769467160 131 dbSNP
rs1030566768 132 dbSNP
rs1372841545 142 dbSNP
rs529466393 149 dbSNP
rs189376279 153 dbSNP
rs1183083815 155 dbSNP
rs938890622 158 dbSNP
rs1166304302 178 dbSNP
rs565871292 178 dbSNP
rs1193956781 184 dbSNP
rs916141092 197 dbSNP
rs1421954789 205 dbSNP
rs948960914 206 dbSNP
rs1335814523 216 dbSNP
rs1230248834 223 dbSNP
rs768278 226 dbSNP
rs999167430 237 dbSNP
rs1380106045 238 dbSNP
rs1313835512 245 dbSNP
rs1452769256 247 dbSNP
rs1336770863 253 dbSNP
rs1341687109 253 dbSNP
rs1031202882 254 dbSNP
rs1390134189 258 dbSNP
rs534773250 260 dbSNP
rs1396307150 264 dbSNP
rs775163419 272 dbSNP
rs1043042623 276 dbSNP
rs957810110 277 dbSNP
rs73565340 279 dbSNP
rs1053239182 291 dbSNP
rs1437160055 308 dbSNP
rs559197590 317 dbSNP
rs1252343947 330 dbSNP
rs1271530128 335 dbSNP
rs571569439 343 dbSNP
rs1207042319 345 dbSNP
rs760306819 346 dbSNP
rs900985641 369 dbSNP
rs1339681668 379 dbSNP
rs1222570705 381 dbSNP
rs537413668 385 dbSNP
rs1277258887 386 dbSNP
rs1440719935 395 dbSNP
rs998006351 415 dbSNP
rs1321931786 422 dbSNP
rs1028127144 428 dbSNP
rs1412104456 429 dbSNP
rs969169836 431 dbSNP
rs1257488022 432 dbSNP
rs1406141365 443 dbSNP
rs763718771 453 dbSNP
rs1469639829 457 dbSNP
rs981996110 457 dbSNP
rs62104827 463 dbSNP
rs1478252356 466 dbSNP
rs1489812302 466 dbSNP
rs1267878207 467 dbSNP
rs1221930466 476 dbSNP
rs1452959488 483 dbSNP
rs1281624766 485 dbSNP
rs938713316 485 dbSNP
rs1222706706 496 dbSNP
rs972879870 498 dbSNP
rs555700208 502 dbSNP
rs960753900 518 dbSNP
rs1289551548 541 dbSNP
rs983466357 544 dbSNP
rs1344070031 546 dbSNP
rs1426925253 549 dbSNP
rs576281617 557 dbSNP
rs1437530954 562 dbSNP
rs907973773 565 dbSNP
rs1316442532 570 dbSNP
rs942116250 577 dbSNP
rs1389440681 578 dbSNP
rs1173019023 592 dbSNP
rs542083257 597 dbSNP
rs916087272 598 dbSNP
rs555583509 603 dbSNP
rs1384198355 608 dbSNP
rs749161450 610 dbSNP
rs1037762992 615 dbSNP
rs900692286 616 dbSNP
rs932100356 617 dbSNP
rs1214576412 618 dbSNP
rs766957625 622 dbSNP
rs1326577377 628 dbSNP
rs1403940263 630 dbSNP
rs1280995670 635 dbSNP
rs890706113 640 dbSNP
rs999638248 647 dbSNP
rs979045038 664 dbSNP
rs1220181969 668 dbSNP
rs371405158 669 dbSNP
rs1030647903 671 dbSNP
rs752069679 677 dbSNP
rs1366105019 679 dbSNP
rs572196337 680 dbSNP
rs1468242486 681 dbSNP
rs1405263576 683 dbSNP
rs541149311 685 dbSNP
rs1225769351 690 dbSNP
rs1415985833 693 dbSNP
rs1257051807 694 dbSNP
rs755561320 698 dbSNP
rs373550897 700 dbSNP
rs1203937729 701 dbSNP
rs1181232188 703 dbSNP
rs1010628600 706 dbSNP
rs1460429606 708 dbSNP
rs781559210 710 dbSNP
rs969200429 712 dbSNP
rs1198896677 729 dbSNP
rs1314347857 730 dbSNP
rs7248160 734 dbSNP
rs2111503 737 dbSNP
rs951309531 738 dbSNP
rs530531620 741 dbSNP
rs1049513064 744 dbSNP
rs983884595 748 dbSNP
rs543357714 752 dbSNP
rs1378472260 753 dbSNP
rs1303412935 759 dbSNP
rs963352115 760 dbSNP
rs1450094051 767 dbSNP
rs973489827 780 dbSNP
rs1352617930 786 dbSNP
rs868363919 801 dbSNP
rs1169471995 812 dbSNP
rs145350264 818 dbSNP
rs1391637511 819 dbSNP
rs1016834135 820 dbSNP
rs1443532397 821 dbSNP
rs777910691 824 dbSNP
rs1451543296 825 dbSNP
rs180733725 827 dbSNP
rs1484517026 828 dbSNP
rs749338773 830 dbSNP
rs550617288 831 dbSNP
rs1343262755 853 dbSNP
rs1300859379 861 dbSNP
rs1277058548 867 dbSNP
rs374828100 869 dbSNP
rs1321241443 881 dbSNP
rs912154299 896 dbSNP
rs935584369 897 dbSNP
rs1302378780 898 dbSNP
rs1371112018 900 dbSNP
rs28638285 911 dbSNP
rs774439252 912 dbSNP
rs990569102 913 dbSNP
rs1300948798 923 dbSNP
rs1457090343 924 dbSNP
rs893474609 931 dbSNP
rs745750687 941 dbSNP
rs1416722945 948 dbSNP
rs1406459788 951 dbSNP
rs1044826101 953 dbSNP
rs1483616593 955 dbSNP
rs1289796480 967 dbSNP
rs1220625953 971 dbSNP
rs1490894957 971 dbSNP
rs1488272988 975 dbSNP
rs970245411 976 dbSNP
rs570485519 988 dbSNP
rs1315162730 992 dbSNP
rs904947515 996 dbSNP
rs771907253 998 dbSNP
rs926204547 999 dbSNP
rs1228898066 1001 dbSNP
rs1352175615 1005 dbSNP
rs1281125304 1011 dbSNP
rs1210701080 1020 dbSNP
rs528630473 1021 dbSNP
rs934921715 1023 dbSNP
rs1003354167 1037 dbSNP
rs1034844952 1038 dbSNP
rs988795560 1061 dbSNP
rs1183822288 1076 dbSNP
rs1380880353 1077 dbSNP
rs1473204755 1078 dbSNP
rs775349628 1079 dbSNP
rs147657604 1089 dbSNP
rs1017225754 1090 dbSNP
rs1268360660 1091 dbSNP
rs760444699 1095 dbSNP
rs1484962670 1101 dbSNP
rs941221004 1111 dbSNP
rs1209340307 1113 dbSNP
rs763780366 1116 dbSNP
rs1297309286 1132 dbSNP
rs776459803 1136 dbSNP
rs1232296477 1138 dbSNP
rs1331418334 1146 dbSNP
rs897039282 1156 dbSNP
rs953425134 1159 dbSNP
rs185121279 1164 dbSNP
rs1320629709 1174 dbSNP
rs896176992 1178 dbSNP
rs912081187 1179 dbSNP
rs532935751 1182 dbSNP
rs1378553317 1186 dbSNP
rs967810709 1187 dbSNP
rs749964243 1190 dbSNP
rs1245947888 1191 dbSNP
rs1312970105 1195 dbSNP
rs1189298845 1201 dbSNP
rs1466275536 1208 dbSNP
rs1361758341 1209 dbSNP
rs1033603841 1210 dbSNP
rs1199781874 1214 dbSNP
rs1345497883 1217 dbSNP
rs139688822 1221 dbSNP
rs1052709128 1227 dbSNP
rs1257539898 1235 dbSNP
rs1224864227 1250 dbSNP
rs956278757 1253 dbSNP
rs915484133 1259 dbSNP
rs946422785 1262 dbSNP
rs773571184 1265 dbSNP
rs1379878768 1271 dbSNP
rs1245725294 1276 dbSNP
rs922619452 1296 dbSNP
rs1044691693 1297 dbSNP
rs1197361818 1302 dbSNP
rs955402017 1304 dbSNP
rs755508202 1322 dbSNP
rs1389814157 1325 dbSNP
rs904977289 1326 dbSNP
rs149864748 1327 dbSNP
rs767970583 1330 dbSNP
rs1366759620 1337 dbSNP
rs1186838172 1345 dbSNP
rs1460794199 1346 dbSNP
rs1442925127 1349 dbSNP
rs1258115132 1352 dbSNP
rs1181752327 1365 dbSNP
rs911283063 1376 dbSNP
rs56007660 1379 dbSNP
rs1004420973 1380 dbSNP
rs1016887373 1381 dbSNP
rs1038170739 1382 dbSNP
rs1244806120 1384 dbSNP
rs898413287 1385 dbSNP
rs1336671690 1388 dbSNP
rs1408405741 1397 dbSNP
rs1169226574 1405 dbSNP
rs1371014700 1406 dbSNP
rs1370311069 1407 dbSNP
rs190948489 1408 dbSNP
rs1431853324 1418 dbSNP
rs10500258 1419 dbSNP
rs778230800 1420 dbSNP
rs1011898637 1421 dbSNP
rs1472170676 1426 dbSNP
rs572284759 1433 dbSNP
rs1044767211 1445 dbSNP
rs1449527838 1449 dbSNP
rs1019412795 1451 dbSNP
rs1335336558 1456 dbSNP
rs1381348538 1464 dbSNP
rs956927435 1465 dbSNP
rs988711752 1468 dbSNP
rs1209944193 1476 dbSNP
rs903572089 1481 dbSNP
rs535268025 1493 dbSNP
rs1350322104 1494 dbSNP
rs757485503 1494 dbSNP
rs1289364864 1500 dbSNP
rs980958018 1504 dbSNP
rs926312242 1505 dbSNP
rs938977947 1506 dbSNP
rs1056225911 1508 dbSNP
rs778899825 1509 dbSNP
rs1010473847 1514 dbSNP
rs1392942711 1515 dbSNP
rs1156909152 1516 dbSNP
rs886852413 1528 dbSNP
rs895962375 1529 dbSNP
rs1038193662 1535 dbSNP
rs373841888 1537 dbSNP
rs1476895719 1542 dbSNP
rs955639256 1545 dbSNP
rs1220737923 1550 dbSNP
rs183275314 1564 dbSNP
rs557569791 1571 dbSNP
rs985398002 1572 dbSNP
rs1207451565 1574 dbSNP
rs1322622166 1586 dbSNP
rs1269249216 1590 dbSNP
rs577663804 1591 dbSNP
rs759919159 1598 dbSNP
rs1244897219 1599 dbSNP
rs1274536027 1600 dbSNP
rs148990206 1608 dbSNP
rs1437418924 1615 dbSNP
rs1302803439 1625 dbSNP
rs1456710012 1625 dbSNP
rs397752349 1625 dbSNP
rs61197606 1625 dbSNP
rs962727621 1631 dbSNP
rs974601477 1632 dbSNP
rs1483266951 1635 dbSNP
rs199713006 1636 dbSNP
rs1185449209 1639 dbSNP
rs1259111539 1643 dbSNP
rs1172866948 1648 dbSNP
rs368491238 1659 dbSNP
rs1245760078 1668 dbSNP
rs1028205002 1688 dbSNP
rs1464927183 1691 dbSNP
rs1249218544 1693 dbSNP
rs75643340 1702 dbSNP
rs201008639 1713 dbSNP
rs749027417 1713 dbSNP
rs992025617 1714 dbSNP
rs1278358561 1717 dbSNP
rs537162236 1717 dbSNP
rs889128110 1750 dbSNP
rs1044713231 1751 dbSNP
rs1467046677 1755 dbSNP
rs1009304406 1760 dbSNP
rs1290598471 1761 dbSNP
rs1445722275 1765 dbSNP
rs1360040164 1777 dbSNP
rs936427237 1779 dbSNP
rs73034207 1781 dbSNP
rs528855665 1782 dbSNP
rs1415894643 1783 dbSNP
rs956984981 1784 dbSNP
rs891943682 1785 dbSNP
rs1344561345 1788 dbSNP
rs1449599799 1794 dbSNP
rs1188872326 1796 dbSNP
rs1391449139 1796 dbSNP
rs542929860 1798 dbSNP
rs370114991 1819 dbSNP
rs1211299906 1823 dbSNP
rs1029843343 1831 dbSNP
rs1280587597 1831 dbSNP
rs1272812909 1832 dbSNP
rs36121535 1832 dbSNP
rs866754013 1839 dbSNP
rs1297793768 1840 dbSNP
rs980995347 1843 dbSNP
rs114968581 1860 dbSNP
rs939066159 1861 dbSNP
rs781062211 1871 dbSNP
rs1416418478 1878 dbSNP
rs962717565 1886 dbSNP
rs1489017243 1888 dbSNP
rs1429997158 1889 dbSNP
rs1371933721 1893 dbSNP
rs992233691 1895 dbSNP
rs1162109114 1897 dbSNP
rs1193851474 1898 dbSNP
rs1422687516 1903 dbSNP
rs1413731900 1906 dbSNP
rs1267779107 1907 dbSNP
rs1476414391 1917 dbSNP
rs974169640 1919 dbSNP
rs528666658 1925 dbSNP
rs200068586 1950 dbSNP
rs992369448 1953 dbSNP
rs917759934 1957 dbSNP
rs908311341 1960 dbSNP
rs1197690879 1963 dbSNP
rs1219508766 1973 dbSNP
rs939754675 1978 dbSNP
rs1235032376 1979 dbSNP
rs545774514 1979 dbSNP
rs898350990 1987 dbSNP
rs1159092275 1991 dbSNP
rs1287475584 1993 dbSNP
rs775337814 2000 dbSNP
rs1410143422 2010 dbSNP
rs1421594832 2019 dbSNP
rs1298986849 2031 dbSNP
rs375467451 2035 dbSNP
rs891033188 2039 dbSNP
rs924929630 2048 dbSNP
rs1349922842 2049 dbSNP
rs1166374449 2050 dbSNP
rs531017302 2056 dbSNP
rs779163240 2060 dbSNP
rs1463459729 2062 dbSNP
rs772019921 2066 dbSNP
rs1008922465 2079 dbSNP
rs1410319723 2086 dbSNP
rs1040762861 2089 dbSNP
rs866546303 2090 dbSNP
rs892437064 2091 dbSNP
rs1009622784 2092 dbSNP
rs1252959766 2097 dbSNP
rs1189675238 2118 dbSNP
rs1266105846 2124 dbSNP
rs1488223032 2124 dbSNP
rs1356584778 2141 dbSNP
rs936357557 2145 dbSNP
rs1052124671 2152 dbSNP
rs1403389613 2159 dbSNP
rs1022294838 2160 dbSNP
rs1228799861 2161 dbSNP
rs1337284988 2170 dbSNP
rs143746279 2181 dbSNP
rs968197213 2183 dbSNP
rs1327343121 2186 dbSNP
rs1432175545 2188 dbSNP
rs933092878 2192 dbSNP
rs567671160 2194 dbSNP
rs746788151 2209 dbSNP
rs1002321634 2210 dbSNP
rs1159016629 2211 dbSNP
rs1454680134 2214 dbSNP
rs1033933332 2215 dbSNP
rs1051164553 2227 dbSNP
rs1174309331 2230 dbSNP
rs1432806780 2233 dbSNP
rs200343528 2238 dbSNP
rs1223129179 2246 dbSNP
rs1304793529 2256 dbSNP
rs1195586584 2260 dbSNP
rs1355178923 2274 dbSNP
rs1247395550 2275 dbSNP
rs1216736970 2278 dbSNP
rs961230098 2283 dbSNP
rs1018506727 2284 dbSNP
rs146460149 2286 dbSNP
rs1025653568 2296 dbSNP
rs549307504 2299 dbSNP
rs1248806321 2303 dbSNP
rs1387672648 2310 dbSNP
rs1301478722 2317 dbSNP
rs1465800340 2318 dbSNP
rs1013709984 2322 dbSNP
rs1175732089 2323 dbSNP
rs1447774636 2324 dbSNP
rs1478569574 2328 dbSNP
rs1024807130 2329 dbSNP
rs565933781 2333 dbSNP
rs1441566789 2336 dbSNP
rs1253910441 2340 dbSNP
rs969239838 2341 dbSNP
rs973826408 2342 dbSNP
rs1282082495 2345 dbSNP
rs113559426 2357 dbSNP
rs1340929383 2358 dbSNP
rs1422968028 2359 dbSNP
rs932511002 2360 dbSNP
rs75418191 2364 dbSNP
rs1228903491 2375 dbSNP
rs557919955 2376 dbSNP
rs913568650 2386 dbSNP
rs1395833891 2391 dbSNP
rs1296332214 2394 dbSNP
rs933060001 2395 dbSNP
rs1428047433 2406 dbSNP
rs1378996145 2407 dbSNP
rs186487419 2414 dbSNP
rs1476409184 2424 dbSNP
rs1366666898 2426 dbSNP
rs1313735679 2430 dbSNP
rs372096797 2434 dbSNP
rs912715158 2436 dbSNP
rs1229622688 2438 dbSNP
rs1202658628 2439 dbSNP
rs1053016181 2440 dbSNP
rs1290158675 2441 dbSNP
rs1273191190 2446 dbSNP
rs942849859 2455 dbSNP
rs892463616 2456 dbSNP
rs1141656 2485 dbSNP
rs1264241361 2487 dbSNP
rs1244690556 2490 dbSNP
rs1452508323 2495 dbSNP
rs1009491735 2496 dbSNP
rs1408316270 2498 dbSNP
rs1039862653 2504 dbSNP
rs761495529 2509 dbSNP
rs1459455404 2534 dbSNP
rs1179889913 2540 dbSNP
rs191775092 2547 dbSNP
rs556747386 2550 dbSNP
rs1388634067 2551 dbSNP
rs1162661195 2553 dbSNP
rs1461883348 2568 dbSNP
rs769572193 2569 dbSNP
rs1471857889 2570 dbSNP
rs1165182476 2577 dbSNP
rs1047504152 2584 dbSNP
rs1414830882 2585 dbSNP
rs7256654 2594 dbSNP
rs762422674 2603 dbSNP
rs1402282198 2610 dbSNP
rs1447413413 2612 dbSNP
rs542173280 2646 dbSNP
rs1025088277 2649 dbSNP
rs1014273074 2659 dbSNP
rs1015808159 2662 dbSNP
rs1284372294 2664 dbSNP
rs865793302 2665 dbSNP
rs768041545 2674 dbSNP
rs542068483 2682 dbSNP
rs919697613 2683 dbSNP
rs1320517002 2686 dbSNP
rs953762708 2688 dbSNP
rs1322988259 2706 dbSNP
rs985176518 2707 dbSNP
rs913548567 2708 dbSNP
rs1199754619 2711 dbSNP
rs1156802469 2713 dbSNP
rs1205726752 2715 dbSNP
rs1243075076 2717 dbSNP
rs1440725852 2722 dbSNP
rs1159996592 2730 dbSNP
rs1476842767 2733 dbSNP
rs201439036 2737 dbSNP
rs369404619 2737 dbSNP
rs954429026 2737 dbSNP
rs912400170 2740 dbSNP
rs943845918 2743 dbSNP
rs1053450853 2744 dbSNP
rs1343143142 2745 dbSNP
rs913141693 2745 dbSNP
rs987117203 2745 dbSNP
rs371145688 2746 dbSNP
rs1373263133 2750 dbSNP
rs1318508542 2752 dbSNP
rs1043692630 2756 dbSNP
rs943132162 2757 dbSNP
rs1345652212 2761 dbSNP
rs1039811234 2762 dbSNP
rs1412499638 2763 dbSNP
rs1465953339 2765 dbSNP
rs1173851979 2783 dbSNP
rs903976091 2783 dbSNP
rs931550010 2784 dbSNP
rs938110696 2785 dbSNP
rs1055193755 2788 dbSNP
rs1403843272 2803 dbSNP
rs1187291731 2804 dbSNP
rs545304890 2805 dbSNP
rs1416149200 2814 dbSNP
rs1475382984 2816 dbSNP
rs896650093 2818 dbSNP
rs1243133997 2824 dbSNP
rs1218426183 2826 dbSNP
rs1441006067 2827 dbSNP
rs140856186 2830 dbSNP
rs1016298108 2838 dbSNP
rs761267350 2841 dbSNP
rs1213987188 2842 dbSNP
rs530981986 2844 dbSNP
rs561750364 2845 dbSNP
rs1026662486 2865 dbSNP
rs551067001 2867 dbSNP
rs985615382 2868 dbSNP
rs1436184917 2870 dbSNP
rs1019324988 2880 dbSNP
rs1167421544 2884 dbSNP
rs893672389 2887 dbSNP
rs1262966763 2894 dbSNP
rs965625187 2898 dbSNP
rs1343455900 2901 dbSNP
rs988661264 2904 dbSNP
rs1486777749 2905 dbSNP
rs35630677 2907 dbSNP
rs1279411606 2918 dbSNP
rs561183947 2922 dbSNP
rs1020893112 2926 dbSNP
rs1275077524 2933 dbSNP
rs1265657498 2948 dbSNP
rs954642364 2949 dbSNP
rs540545037 2952 dbSNP
rs1293694735 2955 dbSNP
rs987064844 2958 dbSNP
rs575369227 2960 dbSNP
rs1375756700 2961 dbSNP
rs1478963359 2963 dbSNP
rs772125649 2964 dbSNP
rs544003807 2966 dbSNP
rs978621179 2971 dbSNP
rs373195551 2972 dbSNP
rs1173147535 2981 dbSNP
rs1404108144 2983 dbSNP
rs566019618 2987 dbSNP
rs1166136384 2992 dbSNP
rs564154405 2999 dbSNP
rs534894016 3005 dbSNP
rs1249950543 3006 dbSNP
rs1481037484 3008 dbSNP
rs937974999 3008 dbSNP
rs375633709 3009 dbSNP
rs1055626670 3011 dbSNP
rs968431484 3012 dbSNP
rs773471224 3019 dbSNP
rs908764000 3021 dbSNP
rs949623531 3029 dbSNP
rs1283038822 3031 dbSNP
rs1329772039 3036 dbSNP
rs1305906903 3039 dbSNP
rs183090375 3055 dbSNP
rs779163906 3062 dbSNP
rs1291290417 3063 dbSNP
rs187787029 3073 dbSNP
rs1350000030 3079 dbSNP
rs536806337 3080 dbSNP
rs1238089231 3086 dbSNP
rs1166253384 3089 dbSNP
rs1288308143 3091 dbSNP
rs557024784 3098 dbSNP
rs144663851 3099 dbSNP
rs11880046 3102 dbSNP
rs893609978 3103 dbSNP
rs1253599552 3107 dbSNP
rs1027197953 3118 dbSNP
rs889461407 3120 dbSNP
rs138551989 3121 dbSNP
rs1453126570 3123 dbSNP
rs1259918745 3124 dbSNP
rs111237571 3133 dbSNP
rs12596 3137 dbSNP
rs573227049 3138 dbSNP
rs1437805708 3139 dbSNP
rs141138321 3142 dbSNP
rs965140456 3144 dbSNP
rs565402505 3147 dbSNP
rs575804301 3155 dbSNP
rs1327241613 3161 dbSNP
rs1383362917 3166 dbSNP
rs1443732391 3166 dbSNP
rs535460891 3166 dbSNP
rs964375506 3167 dbSNP
rs1347202262 3169 dbSNP
rs73565342 3170 dbSNP
rs1453914507 3172 dbSNP
rs968499107 3174 dbSNP
rs1195488242 3183 dbSNP
rs543852361 3188 dbSNP
rs1447600338 3191 dbSNP
rs1388945898 3199 dbSNP
rs927180155 3200 dbSNP
rs1027383962 3207 dbSNP
rs563744345 3212 dbSNP
rs1388922474 3214 dbSNP
rs950532128 3220 dbSNP
rs938051893 3222 dbSNP
rs990817084 3224 dbSNP
rs530208288 3230 dbSNP
rs918023758 3236 dbSNP
rs1376777300 3245 dbSNP
rs1238656070 3252 dbSNP
rs1348047533 3254 dbSNP
rs1305006604 3269 dbSNP
rs3746016 3271 dbSNP
rs1354569956 3295 dbSNP
rs1295433225 3297 dbSNP
rs374560265 3299 dbSNP
rs1263906655 3310 dbSNP
rs1037498790 3311 dbSNP
rs1364487108 3313 dbSNP
rs1311365394 3316 dbSNP
rs918758810 3318 dbSNP
rs1376236007 3325 dbSNP
rs1175633380 3326 dbSNP
rs746868945 3327 dbSNP
rs776810258 3328 dbSNP
rs1193768438 3331 dbSNP
rs768648945 3331 dbSNP
rs112134856 3341 dbSNP
rs760098387 3343 dbSNP
rs1006993115 3345 dbSNP
rs1249607185 3350 dbSNP
rs551663942 3351 dbSNP
rs1456385318 3353 dbSNP
rs1202436997 3354 dbSNP
rs150385161 3357 dbSNP
rs1251284429 3360 dbSNP
rs1228790955 3368 dbSNP
rs1328623008 3370 dbSNP
rs900807961 3371 dbSNP
rs747188823 3374 dbSNP
rs1238193476 3379 dbSNP
rs1443489077 3380 dbSNP
rs765592924 3383 dbSNP
rs1162217438 3394 dbSNP
rs1314973033 3400 dbSNP
rs1369863787 3405 dbSNP
rs1010006832 3412 dbSNP
rs1463473104 3413 dbSNP
rs945457251 3413 dbSNP
rs1415493785 3430 dbSNP
rs560141455 3431 dbSNP
rs1475385134 3437 dbSNP
rs1400107221 3446 dbSNP
rs890324969 3449 dbSNP
rs1008756032 3458 dbSNP
rs968531006 3463 dbSNP
rs1320636687 3464 dbSNP
rs1271764529 3465 dbSNP
rs1233105564 3468 dbSNP
rs748016334 3470 dbSNP
rs879098087 3486 dbSNP
rs1295417717 3498 dbSNP
rs1237135841 3508 dbSNP
rs1335335730 3521 dbSNP
rs900446336 3529 dbSNP
rs1034252346 3532 dbSNP
rs769551591 3550 dbSNP
rs528790354 3552 dbSNP
rs993125604 3555 dbSNP
rs1310783455 3562 dbSNP
rs116985108 3564 dbSNP
rs762701923 3566 dbSNP
rs1027741271 3569 dbSNP
rs568580951 3579 dbSNP
rs73565344 3580 dbSNP
rs1250538630 3582 dbSNP
rs1315853382 3584 dbSNP
rs1183401219 3588 dbSNP
rs1466730196 3593 dbSNP
rs1200391456 3610 dbSNP
rs1258669755 3615 dbSNP
rs931506696 3616 dbSNP
rs1179589877 3623 dbSNP
rs1292484009 3623 dbSNP
rs567059555 3625 dbSNP
rs970911326 3629 dbSNP
rs1048576784 3636 dbSNP
rs982340980 3637 dbSNP
rs535918519 3638 dbSNP
rs1241336956 3644 dbSNP
rs942981816 3648 dbSNP
rs1368837289 3649 dbSNP
rs1302668378 3650 dbSNP
rs1423284332 3650 dbSNP
rs112825888 3652 dbSNP
rs1315970271 3653 dbSNP
rs1464397128 3663 dbSNP
rs1173408125 3674 dbSNP
rs959902517 3696 dbSNP
rs1159902073 3707 dbSNP
rs1452099252 3709 dbSNP
rs989458286 3719 dbSNP
rs1193649168 3720 dbSNP
rs900839993 3721 dbSNP
rs1455087246 3723 dbSNP
rs1248922562 3736 dbSNP
rs533638906 3738 dbSNP
rs1466021641 3752 dbSNP
rs1285268520 3753 dbSNP
rs1301163623 3755 dbSNP
rs1219070141 3758 dbSNP
rs915269011 3762 dbSNP
rs945476217 3762 dbSNP
rs566144795 3778 dbSNP
rs1041482643 3781 dbSNP
rs773926443 3785 dbSNP
rs944520057 3787 dbSNP
rs1000013606 3801 dbSNP
rs1319941939 3803 dbSNP
rs1034159016 3807 dbSNP
rs1374398636 3811 dbSNP
rs1173750395 3826 dbSNP
rs1435987344 3836 dbSNP
rs538213283 3840 dbSNP
rs559205349 3841 dbSNP
rs116814670 3846 dbSNP
rs1243042994 3848 dbSNP
rs192531849 3883 dbSNP
rs886138901 3887 dbSNP
rs1279837172 3894 dbSNP
rs537626726 3899 dbSNP
rs970786004 3900 dbSNP
rs1024081829 3904 dbSNP
rs972724096 3905 dbSNP
rs918700064 3914 dbSNP
rs1213904473 3924 dbSNP
rs952761453 3943 dbSNP
rs1260630945 3944 dbSNP
rs1477018074 3950 dbSNP
rs138067481 3953 dbSNP
rs911415931 3957 dbSNP
rs376673528 3959 dbSNP
rs1003682910 3965 dbSNP
rs1033851839 3971 dbSNP
rs942823980 3977 dbSNP
rs1169032215 3984 dbSNP
rs1409912863 4003 dbSNP
rs1424835235 4007 dbSNP
rs1433101296 4009 dbSNP
rs959648980 4013 dbSNP
rs977039453 4015 dbSNP
rs915235516 4021 dbSNP
rs540590014 4022 dbSNP
rs1188912620 4023 dbSNP
rs1484308864 4029 dbSNP
rs1174591633 4035 dbSNP
rs922838117 4037 dbSNP
rs1360900616 4044 dbSNP
rs550692908 4046 dbSNP
rs1297773315 4049 dbSNP
rs376644562 4052 dbSNP
rs904168012 4053 dbSNP
rs1231279046 4055 dbSNP
rs754186193 4057 dbSNP
rs935770386 4063 dbSNP
rs1447447489 4068 dbSNP
rs1293601103 4075 dbSNP
rs978082007 4076 dbSNP
rs540747008 4077 dbSNP
rs1297111660 4084 dbSNP
rs1442254082 4106 dbSNP
rs1401695891 4111 dbSNP
rs1217343819 4112 dbSNP
rs570611272 4123 dbSNP
rs1460247237 4137 dbSNP
rs1417569479 4147 dbSNP
rs1312219056 4157 dbSNP
rs1166028644 4169 dbSNP
rs1425783979 4173 dbSNP
rs762213681 4173 dbSNP
rs1406011166 4179 dbSNP
rs571831985 4180 dbSNP
rs113025695 4181 dbSNP
rs10402286 4185 dbSNP
rs540112307 4186 dbSNP
rs545878080 4188 dbSNP
rs796845830 4189 dbSNP
rs565228103 4197 dbSNP
rs1364777477 4198 dbSNP
rs1024263534 4203 dbSNP
rs897717217 4215 dbSNP
rs1223906411 4219 dbSNP
rs1001325011 4220 dbSNP
rs1312165608 4227 dbSNP
rs1439354172 4231 dbSNP
rs994200466 4234 dbSNP
rs1033840491 4235 dbSNP
rs540867228 4238 dbSNP
rs118045755 4244 dbSNP
rs1427900232 4245 dbSNP
rs1434307198 4248 dbSNP
rs1229593109 4250 dbSNP
rs1343702963 4251 dbSNP
rs1011142480 4252 dbSNP
rs1025665973 4256 dbSNP
rs1440468631 4261 dbSNP
rs1382233828 4268 dbSNP
rs952669080 4269 dbSNP
rs550386798 4277 dbSNP
rs984209604 4292 dbSNP
rs1022947664 4293 dbSNP
rs1453731117 4298 dbSNP
rs1253506839 4300 dbSNP
rs765413703 4317 dbSNP
rs1378622594 4318 dbSNP
rs1018741358 4319 dbSNP
rs1216065467 4323 dbSNP
rs964278673 4324 dbSNP
rs1277574368 4340 dbSNP
rs1232872238 4351 dbSNP
rs1370934797 4352 dbSNP
rs1302559602 4354 dbSNP
rs1388927146 4357 dbSNP
rs977323596 4373 dbSNP
rs1349018093 4389 dbSNP
rs922906192 4392 dbSNP
rs1420553405 4394 dbSNP
rs1362621612 4406 dbSNP
rs567144871 4411 dbSNP
rs750571532 4412 dbSNP
rs1434135860 4420 dbSNP
rs1378184920 4424 dbSNP
rs529804067 4428 dbSNP
rs1295167708 4432 dbSNP
rs1200882033 4437 dbSNP
rs1368188162 4442 dbSNP
rs1264372023 4447 dbSNP
rs966094998 4463 dbSNP
rs974830960 4464 dbSNP
rs1186834021 4466 dbSNP
rs1489081794 4468 dbSNP
rs925623940 4478 dbSNP
rs1209582301 4479 dbSNP
rs930496237 4494 dbSNP
rs984659186 4498 dbSNP
rs1306448930 4502 dbSNP
rs1236065447 4521 dbSNP
rs1306198304 4522 dbSNP
rs1295324229 4535 dbSNP
rs1400940329 4538 dbSNP
rs546296370 4546 dbSNP
rs940595653 4551 dbSNP
rs1414293843 4556 dbSNP
rs1240339946 4558 dbSNP
rs1288741656 4566 dbSNP
rs1045423749 4571 dbSNP
rs1055580144 4584 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions TZM-bl
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM1462574. RNA binding protein: AGO2. Condition:TZM-bl ami BaL ...

- Whisnant AW; Bogerd HP; Flores O; Ho P; et al., 2013, mBio.

Article - Whisnant AW; Bogerd HP; Flores O; Ho P; et al.
- mBio, 2013
UNLABELLED: The question of how HIV-1 interfaces with cellular microRNA (miRNA) biogenesis and effector mechanisms has been highly controversial. Here, we first used deep sequencing of small RNAs present in two different infected cell lines (TZM-bl and C8166) and two types of primary human cells (CD4(+) peripheral blood mononuclear cells [PBMCs] and macrophages) to unequivocally demonstrate that HIV-1 does not encode any viral miRNAs. Perhaps surprisingly, we also observed that infection of T cells by HIV-1 has only a modest effect on the expression of cellular miRNAs at early times after infection. Comprehensive analysis of miRNA binding to the HIV-1 genome using the photoactivatable ribonucleoside-induced cross-linking and immunoprecipitation (PAR-CLIP) technique revealed several binding sites for cellular miRNAs, a subset of which were shown to be capable of mediating miRNA-mediated repression of gene expression. However, the main finding from this analysis is that HIV-1 transcripts are largely refractory to miRNA binding, most probably due to extensive viral RNA secondary structure. Together, these data demonstrate that HIV-1 neither encodes viral miRNAs nor strongly influences cellular miRNA expression, at least early after infection, and imply that HIV-1 transcripts have evolved to avoid inhibition by preexisting cellular miRNAs by adopting extensive RNA secondary structures that occlude most potential miRNA binding sites. IMPORTANCE: MicroRNAs (miRNAs) are a ubiquitous class of small regulatory RNAs that serve as posttranscriptional regulators of gene expression. Previous work has suggested that HIV-1 might subvert the function of the cellular miRNA machinery by expressing viral miRNAs or by dramatically altering the level of cellular miRNA expression. Using very sensitive approaches, we now demonstrate that neither of these ideas is in fact correct. Moreover, HIV-1 transcripts appear to largely avoid regulation by cellular miRNAs by adopting an extensive RNA secondary structure that occludes the ability of cellular miRNAs to interact with viral mRNAs. Together, these data suggest that HIV-1, rather than seeking to control miRNA function in infected cells, has instead evolved a mechanism to become largely invisible to cellular miRNA effector mechanisms.
LinkOut: [PMID: 23592263]
CLIP-seq Support 1 for dataset GSM1462574
Method / RBP PAR-CLIP / AGO2
Cell line / Condition TZM-bl / TZM-bl ami BaL
Location of target site ENST00000311921.4 | 3UTR | AUUUAUAUAUACUAUAUUCCUCAAAUCCACUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23592263 / GSE59944
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
KIRP 0.496 0.02 0.485 0.02 17 Click to see details
BLCA 0.398 0.11 -0.064 0.43 11 Click to see details
BRCA -0.173 0.13 -0.262 0.04 46 Click to see details
UCEC -0.408 0.14 -0.167 0.33 9 Click to see details
LIHC 0.172 0.23 0.171 0.24 20 Click to see details
CHOL -0.673 0.27 -0.500 0.33 3 Click to see details
PRAD -0.134 0.38 -0.095 0.41 8 Click to see details
THCA 0.03 0.42 0.109 0.23 48 Click to see details
LUAD -0.077 0.42 -0.033 0.47 9 Click to see details
HNSC -0.052 0.42 -0.215 0.21 16 Click to see details
KIRC 0.024 0.45 -0.049 0.4 27 Click to see details
PAAD -0.06 0.48 -0.500 0.33 3 Click to see details
LUSC 0.006 0.49 -0.125 0.28 23 Click to see details
STAD 0.005 0.49 0.055 0.41 18 Click to see details
KICH 0.003 0.5 -0.096 0.37 15 Click to see details
KICH 0.003 0.5 -0.096 0.37 15 Click to see details
KICH 0.003 0.5 -0.096 0.37 15 Click to see details
KICH 0.003 0.5 -0.096 0.37 15 Click to see details
KICH 0.003 0.5 -0.096 0.37 15 Click to see details
KICH 0.003 0.5 -0.096 0.37 15 Click to see details
107 hsa-miR-605-5p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT001230 SEC24D SEC24 homolog D, COPII coat complex component 3 1
MIRT016155 TP53 tumor protein p53 2 1
MIRT016156 TCEAL1 transcription elongation factor A like 1 1 1
MIRT016157 MDM2 MDM2 proto-oncogene 2 1
MIRT040476 YBX1 Y-box binding protein 1 1 1
MIRT040477 TMEM64 transmembrane protein 64 1 1
MIRT040478 KDM5C lysine demethylase 5C 1 1
MIRT040479 TRAF4 TNF receptor associated factor 4 1 1
MIRT040480 DRG1 developmentally regulated GTP binding protein 1 1 1
MIRT040481 BCL9 B-cell CLL/lymphoma 9 1 1
MIRT055125 SCD stearoyl-CoA desaturase 2 2
MIRT057521 CEP55 centrosomal protein 55 2 2
MIRT081129 LDLR low density lipoprotein receptor 2 6
MIRT096817 ZSWIM6 zinc finger SWIM-type containing 6 2 4
MIRT100961 CENPQ centromere protein Q 2 4
MIRT263338 ANAPC16 anaphase promoting complex subunit 16 2 2
MIRT274710 CPSF6 cleavage and polyadenylation specific factor 6 2 2
MIRT311193 ANKRD33B ankyrin repeat domain 33B 2 2
MIRT360127 DEK DEK proto-oncogene 2 2
MIRT438269 PSMD10 proteasome 26S subunit, non-ATPase 10 2 1
MIRT442464 SLC25A13 solute carrier family 25 member 13 2 2
MIRT446110 TSC22D2 TSC22 domain family member 2 2 2
MIRT463119 ZNF507 zinc finger protein 507 2 2
MIRT470566 POU2F1 POU class 2 homeobox 1 2 2
MIRT475059 IVNS1ABP influenza virus NS1A binding protein 2 6
MIRT482538 ACTB actin beta 2 4
MIRT494136 DCAF7 DDB1 and CUL4 associated factor 7 2 6
MIRT495209 EDN3 endothelin 3 2 2
MIRT495235 LONRF3 LON peptidase N-terminal domain and ring finger 3 2 2
MIRT496762 MANBAL mannosidase beta like 2 2
MIRT498885 ZNF12 zinc finger protein 12 2 10
MIRT499280 NBPF11 NBPF member 11 2 2
MIRT507063 H3F3B H3 histone family member 3B 2 2
MIRT508352 HES7 hes family bHLH transcription factor 7 2 8
MIRT510740 SMC1A structural maintenance of chromosomes 1A 2 6
MIRT519872 ZFP62 ZFP62 zinc finger protein 2 4
MIRT521272 RTN4 reticulon 4 2 4
MIRT522324 NFIB nuclear factor I B 2 6
MIRT525011 ACTN4 actinin alpha 4 2 6
MIRT526608 AASDH aminoadipate-semialdehyde dehydrogenase 2 4
MIRT529043 ARL9 ADP ribosylation factor like GTPase 9 2 2
MIRT529545 ZNF678 zinc finger protein 678 2 2
MIRT532500 HOXA13 homeobox A13 2 2
MIRT532599 SIX4 SIX homeobox 4 2 2
MIRT534044 STK4 serine/threonine kinase 4 2 2
MIRT534087 SPPL3 signal peptide peptidase like 3 2 2
MIRT534249 SLC16A1 solute carrier family 16 member 1 2 2
MIRT534286 SLC12A7 solute carrier family 12 member 7 2 2
MIRT534555 RUNX1 runt related transcription factor 1 2 2
MIRT536765 HOXB2 homeobox B2 2 2
MIRT537227 GAN gigaxonin 2 2
MIRT551105 TTC8 tetratricopeptide repeat domain 8 2 2
MIRT552247 DUSP3 dual specificity phosphatase 3 2 2
MIRT554361 SFXN5 sideroflexin 5 2 2
MIRT557402 H3F3C H3 histone family member 3C 2 2
MIRT559116 C16orf52 chromosome 16 open reading frame 52 2 2
MIRT560494 BUB3 BUB3, mitotic checkpoint protein 2 2
MIRT562296 GLO1 glyoxalase I 2 2
MIRT562597 CAPZA2 capping actin protein of muscle Z-line alpha subunit 2 2 2
MIRT563857 ALYREF Aly/REF export factor 2 4
MIRT565665 SIX1 SIX homeobox 1 2 2
MIRT568253 BTF3L4 basic transcription factor 3 like 4 2 2
MIRT609593 GPM6B glycoprotein M6B 2 2
MIRT611552 GGT6 gamma-glutamyltransferase 6 2 2
MIRT613451 CYLD CYLD lysine 63 deubiquitinase 2 2
MIRT615516 PRRC2A proline rich coiled-coil 2A 2 2
MIRT617766 C17orf105 chromosome 17 open reading frame 105 2 2
MIRT619134 MCOLN3 mucolipin 3 2 2
MIRT621365 CAP2 cyclase associated actin cytoskeleton regulatory protein 2 2 2
MIRT625804 MDC1 mediator of DNA damage checkpoint 1 2 2
MIRT626954 PRDM2 PR/SET domain 2 2 2
MIRT627716 RCAN1 regulator of calcineurin 1 2 2
MIRT628069 KCNJ13 potassium voltage-gated channel subfamily J member 13 2 2
MIRT630451 GTPBP8 GTP binding protein 8 (putative) 2 2
MIRT635533 ELMOD2 ELMO domain containing 2 2 2
MIRT636206 SULF2 sulfatase 2 2 2
MIRT638763 EPHA4 EPH receptor A4 2 2
MIRT640324 STAT1 signal transducer and activator of transcription 1 2 2
MIRT644548 SPOP speckle type BTB/POZ protein 2 2
MIRT645114 TMX2 thioredoxin related transmembrane protein 2 2 2
MIRT647778 NANOS1 nanos C2HC-type zinc finger 1 2 2
MIRT650112 ZCCHC9 zinc finger CCHC-type containing 9 2 2
MIRT650136 ABCB7 ATP binding cassette subfamily B member 7 2 2
MIRT650310 SLC35E2 solute carrier family 35 member E2 2 2
MIRT650930 ST6GALNAC1 ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 2 2
MIRT651018 ZNF740 zinc finger protein 740 2 2
MIRT653541 SLC38A9 solute carrier family 38 member 9 2 2
MIRT655752 NR2C2 nuclear receptor subfamily 2 group C member 2 2 2
MIRT656908 KIAA1958 KIAA1958 2 2
MIRT657854 GJD3 gap junction protein delta 3 2 2
MIRT658215 FBXO21 F-box protein 21 2 2
MIRT659884 CAPN7 calpain 7 2 2
MIRT659922 CACNA1E calcium voltage-gated channel subunit alpha1 E 2 2
MIRT660055 C12orf5 TP53 induced glycolysis regulatory phosphatase 1 1
MIRT664616 LIMD1 LIM domains containing 1 2 2
MIRT665392 WEE1 WEE1 G2 checkpoint kinase 2 2
MIRT667887 IP6K1 inositol hexakisphosphate kinase 1 2 2
MIRT669018 CHORDC1 cysteine and histidine rich domain containing 1 2 2
MIRT688419 DUSP2 dual specificity phosphatase 2 2 2
MIRT691888 GXYLT2 glucoside xylosyltransferase 2 2 2
MIRT709530 GEN1 GEN1, Holliday junction 5' flap endonuclease 2 2
MIRT711013 ABCD2 ATP binding cassette subfamily D member 2 2 2
MIRT714731 CENPH centromere protein H 2 2
MIRT719897 PTGIS prostaglandin I2 synthase 2 2
MIRT725028 CX3CL1 C-X3-C motif chemokine ligand 1 2 2
MIRT734348 P2RY12 purinergic receptor P2Y12 3 0
MIRT736719 TNFAIP3 TNF alpha induced protein 3 3 0
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-605 Anthranilamide-pyrazolo[1,5-a]pyrimidine NULL NULL Quantitative real-time PCR neuroblastoma cells 23992861 2013 up-regualted
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-605 Ceritinib 57379345 NSC776422 approved resistant High Non-Small Cell Lung Cancer cell line (H3122, H2228)
hsa-mir-605 Paclitaxel 36314 NSC125973 approved sensitive cell line (A2780)
hsa-mir-605 Cisplatin 5460033 NSC119875 approved sensitive cell line (A2780)
hsa-mir-605 Ceritinib 57379345 NSC776422 approved resistant cell line (H3122)
hsa-miR-605-5p Verapamil 2520 NSC272366 approved resistant High Breast Cancer cell line (MCF-7)
hsa-miR-605-5p Doxorubicin 31703 NSC123127 approved resistant High Breast Cancer cell line (MCF-7)
hsa-miR-605-5p Navitoclax 24978538 NSC759659 sensitive High Colorectal Cancer cell line (HCT-116, CHL1)
hsa-miR-605-5p Gemcitabine 60750 NSC613327 approved sensitive Low Pancreatic Cancer cell line (BxPC‐3, PANC‐1)
hsa-miR-605-5p Paclitaxel 36314 NSC125973 approved sensitive High Non-Small Cell Lung Cancer cell line (H358, H1155)
hsa-miR-605-5p Cisplatin 5460033 NSC119875 approved sensitive High Gastric Cancer tissue
hsa-miR-605-5p Fluorouracil 3385 NSC19893 approved sensitive High Gastric Cancer tissue
hsa-miR-605-5p Fluorouracil 3385 NSC19893 approved resistant Low Colon Cancer cell line (HT-29, LoVo)
hsa-miR-605-5p Everolimus + Panobinostat sensitive Low Clear Cell Renal Cell Carcinoma tissue
hsa-miR-605-5p Gefitinib 123631 NSC715055 approved resistant cell line (PC9)
hsa-miR-605-5p Gefitinib 123631 NSC715055 approved resistant cell line (HCC827)
hsa-miR-605-5p Osimertinib 71496458 NSC779217 approved resistant cell line (PC9)
hsa-miR-605-5p Vemurafenib 42611257 NSC761431 approved resistant cell line (451Lu)
hsa-miR-605-5p Gefitinib 123631 NSC715055 approved sensitive cell line (HCC827)
hsa-miR-605-5p Cisplatin 5460033 NSC119875 approved sensitive cell line (A2780)
hsa-miR-605-5p 4-Hydroxytamoxifen+Tamoxifen sensitive cell line (LY2)
hsa-miR-605-5p Sunitinib 5329102 NSC750690 approved resistant tissue (CardB)
hsa-miR-605-5p Paclitaxel 36314 NSC125973 approved sensitive cell line (SKOV3)
hsa-miR-605-5p Pegylated interferon alpha+Ribavirin sensitive tissue (chronic hepatitis C)
hsa-miR-605-5p Cisplatin 5460033 NSC119875 approved sensitive cell line (IGROV-1)
hsa-miR-605-5p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-605-5p Gemcitabine 60750 NSC613327 approved sensitive cell line (PANC-1) (100 ng/ml)
hsa-miR-605-5p Gemcitabine 60750 NSC613327 approved sensitive cell line (PANC-1) (1500 ng/ml)
hsa-miR-605-5p Cisplatin 5460033 NSC119875 approved sensitive cell line (OVCAR3)
hsa-miR-605-5p Cisplatin 5460033 NSC119875 approved resistant cell line (H460)
hsa-miR-605-5p Paclitaxel/Docetaxel/Vinorelbine/Doxorubicin/Etoposide resistant cell line (Bads-200)

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